Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Nephrin/Neph1 signaling in the kidney podocyte 20.0 686.0 34.0 -0.273 0.014 1000.0 -1000.0 -0.062 -1000.0 Ephrin A reverse signaling 20.0 146.0 7.0 -0.167 -0.0 1000.0 -1000.0 -0.031 -1000.0 TCGA08_retinoblastoma 18.0 146.0 8.0 -0.135 0.085 1000.0 -1000.0 -0.022 -1000.0 Syndecan-1-mediated signaling events 13.0 475.0 34.0 -0.288 0.014 1000.0 -1000.0 -0.057 -1000.0 Signaling events mediated by the Hedgehog family 13.0 715.0 52.0 -0.296 0.17 1000.0 -1000.0 -0.077 -1000.0 IL4-mediated signaling events 12.0 1100.0 91.0 -0.76 0.683 1000.0 -1000.0 -0.16 -1000.0 p75(NTR)-mediated signaling 10.0 1373.0 125.0 -0.332 0.027 1000.0 -1000.0 -0.109 -1000.0 Glucocorticoid receptor regulatory network 10.0 1165.0 114.0 -0.718 0.347 1000.0 -1000.0 -0.08 -1000.0 Signaling mediated by p38-alpha and p38-beta 10.0 445.0 44.0 -0.125 0.014 1000.0 -1000.0 -0.048 -1000.0 E-cadherin signaling events 10.0 53.0 5.0 -0.11 0.014 1000.0 -1000.0 -0.041 -1000.0 amb2 Integrin signaling 9.0 746.0 82.0 -0.299 0.014 1000.0 -1000.0 -0.082 -1000.0 Signaling events regulated by Ret tyrosine kinase 9.0 795.0 82.0 -0.207 0.014 1000.0 -1000.0 -0.092 -1000.0 Endothelins 9.0 882.0 96.0 -0.249 0.014 1000.0 -1000.0 -0.086 -1000.0 Integrins in angiogenesis 9.0 827.0 84.0 -0.262 0.027 1000.0 -1000.0 -0.097 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 9.0 646.0 68.0 -0.38 0.081 1000.0 -1000.0 -0.124 -1000.0 IL23-mediated signaling events 9.0 560.0 60.0 -0.468 0.014 1000.0 -1000.0 -0.161 -1000.0 HIF-1-alpha transcription factor network 8.0 627.0 76.0 -0.309 0.025 1000.0 -1000.0 -0.136 -1000.0 FOXA2 and FOXA3 transcription factor networks 8.0 372.0 46.0 -0.38 0.024 1000.0 -1000.0 -0.083 -1000.0 Reelin signaling pathway 8.0 491.0 56.0 -0.268 0.021 1000.0 -1000.0 -0.077 -1000.0 Ephrin B reverse signaling 8.0 417.0 48.0 -0.177 0.029 1000.0 -1000.0 -0.065 -1000.0 TCR signaling in naïve CD8+ T cells 8.0 767.0 93.0 -0.162 0.077 1000.0 -1000.0 -0.082 -1000.0 Calcium signaling in the CD4+ TCR pathway 8.0 250.0 31.0 -0.304 0.014 1000.0 -1000.0 -0.089 -1000.0 Caspase cascade in apoptosis 7.0 519.0 74.0 -0.136 0.067 1000.0 -1000.0 -0.04 -1000.0 IL12-mediated signaling events 7.0 658.0 87.0 -0.28 0.027 1000.0 -1000.0 -0.127 -1000.0 Thromboxane A2 receptor signaling 7.0 765.0 105.0 -0.191 0.054 1000.0 -1000.0 -0.06 -1000.0 BMP receptor signaling 7.0 577.0 81.0 -0.226 0.042 1000.0 -1000.0 -0.098 -1000.0 Glypican 1 network 7.0 336.0 48.0 -0.205 0.018 1000.0 -1000.0 -0.047 -1000.0 Nongenotropic Androgen signaling 7.0 365.0 52.0 -0.133 0.066 1000.0 -1000.0 -0.062 -1000.0 Wnt signaling 7.0 49.0 7.0 -0.096 0.014 1000.0 -1000.0 -0.025 -1000.0 BCR signaling pathway 7.0 706.0 99.0 -0.248 0.016 1000.0 -1000.0 -0.095 -1000.0 Syndecan-4-mediated signaling events 7.0 521.0 67.0 -0.169 0.017 1000.0 -1000.0 -0.099 -1000.0 LPA4-mediated signaling events 6.0 72.0 12.0 -0.097 0.017 1000.0 -1000.0 -0.03 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 