Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	159.0	14023.0	88.0	-0.685	0.075	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by the Hedgehog family	109.0	5683.0	52.0	-0.412	0.214	1000.0	-1000.0	-0.048	-1000.0
Endothelins	92.0	8871.0	96.0	-0.371	0.102	1000.0	-1000.0	-0.057	-1000.0
Aurora B signaling	75.0	5055.0	67.0	-0.3	0.28	1000.0	-1000.0	-0.035	-1000.0
Fc-epsilon receptor I signaling in mast cells	66.0	6459.0	97.0	-0.14	0.023	1000.0	-1000.0	-0.064	-1000.0
Thromboxane A2 receptor signaling	62.0	6589.0	105.0	-0.206	0.057	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	58.0	5307.0	91.0	-0.807	0.499	1000.0	-1000.0	-0.138	-1000.0
Signaling mediated by p38-alpha and p38-beta	57.0	2544.0	44.0	-0.103	0.022	1000.0	-1000.0	-0.025	-1000.0
amb2 Integrin signaling	56.0	4665.0	82.0	-0.477	0.036	1000.0	-1000.0	-0.039	-1000.0
TCGA08_retinoblastoma	56.0	453.0	8.0	-0.009	0.092	1000.0	-1000.0	-0.004	-1000.0
Aurora C signaling	53.0	376.0	7.0	-0.004	0.148	1000.0	-1000.0	-0.015	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	53.0	2783.0	52.0	-0.25	0.047	1000.0	-1000.0	-0.042	-1000.0
Signaling events regulated by Ret tyrosine kinase	48.0	3944.0	82.0	-0.107	0.054	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	40.0	3151.0	78.0	-0.158	0.051	1000.0	-1000.0	-0.044	-1000.0
BMP receptor signaling	38.0	3089.0	81.0	-0.262	0.146	1000.0	-1000.0	-0.04	-1000.0
Nongenotropic Androgen signaling	37.0	1969.0	52.0	-0.115	0.076	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	36.0	1120.0	31.0	-0.161	0.024	1000.0	-1000.0	-0.051	-1000.0
Arf6 signaling events	35.0	2189.0	62.0	-0.131	0.043	1000.0	-1000.0	-0.035	-1000.0
Integrins in angiogenesis	35.0	2967.0	84.0	-0.314	0.121	1000.0	-1000.0	-0.047	-1000.0
PLK1 signaling events	34.0	2905.0	85.0	-0.026	0.157	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	31.0	1581.0	51.0	-0.322	0.151	1000.0	-1000.0	-0.059	-1000.0
Coregulation of Androgen receptor activity	28.0	2179.0	76.0	-0.32	0.091	1000.0	-1000.0	-0.027	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	28.0	2430.0	85.0	-0.107	0.031	1000.0	-1000.0	-0.044	-1000.0
Presenilin action in Notch and Wnt signaling	28.0	1733.0	61.0	-0.322	0.151	1000.0	-1000.0	-0.047	-1000.0
Reelin signaling pathway	28.0	1582.0	56.0	-0.065	0.059	1000.0	-1000.0	-0.042	-1000.0
IL6-mediated signaling events	28.0	2170.0	75.0	-0.461	0.048	1000.0	-1000.0	-0.059	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	28.0	1961.0	68.0	-0.173	0.039	1000.0	-1000.0	-0.088	-1000.0
TCR signaling in naïve CD8+ T cells	26.0	2465.0	93.0	-0.061	0.032	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	26.0	106.0	4.0	0.027	0.056	1000.0	-1000.0	0.009	-1000.0
IL23-mediated signaling events	26.0	1574.0	60.0	-0.195	0.025	1000.0	-1000.0	-0.103	-1000.0
Visual signal transduction: Cones	25.0	985.0	38.0	-0.036	0.125	1000.0	-1000.0	-0.027	-1000.0
Syndecan-3-mediated signaling events	25.0	906.0	35.0	-0.235	0.055	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	24.0	297.0	12.0	-0.093	0.0	1000.0	-1000.0	-0.024	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	24.0	794.0	33.0	-0.159	0.091	1000.0	-1000.0	-0.032	-1000.0
IL12-mediated signaling events	23.0	2017.0	87.0	-0.163	0.044	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	23.0	2905.0	125.0	-0.12	0.05	1000.0	-1000.0	-0.055	-1000.0
Plasma membrane estrogen receptor signaling	23.0	2036.0	86.0	-0.109	0.037	1000.0	-1000.0	-0.054	-1000.0
Regulation of Androgen receptor activity	23.0	1621.0	70.0	-0.35	0.14	1000.0	-1000.0	-0.048	-1000.0
Syndecan-1-mediated signaling events	22.0	768.0	34.0	-0.09	0.148	1000.0	-1000.0	-0.043	-1000.0
HIF-1-alpha transcription factor network	22.0	1743.0	76.0	-0.118	0.116	1000.0	-1000.0	-0.125	-1000.0
Glucocorticoid receptor regulatory network	22.0	2572.0	114.0	-0.33	0.063	1000.0	-1000.0	-0.055	-1000.0
Nectin adhesion pathway	21.0	1331.0	63.0	-0.031	0.12	1000.0	-1000.0	-0.043	-1000.0
