Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	39.0	1327.0	34.0	-0.107	0.038	1000.0	-1000.0	-0.023	-1000.0
HIF-1-alpha transcription factor network	35.0	2717.0	76.0	-0.504	0.042	1000.0	-1000.0	-0.093	-1000.0
IL23-mediated signaling events	35.0	2117.0	60.0	-0.779	0.036	1000.0	-1000.0	-0.137	-1000.0
FOXA2 and FOXA3 transcription factor networks	33.0	1543.0	46.0	-0.624	0.043	1000.0	-1000.0	-0.119	-1000.0
Signaling events mediated by the Hedgehog family	23.0	1244.0	52.0	-0.218	0.051	1000.0	-1000.0	-0.023	-1000.0
amb2 Integrin signaling	23.0	1921.0	82.0	-0.184	0.046	1000.0	-1000.0	-0.036	-1000.0
IL12-mediated signaling events	21.0	1878.0	87.0	-0.322	0.042	1000.0	-1000.0	-0.075	-1000.0
IL4-mediated signaling events	21.0	1957.0	91.0	-0.716	0.544	1000.0	-1000.0	-0.174	-1000.0
TCR signaling in naïve CD8+ T cells	20.0	1951.0	93.0	-0.131	0.051	1000.0	-1000.0	-0.041	-1000.0
IGF1 pathway	18.0	1030.0	57.0	-0.087	0.065	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	551.0	31.0	-0.268	0.037	1000.0	-1000.0	-0.043	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1162.0	68.0	-0.36	0.103	1000.0	-1000.0	-0.105	-1000.0
BCR signaling pathway	16.0	1643.0	99.0	-0.18	0.049	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	15.0	1577.0	105.0	-0.143	0.056	1000.0	-1000.0	-0.045	-1000.0
Syndecan-4-mediated signaling events	15.0	1019.0	67.0	-0.124	0.049	1000.0	-1000.0	-0.035	-1000.0
Syndecan-1-mediated signaling events	14.0	501.0	34.0	-0.11	0.037	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	245.0	17.0	-0.089	0.037	1000.0	-1000.0	-0.03	-1000.0
p75(NTR)-mediated signaling	14.0	1778.0	125.0	-0.23	0.095	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	14.0	710.0	48.0	-0.214	0.065	1000.0	-1000.0	-0.018	-1000.0
Endothelins	14.0	1373.0	96.0	-0.141	0.072	1000.0	-1000.0	-0.053	-1000.0
IL6-mediated signaling events	14.0	1080.0	75.0	-0.295	0.053	1000.0	-1000.0	-0.063	-1000.0
Ras signaling in the CD4+ TCR pathway	13.0	228.0	17.0	-0.057	0.059	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PTP1B	12.0	938.0	76.0	-0.157	0.044	1000.0	-1000.0	-0.06	-1000.0
Glucocorticoid receptor regulatory network	12.0	1396.0	114.0	-0.413	0.147	1000.0	-1000.0	-0.066	-1000.0
Reelin signaling pathway	12.0	705.0	56.0	-0.054	0.089	1000.0	-1000.0	-0.034	-1000.0
a4b1 and a4b7 Integrin signaling	11.0	57.0	5.0	-0.004	0.034	1000.0	-1000.0	0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	11.0	1130.0	97.0	-0.067	0.067	1000.0	-1000.0	-0.065	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	419.0	37.0	-0.063	0.06	1000.0	-1000.0	-0.022	-1000.0
TCGA08_p53	11.0	79.0	7.0	-0.041	0.036	1000.0	-1000.0	-0.012	-1000.0
IL27-mediated signaling events	11.0	565.0	51.0	-0.093	0.069	1000.0	-1000.0	-0.064	-1000.0
Wnt signaling	11.0	79.0	7.0	-0.037	0.025	1000.0	-1000.0	-0.016	-1000.0
TCGA08_retinoblastoma	11.0	94.0	8.0	-0.04	0.029	1000.0	-1000.0	-0.001	-1000.0
EGFR-dependent Endothelin signaling events	11.0	235.0	21.0	-0.07	0.051	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Cones	10.0	401.0	38.0	-0.066	0.067	1000.0	-1000.0	-0.012	-1000.0
Osteopontin-mediated events	10.0	398.0	38.0	-0.095	0.045	1000.0	-1000.0	-0.051	-1000.0
Integrins in angiogenesis	10.0	903.0	84.0	-0.089	0.075	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.014	0.014	1000.0	-1000.0	-0.016	-1000.0
Noncanonical Wnt signaling pathway	9.0	245.0	26.0	-0.037	0.036	1000.0	-1000.0	-0.036	-1000.0
Syndecan-2-mediated signaling events	9.0	656.0	69.0	-0.075	0.065	1000.0	-1000.0	-0.046	-1000.0
Arf6 signaling events	9.0	605.0	62.0	-0.082	0.065	1000.0	-1000.0	-0.037	-1000.0
BMP receptor signaling	9.0	732.0	81.0	-0.095	0.08	1000.0	-1000.0	-0.039	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	493.0	52.0	-0.195	0.097	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	9.0	250.0	26.0	-0.028	0.042	1000.0	-1000.0	-0.003	-1000.0
