Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	19.0	647.0	34.0	-0.157	0.029	1000.0	-1000.0	-0.024	-1000.0
Ephrin A  reverse signaling	18.0	128.0	7.0	-0.087	0.002	1000.0	-1000.0	-0.003	-1000.0
Syndecan-1-mediated signaling events	12.0	439.0	34.0	-0.161	0.028	1000.0	-1000.0	-0.041	-1000.0
IL4-mediated signaling events	11.0	1004.0	91.0	-0.621	0.535	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by the Hedgehog family	10.0	522.0	52.0	-0.164	0.072	1000.0	-1000.0	-0.044	-1000.0
Ephrin B reverse signaling	10.0	482.0	48.0	-0.169	0.028	1000.0	-1000.0	-0.025	-1000.0
Endothelins	10.0	1050.0	96.0	-0.186	0.029	1000.0	-1000.0	-0.049	-1000.0
TCGA08_retinoblastoma	10.0	87.0	8.0	-0.047	0.084	1000.0	-1000.0	-0.002	-1000.0
p75(NTR)-mediated signaling	9.0	1174.0	125.0	-0.178	0.073	1000.0	-1000.0	-0.051	-1000.0
Glucocorticoid receptor regulatory network	9.0	1126.0	114.0	-0.53	0.261	1000.0	-1000.0	-0.047	-1000.0
Signaling events regulated by Ret tyrosine kinase	9.0	773.0	82.0	-0.097	0.029	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling events	9.0	47.0	5.0	-0.058	0.025	1000.0	-1000.0	0.007	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	363.0	44.0	-0.085	0.028	1000.0	-1000.0	-0.022	-1000.0
Integrins in angiogenesis	8.0	710.0	84.0	-0.159	0.053	1000.0	-1000.0	-0.042	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	812.0	93.0	-0.125	0.039	1000.0	-1000.0	-0.044	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	266.0	31.0	-0.204	0.027	1000.0	-1000.0	-0.044	-1000.0
Wnt signaling	8.0	56.0	7.0	-0.045	0.027	1000.0	-1000.0	-0.015	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	8.0	643.0	74.0	-0.076	0.047	1000.0	-1000.0	-0.063	-1000.0
IL23-mediated signaling events	8.0	523.0	60.0	-0.392	0.028	1000.0	-1000.0	-0.085	-1000.0
amb2 Integrin signaling	7.0	579.0	82.0	-0.165	0.034	1000.0	-1000.0	-0.029	-1000.0
Reelin signaling pathway	7.0	436.0	56.0	-0.118	0.062	1000.0	-1000.0	-0.033	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	7.0	491.0	68.0	-0.248	0.063	1000.0	-1000.0	-0.076	-1000.0
E-cadherin signaling in keratinocytes	7.0	305.0	43.0	-0.08	0.029	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	6.0	430.0	65.0	-0.143	0.039	1000.0	-1000.0	-0.053	-1000.0
Caspase cascade in apoptosis	6.0	452.0	74.0	-0.117	0.067	1000.0	-1000.0	-0.039	-1000.0
IL12-mediated signaling events	6.0	608.0	87.0	-0.227	0.029	1000.0	-1000.0	-0.066	-1000.0
Noncanonical Wnt signaling pathway	6.0	166.0	26.0	-0.072	0.027	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	6.0	731.0	105.0	-0.146	0.074	1000.0	-1000.0	-0.044	-1000.0
HIF-1-alpha transcription factor network	6.0	491.0	76.0	-0.217	0.041	1000.0	-1000.0	-0.082	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	524.0	85.0	-0.124	0.093	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	6.0	564.0	81.0	-0.123	0.054	1000.0	-1000.0	-0.058	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	631.0	97.0	-0.093	0.042	1000.0	-1000.0	-0.048	-1000.0
EGFR-dependent Endothelin signaling events	6.0	141.0	21.0	-0.043	0.039	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	6.0	464.0	67.0	-0.104	0.074	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	293.0	54.0	-0.083	0.034	1000.0	-1000.0	-0.049	-1000.0
Arf6 signaling events	5.0	333.0	62.0	-0.13	0.041	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	232.0	46.0	-0.223	0.026	1000.0	-1000.0	-0.095	-1000.0
HIF-2-alpha transcription factor network	5.0	219.0	43.0	-0.103	0.043	1000.0	-1000.0	-0.044	-1000.0
FAS signaling pathway (CD95)	5.0	254.0	47.0	-0.219	0.039	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	5.0	492.0	85.0	-0.06	0.05	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	5.0	131.0	26.0	-0.063	0.028	1000.0	-1000.0	-0.004	-1000.0
Glypican 2 network	5.0	22.0	4.0	0.002	0.01	1000.0	-1000.0	0.011	-1000.0
