Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.028 0.015 -9999.0 0.0 -0.21 2.0 2.0 epithelial cell differentiation 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.038 0.055 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.025 0.131 -9999.0 0.0 -0.467 40.0 40.0 EPHA2 -0.037 0.148 -9999.0 0.0 -0.474 51.0 51.0 MYO6 0.001 0.096 -9999.0 0.0 -0.277 51.0 51.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.176 0.197 -9999.0 0.0 -0.398 219.0 219.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.022 0.053 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.058 0.186 -9999.0 0.0 -0.534 65.0 65.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.013 0.069 -9999.0 0.0 -0.397 15.0 15.0 cortical microtubule organization 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.031 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.018 0.051 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.006 0.084 -9999.0 0.0 -0.308 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.03 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.011 0.078 -9999.0 0.0 -0.28 4.0 4.0 CDH1 0.011 0.03 -9999.0 0.0 -0.467 2.0 2.0 EGFR/EGFR/EGF/EGF -0.047 0.094 -9999.0 0.0 -0.413 4.0 4.0 RhoA/GDP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.005 0.101 -9999.0 0.0 -0.458 3.0 3.0 IGF-1R heterotetramer 0.011 0.034 -9999.0 0.0 -0.52 2.0 2.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.034 -9999.0 0.0 -0.52 2.0 2.0 IGF1 -0.045 0.165 -9999.0 0.0 -0.505 56.0 56.0 DIAPH1 0.002 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.018 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.005 0.103 -9999.0 0.0 -0.471 3.0 3.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.02 0.064 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.021 0.06 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.022 0.053 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.037 0.097 -9999.0 0.0 -0.413 18.0 18.0 HGF -0.026 0.136 -9999.0 0.0 -0.495 38.0 38.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.028 0.015 -9999.0 0.0 -0.211 2.0 2.0 actin cable formation 0.05 0.052 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.038 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.031 0.028 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.026 -9999.0 0.0 -0.573 1.0 1.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.031 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.019 0.019 -9999.0 0.0 -0.414 1.0 1.0 mol:GDP 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.062 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.048 0.038 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.026 0.074 -9999.0 0.0 -0.477 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.036 0.146 -9999.0 0.0 -0.467 51.0 51.0 PLEKHA7 0.033 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.005 0.083 -9999.0 0.0 -0.306 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.054 0.013 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.028 0.015 -9999.0 0.0 -0.21 2.0 2.0 regulation of cell-cell adhesion -0.005 0.101 -9999.0 0.0 -0.458 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.028 0.015 -9999.0 0.0 -0.211 2.0 2.0