Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.034 0.127 -9999.0 0.0 -0.273 19.0 19.0 epithelial cell differentiation -0.063 0.132 -9999.0 0.0 -0.339 16.0 16.0 CYFIP2 0.006 0.071 -9999.0 0.0 -0.653 1.0 1.0 ENAH 0.002 0.14 -9999.0 0.0 -0.41 5.0 5.0 EGFR -0.032 0.17 -9999.0 0.0 -0.653 6.0 6.0 EPHA2 0.006 0.071 -9999.0 0.0 -0.653 1.0 1.0 MYO6 -0.034 0.145 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.061 -9999.0 0.0 -0.405 2.0 2.0 AQP5 -0.139 0.199 -9999.0 0.0 -0.535 13.0 13.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.026 0.137 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.065 0.172 -9999.0 0.0 -0.615 2.0 2.0 EGF -0.058 0.199 -9999.0 0.0 -0.604 10.0 10.0 NCKAP1 0.006 0.071 -9999.0 0.0 -0.653 1.0 1.0 AQP3 -0.101 0.173 -9999.0 0.0 -0.589 6.0 6.0 cortical microtubule organization -0.063 0.132 -9999.0 0.0 -0.339 16.0 16.0 GO:0000145 -0.024 0.131 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.064 0.133 -9999.0 0.0 -0.342 16.0 16.0 MLLT4 -0.009 0.122 -9999.0 0.0 -0.653 3.0 3.0 ARF6/GDP -0.067 0.159 -9999.0 0.0 -0.599 5.0 5.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.009 0.116 -9999.0 0.0 -0.435 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.133 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.026 0.139 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.023 0.099 -9999.0 0.0 -0.398 5.0 5.0 CDH1 -0.11 0.259 -9999.0 0.0 -0.653 16.0 16.0 EGFR/EGFR/EGF/EGF -0.11 0.178 -9999.0 0.0 -0.717 3.0 3.0 RhoA/GDP -0.059 0.122 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.025 0.139 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.031 0.166 -9999.0 0.0 -0.635 6.0 6.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.031 0.166 -9999.0 0.0 -0.636 6.0 6.0 IGF1 -0.073 0.218 -9999.0 0.0 -0.612 12.0 12.0 DIAPH1 -0.019 0.123 -9999.0 0.0 -0.812 2.0 2.0 Wnt receptor signaling pathway 0.063 0.132 0.339 16.0 -9999.0 0.0 16.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.068 0.159 -9999.0 0.0 -0.599 5.0 5.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.026 0.142 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.025 0.156 -9999.0 0.0 -0.653 5.0 5.0 LPP -0.021 0.137 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.079 0.186 -9999.0 0.0 -0.697 5.0 5.0 SEC6/SEC8 -0.061 0.138 -9999.0 0.0 -0.582 3.0 3.0 MGAT3 -0.067 0.175 -9999.0 0.0 -0.629 2.0 2.0 HGF/MET -0.157 0.198 -9999.0 0.0 -0.676 6.0 6.0 HGF -0.14 0.265 -9999.0 0.0 -0.59 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.034 0.128 -9999.0 0.0 -0.275 19.0 19.0 actin cable formation 0.023 0.132 -9999.0 0.0 -0.365 5.0 5.0 KIAA1543 -0.067 0.215 -9999.0 0.0 -0.621 8.0 8.0 KIFC3 -0.026 0.139 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.026 0.139 -9999.0 0.0 -0.318 16.0 16.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.063 0.132 -9999.0 0.0 -0.339 16.0 16.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.139 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.026 0.139 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.009 0.122 -9999.0 0.0 -0.653 3.0 3.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.158 -9999.0 0.0 -0.503 5.0 5.0 adherens junction assembly -0.046 0.211 -9999.0 0.0 -0.593 8.0 8.0 IGF-1R heterotetramer/IGF1 -0.117 0.173 -9999.0 0.0 -0.62 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.004 0.092 -9999.0 0.0 -0.48 3.0 3.0 MET -0.056 0.204 -9999.0 0.0 -0.653 9.0 9.0 PLEKHA7 -0.041 0.165 -9999.0 0.0 -0.629 2.0 2.0 mol:GTP -0.025 0.107 -9999.0 0.0 -0.431 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.004 0.155 -9999.0 0.0 -0.55 3.0 3.0 cortical actin cytoskeleton stabilization -0.034 0.127 -9999.0 0.0 -0.273 19.0 19.0 regulation of cell-cell adhesion -0.025 0.139 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.034 0.128 -9999.0 0.0 -0.275 19.0 19.0