Nongenotropic Androgen signaling	5.0	291.0	52.0	-0.132	0.078	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	732.0	125.0	-0.065	0.047	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	450.0	76.0	-0.071	0.041	1000.0	-1000.0	-0.059	-1000.0
BCR signaling pathway	5.0	496.0	99.0	-0.113	0.043	1000.0	-1000.0	-0.049	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	479.0	88.0	-0.129	0.038	1000.0	-1000.0	-0.062	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	697.0	120.0	-0.11	0.1	1000.0	-1000.0	-0.045	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.004	0.004	1000.0	-1000.0	-0.009	-1000.0
ErbB4 signaling events	4.0	283.0	69.0	-0.107	0.095	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	4.0	234.0	57.0	-0.025	0.05	1000.0	-1000.0	-0.035	-1000.0
Osteopontin-mediated events	4.0	164.0	38.0	-0.069	0.031	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PTP1B	4.0	343.0	76.0	-0.071	0.045	1000.0	-1000.0	-0.033	-1000.0
Glypican 1 network	4.0	212.0	48.0	-0.122	0.038	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	4.0	153.0	36.0	-0.09	0.026	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	4.0	230.0	51.0	-0.108	0.059	1000.0	-1000.0	-0.054	-1000.0
IL6-mediated signaling events	4.0	368.0	75.0	-0.14	0.045	1000.0	-1000.0	-0.041	-1000.0
IGF1 pathway	4.0	281.0	57.0	-0.033	0.05	1000.0	-1000.0	-0.036	-1000.0
Plasma membrane estrogen receptor signaling	4.0	354.0	86.0	-0.085	0.058	1000.0	-1000.0	-0.049	-1000.0
S1P3 pathway	4.0	187.0	42.0	-0.103	0.035	1000.0	-1000.0	-0.023	-1000.0
Visual signal transduction: Rods	4.0	259.0	52.0	-0.086	0.027	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	3.0	244.0	76.0	-0.091	0.046	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Cones	3.0	128.0	38.0	-0.043	0.028	1000.0	-1000.0	-0.009	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	53.0	17.0	-0.04	0.031	1000.0	-1000.0	-0.026	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	229.0	61.0	-0.159	0.073	1000.0	-1000.0	-0.038	-1000.0
IFN-gamma pathway	3.0	251.0	68.0	-0.098	0.036	1000.0	-1000.0	-0.053	-1000.0
Nectin adhesion pathway	3.0	240.0	63.0	-0.06	0.047	1000.0	-1000.0	-0.045	-1000.0
ceramide signaling pathway	3.0	159.0	49.0	-0.0	0.039	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	47.0	15.0	-0.014	0.028	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	3.0	202.0	58.0	-0.065	0.054	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	3.0	194.0	51.0	-0.159	0.046	1000.0	-1000.0	-0.04	-1000.0
LPA receptor mediated events	3.0	383.0	102.0	-0.089	0.038	1000.0	-1000.0	-0.083	-1000.0
IL2 signaling events mediated by STAT5	3.0	68.0	22.0	-0.048	0.029	1000.0	-1000.0	-0.04	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	100.0	33.0	-0.068	0.059	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	3.0	199.0	51.0	-0.091	0.041	1000.0	-1000.0	-0.108	-1000.0
Regulation of Androgen receptor activity	3.0	267.0	70.0	-0.18	0.04	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	65.0	17.0	-0.028	0.045	1000.0	-1000.0	-0.018	-1000.0
LPA4-mediated signaling events	2.0	24.0	12.0	-0.047	0.006	1000.0	-1000.0	-0.021	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	374.0	136.0	-0.306	0.181	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	56.0	28.0	-0.013	0.044	1000.0	-1000.0	-0.022	-1000.0
PLK2 and PLK4 events	2.0	7.0	3.0	-0.0	-1000.0	1000.0	-1000.0	-0.012	-1000.0
Syndecan-2-mediated signaling events	2.0	202.0	69.0	-0.054	0.042	1000.0	-1000.0	-0.048	-1000.0
Cellular roles of Anthrax toxin	2.0	100.0	39.0	-0.039	0.027	1000.0	-1000.0	-0.022	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	165.0	65.0	-0.181	0.065	1000.0	-1000.0	-0.052	-1000.0
PLK1 signaling events	2.0	215.0	85.0	-0.024	0.047	1000.0	-1000.0	-0.03	-1000.0
