rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(2), GH1(2), GHR(1), IGF1R(2), PIK3CA(12), PIK3R1(1), SHC1(2), SOD2(1), SOD3(1) 8140334 27 26 25 3 6 6 4 9 2 0 0.0382 0.000609 0.375 2 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(3), CYP2C9(2) 1280663 5 5 5 0 3 1 0 1 0 0 0.247 0.00245 0.755 3 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), BCAR1(1), CDKN1B(5), GRB2(1), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PTK2(2), SHC1(2), SOS1(1) 11641639 31 27 29 3 8 8 2 7 6 0 0.0270 0.00773 1.000 4 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), GH1(2), GHR(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), RELA(2), YWHAH(1) 8894992 24 23 22 3 4 8 3 8 1 0 0.0586 0.00863 1.000 5 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(2), HDC(1), PNMT(1), TPH1(1) 3802340 10 10 10 0 5 1 2 2 0 0 0.0299 0.0246 1.000 6 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(2), PTGS1(2), PTGS2(3) 3380190 8 8 8 1 2 3 0 2 1 0 0.204 0.0292 1.000 7 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(3), GRB2(1), KLK2(1), NTRK1(4), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), SHC1(2), SOS1(1) 9556750 28 24 26 4 8 9 2 7 2 0 0.0549 0.0335 1.000 8 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(3), APC(9), CD14(1), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(2), LY96(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), RELA(2), TLR4(1) 18339151 40 38 38 5 9 9 5 8 9 0 0.00843 0.0410 1.000 9 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(4), CDKN2A(1), MDM2(1), MYC(1), PIK3CA(12), PIK3R1(1), POLR1A(3), POLR1B(2), POLR1C(2), RAC1(1), RB1(2) 12322001 30 24 29 3 5 3 5 11 5 1 0.0453 0.0577 1.000 10 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(5), HADHB(1) 5278494 10 10 10 0 3 1 1 3 2 0 0.0730 0.0670 1.000 11 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(12), PIK3R1(1), PLCB1(3), PLCG1(1), PRKCA(2), VAV1(3) 8109425 25 22 23 4 7 6 2 10 0 0 0.136 0.0752 1.000 12 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), GRB2(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(4), PIK3CA(12), PIK3R1(1), PLCG1(1), RPS6KA1(1), SHC1(2) 11648534 30 26 28 4 11 9 3 6 1 0 0.0192 0.0757 1.000 13 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(5) 3044689 6 6 6 0 2 1 0 2 1 0 0.189 0.0823 1.000 14 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(2), SP1(2), SP3(3) 4218255 10 9 10 2 1 2 1 2 3 1 0.378 0.0858 1.000 15 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(2), LPO(1), MPO(1), MTHFR(2), SHMT1(1), SHMT2(1), TPO(3) 7317140 13 13 13 1 6 4 1 1 1 0 0.0454 0.108 1.000 16 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(2), CDK7(1), CDKN1A(2), NEK1(2) 4360755 8 8 8 0 6 0 0 1 1 0 0.140 0.110 1.000 17 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(1), CDKN1A(2), GRB2(1), NTRK1(4), PIK3CA(12), PIK3CD(4), SHC1(2), SOS1(1) 9847597 30 27 28 6 9 9 2 6 4 0 0.0725 0.113 1.000 18 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(5), HADH(1), HSD17B4(3), SIRT1(2), SIRT2(1) 7448940 13 13 13 2 4 4 0 3 2 0 0.202 0.125 1.000 19 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1) 4172578 7 7 7 0 0 2 1 1 3 0 0.109 0.127 1.000 20 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IL12A(1), IL12B(1) 1888234 4 4 4 1 1 0 0 2 1 0 0.623 0.129 1.000 21 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(2), AASDHPPT(1), AASS(1), KARS(1) 4391860 7 7 7 0 0 0 2 4 1 0 0.211 0.136 1.000 22 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), TSC1(1), TSC2(4) 16914710 31 29 29 3 5 6 2 14 4 0 0.0334 0.139 1.000 23 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(2), NRG2(4), NRG3(3), PRKCA(2) 5690073 11 10 11 1 5 1 1 2 2 0 0.136 0.149 1.000 24 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(2), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 5798250 9 9 9 0 2 2 1 1 3 0 0.0370 0.165 1.000 25 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(2), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 5798250 9 9 9 0 2 2 1 1 3 0 0.0370 0.165 1.000 26 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ7(1) 2511430 4 4 4 1 0 1 2 0 1 0 0.489 0.165 1.000 27 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(3), ERBB3(4), NRG1(5) 6493121 14 13 14 3 2 2 0 8 2 0 0.384 0.173 1.000 28 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADH(1), HADHB(1), HSD17B4(3), MECR(1), PPT2(1) 5324847 8 8 8 0 3 3 0 1 1 0 0.0510 0.182 1.000 29 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(1), AASS(1), KARS(1) 2972496 5 5 5 0 0 0 2 3 0 0 0.261 0.183 1.000 30 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2A(1), ADORA3(2), P2RY1(1), P2RY6(1) 3768644 7 7 7 1 4 1 0 2 0 0 0.213 0.183 1.000 31 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), CYR61(1), EIF4E(1), IL1A(1), JUND(1), NR4A3(1), WDR1(1) 6778226 9 9 9 1 2 1 3 2 1 0 0.208 0.188 1.000 32 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(3), CDKN1A(2), CDKN1B(5), MAPK1(1), PAK1(1), PIK3CA(12), PIK3R1(1), RAC1(1), RAF1(1), RB1(2), RELA(2), TFDP1(1) 12470179 32 28 30 5 6 6 7 6 6 1 0.0991 0.206 1.000 33 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), KERA(2) 2269845 4 4 4 1 0 0 0 3 1 0 0.827 0.207 1.000 34 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(5), SDHB(1) 4923166 7 7 7 0 2 2 0 2 1 0 0.129 0.223 1.000 35 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), LARS(2), LARS2(2), PDHA2(3) 6318199 9 9 9 0 2 2 1 3 1 0 0.0662 0.228 1.000 36 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(3), CDKN1A(2), CPB2(1), HIC1(3), MDM2(1), NFKBIB(1), NQO1(1) 8625865 16 13 15 1 7 3 1 2 3 0 0.0376 0.232 1.000 37 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP5(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(3), PON3(1) 11378759 21 18 20 2 5 2 3 6 5 0 0.0293 0.237 1.000 38 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MYC(1), SP1(2), SP3(3) 3932523 6 6 6 1 0 1 0 3 2 0 0.534 0.246 1.000 39 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL16(3), IL1A(1), IL4(1), IL6(1), IL9(1), TNF(1) 6282456 12 11 12 2 4 2 1 3 2 0 0.183 0.251 1.000 40 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(3) 1143265 4 4 4 2 0 1 0 2 1 0 0.807 0.253 1.000 41 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP19(1), SRP54(2) 4772172 6 6 5 0 0 2 1 1 2 0 0.180 0.264 1.000 42 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), PIK3CA(12), PIK3R1(1), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(2) 11665958 23 22 21 4 3 7 5 7 1 0 0.109 0.272 1.000 43 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(1), IRS1(2), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PRKCA(2) 17264495 31 28 29 4 5 6 2 14 4 0 0.0856 0.277 1.000 44 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), MUSK(3), PIK3CA(12), PIK3R1(1), PTK2(2), YWHAH(1) 10244879 22 19 20 3 5 8 2 7 0 0 0.0431 0.279 1.000 45 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 322142 1 1 1 0 0 0 0 0 1 0 0.607 0.292 1.000 46 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(3) 2463353 4 4 3 0 2 0 0 2 0 0 0.304 0.294 1.000 47 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(2), LPO(1), MPO(1), SHMT1(1), SHMT2(1), TPO(3) 7431587 11 11 11 1 5 3 1 1 1 0 0.0884 0.294 1.000 48 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP5(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), PON1(1) 18492031 37 34 36 5 14 4 5 7 7 0 0.0232 0.296 1.000 49 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(2), AKT1(3), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(3), MAPK1(1), PDGFA(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLCB1(3), PRKCA(2), PTK2(2), RAC1(1), SMPD2(2) 17311642 39 32 37 5 10 10 4 13 2 0 0.0137 0.297 1.000 50 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST3A1(1), XYLT1(5), XYLT2(1) 4088694 9 9 9 1 4 2 0 1 2 0 0.122 0.301 1.000 51 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST3A1(1), XYLT1(5), XYLT2(1) 4088694 9 9 9 1 4 2 0 1 2 0 0.122 0.301 1.000 52 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(3), EXTL1(2), EXTL3(2), GLCE(1), HS3ST3A1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(2), NDST4(5) 12992531 24 22 24 3 5 5 4 7 3 0 0.0379 0.306 1.000 53 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), DPEP1(2), LTC4S(1), PLA2G2A(1), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1) 9440901 13 13 13 1 4 3 0 5 1 0 0.0506 0.322 1.000 54 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRA(1), IL10(1), IL4(1) 2503107 3 3 3 0 3 0 0 0 0 0 0.339 0.339 1.000 55 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS2(1), SULT1E1(2), SUOX(1) 3858135 6 6 6 0 3 1 0 1 1 0 0.208 0.339 1.000 56 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(1), NR3C1(1), PPARG(1), TNF(1) 3662617 5 5 5 1 1 0 1 1 2 0 0.599 0.347 1.000 57 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1), TYMS(1) 11305908 16 16 16 2 3 4 0 6 3 0 0.147 0.348 1.000 58 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 1413334 2 2 2 0 0 0 0 0 2 0 0.475 0.355 1.000 59 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(2) 6445680 11 11 11 2 5 2 1 2 1 0 0.192 0.355 1.000 60 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1), PDE6D(1) 2445738 3 3 3 1 1 1 0 0 1 0 0.727 0.356 1.000 61 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(2), GRB2(1), PRKCA(2), PTPRA(3) 5799749 9 8 9 1 5 2 0 2 0 0 0.148 0.366 1.000 62 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), H6PD(2), PFKL(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), PRPS1L1(3), RBKS(2), TKT(1), TKTL2(2) 15314228 21 21 21 2 4 3 5 4 5 0 0.0277 0.372 1.000 63 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(1), MPO(1), TPO(3) 5254445 7 7 7 1 4 2 0 1 0 0 0.228 0.379 1.000 64 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25B(2), CDK7(1), SHH(2) 5479984 7 7 7 1 4 0 2 1 0 0 0.258 0.392 1.000 65 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF4E(1), GSK3B(1), IGF1R(2), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1) 11897751 23 22 21 4 3 6 3 9 2 0 0.155 0.396 1.000 66 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(2), CDKN1B(5), CDKN2A(1), CFL1(1), MDM2(1) 4804576 10 8 10 2 2 0 0 0 8 0 0.758 0.397 1.000 67 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(2), MTMR6(1), NFS1(1), THTPA(3) 4037756 7 7 7 2 2 0 2 1 2 0 0.518 0.398 1.000 68 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(2) 2053152 3 3 3 1 2 0 0 1 0 0 0.705 0.405 1.000 69 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 968455 1 1 1 0 0 1 0 0 0 0 0.718 0.410 1.000 70 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), HLA-DRA(1), IL4(1), IL6(1) 3372181 4 4 4 1 3 1 0 0 0 0 0.452 0.422 1.000 71 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1E1(2), SUOX(1) 5812377 12 11 12 3 7 1 1 1 2 0 0.314 0.422 1.000 72 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), ARHGEF1(4), F2(1), F2R(1), F2RL3(1), GNA13(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(12), PIK3R1(1), PLCB1(3), PRKCA(2), ROCK1(5) 16267934 38 33 36 6 10 6 6 13 3 0 0.0642 0.423 1.000 73 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1), TYMS(1) 11954096 16 16 16 2 3 4 0 6 3 0 0.148 0.423 1.000 74 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(1) 1647641 2 2 2 0 0 1 0 1 0 0 0.512 0.427 1.000 75 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(3), DPYS(2), ENPP1(2), ENPP3(1), PANK1(2), PANK2(2), PANK3(1) 8794087 14 14 13 3 2 3 3 2 4 0 0.401 0.443 1.000 76 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(3), GRB2(1), IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), YWHAH(1) 11724581 27 24 25 5 7 7 4 8 1 0 0.132 0.444 1.000 77 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10(1), IL10RA(2), IL1A(1), IL6(1), JAK1(3), STAT1(1), STAT3(6), TNF(1) 7684828 17 14 17 4 4 3 2 5 3 0 0.254 0.447 1.000 78 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2) 1330392 2 2 2 0 0 0 0 1 1 0 0.810 0.450 1.000 79 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 PLCB1(3), PRKCA(2), RELA(2) 5186468 7 7 7 0 2 2 1 2 0 0 0.0910 0.453 1.000 80 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), HLA-DRA(1) 1916272 2 2 2 0 2 0 0 0 0 0 0.472 0.463 1.000 81 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(1), CS(2), HAO1(2), MTHFD1(2), MTHFD1L(1) 8082551 9 9 9 0 1 2 3 3 0 0 0.0508 0.475 1.000 82 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2), MEF2D(1), YWHAH(1) 4805920 9 8 9 2 5 1 1 2 0 0 0.331 0.479 1.000 83 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), LEPR(1), PRKAA2(4), PRKAG1(2) 9150437 12 12 12 2 3 1 4 4 0 0 0.253 0.481 1.000 84 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1) 4353432 5 5 5 0 1 0 1 0 3 0 0.192 0.481 1.000 85 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5) 7651023 14 14 13 4 5 1 2 4 2 0 0.468 0.483 1.000 86 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1) 3569775 4 4 4 0 2 0 1 1 0 0 0.223 0.485 1.000 87 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(2), CTH(1), GOT1(1), GOT2(1), LDHAL6A(1), LDHC(1), SULT4A1(1) 7915293 9 9 9 0 4 1 0 2 2 0 0.0917 0.491 1.000 88 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(2), B3GALT5(2), FUT1(1), FUT2(1), FUT3(1) 4556289 7 7 7 2 1 2 1 3 0 0 0.558 0.494 1.000 89 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(2), HSD17B3(1), HSD17B4(3), HSD17B7(1), HSD3B1(1), HSD3B2(1) 5108450 9 9 9 3 2 2 2 0 3 0 0.515 0.494 1.000 90 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(1), GOT2(1), LDHC(1) 4328511 5 5 5 0 2 1 0 1 1 0 0.259 0.497 1.000 91 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), PAK1(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), RAC1(1) 8471486 18 17 17 4 5 3 3 6 1 0 0.389 0.498 1.000 92 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(1) 2141192 2 2 2 0 0 1 0 1 0 0 0.592 0.523 1.000 93 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), H6PD(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), PRPS1L1(3), RBKS(2), TKT(1) 12883723 17 17 17 2 3 2 5 4 3 0 0.0975 0.523 1.000 94 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1) 6372354 7 7 7 1 1 0 1 3 2 0 0.431 0.526 1.000 95 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(1), CS(2), HAO1(2), MTHFD1(2), MTHFD1L(1) 8462618 9 9 9 0 1 2 3 3 0 0 0.0510 0.533 1.000 96 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), CYP1A2(1), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2J2(1), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), RDH12(1) 15076152 22 19 22 3 7 1 2 8 4 0 0.118 0.538 1.000 97 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK12(1), MAPK8IP3(3), MAPKAPK5(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), SYT1(1), TRAF2(4), TRAF5(1) 21179103 39 34 38 5 12 6 2 11 8 0 0.0182 0.539 1.000 98 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(2) 7343587 11 11 11 2 5 2 1 2 1 0 0.179 0.542 1.000 99 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), ILVBL(2), LARS(2), LARS2(2), PDHA2(3), VARS(3), VARS2(2) 11701457 16 14 16 2 3 2 1 7 3 0 0.191 0.550 1.000 100 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(3), PON3(1), RDH12(1) 5673409 9 7 9 1 3 0 2 3 1 0 0.197 0.551 1.000 101 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP5(1), ACPT(3), ENPP1(2), ENPP3(1), RFK(1), TYR(2) 6129908 11 11 10 3 3 1 1 2 4 0 0.529 0.554 1.000 102 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(1) 1493628 1 1 1 0 1 0 0 0 0 0 0.692 0.577 1.000 103 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 BMPR1B(1), CDKN1B(5), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), INHA(1), LHCGR(1), MLH1(1), NCOR1(8), NRIP1(2), PGR(2), PRLR(1), ZP2(1) 18162787 28 24 28 4 4 2 4 3 15 0 0.224 0.596 1.000 104 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCAIP(3), UBE2L3(1) 4063206 6 6 6 2 2 0 0 4 0 0 0.670 0.597 1.000 105 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 DCXR(1), UGDH(2), UGP2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2) 17257888 23 21 23 3 4 1 3 11 4 0 0.132 0.599 1.000 106 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCL(1), HMGCS1(1), HMGCS2(1) 4538012 4 4 4 1 1 1 0 2 0 0 0.671 0.607 1.000 107 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(5), RB1(2), TFDP1(1) 5406279 8 7 8 2 0 0 2 0 5 1 0.773 0.608 1.000 108 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), ITPKB(2) 3808991 4 4 4 0 1 1 0 2 0 0 0.266 0.609 1.000 109 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(3), CHST12(1), CHST3(1), CHSY1(1), DSE(1), UST(1), XYLT1(5), XYLT2(1) 8612267 18 18 18 4 9 2 1 3 3 0 0.183 0.618 1.000 110 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), GOT1(1), GOT2(1), PAH(1) 5233585 5 5 5 0 2 1 0 1 1 0 0.177 0.620 1.000 111 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(5), EP300(5), ESR1(2), MAPK1(1), PELP1(2) 9265685 15 14 15 3 8 0 2 2 3 0 0.253 0.623 1.000 112 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(3), AKT2(1), BPNT1(2), GRB2(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), RBL2(2), SHC1(2), SOS1(1) 12362568 30 28 28 7 10 6 4 7 3 0 0.181 0.627 1.000 113 