Clinical Features CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q 1p gain 10 (11%) 77 0.01428 0.195 0.78203 0.937 0.76849 0.937 0.68337 0.906 0.44042 0.804 0.8193 0.955 0.23348 0.643 0.3418 0.742 1q gain 21 (24%) 66 0.0094099 0.154 0.03169 0.303 0.10377 0.484 0.15705 0.544 0.2315 0.64 0.20606 0.606 0.57443 0.879 0.50952 0.846 2p gain 4 (5%) 83 0.10348 0.484 0.37421 0.76 0.60725 0.896 0.78494 0.937 0.12188 0.506 0.14263 0.524 0.35673 0.747 0.18186 0.576 2q gain 7 (8%) 80 0.5163 0.847 0.45996 0.814 0.355 0.747 0.42501 0.789 0.24696 0.665 0.91256 0.978 0.13322 0.52 0.063799 0.445 3p gain 17 (20%) 70 0.00063999 0.0253 0.93044 0.984 0.61939 0.905 0.6238 0.906 0.88873 0.973 0.88414 0.973 0.44066 0.804 0.60573 0.896 3q gain 19 (22%) 68 0.00012 0.0101 0.76696 0.937 0.6698 0.906 0.3892 0.763 0.45456 0.813 0.46611 0.814 0.32968 0.742 0.53758 0.855 5p gain 24 (28%) 63 0.19698 0.606 0.33182 0.742 0.51443 0.846 0.5802 0.88 0.03689 0.331 0.43382 0.8 0.49918 0.844 0.44769 0.806 5q gain 15 (17%) 72 0.062159 0.444 0.35666 0.747 0.30237 0.726 0.69034 0.906 0.15089 0.538 0.37025 0.758 0.34019 0.742 0.34488 0.742 6p gain 7 (8%) 80 0.076129 0.455 0.094379 0.482 0.068189 0.445 0.38361 0.763 0.071069 0.445 0.96466 1 0.88406 0.973 0.71479 0.92 6q gain 4 (5%) 83 0.1031 0.484 0.63414 0.906 0.40023 0.769 0.6935 0.906 0.67141 0.906 0.93615 0.984 0.67593 0.906 0.75582 0.932 7p gain 25 (29%) 62 0.0145 0.195 0.39447 0.764 0.095449 0.483 0.071249 0.445 0.097389 0.484 0.04267 0.366 0.32104 0.74 0.02361 0.257 7q gain 22 (25%) 65 0.02424 0.257 0.44654 0.806 0.14259 0.524 0.02997 0.291 0.22399 0.631 0.18102 0.576 0.52625 0.854 0.11618 0.498 8p gain 12 (14%) 75 0.04478 0.37 0.52464 0.854 0.66614 0.906 0.75857 0.933 0.13939 0.524 0.03892 0.339 0.59895 0.893 0.24908 0.666 8q gain 14 (16%) 73 0.04865 0.389 0.93548 0.984 0.69924 0.91 0.74772 0.932 0.26264 0.673 0.58628 0.883 0.74354 0.932 0.54289 0.859 9p gain 3 (3%) 84 0.70196 0.911 0.5359 0.855 0.31784 0.74 1 1 0.11367 0.498 0.80935 0.954 0.10089 0.484 0.02488 0.257 9q gain 4 (5%) 83 0.50077 0.844 0.071479 0.445 0.47578 0.821 0.63543 0.906 0.057649 0.423 0.46855 0.814 0.81321 0.955 0.69099 0.906 10p gain 3 (3%) 84 0.080159 0.456 0.7754 0.937 0.8812 0.973 0.9179 0.978 1 1 0.26353 0.673 1 1 0.88826 0.973 10q gain 3 (3%) 84 0.079859 0.456 0.7738 0.937 0.88286 0.973 0.91965 0.978 1 1 0.26495 0.673 1 1 0.8874 0.973 11p gain 11 (13%) 