Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.108 0.246 -9999.0 0.0 -0.561 16.0 16.0 IHH -0.026 0.086 -9999.0 0.0 -0.225 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.0 0.076 -9999.0 0.0 -0.351 3.0 3.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.076 0.349 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.036 0.149 -9999.0 0.0 -0.506 3.0 3.0 SMO -0.052 0.146 -9999.0 0.0 -0.532 3.0 3.0 AKT1 -0.009 0.105 -9999.0 0.0 -0.377 4.0 4.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.006 0.085 -9999.0 0.0 -0.292 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.046 0.147 -9999.0 0.0 -0.522 3.0 3.0 STIL -0.039 0.15 -9999.0 0.0 -0.387 6.0 6.0 DHH N/PTCH2 -0.025 0.126 -9999.0 0.0 -0.235 20.0 20.0 DHH N/PTCH1 -0.065 0.17 -9999.0 0.0 -0.389 13.0 13.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.117 -9999.0 0.0 -0.414 6.0 6.0 PTHLH -0.125 0.308 -9999.0 0.0 -0.842 11.0 11.0 determination of left/right symmetry -0.046 0.147 -9999.0 0.0 -0.522 3.0 3.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.123 0.303 -9999.0 0.0 -0.83 11.0 11.0 IHH N/Hhip -0.145 0.167 -9999.0 0.0 -0.289 44.0 44.0 DHH N/Hhip -0.121 0.182 -9999.0 0.0 -0.274 44.0 44.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.046 0.147 -9999.0 0.0 -0.522 3.0 3.0 pancreas development -0.164 0.205 -9999.0 0.0 -0.347 44.0 44.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.12 -9999.0 0.0 -0.391 7.0 7.0 somite specification -0.046 0.147 -9999.0 0.0 -0.522 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.055 0.134 -9999.0 0.0 -0.407 5.0 5.0 SHH Np/Cholesterol/PTCH2 -0.013 0.071 -9999.0 0.0 -0.282 2.0 2.0 SHH Np/Cholesterol/Megalin -0.049 0.133 -9999.0 0.0 -0.289 19.0 19.0 SHH -0.006 0.028 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.068 0.168 -9999.0 0.0 -0.375 16.0 16.0 SMO/Vitamin D3 -0.035 0.149 -9999.0 0.0 -0.496 3.0 3.0 SHH Np/Cholesterol/Hhip -0.073 0.123 -9999.0 0.0 -0.272 18.0 18.0 LRP2 -0.101 0.219 -9999.0 0.0 -0.453 23.0 23.0 receptor-mediated endocytosis -0.087 0.171 -9999.0 0.0 -0.509 5.0 5.0 SHH Np/Cholesterol/BOC 0.006 0.053 -9999.0 0.0 -0.282 1.0 1.0 SHH Np/Cholesterol/CDO -0.013 0.103 -9999.0 0.0 -0.31 9.0 9.0 mesenchymal cell differentiation 0.072 0.123 0.27 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.034 0.156 -9999.0 0.0 -0.408 5.0 5.0 IHH N/PTCH2 -0.037 0.117 -9999.0 0.0 -0.249 16.0 16.0 CDON -0.028 0.16 -9999.0 0.0 -0.496 9.0 9.0 IHH N/PTCH1 -0.055 0.176 -9999.0 0.0 -0.377 16.0 16.0 Megalin/LRPAP1 -0.057 0.166 -9999.0 0.0 -0.358 19.0 19.0 PTCH2 -0.031 0.127 -9999.0 0.0 -0.286 16.0 16.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.069 0.169 -9999.0 0.0 -0.376 16.0 16.0 HHIP -0.164 0.206 -9999.0 0.0 -0.347 44.0 44.0