Visual signal transduction: Rods	9.0	516.0	52.0	-0.061	0.053	1000.0	-1000.0	-0.018	-1000.0
FOXM1 transcription factor network	9.0	463.0	51.0	-0.075	0.071	1000.0	-1000.0	-0.133	-1000.0
Coregulation of Androgen receptor activity	8.0	661.0	76.0	-0.449	0.106	1000.0	-1000.0	-0.033	-1000.0
Cellular roles of Anthrax toxin	8.0	332.0	39.0	-0.118	0.036	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	504.0	61.0	-0.185	0.096	1000.0	-1000.0	-0.038	-1000.0
Ceramide signaling pathway	8.0	608.0	76.0	-0.089	0.095	1000.0	-1000.0	-0.029	-1000.0
IL1-mediated signaling events	8.0	536.0	62.0	-0.098	0.082	1000.0	-1000.0	-0.03	-1000.0
Canonical Wnt signaling pathway	8.0	437.0	51.0	-0.185	0.063	1000.0	-1000.0	-0.036	-1000.0
Regulation of p38-alpha and p38-beta	8.0	455.0	54.0	-0.084	0.081	1000.0	-1000.0	-0.044	-1000.0
LPA receptor mediated events	8.0	892.0	102.0	-0.086	0.056	1000.0	-1000.0	-0.053	-1000.0
Plasma membrane estrogen receptor signaling	8.0	703.0	86.0	-0.089	0.062	1000.0	-1000.0	-0.047	-1000.0
Angiopoietin receptor Tie2-mediated signaling	8.0	740.0	88.0	-0.062	0.049	1000.0	-1000.0	-0.076	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	998.0	120.0	-0.23	0.096	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	8.0	572.0	70.0	-0.431	0.045	1000.0	-1000.0	-0.048	-1000.0
EPO signaling pathway	7.0	419.0	55.0	-0.046	0.044	1000.0	-1000.0	-0.038	-1000.0
mTOR signaling pathway	7.0	411.0	53.0	-0.109	0.054	1000.0	-1000.0	-0.031	-1000.0
ceramide signaling pathway	7.0	386.0	49.0	-0.048	0.053	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	7.0	496.0	64.0	-0.297	0.064	1000.0	-1000.0	-0.064	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	318.0	45.0	-0.048	0.092	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	7.0	400.0	52.0	-0.024	0.064	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	6.0	72.0	12.0	-0.032	0.01	1000.0	-1000.0	-0.02	-1000.0
Caspase cascade in apoptosis	6.0	491.0	74.0	-0.131	0.079	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	6.0	433.0	69.0	-0.252	0.064	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	362.0	54.0	-0.054	0.052	1000.0	-1000.0	-0.028	-1000.0
Ephrin A  reverse signaling	6.0	45.0	7.0	0.0	0.035	1000.0	-1000.0	0.0	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	578.0	85.0	-0.042	0.057	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	6.0	206.0	32.0	-0.297	0.065	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	6.0	278.0	43.0	-0.054	0.069	1000.0	-1000.0	-0.052	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	502.0	83.0	-0.297	0.071	1000.0	-1000.0	-0.031	-1000.0
FAS signaling pathway (CD95)	6.0	309.0	47.0	-0.102	0.053	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events	6.0	476.0	73.0	-0.144	0.068	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	6.0	504.0	74.0	-0.1	0.087	1000.0	-1000.0	-0.037	-1000.0
Signaling events regulated by Ret tyrosine kinase	5.0	474.0	82.0	0.0	0.056	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by PI3K	5.0	319.0	58.0	-0.011	0.067	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	262.0	44.0	-0.15	0.037	1000.0	-1000.0	-0.031	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	421.0	74.0	-0.108	0.08	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	5.0	117.0	20.0	-0.073	0.039	1000.0	-1000.0	-0.003	-1000.0
Aurora B signaling	5.0	358.0	67.0	-0.115	0.077	1000.0	-1000.0	-0.035	-1000.0
ErbB2/ErbB3 signaling events	4.0	268.0	65.0	-0.039	0.054	1000.0	-1000.0	-0.047	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	642.0	136.0	-0.25	0.077	1000.0	-1000.0	-0.042	-1000.0
PLK1 signaling events	4.0	410.0	85.0	-0.01	0.065	1000.0	-1000.0	-0.025	-1000.0
S1P5 pathway	4.0	72.0	17.0	-0.016	0.037	1000.0	-1000.0	-0.016	-1000.0
S1P1 pathway	4.0	176.0	36.0	-0.14	0.037	1000.0	-1000.0	-0.056	-1000.0