76 0.0077799 0.132 0.66111 0.906 0.29303 0.72 0.091729 0.482 0.38765 0.763 0.66804 0.906 1 1 0.82439 0.955 11q gain 12 (14%) 75 0.0098599 0.154 0.37995 0.763 0.066429 0.445 0.03474 0.321 0.52814 0.854 0.55022 0.869 0.56926 0.873 0.4825 0.83 12p gain 18 (21%) 69 3e-04 0.0161 0.81359 0.955 0.89214 0.973 0.85424 0.963 0.75096 0.932 0.9214 0.978 1 1 0.86194 0.969 12q gain 18 (21%) 69 0.00019 0.0125 0.81601 0.955 0.89218 0.973 0.8538 0.963 0.75063 0.932 0.92072 0.978 1 1 0.86225 0.969 13q gain 5 (6%) 82 0.42388 0.789 0.097539 0.484 0.02653 0.262 0.04545 0.37 0.61008 0.896 0.42842 0.793 0.85124 0.963 0.38884 0.763 15q gain 11 (13%) 76 0.02418 0.257 0.00434 0.0894 0.01982 0.244 0.12805 0.514 0.00323 0.0824 0.077479 0.456 0.77377 0.937 0.22708 0.634 16p gain 17 (20%) 70 0.0069199 0.123 0.56552 0.872 0.01205 0.178 0.067069 0.445 0.17719 0.576 0.1862 0.586 0.63134 0.906 0.079969 0.456 16q gain 16 (18%) 71 0.00279 0.0798 0.80446 0.952 0.02261 0.257 0.10791 0.494 0.56173 0.871 0.65882 0.906 0.87595 0.973 0.37816 0.763 17p gain 7 (8%) 80 0.21835 0.624 1 1 0.4415 0.804 0.68363 0.906 0.69523 0.907 0.11329 0.498 0.46874 0.814 0.24449 0.665 17q gain 17 (20%) 70 0.093929 0.482 0.31822 0.74 0.02058 0.244 0.04558 0.37 0.14518 0.524 0.86862 0.971 0.74189 0.932 0.84478 0.963 18p gain 8 (9%) 79 0.067859 0.445 0.313 0.735 0.11555 0.498 0.17988 0.576 0.12155 0.506 0.13694 0.523 0.6043 0.896 0.13431 0.52 18q gain 4 (5%) 83 0.087139 0.478 1 1 0.2967 0.723 0.63429 0.906 0.03247 0.305 0.083779 0.468 0.60704 0.896 0.1944 0.603 19p gain 14 (16%) 73 0.27484 0.691 0.0352 0.321 0.16292 0.551 0.17423 0.572 0.46492 0.814 0.17477 0.572 0.69307 0.906 0.20537 0.606 19q gain 10 (11%) 77 0.80668 0.953 0.11963 0.506 0.32672 0.741 0.68242 0.906 0.53546 0.855 0.7076 0.915 0.53877 0.855 0.89506 0.974 20p gain 8 (9%) 79 0.69208 0.906 0.7293 0.928 0.38129 0.763 0.78263 0.937 0.58287 0.88 0.44078 0.804 0.64086 0.906 0.66863 0.906 20q gain 10 (11%) 77 0.2055 0.606 0.90656 0.978 0.6394 0.906 0.93744 0.984 0.32394 0.74 0.7486 0.932 0.52493 0.854 0.59383 0.89 21q gain 6 (7%) 81 0.2518 0.668 0.61009 0.896 0.22202 0.629 0.21833 0.624 0.074369 0.454 0.34444 0.742 0.03863 0.339 0.15964 0.546 xp gain 7 (8%) 80 0.13361 0.52 0.35845 0.747 0.24685 0.665 0.77843 0.937 0.78598 0.937 0.96678 1 0.78395 0.937 0.90528 0.978 xq gain 6 (7%) 81 0.23008 0.639 0.50065 0.844 0.15345 0.538 0.64579 0.906 0.48507 