rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(5), NR1H3(5), NR1H4(3), RXRA(2) 3418440 15 15 15 0 2 2 4 3 4 0 0.0133 0.000407 0.250 2 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(2), FPGS(1), GCH1(1), SPR(2) 3429581 10 10 10 1 3 3 2 1 1 0 0.0914 0.0318 1.000 3 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(3), CREBBP(11), DFFB(1), GZMA(2), PRF1(1) 6668804 18 18 18 2 2 1 3 4 8 0 0.264 0.0351 1.000 4 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(2), GRIA2(6) 2208351 8 8 8 1 0 0 1 5 2 0 0.583 0.0362 1.000 5 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), HTR2C(6), PLCB1(6), TUB(1) 4745469 14 13 14 1 2 4 6 2 0 0 0.0632 0.0458 1.000 6 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREBBP(11), EP300(2), NCOA3(5), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RARA(1), RXRA(2) 13212238 30 29 30 2 2 2 7 8 11 0 0.0406 0.0522 1.000 7 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), PRKCE(1), SOD1(1) 4480716 17 16 17 3 3 0 4 6 4 0 0.280 0.0570 1.000 8 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(11), DAXX(3), PAX3(5), RARA(1), SP100(7), TNF(1), TNFRSF1A(2) 10230269 30 29 30 4 3 2 10 5 10 0 0.119 0.0584 1.000 9 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3) 6899991 19 18 19 2 3 5 7 2 2 0 0.0454 0.0588 1.000 10 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 781618 3 3 3 1 0 0 2 0 1 0 0.790 0.0611 1.000 11 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(1) 1384022 5 5 5 1 0 0 1 4 0 0 0.598 0.0641 1.000 12 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 IL8(3), SLPI(1) 1051627 4 4 4 0 0 1 1 1 1 0 0.348 0.0683 1.000 13 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CSF1(1), LDLR(5), LPL(1) 3569081 10 9 10 1 1 3 4 1 1 0 0.183 0.0718 1.000 14 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR2(2), BDKRB2(4), KNG1(1), NOS3(2), REN(2) 5606147 13 13 13 1 5 2 2 4 0 0 0.0511 0.0736 1.000 15 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(1), FUT3(2), FUT6(1), ST3GAL3(3) 2630898 8 8 8 0 4 1 2 0 1 0 0.0388 0.0755 1.000 16 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT3(2), ST3GAL3(3) 4630480 11 11 11 1 4 2 3 0 2 0 0.0981 0.0764 1.000 17 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(2), CD3G(1), HLA-A(1), ICAM1(1), ITGAL(6), ITGB2(2), PRF1(1) 5325651 16 14 15 2 2 3 4 4 3 0 0.106 0.0909 1.000 18 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(4), AASDHPPT(1), AASS(3), KARS(2) 4691233 10 10 10 1 0 0 3 5 2 0 0.254 0.107 1.000 19 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR6(4), NFS1(1), THTPA(1), TPK1(2) 4211866 10 9 10 1 3 2 0 3 2 0 0.183 0.116 1.000 20 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(8), CYP11B2(4), CYP21A2(2), HSD3B1(2), HSD3B2(1) 5765378 21 21 20 4 4 0 9 5 3 0 0.456 0.135 1.000 21 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(8), CYP11B2(4), CYP21A2(2), HSD3B1(2), HSD3B2(1) 5765378 21 21 20 4 4 0 9 5 3 0 0.456 0.135 1.000 22 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(3), HSD3B7(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 3099771 8 8 8 0 2 0 4 1 1 0 0.124 0.138 1.000 23 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(1), ESR2(2), PDE1A(1), PDE1B(1), PLCB1(6), PLCB2(3), TRH(1) 6966866 15 15 15 0 0 4 8 3 0 0 0.0162 0.140 1.000 24 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(4), XYLT2(1) 3814791 10 10 10 1 4 1 3 1 1 0 0.112 0.142 1.000 25 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(4), XYLT2(1) 3814791 10 10 10 1 4 1 3 1 1 0 0.112 0.142 1.000 26 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3E(2), CD3G(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3) 7319026 18 17 18 2 2 5 7 2 2 0 0.0619 0.146 1.000 27 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(1), B4GALT5(3), FUT8(1), ST3GAL2(2), ST3GAL3(3) 4992058 11 11 11 0 4 1 2 3 1 0 0.0606 0.156 1.000 28 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(1), HAO1(3), HAO2(2), HYI(1), MDH1(1), MDH2(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 8551441 17 17 16 0 6 2 4 3 2 0 0.00573 0.165 1.000 29 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CDKN1B(1), CUL1(2), SKP2(2), TFDP1(3), UBE2M(1) 4386084 9 9 9 1 2 3 1 1 2 0 0.187 0.174 1.000 30 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(1), GLUD2(3) 2738215 7 6 7 1 0 1 3 2 1 0 0.582 0.181 1.000 31 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(1), OXCT1(2) 2287159 6 5 6 1 0 2 2 2 0 0 0.489 0.193 1.000 32 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 11 DNM1(1), GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), GPHN(2), SRC(1) 7298062 19 19 19 3 4 1 4 6 4 0 0.194 0.194 1.000 33 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PDXP(1), PSAT1(1) 3154268 7 7 7 1 0 1 2 3 1 0 0.472 0.201 1.000 34 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(1), HAO1(3), HAO2(2), HYI(1), MDH1(1), MDH2(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 8973148 17 17 16 0 6 2 4 3 2 0 0.00546 0.220 1.000 35 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(3), KARS(2) 3203801 6 6 6 1 0 0 1 4 1 0 0.484 0.223 1.000 36 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(1), CD3E(2), CD3G(1), CD8A(1), CSF3(1), IL8(3), KITLG(1) 4182671 13 12 13 3 1 3 5 1 3 0 0.390 0.224 1.000 37 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 5 DAG1(3), GNAQ(1), ITPKB(4) 3407204 8 7 8 1 2 2 3 0 1 0 0.264 0.225 1.000 38 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 GLB1(1), GUSB(2), HEXA(3), HEXB(1), IDS(2), LCT(9), NAGLU(2) 8723739 20 20 20 2 1 3 10 2 4 0 0.0847 0.228 1.000 39 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), ADRB2(1), CFTR(2), GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 7835961 15 15 14 1 4 0 3 3 5 0 0.109 0.231 1.000 40 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(2) 7266699 15 15 15 2 2 8 3 2 0 0 0.105 0.261 1.000 41 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(3), F2R(3), F3(1), F5(8), F7(1), FGA(3), FGB(2), PROS1(1), SERPINC1(2) 10400442 25 24 25 3 4 3 11 6 1 0 0.112 0.270 1.000 42 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 6 CUL1(2), FBXW7(5), TFDP1(3) 4156772 10 10 10 2 3 1 3 1 2 0 0.450 0.279 1.000 43 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), FUT1(1), FUT9(1), HEXA(3), HEXB(1), ST3GAL2(2), ST8SIA1(3) 6595122 12 12 12 1 2 2 3 5 0 0 0.112 0.286 1.000 44 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL2(2), ST3GAL5(1), ST8SIA1(3) 3475188 7 7 7 0 1 1 2 2 1 0 0.166 0.288 1.000 45 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(5), HLA-DRA(1), HLA-DRB1(1), IL5RA(1) 3640692 8 7 8 1 2 1 2 2 1 0 0.357 0.302 1.000 46 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(2), NFKBIA(2), PLCB1(6), PRKCA(2), RELA(1) 5499775 14 12 14 2 2 3 5 1 3 0 0.283 0.314 1.000 47 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(2) 2724801 6 5 6 0 0 1 1 1 3 0 0.220 0.314 1.000 48 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(6), ERBB3(5), NRG1(4) 6936555 15 15 15 2 0 4 7 3 1 0 0.250 0.319 1.000 49 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT9(1), HEXA(3), HEXB(1), ST3GAL2(2), ST8SIA1(3) 6169646 11 11 11 1 2 1 3 5 0 0 0.168 0.321 1.000 50 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(2), GAD1(1), GAD2(2), GGT1(1) 3710398 7 7 7 1 1 2 0 2 2 0 0.339 0.324 1.000 51 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(1), FUT1(1), FUT9(1), GCNT2(2), ST8SIA1(3) 3824717 9 9 9 2 2 2 1 2 2 0 0.365 0.331 1.000 52 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), UGDH(1), UXS1(2) 2655592 5 5 4 0 0 0 3 1 1 0 0.387 0.334 1.000 53 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 1212450 3 3 3 1 0 0 2 1 0 0 0.814 0.343 1.000 54 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(3), ACADS(1), ACAT1(3), HADHA(1) 3433184 8 7 8 2 1 2 2 1 2 0 0.589 0.346 1.000 55 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(2) 1775458 3 3 3 0 0 1 0 1 1 0 0.496 0.346 1.000 56 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(1), CREBBP(11), EP300(2), FADD(1), HDAC3(2), IKBKB(2), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF6(2) 14509449 29 28 29 3 3 5 6 5 10 0 0.0706 0.356 1.000 57 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(8), ATR(3), BRCA2(13), CHEK2(3), FANCA(5), FANCC(1), FANCD2(1), FANCE(1), FANCF(2), FANCG(1), HUS1(1), MRE11A(1), RAD17(1), RAD50(1), RAD51(1) 26304766 43 41 43 2 4 4 8 11 16 0 0.00750 0.369 1.000 58 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 27 ADRA1A(1), ADRB2(1), CHRM2(5), CHRM3(5), CHRM5(2), DRD1(2), DRD2(2), DRD3(1), HRH1(1), HRH2(1), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1) 14760973 49 45 49 8 10 5 22 11 1 0 0.0120 0.376 1.000 59 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3), AOC2(4), AOC3(2) 3865151 9 9 9 2 1 0 1 3 4 0 0.619 0.385 1.000 60 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(1), APOBEC3A(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 4897834 8 8 8 0 3 3 2 0 0 0 0.0553 0.390 1.000 61 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3), SPCS3(1) 2049575 4 4 4 0 0 1 2 1 0 0 0.333 0.415 1.000 62 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(4), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(2), PRKAR2B(1) 6728671 11 11 11 0 2 1 3 2 3 0 0.0408 0.416 1.000 63 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), DDC(2), EPX(2), GOT1(1), HPD(3), LPO(1), MAOA(2), MAOB(1), MPO(2), PRDX5(1), TAT(2), TPO(6) 14140460 35 33 35 4 4 3 11 10 7 0 0.0266 0.424 1.000 64 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(2), CD3G(1) 1884959 3 3 3 1 0 0 2 0 1 0 0.760 0.427 1.000 65 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), CAT(1), EPX(2), LPO(1), MPO(2), PRDX5(1), SHMT1(2), SHMT2(1), TPO(6) 7402507 18 18 18 3 4 1 7 4 2 0 0.147 0.437 1.000 66 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3) 2056105 3 3 3 0 1 0 1 1 0 0 0.471 0.443 1.000 67 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 GLB1(1), GUSB(2), HEXA(3), HEXB(1), HPSE(1), HPSE2(2), IDS(2), LCT(9), NAGLU(2), SPAM1(6) 12600413 29 28 29 4 2 5 11 7 4 0 0.0757 0.453 1.000 68 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(1), FADD(1), IKBKB(2), IRAK1(3), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TLR4(5), TNF(1), TNFAIP3(3), TNFRSF1A(2), TRAF6(2) 15406136 31 28 31 3 5 9 7 7 3 0 0.0169 0.466 1.000 69 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(8), ATR(3), CHEK2(3) 10438589 14 14 14 0 3 1 3 4 3 0 0.0512 0.485 1.000 70 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(1), B3GNT2(2), B4GALT2(1), CHST2(2), FUT8(1), ST3GAL2(2), ST3GAL3(3) 7184220 12 12 12 1 5 2 2 2 1 0 0.103 0.489 1.000 71 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BNIP1(1), GOSR2(1), SNAP23(1), STX10(1), STX11(1), STX12(1), STX16(3), STX3(2), STX5(3), STX6(1), TSNARE1(2), VTI1A(1), VTI1B(1) 10370292 19 19 19 2 3 2 4 5 5 0 0.0626 0.504 1.000 72 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(2), NRG2(3), NRG3(1), PRKCA(2) 5956645 9 9 9 1 2 1 1 4 1 0 0.241 0.508 1.000 73 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(1), DFFB(1), HMGB1(1), TOP2A(8), TOP2B(1) 6200296 12 12 12 2 0 1 5 1 5 0 0.754 0.517 1.000 74 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), UGDH(1), UXS1(2) 3383213 5 5 4 0 0 0 3 1 1 0 0.392 0.517 1.000 75 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD1(2), DRD2(2), GRM1(4), PLCB1(6), PPP2CA(2), PPP3CA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 10151605 24 22 24 4 2 2 12 5 3 0 0.198 0.547 1.000 76 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(3), IL8(3), NFKB1(2), RELA(1), SOD1(1), TNF(1), XDH(2) 6763675 15 15 15 3 1 3 8 1 2 0 0.426 0.550 1.000 77 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3) 9774956 21 20 21 3 2 5 6 5 3 0 0.171 0.555 1.000 78 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1), SHMT1(2), SHMT2(1) 2556703 4 4 4 0 1 1 0 2 0 0 0.265 0.579 1.000 79 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(2), LPO(1), MPO(2), SHMT1(2), SHMT2(1), TPO(6) 7412231 17 17 17 3 4 0 7 4 2 0 0.204 0.587 1.000 80 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(1), CHST12(1), PAPSS1(1), SULT1A1(2), SULT1E1(1), SULT2A1(1), SULT2B1(1), SUOX(1) 5857165 9 9 9 1 2 0 2 4 1 0 0.268 0.591 1.000 81 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(1), HLA-DRB1(1) 1619865 2 2 2 0 0 1 0 0 1 0 0.574 0.600 1.000 82 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(2), KERA(1) 2424076 3 3 3 1 0 0 1 2 0 0 0.845 0.602 1.000 83 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), MIOX(1), UGDH(1) 5325654 10 10 10 2 0 4 1 3 2 0 0.429 0.602 1.000 84 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(5), MBTPS1(2), MBTPS2(1), SCAP(2), SREBF1(1), SREBF2(1) 6664447 12 12 12 2 3 1 4 3 1 0 0.310 0.606 1.000 85 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), EHHADH(2), HADHA(1), SDS(1) 3142413 6 6 6 2 0 0 4 1 1 0 0.846 0.608 1.000 86 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 20 APC(11), AXIN1(1), BTRC(1), CREBBP(11), CSNK1D(1), CSNK2A1(2), CTNNB1(2), FZD1(1), HDAC1(1), MAP3K7(2), NLK(1), PPARD(3), PPP2CA(2), TLE1(1), WIF1(2) 17673663 42 38 42 6 1 6 13 12 10 0 0.0798 0.610 1.000 87 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(1), B4GALT2(1), FUT1(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), ST3GAL6(1), ST8SIA1(3) 9022710 18 18 18 3 5 3 2 4 4 0 0.174 0.610 1.000 88 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CREBBP(11), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTPRC(3), ZAP70(1) 14225370 33 33 32 5 4 3 7 7 12 0 0.147 0.611 1.000 89 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CREBBP(11), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTPRC(3), ZAP70(1) 14225370 33 33 32 5 4 3 7 7 12 0 0.147 0.611 1.000 90 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1R(4), TNF(1) 3723027 6 6 6 1 1 1 3 0 1 0 0.522 0.614 1.000 91 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(3), PPP2CA(2), PRKAA2(2), PRKAB2(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 9419891 19 19 18 3 4 1 2 6 6 0 0.211 0.614 1.000 92 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT6(2), GALNT8(1), ST3GAL2(2), WBSCR17(1) 9501967 13 13 13 1 1 3 3 5 1 0 0.0966 0.621 1.000 93 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB4A(1), RAB9A(2) 2866716 4 4 4 1 2 1 1 0 0 0 0.561 0.627 1.000 94 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(1), FUCA2(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), MANBA(1), NEU1(1), NEU2(1), NEU3(1) 10333449 20 20 20 3 2 4 8 3 3 0 0.125 0.632 1.000 95 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 14 B3GAT1(2), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(1), CHST12(1), CHST14(1), CHSY1(1), DSE(2), UST(2), XYLT1(4), XYLT2(1) 8195377 18 16 18 2 6 1 8 0 3 0 0.0906 0.633 1.000 96 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(11), EP300(2), LPL(1), NCOA1(2), NCOA2(2), RXRA(2) 12010963 20 20 20 3 0 2 3 7 8 0 0.332 0.633 1.000 97 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2B(2), ADORA3(2), P2RY1(1), P2RY2(2), P2RY6(1) 3685423 8 8 8 2 2 1 2 3 0 0 0.431 0.638 1.000 98 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(1), SULT1E1(1), SULT2A1(1), SUOX(1) 4107107 5 5 5 0 2 0 0 2 1 0 0.240 0.647 1.000 99 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1), ALDOB(1), ALDOC(1) 2530664 3 3 3 1 2 1 0 0 0 0 0.647 0.651 1.000 100 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(1), CDKN1B(1), E2F2(2), NXT1(1), PRB1(1) 4433274 6 6 6 1 2 2 0 2 0 0 0.373 0.655 1.000 101 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(1) 6078262 10 10 10 2 0 2 4 1 3 0 0.495 0.671 1.000 102 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(1), BDH1(1), HMGCS2(1), OXCT1(2) 4770368 8 7 8 2 0 2 3 2 1 0 0.526 0.681 1.000 103 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(2), PRKCA(2), PTK2B(3) 4505585 9 9 9 2 3 0 4 1 1 0 0.532 0.681 1.000 104 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2B5(7), EIF2S1(1), EIF2S2(1) 7464131 12 12 12 2 3 2 3 2 2 0 0.317 0.685 1.000 105 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), ST3GAL2(2), ST3GAL5(1), ST6GALNAC3(2), ST8SIA1(3), ST8SIA5(1) 10701995 25 23 25 4 1 3 12 5 4 0 0.162 0.687 1.000 106 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BIRC3(2), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TRAF2(1) 5141250 9 9 9 2 0 3 4 1 1 0 0.505 0.698 1.000 107 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(1), ESR1(1), GREB1(4), MTA1(2), MTA3(2), TUBA8(1) 5824861 11 11 11 2 2 3 5 1 0 0 0.236 0.700 1.000 108 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), NR3C1(2), RXRA(2), TNF(1) 3724079 6 6 6 2 0 1 2 2 1 0 0.724 0.713 1.000 109 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), WASL(1) 5354026 7 7 7 1 0 3 3 1 0 0 0.423 0.725 1.000 110 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(4), FARSB(1), GOT1(1), PAH(3), TAT(2), YARS(1), YARS2(1) 5887981 15 15 15 4 1 1 4 5 4 0 0.584 0.726 1.000 111 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(5), HLA-DRA(1), HLA-DRB1(1) 2015723 7 6 7 3 1 1 2 2 1 0 0.867 0.729 1.000 112 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), BHMT(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(3), MARS(3), MARS2(1), MTFMT(2), TAT(2) 13299128 21 21 21 2 1 5 9 6 0 0 0.0648 0.736 1.000 113 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), ADRB2(1), GNAS(3), PLCE1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 8814852 14 14 13 2 4 0 1 4 5 0 0.249 0.742 1.000 114 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(3), PRKACA(1) 3867796 7 7 6 2 3 0 1 1 2 0 0.596 0.749 1.000 115 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(1), FADS2(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1) 6609043 9 9 9 1 0 1 4 2 2 0 0.347 0.752 1.000 116 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(1), DHRS7(2), HSD3B7(1), PON3(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 5491530 9 9 9 2 1 2 4 0 2 0 0.425 0.762 1.000 117 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 1373509 1 1 1 1 0 0 0 1 0 0 0.950 0.778 1.000 118 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), ACO2(1), FH(1), IDH1(1), MDH1(1), MDH2(2) 5992322 7 7 7 0 1 1 2 2 1 0 0.124 0.781 1.000 119 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(3), IL13(1), MAPK14(2), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 6596349 16 16 16 4 4 1 3 6 2 0 0.367 0.781 1.000 120 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP68(3), SRP72(2), SRPR(1) 4948922 8 8 8 2 0 2 4 0 2 0 0.767 0.782 1.000 121 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(2), CHUK(1), IKBKB(2), MAP3K1(2), MAP3K5(5), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(1), TNFRSF9(1), TRAF2(1) 12771617 22 21 22 3 4 7 2 5 4 0 0.111 0.787 1.000 122 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(1), SHMT1(2), SHMT2(1) 3444430 4 4 4 1 1 1 0 2 0 0 0.612 0.789 1.000 123 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(2), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1) 11119784 19 19 19 3 1 5 6 3 4 0 0.129 0.792 1.000 124 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(2), CDKN1A(1), NEK1(4) 4779889 8 8 8 2 2 0 3 2 1 0 0.746 0.795 1.000 125 