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSB(2), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2) 17192795 24 22 24 3 6 3 2 7 6 0 0.0490 0.628 1.000 114 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 CDC25A(1), CDC25B(2), MYT1(1), YWHAH(1) 4717609 5 5 5 0 3 1 0 1 0 0 0.181 0.632 1.000 115 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PRKCA(2) 3095589 4 4 4 0 1 1 0 1 1 0 0.297 0.641 1.000 116 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ACAT1(1) 3415256 3 3 2 1 2 0 0 1 0 0 0.674 0.643 1.000 117 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), AKT1(3), DAG1(1), DGKA(1), ETFA(1), ITGA9(3), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NR1I3(2), PAK1(1), PDE3B(1), PIK3C2G(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PSME1(1), RIPK3(1) 30643300 49 46 47 8 11 10 4 13 11 0 0.0468 0.644 1.000 118 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1) 14777545 17 17 17 2 6 2 1 6 2 0 0.160 0.663 1.000 119 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), EGFR(3), IGF1R(2), MYC(1), POLR2A(3), PPP2CA(1), PRKCA(2), RB1(2), TEP1(3), TNKS(4) 17217834 24 21 23 2 5 4 3 9 2 1 0.0216 0.667 1.000 120 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(3), MAFF(1), MAPK1(1), PRKCA(2) 5573124 7 7 7 0 3 1 1 2 0 0 0.0839 0.674 1.000 121 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(2), MARCKS(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SP1(2), SP3(3), SYT1(1) 13226934 17 15 17 1 6 1 1 6 3 0 0.0406 0.675 1.000 122 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 9477292 12 12 12 2 2 2 0 5 3 0 0.403 0.675 1.000 123 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 9477292 12 12 12 2 2 2 0 5 3 0 0.403 0.675 1.000 124 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 9477292 12 12 12 2 2 2 0 5 3 0 0.403 0.675 1.000 125 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), PIK3R4(1), PRKAA2(4), ULK3(1) 13309933 16 16 16 3 5 0 4 5 2 0 0.258 0.682 1.000 126 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGIR(2), TBXA2R(2) 7039962 12 11 12 3 7 3 0 1 1 0 0.128 0.691 1.000 127 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(2) 2874070 2 2 2 1 1 1 0 0 0 0 0.778 0.692 1.000 128 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 GRB2(1), KLK2(1), PIK3CA(12), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1) 11712945 20 18 19 4 7 4 3 5 1 0 0.231 0.693 1.000 129 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 MAPK1(1), MYC(1), PLCB1(3), PRKCA(2), RAF1(1), RELA(2), TNF(1) 9524803 11 11 11 1 4 2 2 3 0 0 0.102 0.693 1.000 130 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE2(1), CDKN1B(5), CDKN2A(1) 5654499 8 8 8 2 0 1 0 1 6 0 0.793 0.694 1.000 131 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), PAPSS2(1), SEPHS1(1) 7793024 7 7 7 1 1 2 1 0 3 0 0.350 0.700 1.000 132 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(1), F2R(1), F2RL3(1), GNAI1(1), GNB1(1), GNGT1(1), ITGA1(1), MAPK1(1), PLA2G4A(3), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(2), RAF1(1), SYK(2), TBXAS1(1) 15097592 24 21 24 4 9 5 2 7 1 0 0.0771 0.701 1.000 133 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), UBQLN1(2) 7526117 7 7 7 0 2 1 0 3 1 0 0.115 0.712 1.000 134 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP3K1(1), MAPK1(1), PIK3CA(12), PIK3R1(1), RB1(2), RELA(2), SP1(2) 12241844 24 23 22 5 5 7 4 6 1 1 0.185 0.713 1.000 135 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(2), DHFR(1), SPR(1) 4110961 7 7 7 3 3 2 0 1 1 0 0.615 0.723 1.000 136 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), IL6(1), LDLR(1), LPL(1) 3363478 4 4 4 2 1 1 0 2 0 0 0.795 0.726 1.000 137 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), CTH(1), MUT(1) 3094776 3 3 3 2 1 0 0 0 2 0 0.981 0.735 1.000 138 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR171(1), GPR18(1), GPR68(1), GPR75(1) 6191204 6 6 6 1 2 1 0 3 0 0 0.350 0.737 1.000 139 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(1), EMR2(5), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GPR64(1), LPHN1(2), LPHN2(3), LPHN3(8), SCTR(1), VIPR1(1) 16744392 32 30 31 7 9 3 4 11 5 0 0.131 0.738 1.000 140 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY2(2), CSNK1E(1), PER1(2) 5342639 5 5 5 1 1 1 1 2 0 0 0.548 0.741 1.000 141 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), CES1(2) 3786245 3 3 3 1 0 0 0 3 0 0 0.845 0.752 1.000 142 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH5A1(1), EHHADH(5), GAD1(2), GAD2(6), HMGCL(1), PDHA2(3), SDHB(1) 16263884 31 31 29 8 12 5 3 6 5 0 0.176 0.757 1.000 143 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(5), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(1) 11669927 15 15 15 3 5 0 3 5 2 0 0.263 0.761 1.000 144 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), ACO2(1), FH(1), SDHB(1) 5083492 4 4 4 0 0 1 2 1 0 0 0.261 0.763 1.000 145 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 1988134 1 1 1 1 1 0 0 0 0 0 0.887 0.764 1.000 146 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(4), CREBBP(5), EP300(5), MAP3K7(2), TGFB1(1), TGFB2(2), TGFBR1(2) 16220024 30 27 30 5 7 1 5 6 11 0 0.154 0.768 1.000 147 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), IL4(1), IL6(1), IL7(1), IL9(1) 3830883 5 5 5 2 1 1 1 1 1 0 0.686 0.778 1.000 148 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(3), DPYS(2), ENPP1(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(2), PANK3(1) 10923140 16 16 15 4 2 3 3 3 5 0 0.513 0.781 1.000 149 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1) 8462385 8 8 8 1 4 0 1 3 0 0 0.331 0.787 1.000 150 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(2), FH(1), SDHA(1) 5931218 5 5 5 0 0 0 2 3 0 0 0.296 0.791 1.000 151 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA2(1), GLB1(1), HEXB(2), LCT(3), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1) 10424869 15 13 15 4 6 2 1 2 4 0 0.401 0.791 1.000 152 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), UGDH(2), UGP2(1) 3095343 4 4 4 2 1 0 1 2 0 0 0.817 0.794 1.000 153 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(1), CPOX(1), HMBS(1) 4698741 3 3 3 1 1 0 0 2 0 0 0.751 0.806 1.000 154 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(5), DFFA(1), GZMA(1), HMGB2(2), NME1(1), PRF1(1) 6688204 11 11 11 4 3 2 2 1 3 0 0.679 0.810 1.000 155 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1) 5028985 9 9 8 4 3 0 2 3 1 0 0.763 0.811 1.000 156 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1) 5028985 9 9 8 4 3 0 2 3 1 0 0.763 0.811 1.000 157 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(1), FSHR(1), GNAS(2) 6025226 7 6 7 2 2 0 2 3 0 0 0.699 0.813 1.000 158 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(1), MPO(1), TPO(3), TYR(2) 6070417 9 9 9 3 6 2 0 1 0 0 0.446 0.816 1.000 159 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1) 4982734 4 4 4 0 1 0 0 2 1 0 0.294 0.818 1.000 160 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(3), BCR(1), GRB2(1), MAP2K4(3), MAP3K1(1), MYC(1), PIK3CA(12), PIK3R1(1), RAF1(1), SOS1(1), STAT1(1), STAT5B(1) 17474555 27 25 25 5 6 7 4 10 0 0 0.110 0.821 1.000 161 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1), SHMT2(1) 2615075 2 2 2 0 1 1 0 0 0 0 0.393 0.829 1.000 162 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(9), DLL1(1), FZD1(2), GSK3B(1), NOTCH1(3) 12498712 16 15 16 4 3 2 2 0 9 0 0.319 0.830 1.000 163 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(3), AKT2(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(3), PITX2(1), PLD1(3), PLD2(1), VN1R1(2) 28255145 34 32 33 4 6 8 2 10 8 0 0.0196 0.830 1.000 164 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACADVL(1), ACSL1(2), EHHADH(5), SLC25A20(1) 10621723 11 11 10 2 5 1 0 2 3 0 0.384 0.841 1.000 165 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(4), MARS2(1), MAT1A(1) 10944985 13 13 13 3 4 2 2 0 5 0 0.276 0.842 1.000 166 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 CDC25A(1), CDC25B(2), MYT1(1), RB1(2), YWHAH(1) 6616952 7 7 7 2 3 1 1 1 0 1 0.522 0.844 1.000 167 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(4), JUND(1) 2360150 6 6 6 4 3 1 1 1 0 0 0.836 0.846 1.000 168 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), MAPK1(1), PIK3C2G(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(2), RAF1(1), RELA(2) 17042602 30 25 29 5 8 5 5 9 3 0 0.120 0.847 1.000 169 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3) 8000117 8 7 8 2 2 0 0 3 3 0 0.555 0.849 1.000 170 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(1), ALOX15(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2J2(1), CYP4F2(2), CYP4F3(1), DHRS4(1), GPX4(1), GPX6(1), LTC4S(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1) 24485619 37 36 37 6 11 6 2 12 6 0 0.0323 0.853 1.000 171 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCG2(2), BCHE(2), CES1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1) 14430185 11 11 11 0 2 1 1 4 3 0 0.0768 0.854 1.000 172 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(3), TYK2(1) 6628280 8 7 8 2 0 1 1 3 3 0 0.546 0.856 1.000 173 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(3), TYK2(1) 6628280 8 7 8 2 0 1 1 3 3 0 0.546 0.856 1.000 174 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), PDHA2(3), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(1), SDHB(1), SDHC(2) 17836648 21 20 21 3 2 5 2 7 5 0 0.0876 0.859 1.000 175 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), CS(2), ME1(2), PC(1) 5821959 6 6 6 2 0 1 1 2 2 0 0.607 0.860 1.000 176 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(3), MAP3K1(1), NCOR2(4), THRA(2) 10833818 12 12 12 2 5 0 0 5 2 0 0.280 0.860 1.000 177 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATR(2), YWHAH(1) 5640615 3 3 3 1 1 1 0 1 0 0 0.813 0.861 1.000 178 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(3), AGTR1(2), BDKRB2(1), NOS3(2) 6160421 8 7 8 2 3 2 0 2 1 0 0.431 0.862 1.000 179 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(1), GCNT2(2), ST8SIA1(1) 3864391 5 5 5 5 0 2 1 0 2 0 0.950 0.870 1.000 180 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(2), GOT1(1), GOT2(1), PAH(1), YARS2(2) 5481400 7 6 7 2 4 1 0 1 1 0 0.434 0.874 1.000 181 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 RELA(2), TNFRSF13B(2), TRAF2(4), TRAF5(1) 9133933 9 8 9 2 3 2 1 2 1 0 0.327 0.874 1.000 182 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 1946930 1 1 1 1 0 1 0 0 0 0 0.891 0.875 1.000 183 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(2), GLB1(1), HEXB(2), LCT(3) 8995979 10 9 10 2 4 2 0 3 1 0 0.288 0.876 1.000 184 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(2), DBH(5), GAD1(2), GAD2(6), HDC(1), MAOA(2), PAH(1), PNMT(1), TPH1(1) 9046733 22 22 22 7 9 3 2 4 4 0 0.366 0.876 1.000 185 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(2), ANXA4(1), ANXA6(2), EDNRA(1), HPGD(1), HSD11B1(1), PLA2G4A(3), PTGIR(2), PTGIS(1), PTGS1(2), PTGS2(3), SCGB1A1(1), TBXAS1(1) 13059878 21 21 21 5 4 4 2 6 5 0 0.261 0.880 1.000 186 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(1), MMP9(2) 4447141 3 3 3 0 0 0 1 2 0 0 0.527 0.880 1.000 187 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), GOT1(1), GOT2(1), ME1(2), ME3(1), PGK2(2), TKT(1), TKTL2(2) 12697918 12 12 12 2 1 3 2 4 2 0 0.156 0.882 1.000 188 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 DCXR(1), UGDH(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2) 11106869 10 10 10 2 3 0 1 4 2 0 0.453 0.885 1.000 189 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(2), GAD2(6) 3622723 8 8 8 5 3 1 1 1 2 0 0.857 0.887 1.000 190 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), GNGT1(1), HTR2C(2), PLCB1(3), TUB(1) 4523066 8 7 8 3 3 1 1 3 0 0 0.667 0.890 1.000 191 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB7(1), NDUFS2(1), NDUFV1(1) 4379385 5 5 5 2 1 0 3 1 0 0 0.736 0.891 1.000 192 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(3), AKT2(1), ANKRD6(1), APC(9), AXIN2(2), DACT1(3), DKK1(2), DKK2(2), GSK3A(2), GSK3B(1), LRP1(5), NKD2(1), PTPRA(3), WIF1(2) 24336774 37 32 36 7 8 9 3 7 10 0 0.0537 0.894 1.000 193 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(2), EPOR(1), GRIN1(2), RELA(2), SOD2(1) 7981174 10 8 10 2 5 1 1 1 2 0 0.416 0.898 1.000 194 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(4) 5319687 4 3 4 1 0 1 0 0 3 0 0.906 0.899 1.000 195 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), UGDH(2) 2429614 3 3 3 2 1 0 1 1 0 0 0.869 0.903 1.000 196 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(1), RELA(2), RIPK1(1), TANK(1), TNFAIP3(1), TRAF1(1), TRAF2(4) 14118187 14 13 14 2 6 2 3 2 1 0 0.0940 0.904 1.000 197 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(3), GNAS(2), GNB1(1), GNGT1(1), NOS3(2), NPPA(1), NR3C1(1), PIK3CA(12), PIK3R1(1), RELA(2), SYT1(1) 11235519 27 25 25 7 4 8 3 10 2 0 0.431 0.905 1.000 198 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATR(2), BRCA1(1), CDC25A(1), CDC25B(2), CDKN1A(2), EP300(5), MDM2(1), MYT1(1), PRKDC(7), RPS6KA1(1), YWHAH(1), YWHAQ(1) 21864155 25 21 25 3 12 4 1 6 2 0 0.0599 0.908 1.000 199 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(2), PPAP2B(1) 14607935 22 19 22 4 7 1 1 7 6 0 0.202 0.908 1.000 200 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 3066735 2 2 2 2 0 0 0 1 1 0 0.963 0.908 1.000 201 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL2L11(1), CES1(2) 6754969 4 4 4 0 0 1 0 3 0 0 0.400 0.910 1.000 202 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(1), SHMT2(1) 3443301 2 2 2 0 1 1 0 0 0 0 0.409 0.915 1.000 203 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNB1(1), RELA(2), TNFSF11(1) 6974547 4 4 4 0 0 1 1 1 1 0 0.370 0.915 1.000 204 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(1), CRK(1), DOCK1(2), GRB2(1), HGF(3), ITGA1(1), MAP4K1(1), MAPK1(1), MET(2), PAK1(1), PIK3CA(12), PIK3R1(1), PTK2(2), PXN(2), RAF1(1), RAP1A(1), SOS1(1), STAT3(6) 26956553 40 36 39 7 8 7 8 13 4 0 0.0573 0.916 1.000 205 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(1), F2R(1), F3(1), F5(4), F7(2), FGA(5), FGB(2), PROC(2), PROS1(2) 10350837 22 22 22 7 9 2 2 8 1 0 0.467 0.917 1.000 206 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(2), PDHA2(3) 4373588 6 6 6 3 2 1 0 1 2 0 0.639 0.919 1.000 207 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(1), HMBS(1) 4805719 2 2 2 1 1 0 0 1 0 0 0.842 0.920 1.000 208 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(2), ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(3) 10018265 13 12 13 4 5 1 4 3 0 0 0.413 0.920 1.000 209 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(4), HEXB(2), HK2(1), HK3(2), PGM3(2) 10663435 11 11 11 3 5 2 0 2 2 0 0.443 0.922 1.000 210 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADSB(2), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(2), EHHADH(5), GAD1(2), GAD2(6) 18328048 32 30 31 9 10 4 6 6 6 0 0.300 0.926 1.000 211 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(3), APAF1(1), PRKCA(2), PTK2(2), PXN(2), STAT1(1), TLN1(2) 12826965 13 11 12 1 3 4 0 4 2 0 0.0727 0.928 1.000 212 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(3), CCR4(1), CCR7(2), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3), TGFB1(1), TGFB2(2) 12532081 17 16 17 4 2 0 2 10 3 0 0.422 0.929 1.000 213 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(3), EDNRA(1), EGF(2), EGFR(3), MYC(1), PLCG1(1), PRKCA(2), RELA(2) 12677183 15 15 15 4 3 1 2 8 1 0 0.466 0.931 1.000 214 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), HMGB2(2), TOP2A(2), TOP2B(2) 5618063 7 7 7 3 1 1 1 1 3 0 0.920 0.932 1.000 215 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1) 2676285 2 2 2 4 0 0 0 1 1 0 0.992 0.933 1.000 216 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(2), EGF(2), EGFR(3), GRB2(1), MET(2), PDGFRA(2), PRKCA(2), SH3GLB2(1) 12251351 16 15 16 4 5 0 3 8 0 0 0.351 0.936 1.000 217 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR1(2), CMA1(2), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1) 15719706 17 16 17 4 4 3 1 4 5 0 0.366 0.938 1.000 218 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(4), GNA13(1), GNB1(1), GNGT1(1), MYLK(4), PLCB1(3), PRKCA(2), ROCK1(5) 13036661 23 21 22 6 4 4 4 9 2 0 0.406 0.938 1.000 219 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP2K4(3), MAP3K3(1), MAP3K7(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(4) 17126105 19 18 19 4 5 2 1 7 4 0 0.288 0.939 1.000 220 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CITED2(1), CPT1B(1), CREBBP(5), DUSP1(1), EHHADH(5), EP300(5), HSD17B4(3), LPL(1), MAPK1(1), ME1(2), MYC(1), NCOA1(2), NCOR1(8), NCOR2(4), NR2F1(1), NRIP1(2), PDGFA(1), PIK3CA(12), PIK3R1(1), PPARA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PTGS2(3), RB1(2), RELA(2), SP1(2), STAT5B(1), TNF(1) 39850152 75 61 74 13 22 13 9 17 13 1 0.00631 0.941 1.000 221 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1) 3488141 1 1 1 0 0 0 0 0 1 0 1.000 0.941 1.000 222 