0.832 0.83704 0.96 1 1 0.87984 0.973 1p loss 8 (9%) 79 0.02432 0.257 0.22573 0.633 0.41978 0.786 0.9129 0.978 0.28439 0.707 0.20571 0.606 0.053829 0.409 0.64713 0.906 2p loss 6 (7%) 81 0.68713 0.906 0.38415 0.763 0.25633 0.673 0.069449 0.445 0.075289 0.455 0.58234 0.88 0.84951 0.963 0.15937 0.546 2q loss 4 (5%) 83 0.63532 0.906 0.34348 0.742 0.29664 0.723 0.50648 0.845 0.55869 0.871 0.39188 0.764 1 1 1 1 3p loss 8 (9%) 79 0.3663 0.756 0.091039 0.482 0.16765 0.561 0.11858 0.505 0.46249 0.814 0.71236 0.919 0.19909 0.606 0.062199 0.444 3q loss 6 (7%) 81 0.72094 0.924 0.090359 0.482 0.18013 0.576 0.41591 0.784 1 1 0.50604 0.845 0.656 0.906 0.62152 0.906 4p loss 32 (37%) 55 2e-05 0.00395 0.32291 0.74 0.27171 0.687 0.0041 0.0894 0.12856 0.514 0.33369 0.742 0.38736 0.763 0.5135 0.846 4q loss 33 (38%) 54 2e-05 0.00395 0.10032 0.484 0.00384 0.0894 0.00042 0.0191 0.057909 0.423 0.14438 0.524 0.7753 0.937 0.092129 0.482 5p loss 4 (5%) 83 0.50049 0.844 0.69257 0.906 0.36834 0.757 0.63649 0.906 0.35728 0.747 0.9364 0.984 1 1 0.44473 0.805 5q loss 9 (10%) 78 0.02563 0.257 0.83796 0.96 0.49482 0.844 0.10468 0.484 0.36595 0.756 0.668 0.906 0.41026 0.78 0.91602 0.978 6p loss 9 (10%) 78 0.83601 0.96 0.32076 0.74 0.24982 0.666 0.50303 0.844 0.90316 0.978 0.17129 0.566 0.20663 0.606 0.11046 0.495 6q loss 29 (33%) 58 0.00334 0.0824 0.21486 0.624 0.39443 0.764 0.65132 0.906 0.65187 0.906 0.52164 0.853 0.11231 0.498 0.081359 0.459 8p loss 13 (15%) 74 0.87121 0.971 0.69016 0.906 0.66488 0.906 0.74956 0.932 0.32761 0.741 0.74953 0.932 0.74631 0.932 0.28241 0.705 8q loss 4 (5%) 83 0.10263 0.484 0.3751 0.76 0.51142 0.846 0.55754 0.871 0.16426 0.553 0.12226 0.506 1 1 0.1038 0.484 9p loss 28 (32%) 59 5e-05 0.00592 0.01518 0.2 0.04322 0.366 0.01111 0.169 0.95716 1 0.49274 0.843 0.91527 0.978 0.15349 0.538 9q loss 21 (24%) 66 0.00164 0.0571 0.20532 0.606 0.14285 0.524 0.16105 0.548 0.95019 0.996 0.53633 0.855 0.57651 0.879 0.26335 0.673 10p loss 24 (28%) 63 0.00453 0.0894 0.00072999 0.027 0.13208 0.52 0.13568 0.522 0.86996 0.971 0.30498 0.726 0.70728 0.915 0.73104 0.929 10q loss 19 (22%) 68 0.02315 0.257 0.01648 0.212 0.50184 0.844 0.32184 0.74 0.25714 0.673 0.72025 0.924 1 1 0.83713 0.96 11p loss 4 (5%) 83 0.68155 0.906 0.82611 0.955 0.29922 0.725 0.265 0.673 0.82021 0.955 0.39468 0.764 0.56444 0.872 0.91076 0.978 11q loss 5 (6%) 82 0.57772 0.879 0.61791 0.905 0.00424 0.0894 