Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	38.0	1762.0	46.0	-0.791	0.026	1000.0	-1000.0	-0.08	-1000.0
IL23-mediated signaling events	37.0	2254.0	60.0	-0.784	0.018	1000.0	-1000.0	-0.168	-1000.0
HIF-1-alpha transcription factor network	33.0	2546.0	76.0	-0.678	0.025	1000.0	-1000.0	-0.156	-1000.0
Signaling events mediated by the Hedgehog family	28.0	1501.0	52.0	-0.423	0.108	1000.0	-1000.0	-0.055	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	27.0	938.0	34.0	-0.267	0.016	1000.0	-1000.0	-0.06	-1000.0
amb2 Integrin signaling	24.0	2032.0	82.0	-0.281	0.022	1000.0	-1000.0	-0.1	-1000.0
IL4-mediated signaling events	23.0	2174.0	91.0	-0.734	0.539	1000.0	-1000.0	-0.152	-1000.0
TCGA08_retinoblastoma	22.0	176.0	8.0	-0.139	0.068	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	21.0	1994.0	93.0	-0.221	0.105	1000.0	-1000.0	-0.088	-1000.0
Syndecan-4-mediated signaling events	21.0	1415.0	67.0	-0.269	0.039	1000.0	-1000.0	-0.105	-1000.0
IL12-mediated signaling events	20.0	1783.0	87.0	-0.341	0.052	1000.0	-1000.0	-0.151	-1000.0
BCR signaling pathway	20.0	2023.0	99.0	-0.325	0.027	1000.0	-1000.0	-0.116	-1000.0
Calcium signaling in the CD4+ TCR pathway	19.0	618.0	31.0	-0.461	0.016	1000.0	-1000.0	-0.096	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1327.0	68.0	-0.55	0.118	1000.0	-1000.0	-0.148	-1000.0
Syndecan-1-mediated signaling events	18.0	620.0	34.0	-0.24	0.016	1000.0	-1000.0	-0.058	-1000.0
Glypican 1 network	17.0	818.0	48.0	-0.408	0.033	1000.0	-1000.0	-0.047	-1000.0
IL6-mediated signaling events	17.0	1289.0	75.0	-0.322	0.067	1000.0	-1000.0	-0.077	-1000.0
JNK signaling in the CD4+ TCR pathway	16.0	279.0	17.0	-0.113	0.016	1000.0	-1000.0	-0.046	-1000.0
Endothelins	16.0	1623.0	96.0	-0.229	0.041	1000.0	-1000.0	-0.107	-1000.0
p75(NTR)-mediated signaling	15.0	1918.0	125.0	-0.447	0.049	1000.0	-1000.0	-0.119	-1000.0
Glucocorticoid receptor regulatory network	15.0	1779.0	114.0	-0.562	0.181	1000.0	-1000.0	-0.084	-1000.0
a4b1 and a4b7 Integrin signaling	14.0	70.0	5.0	-0.061	0.001	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	14.0	1084.0	76.0	-0.282	0.031	1000.0	-1000.0	-0.092	-1000.0
IGF1 pathway	14.0	801.0	57.0	-0.221	0.033	1000.0	-1000.0	-0.119	-1000.0
Reelin signaling pathway	13.0	729.0	56.0	-0.186	0.029	1000.0	-1000.0	-0.098	-1000.0
Ras signaling in the CD4+ TCR pathway	13.0	237.0	17.0	-0.097	0.027	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Cones	12.0	465.0	38.0	-0.156	0.016	1000.0	-1000.0	-0.063	-1000.0
Osteopontin-mediated events	12.0	480.0	38.0	-0.218	0.016	1000.0	-1000.0	-0.126	-1000.0
TCGA08_p53	12.0	86.0	7.0	-0.102	0.06	1000.0	-1000.0	-0.021	-1000.0
Thromboxane A2 receptor signaling	11.0	1256.0	105.0	-0.173	0.035	1000.0	-1000.0	-0.086	-1000.0
Fc-epsilon receptor I signaling in mast cells	11.0	1108.0	97.0	-0.175	0.034	1000.0	-1000.0	-0.098	-1000.0
Integrins in angiogenesis	11.0	972.0	84.0	-0.219	0.026	1000.0	-1000.0	-0.107	-1000.0