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(3), ITGAM(2), ITGB2(2), SELE(1) 6507440 8 7 8 3 4 1 1 2 0 0 0.560 0.942 1.000 223 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1) 6045527 7 7 7 3 1 1 1 1 3 0 0.903 0.942 1.000 224 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(2) 4672027 2 2 2 0 1 0 1 0 0 0 0.467 0.944 1.000 225 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 BCAR1(1), CTNNA1(1), CTNNA2(4), PTK2(2), PXN(2) 11021619 10 9 10 1 4 1 1 2 2 0 0.214 0.945 1.000 226 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), PFKL(2) 5829043 4 4 4 3 1 0 0 0 3 0 0.873 0.946 1.000 227 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(1), RELA(2), TNFAIP3(1) 11398434 7 7 7 1 3 2 1 0 1 0 0.224 0.946 1.000 228 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA2(1), PSMA6(1), PSMB6(1) 5523028 3 3 3 0 0 0 0 2 1 0 0.681 0.947 1.000 229 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1), NAT6(1) 16387724 15 15 15 2 4 1 0 5 5 0 0.237 0.948 1.000 230 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD8A(1), IL6(1) 3904311 3 3 3 3 1 1 0 0 1 0 0.876 0.948 1.000 231 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1(2), MST1R(3), TNF(1) 4130517 6 5 6 3 4 1 0 0 1 0 0.789 0.948 1.000 232 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), IKBKB(1), IL4(1), MAP3K1(1), MAP3K5(1), RELA(2), TRAF2(4) 12189465 12 11 12 3 6 1 1 4 0 0 0.439 0.949 1.000 233 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 RELA(2) 5611782 2 2 2 1 0 1 1 0 0 0 0.742 0.950 1.000 234 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP5(1), ACPT(3), ENPP1(2), ENPP3(1), MTMR2(2), MTMR6(1), RFK(1), TYR(2) 9495845 14 14 13 5 3 1 2 3 5 0 0.647 0.951 1.000 235 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 GRB2(1), SHC1(2), SOS1(1) 5261982 4 4 4 2 3 1 0 0 0 0 0.733 0.951 1.000 236 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 GRB2(1), IGF1R(2), IRS1(2), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1) 15309242 22 19 21 5 6 4 4 7 1 0 0.308 0.951 1.000 237 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGTR1(2), ATF2(2), EGFR(3), GRB2(1), MAP2K4(3), MAP3K1(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), PAK1(1), PRKCA(2), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 20728836 28 26 28 5 13 2 3 9 1 0 0.0958 0.951 1.000 238 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(2), EGFR(3), TF(1) 8116688 8 8 8 3 1 1 0 6 0 0 0.793 0.952 1.000 239 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), RAC1(1), WASF1(1) 5126289 4 4 4 2 0 1 1 2 0 0 0.837 0.952 1.000 240 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 DNM1(1), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(3), SYNJ2(2), SYT1(1) 13693947 15 15 15 4 3 1 2 7 2 0 0.499 0.954 1.000 241 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1) 3549467 7 7 7 4 3 2 0 1 1 0 0.770 0.955 1.000 242 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA2(1), PSMA6(1), PSMB6(1), PSMC2(1), PSMD1(1), PSMD2(1), PSMD6(1) 10120211 7 7 7 0 2 0 0 4 1 0 0.254 0.956 1.000 243 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1), NAT6(1) 10461086 9 9 9 2 2 0 0 3 4 0 0.570 0.957 1.000 244 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(2), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT2(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 6757191 13 13 13 5 6 4 0 1 2 0 0.540 0.958 1.000 245 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(1), FUT3(1) 3209586 3 3 3 2 0 2 0 1 0 0 0.818 0.959 1.000 246 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 EGF(2), EGFR(3), GRB2(1), JAK1(3), MAP2K4(3), MAP3K1(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6) 23307535 40 34 39 9 10 6 4 18 2 0 0.196 0.959 1.000 247 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), CDKN1A(2), MDM2(1), PCNA(1), RB1(2) 6962457 7 5 7 2 2 1 1 0 2 1 0.499 0.961 1.000 248 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), AKT1(3), IGF1R(2), IL3RA(2), PIK3CA(12), PIK3R1(1), PRKAR1A(1), PRKAR1B(2), YWHAH(1) 13851802 26 23 24 7 6 6 4 10 0 0 0.294 0.962 1.000 249 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(1), BMPR2(1) 3943685 3 3 3 2 0 0 0 2 1 0 0.978 0.962 1.000 250 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(3), STAT1(1), STAT2(1), TYK2(1) 6842380 7 6 7 3 0 1 0 3 3 0 0.844 0.963 1.000 251 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(3), STAT1(1) 5198245 4 3 4 2 0 1 0 2 1 0 0.852 0.964 1.000 252 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), SDHA(1), SDHB(1) 12426498 10 10 10 2 1 1 3 4 1 0 0.397 0.965 1.000 253 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PLCG1(1), PRKCA(2) 4213350 3 3 3 1 2 0 0 1 0 0 0.710 0.966 1.000 254 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND3(1), CCNH(1), CDC25A(1), CDK7(1), CDKN1A(2), CDKN1B(5), CDKN2A(1), RB1(2), TFDP1(1) 10159277 16 13 16 6 3 1 3 2 6 1 0.750 0.968 1.000 255 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(4), MARS2(1), MAT1A(1) 13034318 14 14 14 4 4 2 2 1 5 0 0.379 0.969 1.000 256 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNF(1), TRAF2(4) 5242010 6 5 6 3 3 0 1 2 0 0 0.710 0.970 1.000 257 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BIK(1), BIRC2(1), DFFA(1) 8496863 4 4 4 0 0 2 0 1 1 0 0.354 0.971 1.000 258 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), CD38(1), ENPP1(2), ENPP3(1), NADK(2), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), NUDT12(2) 13584014 20 18 20 6 6 3 1 5 5 0 0.441 0.972 1.000 259 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(2), GLB1(1), HEXB(2), LCT(3), SPAM1(3) 12832398 13 12 13 3 6 2 0 4 1 0 0.348 0.974 1.000 260 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(1), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(2), MEF2A(1), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(2), PIK3CA(12), PIK3R1(1), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1) 21877281 35 28 33 6 11 6 5 12 1 0 0.0487 0.975 1.000 261 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(2), B4GALT2(2), B4GALT5(1), ST3GAL1(2) 4953558 7 6 7 3 5 0 0 2 0 0 0.803 0.975 1.000 262 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH12(1) 3008732 1 1 1 1 1 0 0 0 0 0 0.894 0.976 1.000 263 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK3(1), MAPK1(1), STAT3(6), TYK2(1) 7384234 12 11 12 6 1 2 1 5 3 0 0.887 0.976 1.000 264 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1) 8353949 9 9 9 4 3 0 3 2 1 0 0.730 0.976 1.000 265 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(9), CREBBP(5), FZD1(2), GSK3B(1), MAP3K7(2), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(3), WIF1(2) 17508512 28 26 28 7 7 2 4 3 12 0 0.361 0.977 1.000 266 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), ASAH1(1), CERK(1), CREB3(1), DAG1(1), EPHB2(3), ITPKB(2), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK8IP3(3) 18008709 28 26 28 7 8 4 0 4 12 0 0.319 0.977 1.000 267 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRA(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL1A(1), IL4(1), IL6(1), IL7(1), PDGFA(1), TGFB1(1), TGFB2(2), TNF(1) 8374689 14 13 14 5 5 2 2 3 2 0 0.529 0.977 1.000 268 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(4), ATR(2), CCNA1(1), CDC25A(1), CDKN1A(2), CDKN1B(5), CDKN2A(1), DHFR(1), GSK3B(1), RB1(2), TFDP1(1), TGFB1(1), TGFB2(2) 14628154 24 19 24 8 5 1 5 2 10 1 0.735 0.977 1.000 269 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), BTK(1), EEA1(2), GSK3A(2), GSK3B(1), PDPK1(1), PFKL(2), PFKM(2), PFKP(2), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(2) 15772748 22 22 21 5 3 5 2 8 4 0 0.174 0.978 1.000 270 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(1), EP300(5), NOS3(2), VHL(2) 10686093 12 10 12 3 6 1 1 3 1 0 0.435 0.978 1.000 271 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(12), PIK3R1(1) 8098614 16 14 15 5 6 3 2 5 0 0 0.559 0.979 1.000 272 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY2(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(2), PER2(2), PER3(2) 10752630 11 10 11 3 2 2 1 4 2 0 0.559 0.980 1.000 273 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP3(1), ARFGEF2(1), COPA(1), GBF1(4), GPLD1(1), KDELR3(1) 10248926 9 9 9 3 4 2 1 1 1 0 0.466 0.980 1.000 274 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(3), GOT1(1) 4918779 4 4 4 4 1 0 0 2 1 0 0.971 0.982 1.000 275 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1) 12695233 19 16 19 5 9 1 1 6 2 0 0.388 0.982 1.000 276 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(2), FUT1(1), FUT2(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 6364479 10 10 10 5 4 4 0 0 2 0 0.721 0.983 1.000 277 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), FDXR(1), SHMT1(1) 10074986 13 13 13 4 3 2 0 5 3 0 0.694 0.983 1.000 278 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(2), ENPP3(1), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5E(1), NT5M(1) 9176221 13 13 13 5 3 2 1 4 3 0 0.600 0.984 1.000 279 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 GRB2(1), JAK1(3), MAP2K4(3), MAP3K1(1), PDGFA(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6) 21688869 38 31 37 9 12 7 4 13 2 0 0.172 0.984 1.000 280 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1), NAT6(1) 15754167 13 11 13 2 4 0 1 4 4 0 0.269 0.984 1.000 281 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(5), FAH(1), GOT1(1), GOT2(1), HGD(1), HPD(1), MAOA(2), PNMT(1), TPO(3), TYR(2) 19902512 29 29 29 8 11 4 3 5 6 0 0.294 0.984 1.000 282 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1), GSK3B(1), PPP2CA(1) 5810178 3 3 3 4 0 0 0 1 2 0 0.997 0.985 1.000 283 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), ARHGDIB(1), CASP1(2), PRF1(1) 8154739 7 7 7 3 2 2 0 2 1 0 0.755 0.985 1.000 284 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 RB1(2), TFDP1(1) 5211707 3 3 3 2 0 0 2 0 0 1 0.811 0.985 1.000 285 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATR(2), BRCA1(1), BRCA2(7), FANCA(2), FANCD2(2), FANCF(1), FANCG(1), HUS1(1), RAD17(1), RAD51(1) 23395675 19 19 19 3 2 1 1 8 7 0 0.511 0.986 1.000 286 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C3(1), AKR1C4(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2S1(2), CYP3A43(1), CYP3A7(1), EPHX1(2), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2) 36238305 60 51 60 10 15 5 10 22 8 0 0.0295 0.986 1.000 287 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(5), DAXX(1), PAX3(3), PML(3), RB1(2), SIRT1(2), SP100(2), TNF(1) 11190621 19 17 19 6 7 2 5 3 1 1 0.392 0.987 1.000 288 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), GOT1(1), GOT2(1), ME1(2), ME3(1), TKT(1) 11350016 8 8 8 2 0 2 1 4 1 0 0.414 0.987 1.000 289 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA2(1), PSMA6(1), PSMB6(1), RPN1(1) 8138177 4 4 4 1 1 0 0 2 1 0 0.752 0.987 1.000 290 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSD(1), ARSE(2), ASAH1(1), GAL3ST1(2), GLB1(1), LCT(3), NEU1(1), NEU2(1), NEU4(1), PPAP2A(2), PPAP2B(1), SMPD2(2), SPTLC1(1) 15185762 21 19 21 6 7 3 3 6 2 0 0.321 0.987 1.000 291 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL1A(1), IL6(1), IL9(1), TGFB1(1), TGFB2(2) 5207087 7 7 7 6 1 1 3 1 1 0 0.953 0.987 1.000 292 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(2), AKT1(3), CAMK2A(1), CAMK2D(1), GNAS(2), GRB2(1), MAPK1(1), PIK3CA(12), PIK3R1(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1) 18092276 35 31 33 9 10 7 3 15 0 0 0.309 0.987 1.000 293 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(2), GHR(1), GRB2(1), IRS1(2), MAPK1(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5B(1) 20601029 29 26 28 6 10 6 3 9 1 0 0.172 0.988 1.000 294 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), RB1(2), TFDP1(1) 5381609 4 4 4 3 0 1 2 0 0 1 0.844 0.988 1.000 295 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12B(1), IL12RB2(1), STAT4(4), TYK2(1) 9194009 8 8 8 3 0 0 1 3 4 0 0.738 0.988 1.000 296 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(2), DFFA(1), LMNA(2), PRF1(1) 12197547 9 9 9 2 3 2 0 2 2 0 0.492 0.988 1.000 297 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC1(1), APOBEC3B(2), APOBEC3G(1) 4637147 6 6 6 4 3 1 0 1 1 0 0.911 0.989 1.000 298 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(1), TYK2(1) 7890248 10 9 10 5 2 1 0 4 3 0 0.868 0.989 1.000 299 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 GRB2(1), IRS1(2), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1) 15729505 20 18 19 5 6 4 3 6 1 0 0.380 0.989 1.000 300 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), HLA-A(1), PAK1(1), PIK3CA(12), PIK3R1(1), RAC1(1), SYK(2), VAV1(3) 11733265 22 21 21 7 7 3 3 8 1 0 0.647 0.989 1.000 301 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), UGDH(2) 5363995 7 7 7 5 1 0 3 2 1 0 0.945 0.990 1.000 302 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 GRB2(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5B(1) 18654548 29 24 28 6 8 6 4 10 1 0 0.167 0.990 1.000 303 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(2), CYP2A6(2) 5043725 5 5 5 3 3 0 1 0 1 0 0.857 0.990 1.000 304 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(2), GCK(4), GMDS(1), GMPPB(1), HK2(1), HK3(2), MPI(1), PFKFB1(2), PFKFB4(1), PFKM(2), PFKP(2), PMM1(1) 14990664 20 20 20 6 6 1 3 6 4 0 0.313 0.991 1.000 305 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), ITPKB(2), OCRL(3), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CG(4), PLCB1(3), PLCB4(8), PLCG1(1), PLCG2(2) 28148077 43 36 42 8 11 11 5 12 4 0 0.0489 0.992 1.000 306 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(1), AKT1(3), AKT2(1), BTK(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PIK3CA(12), PPP1R13B(1), RPS6KA1(1), SHC1(2), SOS1(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 22251869 35 32 33 9 9 8 3 10 5 0 0.222 0.992 1.000 307 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), NFATC1(1), NFATC2(2), PRKAR1A(1), PRKAR1B(2) 7641119 7 7 7 3 3 0 1 3 0 0 0.674 0.992 1.000 308 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(2), ITGAL(3), ITGB2(2), SELE(1) 7614889 8 7 8 4 3 0 2 3 0 0 0.787 0.992 1.000 309 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CFLAR(1), DAXX(1), DFFA(1), FAF1(4), LMNA(2), MAP2K4(3), MAP3K1(1), MAP3K7(2), PAK1(1), PAK2(1), PRKDC(7), PTPN13(1), RB1(2), RIPK2(2), SPTAN1(1) 25584967 31 27 31 5 12 4 4 5 5 1 0.0725 0.992 1.000 310 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), GSK3B(1), PPP1CA(1) 7291496 7 7 7 3 1 0 2 2 2 0 0.687 0.992 1.000 311 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 EGR1(2), KLK2(1), MAPK1(1), RAF1(1) 4899157 5 5 5 5 2 0 1 1 1 0 0.989 0.992 1.000 312 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(4), BRCA1(1), CDKN1A(2), MDM2(1), RAD51(1), RELA(2) 14370346 11 7 11 0 3 1 2 2 3 0 0.0765 0.992 1.000 313 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(2), DIAPH1(1), GSN(1), ITGA1(1), MAPK1(1), MYLK(4), PFN1(1), PIK3CA(12), PIK3R1(1), PTK2(2), PXN(2), RAF1(1), ROCK1(5), SHC1(2), TLN1(2) 23318008 38 33 36 9 10 6 6 11 5 0 0.263 0.993 1.000 314 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(1), GRB2(1), IL6(1), IL6ST(6), JAK1(3), JAK3(1), RAF1(1), SHC1(2), SOS1(1), STAT3(6) 14687574 23 21 23 7 4 6 2 5 6 0 0.564 0.993 1.000 315 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA2(1), GLB1(1), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1) 12850470 18 14 18 5 8 2 1 3 4 0 0.367 0.993 1.000 316 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(2), C6(4), C9(2) 7932261 8 8 8 4 2 1 0 3 2 0 0.827 0.993 1.000 317 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCL11(1), CFL1(1), GNAS(2), GNB1(1), GNGT1(1), LIMK1(2), MAPK1(1), PIK3C2G(1), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1) 15477768 18 14 18 3 5 2 1 8 2 0 0.337 0.993 1.000 318 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(5), HADHB(1), HMGCL(1), IVD(2), MCCC1(1), MUT(1) 22713993 32 30 30 9 10 3 4 8 7 0 0.353 0.993 1.000 319 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(1), GRB2(1), MAP2K4(3), MAP3K1(1), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1) 17631124 17 16 17 4 9 1 2 3 2 0 0.352 0.993 1.000 320 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP2C19(3), CYP2C9(2), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1), NAT6(1) 19489756 24 24 24 6 8 2 2 6 6 0 0.362 0.994 1.000 321 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(3), GLI2(3), GLI3(2), GSK3B(1), PRKAR1A(1), PRKAR1B(2), SHH(2), SUFU(1) 10491516 17 15 17 6 4 1 2 7 3 0 0.610 0.994 1.000 322 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1), SLC23A2(1), SLC2A1(1) 15604099 14 12 14 4 5 3 0 1 5 0 0.509 0.994 1.000 323 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), DAXX(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1), TNF(1) 7147926 8 8 8 6 2 1 1 2 2 0 0.969 0.994 1.000 324 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(2), MTA1(2) 6807655 5 5 5 6 2 1 0 0 2 0 0.968 0.994 1.000 325 