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(1), HK2(2), HK3(4), IMPA2(1), ISYNA1(1) 7200409 10 10 10 1 4 2 4 0 0 0 0.116 0.798 1.000 126 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2) 2484854 2 2 2 0 0 1 0 1 0 0 0.498 0.802 1.000 127 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(1), FUCA2(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), MAN2B1(3), MAN2B2(2), MANBA(1), NEU1(1), NEU2(1), NEU3(1) 12684238 25 24 25 4 2 4 10 6 3 0 0.119 0.812 1.000 128 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 27 CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL8(3), LTA(1), TGFB2(1), TNF(1) 8607280 16 15 16 3 1 3 3 4 5 0 0.310 0.822 1.000 129 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD8A(1), CSF1(1), CSF3(1), IL8(3) 3985938 6 6 6 2 2 1 0 1 2 0 0.587 0.823 1.000 130 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL16(4), IL8(3), LTA(1), TNF(1) 6609887 15 14 15 4 1 2 4 5 3 0 0.569 0.824 1.000 131 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(1), CREBBP(11), DUSP1(1), EP300(2), IKBKB(2), IL8(3), MAP2K6(1), MAP3K14(1), MAP3K7(2), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(3), TLR2(1), TNF(1) 19085636 40 36 40 5 5 7 9 10 9 0 0.0591 0.828 1.000 132 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(1), RELN(10), VLDLR(1) 9489436 14 13 14 2 1 4 5 3 1 0 0.170 0.832 1.000 133 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 AKR1B1(3), B4GALT2(1), G6PC(1), G6PC2(1), GAA(1), GALE(1), GALK2(1), GALT(1), GCK(1), GLB1(1), HK1(1), HK2(2), HK3(4), HSD3B7(1), LCT(9), MGAM(6), PFKM(1), PFKP(2), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 23401941 42 40 42 4 9 5 16 7 5 0 0.00450 0.837 1.000 134 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 16 ABL1(1), ATM(8), CDKN1A(1), CHEK2(3), MAPK8(1), MRE11A(1), NFKB1(2), NFKBIA(2), RAD50(1), RAD51(1), RELA(1) 16005114 22 21 22 2 5 3 5 2 7 0 0.104 0.837 1.000 135 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(1), HK2(2), HK3(4) 6635587 8 8 8 1 4 2 2 0 0 0 0.168 0.851 1.000 136 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 7 CCNA1(2), CUL1(2), SKP2(2), TFDP1(3) 4296002 9 9 9 3 1 3 2 1 2 0 0.663 0.853 1.000 137 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(2), GAD1(1), HDC(2) 3422614 5 5 5 2 1 1 1 2 0 0 0.752 0.856 1.000 138 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(2), ATM(8), CDKN1A(1) 10119919 11 11 11 0 2 2 2 3 2 0 0.0548 0.856 1.000 139 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(1), EIF2S1(1), EIF2S2(1), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1) 5838716 10 9 10 2 1 2 3 2 2 0 0.549 0.859 1.000 140 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(1) 3194870 3 3 3 1 0 0 2 1 0 0 0.863 0.860 1.000 141 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(3), ITGAL(6), ITGB2(2), PECAM1(2), SELE(2) 7821500 16 15 16 4 2 4 5 3 2 0 0.380 0.862 1.000 142 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(1), COQ6(1) 2689343 2 2 2 1 0 0 1 0 1 0 0.886 0.867 1.000 143 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(1), CDC25B(2), MYT1(1) 9137482 12 12 12 2 1 1 5 2 3 0 0.522 0.868 1.000 144 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), FH(1), MDH1(1), OGDH(3), SDHA(1) 6227354 7 7 7 0 1 2 3 0 1 0 0.138 0.870 1.000 145 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(1), SQLE(1) 2830969 2 2 2 1 0 0 0 2 0 0 0.890 0.870 1.000 146 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(1), MPO(2), TPO(6) 5373334 11 11 11 3 2 0 6 2 1 0 0.531 0.879 1.000 147 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 2087463 1 1 1 1 0 0 0 1 0 0 0.957 0.888 1.000 148 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2) 10171402 13 13 12 2 3 1 2 6 1 0 0.269 0.888 1.000 149 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2) 10171402 13 13 12 2 3 1 2 6 1 0 0.269 0.888 1.000 150 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2) 10171402 13 13 12 2 3 1 2 6 1 0 0.269 0.888 1.000 151 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), GART(3), MTFMT(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1), SHMT1(2), SHMT2(1) 12276420 22 22 21 4 4 2 9 3 4 0 0.328 0.893 1.000 152 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2) 5812232 11 11 10 3 2 0 1 3 5 0 0.600 0.894 1.000 153 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(1), APAF1(2), CASP9(2), DAXX(3), TNF(1) 7242669 9 9 9 2 0 2 3 2 2 0 0.464 0.899 1.000 154 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1B(1), BMPR2(3) 4130282 6 6 6 2 0 1 2 3 0 0 0.667 0.901 1.000 155 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(6), CYP7A1(1), HMGCR(2), LDLR(5), LIPC(1), LPL(1), LRP1(12) 16439596 28 27 28 4 7 3 8 5 5 0 0.0404 0.903 1.000 156 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(3), MARS(3), MARS2(1) 11266428 16 16 16 2 1 4 6 5 0 0 0.155 0.903 1.000 157 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 15 ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), ALOX5AP(1), GGT1(1), LTA4H(1), PLA2G6(1), PTGDS(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2) 8803131 18 17 18 4 2 7 8 0 1 0 0.110 0.903 1.000 158 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(1), HSD17B4(1), MECR(3), PPT1(1) 5613059 7 7 7 2 2 0 3 2 0 0 0.601 0.908 1.000 159 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(1), FURIN(1) 3115895 2 2 2 1 0 1 0 1 0 0 0.848 0.910 1.000 160 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACOX1(1), ACOX3(1), ELOVL2(2), ELOVL6(1), FADS2(2), HADHA(1), PECR(1) 7116002 9 9 9 2 2 1 2 2 2 0 0.487 0.910 1.000 161 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(1), ACO2(1), ACSS1(1), FH(1), IDH1(1), MDH1(1), MDH2(2) 8947929 10 10 10 0 1 1 4 3 1 0 0.0635 0.911 1.000 162 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(1), EHHADH(2), GCDH(1), HADHA(1), SDS(1) 5111812 9 7 9 3 0 3 4 1 1 0 0.743 0.913 1.000 163 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1) 2175891 1 1 1 2 0 0 0 0 1 0 0.972 0.913 1.000 164 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GNPDA2(1), HEXA(3), HEXB(1), HK1(1), HK2(2), HK3(4), RENBP(2), UAP1(2) 10945056 18 16 18 3 4 2 5 5 2 0 0.215 0.916 1.000 165 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(5), ATM(8), CDKN1A(1), CPB2(1), CSNK1D(1), MAPK8(1), NFKBIB(1), NQO1(1) 12698426 19 19 19 3 3 2 7 3 4 0 0.272 0.918 1.000 166 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2) 10602386 13 13 12 2 3 1 2 6 1 0 0.267 0.919 1.000 167 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), SHMT1(2), SHMT2(1) 12030532 20 20 19 4 4 2 7 3 4 0 0.383 0.924 1.000 168 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(1), ANKRD1(2), NR4A3(1), WDR1(2) 6888360 6 6 6 0 2 0 1 3 0 0 0.193 0.924 1.000 169 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(8), CDC25A(1), CDC25B(2), MYT1(1) 9994129 12 12 12 2 1 1 5 2 3 0 0.516 0.928 1.000 170 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(1), IFNA1(2), IFNB1(1), IKBKB(2), IRAK1(3), IRAK2(1), IRAK3(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(2), MAPK8(1), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TGFB2(1), TNF(1), TRAF6(2) 18859339 31 29 31 4 6 9 7 7 2 0 0.0369 0.928 1.000 171 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1) 3811874 4 3 4 2 0 1 1 1 1 0 0.874 0.930 1.000 172 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(3), CD3E(2), CD3G(1), CXCR3(3), IL12RB1(1), IL12RB2(2), JAK2(1), STAT4(2), TYK2(2) 9414409 17 16 17 4 1 3 7 3 3 0 0.407 0.930 1.000 173 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 11 CNR1(1), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGDR(1), PTGFR(3) 6419980 10 10 10 3 3 0 3 1 3 0 0.557 0.936 1.000 174 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), C9orf95(1), CD38(2), ENPP1(3), ENPP3(3), NADK(2), NADSYN1(2), NMNAT2(1), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2) 14233046 28 27 26 5 4 2 4 11 7 0 0.198 0.937 1.000 175 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), GGT1(1), MARS(3), MARS2(1), PAPSS1(1), SCLY(2) 7798658 9 8 9 0 1 2 2 3 1 0 0.0700 0.937 1.000 176 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 22 ALDOA(1), ALDOB(1), ALDOC(1), GOT1(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PGK1(1), PGK2(1), PKLR(1), RPIA(1), TKT(2), TKTL1(4), TKTL2(1) 12553609 21 21 21 4 4 4 8 4 1 0 0.196 0.939 1.000 177 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), CD38(2), ENPP1(3), ENPP3(3), NADSYN1(2), NMNAT2(1), NNMT(1), NNT(3), NT5E(2) 9749525 22 21 21 5 3 2 4 9 4 0 0.286 0.941 1.000 178 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOA(1), ALDOB(1), ALDOC(1), G6PD(5), GPI(2), PFKM(1), PFKP(2), PGD(1), PRPS1L1(2), RPIA(1), TKT(2), TKTL1(4), TKTL2(1) 14834811 24 21 24 3 4 8 9 3 0 0 0.0255 0.942 1.000 179 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(6), GLS(1), GLUD1(1), GOT1(1) 5007314 11 11 11 7 0 2 5 1 3 0 0.988 0.947 1.000 180 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(3), F2R(3), FGA(3), FGB(2), PLAU(2), PLG(4), SERPINB2(1), SERPINE1(2) 9012044 23 21 23 5 4 3 10 4 2 0 0.319 0.948 1.000 181 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(2), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), XYLB(1) 16776104 31 30 31 5 3 5 11 6 6 0 0.120 0.949 1.000 182 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(1), IFNAR2(1), IFNB1(1), STAT1(2), STAT2(2), TYK2(2) 6934106 11 11 11 3 0 2 5 4 0 0 0.604 0.950 1.000 183 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CSF3(1), FLT3(3), KITLG(1), TGFB2(1) 5457715 6 6 6 2 0 1 1 2 2 0 0.723 0.953 1.000 184 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(2), CTH(1), GOT1(1), LDHA(1), LDHB(1) 4377851 6 6 6 2 0 0 4 1 1 0 0.894 0.953 1.000 185 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), HLA-DRB1(1), IL12RB1(1), IL12RB2(2), IL18R1(2), IL2RA(1), IL4R(1) 8554209 9 9 9 2 0 4 2 1 2 0 0.410 0.953 1.000 186 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(2), CD3G(1), IL2RA(1), TGFB2(1), TGFBR1(1), TGFBR2(3), TGFBR3(4), TOB1(1), TOB2(1) 7093509 15 14 15 4 1 2 9 1 2 0 0.608 0.953 1.000 187 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(2), GOT1(1), PAH(3), TAT(2), YARS(1) 5672574 11 11 11 5 0 1 1 5 4 0 0.834 0.956 1.000 188 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(2), GLI2(10), GLI3(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), SUFU(1) 10257183 23 21 23 5 4 2 9 5 3 0 0.283 0.957 1.000 189 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(11), EP300(2), ESR1(1), PELP1(1), SRC(1) 9520544 16 15 16 4 0 1 5 4 6 0 0.680 0.960 1.000 190 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3) 4971096 3 3 3 0 1 0 2 0 0 0 0.526 0.962 1.000 191 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(2), CASP1(3), CASP8(2), CASP9(2), PRF1(1) 8541087 12 12 12 3 1 3 3 4 1 0 0.459 0.962 1.000 192 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CHUK(1), ELK1(2), FOS(1), IKBKB(2), IRAK1(3), LY96(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(2), MAPK8(1), MYD88(1), NFKB1(2), NFKBIA(2), PPARA(1), RELA(1), TIRAP(1), TLR2(1), TLR3(2), TLR4(5), TLR6(4), TLR7(2), TLR9(1), TRAF6(2) 23097995 46 41 46 7 7 11 14 11 3 0 0.0347 0.964 1.000 193 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 CPT1A(1), LEPR(5), PRKAA2(2), PRKAB2(1), PRKAG1(1), PRKAG2(1) 9799465 11 11 11 2 1 2 1 5 2 0 0.420 0.967 1.000 194 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1) 8706572 14 13 14 4 0 4 3 4 3 0 0.582 0.968 1.000 195 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FHL5(2), FSHB(1), FSHR(7), GNAS(3) 5904426 16 16 15 5 3 0 3 6 4 0 0.780 0.968 1.000 196 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(1), MPO(2), PRDX5(1), TPO(6), TYR(1) 6116412 13 13 13 4 2 1 6 3 1 0 0.583 0.969 1.000 197 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 18 CAMK2B(1), CAMK2D(2), DAG1(3), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NFAT5(4), PDE6A(2), PDE6B(1), PDE6C(4), PDE6H(1), TF(2) 22405421 40 39 40 6 3 8 11 10 8 0 0.0960 0.972 1.000 198 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT2(1), G6PC(1), GAA(1), GALE(1), GALK2(1), GALT(1), GANAB(3), GCK(1), GLB1(1), HK1(1), HK2(2), HK3(4), LCT(9), MGAM(6), PFKM(1), PFKP(2) 20360478 39 37 39 6 8 5 14 7 5 0 0.0386 0.972 1.000 199 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CALM3(1), CCL4(1), CXCL12(1), FOS(1), GNAQ(1), MAPK14(2), MAPK8(1), PLCG1(2), PRKCA(2), PTK2B(3) 8795588 16 16 16 4 3 3 6 3 1 0 0.456 0.976 1.000 200 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNA2(1), CDKN1B(1), E2F2(2), E2F4(1), PRB1(1) 5337264 8 8 8 3 2 2 1 3 0 0 0.706 0.976 1.000 201 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CTH(1) 2995771 1 1 1 1 0 0 0 1 0 0 0.964 0.977 1.000 202 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(1), ALDOC(1), G6PD(5), GPI(2), PFKM(1), PFKP(2), PGD(1), PRPS1L1(2), RPIA(1), TKT(2) 13029358 19 16 19 3 4 6 6 3 0 0 0.0701 0.979 1.000 203 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACB(8), MCAT(2), OXSM(1) 8216433 11 11 11 3 2 3 4 1 1 0 0.523 0.980 1.000 204 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(7), ACTN3(2), CTNNA1(3), CTNNB1(2), PECAM1(2), PTK2(2), PXN(2), SRC(1), VCL(6) 11698213 27 26 26 6 4 3 11 3 6 0 0.290 0.981 1.000 205 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(1), TAT(2), TYR(1) 3169437 6 6 6 4 0 1 1 3 1 0 0.958 0.981 1.000 206 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), CYP11B1(8), CYP11B2(4), HSD17B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SRD5A2(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1) 17961173 38 38 38 8 6 4 14 9 5 0 0.170 0.981 1.000 207 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(6), MAP3K1(2), MAPK14(2), NCOR2(3), RARA(1), RXRA(2) 9825549 16 15 16 4 2 2 4 4 4 0 0.593 0.982 1.000 208 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CAMKK1(1) 7311688 10 10 10 3 1 2 3 3 1 0 0.632 0.982 1.000 209 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(8), ATR(3), CDC25A(1), CDC25B(2), CDKN1A(1), CHEK2(3), EP300(2), MYT1(1), PRKDC(7), RPS6KA1(1) 24942345 29 29 29 3 4 3 7 9 6 0 0.0753 0.982 1.000 210 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(11), CDH1(2), CREBBP(11), EP300(2), MAP3K7(2), SKIL(2), TGFB2(1), TGFBR1(1), TGFBR2(3) 17165223 35 30 35 6 1 4 11 12 7 0 0.281 0.983 1.000 211 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(5), CALCRL(4), CD97(3), ELTD1(1), EMR1(1), EMR2(2), GHRHR(2), GIPR(1), LPHN1(1), LPHN2(4), LPHN3(6), SCTR(1), VIPR2(1) 17308538 34 33 34 6 5 1 10 14 4 0 0.130 0.984 1.000 212 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACPP(2), ENPP1(3), ENPP3(3), FLAD1(2), TYR(1) 6421904 13 13 12 4 3 0 4 3 3 0 0.712 0.984 1.000 213 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 22 GPAA1(1), GPLD1(2), PGAP1(7), PIGA(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGN(1), PIGO(4), PIGT(1), PIGU(1), PIGV(1), PIGX(1), PIGZ(2) 15057540 30 30 29 7 4 5 5 10 6 0 0.359 0.986 1.000 214 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPOR(2), JAK2(1), NFKB1(2), NFKBIA(2), RELA(1) 7858336 9 8 9 2 2 2 1 1 3 0 0.609 0.987 1.000 215 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 25 CASP6(2), CASP7(1), CASP8(2), DAXX(3), DFFB(1), FADD(1), LMNA(3), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(7), PTPN13(5), RIPK2(2), SPTAN1(4) 25826762 41 37 41 5 3 8 12 11 7 0 0.0488 0.988 1.000 216 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), OPRK1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 8198305 8 8 8 2 1 0 1 4 2 0 0.597 0.989 1.000 217 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), DUSP1(1), IKBKAP(1), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), TNFAIP3(3), TRAF3(1), TRAF6(2) 11874078 19 18 19 4 5 3 3 6 2 0 0.348 0.990 1.000 218 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), PRMT2(2), PRMT5(2), PRMT8(2) 8839986 9 8 9 2 3 1 3 2 0 0 0.375 0.990 1.000 219 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(3), CTH(1), GGT1(1), MARS(3), MARS2(1), PAPSS1(1), PRMT2(2), PRMT5(2), PRMT8(2), SCLY(2) 15517466 18 16 18 2 4 3 5 5 1 0 0.0641 0.990 1.000 220 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(3), EP300(2), LDHA(1), NOS3(2) 10522035 8 8 8 1 0 0 3 4 1 0 0.437 0.991 1.000 221 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(2) 3310977 2 2 2 3 1 0 0 0 1 0 0.954 0.991 1.000 222 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(1), ATM(8), ATR(3), CCNA1(2), CDC25A(1), CDKN1A(1), CDKN1B(1), HDAC1(1), SKP2(2), TFDP1(3), TGFB2(1) 18018675 24 24 24 4 2 5 7 5 5 0 0.237 0.992 1.000 223 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(2), GRB2(2), PRKCA(2), SRC(1) 6053182 8 8 8 3 1 0 5 0 2 0 0.789 0.992 1.000 224 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), CRY1(2), CSNK1E(1), PER1(3) 5217697 8 8 8 4 0 1 2 3 2 0 0.898 0.992 1.000 225 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(2), L1CAM(8), LYN(2), SELP(3) 10470710 21 19 21 5 6 3 5 4 3 0 0.300 0.992 1.000 226 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C5(3), C6(4), C7(3), ICAM1(1), IL8(3), ITGA4(3), ITGAL(6), ITGB2(2), SELP(3), TNF(1), VCAM1(1) 15915864 31 27 31 7 3 6 6 9 7 0 0.174 0.992 1.000 227 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), DHRS2(1), DHRS7(2), PRMT2(2), PRMT5(2), PRMT8(2) 8951446 12 11 12 3 3 3 3 2 1 0 0.306 0.993 1.000 228 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(2), CTH(1), GOT1(1), LDHA(1), LDHB(1), SDS(1), SULT1B1(1), SULT1C2(1), SULT1C4(1) 8094555 10 10 10 3 0 0 6 2 2 0 0.861 0.993 1.000 229 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(8), BMPR1B(1), CDKN1B(1), EGR1(2), ESR2(2), FSHR(7), INHA(1), LHCGR(4), MLH1(2), MSH5(3), NCOR1(1), NRIP1(2), PGR(1), PRLR(2), VDR(1), ZP2(3) 22683099 41 38 41 6 3 4 13 14 7 0 0.106 0.994 1.000 230 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BIRC3(2), CASP8(2), FADD(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), TNF(1), TNFAIP3(3), TNFRSF1A(2), TRAF2(1) 16551553 24 23 24 4 1 5 10 4 4 0 0.220 0.994 1.000 231 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(3), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), DDC(2), EPX(2), GOT1(1), HPD(3), LPO(1), MAOA(2), MAOB(1), MPO(2), MYST3(5), MYST4(6), SH3GLB1(1), TAT(2), TPO(6) 22370833 46 43 46 8 4 4 16 14 8 0 0.115 0.994 1.000 232 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(3), AGXT2(3), ALAS1(1), ALAS2(1), AOC2(4), AOC3(2), BHMT(2), CHDH(1), CHKA(1), CPT1B(5), CTH(1), DMGDH(2), GARS(1), GATM(1), GLDC(3), MAOA(2), MAOB(1), PLCB2(3), PLCG1(2), PLCG2(1), PSPH(1), SARDH(2), SARS(1), SHMT1(2), SHMT2(1), TARS(2) 26238345 49 46 49 8 6 3 16 15 9 0 0.131 0.995 1.000 233 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 35 ATF2(2), GCK(1), MAP2K4(2), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K7(2), MAP3K9(1), MAPK7(2), MAPK8(1), MAPK9(1), MYEF2(1), PAPPA(4), SHC1(1), TRAF6(2) 31353859 41 39 41 4 7 9 16 5 4 0 0.0101 0.995 1.000 234 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(9), MPI(1), PYGM(3) 8881174 14 14 14 4 1 1 9 1 2 0 0.455 0.996 1.000 235 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR3(5), CXCR3(3), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(1), TGFB2(1) 12931869 16 16 16 4 2 4 5 3 2 0 0.325 0.996 1.000 236 