Effects of Botulinum toxin	11.0	299.0	26.0	-0.098	0.016	1000.0	-1000.0	-0.074	-1000.0
IL27-mediated signaling events	11.0	572.0	51.0	-0.164	0.073	1000.0	-1000.0	-0.095	-1000.0
Wnt signaling	11.0	82.0	7.0	-0.118	-0.007	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	11.0	574.0	52.0	-0.228	0.016	1000.0	-1000.0	-0.099	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.026	-1000.0	1000.0	-1000.0	-0.024	-1000.0
FOXM1 transcription factor network	11.0	606.0	51.0	-0.179	0.095	1000.0	-1000.0	-0.181	-1000.0
Syndecan-2-mediated signaling events	10.0	738.0	69.0	-0.201	0.044	1000.0	-1000.0	-0.049	-1000.0
Arf6 signaling events	10.0	666.0	62.0	-0.19	0.02	1000.0	-1000.0	-0.069	-1000.0
Noncanonical Wnt signaling pathway	9.0	247.0	26.0	-0.118	0.016	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	9.0	790.0	81.0	-0.244	0.06	1000.0	-1000.0	-0.109	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	367.0	37.0	-0.172	0.024	1000.0	-1000.0	-0.077	-1000.0
IL1-mediated signaling events	9.0	561.0	62.0	-0.227	0.072	1000.0	-1000.0	-0.117	-1000.0
FAS signaling pathway (CD95)	9.0	425.0	47.0	-0.137	0.021	1000.0	-1000.0	-0.047	-1000.0
EGFR-dependent Endothelin signaling events	9.0	198.0	21.0	-0.173	0.024	1000.0	-1000.0	-0.081	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1187.0	120.0	-0.447	0.066	1000.0	-1000.0	-0.102	-1000.0
ErbB4 signaling events	8.0	610.0	69.0	-0.473	0.159	1000.0	-1000.0	-0.105	-1000.0
Ephrin A  reverse signaling	8.0	60.0	7.0	-0.02	0.005	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	8.0	348.0	39.0	-0.159	0.017	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	450.0	52.0	-0.24	0.038	1000.0	-1000.0	-0.066	-1000.0
LPA receptor mediated events	8.0	911.0	102.0	-0.131	0.04	1000.0	-1000.0	-0.099	-1000.0
Angiopoietin receptor Tie2-mediated signaling	8.0	711.0	88.0	-0.141	0.066	1000.0	-1000.0	-0.131	-1000.0
Regulation of Androgen receptor activity	8.0	566.0	70.0	-0.564	0.059	1000.0	-1000.0	-0.067	-1000.0
Coregulation of Androgen receptor activity	7.0	563.0	76.0	-0.479	0.081	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	431.0	54.0	-0.152	0.032	1000.0	-1000.0	-0.118	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	437.0	61.0	-0.37	0.05	1000.0	-1000.0	-0.086	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	349.0	44.0	-0.274	0.016	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	7.0	363.0	51.0	-0.37	0.046	1000.0	-1000.0	-0.078	-1000.0
Nongenotropic Androgen signaling	7.0	399.0	52.0	-0.041	0.02	1000.0	-1000.0	-0.072	-1000.0
LPA4-mediated signaling events	6.0	81.0	12.0	-0.058	0.021	1000.0	-1000.0	-0.034	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	544.0	85.0	-0.117	0.032	1000.0	-1000.0	-0.091	-1000.0
EPO signaling pathway	6.0	384.0	55.0	-0.137	0.016	1000.0	-1000.0	-0.109	-1000.0
Signaling events regulated by Ret tyrosine kinase	6.0	571.0	82.0	-0.058	0.016	1000.0	-1000.0	-0.098	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	498.0	83.0	-0.549	0.061	1000.0	-1000.0	-0.087	-1000.0
