Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.003 0.165 -9999.0 0.0 -0.66 23.0 23.0 IHH -0.038 0.172 -9999.0 0.0 -0.531 53.0 53.0 SHH Np/Cholesterol/GAS1 -0.088 0.164 -9999.0 0.0 -0.299 172.0 172.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.088 0.163 0.297 172.0 -9999.0 0.0 172.0 SMO/beta Arrestin2 0.002 0.116 -9999.0 0.0 -0.512 10.0 10.0 SMO -0.005 0.121 -9999.0 0.0 -0.489 16.0 16.0 AKT1 0.014 0.081 -9999.0 0.0 -0.421 8.0 8.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.002 0.074 -9999.0 0.0 -0.467 12.0 12.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.005 0.12 -9999.0 0.0 -0.482 16.0 16.0 STIL -0.063 0.166 -9999.0 0.0 -0.459 38.0 38.0 DHH N/PTCH2 0.007 0.068 -9999.0 0.0 -0.364 16.0 16.0 DHH N/PTCH1 0.005 0.114 -9999.0 0.0 -0.447 14.0 14.0 PIK3CA 0.01 0.037 -9999.0 0.0 -0.467 3.0 3.0 DHH 0.003 0.072 -9999.0 0.0 -0.499 10.0 10.0 PTHLH -0.003 0.203 -9999.0 0.0 -0.831 23.0 23.0 determination of left/right symmetry -0.005 0.12 -9999.0 0.0 -0.482 16.0 16.0 PIK3R1 0.007 0.052 -9999.0 0.0 -0.467 6.0 6.0 skeletal system development -0.003 0.201 -9999.0 0.0 -0.82 23.0 23.0 IHH N/Hhip -0.049 0.164 -9999.0 0.0 -0.381 92.0 92.0 DHH N/Hhip -0.024 0.117 -9999.0 0.0 -0.334 62.0 62.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.005 0.12 -9999.0 0.0 -0.482 16.0 16.0 pancreas development -0.038 0.149 -9999.0 0.0 -0.473 52.0 52.0 HHAT 0.004 0.067 -9999.0 0.0 -0.467 10.0 10.0 PI3K 0.014 0.049 -9999.0 0.0 -0.361 8.0 8.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.042 0.154 -9999.0 0.0 -0.469 57.0 57.0 somite specification -0.005 0.12 -9999.0 0.0 -0.482 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.059 0.157 -9999.0 0.0 -0.453 30.0 30.0 SHH Np/Cholesterol/PTCH2 -0.063 0.139 -9999.0 0.0 -0.277 142.0 142.0 SHH Np/Cholesterol/Megalin -0.09 0.163 -9999.0 0.0 -0.299 175.0 175.0 SHH -0.086 0.175 -9999.0 0.0 -0.364 138.0 138.0 catabolic process 0.004 0.117 -9999.0 0.0 -0.488 12.0 12.0 SMO/Vitamin D3 -0.049 0.158 -9999.0 0.0 -0.472 27.0 27.0 SHH Np/Cholesterol/Hhip -0.086 0.168 -9999.0 0.0 -0.313 161.0 161.0 LRP2 -0.045 0.16 -9999.0 0.0 -0.488 57.0 57.0 receptor-mediated endocytosis -0.065 0.172 -9999.0 0.0 -0.475 39.0 39.0 SHH Np/Cholesterol/BOC -0.065 0.142 -9999.0 0.0 -0.279 145.0 145.0 SHH Np/Cholesterol/CDO -0.063 0.139 -9999.0 0.0 -0.278 142.0 142.0 mesenchymal cell differentiation 0.085 0.167 0.311 161.0 -9999.0 0.0 161.0 mol:Vitamin D3 -0.056 0.159 -9999.0 0.0 -0.454 30.0 30.0 IHH N/PTCH2 -0.016 0.115 -9999.0 0.0 -0.324 58.0 58.0 CDON 0.006 0.062 -9999.0 0.0 -0.556 6.0 6.0 IHH N/PTCH1 0.005 0.119 -9999.0 0.0 -0.494 12.0 12.0 Megalin/LRPAP1 -0.022 0.116 -9999.0 0.0 -0.342 57.0 57.0 PTCH2 0.007 0.06 -9999.0 0.0 -0.538 6.0 6.0 SHH Np/Cholesterol -0.067 0.134 -9999.0 0.0 -0.279 138.0 138.0 PTCH1 0.004 0.117 -9999.0 0.0 -0.49 12.0 12.0 HHIP -0.038 0.149 -9999.0 0.0 -0.473 52.0 52.0