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3) 10843497 12 12 12 3 0 3 6 2 1 0 0.548 0.996 1.000 237 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(2), ANXA5(2), ANXA6(1), CYP11A1(2), EDNRA(2), EDNRB(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGFR(3), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2) 13516147 23 23 22 5 7 2 8 3 3 0 0.297 0.997 1.000 238 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 20 ALDOA(1), ALDOB(1), ALDOC(1), GOT1(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PGK1(1), PKLR(1), RPIA(1), TKT(2) 11167890 15 15 15 4 4 2 4 4 1 0 0.460 0.997 1.000 239 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(3), HEXB(1), HPSE(1), HPSE2(2), IDS(2), LCT(9), MAN2B1(3), MAN2B2(2), MANBA(1), NAGLU(2), NEU1(1), NEU2(1), NEU3(1), SPAM1(6) 20977518 40 38 40 8 4 8 13 11 4 0 0.114 0.997 1.000 240 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(6), GNA12(1), GNAQ(1), MYL2(1), MYLK(6), PLCB1(6), PPP1R12B(3), PRKCA(2) 13676138 28 27 28 6 3 4 11 8 2 0 0.269 0.997 1.000 241 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(2), SDHA(1), SDHC(1) 4312974 5 5 5 3 0 2 1 1 1 0 0.914 0.997 1.000 242 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB1(1), PSMB4(2), PSMB6(1), PSMC3(4), PSMD14(1), RPN1(2), RPN2(2) 8717545 13 12 13 5 1 0 5 3 4 0 0.871 0.998 1.000 243 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP6(2), ACPP(2), ENPP1(3), ENPP3(3), FLAD1(2), MTMR1(2), MTMR6(4), TYR(1) 9921955 21 20 20 6 5 1 4 6 5 0 0.634 0.998 1.000 244 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 8 ALDOB(1), GPI(2), HK1(1), PGK1(1), PKLR(1) 4921782 6 6 6 3 1 0 3 2 0 0 0.816 0.998 1.000 245 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(2), CYP11B2(4), HSD3B1(2), HSD3B2(1) 4560528 12 12 12 6 1 1 6 3 1 0 0.938 0.998 1.000 246 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 13 ADSL(1), ADSS(1), MTHFD2(1), POLB(2), POLG(2), RRM1(1) 7582726 8 8 8 3 1 3 2 1 1 0 0.749 0.998 1.000 247 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(1) 5178261 4 4 4 3 0 0 2 1 1 0 0.970 0.999 1.000 248 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(3), ACAT2(1), EHHADH(2), HADHA(1), SDS(1) 5501843 9 7 9 5 0 2 5 1 1 0 0.944 0.999 1.000 249 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(3), ACADS(1), ACADVL(2), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1), SLC25A20(1) 11016623 19 19 19 5 2 4 5 4 4 0 0.472 0.999 1.000 250 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR2B(4), POLR2C(1), POLR2H(1) 7591190 6 6 6 2 1 0 1 3 1 0 0.717 0.999 1.000 251 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), PTPRU(1), STAT1(2), STAT2(2), TYK2(2) 8020279 9 9 9 3 0 1 5 3 0 0 0.742 0.999 1.000 252 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(2), CHUK(1), GH1(1), NFKB1(2), NFKBIA(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), RELA(1) 9261511 17 16 17 7 1 2 6 3 5 0 0.897 0.999 1.000 253 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2B(2), GTF2E1(1), HDAC3(2), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(3), RARA(1), RXRA(2), TBP(1) 15110766 22 22 22 7 1 3 4 4 10 0 0.729 0.999 1.000 254 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25B(2), MNAT1(1) 5772182 5 5 5 3 0 0 4 0 1 0 0.972 0.999 1.000 255 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(1), MAP3K14(1), MAPK14(2), MAPK8(1), NFKB1(2), RELA(1), TRAF2(1), TRAF3(1), TRAF5(1), TRAF6(2) 9244702 13 13 13 4 3 4 3 3 0 0 0.561 0.999 1.000 256 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1) 8153687 13 12 13 5 2 1 3 4 3 0 0.743 0.999 1.000 257 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(1), MMP9(1), RECK(3) 4885712 5 5 5 6 1 0 2 1 1 0 0.984 0.999 1.000 258 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 25 CASP8(2), DFFB(1), FADD(1), LMNA(3), MADD(6), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(7), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF2(1) 23757536 38 36 38 6 5 10 9 7 7 0 0.0889 0.999 1.000 259 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 DBH(2), DDC(2), GAD1(1), GAD2(2), HDC(2), MAOA(2), PAH(3), SLC18A3(1) 8687479 15 15 15 9 1 1 4 5 4 0 0.938 0.999 1.000 260 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFB2(1), NDUFB5(1), NDUFS1(1), NDUFV1(1) 4413522 4 4 4 2 0 0 1 3 0 0 0.849 0.999 1.000 261 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2) 5207103 8 8 8 4 0 4 1 2 1 0 0.815 0.999 1.000 262 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2) 5207103 8 8 8 4 0 4 1 2 1 0 0.815 0.999 1.000 263 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(1), ALOX15(2), ALOX5(2), CYP4F2(2), EPX(2), GGT1(1), LPO(1), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PRDX5(1), PTGDS(1), PTGES2(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2), TPO(6) 17435981 34 32 34 7 5 6 17 4 2 0 0.0857 0.999 1.000 264 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(6), ITGAM(1), ITGB2(2), PECAM1(2), SELE(2) 6792914 14 14 14 5 2 4 4 3 1 0 0.597 0.999 1.000 265 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(2), DPYD(2), DPYS(1), ENPP1(3), ENPP3(3), PANK3(1), PANK4(2), UPB1(2) 8528619 16 16 15 6 3 1 4 5 3 0 0.735 0.999 1.000 266 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(2), COASY(2), DPYD(2), DPYS(1), ENPP1(3), ENPP3(3), ILVBL(1), PANK3(1), PANK4(2), UPB1(2), VNN1(2) 10761365 21 21 20 8 3 1 6 6 5 0 0.803 0.999 1.000 267 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(2), E2F4(1), ETS1(1), ETS2(1), FOS(1), HDAC5(1), NCOR2(3), RBL1(1), RBL2(3), SIN3A(1), SIN3B(3) 15139956 19 17 19 4 4 2 8 2 3 0 0.276 0.999 1.000 268 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(2), BRAF(2), CREB3(1), SRC(1) 7518188 6 6 6 4 0 1 2 1 2 0 0.975 0.999 1.000 269 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 9 FOS(1), MAPK14(2), MAPK8(1), PRKCA(2) 5321336 6 6 6 5 2 1 0 2 1 0 0.972 0.999 1.000 270 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(2), G6PD(5), GCLM(1), GGT1(1), GPX6(3), GSR(2), GSS(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM4(1), GSTO2(1), IDH1(1), MGST2(1), TXNDC12(2) 13090401 27 25 27 7 0 8 11 6 2 0 0.347 0.999 1.000 271 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 CASP8(2), FADD(1), MAP2K4(2), MAP3K1(2), MAPK8(1), NFKB1(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRAF2(1) 13077015 15 15 15 4 2 5 4 2 2 0 0.411 0.999 1.000 272 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CSNK1D(1), PPP2CA(2) 5646578 3 3 3 3 0 0 2 0 1 0 0.960 0.999 1.000 273 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 17 ACY1(1), ARG1(1), ARG2(1), ASL(1), CPS1(6), GATM(1), GLUD1(1), ODC1(2), OTC(1) 10389159 15 15 15 9 1 2 4 4 4 0 0.983 0.999 1.000 274 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), NAT2(2), XDH(2) 5357788 11 11 11 5 1 3 4 2 1 0 0.688 1.000 1.000 275 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 NRF1(1), UBE2D3(1), UBE2M(1) 6228191 3 3 3 2 2 0 0 1 0 0 0.867 1.000 1.000 276 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), MDH1(1), ME1(2), PC(1) 5831001 6 6 6 5 1 0 4 0 1 0 0.983 1.000 1.000 277 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1C4(2), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(1), HSD3B7(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SLC27A5(1), SOAT2(2), SRD5A1(1), SRD5A2(1) 20574948 35 32 35 8 4 7 11 7 6 0 0.263 1.000 1.000 278 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(3), AGXT2(3), ALAS1(1), ALAS2(1), AOC2(4), AOC3(2), BHMT(2), CHDH(1), CHKA(1), CTH(1), DMGDH(2), GARS(1), GATM(1), GLDC(3), HSD3B7(1), MAOA(2), MAOB(1), PSAT1(1), PSPH(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SARDH(2), SARS(1), SARS2(1), SDS(1), SHMT1(2), SHMT2(1), TARS(2), TARS2(1) 27292608 47 42 47 8 6 2 16 12 11 0 0.170 1.000 1.000 279 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(7), MAP2(10), PPP2CA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(2), PRKAR2B(1), PRKCE(1) 12011070 26 24 26 9 2 1 11 7 5 0 0.857 1.000 1.000 280 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), GPR109B(1), GPR34(3), GPR45(1), GPR75(1) 6420492 8 8 8 4 3 1 4 0 0 0 0.689 1.000 1.000 281 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGFR(6), HGS(2), TF(2), TFRC(3) 8447216 16 15 16 5 2 1 9 3 1 0 0.737 1.000 1.000 282 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(11), EP300(2), IL7R(4), JAK3(4), LCK(1), PIK3CA(3), PIK3R1(2), PTK2B(3), STAT5B(3) 17945678 33 33 33 8 1 3 11 10 8 0 0.530 1.000 1.000 283 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(2), ACE2(2), AGTR2(2), ANPEP(2), CPA3(1), CTSA(2), CTSG(2), ENPEP(1), LNPEP(2), MAS1(1), MME(5), REN(2) 13236112 24 23 24 7 3 5 8 6 2 0 0.556 1.000 1.000 284 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), HADHA(1), SDS(1) 7884200 12 12 12 6 0 4 4 2 2 0 0.901 1.000 1.000 285 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(2), EPOR(2), FOS(1), GRB2(2), JAK2(1), MAPK8(1), PLCG1(2), SHC1(1), SOS1(4), STAT5B(3) 13808389 21 20 21 5 1 4 11 4 1 0 0.431 1.000 1.000 286 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(1), HMGCR(2), MVK(1), NQO1(1), NQO2(1), SQLE(1) 6538725 7 7 7 4 1 2 1 2 1 0 0.868 1.000 1.000 287 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP51A1(1), DHCR24(1), DHCR7(1), EBP(2), GGCX(1), HMGCR(2), IDI2(1), MVK(1), NQO1(1), SQLE(1), TM7SF2(1) 11931449 13 13 13 4 3 4 2 2 2 0 0.544 1.000 1.000 288 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), PAK1(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), WASL(1) 8890020 14 14 14 8 0 4 4 4 2 0 0.972 1.000 1.000 289 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 CAT(1), GH1(1), IGF1R(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOD1(1) 8413207 10 10 10 6 1 2 4 1 2 0 0.926 1.000 1.000 290 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(1), ACP2(1), ACP6(2), ACPP(2), ALPI(2), ALPL(2), ALPP(2), CYP3A43(1), DHRS2(1), DHRS7(2), PON3(1) 10921862 17 17 17 8 2 5 4 2 4 0 0.834 1.000 1.000 291 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 27 ATG12(1), ATG3(3), ATG7(1), BECN1(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), PIK3C3(2), PIK3R4(4), PRKAA2(2) 12445317 21 21 21 5 0 2 10 8 1 0 0.609 1.000 1.000 292 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), CALM2(1), CALM3(1), GNAS(3), NFKB1(2), NOS3(2), NPPA(1), NR3C1(2), PIK3CA(3), PIK3R1(2), RELA(1) 10723321 19 19 18 9 1 2 6 6 4 0 0.955 1.000 1.000 293 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10(2), STAT1(2), STAT3(1), TNF(1) 7976177 6 6 6 4 0 1 3 0 2 0 0.935 1.000 1.000 294 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(3), ARHGEF1(6), F2(3), F2R(3), GNA12(1), GNAQ(1), MAP3K7(2), PIK3CA(3), PIK3R1(2), PLCB1(6), PPP1R12B(3), PRKCA(2), PTK2B(3) 16500483 38 34 38 9 8 8 14 6 2 0 0.256 1.000 1.000 295 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(3), PIK3R1(2), PLCB1(6), PLCG1(2), PRKCA(2), VAV1(3) 8539672 18 17 18 7 2 2 8 4 2 0 0.869 1.000 1.000 296 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1) 11536846 15 14 15 5 2 1 3 5 4 0 0.609 1.000 1.000 297 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), DUSP1(1), IKBKAP(1), IKBKB(2), LTA(1), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), TNFAIP3(3), TRAF1(3), TRAF2(1), TRAF3(1) 14562200 22 21 22 5 5 3 4 7 3 0 0.409 1.000 1.000 298 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(2), IL4R(1), IRS1(3), JAK3(4), SHC1(1), STAT6(4) 9314094 15 14 15 7 2 3 4 3 3 0 0.783 1.000 1.000 299 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB1(1), PSMB4(2), PSMB6(1), PSMC3(4), PSMD1(2), PSMD13(1) 10619306 11 10 11 5 0 0 6 2 3 0 0.904 1.000 1.000 300 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(2), CD3G(1), CXCR3(3), ETV5(1), IL12RB1(1), IL12RB2(2), IL18R1(2), JAK2(1), MAP2K6(1), MAPK14(2), MAPK8(1), STAT4(2), TYK2(2) 12041248 21 21 21 6 2 4 6 6 3 0 0.538 1.000 1.000 301 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(3), CD5(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), ITGAX(2), TLR2(1), TLR4(5), TLR7(2), TLR9(1) 12179855 23 21 23 7 0 7 6 8 2 0 0.517 1.000 1.000 302 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 CYP51A1(1), DHCR7(1), HMGCR(2), MVK(1), SQLE(1) 7953803 6 6 6 3 1 3 1 1 0 0 0.750 1.000 1.000 303 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(1), JAK3(4), STAT3(1), TYK2(2) 7350053 8 8 8 5 1 1 2 3 1 0 0.913 1.000 1.000 304 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CSF1(1), IL6R(1), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF8(2), TNFSF8(1) 8595650 11 11 11 5 3 3 2 1 2 0 0.698 1.000 1.000 305 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(3), ITGAL(6), ITGAM(1), ITGB2(2), PECAM1(2), SELE(2), SELP(3) 10408804 20 19 20 7 2 4 6 5 3 0 0.685 1.000 1.000 306 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CCNH(1), CDC25A(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), RBL1(1), TFDP1(3) 9004235 12 12 12 7 2 3 4 1 2 0 0.937 1.000 1.000 307 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(3), IKBKB(2), JAK2(1), LIN7A(2), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), USH1C(2) 9985186 18 17 18 5 3 4 4 3 4 0 0.456 1.000 1.000 308 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(3), ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), AOX1(5), DBH(2), DCT(3), DDC(2), GOT1(1), HPD(3), MAOA(2), MAOB(1), TAT(2), TPO(6), TYR(1) 19826165 44 40 44 10 4 5 13 15 7 0 0.245 1.000 1.000 309 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(1), KLRC1(1), KLRC2(1), KLRC3(1), PAK1(1), PIK3CA(3), PIK3R1(2), PTK2B(3), VAV1(3) 12196205 18 17 17 9 0 1 7 6 4 0 0.978 1.000 1.000 310 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(2), G6PD(5), GCLM(1), GGT1(1), GSS(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTM4(1), GSTO2(1), IDH1(1), MGST2(1), PGD(1) 11724732 20 18 20 6 0 7 9 4 0 0 0.456 1.000 1.000 311 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), CALM3(1), DLG4(1), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), NOS1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2) 15872801 29 27 28 8 7 3 6 7 6 0 0.420 1.000 1.000 312 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGTR2(2), EDNRA(2), EDNRB(1), EGFR(6), FOS(1), NFKB1(2), PLCG1(2), PRKCA(2), RELA(1) 13698062 22 21 21 6 8 3 7 2 2 0 0.356 1.000 1.000 313 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IL2RA(1), IL2RB(1), JAK3(4), LCK(1), MAPK8(1), SHC1(1), SOS1(4), STAT5B(3) 14976386 23 22 23 6 1 5 12 4 1 0 0.364 1.000 1.000 314 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(3), GALNT1(3), GALNT12(1), GALNT13(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(1), GALNT6(2), GALNT8(1), GALNTL2(1), GALNTL5(1), GCNT3(2), GCNT4(4), OGT(3), ST3GAL2(2), ST6GALNAC1(1), WBSCR17(1) 21363374 33 31 33 7 5 4 11 9 4 0 0.309 1.000 1.000 315 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), ASPA(1), CARM1(3), DDC(2), HAL(1), HDC(2), HNMT(1), MAOA(2), MAOB(1), PRMT2(2), PRMT5(2), PRMT8(2), UROC1(3) 24979906 39 38 39 8 6 5 9 13 6 0 0.161 1.000 1.000 316 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(2), CASP1(3), CASP7(1), CASP8(2), GAPDH(1), INSR(5), MAGI1(1), MAGI2(4), RERE(1), WWP2(1) 15107549 21 21 21 5 3 3 8 6 1 0 0.473 1.000 1.000 317 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 65 RPL10A(1), RPL10L(1), RPL14(1), RPL22L1(1), RPL23A(1), RPL30(1), RPL32(1), RPL8(1), RPS10(2), RPS3(1), RPS6(1), RPS9(1) 12778792 13 12 13 7 2 2 3 1 5 0 0.923 1.000 1.000 318 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), BDKRB2(4), CALM2(1), CALM3(1), CHRNA1(1), FLT1(3), FLT4(1), KDR(7), NOS3(2), PDE2A(4), PDE3A(3), PDE3B(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKG1(3), RYR2(22) 25072161 60 53 60 12 6 7 22 18 7 0 0.123 1.000 1.000 319 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT2(1), B4GALT5(3), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), RPN1(2), RPN2(2) 12202466 19 19 19 6 2 1 8 4 4 0 0.704 1.000 1.000 320 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP3A43(1), HSD3B7(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 15701400 27 26 27 7 2 2 16 5 2 0 0.444 1.000 1.000 321 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(3), AOC2(4), AOC3(2), CES7(4), DDHD1(1), MYST3(5), MYST4(6), PLA1A(1), SH3GLB1(1) 16726024 27 27 27 7 1 3 8 8 7 0 0.600 1.000 1.000 322 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(2), BIK(1), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1) 8789303 13 13 13 6 0 3 5 4 1 0 0.882 1.000 1.000 323 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), FADD(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), PARP1(3), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFSF10(1), TRAF1(3), TRAF2(1) 23343051 34 31 34 7 4 7 9 7 7 0 0.203 1.000 1.000 324 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 21 APC(11), CREB3(1), DAG1(3), EPHB2(2), FOS(1), GNAQ(1), ITPKB(4), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1) 15729958 28 24 28 8 3 4 10 8 3 0 0.598 1.000 1.000 325 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 ADAM17(1), APC(11), AXIN1(1), BTRC(1), CTNNB1(2), FZD1(1) 10268171 17 16 17 5 0 3 6 6 2 0 0.664 1.000 1.000 326 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), DHRS7(2), MYST3(5), MYST4(6), SH3GLB1(1) 10588810 15 15 15 5 0 4 5 4 2 0 0.712 1.000 1.000 327 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(3), CAP1(1), GNAS(3), MYT1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RPS6KA1(1), SRC(1) 12310310 17 17 16 6 4 0 4 5 4 0 0.716 1.000 1.000 328 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), ASPA(1), DDC(2), HAL(1), HDC(2), HNMT(1), MAOA(2), MAOB(1) 16164688 27 27 27 8 2 4 6 9 6 0 0.544 1.000 1.000 329 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK2(1), JAK3(4), PTPRU(1) 8853351 6 6 6 3 1 1 1 2 1 0 0.731 1.000 1.000 330 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), FOS(1), NFKB1(2), NFKBIA(2), PLCB1(6), PRKCA(2), RELA(1), TNF(1) 10120162 16 14 16 6 2 4 5 2 3 0 0.735 1.000 1.000 331 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C8B(2), C9(1), MASP1(3) 13768503 20 19 20 8 3 1 7 5 4 0 0.780 1.000 1.000 332 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(3), PER2(1), PER3(2) 10506543 15 14 14 7 0 2 4 7 2 0 0.876 1.000 1.000 333 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1), MASP1(3), MASP2(3), MBL2(1) 13924905 22 21 22 8 3 2 6 7 4 0 0.684 1.000 1.000 334 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), DHRS2(1), DHRS7(2), MYST3(5), MYST4(6), SH3GLB1(1) 16198796 24 23 24 7 0 6 8 5 5 0 0.604 1.000 1.000 335 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(2), ABCB4(6), ABCC1(3), ABCC3(1) 9652853 17 16 17 7 5 0 5 6 1 0 0.756 1.000 1.000 336 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(3), CSF2RB(2), IGF1R(1), KIT(8), KITLG(1), PIK3CA(3), PIK3R1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 13445036 26 26 26 9 7 3 6 6 4 0 0.628 1.000 1.000 337 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), ACO2(1), DLST(1), FH(1), IDH1(1), IDH3A(1), MDH1(1), MDH2(2), PC(1), SDHA(1) 13394634 11 11 11 7 1 1 2 3 4 0 0.964 1.000 1.000 338 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 GAL3ST1(1), GLB1(1), LCT(9), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), SPTLC1(2) 