E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.101 -9999.0 0.0 -0.323 62.0 62.0 KLHL20 -0.057 0.078 0.468 1.0 -0.278 16.0 17.0 CYFIP2 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.231 6.0 -0.257 14.0 20.0 ENAH -0.046 0.102 -9999.0 0.0 -0.322 63.0 63.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 23.0 23.0 RAP1A 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CDC42/GTP -0.057 0.051 0.116 25.0 -0.234 2.0 27.0 ABI1/Sra1/Nap1 -0.052 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.047 -9999.0 0.0 -0.142 8.0 8.0 RAPGEF1 -0.045 0.098 0.238 4.0 -0.307 53.0 57.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.113 -9999.0 0.0 -0.322 66.0 66.0 CRK -0.045 0.101 -9999.0 0.0 -0.318 58.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.043 -9999.0 0.0 -0.157 18.0 18.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.164 1.0 1.0 IQGAP1 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.043 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.031 0.102 0.192 1.0 -0.323 52.0 53.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.149 15.0 15.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.131 1.0 1.0 PI3K -0.053 0.054 -9999.0 0.0 -0.203 8.0 8.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.177 18.0 18.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 E-cadherin(dimer)/Ca2+ 0.053 0.042 -9999.0 0.0 -0.132 7.0 7.0 AKT1 -0.012 0.069 0.135 53.0 -9999.0 0.0 53.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 70.0 70.0 RhoA/GDP -0.043 0.08 0.232 6.0 -0.252 17.0 23.0 actin cytoskeleton organization -0.043 0.059 0.405 1.0 -0.223 7.0 8.0 CDC42/GDP -0.042 0.08 0.232 6.0 -0.249 19.0 25.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.057 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 27.0 27.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.045 -9999.0 0.0 -0.142 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.032 -9999.0 0.0 -0.122 7.0 7.0 mol:GDP -0.042 0.085 0.233 6.0 -0.276 20.0 26.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.028 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.045 0.083 0.239 6.0 -0.26 15.0 21.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.005 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.044 0.057 0.092 3.0 -0.13 144.0 147.0 NME1 0.028 0.008 -9999.0 0.0 0.0 42.0 42.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.322 66.0 66.0 regulation of cell-cell adhesion -0.053 0.041 0.083 24.0 -0.207 2.0 26.0 WASF2 -0.03 0.035 0.096 5.0 -0.103 40.0 45.0 Rap1/GTP -0.053 0.058 0.154 23.0 -0.252 2.0 25.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.063 -9999.0 0.0 -0.152 18.0 18.0 CCND1 -0.054 0.07 0.106 3.0 -0.158 144.0 147.0 VAV2 -0.038 0.165 -9999.0 0.0 -0.66 24.0 24.0 RAP1/GDP -0.044 0.067 0.243 4.0 -0.245 4.0 8.0 adherens junction assembly -0.045 0.101 -9999.0 0.0 -0.313 66.0 66.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.009 0.048 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.1 -9999.0 0.0 -0.325 60.0 60.0 PIK3CA 0.021 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.088 0.112 0.553 1.0 -0.394 35.0 36.0 E-cadherin/beta catenin/alpha catenin 0.049 0.03 -9999.0 0.0 -0.146 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.115 -9999.0 0.0 -0.328 66.0 66.0