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(2), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(5), EHMT2(1), PLOD1(1), PLOD3(2), SHMT1(1), SHMT2(1) 23306071 31 29 30 7 8 3 6 9 5 0 0.202 0.994 1.000 326 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), POLR2A(3), PRKAR1A(1), PRKAR1B(2) 8104129 7 6 7 3 5 0 0 2 0 0 0.663 0.995 1.000 327 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(4), PPP1CA(1), PPP2CA(1), PRKAG1(2) 11480864 13 13 13 6 0 0 3 6 4 0 0.875 0.995 1.000 328 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 RELA(2), TNF(1) 6207357 3 3 3 2 1 1 1 0 0 0 0.792 0.995 1.000 329 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX7A1(1), COX7C(1), NDUFA10(2), NDUFB7(1), NDUFS2(1), NDUFV1(1), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(1) 24066812 27 26 27 5 5 6 3 10 3 0 0.152 0.995 1.000 330 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(2), GOT1(1), GOT2(1), HPD(1), LPO(1), MAOA(2), MPO(1), TPO(3) 13746373 17 17 17 5 5 4 1 4 3 0 0.529 0.995 1.000 331 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1) 8817902 8 8 8 5 0 0 1 4 3 0 0.948 0.995 1.000 332 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKAG1(2) 6365045 3 3 3 2 0 0 2 1 0 0 0.861 0.996 1.000 333 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1) 7272061 8 8 8 4 4 0 0 3 1 0 0.851 0.996 1.000 334 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), RPL10A(3), RPL12(1), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(1), RPS11(2), RPS9(2) 14179867 17 17 17 4 4 2 0 8 3 0 0.480 0.996 1.000 335 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(1), CYP4F2(2), CYP4F3(1), EPX(2), LPO(1), MPO(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1), TPO(3) 17536159 24 24 24 6 8 6 0 8 2 0 0.181 0.996 1.000 336 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(2), B4GALT2(2), GAA(1), GALK1(1), GALK2(1), GALT(1), GANAB(1), GCK(4), GLB1(1), HK2(1), HK3(2), LCT(3), MGAM(6), PFKM(2), PFKP(2), PGM1(1), PGM3(2) 20440216 33 29 32 8 15 3 3 7 5 0 0.108 0.996 1.000 337 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(9), AR(2), ASAH1(1), DAG1(1), EGFR(3), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PHKA2(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PITX2(1), RAF1(1) 32594607 56 53 54 13 13 9 4 16 14 0 0.166 0.996 1.000 338 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CAPNS1(1), EP300(5), MEF2D(1), NFATC1(1), NFATC2(2), PPP3CA(1), PPP3CC(1), PRKCA(2), SYT1(1) 15370361 16 13 16 3 8 0 2 6 0 0 0.195 0.996 1.000 339 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), DPM1(1), MAN1A1(2), MGAT5(1), RPN1(1), ST6GAL1(1) 12527646 12 11 12 3 5 2 0 5 0 0 0.439 0.996 1.000 340 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(1), DHRS7(1), DHRSX(1), HEMK1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1) 9466136 11 11 11 5 1 0 1 5 4 0 0.834 0.996 1.000 341 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(2), CAMK1G(1), FPR1(2), GNB1(1), GNGT1(1), MAP3K1(1), MAPK1(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(2), PAK1(1), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(2), SYT1(1) 23719895 28 23 28 5 10 2 4 9 3 0 0.141 0.996 1.000 342 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), IKBKB(1), IRAK1(1), LY96(1), MAP2K4(3), MAP3K1(1), MAP3K7(2), PPARA(2), RELA(2), TLR10(1), TLR4(1), TLR7(1), TLR9(1) 22850683 18 15 18 3 11 1 1 4 1 0 0.124 0.996 1.000 343 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA1(1), CA12(1), CA14(2), CA2(2), CA3(1), CA4(1), CA5A(1), CA6(1), CA8(3), CA9(2), CPS1(3), CTH(1), GLUL(1), HAL(1) 11986150 22 21 22 9 6 4 1 7 4 0 0.701 0.996 1.000 344 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(2), GOSR1(1), SNAP25(2), STX16(1), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1) 10501297 11 10 11 3 4 0 1 3 3 0 0.582 0.997 1.000 345 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), HLA-A(1), ITGAL(3), ITGB2(2), PRF1(1) 5503190 8 7 8 6 4 0 0 3 1 0 0.925 0.997 1.000 346 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACADVL(1), ACAT1(1), ACOX3(1), ACSL1(2), ACSL6(2), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CPT1B(1), CPT1C(4), EHHADH(5), HADH(1), HADHB(1), HSD17B4(3) 30890285 38 31 37 7 13 4 7 6 8 0 0.0484 0.997 1.000 347 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(1), JAK1(3), JAK3(1), STAT1(1), STAT3(6), STAT5B(1), TYK2(1) 11567240 16 14 16 7 0 3 2 7 4 0 0.806 0.997 1.000 348 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(1), GPX4(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1) 10842023 10 10 10 4 2 1 2 5 0 0 0.734 0.997 1.000 349 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(2), MBTPS2(1), SCAP(1), SREBF2(1) 7503922 7 7 7 6 1 0 0 4 2 0 0.992 0.997 1.000 350 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(9), CREBBP(5), EP300(5), FZD1(2), GSK3B(1), LEF1(2), PITX2(1), TRRAP(2) 19933118 27 26 27 8 9 2 4 3 9 0 0.363 0.997 1.000 351 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX3(1), ELOVL6(1), FASN(2), SCD(1) 8950370 7 7 7 4 0 0 2 2 3 0 0.939 0.997 1.000 352 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(2), EHHADH(5), GAD1(2), GAD2(6) 17020004 26 26 26 9 8 4 5 4 5 0 0.538 0.998 1.000 353 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(1), ABCB4(1), ABCC3(2) 9031807 8 8 8 5 2 1 1 2 2 0 0.917 0.998 1.000 354 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD8A(1), ITGAL(3), ITGB2(2), PTPRC(7) 6781513 13 12 13 7 5 1 2 4 1 0 0.764 0.998 1.000 355 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(1), ACO1(1), ACO2(1), ACSS1(1), ACSS2(1), FH(1) 7837950 6 6 6 3 0 1 2 2 1 0 0.783 0.998 1.000 356 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT4(2), B4GALT1(2), B4GALT2(2), FUT1(1), FUT2(1), FUT3(1), GCNT2(2), ST3GAL6(1), ST8SIA1(1) 10194983 14 12 14 6 3 3 1 4 2 1 0.735 0.998 1.000 357 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(1), EPRS(3), GARS(1), IARS(1), KARS(1), LARS(2), LARS2(2), MARS2(1), QARS(1), SARS(1), TARS(1), WARS(1) 20236338 18 16 18 4 5 3 2 5 3 0 0.378 0.998 1.000 358 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(3) 5837300 4 4 4 3 1 1 1 0 1 0 0.866 0.998 1.000 359 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(7), PLCB1(3), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(2) 10117049 17 16 16 7 6 2 0 6 3 0 0.693 0.998 1.000 360 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), GCK(4), HK2(1), HK3(2), LDHC(1), PDHA2(3), PFKM(2), PFKP(2), PGM1(1), PGM3(2) 30787491 37 35 36 8 13 3 6 9 6 0 0.0803 0.998 1.000 361 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), GCK(4), HK2(1), HK3(2), LDHC(1), PDHA2(3), PFKM(2), PFKP(2), PGM1(1), PGM3(2) 30787491 37 35 36 8 13 3 6 9 6 0 0.0803 0.998 1.000 362 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(2), IL12A(1), IL12B(1), IL12RB2(1), STAT4(4), TYK2(1) 11696510 10 10 10 4 1 1 1 3 4 0 0.705 0.999 1.000 363 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2I(1), UBE2L3(1), UBE2N(1) 6638844 4 4 4 3 1 1 0 1 1 0 0.945 0.999 1.000 364 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(1), IL4(1), IL4R(3), IRS1(2), JAK1(3), JAK3(1), SHC1(2), STAT6(2) 9269593 18 16 17 7 5 3 0 7 3 0 0.745 0.999 1.000 365 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 LSS(1), NQO1(1), SQLE(1) 6910272 3 3 3 4 2 0 0 0 1 0 0.967 0.999 1.000 366 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), PDE1B(1), PLCB1(3) 7013960 6 6 6 4 2 1 1 1 1 0 0.822 0.999 1.000 367 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(3), GALNT3(2), GALNT4(2), GALNT8(2), GCNT1(1), ST3GAL1(2), WBSCR17(1) 9090780 13 12 13 7 6 1 0 4 2 0 0.915 0.999 1.000 368 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(1), L1CAM(6), SELP(3) 9933649 16 15 16 7 5 0 3 5 3 0 0.750 0.999 1.000 369 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(3), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), IGF1R(2), KLK2(1), MAPK1(1), MYC(1), PDGFRA(2), PPP2CA(1), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1), STAT3(6) 20502397 30 28 30 8 7 3 3 14 3 0 0.426 0.999 1.000 370 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(7) 9552824 14 13 14 6 6 1 2 5 0 0 0.705 0.999 1.000 371 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(3), ACE2(1), AGTR1(2), ANPEP(1), CMA1(2), CTSG(1), ENPEP(1), LNPEP(1), MAS1(1), MME(2), THOP1(1) 13324683 16 14 16 5 5 3 1 6 1 0 0.480 0.999 1.000 372 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(3), PLA2G2A(1), PTPRU(3), STAT1(1) 7254010 8 7 8 4 2 1 0 4 1 0 0.839 0.999 1.000 373 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CBS(1), CTH(1), HEMK1(1), LCMT2(1), MARS2(1), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), PRMT8(1), SEPHS1(1), SEPHS2(3) 15706354 18 18 18 6 2 2 3 5 6 0 0.638 0.999 1.000 374 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS2(3), ENPP7(1), GAL3ST1(2), GLB1(1), LCT(3), NEU1(1), NEU2(1), NEU4(1), PPAP2A(2), PPAP2B(1), SGMS1(1), SMPD2(2), SMPD3(1), SMPD4(1), SPHK2(1), SPTLC1(1) 22389729 29 22 29 8 12 4 5 5 3 0 0.192 0.999 1.000 375 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA2(1), GALNS(2), GLB1(1), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1), SPAM1(3) 21625146 25 20 25 6 12 2 1 6 4 0 0.249 0.999 1.000 376 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(3), JAK3(1), PIAS3(1), PTPRU(3), STAT3(6) 9596020 15 13 15 7 2 3 2 6 2 0 0.836 0.999 1.000 377 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(1), PGAP1(1), PIGA(1), PIGB(2), PIGH(1), PIGO(2), PIGQ(3) 14985492 11 10 11 3 2 1 2 4 2 0 0.569 0.999 1.000 378 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(1), ACTG1(2), ARHGEF2(3), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTTN(1), KRT18(1), LY96(1), PRKCA(2), ROCK1(5), TLR4(1), TLR5(2), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(1), YWHAQ(1), YWHAZ(1) 32050447 45 36 44 8 12 3 3 17 10 0 0.111 0.999 1.000 379 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ACTB(1), ACTG1(2), ARHGEF2(3), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTTN(1), KRT18(1), LY96(1), PRKCA(2), ROCK1(5), TLR4(1), TLR5(2), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(1), YWHAQ(1), YWHAZ(1) 32050447 45 36 44 8 12 3 3 17 10 0 0.111 0.999 1.000 380 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K4(3), MAP3K1(1), MAPK1(1), NSMAF(2), RAF1(1), RELA(2), RIPK1(1), TRAF2(4) 12895336 15 14 15 5 5 2 3 5 0 0 0.505 0.999 1.000 381 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), ENO1(2), GCK(4), GOT1(1), GOT2(1), HK2(1), HK3(2), LDHC(1), PC(1), PDHA2(3), PDHX(1), PFKL(2), PFKM(2), PFKP(2), PGK2(2) 26759011 27 26 27 6 8 4 3 5 7 0 0.0915 0.999 1.000 382 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(1) 14638961 21 20 20 8 6 1 5 6 3 0 0.627 0.999 1.000 383 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(1), CES1(2), DDHD1(3), ESCO1(4), ESCO2(1), NAT6(1) 15938151 13 13 13 4 2 0 2 6 3 0 0.696 0.999 1.000 384 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(1), CEBPB(1), CRY2(2), EIF4G2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(4), NCOA4(3), NR1D2(2), PER1(2), PER2(2), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(2), ZFR(1) 23033120 29 25 29 8 3 2 5 11 8 0 0.658 1.000 1.000 385 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(2), C3(2), C6(4), C8B(1), C9(2), MASP1(3) 13092940 14 14 14 5 4 1 3 4 2 0 0.572 1.000 1.000 386 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), POLD1(1), POLG(1) 7870560 3 3 3 5 1 1 0 0 1 0 0.994 1.000 1.000 387 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), CYP19A1(2), HEMK1(1), HSD11B1(1), HSD17B3(1), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2) 31646959 45 40 45 10 8 5 6 15 11 0 0.150 1.000 1.000 388 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CFLAR(1), DFFA(1), LMNA(2), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(2), TNFSF12(1), TRAF2(4) 21001997 18 17 18 4 4 5 2 5 2 0 0.251 1.000 1.000 389 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(2), C3(2), C6(4), C9(2) 11012540 10 10 10 5 2 1 2 3 2 0 0.797 1.000 1.000 390 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GPRC5B(1), GRM1(7), GRM3(2), GRM4(1), GRM5(3), GRM7(1), GRM8(2) 13250265 19 19 18 8 10 1 1 3 4 0 0.594 1.000 1.000 391 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 HMGCS1(1), LSS(1), SQLE(1) 8248968 3 3 3 6 1 0 0 1 1 0 0.998 1.000 1.000 392 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), CASP1(2), ITCH(1), MAGI2(1), RERE(2), WWP1(2) 15131799 9 9 9 3 2 1 1 3 2 0 0.658 1.000 1.000 393 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(5), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5), LDHC(1), MUT(1) 20896553 24 22 23 7 8 2 4 7 3 0 0.469 1.000 1.000 394 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(3), GLB1(1), HEXB(2), LCT(3), SLC33A1(1), ST3GAL1(2), ST6GALNAC4(1), ST8SIA1(1) 10405168 16 14 16 8 7 3 1 3 2 0 0.758 1.000 1.000 395 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(2), C3(2), C6(4), C9(2), MASP1(3), MASP2(1) 13407948 14 14 14 5 3 1 3 5 2 0 0.599 1.000 1.000 396 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), FCER1A(1), GRB2(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAPK1(1), NFATC1(1), NFATC2(2), PAK2(1), PIK3CA(12), PIK3R1(1), PLA2G4A(3), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3) 26829880 44 38 43 10 16 6 4 16 2 0 0.173 1.000 1.000 397 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL4(1), ITGAX(2), TLR4(1), TLR7(1), TLR9(1) 11747252 11 11 11 6 4 1 0 3 3 0 0.807 1.000 1.000 398 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IKBKB(1), RB1(2), RELA(2), TNF(1) 10893065 6 6 6 3 2 1 2 0 0 1 0.685 1.000 1.000 399 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2A1(1), CASP1(2), CD40(1), CD40LG(1), DAXX(1), DFFA(1), FAS(1), FASLG(1), IKBKE(1), MCL1(1), NR3C1(1), NTRK1(4), PTPN13(1), RIPK1(1), TFG(1), TNF(1), TRAF1(1), TRAF2(4) 27372393 26 23 26 5 9 6 2 5 4 0 0.112 1.000 1.000 400 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(5), DUSP1(1), EP300(5), IKBKB(1), MAP3K7(2), NR3C1(1), RELA(2), TGFBR1(2), TNF(1) 18683279 20 18 20 5 9 1 4 3 3 0 0.353 1.000 1.000 401 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5) 10548249 12 11 12 5 4 2 2 2 2 0 0.764 1.000 1.000 402 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 GRB2(1), IL3RA(2), RAF1(1), SHC1(2), SOS1(1), STAT5B(1) 10881437 8 8 8 4 4 2 2 0 0 0 0.708 1.000 1.000 403 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACADS(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH5A1(1), DDHD1(3), EHHADH(5), GAD1(2), GAD2(6), HADH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), ILVBL(2), PDHA2(3), RDH12(1) 25527900 39 37 38 11 14 6 5 7 7 0 0.231 1.000 1.000 404 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(1), RELN(4), VLDLR(2) 8854542 9 9 9 5 2 1 2 3 1 0 0.902 1.000 1.000 405 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP5A1(2), ATP5G3(1), ATP5J(1), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), COX7A1(1), COX7C(1), CYC1(1), NDUFA10(2), NDUFB10(2), NDUFB7(1), NDUFB9(1), NDUFS2(1), NDUFS3(1), NDUFV1(1), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1) 35104475 41 37 41 9 6 7 6 14 8 0 0.162 1.000 1.000 406 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), EBP(1), GGCX(1), HSD17B7(1), LSS(1), NQO1(1), SQLE(1), TM7SF2(1) 12055935 10 10 10 7 4 2 1 0 3 0 0.913 1.000 1.000 407 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), EHHADH(5), KMO(1), KYNU(3), MAOA(2), TDO2(1), TPH1(1), WARS(1) 34679565 56 50 55 14 18 5 8 14 11 0 0.244 1.000 1.000 408 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), JAK3(1), PIAS3(1), PTPRU(3), SOAT1(1) 8656734 9 8 9 6 2 1 1 4 1 0 0.959 1.000 1.000 409 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), ASPA(1), CNDP1(2), HAL(1), HDC(1), MAOA(2) 15328963 18 17 17 9 4 3 2 5 4 0 0.919 1.000 1.000 410 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG12(1), ALG14(2), ALG5(1), B4GALT1(2), B4GALT2(2), DPM1(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(3), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), ST6GAL1(1) 26535444 22 18 22 4 7 2 2 5 6 0 0.262 1.000 1.000 411 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), NTRK1(4), RAC1(1), WASF1(1), WASF2(1), WASF3(1) 9630885 10 10 10 6 0 5 1 3 1 0 0.898 1.000 1.000 412 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1), F10(2), F11(4), F12(1), F2(1), F2R(1), F5(4), F8(1), FGA(5), FGB(2), KLKB1(1), PROC(2), PROS1(2), SERPING1(1) 27844691 39 38 39 11 12 6 2 10 9 0 0.395 1.000 1.000 413 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(2), B4GALT2(2), G6PC2(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANC(2), GCK(4), GLB1(1), HK2(1), HK3(2), LCT(3), MGAM(6), PFKL(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), RDH12(1), UGP2(1) 24263061 39 34 38 10 16 3 4 9 7 0 0.0975 1.000 1.000 414 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(1), GRB2(1), MAP3K1(1), MAPK1(1), MAPK8IP3(3), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3), VAV2(2), VAV3(3) 19854274 27 25 27 9 10 2 3 9 3 0 0.495 1.000 1.000 415 