14710990 18 18 18 6 2 3 7 2 4 0 0.593 1.000 1.000 339 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), BTRC(1), CDC16(2), CDC20(4), CDC23(1), CDC27(5), CUL1(2), CUL2(2), CUL3(1), FBXW11(1), FBXW7(5), SKP2(2), SMURF1(2), TCEB1(1), UBA1(3), UBE2D3(1), WWP2(1) 25670859 38 34 38 8 8 4 14 3 9 0 0.438 1.000 1.000 340 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), HDAC5(1), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(1) 12756510 16 16 16 5 1 3 6 5 1 0 0.667 1.000 1.000 341 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 57 ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(1), FUT1(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), PIGA(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGN(1), PIGO(4), PIGT(1), PIGU(1), PIGV(1), PIGX(1), PIGZ(2), ST3GAL2(2), ST3GAL3(3), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST8SIA1(3), ST8SIA5(1) 29365280 53 49 53 11 11 11 11 10 10 0 0.0977 1.000 1.000 342 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(1), JAK2(1), JAK3(4), PTPRU(1), SRC(1), STAT3(1) 9781756 9 9 9 5 2 1 3 2 1 0 0.829 1.000 1.000 343 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(2), BIRC3(2), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1), LMNA(3), PRF1(1) 12222684 20 20 20 6 2 2 7 7 2 0 0.638 1.000 1.000 344 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 APAF1(2), ATM(8), CASP6(2), CASP7(1), CASP9(2), EIF2S1(1), PRKCA(2), PTK2(2), PXN(2), STAT1(2) 17711570 24 24 24 6 3 2 8 5 6 0 0.560 1.000 1.000 345 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(2), IARS2(3), ILVBL(1), LARS(1), LARS2(2), VARS(3), VARS2(3) 12248895 15 15 15 6 3 1 6 3 2 0 0.845 1.000 1.000 346 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CMAS(1), CYB5R1(1), GFPT2(1), GNPDA2(1), HEXA(3), HEXB(1), HK1(1), HK2(2), HK3(4), MTMR1(2), MTMR6(4), NANS(1), RENBP(2), UAP1(2) 18431673 26 23 26 7 6 3 5 7 5 0 0.477 1.000 1.000 347 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(1), PIK3CA(3), PIK3R1(2), POLR1A(2) 10621413 8 8 8 8 1 1 3 2 1 0 0.992 1.000 1.000 348 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC3(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1), PRF1(1), SCAP(2), SREBF1(1), SREBF2(1) 10978578 15 15 15 5 1 2 6 5 1 0 0.705 1.000 1.000 349 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGFR(6), GRB2(2), MET(4), PDGFRA(2), PRKCA(2), SH3GLB1(1), SH3KBP1(1), SRC(1) 13026267 21 20 21 7 1 3 8 6 3 0 0.651 1.000 1.000 350 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ACY1(1), ADC(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AMD1(1), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(6), GATM(1), MAOA(2), MAOB(1), ODC1(2), OTC(1) 19135728 39 36 39 10 2 6 10 11 10 0 0.494 1.000 1.000 351 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10(1), ALG10B(4), ALG11(2), ALG2(3), ALG8(2), ALG9(1), B4GALT2(1), DAD1(2), DHDDS(1), DPAGT1(1), DPM1(1), FUT8(1), GANAB(3), MAN1A1(2), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), MGAT5B(2), RFT1(1), RPN1(2), RPN2(2), STT3B(3) 26798649 47 44 47 10 5 6 16 10 10 0 0.241 1.000 1.000 352 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CALM3(1), CHUK(1), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(3), NFKB1(2), NFKBIA(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RELA(1), VIPR2(1) 17313791 28 27 28 8 6 3 7 8 4 0 0.529 1.000 1.000 353 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 EGFR(6), IGF1R(1), PPP2CA(2), PRKCA(2), TEP1(9), TERF1(1), TERT(1), TNKS(1) 16480620 23 23 23 7 6 2 7 3 5 0 0.431 1.000 1.000 354 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 JAK2(1), JAK3(4), STAT1(2), STAT3(1), STAT5B(3), TYK2(2) 11427841 13 13 13 5 1 1 7 3 1 0 0.759 1.000 1.000 355 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 23 ATF1(2), CHUK(1), IKBKB(2), LTA(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF2(1) 15084558 24 23 24 7 4 5 6 5 4 0 0.593 1.000 1.000 356 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), G6PC(1), GAA(1), GANAB(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), GYS2(3), HK1(1), HK2(2), HK3(4), MGAM(6), PYGB(2), PYGM(3), SI(10), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1), UXS1(2) 36688445 70 64 68 14 11 8 22 17 12 0 0.0747 1.000 1.000 357 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 ATF1(2), CREB3(1), DUSP1(1), EEF2K(1), ELK1(2), MAP2K4(2), MAP2K6(1), MAP3K10(3), MAP3K4(2), MAP3K5(5), MAP3K7(2), MAPK14(2), MAPKAPK5(1), MKNK1(2), MYEF2(1), NFKB1(2), SRF(1), TRAF6(2) 21118761 33 32 33 9 5 5 11 6 6 0 0.531 1.000 1.000 358 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CD8A(1), CD8B(1), CIITA(1), CTSL1(4), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-G(3), HSP90AA1(2), HSPA5(3), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), KIR2DL1(1), KIR2DL3(3), KIR2DL4(2), KIR3DL1(3), KIR3DL2(1), KIR3DL3(2), KLRC1(1), KLRC2(1), KLRC3(1), LTA(1), NFYC(1), PDIA3(1), PSME1(2), PSME2(1), RFX5(1), RFXANK(1), RFXAP(1), TAPBP(3) 30036423 57 52 56 13 6 10 17 15 9 0 0.219 1.000 1.000 359 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADM(3), ACADS(1), ACADSB(1), ACADVL(2), ACAT1(3), ACAT2(1), ACOX1(1), ACOX3(1), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A11(6), CYP4A22(2), EHHADH(2), GCDH(1), HADHA(1), HSD17B4(1) 31863790 58 53 57 13 3 16 17 13 9 0 0.137 1.000 1.000 360 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(1), F13B(1), F2(3), F5(8), F7(1), F8(6), F9(1), FGA(3), FGB(2), LPA(7), PLAU(2), PLG(4), SERPINB2(1), SERPINE1(2), VWF(6) 22697544 49 47 49 12 9 4 20 10 6 0 0.335 1.000 1.000 361 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(3), ACAT2(1), ACOT11(1), DHRS2(1), DHRS7(2), EHHADH(2), GCDH(1), HADHA(1), MYST3(5), MYST4(6), SH3GLB1(1), YOD1(3) 16702996 27 23 27 8 0 7 12 5 3 0 0.602 1.000 1.000 362 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), KLK2(1), MAPK8(1), NGFR(2), PIK3CA(3), PIK3R1(2), PLCG1(2), SHC1(1), SOS1(4) 12262525 23 21 23 9 1 5 12 4 1 0 0.837 1.000 1.000 363 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CALM2(1), CALM3(1), EP300(2), HDAC1(1), MEF2D(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CC(1), PRKCA(2) 15135935 16 15 16 6 4 1 4 4 3 0 0.720 1.000 1.000 364 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(1), BCHE(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3) 15432777 19 18 19 8 1 3 8 4 3 0 0.823 1.000 1.000 365 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 79 ANPEP(2), CD19(2), CD1A(1), CD1B(2), CD1C(3), CD1D(1), CD2(3), CD22(3), CD34(1), CD36(2), CD37(1), CD38(2), CD3E(2), CD3G(1), CD5(1), CD55(1), CD8A(1), CD8B(1), CD9(1), CR1(3), CR2(2), CSF1(1), CSF1R(2), CSF3(1), CSF3R(2), DNTT(2), EPOR(2), FCGR1A(2), FLT3(3), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL1R2(1), IL2RA(1), IL4R(1), IL5RA(1), IL6R(1), IL7R(4), ITGA1(2), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGAM(1), KIT(8), KITLG(1), MME(5), MS4A1(2), TFRC(3), THPO(1), TNF(1), TPO(6) 52150033 113 91 113 22 17 15 38 31 12 0 0.0183 1.000 1.000 366 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2B(2), GTF2E1(1), GTF2F2(1), GTF2H4(1), GTF2I(1), GTF2IRD1(2), TAF1(7), TAF12(1), TAF1L(2), TAF2(2), TAF4(2), TAF5(1), TAF5L(1), TAF6(1), TAF6L(3), TBPL2(2) 23513212 30 29 30 7 4 7 9 7 3 0 0.304 1.000 1.000 367 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(3), ALDOA(1), ALDOB(1), ALDOC(1), FPGT(2), HK1(1), HK2(2), HK3(4), HSD3B7(1), MPI(1), MTMR1(2), MTMR6(4), PFKFB1(1), PFKFB2(1), PFKFB3(1), PFKM(1), PFKP(2), PGM2(1), PMM2(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 22699576 35 33 35 9 9 6 12 4 4 0 0.272 1.000 1.000 368 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DFFB(1), FADD(1), GAS2(1), LMNA(3), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), SPTAN1(4), TNFRSF10A(2), TNFSF10(1), TRAF2(1) 21391941 32 30 32 8 5 5 11 7 4 0 0.476 1.000 1.000 369 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(3), F2R(3), ITGA1(2), PLA2G4A(1), PLCB1(6), PRKCA(2), PTGS1(3), PTK2(2), SRC(1), TBXAS1(2) 15977925 25 22 25 8 6 5 9 2 3 0 0.507 1.000 1.000 370 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPS(1), ENPP2(2), PAFAH2(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(2) 15043860 16 16 16 8 1 4 6 3 2 0 0.916 1.000 1.000 371 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AP2A1(2), BTK(2), EEA1(3), GRASP(1), GSK3A(1), LYN(2), PDPK1(1), PFKM(1), PFKP(2), PLCG1(2), PRKCE(1), PRKCZ(2), VAV2(4) 14777817 24 23 24 8 4 2 12 5 1 0 0.613 1.000 1.000 372 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CALM3(1), CDKN1A(1), GNAQ(1), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2) 12909534 16 16 16 7 5 2 5 3 1 0 0.783 1.000 1.000 373 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(7), ACTN3(2), ITGA1(2), PTK2(2), PXN(2), SPTAN1(4), SRC(1) 18528783 21 21 20 7 5 1 10 1 4 0 0.706 1.000 1.000 374 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), CARM1(3), CYP11B1(8), CYP11B2(4), HSD17B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), PRMT2(2), PRMT5(2), PRMT8(2), SRD5A1(1), SRD5A2(1), STS(2), SULT1E1(1), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1) 31644615 59 54 59 13 11 5 22 14 7 0 0.149 1.000 1.000 375 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP12A(3), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), ATP7B(2), COX10(1), COX6B1(1), NDUFB2(1), NDUFB5(1), NDUFS1(1), NDUFV1(1), PPA2(1), SDHA(1), SHMT1(2), UQCRB(1) 23574219 27 27 26 7 5 1 6 10 5 0 0.511 1.000 1.000 376 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(1), CBX3(1), CLOCK(1), CRY1(2), EIF4G2(3), ETV6(1), GFRA1(3), HSPA8(1), KLF9(1), NCKAP1(3), NR1D2(1), PER1(3), PER2(1), PIGF(1), TOB1(1), TUBB3(3), UCP3(1) 23025295 28 27 28 9 1 2 9 10 6 0 0.826 1.000 1.000 377 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACADM(3), ACOX1(1), ACOX3(1), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(1), ANGPTL4(1), CD36(2), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A11(6), CYP4A22(2), CYP7A1(1), CYP8B1(2), EHHADH(2), FABP2(1), FABP3(2), FABP4(1), FABP7(1), FADS2(2), GK2(2), HMGCS2(1), LPL(1), ME1(2), MMP1(2), NR1H3(5), OLR1(1), PCK2(1), PDPK1(1), PPARA(1), PPARD(3), RXRA(2), RXRB(2), RXRG(1), SLC27A2(2), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(1), UBC(2), UCP1(1) 42382630 82 78 81 17 10 15 27 19 11 0 0.0459 1.000 1.000 378 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(4), FOS(1), GRB2(2), JAK2(1), MAP2K4(2), MAP3K1(2), MAPK8(1), PIK3CA(3), PIK3R1(2), SOS1(4), STAT1(2), STAT5B(3) 17557537 27 25 27 9 1 3 15 5 3 0 0.756 1.000 1.000 379 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(1), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), NDST2(3), NDST4(2) 13127569 15 15 15 6 2 2 5 5 1 0 0.765 1.000 1.000 380 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(1), EPRS(1), GUSB(2), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1), UROD(1), UROS(1) 17838652 21 20 21 7 1 5 6 6 3 0 0.596 1.000 1.000 381 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 APC(11), AXIN1(1), CTNNB1(2), FZD1(1), GJA1(2), IRAK1(3), LBP(1), LEF1(1), LY96(1), MYD88(1), NFKB1(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), RELA(1), TIRAP(1), TLR4(5) 18195852 41 37 41 11 3 8 17 8 5 0 0.490 1.000 1.000 382 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), F10(1), F11(1), F2(3), F2R(3), F5(8), F8(6), F9(1), FGA(3), FGB(2), KLKB1(1), PROS1(1), SERPINC1(2) 28906582 59 55 59 14 7 11 21 13 7 0 0.297 1.000 1.000 383 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(2), BIN1(3), CALM2(1), CALM3(1), DNM1(1), PICALM(3), PPP3CA(1), PPP3CC(1), SYNJ1(6) 14205144 21 21 21 8 3 6 5 6 1 0 0.723 1.000 1.000 384 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP4A11(6), CYP4A22(2), CYP4F2(2), DHRS4(1), EPHX2(3), GGT1(1), GPX6(3), LTA4H(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PTGDS(1), PTGES2(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2) 24374917 50 47 49 12 4 10 25 8 3 0 0.117 1.000 1.000 385 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(2), ADRBK2(2), ARRB2(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CLCA1(2), CLCA2(2), CLCA4(4), CNGA3(6), GNAL(2), GUCA1B(1), PDE1C(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKG1(3) 19663467 37 35 37 10 6 3 18 8 2 0 0.396 1.000 1.000 386 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 34 DEGS2(1), ENPP7(1), GAL3ST1(1), GLB1(1), LCT(9), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), SGPP1(1), SPTLC1(2) 20730075 21 21 21 7 3 4 8 2 4 0 0.512 1.000 1.000 387 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(4), AASDHPPT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), BBOX1(1), DLST(1), EHHADH(2), EHMT2(2), GCDH(1), HADHA(1), PLOD1(2), PLOD2(1), PLOD3(2), SDS(1), SHMT1(2), SHMT2(1), TMLHE(1) 22796413 38 33 38 10 5 8 10 11 4 0 0.305 1.000 1.000 388 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), DLST(1), FH(1), IDH3A(1), MDH1(1), MDH2(2), OGDH(3), PC(1), PDHX(1), PDK1(1), PDK3(2), SDHA(1), SDHC(1) 18443361 18 17 18 9 2 2 7 4 3 0 0.914 1.000 1.000 389 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(1), ACO2(1), DLST(1), FH(1), IDH1(1), IDH3A(1), MDH1(1), MDH2(2), OGDH(3), PC(1), PCK2(1), SDHA(1), SDHC(1) 19615762 18 18 18 8 2 2 6 4 4 0 0.874 1.000 1.000 390 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGTR2(2), COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), REN(2) 16591394 33 32 33 10 4 6 9 9 5 0 0.443 1.000 1.000 391 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1) 15427653 10 10 10 7 2 1 2 4 1 0 0.951 1.000 1.000 392 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(1), CDC7(1), DIAPH2(5), GMNN(1), MCM10(3), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), NACA(3), ORC1L(2), ORC2L(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), RFC1(2), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA4(2), RPS27A(1), UBA52(1), UBC(2) 31977481 48 46 48 10 7 6 16 13 6 0 0.209 1.000 1.000 393 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(3), APC(11), ATF2(2), AXIN1(1), BMP10(2), BMP2(1), BMP4(1), BMP5(1), BMPR2(3), CHRD(2), CTNNB1(2), FZD1(1), MAP3K7(2), MEF2C(1), MYL2(1), NPPA(1), NPPB(3), RFC1(2), TGFB2(1), TGFBR1(1), TGFBR2(3), TGFBR3(4) 22554773 49 41 49 12 3 7 24 11 4 0 0.402 1.000 1.000 394 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), FOS(1), GRB2(2), JAK2(1), MPL(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), STAT1(2), STAT3(1), STAT5B(3), THPO(1) 19577385 30 29 30 9 3 3 16 6 2 0 0.686 1.000 1.000 395 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 28 ANKRD6(2), APC(11), AXIN1(1), AXIN2(2), CTNNB1(2), DACT1(3), DKK1(1), DKK2(3), GSK3A(1), LRP1(12), MVP(3), SENP2(1), TSHB(1), WIF1(2) 24907004 45 42 45 11 10 4 14 11 6 0 0.272 1.000 1.000 396 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 53 ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AGK(2), AKR1A1(2), AKR1B1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CEL(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), GK2(2), GLB1(1), GPAM(2), LCT(9), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(2) 36924006 61 54 61 14 5 13 25 12 6 0 0.152 1.000 1.000 397 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(1), BMP4(1), BMP5(1), BMP6(1), BTRC(1), CSNK1A1L(1), CSNK1D(1), CSNK1E(1), FBXW11(1), GLI1(6), GLI2(10), GLI3(2), HHIP(2), LRP2(14), PRKACA(1), PRKACB(1), PRKACG(1), PTCH1(6), PTCH2(1), RAB23(1), STK36(3), SUFU(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1) 37132573 76 65 75 17 13 13 30 14 6 0 0.113 1.000 1.000 398 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(1), ALDOB(1), ALDOC(1), FPGT(2), GCK(1), HK1(1), HK2(2), HK3(4), MPI(1), PFKFB1(1), PFKFB3(1), PFKM(1), PFKP(2), PMM2(1) 15417085 23 22 23 8 7 5 7 2 2 0 0.504 1.000 1.000 399 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(11), AXIN1(1), CREBBP(11), CTNNB1(2), EP300(2), FZD1(1), HDAC1(1), LEF1(1), PITX2(1), TRRAP(6) 20779097 37 33 37 10 0 5 13 10 9 0 0.603 1.000 1.000 400 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 EGFR(6), GRB2(2), PTPRB(2), RASA1(2), SHC1(1), SOS1(4), SPRY1(2), SPRY2(1), SPRY4(1), SRC(1) 16100307 22 22 22 8 2 3 14 2 1 0 0.843 1.000 1.000 401 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 30 ADC(3), CAD(6), CPS1(6), EPRS(1), GAD1(1), GAD2(2), GCLM(1), GFPT2(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(1), GMPS(3), GOT1(1), GSR(2), GSS(3), NADSYN1(2), PPAT(2), QARS(2) 25639188 44 39 44 11 4 4 17 10 9 0 0.476 1.000 1.000 402 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 37 ADAM17(1), APH1A(1), CREBBP(11), CTBP2(2), DTX1(1), DTX2(3), DTX3L(4), DTX4(2), DVL3(1), EP300(2), HDAC1(1), HES1(1), JAG1(1), MAML1(1), MAML2(2), MAML3(1), NCOR2(3), NOTCH2(5), NOTCH3(3), NOTCH4(9), NUMB(2), NUMBL(2), PSEN2(2), PSENEN(1), PTCRA(2), RBPJL(2), SNW1(1) 36659652 67 63 67 16 12 8 20 15 12 0 0.210 1.000 1.000 403 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(2), ALPL(2), ALPP(2), ASCC3(5), ATP13A2(2), DDX18(2), DDX23(1), DDX4(3), DDX52(1), DDX54(3), DDX55(1), ENTPD7(1), EP400(3), ERCC2(1), ERCC3(1), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(1), NUDT5(1), PTS(1), QDPR(1), RAD54L(4), RUVBL2(2), SETX(2), SKIV2L2(1), SMARCA2(3), SPR(2) 39333860 53 49 52 10 7 9 20 12 5 0 0.124 1.000 1.000 404 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(2), DARS(2), EPRS(1), FARS2(2), GARS(1), KARS(2), LARS(1), LARS2(2), MARS(3), MARS2(1), QARS(2), RARS(1), SARS(1), TARS(2), WARS(2), WARS2(1), YARS(1) 21653052 28 27 28 9 2 4 13 7 2 0 0.678 1.000 1.000 405 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 93 CASP8(2), CCL4(1), CD40(1), CD80(2), CHUK(1), CXCL9(1), FADD(1), FOS(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(2), IL8(3), IRAK1(3), IRAK4(2), IRF3(2), IRF5(3), LBP(1), LY96(1), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK14(2), MAPK8(1), MAPK9(1), MYD88(1), NFKB1(2), NFKBIA(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), RELA(1), SPP1(1), STAT1(2), TBK1(1), TIRAP(1), TLR1(3), TLR2(1), TLR3(2), TLR4(5), TLR5(3), TLR6(4), TLR7(2), TLR8(4), TLR9(1), TNF(1), TRAF3(1), TRAF6(2) 55379008 106 90 105 22 8 23 31 32 12 0 0.0540 1.000 1.000 406 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(1), DAXX(3), EGFR(6), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(5), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), PPP2CA(2), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF2(1) 31424034 48 46 48 12 7 9 11 8 13 0 0.279 1.000 1.000 407 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CYP2C19(4), CYP2C9(1), DHRS2(1), DHRS7(2), EHHADH(2), HADHA(1), MYST3(5), MYST4(6), SH3GLB1(1), YOD1(3) 20009101 35 33 35 10 0 7 13 11 4 0 0.585 1.000 1.000 408 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 43 ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), CEL(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), GLB1(1), LCT(9), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(2) 29990871 49 44 49 14 3 12 19 10 5 0 0.374 1.000 1.000 409 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 