S1P1 pathway	6.0	216.0	36.0	-0.232	0.016	1000.0	-1000.0	-0.063	-1000.0
FoxO family signaling	6.0	411.0	64.0	-0.549	0.119	1000.0	-1000.0	-0.075	-1000.0
Syndecan-3-mediated signaling events	6.0	226.0	35.0	-0.107	0.049	1000.0	-1000.0	-0.059	-1000.0
Regulation of p38-alpha and p38-beta	6.0	331.0	54.0	-0.21	0.042	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events	6.0	481.0	73.0	-0.21	0.036	1000.0	-1000.0	-0.077	-1000.0
Insulin Pathway	6.0	444.0	74.0	-0.234	0.042	1000.0	-1000.0	-0.103	-1000.0
Plasma membrane estrogen receptor signaling	6.0	520.0	86.0	-0.219	0.032	1000.0	-1000.0	-0.11	-1000.0
Rapid glucocorticoid signaling	6.0	123.0	20.0	-0.168	0.016	1000.0	-1000.0	-0.034	-1000.0
Aurora B signaling	6.0	440.0	67.0	-0.149	0.018	1000.0	-1000.0	-0.085	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	141.0	28.0	-0.034	0.03	1000.0	-1000.0	-0.045	-1000.0
Insulin-mediated glucose transport	5.0	172.0	32.0	-0.549	0.037	1000.0	-1000.0	-0.065	-1000.0
mTOR signaling pathway	5.0	270.0	53.0	-0.238	0.046	1000.0	-1000.0	-0.079	-1000.0
Ceramide signaling pathway	5.0	427.0	76.0	-0.219	0.044	1000.0	-1000.0	-0.066	-1000.0
HIF-2-alpha transcription factor network	5.0	222.0	43.0	-0.081	0.031	1000.0	-1000.0	-0.092	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	265.0	45.0	-0.146	0.038	1000.0	-1000.0	-0.107	-1000.0
PDGFR-beta signaling pathway	5.0	500.0	97.0	-0.153	0.063	1000.0	-1000.0	-0.109	-1000.0
S1P4 pathway	5.0	135.0	25.0	-0.034	0.024	1000.0	-1000.0	-0.05	-1000.0
Caspase cascade in apoptosis	4.0	364.0	74.0	-0.146	0.026	1000.0	-1000.0	-0.059	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	653.0	136.0	-0.116	0.064	1000.0	-1000.0	-0.089	-1000.0
PLK1 signaling events	4.0	350.0	85.0	-0.056	0.036	1000.0	-1000.0	-0.043	-1000.0
PDGFR-alpha signaling pathway	4.0	189.0	44.0	-0.12	0.034	1000.0	-1000.0	-0.067	-1000.0
S1P5 pathway	4.0	73.0	17.0	-0.034	0.016	1000.0	-1000.0	-0.048	-1000.0
ceramide signaling pathway	4.0	203.0	49.0	-0.146	0.024	1000.0	-1000.0	-0.072	-1000.0
Retinoic acid receptors-mediated signaling	4.0	264.0	58.0	-0.156	0.033	1000.0	-1000.0	-0.085	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	153.0	36.0	-0.072	0.033	1000.0	-1000.0	-0.096	-1000.0
IL2 signaling events mediated by PI3K	4.0	288.0	58.0	-0.075	0.041	1000.0	-1000.0	-0.089	-1000.0
EPHB forward signaling	4.0	383.0	85.0	-0.069	0.049	1000.0	-1000.0	-0.111	-1000.0
Glypican 2 network	4.0	18.0	4.0	-0.007	0.007	1000.0	-1000.0	-0.032	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	355.0	74.0	-0.219	0.07	1000.0	-1000.0	-0.106	-1000.0
IL2 signaling events mediated by STAT5	4.0	88.0	22.0	-0.089	0.033	1000.0	-1000.0	-0.058	-1000.0
Regulation of Telomerase	4.0	441.0	102.0	-0.203	0.059	1000.0	-1000.0	-0.121	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	136.0	33.0	-0.137	0.047	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	337.0	78.0	-0.139	0.085	1000.0	-1000.0	-0.105	-1000.0