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF2(1) 11511472 6 6 6 3 0 2 0 3 1 0 0.846 1.000 1.000 416 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), CDC16(1), CDC20(1), CDC23(1), CDC27(1), CUL2(3), CUL3(3), FBXW11(2), FZR1(2), ITCH(1), SMURF2(1), TCEB2(1), UBA1(1), VHL(2), WWP1(2) 25264267 30 29 30 8 2 3 8 10 7 0 0.437 1.000 1.000 417 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(1), GRB2(1), GSK3A(2), GSK3B(1), IL4R(3), IRS1(2), IRS2(2), JAK1(3), JAK3(1), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(2) 23046940 46 40 44 13 13 7 3 14 9 0 0.372 1.000 1.000 418 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(2), FASN(2) 9872549 9 9 9 7 1 1 1 5 1 0 0.979 1.000 1.000 419 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(2), ESCO1(4), ESCO2(1), GOT1(1), GOT2(1), HPD(1), LPO(1), MAOA(2), MPO(1), NAT6(1), TPO(3) 21480448 23 23 23 7 6 4 1 6 6 0 0.633 1.000 1.000 420 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(2), ARHGAP6(2), ARHGEF1(4), ARHGEF11(2), ARHGEF5(3), CFL1(1), DIAPH1(1), GSN(1), LIMK1(2), MYLK(4), PFN1(1), PIP5K1B(1), ROCK1(5), TLN1(2) 28327121 32 30 31 8 3 5 5 9 10 0 0.478 1.000 1.000 421 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(1), ARHGEF11(2), DLG4(1), GNA13(1), LPA(2), MAP2K4(3), MAP3K1(1), MAP3K5(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(3), PLD1(3), PLD2(1), PTK2(2), ROCK1(5), TBXA2R(2) 30951419 36 31 34 8 8 7 4 10 7 0 0.164 1.000 1.000 422 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(2), GAD2(6), GOT1(1), GOT2(1), PC(1) 16417070 18 18 18 9 5 3 2 3 5 0 0.868 1.000 1.000 423 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PLCG1(1), PRKCA(2), SYT1(1) 8672791 4 4 4 2 3 0 0 1 0 0 0.743 1.000 1.000 424 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(9), ATF2(2), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR2(1), CHRD(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), NPPA(1), RFC1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR3(1) 21938575 36 30 36 10 7 5 7 6 11 0 0.300 1.000 1.000 425 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(2), EGFR(3), GRB2(1), MAPK1(1), PTPRB(2), RAF1(1), SHC1(2), SOS1(1), SPRY3(1) 15462977 15 15 15 5 5 1 1 7 1 0 0.681 1.000 1.000 426 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(3), AKT2(1), BRD4(3), CAP1(1), CBL(1), CDKN2A(1), FLOT1(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(2), IRS4(3), LNPEP(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(3), SOS1(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 37056110 54 46 52 11 13 9 5 15 12 0 0.0931 1.000 1.000 427 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(2), ESR1(2), NR1D1(1), NR1D2(2), NR1I2(2), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR3C1(1), NR4A2(1), NR5A2(1), PGR(2), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(1), RXRB(3), RXRG(1), THRA(2) 26288353 34 30 33 9 19 2 5 3 5 0 0.193 1.000 1.000 428 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(1), BCR(1), BTK(1), CD81(2), DAG1(1), FLOT1(1), GRB2(1), GSK3A(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(7), ITPR3(3), MAP4K1(1), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PLCG2(2), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3) 46637650 72 65 70 17 23 8 9 20 12 0 0.0942 1.000 1.000 429 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(4), PRKAG1(2), PRKAR1A(1), PRKAR1B(2) 9650587 16 15 16 7 4 0 2 9 1 0 0.882 1.000 1.000 430 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), DFFA(1), LMNA(2), MADD(2), MAP2K4(3), MAP3K1(1), MAP3K7(2), PAK1(1), PAK2(1), PRKDC(7), RB1(2), RIPK1(1), SPTAN1(1), TNF(1), TRAF2(4) 24309009 30 27 30 8 13 3 2 7 4 1 0.350 1.000 1.000 431 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), GK(1), GLB1(1), LCT(3), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(1), PPAP2A(2), PPAP2B(1) 30232801 44 36 43 10 14 4 6 11 9 0 0.109 1.000 1.000 432 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(4), CPOX(1), EPRS(3), HMBS(1), HMOX2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2) 17309506 18 18 18 6 6 1 1 7 3 0 0.629 1.000 1.000 433 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), LDHC(1), ME1(2), ME3(1), PC(1), PDHA2(3) 23291823 23 23 22 7 6 3 3 8 3 0 0.430 1.000 1.000 434 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), NAGS(1), PYCR1(1) 10999717 12 12 12 7 6 0 1 4 1 0 0.865 1.000 1.000 435 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(2), HK2(1), HK3(2), MTMR2(2), MTMR6(1), NAGK(1), PGM3(2) 18055590 15 15 15 7 3 2 1 5 4 0 0.838 1.000 1.000 436 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), MAP3K1(1), MYC(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), RELA(2), SYT1(1) 17633832 15 14 15 5 5 1 2 6 1 0 0.530 1.000 1.000 437 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(3), ASAH1(1), CREB3(1), CREBBP(5), DAG1(1), EGR1(2), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK8IP3(3), NTRK1(4), PIK3C2G(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), SHC1(2), TERF2IP(1) 31260037 51 45 49 15 15 11 3 12 10 0 0.268 1.000 1.000 438 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), INPP5B(2), INPP5E(2), IPMK(1), ITPK1(2), ITPKB(2), OCRL(3), PI4KA(3), PI4KB(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB4(8), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), SYNJ1(3), SYNJ2(2) 46312831 69 60 68 15 18 14 8 23 6 0 0.0334 1.000 1.000 439 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), ALAS2(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CPT1B(1), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCG1(1), PLCG2(2), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1) 26292753 27 25 27 9 7 3 2 6 9 0 0.763 1.000 1.000 440 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(1), CD79A(1), GRB2(1), MAP3K1(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3) 23777020 23 22 23 6 12 1 3 7 0 0 0.323 1.000 1.000 441 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), PDE6B(1), PDE6C(1), PDE6D(1), SLC6A13(2), TF(1) 22523087 23 21 23 8 7 3 1 7 5 0 0.678 1.000 1.000 442 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1R(2), ETS1(1), ETV3(3), HDAC5(2), NCOR2(4), RBL2(2), SIN3B(1) 16012279 15 14 15 5 3 1 5 1 5 0 0.570 1.000 1.000 443 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 GRB2(1), MAP2K4(3), MAP3K1(1), NFATC1(1), NFATC2(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAC1(1), RAF1(1), RELA(2), SHC1(2), SOS1(1), SYT1(1), VAV1(3), ZAP70(3) 29834614 41 35 40 11 16 6 6 13 0 0 0.232 1.000 1.000 444 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BCL2L11(1), BIRC2(1), BIRC5(2), CASP1(2), DFFA(1), FAS(1), FASLG(1), HELLS(1), IKBKB(1), IRF2(1), IRF3(2), IRF4(2), IRF6(2), MAP2K4(3), MAP3K1(1), MDM2(1), MYC(1), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF21(4), TRAF1(1), TRAF2(4) 35580091 43 38 43 10 10 5 3 15 10 0 0.243 1.000 1.000 445 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(2), EIF2B2(1), EIF2B3(1), FLT1(3), FLT4(2), KDR(3), NOS3(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(2), SHC1(2), VHL(2) 21129245 38 30 37 10 16 6 2 8 6 0 0.289 1.000 1.000 446 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(3), AKT2(1), BTK(1), FCER1A(1), GAB2(5), GRB2(1), IL4(1), INPP5D(2), LCP2(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK12(1), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PRKCA(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(3), VAV2(2), VAV3(3) 45186371 82 70 80 20 25 12 8 26 11 0 0.0914 1.000 1.000 447 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(1), BCAR1(1), BCR(1), CAPNS1(1), CAV1(1), GRB2(1), ITGA1(1), MAPK1(1), PTK2(2), PXN(2), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(1), TLN1(2) 29401999 24 22 23 5 6 2 5 6 5 0 0.260 1.000 1.000 448 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(3), F2(1), F2RL3(1), MAPK1(1), PLD1(3), PLD2(1), PTK2(2), RAF1(1), RASAL1(2), VAV1(3) 17268021 20 18 20 7 9 2 1 6 2 0 0.629 1.000 1.000 449 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), CHRM2(2), CHRM4(1), DRD2(1), DRD3(1), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2) 16157160 32 30 32 12 15 4 2 8 3 0 0.369 1.000 1.000 450 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CALML6(1), CAMK2A(1), CAMK2D(1), CLCA1(1), CLCA2(1), CLCA4(1), CNGA3(1), CNGA4(3), CNGB1(1), GNAL(1), GUCA1A(1), PDE1C(3), PRKACA(2), PRKG1(2), PRKX(2) 19223351 23 23 23 9 7 5 3 4 4 0 0.471 1.000 1.000 451 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(1), ACO1(1), ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), PCK2(2), SDHA(1), SDHB(1), SDHC(2) 18262873 15 14 15 6 2 1 4 4 4 0 0.707 1.000 1.000 452 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1A(1), IRAK1(1), MAP3K1(1), MAP3K7(2), RELA(2), RIPK1(1), TLR4(1), TNF(1), TNFAIP3(1) 15211509 12 12 12 5 6 1 2 1 2 0 0.643 1.000 1.000 453 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(3), MAP3K1(1), MCL1(1), MDM2(1), MYC(1), PARP1(2), PRF1(1), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(4) 22990436 23 20 23 7 6 5 2 7 3 0 0.431 1.000 1.000 454 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(1), ASAH1(1), DAG1(1), DRD2(1), EGFR(3), EPHB2(3), GRB2(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PIK3CB(3), PITX2(1), PLCB1(3), PLCB4(8), RAF1(1), SHC1(2), SOS1(1), STAT3(6), TERF2IP(1) 35905417 56 52 55 15 11 13 3 20 9 0 0.241 1.000 1.000 455 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IKBKB(1), IL1A(1), IL1RAP(2), IL6(1), IRAK1(1), IRAK2(3), IRAK3(2), MAP3K1(1), MAP3K7(2), RELA(2), TGFB1(1), TGFB2(2), TNF(1) 18604520 21 20 21 8 10 2 3 3 3 0 0.603 1.000 1.000 456 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(1), ADCY1(2), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(2), RPS6KA1(1) 12643700 15 15 15 8 3 1 1 9 1 0 0.943 1.000 1.000 457 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR2A(2), ACVRL1(2), BMP4(1), BMP5(3), BMP6(1), BMP7(3), BMP8B(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CHRD(1), COMP(1), CREBBP(5), DCN(2), EP300(5), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(2), INHBE(2), LTBP1(4), MAPK1(1), MYC(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(5), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(5), SMAD6(2), SMAD9(1), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFB2(2), TGFBR1(2), THBS1(2), THBS3(1), THBS4(2), TNF(1), ZFYVE16(2), ZFYVE9(1) 62379130 91 79 89 19 22 10 18 27 14 0 0.0312 1.000 1.000 458 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPNS1(1), ITGA1(1), PTK2(2), PXN(2), RAC1(1), SPTAN1(1), TLN1(2) 17980408 11 11 11 4 3 1 1 4 2 0 0.686 1.000 1.000 459 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(2), GRIN2A(10), GRIN2B(6), GRIN2C(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), SYT1(1) 16080216 31 29 31 11 10 4 0 15 2 0 0.525 1.000 1.000 460 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 EPOR(1), GRB2(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1) 13194168 8 8 8 4 5 2 1 0 0 0 0.748 1.000 1.000 461 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CDS1(2), CHAT(2), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), ESCO1(4), ESCO2(1), ETNK1(1), GNPAT(1), GPAM(2), NAT6(1), PISD(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(2), PPAP2B(1) 41125184 50 44 50 10 11 5 4 14 16 0 0.126 1.000 1.000 462 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(1), GPX4(1), GPX6(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1), OPLAH(1) 13334694 12 12 12 5 2 2 2 5 1 0 0.690 1.000 1.000 463 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(1), EEF1A2(2), EEF1D(1), EEF2(2), EEF2K(4), EIF2AK3(4), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G3(2), EIF5B(1), PABPC3(1) 27601707 24 23 24 9 6 1 3 6 8 0 0.735 1.000 1.000 464 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CD8A(1), CD8B(2), HLA-A(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), KIR2DL1(1), KIR3DL1(2), NFYA(1), NFYC(2), PSME1(1), RFXAP(1), TAP1(2), TAP2(1) 29198885 33 30 33 10 5 7 6 7 8 0 0.348 1.000 1.000 465 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(3), APC(9), ASAH1(1), CAV3(1), DAG1(1), DLG4(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PITX2(1), RAC1(1), RYR1(13) 28849239 50 46 49 15 19 4 2 11 14 0 0.351 1.000 1.000 466 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(5), EP300(5), HDAC3(2), IKBKB(1), RELA(2), RIPK1(1), TNF(1) 14067959 17 17 17 7 7 2 4 3 1 0 0.657 1.000 1.000 467 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 GRB2(1), JAK1(3), JAK3(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2) 14281267 12 11 12 9 5 3 1 2 1 0 0.949 1.000 1.000 468 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), DAK(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), GK(1), GLB1(1), GPAM(2), LCT(3), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(1), PPAP2A(2), PPAP2B(1) 36849539 52 42 52 13 13 5 6 14 14 0 0.200 1.000 1.000 469 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLD1(1), POLD3(1), POLE(4), POLG(1), POLI(1), POLL(1), POLM(1), POLQ(5), PRIM2(1), REV1(1), REV3L(1), RFC5(1) 25520170 20 18 20 8 4 2 3 5 6 0 0.868 1.000 1.000 470 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(3), AKT2(1), CDKN1B(5), CDKN2A(1), CREB3(1), EBP(1), ERBB4(2), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(2), IRS4(3), MET(2), MYC(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(12), PIK3CD(4), PPP1R13B(1), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC1(1), TSC2(4), YWHAH(1), YWHAQ(1), YWHAZ(1) 48235541 66 56 64 16 15 10 4 18 19 0 0.227 1.000 1.000 471 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(2), ACOX3(1), ACSL1(2), ACSL6(2), ADIPOQ(1), AQP7(1), CPT1B(1), CPT1C(4), CYP7A1(1), CYP8B1(1), DBI(1), EHHADH(5), FABP2(1), FABP4(1), FABP6(1), GK(1), HMGCS2(1), LPL(1), ME1(2), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(1), PPARG(1), RXRB(3), RXRG(1), SCD(1), SLC27A1(1), SLC27A5(1), SLC27A6(1), SORBS1(3), UBC(1) 40391695 50 43 49 11 18 7 6 10 9 0 0.0928 1.000 1.000 472 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB3(1), EEF2K(4), EIF4E(1), GRB2(1), MAP3K8(1), MAPK1(1), RAP1A(1), RPS6KA1(1), SHC1(2), SOS1(1) 17645802 14 14 14 6 6 4 1 1 2 0 0.612 1.000 1.000 473 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), RDH12(1), SLC27A5(1), SOAT1(1), SOAT2(1) 19891666 20 19 20 9 5 1 5 6 3 0 0.783 1.000 1.000 474 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(3), AKT2(1), KDR(3), MAPK1(1), MAPK12(1), MAPKAPK3(1), NFATC1(1), NFATC2(2), NOS3(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PPP3CA(1), PPP3CC(1), PRKCA(2), PRKCG(1), PTGS2(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SHC2(1), SPHK2(1), VEGFA(2) 45031473 73 56 71 17 21 13 9 16 14 0 0.0511 1.000 1.000 475 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), ATP8A1(1), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CXCR6(1), EDNRA(1), FPR1(2), FSHR(1), GALT(1), GNRHR(3), LHCGR(1), MC3R(2), MC4R(1), NPY1R(1), NPY2R(2), NPY5R(1), NTSR1(1), OPRL1(1), OPRM1(2), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(2), TRHR(1), TSHR(1) 32966457 55 49 54 18 20 6 3 21 5 0 0.266 1.000 1.000 476 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(1), CACNA1A(10), GNA13(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GNAZ(3), GRIA2(4), GRIA3(1), GRID2(6), GRM1(7), GRM5(3), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IGF1R(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NOS1(3), NOS3(2), NPR1(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCB1(3), PLCB4(8), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(2), RAF1(1), RYR1(13) 66761312 115 94 114 24 48 10 7 31 19 0 0.00961 1.000 1.000 477 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), G6PC2(1), GCK(4), HK2(1), HK3(2), LDHAL6A(1), LDHC(1), PDHA2(3), PFKL(2), PFKM(2), PFKP(2), PGK2(2), PGM1(1), PGM3(2) 36654270 41 39 41 11 12 4 8 8 9 0 0.134 1.000 1.000 478 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(2), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), NME1(1), NT5E(1), NT5M(1), POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), TXNRD1(1), TYMS(1), UCK2(2), UMPS(1), UPP1(2) 36082762 42 37 41 11 12 4 10 10 6 0 0.240 1.000 1.000 479 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTB(1), ACTG1(2), ACVR1B(1), CDH1(4), CREBBP(5), CSNK2A2(1), CTNNA1(1), CTNNA2(4), CTNNA3(1), EGFR(3), EP300(5), ERBB2(3), FARP2(2), FER(1), FGFR1(2), IGF1R(2), IQGAP1(3), LEF1(2), LMO7(1), MAP3K7(2), MAPK1(1), MET(2), MLLT4(2), NLK(1), PTPN1(1), PTPRB(2), PTPRF(2), PTPRM(1), PVRL1(2), PVRL2(2), RAC1(1), RAC2(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(1), SORBS1(3), SSX2IP(1), TCF7L1(1), TCF7L2(3), TGFBR1(2), TJP1(1), WAS(1), WASF1(1), WASF2(1), WASF3(1) 74425132 90 78 89 17 24 10 13 30 13 0 0.0118 1.000 1.000 480 