APAF1(2), BIRC3(2), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DFFB(1), FADD(1), IKBKB(2), IRF2(3), IRF3(2), IRF5(3), IRF6(4), LTA(1), MAP2K4(2), MAP3K1(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF21(1), TNFSF10(1), TRAF1(3), TRAF2(1), TRAF3(1) 34754594 55 48 54 13 6 9 16 12 12 0 0.290 1.000 1.000 410 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(2), ATM(8), ATR(3), BAI1(2), CASP8(2), CASP9(2), CCNB3(4), CCNG2(1), CD82(1), CDKN1A(1), CHEK2(3), DDB2(1), EI24(1), GADD45B(1), GTSE1(1), MDM4(1), PERP(1), PTEN(5), RCHY1(1), RFWD2(1), RRM2B(2), SERPINB5(2), SERPINE1(2), SESN1(1), STEAP3(1), THBS1(3), TSC2(3), ZMAT3(2) 38845295 58 50 58 13 10 8 17 15 8 0 0.240 1.000 1.000 411 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BBOX1(1), DLST(1), EHHADH(2), EHMT2(2), GCDH(1), HADHA(1), HSD17B4(1), HSD3B7(1), NSD1(5), OGDH(3), PLOD1(2), PLOD2(1), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SETD1A(6), SETD7(1), SETDB1(3), SHMT1(2), SHMT2(1), SPCS3(1), SUV39H2(1), TMLHE(1) 36854283 59 52 59 14 7 8 21 17 6 0 0.255 1.000 1.000 412 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(2), DAXX(3), DDIT3(2), ELK1(2), GRB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(5), MAP3K7(2), MAP3K9(1), MAPK14(2), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(2), PLA2G4A(1), RPS6KA5(2), SHC1(1), STAT1(2), TGFB2(1), TGFBR1(1), TRAF2(1) 23875560 41 41 41 11 2 9 17 6 7 0 0.472 1.000 1.000 413 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(3), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), AOX1(5), CARM1(3), DBH(2), DCT(3), DDC(2), ECH1(1), GOT1(1), HPD(3), MAOA(2), MAOB(1), MYST3(5), MYST4(6), PRMT2(2), PRMT5(2), PRMT8(2), SH3GLB1(1), TAT(2), TPO(6), TYR(1), TYRP1(1) 37653964 69 60 69 17 8 8 22 22 9 0 0.249 1.000 1.000 414 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 63 AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), CCKBR(2), CCR3(5), CCR6(1), CCR8(2), CXCR3(3), EDNRA(2), EDNRB(1), FPR1(1), FSHR(7), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(2), LHCGR(4), MC2R(4), MC3R(3), MC5R(1), NPY5R(2), OPRD1(1), OPRK1(1), PPYR1(1), SSTR1(1), TACR1(1), TACR3(2), TRHR(1), TSHR(4) 31384270 74 62 73 23 15 5 22 23 9 0 0.421 1.000 1.000 415 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 48 ACTG1(1), APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DAXX(3), DFFB(1), FADD(1), GSN(3), LMNA(3), MAP3K1(2), MAP3K14(1), MAP3K5(5), MAPK8(1), NFKB1(2), NFKBIA(2), NUMA1(3), PAK2(2), PRKDC(7), PSEN2(2), PTK2(2), RASA1(2), RELA(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF1(3), TRAF2(1) 43012842 67 56 67 14 5 17 15 16 14 0 0.147 1.000 1.000 416 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(2), CARS(2), DARS(2), EPRS(1), FARS2(2), FARSA(4), FARSB(1), GARS(1), IARS2(3), KARS(2), LARS(1), LARS2(2), MARS(3), MARS2(1), MTFMT(2), NARS2(2), PARS2(1), QARS(2), RARS(1), RARS2(3), SARS(1), SARS2(1), TARS(2), TARS2(1), VARS(3), VARS2(3), WARS(2), WARS2(1), YARS(1), YARS2(1) 36179757 55 50 55 12 8 6 25 11 5 0 0.228 1.000 1.000 417 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 53 ALG2(3), BFAR(2), BTK(2), CAD(6), CASP8(2), CASP8AP2(1), DAXX(3), EGFR(6), EPHB2(2), FADD(1), IL8(3), MAP2K4(2), MAP3K1(2), MAP3K5(5), MAPK8(1), MAPK8IP1(1), MAPK9(1), MET(4), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PTPN13(5), TPX2(1), TRAF2(1), TUFM(1) 43640883 66 60 66 15 6 15 20 14 11 0 0.172 1.000 1.000 418 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(1), FLNC(4), FSCN3(3), LIMK1(1), MYH2(9), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), ROCK2(2), VASP(1), WASL(1) 28255269 42 38 42 12 5 5 12 13 7 0 0.336 1.000 1.000 419 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 186 ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), ARHGAP5(2), BIRC3(2), BRAF(2), CHAD(1), COL11A1(9), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), COMP(2), CTNNB1(2), DIAPH1(1), DOCK1(1), EGFR(6), ELK1(2), ERBB2(5), FIGF(1), FLNB(5), FLNC(4), FLT1(3), FN1(5), GRB2(2), GRLF1(5), HGF(2), IGF1R(1), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAV(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), KDR(7), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), MAPK8(1), MAPK9(1), MET(4), MYL2(1), MYL7(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDGFC(1), PDGFD(1), PDGFRA(2), PDGFRB(3), PDPK1(1), PGF(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PPP1CB(1), PPP1R12A(2), PRKCA(2), PRKCG(2), PTEN(5), PTK2(2), PXN(2), RAPGEF1(3), RELN(10), RHOA(3), ROCK2(2), SHC1(1), SHC4(2), SOS1(4), SOS2(1), SPP1(1), SRC(1), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TLN2(5), TNC(4), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(4), VAV3(5), VCL(6), VEGFA(1), VWF(6) 229981284 430 256 428 112 47 67 162 91 63 0 0.0582 1.000 1.000 420 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 129 ACTB(1), ACTG1(1), CHAD(1), COL11A1(9), COL11A2(3), COL17A1(6), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), COMP(2), DSC1(6), DSC2(1), DSC3(2), DSG1(2), DSG2(1), DSG3(4), DSG4(5), FN1(5), GJA1(2), GJA10(1), GJA5(1), GJA8(3), GJB3(1), GJB4(2), GJB5(2), GJB6(1), GJC3(1), GJD4(2), INA(1), ITGA6(3), ITGB4(2), KRT1(1), KRT10(3), KRT12(1), KRT13(2), KRT14(1), KRT19(1), KRT2(2), KRT23(1), KRT24(1), KRT25(2), KRT27(2), KRT28(2), KRT3(2), KRT35(1), KRT36(1), KRT4(4), KRT5(1), KRT6A(4), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(4), KRT73(2), KRT76(1), KRT77(1), KRT78(3), KRT79(2), KRT82(1), KRT83(2), KRT85(4), KRT86(1), KRT9(2), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), LMNA(3), NES(6), RELN(10), SPP1(1), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNC(4), TNN(4), TNR(5), TNXB(3), VIM(2), VWF(6) 149735618 332 220 332 91 43 52 124 69 44 0 0.154 1.000 1.000 421 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 194 ABI2(1), ACTN2(7), ACTN3(2), ACTN4(1), APC(11), ARHGEF1(6), ARHGEF4(1), ARHGEF7(3), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), BDKRB1(4), BDKRB2(4), BRAF(2), CHRM2(5), CHRM3(5), CHRM5(2), CYFIP1(7), CYFIP2(1), DIAPH1(1), DIAPH2(5), DIAPH3(2), DOCK1(1), EGFR(6), EZR(1), F2(3), F2R(3), FGD1(5), FGF2(1), FGF23(3), FGF4(1), FGF5(2), FGF6(1), FGF8(1), FGF9(1), FGFR2(1), FGFR4(1), FN1(5), GNA12(1), GRLF1(5), GSN(3), IQGAP1(2), IQGAP2(9), IQGAP3(3), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAD(4), ITGAE(2), ITGAL(6), ITGAM(1), ITGAV(2), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), LIMK1(1), LIMK2(1), MOS(2), MRAS(1), MSN(2), MYH10(2), MYH14(2), MYH9(5), MYL2(1), MYL7(1), MYLK(6), MYLK2(2), NCKAP1(3), NCKAP1L(4), NRAS(4), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDGFRA(2), PDGFRB(3), PFN4(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PPP1CB(1), PPP1R12A(2), PPP1R12B(3), PTK2(2), PXN(2), RHOA(3), ROCK2(2), RRAS(1), SCIN(4), SOS1(4), SOS2(1), SSH1(5), SSH2(1), SSH3(1), TIAM1(4), TIAM2(2), VAV1(3), VAV2(4), VAV3(5), VCL(6), WAS(2), WASF2(1), WASL(1) 172976873 331 220 329 88 38 42 124 88 39 0 0.102 1.000 1.000 422 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 161 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY7(2), ADCY8(2), ADCY9(4), ADORA2B(2), ADRA1A(1), ADRB2(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(6), ATP2B3(1), ATP2B4(4), AVPR1B(3), BDKRB1(4), BDKRB2(4), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1F(3), CACNA1G(2), CACNA1I(1), CACNA1S(7), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CCKBR(2), CD38(2), CHP(1), CHRM2(5), CHRM3(5), CHRM5(2), CHRNA7(2), CYSLTR1(2), DRD1(2), EDNRA(2), EDNRB(1), EGFR(6), ERBB2(5), ERBB3(5), ERBB4(2), F2R(3), GNA11(1), GNA14(2), GNAL(2), GNAQ(1), GNAS(3), GRIN2A(4), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), GRPR(2), HRH1(1), HRH2(1), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), LHCGR(4), MYLK(6), MYLK2(2), NOS1(2), NOS3(2), P2RX1(1), P2RX3(2), PDE1A(1), PDE1B(1), PDE1C(4), PDGFRA(2), PDGFRB(3), PHKA1(5), PHKA2(2), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGFR(3), PTK2B(3), RYR1(11), RYR2(22), RYR3(8), SLC25A4(2), SLC25A5(1), SLC8A1(5), SLC8A3(6), TACR1(1), TACR3(2), TNNC2(1), TRHR(1), TRPC1(3), VDAC2(1), VDAC3(1) 168539726 359 218 355 88 50 44 138 89 38 0 0.0131 1.000 1.000 423 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 219 ADCYAP1R1(2), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA2B(2), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), C5AR1(2), CALCR(5), CALCRL(4), CCKBR(2), CGA(1), CHRM2(5), CHRM3(5), CHRM5(2), CNR1(1), CNR2(1), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(2), DRD3(1), EDNRA(2), EDNRB(1), F2(3), F2R(3), F2RL2(1), FPR1(1), FSHB(1), FSHR(7), GABBR1(3), GABBR2(3), GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), GABRB1(3), GABRB3(2), GABRE(5), GABRG1(1), GABRG2(4), GABRQ(2), GABRR2(1), GH1(1), GHRHR(2), GHSR(2), GIPR(1), GLRA1(1), GLRA2(1), GLRA3(3), GNRHR(1), GPR156(1), GPR50(3), GRIA1(1), GRIA2(6), GRIA3(4), GRIA4(3), GRID1(5), GRID2(4), GRIK1(2), GRIK2(4), GRIK3(2), GRIK4(2), GRIK5(1), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), GRIN3A(4), GRM1(4), GRM3(2), GRM4(2), GRM5(2), GRM6(4), GRM7(4), GRM8(5), GRPR(2), GZMA(2), HCRTR1(1), HCRTR2(2), HRH1(1), HRH2(1), HRH4(2), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), LEPR(5), LHCGR(4), MAS1(1), MC2R(4), MC3R(3), MC5R(1), MCHR2(2), MTNR1A(1), MTNR1B(1), NMUR2(3), NPBWR1(1), NPFFR2(2), NPY5R(2), NR3C1(2), OPRD1(1), OPRK1(1), P2RX1(1), P2RX3(2), P2RY1(1), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(2), P2RY6(1), PARD3(1), PPYR1(1), PRLHR(1), PRLR(2), PRSS3(1), PTGDR(1), PTGFR(3), PTH2R(2), SCTR(1), SSTR1(1), TAAR1(1), TAAR6(2), TAAR9(1), TACR1(1), TACR3(2), TRHR(1), TRPV1(1), TSHB(1), TSHR(4), VIPR2(1) 134928353 328 207 326 102 64 30 107 91 36 0 0.246 1.000 1.000 424 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 81 CD36(2), CD47(1), CHAD(1), COL11A1(9), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), DAG1(3), FN1(5), FNDC1(2), FNDC3A(2), FNDC5(1), GP6(1), HMMR(1), HSPG2(6), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAV(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), RELN(10), SDC1(4), SDC2(2), SPP1(1), SV2A(3), SV2B(3), SV2C(2), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNC(4), TNN(4), TNR(5), TNXB(3), VWF(6) 137149719 283 192 283 77 43 44 108 56 32 0 0.140 1.000 1.000 425 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 231 ACVR1B(1), ACVR1C(2), ARRB2(1), ATF2(2), BRAF(2), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1F(3), CACNA1G(2), CACNA1I(1), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB1(2), CACNB2(1), CACNB4(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG6(3), CACNG7(1), CDC25B(2), CHP(1), CHUK(1), DAXX(3), DDIT3(2), DUSP1(1), DUSP7(1), DUSP9(2), ECSIT(2), EGFR(6), ELK1(2), FGF2(1), FGF23(3), FGF4(1), FGF5(2), FGF6(1), FGF8(1), FGF9(1), FGFR2(1), FGFR4(1), FLNB(5), FLNC(4), FOS(1), GADD45B(1), GNA12(1), GRB2(2), IKBKB(2), IL1R2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K14(1), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K6(1), MAP3K7(2), MAP4K1(2), MAP4K3(4), MAP4K4(1), MAPK14(2), MAPK7(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK5(1), MEF2C(1), MKNK1(2), MOS(2), MRAS(1), NFATC2(3), NFATC4(2), NFKB1(2), NLK(1), NRAS(4), NTRK1(2), NTRK2(2), PAK1(1), PAK2(2), PDGFRA(2), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN5(4), PTPRR(3), RAPGEF2(2), RASA1(2), RASA2(2), RASGRF1(6), RASGRF2(5), RASGRP1(1), RASGRP3(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(2), RRAS(1), SOS1(4), SOS2(1), SRF(1), STK4(1), TAOK1(3), TAOK2(1), TGFB2(1), TGFBR1(1), TGFBR2(3), TNF(1), TNFRSF1A(2), TRAF2(1), TRAF6(2) 171114534 270 191 269 77 41 34 102 57 36 0 0.220 1.000 1.000 426 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), AMOTL1(2), ASH1L(3), CASK(4), CGN(2), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CSDA(1), CSNK2A1(2), CTNNA1(3), CTNNA3(5), CTNNB1(2), CTTN(1), EPB41(3), EPB41L2(1), EPB41L3(7), EXOC3(1), EXOC4(5), F11R(2), GNAI2(1), GNAI3(1), INADL(3), JAM3(1), LLGL1(1), LLGL2(5), MAGI1(1), MAGI2(4), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(1), MRAS(1), MYH1(15), MYH10(2), MYH11(5), MYH13(7), MYH14(2), MYH15(5), MYH2(9), MYH3(4), MYH4(13), MYH6(1), MYH7(5), MYH7B(3), MYH8(7), MYH9(5), MYL2(1), MYL7(1), NRAS(4), PARD3(1), PARD6A(1), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PPP2R3A(3), PPP2R4(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PTEN(5), RAB3B(1), RHOA(3), RRAS(1), SPTAN1(4), SRC(1), TJP1(3), TJP2(1), TJP3(2), YES1(1) 122104292 234 173 232 56 35 21 76 62 40 0 0.0821 1.000 1.000 427 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ADRA1A(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP1A4(4), ATP1B1(1), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(6), ATP2B3(1), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1S(7), CACNB1(2), CALM2(1), CALM3(1), CALR(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CASQ2(1), CHRM2(5), CHRM3(5), CHRM5(2), GJA1(2), GJA5(1), GJB3(1), GJB4(2), GJB5(2), GJB6(1), GNA11(1), GNAI2(1), GNAI3(1), GNAQ(1), GNB2(2), GNB4(1), GRK5(1), GRK6(1), ITPR1(4), ITPR2(7), ITPR3(5), MIB1(4), PLCB3(2), PRKACA(1), PRKACB(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RGS1(2), RGS18(2), RGS20(1), RGS4(3), RGS7(6), RGS9(3), RYR1(11), RYR2(22), RYR3(8), SLC8A1(5), SLC8A3(6), YWHAB(1) 120731608 238 167 237 70 44 23 89 56 26 0 0.276 1.000 1.000 428 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 121 ABL1(1), ABLIM1(1), ABLIM2(1), ABLIM3(2), CHP(1), CXCL12(1), DCC(8), DPYSL2(1), DPYSL5(2), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(2), EPHA3(6), EPHA4(1), EPHA6(2), EPHA7(7), EPHB1(4), EPHB2(2), EPHB3(3), EPHB4(1), EPHB6(2), GNAI2(1), GNAI3(1), L1CAM(8), LIMK1(1), LIMK2(1), LRRC4C(2), MET(4), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NGEF(3), NRAS(4), NRP1(3), NTN4(1), NTNG1(3), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PLXNA2(5), PLXNA3(3), PLXNB1(2), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(2), RASA1(2), RHOA(3), RND1(1), ROBO1(7), ROBO2(3), ROBO3(1), ROCK2(2), SEMA3A(4), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3G(2), SEMA4A(1), SEMA4B(2), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA5A(2), SEMA5B(2), SEMA6A(1), SEMA6C(2), SLIT1(5), SLIT2(5), SLIT3(4), SRGAP1(2), SRGAP2(4), UNC5B(3), UNC5C(4), UNC5D(4) 117137107 203 165 201 67 36 31 73 44 18 1 0.554 1.000 1.000 429 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 240 ACVR1(3), ACVR1B(1), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(1), BMPR1B(1), BMPR2(3), CCL15(3), CCL17(1), CCL21(1), CCL28(1), CCL4(1), CCL7(1), CCL8(1), CCR3(5), CCR6(1), CCR8(2), CCR9(2), CD40(1), CNTF(1), CNTFR(1), CSF1(1), CSF1R(2), CSF2RB(2), CSF3(1), CSF3R(2), CXCL12(1), CXCL13(1), CXCL16(1), CXCL9(1), CXCR3(3), EDA(3), EGFR(6), EPOR(2), FLT1(3), FLT3(3), FLT4(1), GH1(1), HGF(2), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNW1(1), IL10(2), IL11RA(1), IL12RB1(1), IL12RB2(2), IL13(1), IL17RA(2), IL17RB(2), IL18R1(2), IL18RAP(2), IL19(1), IL1R2(1), IL20(1), IL20RA(1), IL21R(8), IL23R(1), IL24(2), IL25(1), IL26(2), IL28A(1), IL28RA(1), IL2RA(1), IL2RB(1), IL4R(1), IL5RA(1), IL6R(1), IL6ST(1), IL7R(4), IL8(3), INHBA(3), KDR(7), KIT(8), KITLG(1), LEPR(5), LIFR(2), LTA(1), LTBR(1), MET(4), MPL(1), NGFR(2), OSMR(2), PDGFC(1), PDGFRA(2), PDGFRB(3), PPBP(2), PRLR(2), TGFB2(1), TGFBR1(1), TGFBR2(3), TNF(1), TNFRSF10A(2), TNFRSF11A(2), TNFRSF1A(2), TNFRSF21(1), TNFRSF8(2), TNFRSF9(1), TNFSF10(1), TNFSF11(1), TNFSF18(1), TNFSF8(1), TPO(6), VEGFA(1), XCL2(1), XCR1(1) 111888821 205 164 205 47 30 33 55 58 29 0 0.0159 1.000 1.000 430 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ACTA1(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ARRB2(1), ATF1(2), ATF2(2), ATP2A2(1), ATP2A3(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CNN2(1), CORIN(3), CREB3(1), ETS2(1), FOS(1), GABPA(3), GBA2(3), GJA1(2), GNAQ(1), GNB2(2), GNB4(1), GRK5(1), GRK6(1), GUCY1A3(2), IGFBP1(1), IGFBP6(1), ITPR1(4), ITPR2(7), ITPR3(5), MIB1(4), MYL2(1), MYL4(2), MYLK2(2), NFKB1(2), NOS1(2), NOS3(2), PDE4B(1), PDE4D(1), PLCB3(2), PLCG1(2), PLCG2(1), PRKACA(1), PRKACB(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RAMP3(1), RGS1(2), RGS18(2), RGS20(1), RGS4(3), RGS7(6), RGS9(3), RYR1(11), RYR2(22), RYR3(8), SLC8A1(5), TNXB(3), YWHAB(1) 109602898 190 143 189 59 32 21 72 47 18 0 0.521 1.000 1.000 431 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 124 ALCAM(1), CADM1(2), CADM3(2), CD2(3), CD22(3), CD226(1), CD274(1), CD34(1), CD40(1), CD6(1), CD80(2), CD8A(1), CD8B(1), CDH1(2), CDH2(4), CDH3(2), CDH4(3), CDH5(4), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CNTN1(6), CNTN2(1), CNTNAP1(2), CNTNAP2(12), CTLA4(1), F11R(2), GLG1(4), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-G(3), ICAM1(1), ICAM2(1), ICAM3(2), ICOS(1), ITGA4(3), ITGA6(3), ITGA8(6), ITGAL(6), ITGAM(1), ITGAV(2), ITGB2(2), ITGB7(3), JAM3(1), L1CAM(8), MAG(1), MPZ(2), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(1), NFASC(5), NLGN1(2), NLGN3(2), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(5), PECAM1(2), PTPRC(3), PTPRF(5), PTPRM(3), PVRL1(1), SDC1(4), SDC2(2), SELE(2), SELP(3), SIGLEC1(3), VCAM1(1), VCAN(5) 93176845 197 142 197 46 28 33 64 50 22 0 0.0107 1.000 1.000 432 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 149 ADORA2B(2), ADORA3(2), ADRA1A(1), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), CCKBR(2), CCR3(5), CCR6(1), CCR8(2), CCR9(2), CHML(4), CHRM2(5), CHRM3(5), CHRM5(2), CNR1(1), CNR2(1), CXCR3(3), DRD1(2), DRD2(2), DRD3(1), EDNRA(2), EDNRB(1), F2R(3), F2RL2(1), FPR1(1), FSHR(7), GALT(1), GHSR(2), GPR173(1), GPR174(1), GPR3(1), GPR37(2), GPR37L1(1), GPR4(2), GPR50(3), GPR77(1), GPR85(1), GRPR(2), HCRTR1(1), HCRTR2(2), HRH1(1), HRH2(1), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), LHCGR(4), MAS1(1), MC3R(3), MC5R(1), MTNR1A(1), MTNR1B(1), NMUR2(3), NPY5R(2), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OR10A5(1), OR11A1(3), OR12D3(3), OR7A5(1), OR7C1(2), OR8B8(1), P2RY1(1), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(2), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(3), RRH(1), SSTR1(1), SUCNR1(1), TRHR(1) 71160409 177 139 176 54 34 16 64 47 16 0 0.154 1.000 1.000 433 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 138 ADA(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ADK(1), ADSL(1), ADSS(1), ADSSL1(1), AK1(1), AK2(1), AK5(3), AK7(1), ALLC(2), AMPD1(4), AMPD2(4), AMPD3(1), ATIC(2), CANT1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD1(2), ENTPD3(1), ENTPD5(1), GART(3), GDA(2), GMPR2(3), GMPS(3), GUCY1A3(2), GUCY2C(4), GUCY2F(3), ITPA(1), NPR1(3), NPR2(3), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), NUDT5(1), PAPSS1(1), PDE10A(4), PDE11A(3), PDE1A(1), PDE1C(4), PDE2A(4), PDE3B(1), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE6H(1), PDE7A(1), PDE7B(2), PDE8A(1), PFAS(3), PKLR(1), POLA1(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1), PPAT(2), PRPS1L1(2), PRUNE(2), RFC5(1), RRM1(1), RRM2B(2), XDH(2) 105980372 164 135 161 57 26 14 58 44 22 0 0.851 1.000 1.000 434 