6.0 518.0 85.0 -0.14 0.014 1000.0 -1000.0 -0.08 -1000.0 TCGA08_p53 6.0 42.0 7.0 -0.102 0.056 1000.0 -1000.0 -0.018 -1000.0 EPHB forward signaling 6.0 530.0 85.0 -0.146 0.089 1000.0 -1000.0 -0.095 -1000.0 E-cadherin signaling in the nascent adherens junction 6.0 456.0 76.0 -0.11 0.021 1000.0 -1000.0 -0.085 -1000.0 EGFR-dependent Endothelin signaling events 6.0 136.0 21.0 -0.125 0.021 1000.0 -1000.0 -0.065 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 6.0 826.0 120.0 -0.234 0.175 1000.0 -1000.0 -0.08 -1000.0 ErbB2/ErbB3 signaling events 5.0 338.0 65.0 -0.151 0.022 1000.0 -1000.0 -0.068 -1000.0 Coregulation of Androgen receptor activity 5.0 388.0 76.0 -0.158 0.024 1000.0 -1000.0 -0.04 -1000.0 ErbB4 signaling events 5.0 375.0 69.0 -0.196 0.158 1000.0 -1000.0 -0.097 -1000.0 Visual signal transduction: Cones 5.0 204.0 38.0 -0.083 0.014 1000.0 -1000.0 -0.059 -1000.0 Osteopontin-mediated events 5.0 196.0 38.0 -0.138 0.018 1000.0 -1000.0 -0.109 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 5.0 320.0 54.0 -0.195 0.029 1000.0 -1000.0 -0.1 -1000.0 Noncanonical Wnt signaling pathway 5.0 134.0 26.0 -0.112 0.014 1000.0 -1000.0 -0.054 -1000.0 Effects of Botulinum toxin 5.0 145.0 26.0 -0.124 0.014 1000.0 -1000.0 -0.063 -1000.0 Glypican 2 network 5.0 22.0 4.0 -0.022 -0.021 1000.0 -1000.0 -0.023 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 5.0 734.0 125.0 -0.097 0.021 1000.0 -1000.0 -0.102 -1000.0 IL27-mediated signaling events 5.0 259.0 51.0 -0.174 0.071 1000.0 -1000.0 -0.084 -1000.0 IL6-mediated signaling events 5.0 426.0 75.0 -0.21 0.056 1000.0 -1000.0 -0.092 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 5.0 385.0 74.0 -0.157 0.063 1000.0 -1000.0 -0.091 -1000.0 Angiopoietin receptor Tie2-mediated signaling 5.0 502.0 88.0 -0.261 0.016 1000.0 -1000.0 -0.109 -1000.0 Visual signal transduction: Rods 5.0 278.0 52.0 -0.177 0.014 1000.0 -1000.0 -0.092 -1000.0 Class IB PI3K non-lipid kinase events 5.0 15.0 3.0 -0.022 -1000.0 1000.0 -1000.0 -0.013 -1000.0 Syndecan-2-mediated signaling events 4.0 328.0 69.0 -0.139 0.036 1000.0 -1000.0 -0.05 -1000.0 Arf6 signaling events 4.0 307.0 62.0 -0.263 0.016 1000.0 -1000.0 -0.065 -1000.0 Signaling events mediated by PTP1B 4.0 317.0 76.0 -0.158 0.025 1000.0 -1000.0 -0.083 -1000.0 Presenilin action in Notch and Wnt signaling 4.0 272.0 61.0 -0.268 0.039 1000.0 -1000.0 -0.069 -1000.0 Fc-epsilon receptor I signaling in mast cells 4.0 439.0 97.0 -0.138 0.034 1000.0 -1000.0 -0.081 -1000.0 PDGFR-alpha signaling pathway 4.0 181.0 44.0 -0.221 0.028 1000.0 -1000.0 -0.063 -1000.0 S1P1 pathway 4.0 157.0 36.0 -0.098 0.014 1000.0 -1000.0 -0.062 -1000.0 FAS signaling pathway (CD95) 4.0 211.0 47.0 -0.259 0.028 1000.0 -1000.0 -0.043 -1000.0 Syndecan-3-mediated signaling events 4.0 158.0 35.0 -0.105 0.021 1000.0 -1000.0 -0.072 -1000.0 IGF1 pathway 4.0 264.0 57.0 -0.082 0.021 1000.0 -1000.0 -0.099 -1000.0 FOXM1 transcription factor network 4.0 204.0 51.0 -0.145 0.14 1000.0 -1000.0 -0.186 -1000.0 Regulation of nuclear SMAD2/3 signaling 3.0 459.0 136.0 -0.226 0.222 1000.0 -1000.0 -0.069 -1000.0 BARD1 signaling events 3.0 197.0 57.0 -0.055 0.045 1000.0 -1000.0 -0.066 -1000.0 Hedgehog signaling events mediated by Gli proteins 3.0 241.0 65.0 -0.245 0.071 1000.0 -1000.0 -0.065 -1000.0 Nectin adhesion pathway 3.0 243.0 63.0 -0.13 0.026 1000.0 -1000.0 -0.071 -1000.0 HIF-2-alpha transcription factor network 3.0 133.0 43.0 -0.127 0.023 1000.0 -1000.0 -0.086 -1000.0 Signaling mediated by p38-gamma and p38-delta 3.0 49.0 15.0 -0.017 0.019 1000.0 -1000.0 -0.027 -1000.0 Retinoic acid receptors-mediated signaling 3.0 206.0 58.0 -0.143 0.02 1000.0 -1000.0 -0.076 -1000.0 IL2 signaling events mediated by PI3K 3.0 186.0 58.0 -0.094 0.036 1000.0 -1000.0 -0.085 -1000.0 Canonical Wnt signaling pathway 3.0 192.0 51.0 -0.268 0.052 1000.0 -1000.0 -0.061 -1000.0 LPA receptor mediated events 3.0 363.0 102.0 -0.145 0.039 1000.0 -1000.0 -0.092 -1000.0 IL2 signaling events mediated by STAT5 3.0 80.0 22.0 -0.069 0.015 1000.0 -1000.0 -0.04 -1000.0 VEGFR1 specific signals 3.0 185.0 56.0 -0.092 0.014 1000.0 -1000.0 -0.084 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 3.0 106.0 33.0 -0.138 0.026 1000.0 -1000.0 -0.061 -1000.0 Regulation of Androgen receptor activity 3.0 242.0 70.0 -0.315 0.027 1000.0 -1000.0 -0.068 -1000.0 Aurora B signaling 3.0 234.0 67.0 -0.128 0.014 1000.0 -1000.0 -0.075 -1000.0 Sphingosine 1-phosphate (S1P) pathway 2.0 59.0 28.0 -0.037 0.025 1000.0 -1000.0 -0.04 -1000.0 PLK2 and PLK4 events 2.0 8.0 3.0 -0.008 0.002 1000.0 -1000.0 -0.022 -1000.0 JNK signaling in the CD4+ TCR pathway 2.0 44.0 17.0 -0.039 0.027 1000.0 -1000.0 -0.061 -1000.0 Cellular roles of Anthrax toxin 2.0 89.0 39.0 -0.065 0.018 1000.0 -1000.0 -0.03 -1000.0 Aurora C signaling 2.0 16.0 7.0 -0.021 0.0 1000.0 -1000.0 -0.029 -1000.0 IFN-gamma pathway 2.0 155.0 68.0 -0.162 0.036 1000.0 -1000.0 -0.102 -1000.0 Signaling events mediated by HDAC Class III 2.0 99.0 40.0 -0.131 0.03 1000.0 -1000.0 -0.045 -1000.0 TRAIL signaling pathway 2.0 137.0 48.0 -0.04 0.031 1000.0 -1000.0 -0.067 -1000.0 IL1-mediated signaling events 2.0 160.0 62.0 -0.094 0.064 1000.0 -1000.0 -0.098 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 2.0 132.0 52.0 -0.153 0.034 1000.0 -1000.0 -0.06 -1000.0 Regulation of p38-alpha and p38-beta 2.0 133.0 54.0 -0.158 0.033 1000.0 -1000.0 -0.062 -1000.0 Regulation of Telomerase 2.0 285.0 102.0 -0.163 0.036 1000.0 -1000.0 -0.099 -1000.0 Plasma membrane estrogen receptor signaling 2.0 218.0 86.0 -0.073 0.04 1000.0 -1000.0 -0.074 -1000.0 S1P3 pathway 2.0 101.0 42.0 -0.095 0.021 1000.0 -1000.0 -0.034 -1000.0 Rapid glucocorticoid signaling 2.0 41.0 20.0 -0.05 0.014 1000.0 -1000.0 -0.041 -1000.0 PDGFR-beta signaling pathway 2.0 247.0 97.0 -0.087 0.023 1000.0 -1000.0 -0.093 -1000.0 E-cadherin signaling in keratinocytes 2.0 127.0 43.0 -0.11 0.016 1000.0 -1000.0 -0.067 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 2.0 191.0 78.0 -0.056 