Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.234 0.279 0.526 82.0 -9999.0 0.0 82.0 KIRREL -0.07 0.198 -9999.0 0.0 -0.694 16.0 16.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.235 0.279 -9999.0 0.0 -0.528 82.0 82.0 PLCG1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 WASL 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.186 0.228 -9999.0 0.0 -0.702 9.0 9.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.147 0.193 -9999.0 0.0 -0.582 9.0 9.0 FYN -0.181 0.216 -9999.0 0.0 -0.381 89.0 89.0 mol:Ca2+ -0.201 0.21 -9999.0 0.0 -0.692 9.0 9.0 mol:DAG -0.186 0.225 -9999.0 0.0 -0.697 9.0 9.0 NPHS2 -0.067 0.169 -9999.0 0.0 -0.684 12.0 12.0 mol:IP3 -0.186 0.225 -9999.0 0.0 -0.697 9.0 9.0 regulation of endocytosis -0.164 0.209 -9999.0 0.0 -0.653 10.0 10.0 Nephrin/NEPH1/podocin/Cholesterol -0.196 0.227 -9999.0 0.0 -0.406 91.0 91.0 establishment of cell polarity -0.234 0.279 -9999.0 0.0 -0.526 82.0 82.0 Nephrin/NEPH1/podocin/NCK1-2 -0.162 0.212 -9999.0 0.0 -0.65 9.0 9.0 Nephrin/NEPH1/beta Arrestin2 -0.165 0.212 -9999.0 0.0 -0.664 10.0 10.0 NPHS1 -0.267 0.335 -9999.0 0.0 -0.677 71.0 71.0 Nephrin/NEPH1/podocin -0.182 0.218 -9999.0 0.0 -0.383 89.0 89.0 TJP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.186 0.228 -9999.0 0.0 -0.702 9.0 9.0 CD2AP 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.186 0.228 -9999.0 0.0 -0.422 55.0 55.0 GRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.179 0.224 -9999.0 0.0 -0.697 12.0 12.0 cytoskeleton organization -0.184 0.241 -9999.0 0.0 -0.725 9.0 9.0 Nephrin/NEPH1 -0.17 0.209 -9999.0 0.0 -0.386 82.0 82.0 Nephrin/NEPH1/ZO-1 -0.181 0.232 -9999.0 0.0 -0.422 82.0 82.0