Wnt signaling	21.0	149.0	7.0	0.007	0.054	1000.0	-1000.0	-0.019	-1000.0
Glypican 1 network	20.0	977.0	48.0	-0.135	0.082	1000.0	-1000.0	-0.032	-1000.0
FOXM1 transcription factor network	20.0	1034.0	51.0	0.022	0.309	1000.0	-1000.0	-0.132	-1000.0
ErbB4 signaling events	19.0	1333.0	69.0	-0.127	0.161	1000.0	-1000.0	-0.047	-1000.0
IGF1 pathway	19.0	1089.0	57.0	-0.053	0.056	1000.0	-1000.0	-0.045	-1000.0
Caspase cascade in apoptosis	18.0	1335.0	74.0	-0.063	0.082	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	18.0	656.0	36.0	-0.104	0.022	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	18.0	866.0	47.0	-0.193	0.059	1000.0	-1000.0	-0.042	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	18.0	2201.0	120.0	-0.135	0.06	1000.0	-1000.0	-0.051	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	17.0	944.0	54.0	-0.065	0.072	1000.0	-1000.0	-0.057	-1000.0
JNK signaling in the CD4+ TCR pathway	17.0	296.0	17.0	-0.037	0.032	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	17.0	123.0	7.0	-0.032	0.022	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Rods	16.0	834.0	52.0	-0.036	0.092	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	15.0	1908.0	125.0	-0.046	0.143	1000.0	-1000.0	-0.075	-1000.0
PDGFR-alpha signaling pathway	15.0	669.0	44.0	-0.12	0.044	1000.0	-1000.0	-0.041	-1000.0
Ephrin B reverse signaling	14.0	715.0	48.0	-0.057	0.062	1000.0	-1000.0	-0.028	-1000.0
BCR signaling pathway	14.0	1482.0	99.0	-0.093	0.052	1000.0	-1000.0	-0.05	-1000.0
Osteopontin-mediated events	13.0	496.0	38.0	-0.048	0.124	1000.0	-1000.0	-0.054	-1000.0
Noncanonical Wnt signaling pathway	13.0	353.0	26.0	-0.051	0.054	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	13.0	1047.0	76.0	-0.044	0.058	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	13.0	782.0	60.0	-0.037	0.201	1000.0	-1000.0	-0.035	-1000.0
Effects of Botulinum toxin	13.0	341.0	26.0	-0.031	0.029	1000.0	-1000.0	-0.015	-1000.0
EGFR-dependent Endothelin signaling events	13.0	276.0	21.0	-0.025	0.049	1000.0	-1000.0	-0.041	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	12.0	909.0	74.0	-0.136	0.048	1000.0	-1000.0	-0.064	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	219.0	17.0	-0.02	0.03	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	314.0	28.0	-0.109	0.043	1000.0	-1000.0	-0.027	-1000.0
Hedgehog signaling events mediated by Gli proteins	11.0	736.0	65.0	-0.512	0.055	1000.0	-1000.0	-0.052	-1000.0
HIF-2-alpha transcription factor network	11.0	497.0	43.0	-0.07	0.064	1000.0	-1000.0	-0.074	-1000.0
Syndecan-2-mediated signaling events	10.0	708.0	69.0	-0.028	0.082	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	10.0	719.0	67.0	-0.032	0.082	1000.0	-1000.0	-0.044	-1000.0
S1P4 pathway	10.0	257.0	25.0	-0.026	0.032	1000.0	-1000.0	-0.029	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1265.0	136.0	-0.216	0.144	1000.0	-1000.0	-0.052	-1000.0
Cellular roles of Anthrax toxin	9.0	365.0	39.0	-0.059	0.023	1000.0	-1000.0	-0.022	-1000.0
ErbB2/ErbB3 signaling events	8.0	584.0	65.0	-0.036	0.033	1000.0	-1000.0	-0.053	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	382.0	46.0	-0.227	0.045	1000.0	-1000.0	-0.092	-1000.0
mTOR signaling pathway	8.0	474.0	53.0	-0.017	0.092	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	8.0	517.0	58.0	-0.151	0.045	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	8.0	749.0	85.0	-0.043	0.07	1000.0	-1000.0	-0.065	-1000.0
LPA receptor mediated events	8.0	911.0	102.0	-0.06	0.041	1000.0	-1000.0	-0.072	-1000.0
IL2 signaling events mediated by STAT5	8.0	184.0	22.0	0.004	0.074	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	8.0	344.0	43.0	-0.049	0.063	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	7.0	461.0	58.0	-0.019	0.116	1000.0	-1000.0	-0.045	-1000.0
Regulation of p38-alpha and p38-beta	7.0	414.0	54.0	-0.035	0.052	1000.0	-1000.0	-0.05	-1000.0