PDGFR-alpha signaling pathway	2.0	118.0	44.0	-0.144	0.051	1000.0	-1000.0	-0.035	-1000.0
Ceramide signaling pathway	2.0	226.0	76.0	-0.054	0.063	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class III	2.0	80.0	40.0	-0.057	0.05	1000.0	-1000.0	-0.015	-1000.0
TRAIL signaling pathway	2.0	120.0	48.0	-0.004	0.059	1000.0	-1000.0	-0.033	-1000.0
IL1-mediated signaling events	2.0	185.0	62.0	-0.031	0.06	1000.0	-1000.0	-0.039	-1000.0
S1P5 pathway	2.0	49.0	17.0	-0.015	0.027	1000.0	-1000.0	-0.013	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	121.0	52.0	-0.066	0.079	1000.0	-1000.0	-0.044	-1000.0
FoxO family signaling	2.0	161.0	64.0	-0.075	0.053	1000.0	-1000.0	-0.052	-1000.0
Syndecan-3-mediated signaling events	2.0	103.0	35.0	-0.039	0.073	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	2.0	171.0	58.0	-0.062	0.052	1000.0	-1000.0	-0.043	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	107.0	45.0	-0.024	0.06	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	2.0	149.0	54.0	-0.065	0.058	1000.0	-1000.0	-0.049	-1000.0
TCGA08_rtk_signaling	2.0	66.0	26.0	-0.029	0.057	1000.0	-1000.0	-0.009	-1000.0
Regulation of Telomerase	2.0	254.0	102.0	-0.144	0.066	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	2.0	146.0	56.0	-0.037	0.036	1000.0	-1000.0	-0.051	-1000.0
PDGFR-beta signaling pathway	2.0	234.0	97.0	-0.04	0.063	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by PRL	2.0	71.0	34.0	-0.042	0.038	1000.0	-1000.0	-0.041	-1000.0
S1P4 pathway	2.0	68.0	25.0	-0.025	0.037	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	216.0	78.0	-0.029	0.042	1000.0	-1000.0	-0.044	-1000.0
Aurora B signaling	2.0	186.0	67.0	-0.08	0.034	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	0.013	0.041	1000.0	-1000.0	0.007	-1000.0
Aurora A signaling	1.0	83.0	60.0	-0.056	0.064	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	1.0	73.0	43.0	-0.037	0.043	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	1.0	10.0	7.0	-0.0	0.034	1000.0	-1000.0	-0.019	-1000.0
EPO signaling pathway	1.0	71.0	55.0	-0.001	0.064	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	1.0	55.0	32.0	-0.075	0.05	1000.0	-1000.0	-0.026	-1000.0
mTOR signaling pathway	1.0	99.0	53.0	-0.033	0.042	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	84.0	68.0	-0.075	0.052	1000.0	-1000.0	-0.028	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	54.0	37.0	-0.013	0.066	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	157.0	83.0	-0.075	0.053	1000.0	-1000.0	-0.036	-1000.0
TCGA08_p53	1.0	13.0	7.0	-0.018	0.026	1000.0	-1000.0	-0.006	-1000.0
Atypical NF-kappaB pathway	1.0	48.0	31.0	-0.016	0.04	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	1.0	93.0	73.0	-0.065	0.053	1000.0	-1000.0	-0.038	-1000.0
Insulin Pathway	1.0	138.0	74.0	-0.072	0.067	1000.0	-1000.0	-0.038	-1000.0
Rapid glucocorticoid signaling	1.0	35.0	20.0	-0.013	0.035	1000.0	-1000.0	-0.003	-1000.0
p38 MAPK signaling pathway	1.0	82.0	44.0	-0.077	0.047	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	-0.024	0.053	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	0.0	27.0	39.0	-0.0	0.058	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class II	0.0	43.0	75.0	-0.038	0.073	1000.0	-1000.0	-0.03	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.008	0.05	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	95.0	104.0	-0.05	0.055	1000.0	-1000.0	-0.03	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.056	0.059	1000.0	-1000.0	-0.034	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	0.0	69.0	71.0	-0.046	0.048	1000.0	-1000.0	-0.028	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.001	0.056	1000.0	-1000.0	-0.024	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Total	529	34279	7203	-11.8984348422	-993.098266751	131000	-131000	-4.80094849467	-131000