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 143 CBLB(1), CBLC(2), CNTF(1), CNTFR(1), CREBBP(11), CSF2RB(2), CSF3(1), CSF3R(2), EP300(2), EPOR(2), GH1(1), GRB2(2), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNW1(1), IL10(2), IL11RA(1), IL12RB1(1), IL12RB2(2), IL13(1), IL19(1), IL20(1), IL20RA(1), IL21R(8), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28RA(1), IL2RA(1), IL2RB(1), IL4R(1), IL5RA(1), IL6R(1), IL6ST(1), IL7R(4), IRF9(1), JAK2(1), JAK3(4), LEPR(5), LIFR(2), MPL(1), OSMR(2), PIAS2(3), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PRLR(2), PTPN11(1), SOCS4(1), SOCS5(3), SOS1(4), SOS2(1), SPRED1(1), SPRED2(3), SPRY1(2), SPRY2(1), SPRY4(1), STAM(1), STAM2(1), STAT1(2), STAT2(2), STAT3(1), STAT4(2), STAT5B(3), STAT6(4), TPO(6), TYK2(2) 91297766 155 134 155 44 18 16 52 45 24 0 0.516 1.000 1.000 435 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 136 APC(11), AXIN1(1), AXIN2(2), BTRC(1), CAMK2B(1), CAMK2D(2), CHD8(6), CHP(1), CREBBP(11), CSNK1A1L(1), CSNK1E(1), CSNK2A1(2), CTBP2(2), CTNNB1(2), CUL1(2), CXXC4(1), DAAM1(2), DAAM2(2), DKK1(1), DKK2(3), DVL3(1), EP300(2), FBXW11(1), FZD1(1), FZD3(1), FZD4(1), FZD5(2), FZD7(2), LEF1(1), LRP5(1), LRP6(3), MAP3K7(2), MAPK8(1), MAPK9(1), MMP7(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NLK(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PORCN(3), PPARD(3), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(4), PRICKLE2(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), RHOA(3), ROCK2(2), SENP2(1), SMAD4(1), TBL1X(1), TBL1XR1(2), TCF7L1(1), TCF7L2(2), VANGL2(1), WIF1(2), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1) 97459766 168 129 167 34 26 29 61 29 23 0 0.0138 1.000 1.000 436 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(2), DRD2(2), EGFR(6), GJA1(2), GNA11(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), GRB2(2), GRM1(4), GRM5(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(4), HTR2C(6), ITPR1(4), ITPR2(7), ITPR3(5), MAP3K2(3), MAPK7(2), NPR1(3), NPR2(3), NRAS(4), PDGFC(1), PDGFD(1), PDGFRA(2), PDGFRB(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(3), SOS1(4), SOS2(1), SRC(1), TJP1(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2) 82955574 168 129 165 45 24 23 69 38 14 0 0.162 1.000 1.000 437 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(1), ACTN2(7), ACTN3(2), ACTN4(1), DMD(7), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH3(4), MYH6(1), MYH7(5), MYH8(7), MYL2(1), MYL4(2), MYOM1(4), NEB(9), TMOD1(1), TNNC2(1), TNNT1(1), TPM2(1), TTN(106), VIM(2) 88271212 171 129 170 39 28 18 57 48 19 1 0.149 1.000 1.000 438 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 121 ACACB(8), BRAF(2), CALM2(1), CALM3(1), CBLB(1), CBLC(2), ELK1(2), EXOC7(1), FOXO1(1), G6PC(1), G6PC2(1), GCK(1), GRB2(2), GYS1(1), GYS2(3), IKBKB(2), INPP5D(4), INSR(5), IRS1(3), IRS4(8), LIPE(1), MAPK8(1), MAPK9(1), MKNK1(2), NRAS(4), PCK2(1), PDE3A(3), PDE3B(1), PDPK1(1), PFKM(1), PFKP(2), PHKA1(5), PHKA2(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PKLR(1), PPARGC1A(3), PPP1CB(1), PPP1R3A(10), PPP1R3B(2), PRKAA2(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPRF(5), PYGB(2), PYGM(3), RAPGEF1(3), RHEB(1), RPS6(1), RPS6KB2(1), SHC1(1), SHC4(2), SOCS4(1), SORBS1(1), SOS1(4), SOS2(1), SREBF1(1), TRIP10(2), TSC2(3) 95260388 158 127 157 51 19 19 58 40 22 0 0.754 1.000 1.000 439 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 90 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), CACNA1C(9), CACNA1D(8), CACNA1F(3), CACNA1S(7), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CGA(1), EGFR(6), ELK1(2), FSHB(1), GNA11(1), GNAQ(1), GNAS(3), GNRH2(1), GNRHR(1), GRB2(2), ITPR1(4), ITPR2(7), ITPR3(5), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAPK14(2), MAPK7(2), MAPK8(1), MAPK9(1), MMP2(1), NRAS(4), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLD1(2), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PTK2B(3), SOS1(4), SOS2(1), SRC(1) 80847676 155 127 152 49 17 19 66 35 18 0 0.662 1.000 1.000 440 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 104 ACTN2(7), ACTN3(2), ACTN4(1), ARHGAP5(2), CDH5(4), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CTNNA1(3), CTNNA3(5), CTNNB1(2), CXCL12(1), CYBB(1), EZR(1), F11R(2), GNAI2(1), GNAI3(1), GRLF1(5), ICAM1(1), ITGA4(3), ITGAL(6), ITGAM(1), ITGB2(2), ITK(7), JAM3(1), MAPK14(2), MLLT4(3), MMP2(1), MMP9(1), MSN(2), MYL2(1), MYL7(1), NCF2(6), NCF4(1), NOX3(1), PECAM1(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PRKCA(2), PRKCG(2), PTK2(2), PTK2B(3), PTPN11(1), PXN(2), RAPGEF4(1), RASSF5(1), RHOA(3), RHOH(1), ROCK2(2), VASP(1), VAV1(3), VAV2(4), VAV3(5), VCAM1(1), VCL(6) 76764017 152 126 151 44 16 20 54 40 22 0 0.422 1.000 1.000 441 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 106 ADA(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADK(1), ADSL(1), ADSS(1), AK1(1), AK2(1), AK5(3), ALLC(2), AMPD1(4), AMPD2(4), AMPD3(1), ATIC(2), ATP1B1(1), ATP5A1(1), ATP5C1(1), ATP5G2(1), ATP5G3(1), ATP5J2(1), CANT1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD1(2), GART(3), GDA(2), GMPS(3), GUCY1A3(2), GUCY2C(4), GUCY2F(3), ITPA(1), NPR1(3), NPR2(3), NT5E(2), PAPSS1(1), PDE1A(1), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(4), PDE7B(2), PDE8A(1), PFAS(3), PKLR(1), POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3), POLR2B(4), POLR2C(1), POLR2H(1), PPAT(2), PRPS1L1(2), PRUNE(2), RRM1(1) 81568933 134 113 131 37 21 16 46 31 20 0 0.388 1.000 1.000 442 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(1), ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ATM(8), ATR(3), BUB1(2), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(4), CCNH(1), CDC14A(1), CDC16(2), CDC20(4), CDC23(1), CDC25A(1), CDC25B(2), CDC27(5), CDC6(1), CDC7(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CHEK2(3), CREBBP(11), CUL1(2), DBF4(3), E2F2(2), E2F3(1), EP300(2), ESPL1(3), GADD45B(1), HDAC1(1), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), ORC1L(2), ORC2L(2), PLK1(2), PRKDC(7), RBL1(1), RBL2(3), SKP2(2), SMAD4(1), SMC1A(5), SMC1B(4), TFDP1(3), TGFB2(1), YWHAB(1), YWHAE(2), YWHAG(1) 86003366 126 112 126 30 21 15 40 27 23 0 0.307 1.000 1.000 443 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ASIP(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L4(1), CREBBP(11), CTNNB1(2), DCT(3), DVL3(1), EDNRB(1), EP300(2), FZD1(1), FZD3(1), FZD4(1), FZD5(2), FZD7(2), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), KIT(8), KITLG(1), LEF1(1), MITF(3), NRAS(4), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), POMC(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), TCF7L1(1), TCF7L2(2), TYR(1), TYRP1(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1) 65417815 134 112 130 37 25 21 43 24 21 0 0.170 1.000 1.000 444 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 BRAF(2), CD244(2), CHP(1), FCGR3B(1), GRB2(2), HLA-A(1), HLA-E(2), HLA-G(3), ICAM1(1), ICAM2(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), ITGAL(6), ITGB2(2), KIR2DL1(1), KIR2DL3(3), KIR2DL4(2), KIR3DL1(3), KIR3DL2(1), KLRC1(1), KLRC2(1), KLRC3(1), KLRK1(1), LCK(1), LCP2(1), MICB(2), NCR1(2), NCR2(1), NCR3(2), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NRAS(4), PAK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), SHC1(1), SHC4(2), SOS1(4), SOS2(1), TNF(1), TNFRSF10A(2), TNFSF10(1), VAV1(3), VAV2(4), VAV3(5), ZAP70(1) 70063955 130 109 129 39 13 20 47 34 16 0 0.464 1.000 1.000 445 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 CAPN10(1), CAPN11(1), CAPN3(2), CAPN5(1), CAPN6(2), CAPN7(2), CAPN9(3), DOCK1(1), GRB2(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAD(4), ITGAE(2), ITGAL(6), ITGAM(1), ITGAV(2), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), MAP2K6(1), MAPK6(2), MAPK7(2), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PDPK1(1), PIK3R2(1), PTK2(2), PXN(2), RAPGEF1(3), ROCK2(2), SHC1(1), SORBS1(1), SOS1(4), SRC(1), TNS1(3), VASP(1), VAV2(4), VAV3(5), VCL(6) 84757557 127 108 127 33 15 16 46 34 16 0 0.163 1.000 1.000 446 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(2), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(2), DDX18(2), DDX23(1), DDX4(3), DDX52(1), DDX54(3), DDX55(1), ENPP1(3), ENPP3(3), ENTPD7(1), EP400(3), ERCC2(1), ERCC3(1), G6PC(1), G6PC2(1), GAA(1), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), GYS2(3), HK1(1), HK2(2), HK3(4), IFIH1(3), MGAM(6), MOV10L1(1), NUDT5(1), PYGB(2), PYGM(3), RAD54L(4), RUVBL2(2), SETX(2), SI(10), SKIV2L2(1), SMARCA2(3), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), UXS1(2) 78881653 120 106 117 24 17 14 42 31 16 0 0.0482 1.000 1.000 447 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 CARD11(1), CBLB(1), CBLC(2), CD3E(2), CD3G(1), CD8A(1), CD8B(1), CHP(1), CHUK(1), CTLA4(1), FOS(1), GRB2(2), ICOS(1), IKBKB(2), IL10(2), ITK(7), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(4), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(3), RASGRP1(1), RHOA(3), SOS1(4), SOS2(1), TNF(1), VAV1(3), VAV2(4), VAV3(5), ZAP70(1) 63557365 116 103 115 35 10 17 45 29 15 0 0.625 1.000 1.000 448 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 BRAF(2), C7orf16(1), CACNA1A(5), GNA11(1), GNA12(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), GRIA1(1), GRIA2(6), GRIA3(4), GRID2(4), GRM1(4), GRM5(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1R(1), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), NOS1(2), NOS3(2), NPR1(3), NPR2(3), NRAS(4), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PRKCA(2), PRKCG(2), PRKG1(3), RYR1(11) 70342000 125 103 123 39 16 17 43 33 16 0 0.550 1.000 1.000 449 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(6), ABCA10(3), ABCA12(7), ABCA13(11), ABCA3(7), ABCA4(7), ABCA5(3), ABCA6(3), ABCA8(3), ABCA9(5), ABCB1(5), ABCB10(1), ABCB11(2), ABCB4(6), ABCB5(3), ABCB7(2), ABCB8(1), ABCC1(3), ABCC10(5), ABCC11(3), ABCC12(2), ABCC2(1), ABCC3(1), ABCC4(1), ABCC5(3), ABCC6(3), ABCC8(2), ABCC9(3), ABCD2(3), ABCD3(1), ABCG1(2), ABCG4(2), ABCG8(2), CFTR(2) 73537162 114 102 114 29 21 17 42 26 8 0 0.0653 1.000 1.000 450 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), AKAP1(1), AKAP12(1), AKAP3(2), AKAP4(1), AKAP6(5), AKAP7(1), AKAP8(1), AKAP9(7), ARHGEF1(6), CALM2(1), CALM3(1), GNA11(1), GNA12(1), GNA14(2), GNAI2(1), GNAI3(1), GNAL(2), GNAQ(1), GNB2(2), ITPR1(4), NRAS(4), PALM2(1), PDE1A(1), PDE1B(1), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE7A(1), PDE7B(2), PDE8A(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PRKD1(3), PRKD3(2), RHOA(3), RRAS(1) 75244051 123 100 121 45 20 15 43 30 15 0 0.850 1.000 1.000 451 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 69 CALM2(1), CALM3(1), CDS1(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), IMPA2(1), INPP1(1), INPP4B(2), INPP5B(2), INPP5D(4), INPPL1(1), ITPK1(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), OCRL(1), PI4KB(5), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3C3(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(5), SYNJ1(6) 78085295 121 99 121 36 11 21 44 35 10 0 0.531 1.000 1.000 452 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), ACVR1B(1), ACVR1C(2), CDH1(2), CREBBP(11), CSNK2A1(2), CTNNA1(3), CTNNA3(5), CTNNB1(2), EGFR(6), EP300(2), ERBB2(5), IGF1R(1), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MET(4), MLLT4(3), NLK(1), PARD3(1), PTPRB(2), PTPRF(5), PTPRJ(2), PTPRM(3), PVRL1(1), PVRL4(2), RHOA(3), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(1), SRC(1), SSX2IP(1), TCF7L1(1), TCF7L2(2), TGFBR1(1), TGFBR2(3), TJP1(3), VCL(6), WAS(2), WASF2(1), WASF3(1), WASL(1), YES1(1) 77872726 122 98 120 24 13 16 41 32 20 0 0.0415 1.000 1.000 453 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 103 A4GNT(3), ALG1(3), ALG10(1), ALG10B(4), ALG11(2), ALG2(3), ALG8(2), ALG9(1), B3GNT1(1), B3GNT2(2), B4GALT2(1), B4GALT5(3), B4GALT7(1), CHPF(1), CHST12(1), CHST14(1), CHST2(2), CHSY1(1), DAD1(2), DPAGT1(1), EXT1(1), EXTL3(2), FUT8(1), GALNT1(3), GALNT12(1), GALNT13(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(1), GALNT6(2), GALNT8(1), GALNTL2(1), GALNTL5(1), GANAB(3), GCNT3(2), GCNT4(4), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), MAN1A1(2), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), MGAT5B(2), NDST2(3), NDST4(2), OGT(3), RPN1(2), RPN2(2), ST3GAL2(2), ST3GAL3(3), ST6GALNAC1(1), STT3B(3), UST(2), WBSCR17(1), XYLT1(4), XYLT2(1) 69366755 114 97 114 23 20 15 39 24 16 0 0.0292 1.000 1.000 454 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(3), ASH2L(1), CARM1(3), CTCFL(3), EHMT2(2), EZH1(4), FBXO11(2), HCFC1(3), HSF4(1), JMJD6(1), MEN1(1), MLL(10), MLL2(2), MLL3(13), MLL4(2), MLL5(5), NSD1(5), OGT(3), PAXIP1(2), PPP1CB(1), PRDM2(2), PRDM7(2), PRDM9(6), PRMT1(1), PRMT5(2), PRMT8(2), SATB1(2), SETD1A(6), SETD2(7), SETD7(1), SETD8(1), SETDB1(3), SETDB2(1), SETMAR(1), STK38(3), SUV39H2(1), SUV420H1(2), SUZ12(1), WHSC1(2) 74988679 113 96 113 23 12 10 42 34 15 0 0.103 1.000 1.000 455 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(1), CABIN1(2), CALM2(1), CALM3(1), CAMK2B(1), CAMK4(4), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(11), CSNK2A1(2), CTLA4(1), EGR2(2), EP300(2), FKBP1B(1), FOS(1), GATA3(3), GRLF1(5), GSK3A(1), ICOS(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL2RA(1), IL8(3), ITK(7), MAPK14(2), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKBIB(1), NFKBIE(1), NPPB(3), NUP214(1), OPRD1(1), PAK1(1), PPP3CC(1), PTPRC(3), RELA(1), SLA(1), TNF(1), TRAF2(1), VAV1(3), VAV2(4), VAV3(5) 56939383 109 96 109 30 8 16 34 28 23 0 0.417 1.000 1.000 456 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(3), ADCY8(2), BRAF(2), CACNA1C(9), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CHP(1), CREBBP(11), EP300(2), GNAQ(1), GRIA1(1), GRIA2(6), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), ITPR1(4), ITPR2(7), ITPR3(5), NRAS(4), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PPP1CB(1), PPP1R12A(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), RPS6KA1(1), RPS6KA2(1) 63885273 116 94 114 31 15 16 35 33 17 0 0.301 1.000 1.000 457 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(1), ABL2(1), BRAF(2), CAMK2B(1), CAMK2D(2), CBLB(1), CBLC(2), CDKN1A(1), CDKN1B(1), EGFR(6), ELK1(2), ERBB2(5), ERBB3(5), ERBB4(2), GRB2(2), MAP2K4(2), MAPK8(1), MAPK9(1), NCK2(1), NRAS(4), NRG1(4), NRG2(3), NRG3(1), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PRKCA(2), PRKCG(2), PTK2(2), RPS6KB2(1), SHC1(1), SHC4(2), SOS1(4), SOS2(1), SRC(1), STAT5B(3) 64153673 103 92 101 35 8 19 38 26 12 0 0.706 1.000 1.000 458 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(1), ARHGEF7(3), BRAF(2), CSE1L(1), DOCK1(1), EPHB2(2), GRB2(2), GRB7(1), GRLF1(5), ITGA1(2), ITGA10(3), ITGA2(3), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MRAS(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PIK3CA(3), PIK3CB(5), PKLR(1), PLCG1(2), PLCG2(1), PTEN(5), PTK2(2), ROCK2(2), SHC1(1), SOS1(4), SOS2(1), SRC(1), TLN2(5), VASP(1), WAS(2) 76917454 105 92 105 31 10 12 35 28 20 0 0.468 1.000 1.000 459 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(2), BDKRB1(4), BDKRB2(4), C2(2), C3(1), C3AR1(1), C4BPA(1), C4BPB(1), C5(3), C5AR1(2), C6(4), C7(3), C8A(1), C8B(2), C9(1), CD46(1), CD55(1), CFH(4), CPB2(1), CR1(3), CR2(2), F10(1), F11(1), F13A1(2), F13B(1), F2(3), F2R(3), F3(1), F5(8), F7(1), F8(6), F9(1), FGA(3), FGB(2), KLKB1(1), KNG1(1), MASP1(3), MASP2(3), MBL2(1), PLAU(2), PLAUR(1), PLG(4), PROS1(1), SERPINA5(2), SERPINC1(2), SERPIND1(1), SERPINE1(2), VWF(6) 58881262 107 91 107 27 14 11 43 28 11 0 0.220 1.000 1.000 460 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1(3), ACVR1B(1), ACVR1C(2), ACVR2A(1), ACVR2B(1), ACVRL1(2), AMHR2(1), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMPR1B(1), BMPR2(3), CHRD(2), COMP(2), CREBBP(11), CUL1(2), E2F4(1), E2F5(3), EP300(2), FST(1), INHBA(3), LEFTY1(1), LTBP1(3), NODAL(1), PITX2(1), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), RBL1(1), RBL2(3), RHOA(3), ROCK2(2), RPS6KB2(1), SMAD1(1), SMAD4(1), SMURF1(2), TFDP1(3), TGFB2(1), TGFBR1(1), TGFBR2(3), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNF(1), ZFYVE9(3) 62720319 100 88 100 26 15 11 35 21 18 0 0.362 1.000 1.000 461 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 79 ACVR1(3), ACVR1B(1), ACVRL1(2), BMPR2(3), BUB1(2), CDKL2(1), CDS1(1), CLK4(1), CSNK2A1(2), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), INPP1(1), INPP4B(2), INPPL1(1), ITPKB(4), MAP3K10(3), MOS(2), NEK1(4), NEK3(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(5), PIK3CG(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCG1(2), PLCG2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), PRKG1(3), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), TGFBR1(1) 71943528 106 86 106 41 17 11 39 28 11 0 0.936 1.000 1.000 462 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(1), ATM(8), BUB1(2), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(4), CCNH(1), CDAN1(3), CDC14A(1), CDC20(4), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDH1(2), CDKN1A(1), CHEK2(3), DTX4(2), E2F2(2), E2F3(1), E2F4(1), E2F5(3), EP300(2), ESPL1(3), HDAC1(1), HDAC3(2), HDAC4(1), HDAC5(1), HDAC6(3), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MPEG1(1), MPL(1), ORC1L(2), ORC2L(2), PLK1(2), PRKDC(7), RBL1(1), SKP2(2), SMAD4(1), TBC1D8(4), TFDP1(3) 70674401 98 85 98 25 19 13 27 23 16 0 0.262 1.000 1.000 463 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 49 ADORA3(2), CCKBR(2), CCR3(5), CELSR2(6), CELSR3(6), CHRM2(5), CHRM3(5), CXCR3(3), EDNRA(2), EMR2(2), EMR3(7), F2R(3), FSHR(7), GHRHR(2), GNRHR(1), GPR116(3), GPR132(2), GPR133(2), GPR143(1), GPR55(1), GPR56(1), GPR77(1), GRM1(4), GRPR(2), HRH4(2), LGR6(2), LPHN2(4), LPHN3(6), OR2M4(1), OR8G2(1), P2RY11(1), P2RY13(3), PTGFR(3), TSHR(4), VN1R1(1) 36560689 103 83 102 33 19 12 37 26 9 0 0.442 1.000 1.000 464 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 66 ACACB(8), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(1), CAMKK1(1), CD36(2), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(8), JAK2(1), JAK3(4), LEPR(5), MAPK8(1), MAPK9(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK2(1), POMC(1), PPARA(1), PPARGC1A(3), PRKAA2(2), PRKAB2(1), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(1), RELA(1), RXRA(2), RXRB(2), RXRG(1), SLC2A1(2), STAT3(1), TNF(1), TNFRSF1A(2), TRAF2(1), TYK2(2) 52144295 93 82 93 22 15 18 23 21 16 0 0.0808 1.000 1.000 465 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 80 ATF2(2), BRAF(2), CHUK(1), DAXX(3), ELK1(2), FOS(1), GRB2(2), IKBKB(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K14(1), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K6(1), MAP3K7(2), MAP3K9(1), MAP4K1(2), MAP4K3(4), MAP4K4(1), MAPK14(2), MAPK6(2), MAPK7(2), MAPK8(1), MAPK9(1), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(2), PAK1(1), PAK2(2), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(2), RPS6KB2(1), SHC1(1), STAT1(2), TGFB2(1), TGFBR1(1), TRAF2(1) 59692950 85 80 85 23 10 15 30 18 12 0 0.407 1.000 1.000 466 