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), BCAR1(1), CAPN11(3), CAPN3(1), CAPN5(1), CAPN7(1), CAPNS1(1), CAV1(1), CAV3(1), CRK(1), DOCK1(2), GIT2(1), GRB2(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAM(2), ITGAV(3), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), MAPK12(1), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PDPK1(1), PIK3R2(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAPGEF1(3), ROCK1(5), SHC1(2), SHC3(1), SORBS1(3), SOS1(1), TLN1(2), TNS1(6), VAV2(2), VAV3(3) 84215094 110 88 108 21 25 16 10 41 18 0 0.00860 1.000 1.000 481 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(1), ATR(2), BAI1(5), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), FAS(1), GTSE1(2), MDM2(1), MDM4(2), PPM1D(1), RCHY1(1), SERPINB5(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(1), THBS1(2), TNFRSF10B(2), TSC2(4) 36128219 40 37 40 11 14 2 4 13 7 0 0.354 1.000 1.000 482 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(9), CCND3(1), CSNK1E(1), DVL2(2), DVL3(1), FZD1(2), FZD10(3), FZD2(4), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GSK3B(1), LDLR(1), MYC(1), PLAU(2), PPP2R5E(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(1), WNT5A(1), WNT6(2) 36848739 52 44 52 16 14 6 7 12 13 0 0.261 1.000 1.000 483 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(2), DUSP8(2), GCK(4), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K9(2), PAPPA(3), SHC1(2) 31233538 39 32 38 11 14 7 3 7 8 0 0.286 1.000 1.000 484 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(2), GCK(4), GYS1(2), HK2(1), HK3(2), MGAM(6), PGM1(1), PGM3(2), PYGL(2), SI(5), UGDH(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2) 35914046 48 43 47 13 11 5 11 10 11 0 0.287 1.000 1.000 485 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(4), AKT1(3), AKT2(1), ARAF(1), CAMK2A(1), CAMK2D(1), CBL(1), CDKN1A(2), CDKN1B(5), CRK(1), EGF(2), EGFR(3), ERBB2(3), ERBB3(4), ERBB4(2), GRB2(1), GSK3B(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MYC(1), NRG1(5), NRG2(4), NRG3(3), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), STAT5B(1) 63435423 106 83 104 27 34 15 10 26 21 0 0.0834 1.000 1.000 486 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(2), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), RAF1(1), SYT1(1) 21650903 20 17 20 8 6 0 3 11 0 0 0.765 1.000 1.000 487 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALML6(1), CDS1(2), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), IMPA1(1), INPP5B(2), INPP5D(2), INPP5E(2), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), OCRL(3), PI4KA(3), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB4(8), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(2) 77843226 113 88 112 23 30 22 10 32 19 0 0.00821 1.000 1.000 488 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), CCKBR(2), CCR2(3), CELSR1(2), CELSR2(6), CELSR3(2), CHRM2(2), EDNRA(1), EMR2(5), EMR3(1), F2R(1), FSHR(1), GHRHR(1), GNRHR(3), GPR116(1), GPR132(1), GPR133(2), GPR17(2), GPR18(1), GPR55(1), GPR56(1), GPR84(1), GRM1(7), LGR6(1), LPHN2(3), LPHN3(8), NTSR1(1), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2) 41896044 68 59 66 22 26 8 8 21 5 0 0.144 1.000 1.000 489 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), ACVRL1(2), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(1), BUB1(1), CDKL2(3), CDS1(2), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A2(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), IMPA1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(3), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CG(4), PLCB1(3), PLCB4(8), PLCG1(1), PLCG2(2), PLK3(3), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(2), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2) 70929660 104 78 102 22 26 20 16 29 13 0 0.0148 1.000 1.000 490 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(2), CANT1(2), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD4(1), ENTPD6(3), NME1(1), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), POLA1(1), POLD1(1), POLD3(1), POLE(4), POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1), PRIM2(1), RFC5(1), TXNRD1(1), TYMS(1), UCK2(2), UMPS(1), UPP1(2) 50915042 55 51 54 14 16 5 10 16 8 0 0.211 1.000 1.000 491 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOX1(2), BCAT1(1), BCKDHA(1), DBT(1), EHHADH(5), HADH(1), HADHB(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), IVD(2), MCCC1(1), MUT(1) 27107735 33 33 32 11 10 6 3 7 7 0 0.513 1.000 1.000 492 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(3), AKT2(1), CAB39(1), DDIT4(1), FIGF(1), MAPK1(1), PDPK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PRKAA2(4), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), TSC1(1), TSC2(4), ULK3(1), VEGFA(2) 32463515 53 47 51 16 15 11 7 13 7 0 0.275 1.000 1.000 493 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ARHGAP5(2), BCAR1(1), CDH5(5), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CTNNA1(1), CTNNA2(4), CTNNA3(1), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGA4(2), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MAPK12(1), MLLT4(2), MMP9(2), MSN(1), MYL5(1), NCF1(1), NCF2(3), NCF4(1), NOX3(4), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(1), RAPGEF4(2), RASSF5(1), ROCK1(5), SIPA1(2), VAV1(3), VAV2(2), VAV3(3), VCAM1(1) 77050622 114 91 112 29 34 13 14 32 21 0 0.111 1.000 1.000 494 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(5), CTBP2(1), DLL1(1), DLL3(3), DLL4(2), DTX1(3), DTX2(1), DTX3L(1), DTX4(2), DVL2(2), DVL3(1), EP300(5), JAG2(3), LFNG(1), MAML1(1), MAML2(1), MAML3(1), MFNG(1), NCOR2(4), NCSTN(1), NOTCH1(3), NOTCH2(4), NOTCH3(3), NOTCH4(3), NUMB(1), NUMBL(1), PTCRA(1), RBPJL(1), SNW1(2) 43537140 59 50 59 18 22 7 7 9 14 0 0.330 1.000 1.000 495 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(3), AKT2(1), BCR(1), BTK(1), CDKN2A(1), FLOT1(1), ITPR1(2), ITPR2(7), ITPR3(3), PDK1(1), PIK3CA(12), PITX2(1), PLCG2(2), PPP1R13B(1), PTPRC(7), RPS6KA1(1), SAG(2), SYK(2), VAV1(3) 34283851 52 49 50 16 10 8 7 17 10 0 0.451 1.000 1.000 496 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(1), BLVRB(1), COX15(1), CP(4), CPOX(1), EPRS(3), FTMT(1), HMBS(1), HMOX2(1), MMAB(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2) 26592912 34 30 34 11 9 2 3 14 6 0 0.596 1.000 1.000 497 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(4), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC20(1), CDC25A(1), CDC25B(2), CDC6(1), CDC7(2), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(2), E2F3(1), EP300(5), ESPL1(2), GSK3B(1), HDAC3(2), HDAC5(2), HDAC6(3), HDAC8(2), MAD1L1(2), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MPEG1(5), PCNA(1), PRKDC(7), PTPRA(3), RB1(2), SMAD4(5), TFDP1(1), TGFB1(1) 64393049 84 65 84 17 23 11 12 24 13 1 0.0262 1.000 1.000 498 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(2), ADCY8(5), ARAF(1), ATF4(1), CACNA1C(2), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(5), EP300(5), GRIA2(4), GRIN1(2), GRIN2A(10), GRIN2B(6), GRIN2C(1), GRM1(7), GRM5(3), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), PLCB1(3), PLCB4(8), PPP1CA(1), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1) 59968118 99 85 98 28 32 11 5 34 17 0 0.230 1.000 1.000 499 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(1), ADCY9(3), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(2), PRKCA(2), SEC61A1(1), SEC61A2(1) 23268630 29 29 29 10 6 4 2 12 5 0 0.532 1.000 1.000 500 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(2), FUK(1), GMDS(1), GMPPB(1), HK2(1), HK3(2), MPI(1), MTMR2(2), MTMR6(1), PFKFB1(2), PFKFB4(1), PFKL(2), PFKM(2), PFKP(2), PGM2(2), PMM1(1), RDH12(1), TSTA3(2) 23297037 27 25 27 10 5 2 4 9 7 0 0.483 1.000 1.000 501 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(1), CABIN1(1), CAMK4(2), CD69(2), CDKN1A(2), CEBPB(1), CNR1(3), CREBBP(5), EGR3(1), EP300(5), FCER1A(1), GSK3A(2), GSK3B(1), IFNB1(1), IL10(1), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(3), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), NUP214(1), PAK1(1), PPP3CC(1), PTPRC(7), RELA(2), SP1(2), SP3(3), TGFB1(1), TNF(1), TRAF2(4), TRPV6(2), VAV1(3), VAV2(2), VAV3(3), XPO5(1) 57104032 78 63 78 22 26 9 7 25 11 0 0.204 1.000 1.000 502 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(5), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), GOT2(1), HEMK1(1), HGD(1), HPD(1), LCMT2(1), MAOA(2), METTL6(1), NAT6(1), PNMT(1), PRMT3(2), PRMT5(2), PRMT8(1), TPO(3), TYR(2), TYRP1(1) 37405055 44 41 44 15 12 4 4 12 12 0 0.612 1.000 1.000 503 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(2), ACSL1(2), ACSL6(2), ADIPOQ(1), ADIPOR1(1), ADIPOR2(1), AKT1(3), AKT2(1), CPT1B(1), CPT1C(4), G6PC2(1), IKBKB(1), IRS1(2), IRS2(2), IRS4(3), JAK1(3), JAK3(1), LEPR(1), NFKBIB(1), NFKBIE(1), PCK2(2), POMC(2), PPARA(2), PPARGC1A(3), PRKAA2(4), PRKAG1(2), PRKAG3(1), PRKCQ(1), RELA(2), RXRB(3), RXRG(1), SLC2A1(1), STAT3(6), TNF(1), TRAF2(4), TYK2(1) 52219562 70 55 68 19 24 10 9 17 10 0 0.120 1.000 1.000 504 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(2), B3GALNT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT3(1), B3GNT4(2), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(2), PIGA(1), PIGB(2), PIGH(1), PIGO(2), PIGQ(3), ST3GAL1(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1) 30548373 39 34 39 13 13 4 5 11 5 1 0.531 1.000 1.000 505 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(4), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), ATR(2), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25A(1), CDC25B(2), CDC27(1), CDC6(1), CDC7(2), CDK7(1), CDKN1A(2), CDKN1B(5), CDKN2A(1), CREBBP(5), DBF4(1), E2F3(1), EP300(5), ESPL1(2), FZR1(2), GSK3B(1), MAD1L1(2), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), PCNA(1), PRKDC(7), RB1(2), RBL2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(1), SMC1B(1), TFDP1(1), TGFB1(1), TGFB2(2), YWHAH(1), YWHAQ(1), YWHAZ(1) 81002792 100 76 100 23 25 8 21 24 21 1 0.0745 1.000 1.000 506 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(4), ACTR3(1), AKT1(3), AKT2(1), ARHGEF6(1), ARHGEF7(1), BCAR1(1), CAV1(1), CDKN2A(1), CRK(1), CSE1L(1), DOCK1(2), EPHB2(3), GRB2(1), GRB7(2), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), MAP2K4(3), MAP2K7(3), MAP3K11(2), MAPK1(1), MAPK8IP3(3), MRAS(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PIK3CA(12), PIK3CB(3), PLCG1(1), PLCG2(2), PTK2(2), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(3), WAS(1) 75536800 106 80 103 27 22 18 13 32 21 0 0.0984 1.000 1.000 507 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CDS1(2), CHAT(2), CPT1B(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(1), LGALS13(1), PISD(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PPAP2A(2), PPAP2B(1) 31278408 35 30 35 12 8 4 6 7 10 0 0.556 1.000 1.000 508 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(5), EP300(5), ERCC3(1), ESR1(2), GRIP1(3), HDAC3(2), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(4), NRIP1(2), PELP1(2), POLR2A(3) 28697221 37 30 37 14 15 4 4 7 7 0 0.540 1.000 1.000 509 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), CARS(1), CARS2(2), DARS2(1), EPRS(3), FARSB(2), GARS(1), IARS(1), KARS(1), LARS(2), LARS2(2), MARS2(1), NARS2(1), PARS2(2), QARS(1), SARS(1), TARS(1), TARS2(2), VARS(3), VARS2(2), WARS(1), YARS2(2) 34204104 35 27 35 10 13 3 3 9 7 0 0.510 1.000 1.000 510 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(5), EHMT2(1), HADH(1), HSD17B4(3), NSD1(2), PLOD1(1), PLOD3(2), RDH12(1), SETD1A(2), SETDB1(2), SHMT1(1), SHMT2(1) 36462542 36 32 36 12 11 6 6 7 6 0 0.454 1.000 1.000 511 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR3(1), AKT1(3), AKT2(1), ARHGEF11(2), BTK(1), CFL1(1), ITPR1(2), ITPR2(7), ITPR3(3), LIMK1(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3CG(4), PIK3R1(1), PITX2(1), PPP1R13B(1), RACGAP1(1), ROCK1(5), SAG(2), WASF1(1) 43627396 69 62 66 22 15 10 7 22 15 0 0.596 1.000 1.000 512 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), DMD(3), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH6(6), MYH7(4), MYH8(5), MYL1(1), MYOM1(3), NEB(7), TCAP(2), TNNI1(1), TNNT3(1), TPM1(1), TPM4(1), TTN(66) 85441606 110 87 110 26 31 12 18 31 17 1 0.0661 1.000 1.000 513 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AKT1(3), AKT2(1), APAF1(1), BIRC2(1), CFLAR(1), DFFA(1), FAS(1), FASLG(1), IKBKB(1), IL1A(1), IL1RAP(2), IL3RA(2), IRAK1(1), IRAK2(3), IRAK3(2), IRAK4(1), NTRK1(4), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), TRAF2(4) 47987556 75 64 73 24 22 15 8 21 9 0 0.301 1.000 1.000 514 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(3), IGSF5(1), IKBKB(1), JAM2(1), MAP2K4(3), MAPK12(1), MET(2), NOD1(3), PAK1(1), PLCG1(1), PLCG2(2), RAC1(1), RELA(2), TJP1(1) 44222150 41 37 41 13 7 7 5 15 7 0 0.511 1.000 1.000 515 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(1), ACTG1(2), AKT1(3), AKT2(1), ARHGAP5(2), BCAR1(1), BIRC2(1), CAV1(1), CAV3(1), CCND3(1), COL11A2(5), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), CRK(1), DIAPH1(1), DOCK1(2), EGF(2), EGFR(3), ERBB2(3), FARP2(2), FIGF(1), FLNA(1), FLNB(1), FLNC(3), FLT1(3), FN1(4), GRB2(1), GSK3B(1), HGF(3), IGF1R(2), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAV(3), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), KDR(3), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), MAPK1(1), MET(2), MYL5(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PARVB(1), PARVG(2), PDGFA(1), PDGFD(2), PDGFRA(2), PDGFRB(1), PDPK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1C(2), PPP1CA(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(3), RELN(4), ROCK1(5), SHC1(2), SHC2(1), SHC3(1), SOS1(1), THBS1(2), THBS3(1), THBS4(2), TLN1(2), TLN2(3), TNC(2), TNN(3), TNXB(9), VAV1(3), VAV2(2), VAV3(3), VEGFA(2), VWF(4) 228120743 293 188 289 93 91 45 24 83 50 0 0.0781 1.000 1.000 516 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY8(5), ADCY9(3), ADORA2A(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(2), ATP2A1(3), ATP2A2(1), ATP2B1(1), ATP2B2(5), ATP2B3(2), ATP2B4(4), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1F(2), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(4), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CYSLTR1(1), CYSLTR2(1), EDNRA(1), EGFR(3), ERBB2(3), ERBB3(4), ERBB4(2), F2R(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2A(10), GRIN2C(1), GRM1(7), GRM5(3), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), LHCGR(1), MYLK(4), MYLK2(4), NOS1(3), NOS3(2), NTSR1(1), P2RX1(1), PDE1B(1), PDE1C(3), PDGFRA(2), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(3), PLCB1(3), PLCB4(8), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TBXA2R(2), TRHR(1), VDAC1(1) 168699620 273 179 271 109 107 29 19 74 44 0 0.632 1.000 1.000 517 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADORA1(2), ADORA2A(1), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2B(1), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(2), CHRM4(1), CNR1(3), CNR2(1), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), EDNRA(1), F2(1), F2R(1), F2RL3(1), FPR1(2), FSHR(1), GABBR2(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(4), GABRB2(2), GABRB3(1), GABRD(2), GABRE(2), GABRG1(4), GABRG2(1), GABRP(1), GABRQ(1), GABRR1(1), GABRR2(3), GH1(2), GH2(1), GHR(1), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(4), GPR83(2), GRIA2(4), GRIA3(1), GRIA4(4), GRID1(4), GRID2(6), GRIK1(2), GRIK2(1), GRIK3(5), GRIK4(2), GRIK5(1), GRIN1(2), GRIN2A(10), GRIN2B(6), GRIN2C(1), GRIN3A(2), GRIN3B(1), GRM1(7), GRM3(2), GRM4(1), GRM5(3), GRM6(1), GRM7(1), GRM8(2), GZMA(1), HCRTR2(4), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LEPR(1), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(1), NPY2R(2), NPY5R(1), NR3C1(1), NTSR1(1), OPRL1(1), OPRM1(2), P2RX1(1), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PRLR(1), PTGIR(2), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), SSTR5(1), TAAR2(1), TAAR5(1), TAAR6(3), TAAR8(3), TACR1(1), TACR3(2), TBXA2R(2), THRA(2), TRHR(1), TRPV1(1), TSHR(1), VIPR1(1) 138558880 259 179 255 72 114 30 17 68 30 0 0.000815 1.000 1.000 518 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 APC(9), APC2(1), ARAF(1), ARHGEF1(4), ARHGEF6(1), ARHGEF7(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(2), BDKRB2(1), CD14(1), CFL1(1), CHRM2(2), CHRM4(1), CRK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), DOCK1(2), EGF(2), EGFR(3), F2(1), F2R(1), FGD1(1), FGD3(2), FGF10(1), FGF16(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(2), FGFR3(1), FN1(4), GNA13(1), GSN(1), IQGAP1(3), IQGAP2(1), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAM(2), ITGAV(3), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), LIMK1(2), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(6), MYH9(2), MYL5(1), MYLK(4), MYLK2(4), NCKAP1L(5), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDGFA(1), PDGFRA(2), PDGFRB(1), PFN1(1), PFN2(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), ROCK1(5), RRAS2(1), SLC9A1(1), SOS1(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(4), TIAM2(4), VAV1(3), VAV2(2), VAV3(3), WAS(1), WASF1(1), WASF2(1) 