Retinoic acid receptors-mediated signaling	4.0	248.0	58.0	-0.058	0.072	1000.0	-1000.0	-0.033	-1000.0
Syndecan-3-mediated signaling events	4.0	147.0	35.0	-0.028	0.095	1000.0	-1000.0	-0.029	-1000.0
Glypican 2 network	4.0	18.0	4.0	0.021	0.04	1000.0	-1000.0	0.013	-1000.0
IL2 signaling events mediated by STAT5	4.0	95.0	22.0	-0.031	0.039	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	4.0	462.0	97.0	-0.098	0.1	1000.0	-1000.0	-0.04	-1000.0
S1P4 pathway	4.0	112.0	25.0	-0.0	0.052	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	358.0	78.0	-0.091	0.058	1000.0	-1000.0	-0.051	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	99.0	28.0	-0.0	0.068	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	3.0	168.0	43.0	-0.052	0.063	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	3.0	153.0	44.0	-0.072	0.077	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	248.0	68.0	-0.297	0.077	1000.0	-1000.0	-0.028	-1000.0
Nectin adhesion pathway	3.0	205.0	63.0	0.0	0.088	1000.0	-1000.0	-0.045	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	123.0	36.0	-0.05	0.066	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	3.0	338.0	85.0	-0.028	0.081	1000.0	-1000.0	-0.052	-1000.0
Regulation of Telomerase	3.0	386.0	102.0	-0.095	0.095	1000.0	-1000.0	-0.048	-1000.0
S1P3 pathway	3.0	147.0	42.0	-0.002	0.061	1000.0	-1000.0	-0.029	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	113.0	33.0	-0.048	0.098	1000.0	-1000.0	-0.03	-1000.0
Canonical NF-kappaB pathway	2.0	102.0	39.0	-0.048	0.081	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	2.0	169.0	57.0	-0.065	0.08	1000.0	-1000.0	-0.039	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	185.0	65.0	0.0	0.09	1000.0	-1000.0	-0.041	-1000.0
IFN-gamma pathway	2.0	184.0	68.0	-0.022	0.078	1000.0	-1000.0	-0.052	-1000.0
TRAIL signaling pathway	2.0	123.0	48.0	-0.0	0.087	1000.0	-1000.0	-0.031	-1000.0
Ephrin B reverse signaling	2.0	139.0	48.0	-0.048	0.053	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class I	2.0	287.0	104.0	-0.067	0.09	1000.0	-1000.0	-0.03	-1000.0
Atypical NF-kappaB pathway	2.0	72.0	31.0	-0.0	0.051	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	271.0	125.0	-0.006	0.094	1000.0	-1000.0	-0.038	-1000.0
TCGA08_rtk_signaling	2.0	58.0	26.0	-0.043	0.078	1000.0	-1000.0	-0.008	-1000.0
p38 MAPK signaling pathway	2.0	119.0	44.0	-0.022	0.073	1000.0	-1000.0	-0.022	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	0.016	0.065	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	1.0	94.0	75.0	-0.044	0.093	1000.0	-1000.0	-0.018	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.017	0.037	1000.0	-1000.0	-0.01	-1000.0
Aurora C signaling	1.0	12.0	7.0	0.0	0.052	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by HDAC Class III	1.0	79.0	40.0	-0.065	0.066	1000.0	-1000.0	-0.026	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.001	0.037	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	108.0	76.0	-0.016	0.093	1000.0	-1000.0	-0.051	-1000.0
Arf6 trafficking events	1.0	141.0	71.0	-0.153	0.067	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PRL	1.0	48.0	34.0	-0.035	0.054	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in keratinocytes	1.0	55.0	43.0	-0.027	0.067	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	1.0	5.0	5.0	0.034	0.068	1000.0	-1000.0	0.013	-1000.0
Alternative NF-kappaB pathway	1.0	17.0	13.0	0.0	0.094	1000.0	-1000.0	0.0	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.01	0.078	1000.0	-1000.0	-0.033	-1000.0
Aurora A signaling	0.0	55.0	60.0	-0.0	0.074	1000.0	-1000.0	-0.021	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.075	1000.0	-1000.0	-0.025	-1000.0
VEGFR1 specific signals	0.0	43.0	56.0	-0.009	0.097	1000.0	-1000.0	-0.045	-1000.0
Arf1 pathway	0.0	28.0	54.0	-0.001	0.052	1000.0	-1000.0	-0.016	-1000.0
Total	1033	64459	7203	-14.473917518	8.8599484016	131000	-131000	-4.92991276961	-131000