Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.207 0.402 -9999.0 0.0 -0.899 18.0 18.0 IHH -0.058 0.137 -9999.0 0.0 -0.517 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.03 0.145 -9999.0 0.0 -0.411 10.0 10.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.144 0.408 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.093 0.236 -9999.0 0.0 -0.618 11.0 11.0 SMO -0.105 0.249 -9999.0 0.0 -0.658 11.0 11.0 AKT1 -0.022 0.107 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.027 0.149 -9999.0 0.0 -0.571 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.103 0.245 -9999.0 0.0 -0.646 11.0 11.0 STIL -0.101 0.24 -9999.0 0.0 -0.653 11.0 11.0 DHH N/PTCH2 -0.091 0.201 -9999.0 0.0 -0.436 21.0 21.0 DHH N/PTCH1 -0.14 0.282 -9999.0 0.0 -0.749 12.0 12.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.031 0.162 -9999.0 0.0 -0.62 6.0 6.0 PTHLH -0.225 0.432 -9999.0 0.0 -0.974 18.0 18.0 determination of left/right symmetry -0.103 0.245 -9999.0 0.0 -0.646 11.0 11.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.221 0.424 -9999.0 0.0 -0.957 18.0 18.0 IHH N/Hhip -0.265 0.254 -9999.0 0.0 -0.49 47.0 47.0 DHH N/Hhip -0.237 0.263 -9999.0 0.0 -0.472 45.0 45.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.103 0.245 -9999.0 0.0 -0.646 11.0 11.0 pancreas development -0.296 0.305 -9999.0 0.0 -0.592 44.0 44.0 HHAT 0.006 0.071 -9999.0 0.0 -0.653 1.0 1.0 PI3K 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.052 0.195 -9999.0 0.0 -0.62 9.0 9.0 somite specification -0.103 0.245 -9999.0 0.0 -0.646 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.11 0.244 -9999.0 0.0 -0.687 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.054 0.14 -9999.0 0.0 -0.315 19.0 19.0 SHH Np/Cholesterol/Megalin -0.093 0.19 -9999.0 0.0 -0.387 24.0 24.0 SHH 0.001 0.081 -9999.0 0.0 -0.425 3.0 3.0 catabolic process -0.134 0.287 -9999.0 0.0 -0.764 12.0 12.0 SMO/Vitamin D3 -0.101 0.239 -9999.0 0.0 -0.633 11.0 11.0 SHH Np/Cholesterol/Hhip -0.171 0.196 -9999.0 0.0 -0.354 44.0 44.0 LRP2 -0.16 0.288 -9999.0 0.0 -0.636 23.0 23.0 receptor-mediated endocytosis -0.18 0.247 -9999.0 0.0 -0.629 15.0 15.0 SHH Np/Cholesterol/BOC -0.015 0.104 -9999.0 0.0 -0.318 9.0 9.0 SHH Np/Cholesterol/CDO -0.032 0.16 -9999.0 0.0 -0.478 9.0 9.0 mesenchymal cell differentiation 0.17 0.194 0.352 44.0 -9999.0 0.0 44.0 mol:Vitamin D3 -0.109 0.247 -9999.0 0.0 -0.69 10.0 10.0 IHH N/PTCH2 -0.102 0.203 -9999.0 0.0 -0.494 16.0 16.0 CDON -0.056 0.204 -9999.0 0.0 -0.653 9.0 9.0 IHH N/PTCH1 -0.135 0.29 -9999.0 0.0 -0.77 12.0 12.0 Megalin/LRPAP1 -0.109 0.216 -9999.0 0.0 -0.466 23.0 23.0 PTCH2 -0.094 0.227 -9999.0 0.0 -0.567 16.0 16.0 SHH Np/Cholesterol -0.005 0.062 -9999.0 0.0 -0.331 3.0 3.0 PTCH1 -0.135 0.289 -9999.0 0.0 -0.768 12.0 12.0 HHIP -0.296 0.305 -9999.0 0.0 -0.593 44.0 44.0