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 BTK(2), CARD11(1), CD19(2), CD22(3), CD79A(1), CHP(1), CHUK(1), CR2(2), FOS(1), IFITM1(1), IKBKB(2), INPP5D(4), LILRB3(1), LYN(2), MALT1(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(4), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), RASGRP3(2), VAV1(3), VAV2(4), VAV3(5) 45491598 81 74 80 23 8 10 27 25 11 0 0.476 1.000 1.000 467 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(2), APAF1(2), ATM(8), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHP(1), CHUK(1), CSF2RB(2), DFFB(1), FADD(1), IKBKB(2), IRAK1(3), IRAK2(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(2), NFKBIA(2), NTRK1(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RELA(1), TNF(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(1), TRAF2(1) 52068316 81 71 81 26 9 12 29 21 10 0 0.730 1.000 1.000 468 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 69 BTK(2), GAB2(5), GRB2(2), IL13(1), INPP5D(4), LCP2(1), LYN(2), MAP2K4(2), MAP2K6(1), MAPK14(2), MAPK8(1), MAPK9(1), MS4A2(1), NRAS(4), PDK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCG1(2), PLCG2(1), PRKCA(2), PRKCE(1), SOS1(4), SOS2(1), TNF(1), VAV1(3), VAV2(4), VAV3(5) 44364390 77 70 76 26 4 10 30 24 9 0 0.809 1.000 1.000 469 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 BCR(4), BTK(2), CD19(2), CD22(3), CR2(2), DAG1(3), GRB2(2), GSK3A(1), INPP5D(4), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), MAP4K1(2), NFATC1(1), NFATC2(3), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PTPRC(3), SHC1(1), SOS1(4), SOS2(1), VAV1(3) 46415105 70 67 70 24 5 10 31 16 8 0 0.783 1.000 1.000 470 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CD2BP2(2), CDC40(1), CLK4(1), COL2A1(4), CPSF2(2), CPSF3(1), CSTF2T(2), DDIT3(2), DDX1(2), DHX15(1), DHX16(3), DHX8(2), DHX9(3), DICER1(2), METTL3(1), NONO(2), PABPN1(2), PRPF3(1), PRPF4(2), PRPF4B(1), PRPF8(1), PTBP1(1), PTBP2(1), RNGTT(1), RNPS1(1), SF3A1(3), SF3B2(1), SF3B4(4), SF4(2), SFRS16(1), SFRS7(1), SNRPA(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(1), SRPK2(2), SRRM1(3), SUPT5H(3), U2AF2(1), XRN2(2) 67690773 72 66 72 15 10 13 22 14 13 0 0.143 1.000 1.000 471 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 CDKN1B(1), CREB3(1), EBP(2), ERBB4(2), F2RL2(1), GRB2(2), GSK3A(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS4(8), MET(4), NOLC1(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PREX1(6), PTEN(5), PTK2(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1) 47293164 77 66 77 29 11 12 28 15 11 0 0.861 1.000 1.000 472 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 63 ADAM10(1), ADAM17(1), ATP6AP1(3), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), CHUK(1), EGFR(6), F11R(2), IKBKB(2), IL8(3), JAM3(1), LYN(2), MAP2K4(2), MAP3K14(1), MAPK14(2), MAPK8(1), MAPK9(1), MET(4), NFKB1(2), NFKBIA(2), NOD1(1), PAK1(1), PLCG1(2), PLCG2(1), PTPN11(1), PTPRZ1(12), RELA(1), SRC(1), TJP1(3) 44801952 69 64 68 18 8 11 21 18 11 0 0.374 1.000 1.000 473 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 64 CASP9(2), CHP(1), KDR(7), MAPK14(2), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NOS3(2), NRAS(4), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCG1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(2), PRKCG(2), PTGS2(1), PTK2(2), PXN(2), SH2D2A(1), SRC(1), VEGFA(1) 42388925 69 63 68 22 8 13 19 21 8 0 0.523 1.000 1.000 474 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 45 ACOX1(1), CD36(2), CPT1B(5), CREBBP(11), DUSP1(1), EHHADH(2), EP300(2), HSD17B4(1), LPL(1), ME1(2), NCOA1(2), NCOR1(1), NCOR2(3), NFKBIA(2), NR1H3(5), NR2F1(2), NRIP1(2), PIK3CA(3), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PTGS2(1), RELA(1), RXRA(2), STAT5B(3), TNF(1) 37447744 67 63 67 18 4 8 20 15 20 0 0.646 1.000 1.000 475 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ARHGAP1(1), ARHGEF11(3), BTK(2), INPPL1(1), ITPR1(4), ITPR2(7), ITPR3(5), LIMK1(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3CG(3), PIK3R1(2), PITX2(1), PTEN(5), ROCK2(2), SAG(1), WASL(1) 44690193 65 63 65 26 3 11 23 19 9 0 0.892 1.000 1.000 476 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 BRAF(2), DAG1(3), DRD2(2), EGFR(6), EPHB2(2), GRB2(2), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), PIK3CB(5), PITX2(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), RGS20(1), SHC1(1), SOS1(4), SOS2(1), SRC(1), STAT3(1) 37706814 67 62 67 20 5 12 30 15 5 0 0.572 1.000 1.000 477 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CTLA4(1), DAG1(3), EPHB2(2), FBXW7(5), GRB2(2), ITK(7), ITPKB(4), LCK(1), LCP2(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PLCG1(2), PTPRC(3), RASGRP1(1), RASGRP3(2), SOS1(4), SOS2(1), VAV1(3), ZAP70(1) 34871862 66 61 66 20 9 11 31 9 6 0 0.607 1.000 1.000 478 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ABP1(3), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), AOX1(5), CAT(1), CYP1A1(2), CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2J2(1), CYP4F8(1), CYP51A1(1), DDC(2), EHHADH(2), GCDH(1), HAAO(1), HADHA(1), KMO(2), KYNU(1), MAOA(2), MAOB(1), SDS(1), WARS(2), WARS2(1) 35934903 67 61 67 23 4 13 23 18 9 0 0.679 1.000 1.000 479 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(8), CCNA1(2), CCNG2(1), CCNH(1), CDC25A(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CREB3(1), CREB3L1(1), CREB3L4(1), E2F2(2), E2F3(1), E2F4(1), E2F5(3), GBA2(3), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MNAT1(1), MYT1(1), NACA(3), ORC1L(2), ORC2L(2), POLA2(1), POLE(2), POLE2(2), RBL1(1), RPA1(2), RPA2(1), TFDP1(3), TNXB(3) 46814142 62 59 62 22 12 8 20 10 12 0 0.790 1.000 1.000 480 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 IMPA2(1), INPP1(1), INPP4B(2), INPP5B(2), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(1), ITPKB(4), MIOX(1), OCRL(1), PI4KB(5), PIK3C3(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PTEN(5), SYNJ1(6) 45429948 72 59 72 18 5 15 28 20 4 0 0.288 1.000 1.000 481 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 62 CDS1(1), CHKA(1), CRLS1(2), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), ETNK1(1), ETNK2(3), GNPAT(6), GPAM(2), GPD2(2), LYPLA2(1), MYST3(5), MYST4(6), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(2), PTDSS1(1), PTDSS2(1), SH3GLB1(1) 41236102 60 57 60 22 6 8 25 15 6 0 0.858 1.000 1.000 482 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 APC(11), AR(4), BRAF(2), CCL15(3), DAG1(3), EGFR(6), GNA11(1), GNAQ(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), MAPK14(2), PHKA2(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PITX2(1), SRC(1) 34010065 65 57 65 19 4 10 22 20 9 0 0.648 1.000 1.000 483 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(11), AXIN1(1), CSNK1E(1), CTNNB1(2), DVL3(1), FBXW2(1), FZD1(1), FZD3(1), FZD5(2), FZD7(2), LDLR(5), MAPK9(1), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RHOA(3), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3) 35361621 65 57 64 20 12 11 23 10 9 0 0.462 1.000 1.000 484 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 ABP1(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), AOX1(5), CARM1(3), CAT(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), DDC(2), EHHADH(2), GCDH(1), HAAO(1), HADHA(1), HSD17B4(1), KMO(2), KYNU(1), LNX1(1), MAOA(2), MAOB(1), NFX1(2), OGDH(3), PRMT2(2), PRMT5(2), PRMT8(2), TPH2(2), WARS(2), WARS2(1) 39194801 66 56 66 18 6 11 25 17 7 0 0.359 1.000 1.000 485 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), CALM2(1), CALM3(1), CALR(1), CAMK4(4), CREBBP(11), F2(3), FGF2(1), MAPK14(2), MAPK8(1), MEF2C(1), MYH2(9), NFATC1(1), NFATC2(3), NFATC4(2), NPPA(1), PIK3CA(3), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1) 31569744 56 56 56 19 8 7 15 16 10 0 0.770 1.000 1.000 486 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 83 AK3(2), CAD(6), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(2), DPYS(1), ENTPD1(2), ENTPD3(1), ENTPD5(1), ITPA(1), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), POLA1(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1), RFC5(1), RRM1(1), RRM2B(2), TK2(1), TXNRD2(3), UCK2(1), UPB1(2) 52497193 59 55 59 27 12 4 17 18 8 0 0.954 1.000 1.000 487 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1C1(2), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CYP1A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP3A43(1), EPHX1(4), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM4(1), GSTO2(1), MGST2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1) 36881447 64 53 64 18 4 8 27 15 10 0 0.397 1.000 1.000 488 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(4), AR(4), ESR1(1), ESR2(2), HNF4A(2), NR1D2(1), NR1H3(5), NR1I2(1), NR1I3(1), NR2F1(2), NR2F2(1), NR3C1(2), NR4A2(3), NR5A2(1), PGR(1), PPARA(1), PPARD(3), RARA(1), RARB(1), RARG(2), ROR1(5), RORA(1), RORC(3), RXRA(2), RXRB(2), RXRG(1), VDR(1) 26291599 54 51 54 16 12 6 18 11 7 0 0.419 1.000 1.000 489 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 BCR(4), BTK(2), CD19(2), DAG1(3), EPHB2(2), GRB2(2), ITPKB(4), LYN(2), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PLCG2(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(1), VAV1(3) 31963451 52 49 52 19 4 9 26 7 6 0 0.864 1.000 1.000 490 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 BRD4(2), CAP1(1), F2RL2(1), GRB2(2), GSK3A(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS4(8), LNPEP(2), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPYR1(1), PTEN(5), RPS6KA1(1), RPS6KA2(1), SHC1(1), SORBS1(1), SOS1(4), SOS2(1), YWHAB(1), YWHAE(2), YWHAG(1) 37037073 51 48 51 29 5 8 20 7 11 0 0.999 1.000 1.000 491 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(4), BTK(2), CD19(2), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), PDK1(1), PIK3CA(3), PITX2(1), PLCG2(1), PREX1(6), PTEN(5), PTPRC(3), RPS6KA1(1), RPS6KA2(1), SAG(1), VAV1(3) 35806809 52 48 52 17 2 7 21 14 8 0 0.783 1.000 1.000 492 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 BRAF(2), CPEB1(1), EGFR(6), ERBB2(5), ERBB4(2), ETS1(1), ETS2(1), ETV6(1), ETV7(1), FMN2(2), GRB2(2), NOTCH2(5), NOTCH3(3), NOTCH4(9), PIWIL1(2), PIWIL2(1), PIWIL3(3), SOS1(4), SOS2(1), SPIRE1(2) 30470592 54 47 53 16 4 8 31 7 4 0 0.668 1.000 1.000 493 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(2), BCL2L2(1), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CD40(1), DAXX(3), DFFB(1), FADD(1), IKBKE(2), LTA(1), NFKB1(2), NFKBIA(2), NGFR(2), NR3C1(2), NTRK1(2), PTPN13(5), SFRS2IP(2), TNF(1), TNFRSF1A(2), TRAF1(3), TRAF2(1), TRAF3(1), TRAF6(2) 28423524 50 46 50 15 5 8 17 11 9 0 0.633 1.000 1.000 494 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 45 ACCN1(2), ADCY4(1), ADCY6(1), ADCY8(2), CACNA1A(5), CACNA1B(2), GNAS(3), GNAT3(1), GRM4(2), ITPR3(5), PDE1A(1), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(1), SCNN1A(1), SCNN1B(1), SCNN1G(2), TAS1R1(1), TAS1R2(2), TAS2R16(2), TAS2R42(2), TAS2R43(1), TAS2R46(1), TAS2R50(2), TAS2R8(3), TAS2R9(1) 34321052 50 46 49 15 5 7 18 14 6 0 0.462 1.000 1.000 495 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), EZR(1), LY96(1), NCK2(1), PRKCA(2), RHOA(3), ROCK2(2), TLR4(5), TLR5(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2), WAS(2), WASL(1) 32772810 51 46 51 17 8 7 18 14 4 0 0.598 1.000 1.000 496 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), EZR(1), LY96(1), NCK2(1), PRKCA(2), RHOA(3), ROCK2(2), TLR4(5), TLR5(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2), WAS(2), WASL(1) 32772810 51 46 51 17 8 7 18 14 4 0 0.598 1.000 1.000 497 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 AGPS(1), CDS1(1), CHKA(1), CPT1B(5), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), ETNK1(1), GNPAT(6), GPD2(2), LYPLA2(1), PAFAH2(2), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB2(3), PLCG1(2), PLCG2(1), PPAP2A(2) 30518418 44 44 44 13 4 8 16 12 4 0 0.525 1.000 1.000 498 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 53 AK3(2), CAD(6), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(2), DPYS(1), ENTPD1(2), ITPA(1), NT5E(2), POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3), POLR2B(4), POLR2C(1), POLR2H(1), RRM1(1), TK2(1), UCK2(1), UNG(1), UPB1(2) 36134202 46 44 46 18 8 6 16 10 6 0 0.851 1.000 1.000 499 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 ATF1(2), BRAF(2), CREB3(1), CREBBP(11), DAG1(3), EGR1(2), EGR2(2), ELK1(2), GNAQ(1), MAP1B(1), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), NTRK1(2), OPN1LW(3), PIK3C2G(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PTPN11(1), SHC1(1), SRC(1) 29961760 49 44 49 23 3 5 19 13 9 0 0.984 1.000 1.000 500 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CALM3(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), GRB2(2), LCK(1), MAP2K4(2), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(3), ZAP70(1) 30425225 49 44 49 18 6 6 22 9 6 0 0.861 1.000 1.000 501 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(6), ARHGEF11(3), ARHGEF5(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), DIAPH1(1), GSN(3), LIMK1(1), MYL2(1), MYLK(6), OPHN1(2), PIP5K1A(1), PPP1R12B(3), SRC(1), VCL(6) 29278267 44 43 44 14 5 8 18 11 2 0 0.578 1.000 1.000 502 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 DAG1(3), DGKA(2), ETFA(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(1), PIK3C2G(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PSME1(2), RIPK3(2), VASP(1) 31282624 46 43 46 19 2 7 17 13 7 0 0.932 1.000 1.000 503 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 ARHGEF11(3), DLG4(1), LPA(7), MAP2K4(2), MAP3K1(2), MAP3K5(5), MAPK8(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(5), PLD1(2), PLD2(2), PTK2(2), ROCK2(2), SERPINA4(3), SRF(1) 30995585 48 43 48 16 8 7 15 8 10 0 0.787 1.000 1.000 504 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 62 ACSS1(1), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), G6PC2(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PGK2(1), PKLR(1) 36491823 44 42 44 15 7 8 15 10 4 0 0.508 1.000 1.000 505 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(1), ELK1(2), FOS(1), GRB2(2), HGF(2), ITGA1(2), MAP4K1(2), MAPK8(1), MET(4), PAK1(1), PIK3CA(3), PIK3R1(2), PTEN(5), PTK2(2), PTK2B(3), PTPN11(1), PXN(2), RASA1(2), SOS1(4), SRC(1), STAT3(1) 28963535 45 42 45 18 3 5 22 5 10 0 0.957 1.000 1.000 506 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 109 ATP12A(3), ATP4A(1), ATP5A1(1), ATP5C1(1), ATP5E(1), ATP5G2(1), ATP5G3(1), ATP5J2(1), ATP5O(1), ATP6AP1(3), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), COX10(1), COX15(1), COX6B1(1), COX8C(1), CYC1(2), NDUFA9(1), NDUFB2(1), NDUFB5(1), NDUFB9(1), NDUFS1(1), NDUFV1(1), NDUFV3(2), PPA2(1), SDHA(1), SDHC(1), UQCRB(1) 35950485 41 41 40 14 8 5 11 11 6 0 0.700 1.000 1.000 507 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 DAG1(3), GNAQ(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(5), PITX2(1), PLD1(2), PLD2(2), VN1R1(1) 27599153 45 40 45 14 3 6 16 12 8 0 0.748 1.000 1.000 508 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(2), CALM2(1), CALM3(1), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP2K4(2), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), PAK2(2), PIK3CA(3), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(1), PPP3CC(1), SHC1(1), SOS1(4), VAV1(3) 27064842 42 39 42 16 4 7 20 8 3 0 0.871 1.000 1.000 509 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP1(1), INPP4B(2), INPPL1(1), ITPKB(4), MIOX(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(5), PIK3CG(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCG1(2), PLCG2(1) 28813963 42 39 42 15 4 8 17 12 1 0 0.767 1.000 1.000 510 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(3), LIMK1(1), MAP3K1(2), MYL2(1), MYLK(6), NCF2(6), PAK1(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLD1(2), PPP1R12B(3), TRIO(6), VAV1(3) 23204181 41 39 41 17 2 2 16 16 5 0 0.959 1.000 1.000 511 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(11), DAG1(3), DLG4(1), EPHB2(2), GNAQ(1), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), PITX2(1), RYR1(11) 29882080 47 39 47 18 5 6 17 16 3 0 0.857 1.000 1.000 512 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 40 ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AMD1(1), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(1), CPS1(6), GATM(1), GLUD1(1), GOT1(1), MAOA(2), MAOB(1), NOS1(2), NOS3(2), ODC1(2), OTC(1), RARS(1) 27048647 41 38 41 18 2 6 12 11 10 0 0.951 1.000 1.000 513 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 90 ANK2(10), B3GALT4(1), DGKI(4), IL6ST(1), PIGK(1), RPL14(1), RPL15(1), RPL22(1), RPL30(1), RPL32(1), RPL8(1), RPLP1(1), RPS10(2), RPS14(1), RPS27A(1), RPS3(1), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), RPS9(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(1), UBC(2) 31856198 41 38 41 18 7 6 11 8 9 0 0.944 1.000 1.000 514 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B4(2), EIF2B5(7), EIF2S1(1), EIF2S2(1), FLT1(3), FLT4(1), KDR(7), NOS3(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(2), PXN(2), SHC1(1) 20807128 38 38 38 13 7 8 8 9 6 0 0.672 1.000 1.000 515 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CALM3(1), ELK1(2), FPR1(1), MAP2K6(1), MAP3K1(2), MAPK14(2), NCF2(6), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(2), PLCB1(6), PPP3CA(1), PPP3CC(1), RELA(1) 24296664 38 37 38 16 6 4 14 11 3 0 0.915 1.000 1.000 516 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PKLR(1) 31611732 39 37 39 16 7 9 13 7 3 0 0.689 1.000 1.000 517 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PKLR(1) 31611732 39 37 39 16 7 9 13 7 3 0 0.689 1.000 1.000 518 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(1), COX10(1), COX15(1), CP(1), EPRS(1), FTH1(1), FTMT(1), GUSB(2), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), UROD(1), UROS(1) 26720642 38 37 38 11 4 6 12 10 6 0 0.533 1.000 1.000 519 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 ANKHD1(1), EEF1D(1), EEF1G(1), EEF2K(1), EIF1AX(1), EIF2AK2(2), EIF2AK3(3), EIF2B4(2), EIF2B5(7), EIF2S1(1), EIF2S2(1), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G3(2), EIF5B(1), ETF1(1), GSPT2(1), KIAA0664(1), PABPC1(1), PABPC3(4), PAIP1(1) 26667583 38 37 38 11 3 3 16 9 7 0 0.679 1.000 1.000 520 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGTR2(2), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), F2(3), GNA11(1), GRB2(2), JAK2(1), MAPK14(2), MAPK8(1), MYLK(6), PLCG1(2), PRKCA(2), PTK2B(3), SHC1(1), SOS1(4), STAT1(2), STAT3(1) 27026196 38 36 38 11 6 5 15 10 2 0 0.493 1.000 1.000 521 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(4), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP3K1(2), PAPPA(4), RPS6KA1(1), SHC1(1), SOS1(4), VAV1(3), VAV2(4), VAV3(5) 18826526 37 36 37 12 2 3 20 8 4 0 0.827 1.000 1.000 522 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGFR(6), ELK1(2), FOS(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(2), STAT3(1) 24448105 38 35 38 12 3 5 20 6 4 0 0.744 1.000 1.000 523 