0.047 1000.0 -1000.0 -0.066 -1000.0 p38 MAPK signaling pathway 2.0 108.0 44.0 -0.149 0.027 1000.0 -1000.0 -0.071 -1000.0 Ras signaling in the CD4+ TCR pathway 2.0 49.0 17.0 -0.038 0.022 1000.0 -1000.0 -0.041 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 8.0 5.0 -0.013 0.021 1000.0 -1000.0 -0.02 -1000.0 Aurora A signaling 1.0 102.0 60.0 -0.125 0.042 1000.0 -1000.0 -0.068 -1000.0 Arf6 downstream pathway 1.0 47.0 43.0 -0.031 0.027 1000.0 -1000.0 -0.035 -1000.0 PLK1 signaling events 1.0 121.0 85.0 -0.031 0.026 1000.0 -1000.0 -0.047 -1000.0 Insulin-mediated glucose transport 1.0 43.0 32.0 -0.138 0.034 1000.0 -1000.0 -0.067 -1000.0 Ceramide signaling pathway 1.0 116.0 76.0 -0.073 0.034 1000.0 -1000.0 -0.062 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 62.0 37.0 -0.052 0.037 1000.0 -1000.0 -0.056 -1000.0 S1P5 pathway 1.0 26.0 17.0 -0.029 0.026 1000.0 -1000.0 -0.032 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 160.0 83.0 -0.147 0.05 1000.0 -1000.0 -0.081 -1000.0 FoxO family signaling 1.0 97.0 64.0 -0.138 0.103 1000.0 -1000.0 -0.071 -1000.0 Atypical NF-kappaB pathway 1.0 49.0 31.0 -0.046 0.029 1000.0 -1000.0 -0.035 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 1.0 66.0 45.0 -0.059 0.057 1000.0 -1000.0 -0.096 -1000.0 TCGA08_rtk_signaling 1.0 51.0 26.0 -0.056 0.041 1000.0 -1000.0 -0.02 -1000.0 Class I PI3K signaling events 1.0 84.0 73.0 -0.158 0.041 1000.0 -1000.0 -0.069 -1000.0 Insulin Pathway 1.0 124.0 74.0 -0.133 0.031 1000.0 -1000.0 -0.095 -1000.0 Signaling events mediated by PRL 1.0 62.0 34.0 -0.063 0.021 1000.0 -1000.0 -0.029 -1000.0 S1P4 pathway 1.0 44.0 25.0 -0.029 0.021 1000.0 -1000.0 -0.048 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 9.0 23.0 -0.009 0.045 1000.0 -1000.0 -0.06 -1000.0 Canonical NF-kappaB pathway 0.0 24.0 39.0 -0.024 0.079 1000.0 -1000.0 -0.08 -1000.0 Signaling events mediated by HDAC Class II 0.0 53.0 75.0 -0.05 0.039 1000.0 -1000.0 -0.068 -1000.0 Circadian rhythm pathway 0.0 21.0 22.0 -0.011 0.038 1000.0 -1000.0 -0.045 -1000.0 EPO signaling pathway 0.0 30.0 55.0 -0.029 0.079 1000.0 -1000.0 -0.094 -1000.0 mTOR signaling pathway 0.0 37.0 53.0 -0.012 0.033 1000.0 -1000.0 -0.061 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 55.0 68.0 -0.138 0.054 1000.0 -1000.0 -0.058 -1000.0 ceramide signaling pathway 0.0 40.0 49.0 -0.023 0.046 1000.0 -1000.0 -0.053 -1000.0 Signaling events mediated by HDAC Class I 0.0 75.0 104.0 -0.05 0.042 1000.0 -1000.0 -0.069 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 28.0 36.0 -0.043 0.043 1000.0 -1000.0 -0.074 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 3.0 27.0 0.0 0.036 1000.0 -1000.0 -0.056 -1000.0 Arf6 trafficking events 0.0 28.0 71.0 -0.046 0.047 1000.0 -1000.0 -0.077 -1000.0 Arf1 pathway 0.0 6.0 54.0 -0.004 0.038 1000.0 -1000.0 -0.046 -1000.0 Alternative NF-kappaB pathway 0.0 2.0 13.0 -0.0 0.015 1000.0 -1000.0 -0.063 -1000.0 Total 569 35507 7203 -19.1448992266 -994.172653819 131000 -131000 -9.09726459146 -131000