172299869 241 177 238 59 67 30 23 82 39 0 0.0110 1.000 1.000 519 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(1), AKT1(3), AKT2(1), ATF2(2), ATF4(1), BDNF(1), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1F(2), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(4), CACNA2D1(2), CACNA2D3(1), CACNA2D4(2), CACNB1(3), CACNB2(2), CACNB4(2), CACNG3(1), CACNG4(1), CACNG5(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(2), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP7(1), DUSP8(2), ECSIT(2), EGF(2), EGFR(3), FAS(1), FASLG(1), FGF10(1), FGF16(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(2), FGFR3(1), FLNA(1), FLNB(1), FLNC(3), GRB2(1), IKBKB(1), IL1A(1), JUND(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K8(1), MAP4K1(1), MAPK1(1), MAPK12(1), MAPK8IP3(3), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), MYC(1), NF1(2), NFATC2(2), NLK(1), NTRK1(4), PAK1(1), PAK2(1), PDGFA(1), PDGFRA(2), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PPM1A(1), PPM1B(1), PPP3CA(1), PPP3CC(1), PPP5C(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(1), PTPN7(1), RAC1(1), RAC2(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK3(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(2), TGFBR1(2), TNF(1), TRAF2(4) 177403416 216 154 215 85 74 25 23 58 36 0 0.784 1.000 1.000 520 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(2), ATP1B2(1), ATP2A2(1), ATP2B1(1), ATP2B2(5), ATP2B3(2), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1S(4), CACNB1(3), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM2(2), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB2(1), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(3), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK4(1), GRK6(1), ITPR1(2), ITPR2(7), ITPR3(3), KCNB1(4), KCNJ5(1), MIB1(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS11(1), RGS16(2), RGS3(1), RGS6(2), RGS9(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SLC8A3(3), YWHAH(1), YWHAQ(1) 117650764 187 136 187 81 84 14 11 49 29 0 0.869 1.000 1.000 521 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(1), ACTG1(2), COL11A2(5), COL17A1(3), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), DSC1(1), DSC3(1), DSG1(1), DSG2(3), FN1(4), GJA1(1), GJA4(1), GJA5(2), GJA8(4), GJB2(1), GJB4(1), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT12(1), KRT14(1), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT23(2), KRT24(1), KRT25(4), KRT27(2), KRT28(1), KRT3(1), KRT31(2), KRT33A(1), KRT38(2), KRT39(1), KRT4(2), KRT5(1), KRT6A(1), KRT6C(4), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(4), KRT79(2), KRT83(1), KRT84(1), KRT85(3), KRT9(1), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), LMNA(2), NES(3), RELN(4), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(3), TNXB(9), VWF(4) 153950717 195 135 194 64 82 27 7 41 38 0 0.104 1.000 1.000 522 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(1), COL11A2(5), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), DAG1(1), FN1(4), FNDC1(5), FNDC3A(1), GP5(3), GP9(1), HSPG2(9), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAV(3), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), RELN(4), SDC3(1), SV2A(3), SV2B(2), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(3), TNXB(9), VWF(4) 138236305 173 127 172 53 64 24 8 42 35 0 0.0875 1.000 1.000 523 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(2), BMP7(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL11(1), CCL14(1), CCL17(1), CCL21(1), CCL28(1), CCL7(1), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CCR9(1), CD27(1), CD40(1), CD40LG(1), CNTF(1), CSF1R(2), CSF2RA(3), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EGF(2), EGFR(3), EPOR(1), FAS(1), FASLG(1), FLT1(3), FLT3(1), FLT3LG(1), FLT4(2), GH1(2), GH2(1), GHR(1), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(3), IL17RB(1), IL1A(1), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL24(1), IL25(1), IL26(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL6ST(6), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBC(2), INHBE(2), KDR(3), LEPR(1), LIFR(2), LTBR(2), MET(2), PDGFRA(2), PDGFRB(1), PF4(1), PRLR(1), TGFB1(1), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), TNFRSF11B(2), TNFRSF13B(2), TNFRSF18(2), TNFRSF21(4), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(2), TNFSF11(1), TNFSF12(1), TNFSF14(1), TNFSF15(1), TNFSF8(1), TPO(3), VEGFA(2), XCL1(1), XCR1(1) 111407361 165 116 165 45 46 19 21 51 28 0 0.0388 1.000 1.000 524 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(4), ABLIM1(2), CFL1(1), DCC(2), DPYSL2(1), DPYSL5(1), EFNA3(1), EFNA5(1), EFNB3(1), EPHA1(2), EPHA2(1), EPHA3(5), EPHA4(1), EPHA5(1), EPHA6(1), EPHA7(2), EPHA8(1), EPHB1(4), EPHB2(3), EPHB3(3), FES(3), GNAI1(1), GNAI2(1), GSK3B(1), L1CAM(6), LIMK1(2), LIMK2(3), LRRC4C(3), MAPK1(1), MET(2), NFATC1(1), NFATC2(2), NGEF(1), NRP1(1), NTN1(1), NTNG1(3), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(1), PLXNB1(2), PLXNB2(1), PLXNC1(3), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RAC3(1), RGS3(1), RHOD(1), ROBO1(6), ROBO2(5), ROBO3(1), ROCK1(5), SEMA3A(2), SEMA3C(2), SEMA3D(3), SEMA3E(2), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4C(2), SEMA4F(1), SEMA5A(1), SEMA5B(2), SEMA6A(1), SEMA6C(3), SEMA6D(2), SEMA7A(1), SLIT1(2), SLIT2(1), SLIT3(4), SRGAP1(4), SRGAP3(1), UNC5A(1), UNC5B(4), UNC5D(2) 123471354 157 113 156 51 57 13 17 51 19 0 0.329 1.000 1.000 525 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(9), APC2(1), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(5), CSNK1A1L(1), CSNK1E(1), CSNK2A2(1), CTBP2(1), CXXC4(1), DAAM1(2), DAAM2(3), DKK1(2), DKK2(2), DVL2(2), DVL3(1), EP300(5), FBXW11(2), FZD1(2), FZD10(3), FZD2(4), FZD4(2), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GSK3B(1), LEF1(2), LRP5(2), LRP6(1), MAP3K7(2), MYC(1), NFATC1(1), NFATC2(2), NKD2(1), NLK(1), PLCB1(3), PLCB4(8), PPARD(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE1(1), PRICKLE2(4), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), RAC3(1), ROCK1(5), SFRP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(3), VANGL2(2), WIF1(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 100496947 146 112 144 44 40 21 18 35 32 0 0.182 1.000 1.000 526 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(5), ACACB(2), AKT1(3), AKT2(1), ARAF(1), CALML6(1), CBL(1), CRK(1), FASN(2), FLOT1(1), G6PC2(1), GCK(4), GRB2(1), GSK3B(1), GYS1(2), IKBKB(1), INPP5D(2), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), PCK2(2), PDE3B(1), PDPK1(1), PFKL(2), PFKM(2), PFKP(2), PHKA1(1), PHKA2(1), PHKB(3), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PPARGC1A(3), PPP1CA(1), PPP1R3A(5), PPP1R3B(2), PRKAA2(4), PRKACA(2), PRKAG1(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(2), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(2), PYGL(2), RAF1(1), RAPGEF1(3), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOCS4(1), SORBS1(3), SOS1(1), TRIP10(1), TSC1(1), TSC2(4) 99371944 134 110 131 36 41 20 18 36 19 0 0.0440 1.000 1.000 527 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(1), ACTG1(2), AKT1(3), AKT2(1), ASH1L(7), CGN(2), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CSNK2A2(1), CTNNA1(1), CTNNA2(4), CTNNA3(1), CTTN(1), EPB41L1(2), EPB41L2(3), EXOC4(2), GNAI1(1), GNAI2(1), IGSF5(1), INADL(4), JAM2(1), LLGL1(1), LLGL2(1), MAGI2(1), MAGI3(1), MLLT4(2), MPDZ(2), MRAS(1), MYH1(4), MYH10(6), MYH11(5), MYH13(5), MYH15(3), MYH2(2), MYH4(8), MYH6(6), MYH7(4), MYH7B(4), MYH8(5), MYH9(2), MYL5(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), RRAS2(1), SPTAN1(1), TJAP1(2), TJP1(1), TJP2(4), TJP3(3), VAPA(2) 119092075 140 109 139 41 49 16 10 38 27 0 0.118 1.000 1.000 528 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(2), ADORA2A(1), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CCR9(1), CCRL2(1), CHRM2(2), CHRM4(1), CMKLR1(1), CNR1(3), CNR2(1), DRD2(1), DRD3(1), EDNRA(1), F2R(1), F2RL3(1), FPR1(2), FSHR(1), GALT(1), GPR17(2), GPR174(1), GPR35(1), GPR37(1), GPR37L1(3), GPR4(1), GPR50(4), GPR6(1), GPR83(2), GPR87(3), HCRTR2(4), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(1), NPY2R(2), NPY5R(1), NTSR1(1), OPRL1(1), OPRM1(2), OR12D3(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGIR(2), RGR(1), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(1) 76526400 134 108 133 46 54 19 8 41 12 0 0.104 1.000 1.000 529 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ATF2(2), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(3), CREB3(1), DGKZ(2), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK4(1), GRK6(1), GSTO1(2), GUCY1A3(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(2), ITPR2(7), ITPR3(3), MAFF(1), MIB1(1), MYLK2(4), NOS1(3), NOS3(2), PDE4D(1), PLCG1(1), PLCG2(2), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP1(1), RAMP2(1), RGS11(1), RGS16(2), RGS3(1), RGS6(2), RGS9(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SP1(2), TNXB(9), YWHAH(1), YWHAQ(1) 108701041 148 107 148 72 56 18 9 37 28 0 0.972 1.000 1.000 530 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(2), CADM3(3), CD226(1), CD276(1), CD34(1), CD40(1), CD40LG(1), CD8A(1), CD8B(2), CDH1(4), CDH2(2), CDH3(3), CDH4(5), CDH5(5), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CNTN2(1), CNTNAP1(7), CNTNAP2(1), ESAM(1), GLG1(2), HLA-A(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(1), ICAM2(1), ICAM3(1), ITGA4(2), ITGA6(2), ITGA8(2), ITGA9(3), ITGAL(3), ITGAM(2), ITGAV(3), ITGB2(2), ITGB8(1), JAM2(1), L1CAM(6), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEGR1(1), NEO1(2), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(3), NRXN1(3), NRXN2(2), NRXN3(3), PDCD1(1), PTPRC(7), PTPRF(2), PTPRM(1), PVRL1(2), PVRL2(2), SDC3(1), SELE(1), SELP(3), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3) 92676522 139 106 136 44 48 21 14 34 22 0 0.172 1.000 1.000 531 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(1), CBL(1), CCND3(1), CNTF(1), CREBBP(5), CSF2RA(3), CSF3R(1), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL24(1), IL26(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL6ST(6), IL7(1), IL7R(1), IL9(1), JAK1(3), JAK3(1), LEPR(1), LIFR(2), MYC(1), PIAS3(1), PIAS4(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PRLR(1), SOCS4(1), SOCS5(2), SOS1(1), SPRED2(2), SPRY3(1), STAT1(1), STAT2(1), STAT3(6), STAT4(4), STAT5B(1), STAT6(2), TPO(3), TYK2(1) 91640557 132 102 130 31 32 18 18 41 23 0 0.0300 1.000 1.000 532 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), AK5(1), AK7(1), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), APRT(1), ATIC(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD4(1), ENTPD6(3), FHIT(1), GART(1), GMPR(2), GMPR2(1), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IMPDH2(2), NME1(1), NPR1(1), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), PAPSS2(1), PDE10A(3), PDE1C(3), PDE2A(2), PDE3B(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6D(1), PDE7A(2), PDE8A(3), PDE8B(1), PDE9A(2), POLA1(1), POLD1(1), POLD3(1), POLE(4), POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1), PPAT(1), PRIM2(1), PRPS1L1(3), RFC5(1) 102792895 116 100 115 42 41 17 12 30 16 0 0.451 1.000 1.000 533 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ADRB1(1), DRD2(1), EGF(2), EGFR(3), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRB2(1), GRM1(7), GRM5(3), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), HTR2A(2), HTR2B(2), HTR2C(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NPR1(1), PDGFA(1), PDGFD(2), PDGFRA(2), PDGFRB(1), PLCB1(3), PLCB4(8), PRKACA(2), PRKCA(2), PRKCG(1), PRKG1(2), PRKX(2), RAF1(1), SOS1(1), TJP1(1), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1) 83033083 111 89 110 38 41 14 4 36 16 0 0.386 1.000 1.000 534 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ATF4(1), CACNA1C(2), CACNA1D(4), CACNA1F(2), CACNA1S(4), CALML6(1), CAMK2A(1), CAMK2D(1), CGA(1), EGFR(3), GNAS(2), GNRHR(3), GRB2(1), ITPR1(2), ITPR2(7), ITPR3(3), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK12(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCB1(3), PLCB4(8), PLD1(3), PLD2(1), PRKACA(2), PRKCA(2), PRKX(2), RAF1(1), SOS1(1) 79261765 96 81 96 37 28 15 4 32 17 0 0.730 1.000 1.000 535 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), AMY2B(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(4), DDX41(1), DDX47(3), DDX50(3), DDX56(1), ENPP1(2), ENPP3(1), ENTPD7(1), EP400(1), ERCC2(3), ERCC3(1), G6PC2(1), GAA(1), GANC(2), GBE1(2), GCK(4), GYS1(2), HK2(1), HK3(2), MGAM(6), MOV10L1(1), PGM1(1), PGM3(2), PYGL(2), RAD54B(3), RAD54L(1), RUVBL2(2), SETX(3), SI(5), SKIV2L2(3), SMARCA2(2), SMARCA5(3), TREH(1), UGDH(2), UGP2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2) 78045990 103 80 102 29 21 13 23 28 18 0 0.189 1.000 1.000 536 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), CALML6(1), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(2), CREB3L3(1), CREB3L4(1), CREBBP(5), DVL2(2), DVL3(1), EP300(5), FZD1(2), FZD10(3), FZD2(4), FZD4(2), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), LEF1(2), MAPK1(1), PLCB1(3), PLCB4(8), POMC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(3), TYR(2), TYRP1(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 67338783 99 80 99 43 34 19 8 23 15 0 0.652 1.000 1.000 537 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), CD48(3), FAS(1), FASLG(1), GRB2(1), HLA-A(1), HLA-G(1), ICAM2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(2), LCP2(1), MAPK1(1), MICB(1), NCR1(1), NCR2(1), NFATC1(1), NFATC2(2), PAK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(2), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), VAV1(3), VAV2(2), VAV3(3), ZAP70(3) 70122760 101 77 100 34 34 13 12 28 14 0 0.396 1.000 1.000 538 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), AK5(1), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), APRT(1), ATIC(2), ATP5A1(2), ATP5G3(1), ATP5J(1), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IMPDH2(2), NME1(1), NPR1(1), NT5E(1), NT5M(1), PAPSS2(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(1), PDE8A(3), PDE9A(2), POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), PPAT(1), PRPS1L1(3) 80761676 89 77 88 36 27 13 14 22 13 0 0.716 1.000 1.000 539 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), AKAP1(2), AKAP11(2), AKAP12(5), AKAP3(2), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(5), ARHGEF1(4), GNA13(1), GNAI2(1), GNAL(1), GNAO1(1), GNAZ(3), GNB1(1), GNB3(1), GNB5(1), GNGT1(1), ITPR1(2), PDE1B(1), PDE1C(3), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(2), PDE8A(3), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(1), SLC9A1(1) 73421508 86 67 86 34 29 11 7 27 12 0 0.660 1.000 1.000 540 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(1), ABCA12(4), ABCA13(9), ABCA3(1), ABCA4(3), ABCA5(5), ABCA7(2), ABCA8(1), ABCA9(5), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(2), ABCB6(1), ABCB7(1), ABCB9(1), ABCC10(2), ABCC11(4), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), CFTR(1), TAP1(2), TAP2(1) 74223250 79 66 79 38 22 15 12 15 15 0 0.848 1.000 1.000 541 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(1), CD14(1), CD40(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IKBKB(1), IKBKE(1), IL12A(1), IL12B(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(2), LY96(1), MAP2K4(3), MAP2K7(3), MAP3K7(2), MAP3K8(1), MAPK1(1), MAPK12(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), RAC1(1), RELA(2), RIPK1(1), STAT1(1), TBK1(1), TLR4(1), TLR5(2), TLR7(1), TLR8(2), TLR9(1), TNF(1) 56565535 78 66 76 25 21 12 11 20 14 0 0.345 1.000 1.000 542 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(1), CARD11(2), CBL(1), CD40LG(1), CD8A(1), CD8B(2), GRB2(1), IKBKB(1), IL10(1), IL4(1), ITK(1), LCP2(1), MAP3K8(1), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(7), SOS1(1), TNF(1), VAV1(3), VAV2(2), VAV3(3), ZAP70(3) 63725721 83 66 81 25 27 12 9 26 9 0 0.232 1.000 1.000 543 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(2), BDKRB2(1), C1S(2), C3(2), C3AR1(1), C4BPA(1), C6(4), C8B(1), C9(2), CD46(2), CFB(2), CFH(7), CFI(1), CPB2(1), CR1(1), F10(2), F11(4), F12(1), F13A1(2), F13B(2), F2(1), F2R(1), F3(1), F5(4), F7(2), F8(1), FGA(5), FGB(2), KLKB1(1), MASP1(3), MASP2(1), PLAT(2), PLAU(2), PLG(1), PROC(2), PROS1(2), SERPIND1(2), SERPINF2(1), SERPING1(1), VWF(4) 56930433 82 65 81 31 24 8 9 28 13 0 0.771 1.000 1.000 544 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG12(1), ALG14(2), B3GNT7(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), CHPF(1), CHST1(1), CHST11(3), CHST12(1), CHST3(1), CHST4(1), CHSY1(1), EXT1(3), EXT2(3), EXTL1(2), EXTL3(2), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT3(2), GALNT4(2), GALNT8(2), GALNTL5(3), GANAB(1), GCNT1(1), HS3ST3A1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1C1(1), MAN2A1(3), MGAT5(1), MGAT5B(2), NDST1(2), NDST3(2), NDST4(5), OGT(1), RPN1(1), ST3GAL1(2), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(5), XYLT2(1) 