0.00283 0.0798 0.84585 0.963 0.3557 0.747 0.56155 0.871 0.91382 0.978 12p loss 4 (5%) 83 0.2584 0.673 0.071069 0.445 0.47464 0.821 0.46401 0.814 0.29052 0.72 0.81736 0.955 0.46525 0.814 0.59916 0.893 13q loss 33 (38%) 54 0.10457 0.484 0.73775 0.932 0.169 0.562 0.66228 0.906 0.75348 0.932 0.18775 0.588 0.02039 0.244 0.46874 0.814 14q loss 35 (40%) 52 4e-04 0.0191 0.35473 0.747 0.00023 0.0136 9.9999e-06 0.00395 0.04951 0.391 0.00059999 0.0253 0.014 0.195 0.00174 0.0572 15q loss 11 (13%) 76 0.11483 0.498 0.75937 0.933 0.27554 0.691 0.29991 0.725 0.3281 0.741 0.30431 0.726 0.74612 0.932 0.40489 0.776 16p loss 7 (8%) 80 0.0095999 0.154 0.19338 0.603 0.53091 0.854 0.34418 0.742 0.41714 0.784 0.3622 0.752 1 1 1 1 16q loss 10 (11%) 77 0.051219 0.396 0.90702 0.978 0.21807 0.624 0.45341 0.813 0.69205 0.906 0.12648 0.514 1 1 0.87833 0.973 17p loss 23 (26%) 64 0.34867 0.745 0.38135 0.763 0.76435 0.937 0.62791 0.906 0.15031 0.538 0.13961 0.524 0.5114 0.846 0.26084 0.673 17q loss 7 (8%) 80 0.55952 0.871 0.15523 0.541 0.66933 0.906 0.72862 0.928 0.24648 0.665 0.52951 0.854 0.42155 0.787 0.21363 0.623 18p loss 9 (10%) 78 0.14003 0.524 0.78106 0.937 0.67504 0.906 0.69143 0.906 0.33289 0.742 0.75455 0.932 0.39957 0.769 0.6859 0.906 18q loss 14 (16%) 73 0.41106 0.78 0.68655 0.906 0.84683 0.963 0.86459 0.969 0.1235 0.508 0.093589 0.482 0.33838 0.742 0.18088 0.576 19p loss 4 (5%) 83 0.6833 0.906 0.20055 0.606 0.55845 0.871 0.46284 0.814 1 1 0.34837 0.745 0.20322 0.606 0.37134 0.758 19q loss 7 (8%) 80 0.559 0.871 0.051459 0.396 1 1 0.93395 0.984 0.78667 0.937 0.79197 0.94 0.3127 0.735 0.82287 0.955 20p loss 14 (16%) 73 0.02566 0.257 0.10933 0.494 0.14415 0.524 0.5877 0.883 0.33994 0.742 0.72266 0.924 0.56769 0.873 0.12707 0.514 20q loss 3 (3%) 84 0.24008 0.658 0.3409 0.742 0.78927 0.938 0.20288 0.606 0.25803 0.673 0.01846 0.233 1 1 0.4427 0.804 21q loss 11 (13%) 76 0.10906 0.494 0.01296 0.187 0.22017 0.627 0.079779 0.456 0.65848 0.906 0.29315 0.72 0.84791 0.963 0.82556 0.955 22q loss 67 (77%) 20 0.0053399 0.102 4e-05 0.00592 0.056139 0.421 0.00446 0.0894 1 1 0.64515 0.906 0.13351 0.52 0.82998 0.958 xp loss 27 (31%) 60 0.0059899 0.111 9.9999e-05 0.00987 0.068369 0.445 0.0070899 0.123 0.091389 0.482 0.41704 0.784 0.073999 0.454 0.30525 0.726 xq loss 28 (32%) 59 0.00199 0.062 0.00016 0.0118 0.086619 0.478 0.00329 0.0824 0.1518 0.538 0.4084 0.78 0.067959 0.445 0.31148 0.735