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACB(8), ACAT1(3), ACAT2(1), ACOT12(1), ACSS1(1), AKR1B1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), DLAT(1), GLO1(1), HAGH(1), LDHA(1), LDHB(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PC(1), PCK2(1), PKLR(1) 30504111 39 35 39 19 5 9 13 8 4 0 0.931 1.000 1.000 524 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(7), ACTN3(2), BCR(4), GRB2(2), ITGA1(2), MAPK8(1), PPP1R12B(3), PTK2(2), PXN(2), SHC1(1), SOS1(4), SRC(1), VCL(6) 29273436 38 35 37 11 5 4 21 4 4 0 0.582 1.000 1.000 525 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 ATF2(2), CALM2(1), CALM3(1), EGFR(6), ELK1(2), GNAQ(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(1), PRKCA(2), PTK2(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1) 22028249 37 34 37 14 2 6 19 4 6 0 0.870 1.000 1.000 526 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(6), ELK1(2), GNAS(3), GRB2(2), IGF1R(1), KLK2(1), MKNK1(2), NGFR(2), PDGFRA(2), PPP2CA(2), PTPRR(3), RPS6KA1(1), RPS6KA5(2), SHC1(1), SOS1(4), SRC(1), STAT3(1) 21136553 36 34 35 17 1 5 19 6 5 0 0.958 1.000 1.000 527 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(2), ADCY9(4), AK1(1), ARF5(2), ARL4D(1), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), ERO1L(2), GNAS(3), PDIA4(1), PLCG1(2), PLCG2(1), PRKCA(2), SEC61A1(1), SEC61A2(1), TRIM23(3) 23821392 36 34 34 15 7 3 10 9 7 0 0.825 1.000 1.000 528 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(2), CALM2(1), CALM3(1), CD79A(1), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP3K1(2), MAPK14(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2), SHC1(1), SOS1(4), VAV1(3) 24425089 37 33 37 13 7 5 15 8 2 0 0.705 1.000 1.000 529 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(3), ACADM(3), ACADSB(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), DPYD(2), DPYS(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), SDS(1), UPB1(2) 19061251 33 33 33 14 2 6 7 9 9 0 0.884 1.000 1.000 530 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(1), AARS2(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(3), ASL(1), ASNS(2), ASPA(1), ASS1(1), CAD(6), CRAT(1), DARS(2), DDO(3), DLAT(1), GAD1(1), GAD2(2), GOT1(1), NARS2(2), PC(1) 23922480 34 33 34 16 5 3 13 8 5 0 0.961 1.000 1.000 531 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), SLC23A2(3), SLC2A1(2), SLC2A3(2) 16229497 34 33 34 12 3 7 12 7 5 0 0.650 1.000 1.000 532 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 CARM1(3), CREBBP(11), EP300(2), ERCC3(1), ESR1(1), GTF2E1(1), HDAC1(1), HDAC3(2), HDAC4(1), HDAC5(1), HDAC6(3), MEF2C(1), NCOR2(3), NRIP1(2), PELP1(1), TBP(1) 25876198 35 32 35 14 2 6 11 5 11 0 0.891 1.000 1.000 533 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACPP(2), ALPI(2), ALPL(2), ALPP(2), CYP1A1(2), CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2J2(1), CYP4F8(1), CYP51A1(1) 18530817 33 32 33 13 4 7 14 6 2 0 0.692 1.000 1.000 534 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 BRAF(2), CAB39(1), FIGF(1), PDPK1(1), PGF(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PRKAA2(2), RHEB(1), RICTOR(1), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), TSC2(3), VEGFA(1) 30700258 36 32 36 21 1 4 9 17 5 0 0.996 1.000 1.000 535 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), CAMK2B(1), CAMK2D(2), GNAS(3), GRB2(2), MAPK14(2), PIK3CA(3), PIK3R1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), RPS6KA1(1), RPS6KA5(2), SOS1(4) 18119931 33 31 32 12 7 4 9 7 6 0 0.795 1.000 1.000 536 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 23 CAD(6), CPS1(6), EPRS(1), GAD1(1), GAD2(2), GCLM(1), GLS(1), GLS2(2), GLUD1(1), GLUL(1), GMPS(3), GOT1(1), GSS(3), NADSYN1(2), PPAT(2), QARS(2) 21640842 35 31 35 11 4 3 13 9 6 0 0.668 1.000 1.000 537 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 42 ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GOT1(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), MDH1(1), MDH2(2), PC(1), PDHX(1), PFKM(1), PFKP(2), PGK1(1), PGK2(1), PKLR(1) 26194647 32 31 32 14 8 4 12 5 3 0 0.813 1.000 1.000 538 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(3), GPRC5B(2), GPRC5C(2), GRM1(4), GRM3(2), GRM4(2), GRM5(2), GRM7(4), GRM8(5) 13332503 32 31 32 11 9 2 13 6 2 0 0.642 1.000 1.000 539 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(1), ACADM(3), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOX1(5), BCAT2(2), EHHADH(2), HADHA(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC2(1), OXCT1(2), PCCA(2), PCCB(1) 28537712 36 31 36 14 1 6 11 11 7 0 0.876 1.000 1.000 540 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(3), ACADM(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), DPYD(2), DPYS(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), UPB1(2) 17530878 31 31 31 12 2 4 7 10 8 0 0.837 1.000 1.000 541 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BDH1(1), DDHD1(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), HMGCS2(1), HSD17B4(1), HSD3B7(1), ILVBL(1), L2HGDH(2), OXCT1(2), PLA1A(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1) 26684335 36 31 36 16 1 6 13 10 6 0 0.925 1.000 1.000 542 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(3), EIF4G3(2), IRS1(3), MAPK14(2), MKNK1(2), PABPC1(1), PDPK1(1), PIK3CA(3), PIK3R1(2), PRKCA(2), PTEN(5) 18195158 31 30 31 18 2 2 11 7 9 0 0.999 1.000 1.000 543 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CALM2(1), CALM3(1), ELK1(2), FOS(1), GNAQ(1), GNAS(3), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2) 21392005 30 30 29 11 8 2 8 7 5 0 0.730 1.000 1.000 544 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(2), STAT3(1) 22481596 34 30 34 13 3 4 17 7 3 0 0.879 1.000 1.000 545 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 GRB2(2), GSK3A(1), IL4R(1), IRS1(3), JAK3(4), MAP4K1(2), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SHC1(1), SOS1(4), SOS2(1), STAT6(4) 22113882 31 30 31 17 3 5 14 5 4 0 0.982 1.000 1.000 546 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 BTK(2), GRB2(2), GSK3A(1), IGFBP1(1), INPP5D(4), PDK1(1), PIK3CA(3), PTEN(5), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), YWHAB(1), YWHAE(2), YWHAG(1) 23347010 31 30 31 15 1 7 15 3 5 0 0.966 1.000 1.000 547 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GRB2(2), INSR(5), IRS1(3), JAK2(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RPS6KA1(1), SHC1(1), SOS1(4), SRF(1), STAT5B(3) 21023180 31 29 31 14 2 3 16 6 4 0 0.947 1.000 1.000 548 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 CABIN1(2), CALM2(1), CALM3(1), HDAC5(1), IGF1R(1), INSR(5), MAP2K6(1), MAPK14(2), MAPK7(2), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(1), NFATC1(1), NFATC2(3), PIK3CA(3), PIK3R1(2), PPP3CA(1), PPP3CC(1) 21006444 31 29 31 17 5 2 12 9 3 0 0.985 1.000 1.000 549 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 27 DUSP1(1), GORASP1(2), MAP2K4(2), MAPK14(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK5(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), TRAF2(1), TRAF3(1), TRAF5(1), TRAF6(2) 17452428 30 29 30 10 5 5 9 6 5 0 0.761 1.000 1.000 550 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 GRB2(2), IL4R(1), INPP5D(4), JAK2(1), JAK3(4), PIK3CA(3), SERPINA4(3), SHC1(1), SOS1(4), SOS2(1), SRC(1), STAT6(4), TYK2(2) 23605763 31 29 31 15 2 6 14 6 3 0 0.936 1.000 1.000 551 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADM(3), ACADS(1), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOX1(5), EHHADH(2), HADHA(1), IVD(1), MCCC2(1), OXCT1(2), PCCA(2), PCCB(1), SDS(1) 23788626 34 29 34 14 1 8 10 9 6 0 0.898 1.000 1.000 552 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACB(8), ACADM(3), ACAT1(3), ACAT2(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), EHHADH(2), HADHA(1), LDHA(1), LDHB(1), PCCA(2), PCCB(1) 26567086 32 28 32 13 3 7 12 6 4 0 0.863 1.000 1.000 553 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), INSR(5), IRS1(3), MAPK8(1), PIK3CA(3), PIK3R1(2), PTPN11(1), RASA1(2), SHC1(1), SOS1(4), SRF(1) 16081531 30 28 30 14 0 4 16 8 2 0 0.968 1.000 1.000 554 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CXCR3(3), EGFR(6), ITGA1(2), MYL2(1), MYLK(6), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTK2(2), PXN(2) 21471244 29 28 29 11 4 2 9 7 7 0 0.807 1.000 1.000 555 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(3), EIF4G3(2), MKNK1(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), PTEN(5), RPS6(1), TSC2(3) 16789905 29 28 29 15 0 2 12 6 9 0 0.994 1.000 1.000 556 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACAT1(3), ACAT2(1), ADH5(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), DLAT(1), GLO1(1), HAGH(1), LDHA(1), LDHB(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PC(1), PKLR(1) 23781816 30 27 30 18 2 8 11 6 3 0 0.986 1.000 1.000 557 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(1), ADSL(1), ADSS(1), AGXT2(3), ASL(1), ASNS(2), ASPA(1), CAD(6), CRAT(1), DARS(2), DDO(3), GAD1(1), GAD2(2), GOT1(1), PC(1) 16407868 27 26 27 12 3 3 10 6 5 0 0.943 1.000 1.000 558 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(1), GSN(3), ITGA1(2), MYL2(1), MYLK(6), PIK3CA(3), PIK3R1(2), PTK2(2), PXN(2), SHC1(1), SRC(1) 24731477 26 26 26 15 2 5 8 6 5 0 0.983 1.000 1.000 559 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(2), CA1(2), CA12(1), CA14(1), CA3(1), CA4(2), CA5A(1), CA6(2), CA9(3), CPS1(6), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(1), HAL(1) 13972218 31 26 31 10 0 6 10 9 6 0 0.671 1.000 1.000 560 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(2), DLG4(1), EPHB2(2), F2(3), F2RL2(1), MAPK7(2), MAPK8(1), MYEF2(1), PLD1(2), PLD2(2), PTK2(2), RASAL1(4), SRC(1), VAV1(3) 17614850 27 26 27 15 4 4 9 5 5 0 0.981 1.000 1.000 561 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(5), GNAQ(1), GNAS(3), LIMK1(1), MYL2(1), PIK3C2G(2), PLCB1(6), PPP1R12B(3), PRKCA(2), PTK2(2), ROCK2(2) 16398616 28 25 27 11 2 3 11 7 5 0 0.879 1.000 1.000 562 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(2), CD3G(1), CD80(2), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(1), ITK(7), LCK(1), PIK3CA(3), PIK3R1(2), PTPN11(1) 8517718 25 25 25 10 0 4 13 5 3 0 0.889 1.000 1.000 563 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 31 ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(6), EPRS(1), GATM(1), GLUD1(1), GLUD2(3), GOT1(1), NOS1(2), NOS3(2), OTC(1), PARS2(1), RARS(1), RARS2(3) 21645723 27 25 27 14 0 3 10 8 6 0 0.982 1.000 1.000 564 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(1), POLB(2), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLG(2), POLI(2), POLK(1), POLM(2), POLQ(3), REV3L(1), RFC5(1) 27381923 25 25 25 12 3 3 11 6 2 0 0.968 1.000 1.000 565 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(7), EIF2S1(1), EIF2S2(1), IGF1R(1), INPPL1(1), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), PTEN(5), RPS6(1) 12780176 25 25 25 10 4 4 8 2 7 0 0.890 1.000 1.000 566 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM2(1), CALM3(1), GNAQ(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK14(2), MAPK8(1), PAK1(1), PLCG1(2), PRKCA(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1) 17912685 26 25 26 10 4 4 12 3 3 0 0.818 1.000 1.000 567 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(2), CREB3(1), DUSP9(2), EEF2K(1), GRB2(2), MKNK1(2), MOS(2), NFKB1(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), TRAF3(1) 19017882 25 25 25 14 1 3 11 6 4 0 0.990 1.000 1.000 568 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IGF1R(1), IRS1(3), MAPK8(1), PIK3CA(3), PIK3R1(2), PTPN11(1), RASA1(2), SHC1(1), SOS1(4), SRF(1) 15741621 26 24 26 12 0 4 14 6 2 0 0.960 1.000 1.000 569 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 FOS(1), GRB2(2), IL2RA(1), IL2RB(1), IRS1(3), JAK3(4), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(4), STAT5B(3) 22500082 25 24 25 15 1 5 12 4 3 0 0.984 1.000 1.000 570 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(2), CA12(1), CA14(1), CA3(1), CA4(2), CA5A(1), CA6(2), CA9(3), CPS1(6), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUL(1), HAL(1) 12570467 28 24 28 10 0 6 9 8 5 0 0.723 1.000 1.000 571 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1C4(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(1), SOAT2(2), SRD5A1(1), SRD5A2(1) 15231497 24 23 24 10 3 6 6 6 3 0 0.788 1.000 1.000 572 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), L2HGDH(2), OXCT1(2), SDS(1) 16962965 26 23 26 12 0 7 8 7 4 0 0.909 1.000 1.000 573 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCL12(1), GNAQ(1), NFKB1(2), PIK3C2G(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(2), PTK2B(3), PXN(2), RELA(1) 17746844 23 23 23 14 4 3 9 3 4 0 0.988 1.000 1.000 574 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 BPNT1(1), GRB2(2), PDK1(1), PIK3CA(3), PIK3CD(2), PTEN(5), PTK2B(3), RBL2(3), SHC1(1), SOS1(4) 12923986 25 23 25 10 1 4 14 3 3 0 0.924 1.000 1.000 575 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(3), ITGAV(2), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLCB1(6), PRKCA(2), PTK2(2), SRC(1) 17620224 23 22 23 13 4 2 9 4 4 0 0.976 1.000 1.000 576 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACADM(3), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), HADHA(1), LDHA(1), LDHB(1), PCCA(2), PCCB(1), SDS(1) 22087867 25 22 25 13 1 7 9 4 4 0 0.974 1.000 1.000 577 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(1), GTF2B(2), GTF2E1(1), GTF2F2(1), GTF2H4(1), MNAT1(1), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3B(1), POLR3E(1), TAF12(1), TAF5(1), TAF6(1), TBP(1) 23046127 22 22 22 13 3 2 6 7 4 0 0.972 1.000 1.000 578 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IL6R(1), IL6ST(1), JAK2(1), JAK3(4), PTPN11(1), SHC1(1), SOS1(4), SRF(1), STAT3(1) 15291163 22 20 22 10 2 3 9 7 1 0 0.891 1.000 1.000 579 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 CDKN1B(1), GRB2(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PTEN(5), PTK2(2), SHC1(1), SOS1(4) 12087214 21 20 21 11 0 5 9 1 6 0 0.983 1.000 1.000 580 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(2), MAPK7(2), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(3), PIK3R1(2), PLCG1(2), RPS6KA1(1), SHC1(1) 12092900 18 18 18 13 3 2 9 3 1 0 0.995 1.000 1.000 581 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 CDKN1A(1), ELK1(2), GRB2(2), NGFR(2), NTRK1(2), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(4) 9685330 19 18 19 13 2 3 12 2 0 0 0.991 1.000 1.000 582 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(2), KLK2(1), NTRK1(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(1), SOS1(4) 10133327 19 18 19 12 3 4 9 1 2 0 0.982 1.000 1.000 583 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 MUSK(4), PIK3CA(3), PIK3R1(2), PTK2(2), PTK2B(3), RAPSN(1), SRC(1), TERT(1) 10081773 17 17 17 10 0 3 10 1 3 0 0.962 1.000 1.000 584 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(2), CHUK(1), ELK1(2), NFKB1(2), PIK3CA(3), PIK3R1(2), RALGDS(1), RELA(1), RHOA(3) 11920548 17 17 17 11 1 3 8 3 2 0 0.986 1.000 1.000 585 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), NCKAP1(3), NTRK1(2), PIR(1), WASF2(1), WASF3(1), WASL(1) 10132944 15 15 15 7 1 3 7 4 0 0 0.889 1.000 1.000 586 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(2), IGF1R(1), IRS1(3), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(4) 12024852 16 15 16 11 0 3 9 2 2 0 0.994 1.000 1.000 587 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 CDKN1A(1), CDKN1B(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3CA(3), PIK3R1(2), RELA(1), TFDP1(3) 11721879 16 15 16 11 2 4 3 2 5 0 0.994 1.000 1.000 588 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(2), FOS(1), GRB2(2), JAK2(1), SHC1(1), SOS1(4), STAT5B(3) 10707081 14 14 14 5 0 2 10 2 0 0 0.784 1.000 1.000 589 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1) 5687318 13 13 13 5 0 2 11 0 0 0 0.835 1.000 1.000 590 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 MAP2K6(1), MAP3K1(2), MAPK14(2), NFKB1(2), PIK3CA(3), PIK3R1(2), RELA(1) 11384050 13 12 13 10 3 2 3 4 1 0 0.994 1.000 1.000 591 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(3), PTGS2(1) 3564865 8 8 8 4 3 1 4 0 0 0 0.797 1.000 1.000 592 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGEF2(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1), KDELR3(2) 10589657 9 8 9 4 0 2 3 4 0 0 0.872 1.000 1.000 593 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FOS(1), MAPK14(2), THBS1(3) 4825034 8 8 8 4 1 0 3 4 0 0 0.915 1.000 1.000 594 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 AKR1A1(2), EHHADH(2), HADHA(1), HSD17B4(1), SIRT5(1) 7527684 7 7 7 5 0 0 5 2 0 0 0.974 1.000 1.000 595 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 9 ANPEP(2), FBL(1), LDHA(1), LDHB(1), MAPK14(2) 5604016 7 7 7 6 1 2 3 1 0 0 0.980 1.000 1.000 596 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 10 ALAS1(1), ALAS2(1), CPO(1), HMBS(1), UROD(1), UROS(1) 5369251 6 6 6 5 2 1 2 1 0 0 0.964 1.000 1.000 597 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B2(1), HSD17B4(1), HSD3B1(2), HSD3B2(1) 5369137 6 6 6 4 0 1 2 3 0 0 0.944 1.000 1.000 598 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), KLK2(1), NGFR(2) 4878141 5 5 5 4 1 1 3 0 0 0 0.935 1.000 1.000 599 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(1), HMBS(1), UROD(1), UROS(1) 5180064 5 5 5 4 2 1 1 1 0 0 0.945 1.000 1.000 600 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB1(1), PSMB4(2), PSMB6(1), PSMB9(1) 5736343 5 5 5 4 0 0 4 1 0 0 0.977 1.000 1.000 601 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), CASP8AP2(1), CASP9(2) 6995611 5 5 5 3 0 1 2 2 0 0 0.916 1.000 1.000 602 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL4R(1), JAK2(1), TYK2(2) 6693265 5 5 5 4 0 1 1 3 0 0 0.947 1.000 1.000 603 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL4R(1), JAK2(1), TYK2(2) 6693265 5 5 5 4 0 1 1 3 0 0 0.947 1.000 1.000 604 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK2(1), PTPRU(1), STAT1(2) 7472520 4 4 4 3 0 0 3 1 0 0 0.942 1.000 1.000 605 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK2(1), STAT1(2) 5455555 3 3 3 4 0 0 2 1 0 0 0.987 1.000 1.000 606 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), SNCAIP(1) 4105802 3 3 3 3 0 0 2 1 0 0 0.970 1.000 1.000 607 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(1), LARS2(2) 6832386 3 3 3 5 0 1 2 0 0 0 0.995 1.000 1.000 608 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHKA(1), SLC18A3(1) 4391316 2 2 2 3 0 0 1 1 0 0 0.970 1.000 1.000 609 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), RDH5(1) 2616108 2 2 2 3 0 2 0 0 0 0 0.958 1.000 1.000 610 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYC(1) 3262376 1 1 1 2 0 0 1 0 0 0 0.989 1.000 1.000 611 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1) 4055727 1 1 1 3 0 0 1 0 0 0 0.996 1.000 1.000 612 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 1054432 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 501211 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 350506 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 1107523 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 1010478 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000