69048835 83 64 83 25 30 10 8 20 15 0 0.297 1.000 1.000 545 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(3), AKT2(1), BTK(1), CARD11(2), CD79A(1), CD81(2), GSK3B(1), IKBKB(1), INPP5D(2), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG2(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV1(3), VAV2(2), VAV3(3) 46614202 65 58 63 22 19 9 8 19 10 0 0.409 1.000 1.000 546 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(1), CD14(1), CD1B(2), CD1C(3), CD1E(2), CD34(1), CD37(1), CD38(1), CD8A(1), CD8B(2), CR1(1), CSF1R(2), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(1), FLT3LG(1), GP5(3), GP9(1), HLA-DRA(1), IL11RA(1), IL1A(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL7(1), IL7R(1), ITGA1(1), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(3) 51292985 65 57 65 28 18 8 4 25 10 0 0.780 1.000 1.000 547 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(2), DAXX(1), GRB2(1), IKBKB(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K8(1), MAP3K9(2), MAP4K1(1), MAPK1(1), MAPK12(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), MYC(1), PAK1(1), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KB2(1), SHC1(2), SP1(2), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRAF2(4) 58464321 67 56 67 23 21 8 11 15 12 0 0.550 1.000 1.000 548 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK2(1), CLK3(2), CPSF2(1), CSTF2T(1), CSTF3(1), DDX1(1), DHX15(1), DHX16(1), DHX38(1), DHX8(1), DHX9(1), DICER1(2), METTL3(2), NONO(1), NXF1(1), PHF5A(1), POLR2A(3), PPM1G(2), PRPF3(2), PRPF4(1), PRPF4B(1), PRPF8(3), PTBP1(3), RBM17(1), RBM5(2), RNGTT(1), RNMT(2), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(4), SF3B5(1), SNRPA1(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPG(1), SNRPN(2), SRRM1(1), SUPT5H(1) 65963414 60 51 60 16 14 8 15 11 12 0 0.308 1.000 1.000 549 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(2), ADCY8(5), CACNA1A(10), CACNA1B(1), GNAS(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(3), KCNB1(4), PRKACA(2), PRKX(2), SCNN1B(4), SCNN1G(1), TAS1R2(3), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TRPM5(3) 35763638 55 48 55 23 25 3 5 14 8 0 0.731 1.000 1.000 550 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(7), CTCFL(1), DOT1L(3), EED(1), EHMT2(1), EZH1(1), EZH2(1), HCFC1(1), JMJD4(1), MEN1(2), NSD1(2), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(2), PRDM9(3), PRMT1(1), PRMT5(2), PRMT8(1), RBBP5(2), SETD1A(2), SETD2(4), SETDB1(2), SETDB2(1), SUV420H1(1), SUV420H2(1), WHSC1(1), WHSC1L1(3) 73023770 51 46 51 15 14 6 3 13 15 0 0.548 1.000 1.000 551 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), EHHADH(5), HADH(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(3), LCMT2(1), LNX1(1), MAOA(2), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), PRMT8(1), TDO2(1), TPH1(1), TPH2(2), WARS(1) 38087169 46 44 46 22 8 6 6 14 11 1 0.938 1.000 1.000 552 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(1), BCR(1), BTK(1), DAG1(1), EPHB2(3), GRB2(1), ITPKB(2), MAPK1(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PLCG2(2), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3) 33239256 46 43 44 17 15 8 5 11 7 0 0.590 1.000 1.000 553 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BTK(1), CAD(2), DAXX(1), DEDD2(1), DFFA(1), EGFR(3), EPHB2(3), FAF1(4), IL1A(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K5(1), MAPK1(1), MAPK8IP3(3), MET(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PFN1(1), PFN2(2), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(4) 45258364 51 42 50 17 16 4 6 14 11 0 0.542 1.000 1.000 554 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BMP5(3), BMP6(1), BMP7(3), BMP8B(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G3(1), FBXW11(2), GLI1(4), GLI2(3), GLI3(2), GSK3B(1), HHIP(4), LRP2(2), PRKACA(2), PRKX(2), PTCH1(1), PTCH2(4), SHH(2), STK36(3), SUFU(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1) 38350769 52 41 52 22 19 10 7 9 7 0 0.522 1.000 1.000 555 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(6), B3GALT4(2), CDR1(1), DGKI(5), IL6ST(6), RPL10(1), RPL12(1), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL3L(1), RPL5(2), RPL7(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), RPS9(2), SLC36A2(1), UBB(1), UBC(1) 32815063 44 41 44 28 11 8 2 13 10 0 0.999 1.000 1.000 556 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CCNH(1), CDC25A(1), CDK7(1), CDKN1A(2), CDKN1B(5), CDKN2A(1), CREB3(1), CREB3L3(1), CREB3L4(1), E2F3(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MYC(1), MYT1(1), NACA(1), PCNA(1), POLE(4), RB1(2), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(9) 44195269 51 40 51 20 15 4 7 10 14 1 0.772 1.000 1.000 557 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(4), DDX41(1), DDX47(3), DDX50(3), DDX56(1), DHFR(1), ENTPD7(1), EP400(1), ERCC2(3), ERCC3(1), MOV10L1(1), RAD54B(3), RAD54L(1), RUVBL2(2), SETX(3), SKIV2L2(3), SMARCA2(2), SMARCA5(3), SPR(1) 39612926 46 40 46 17 11 9 9 11 6 0 0.554 1.000 1.000 558 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(1), EGFR(3), ERBB2(3), ERBB4(2), ETS1(1), ETV6(1), FMN2(4), GRB2(1), MAPK1(1), NOTCH1(3), NOTCH2(4), NOTCH3(3), NOTCH4(3), PIWIL1(7), PIWIL2(2), PIWIL3(2), RAF1(1), SOS1(1) 31920891 43 39 43 16 13 6 6 10 8 0 0.659 1.000 1.000 559 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), AKT1(3), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(5), F2(1), GSK3B(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NFATC2(2), NPPA(1), PIK3CA(12), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), RAF1(1), SYT1(1) 31794083 46 39 44 18 16 6 6 15 3 0 0.632 1.000 1.000 560 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), BDKRB2(1), CAV1(1), CHRNA1(1), FLT1(3), FLT4(2), KDR(3), NOS3(2), PDE2A(2), PDE3B(1), PRKAR1A(1), PRKAR1B(2), PRKG1(2), RYR2(14), SYT1(1), TNNI1(1) 25356438 41 39 40 21 19 6 1 8 7 0 0.816 1.000 1.000 561 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTR3(1), AKT1(3), CFL1(1), FLNA(1), FLNC(3), FSCN2(1), FSCN3(3), LIMK1(2), MYH2(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PFN1(1), PFN2(2), ROCK1(5), WASF1(1) 30085994 41 39 39 21 11 7 4 15 4 0 0.927 1.000 1.000 562 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), LIMK1(2), MAP3K1(1), MYLK(4), NCF2(3), PAK1(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLD1(3), RAC1(1), RALBP1(1), TRIO(5), VAV1(3), WASF1(1) 22007397 41 37 40 15 13 5 5 13 5 0 0.700 1.000 1.000 563 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), DAXX(1), GRB2(1), HMGN1(1), MAP2K4(3), MAP3K1(1), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), MYC(1), PLA2G4A(3), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRAF2(4) 22708333 40 36 40 15 14 1 7 14 4 0 0.702 1.000 1.000 564 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH4A1(1), AMD1(1), AOC2(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), DAO(1), GOT1(1), GOT2(1), MAOA(2), NOS1(3), NOS3(2), P4HA1(3), P4HA2(1), P4HA3(2), PYCR1(1) 27749972 37 35 36 20 10 5 4 13 5 0 0.963 1.000 1.000 565 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(4), F12(1), F13B(2), F2(1), F5(4), F7(2), F8(1), FGA(5), FGB(2), LPA(2), PLAT(2), PLAU(2), PLG(1), SERPINB2(1), SERPINF2(1), VWF(4) 22197104 37 34 37 17 11 6 4 11 5 0 0.851 1.000 1.000 566 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), DAG1(1), EPHB2(3), GRB2(1), ITK(1), ITPKB(2), LCP2(1), MAPK1(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PLCG1(1), PTPRC(7), RAF1(1), SOS1(1), VAV1(3), ZAP70(3) 35164135 35 33 35 15 15 5 3 9 3 0 0.807 1.000 1.000 567 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), DAXX(1), DFFA(1), GSN(1), LMNA(2), MAP2K7(3), MAP3K1(1), MAP3K5(1), MDM2(1), NUMA1(2), PAK2(1), PRKDC(7), PTK2(2), RB1(2), RELA(2), RIPK1(1), SPTAN1(1), TNF(1), TRAF1(1), TRAF2(4) 43457103 41 32 41 13 14 10 4 7 5 1 0.398 1.000 1.000 568 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), DAO(1), EPRS(3), GLUD2(2), GOT1(1), GOT2(1), NOS1(3), NOS3(2), P4HA1(3), P4HA2(1), P4HA3(2), PARS2(2), PYCR1(1) 22573197 31 31 31 16 10 6 3 9 3 0 0.876 1.000 1.000 569 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 DAXX(1), EGF(2), EGFR(3), ETS1(1), IKBKB(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K5(1), MAPK1(1), PPP2CA(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RELA(2), RIPK1(1), SP1(2), TNF(1), TRAF2(4) 30628263 34 31 34 16 10 4 5 11 4 0 0.862 1.000 1.000 570 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(1), GRB2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(3), INPP5D(2), JAK1(3), JAK3(1), PIK3CA(12), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(2), TYK2(1) 23244626 36 31 34 13 9 7 4 11 5 0 0.598 1.000 1.000 571 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), CBL(1), CFLAR(1), GRB2(1), IRS1(2), JAK1(3), JAK3(1), MAPK1(1), MYC(1), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2) 22451303 34 30 32 13 9 9 3 11 2 0 0.644 1.000 1.000 572 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), ALDH5A1(1), CAD(2), CPS1(3), EPRS(3), GAD1(2), GAD2(6), GFPT2(2), GLUD2(2), GLUL(1), GNPNAT1(1), GOT1(1), GOT2(1), NADSYN1(1), NAGK(1), PPAT(1), QARS(1) 24905783 30 28 30 16 10 4 3 6 7 0 0.915 1.000 1.000 573 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(2), ACAT1(1), ACOT12(2), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), LDHAL6A(1), LDHC(1), ME1(2), ME3(1), PC(1), PCK2(2), PDHA2(3) 29456254 28 28 28 11 7 4 4 9 4 0 0.620 1.000 1.000 574 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AMDHD1(2), AOC2(1), ASPA(1), CNDP1(2), HAL(1), HDC(1), HEMK1(1), LCMT2(1), MAOA(2), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1), UROC1(3) 24882638 28 27 28 14 6 3 4 8 7 0 0.936 1.000 1.000 575 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), MCM10(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), NACA(1), PCNA(1), POLD1(1), POLD3(1), POLE(4), RFC1(1), RFC3(1), RFC5(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1) 31904727 32 26 32 21 9 5 5 6 7 0 0.977 1.000 1.000 576 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(5), EP300(5), IL7(1), IL7R(1), JAK1(3), JAK3(1), PIK3CA(12), PIK3R1(1), STAT5B(1) 17566558 30 26 29 11 8 5 4 11 2 0 0.709 1.000 1.000 577 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CREBBP(5), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(2), PTPRC(7), ZAP70(3) 14485357 25 24 25 13 9 2 3 10 1 0 0.903 1.000 1.000 578 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CREBBP(5), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(2), PTPRC(7), ZAP70(3) 14485357 25 24 25 13 9 2 3 10 1 0 0.903 1.000 1.000 579 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), ACY3(1), AGXT(1), ASPA(1), CAD(2), DARS2(1), DDO(1), GAD1(2), GAD2(6), GOT1(1), GOT2(1), NARS2(1), PC(1), PDHA2(3) 23822084 24 24 24 10 8 4 2 3 7 0 0.721 1.000 1.000 580 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), ALAS2(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), MAOA(2), PISD(1), RDH12(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1), TARS2(2) 26751863 26 24 26 10 8 3 0 7 8 0 0.889 1.000 1.000 581 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), GRB2(1), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), SYT1(1) 25957022 27 23 27 15 10 3 4 9 1 0 0.928 1.000 1.000 582 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), ALDH5A1(1), CAD(2), CPS1(3), EPRS(3), GAD1(2), GAD2(6), GLUL(1), GOT1(1), GOT2(1), NADSYN1(1), PPAT(1), QARS(1) 20939612 24 23 24 14 8 3 3 5 5 0 0.936 1.000 1.000 583 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(5), ACACB(2), ACAT1(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5), LDHAL6A(1), LDHC(1), MUT(1) 25014822 23 23 23 11 7 3 3 8 2 0 0.876 1.000 1.000 584 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA1(1), CA12(1), CA14(2), CA2(2), CA3(1), CA4(1), CA5A(1), CA6(1), CA8(3), CA9(2), CPS1(3), CTH(1), GLUD2(2), GLUL(1), HAL(1) 13389549 24 23 24 10 7 5 1 7 4 0 0.678 1.000 1.000 585 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(1), CAPNS1(1), EGF(2), EGFR(3), ITGA1(1), MAPK1(1), MYLK(4), PRKAR1A(1), PRKAR1B(2), PTK2(2), PXN(2), TLN1(2) 20253332 22 21 22 10 5 2 1 12 2 0 0.843 1.000 1.000 586 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT3(2), GALNT4(2), GALNT8(2), GALNTL5(3), GCNT1(1), OGT(1), ST3GAL1(2), WBSCR17(1) 20345131 23 20 23 12 9 2 1 7 4 0 0.934 1.000 1.000 587 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CREB3(1), DUSP1(1), EEF2K(4), EIF4E(1), MAP2K4(3), MAP3K10(4), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPK12(1), MAPKAPK5(1) 20926495 24 20 23 10 9 3 2 5 5 0 0.782 1.000 1.000 588 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), APOA4(1), APOE(1), CETP(1), CYP7A1(1), DGAT1(1), LDLR(1), LPL(1), LRP1(5), SCARB1(2), SOAT1(1) 17271285 22 20 22 10 7 5 2 4 4 0 0.702 1.000 1.000 589 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(2), C6(4), IL1A(1), IL6(1), ITGA4(2), ITGAL(3), ITGB2(2), SELP(3), SELPLG(1), TNF(1), VCAM1(1) 15634663 21 19 21 10 8 3 3 6 1 0 0.722 1.000 1.000 590 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), CDK7(1), ERCC3(1), GTF2E2(1), POLR1A(3), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3B(1), TAF13(1), TAF5(1), TAF6(1) 22068381 19 19 19 17 5 1 3 9 1 0 0.998 1.000 1.000 591 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(1), F2R(1), FGA(5), FGB(2), PLAT(2), PLAU(2), PLG(1), SERPINB2(1) 8446818 18 17 18 10 7 0 2 8 1 0 0.938 1.000 1.000 592 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AMD1(1), AOC2(1), ARG2(1), CPS1(3), MAOA(2), NAGS(1) 18470328 16 16 16 11 4 1 2 6 3 0 0.981 1.000 1.000 593 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E2(1), GTF2H3(1), STON1(1), TAF1(1), TAF13(1), TAF1L(7), TAF2(1), TAF5(1), TAF5L(1), TAF6(1), TAF7L(2) 22698794 18 15 18 10 5 4 4 3 2 0 0.912 1.000 1.000 594 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(1), NCOR2(4), POLR2A(3) 15658840 14 14 14 17 5 2 1 3 3 0 0.999 1.000 1.000 595 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(5), EP300(5), NCOA3(1), PRKAR1A(1), PRKAR1B(2) 13052115 14 13 14 10 6 0 3 4 1 0 0.949 1.000 1.000 596 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 IKBKB(1), MAP2K4(3), MAP3K1(1), RELA(2), RIPK1(1), TANK(1), TNF(1), TRAF2(4) 15100007 14 13 14 7 6 1 3 4 0 0 0.757 1.000 1.000 597 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 HLA-DRA(1), PTPRC(7), ZAP70(3) 5712127 11 11 11 5 5 2 2 2 0 0 0.616 1.000 1.000 598 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(3), ITGB2(2), PTPRC(7) 7112925 12 11 12 7 5 1 2 4 0 0 0.825 1.000 1.000 599 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), GNAS(2), PLCE1(2), PRKAR1A(1), PRKAR1B(2), RAP2B(1) 9298231 10 10 10 7 3 0 0 7 0 0 0.980 1.000 1.000 600 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PRKACA(2), PRKAR1A(1) 4143561 9 9 9 5 2 0 0 7 0 0 0.964 1.000 1.000 601 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(3), TGFB1(1), TGFB2(2), TNF(1), TNFRSF8(2), TNFSF8(1) 8210874 10 9 10 6 4 1 3 2 0 0 0.836 1.000 1.000 602 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2) 6037308 9 8 9 5 2 0 0 7 0 0 0.938 1.000 1.000 603 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(2) 8214859 8 8 8 7 2 1 0 5 0 0 0.989 1.000 1.000 604 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), MPI(1), PGM1(1), PYGL(2), TREH(1) 8426029 8 8 8 5 4 2 1 1 0 0 0.827 1.000 1.000 605 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT1(2), B4GALT2(2), CHST1(1), CHST4(1), ST3GAL1(2) 7856869 9 7 9 5 7 1 0 1 0 0 0.831 1.000 1.000 606 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 IL4(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR3(1) 6677406 7 7 7 5 1 1 3 2 0 0 0.906 1.000 1.000 607 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), GOT2(1), TYR(2) 2956996 4 4 4 3 2 1 0 1 0 0 0.878 1.000 1.000 608 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), EIF4E(1), LDHC(1) 5643118 3 3 3 3 1 1 0 1 0 0 0.930 1.000 1.000 609 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(1) 3439142 2 2 2 3 1 1 0 0 0 0 0.960 1.000 1.000 610 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(2) 2465689 2 2 2 2 0 0 1 1 0 0 0.943 1.000 1.000 611 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 455860 1 1 1 2 1 0 0 0 0 0 0.977 1.000 1.000 612 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 2672374 1 1 1 2 1 0 0 0 0 0 0.958 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 1037992 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 1082786 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 2029642 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 719836 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000