ErbB2/ErbB3 signaling events	3.0	208.0	65.0	-0.033	0.037	1000.0	-1000.0	-0.081	-1000.0
Canonical NF-kappaB pathway	3.0	130.0	39.0	-0.146	0.086	1000.0	-1000.0	-0.104	-1000.0
BARD1 signaling events	3.0	216.0	57.0	-0.036	0.056	1000.0	-1000.0	-0.081	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.003	0.016	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	3.0	143.0	43.0	-0.023	0.026	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	3.0	21.0	7.0	-0.022	0.012	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	3.0	155.0	48.0	-0.021	0.047	1000.0	-1000.0	-0.087	-1000.0
Ephrin B reverse signaling	3.0	162.0	48.0	-0.057	0.02	1000.0	-1000.0	-0.083	-1000.0
S1P3 pathway	3.0	161.0	42.0	-0.032	0.031	1000.0	-1000.0	-0.044	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	187.0	65.0	-0.053	0.066	1000.0	-1000.0	-0.078	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	200.0	68.0	-0.549	0.06	1000.0	-1000.0	-0.058	-1000.0
Nectin adhesion pathway	2.0	167.0	63.0	-0.034	0.055	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by HDAC Class III	2.0	99.0	40.0	-0.026	0.027	1000.0	-1000.0	-0.045	-1000.0
Atypical NF-kappaB pathway	2.0	89.0	31.0	-0.034	0.041	1000.0	-1000.0	-0.048	-1000.0
TCGA08_rtk_signaling	2.0	72.0	26.0	-0.068	0.054	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PRL	2.0	69.0	34.0	-0.041	0.045	1000.0	-1000.0	-0.044	-1000.0
p38 MAPK signaling pathway	2.0	129.0	44.0	-0.103	0.032	1000.0	-1000.0	-0.084	-1000.0
Alternative NF-kappaB pathway	2.0	28.0	13.0	-0.003	0.03	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class II	1.0	121.0	75.0	-0.036	0.041	1000.0	-1000.0	-0.058	-1000.0
Circadian rhythm pathway	1.0	32.0	22.0	-0.014	0.053	1000.0	-1000.0	-0.045	-1000.0
Aurora A signaling	1.0	114.0	60.0	-0.027	0.04	1000.0	-1000.0	-0.053	-1000.0
IFN-gamma pathway	1.0	132.0	68.0	-0.103	0.077	1000.0	-1000.0	-0.107	-1000.0
Signaling events mediated by HDAC Class I	1.0	165.0	104.0	-0.146	0.062	1000.0	-1000.0	-0.084	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	25.0	15.0	-0.0	0.035	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	244.0	125.0	-0.034	0.09	1000.0	-1000.0	-0.106	-1000.0
Arf6 trafficking events	1.0	121.0	71.0	-0.17	0.052	1000.0	-1000.0	-0.084	-1000.0
E-cadherin signaling events	1.0	5.0	5.0	0.012	0.028	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.001	0.056	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	68.0	76.0	-0.014	0.071	1000.0	-1000.0	-0.103	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.042	1000.0	-1000.0	-0.067	-1000.0
VEGFR1 specific signals	0.0	35.0	56.0	-0.014	0.073	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in keratinocytes	0.0	21.0	43.0	-0.051	0.055	1000.0	-1000.0	-0.078	-1000.0
Arf1 pathway	0.0	30.0	54.0	-0.041	0.033	1000.0	-1000.0	-0.043	-1000.0
Total	1092	66766	7203	-24.7615276477	-993.898451243	131000	-131000	-10.1655197717	-131000