Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.204 0.317 -9999.0 0.0 -1.079 16.0 16.0 IHH -0.423 0.318 -9999.0 0.0 -0.645 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.108 0.228 -9999.0 0.0 -0.442 52.0 52.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.226 0.439 52.0 -9999.0 0.0 52.0 SMO/beta Arrestin2 -0.148 0.234 -9999.0 0.0 -0.753 16.0 16.0 SMO -0.162 0.243 -9999.0 0.0 -0.763 17.0 17.0 AKT1 -0.052 0.111 -9999.0 0.0 -0.505 3.0 3.0 ARRB2 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 BOC 0.005 0.088 -9999.0 0.0 -0.67 3.0 3.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.16 0.237 -9999.0 0.0 -0.744 17.0 17.0 STIL -0.201 0.25 -9999.0 0.0 -0.6 40.0 40.0 DHH N/PTCH2 -0.072 0.222 -9999.0 0.0 -0.549 30.0 30.0 DHH N/PTCH1 -0.19 0.218 -9999.0 0.0 -0.684 18.0 18.0 PIK3CA 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 DHH -0.03 0.172 -9999.0 0.0 -0.669 12.0 12.0 PTHLH -0.195 0.345 -9999.0 0.0 -1.119 17.0 17.0 determination of left/right symmetry -0.16 0.237 -9999.0 0.0 -0.744 17.0 17.0 PIK3R1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.192 0.335 -9999.0 0.0 -1.09 17.0 17.0 IHH N/Hhip -0.301 0.254 -9999.0 0.0 -0.446 124.0 124.0 DHH N/Hhip -0.061 0.213 -9999.0 0.0 -0.556 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.16 0.237 -9999.0 0.0 -0.744 17.0 17.0 pancreas development -0.053 0.206 -9999.0 0.0 -0.666 18.0 18.0 HHAT 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 PI3K 0.021 0.039 -9999.0 0.0 -0.494 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.057 0.211 -9999.0 0.0 -0.668 19.0 19.0 somite specification -0.16 0.237 -9999.0 0.0 -0.744 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.22 0.264 -9999.0 0.0 -0.634 41.0 41.0 SHH Np/Cholesterol/PTCH2 -0.116 0.219 -9999.0 0.0 -0.417 58.0 58.0 SHH Np/Cholesterol/Megalin -0.125 0.221 -9999.0 0.0 -0.422 59.0 59.0 SHH -0.095 0.219 -9999.0 0.0 -0.49 42.0 42.0 catabolic process -0.195 0.204 -9999.0 0.0 -0.6 18.0 18.0 SMO/Vitamin D3 -0.202 0.274 -9999.0 0.0 -0.626 41.0 41.0 SHH Np/Cholesterol/Hhip -0.107 0.212 -9999.0 0.0 -0.412 55.0 55.0 LRP2 -0.079 0.231 -9999.0 0.0 -0.663 24.0 24.0 receptor-mediated endocytosis -0.213 0.27 -9999.0 0.0 -0.612 42.0 42.0 SHH Np/Cholesterol/BOC -0.073 0.186 -9999.0 0.0 -0.395 43.0 43.0 SHH Np/Cholesterol/CDO -0.069 0.174 -9999.0 0.0 -0.377 43.0 43.0 mesenchymal cell differentiation 0.106 0.211 0.409 55.0 -9999.0 0.0 55.0 mol:Vitamin D3 -0.22 0.266 -9999.0 0.0 -0.636 41.0 41.0 IHH N/PTCH2 -0.312 0.262 -9999.0 0.0 -0.456 125.0 125.0 CDON 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 IHH N/PTCH1 -0.197 0.207 -9999.0 0.0 -0.609 18.0 18.0 Megalin/LRPAP1 -0.047 0.174 -9999.0 0.0 -0.488 24.0 24.0 PTCH2 -0.068 0.226 -9999.0 0.0 -0.67 22.0 22.0 SHH Np/Cholesterol -0.091 0.164 -9999.0 0.0 -0.386 42.0 42.0 PTCH1 -0.196 0.205 -9999.0 0.0 -0.603 18.0 18.0 HHIP -0.053 0.206 -9999.0 0.0 -0.667 18.0 18.0