IL27-mediated signaling events	7.0	386.0	51.0	-0.062	0.029	1000.0	-1000.0	-0.054	-1000.0
TCGA08_rtk_signaling	7.0	195.0	26.0	-0.063	0.081	1000.0	-1000.0	-0.012	-1000.0
Insulin Pathway	7.0	561.0	74.0	-0.082	0.059	1000.0	-1000.0	-0.059	-1000.0
PDGFR-beta signaling pathway	7.0	712.0	97.0	-0.045	0.064	1000.0	-1000.0	-0.06	-1000.0
Ephrin A  reverse signaling	6.0	43.0	7.0	-0.011	0.029	1000.0	-1000.0	-0.023	-1000.0
IFN-gamma pathway	6.0	469.0	68.0	-0.03	0.064	1000.0	-1000.0	-0.055	-1000.0
Ceramide signaling pathway	6.0	474.0	76.0	-0.011	0.059	1000.0	-1000.0	-0.038	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	563.0	83.0	-0.063	0.041	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	298.0	45.0	-0.018	0.051	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events	6.0	494.0	73.0	-0.029	0.042	1000.0	-1000.0	-0.041	-1000.0
S1P3 pathway	6.0	291.0	42.0	-0.109	0.042	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PRL	6.0	231.0	34.0	-0.034	0.064	1000.0	-1000.0	-0.048	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	192.0	34.0	-0.031	0.05	1000.0	-1000.0	-0.034	-1000.0
EPO signaling pathway	5.0	306.0	55.0	-0.01	0.06	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class III	5.0	202.0	40.0	-0.076	0.041	1000.0	-1000.0	-0.029	-1000.0
IL1-mediated signaling events	5.0	311.0	62.0	-0.019	0.041	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	5.0	265.0	49.0	-0.0	0.033	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class II	4.0	326.0	75.0	-0.034	0.054	1000.0	-1000.0	-0.036	-1000.0
BARD1 signaling events	4.0	257.0	57.0	-0.041	0.089	1000.0	-1000.0	-0.045	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	20.0	5.0	0.016	0.027	1000.0	-1000.0	0.008	-1000.0
TRAIL signaling pathway	4.0	206.0	48.0	-0.034	0.06	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class I	4.0	507.0	104.0	-0.042	0.055	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	330.0	76.0	-0.012	0.059	1000.0	-1000.0	-0.059	-1000.0
VEGFR1 specific signals	4.0	276.0	56.0	-0.12	0.054	1000.0	-1000.0	-0.054	-1000.0
Insulin-mediated glucose transport	3.0	103.0	32.0	-0.009	0.042	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	229.0	68.0	-0.033	0.047	1000.0	-1000.0	-0.034	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	139.0	37.0	-0.013	0.05	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	3.0	250.0	64.0	-0.021	0.07	1000.0	-1000.0	-0.068	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	114.0	36.0	-0.04	0.042	1000.0	-1000.0	-0.045	-1000.0
Regulation of Telomerase	3.0	377.0	102.0	-0.042	0.065	1000.0	-1000.0	-0.063	-1000.0
p38 MAPK signaling pathway	3.0	146.0	44.0	-0.002	0.054	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	2.0	97.0	39.0	-0.006	0.046	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	2.0	203.0	71.0	-0.049	0.04	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.019	0.019	1000.0	-1000.0	-0.008	-1000.0
Circadian rhythm pathway	1.0	31.0	22.0	-0.006	0.047	1000.0	-1000.0	-0.033	-1000.0
Arf6 downstream pathway	1.0	68.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	1.0	24.0	17.0	-0.015	0.03	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.04	-1000.0
Rapid glucocorticoid signaling	1.0	27.0	20.0	-0.01	0.024	1000.0	-1000.0	-0.014	-1000.0
Arf1 pathway	1.0	67.0	54.0	-0.005	0.03	1000.0	-1000.0	-0.015	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	16.0	23.0	0.003	0.042	1000.0	-1000.0	-0.022	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	-0.01	0.022	1000.0	-1000.0	-0.027	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.008	0.023	1000.0	-1000.0	-0.032	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.01	0.053	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.021	0.041	1000.0	-1000.0	0.007	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.06	1000.0	-1000.0	-0.0	-1000.0
Total	2472	160682	7203	-13.5052873821	9.25171486461	131000	-131000	-5.64747835538	-131000