E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.086 -9999.0 0.0 -0.256 52.0 52.0 KLHL20 0.014 0.043 0.16 3.0 -0.19 1.0 4.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.015 0.062 0.339 6.0 -9999.0 0.0 6.0 ENAH -0.01 0.085 -9999.0 0.0 -0.256 50.0 50.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.018 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.021 -9999.0 0.0 -0.134 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.049 -9999.0 0.0 -0.155 17.0 17.0 RAPGEF1 -0.008 0.079 0.293 4.0 -0.234 33.0 37.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.092 -9999.0 0.0 -0.26 55.0 55.0 CRK -0.008 0.076 -9999.0 0.0 -0.247 41.0 41.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.021 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.028 0.048 -9999.0 0.0 -0.208 18.0 18.0 IQGAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.009 0.084 -9999.0 0.0 -0.256 49.0 49.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.015 -9999.0 0.0 -0.158 1.0 1.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.026 -9999.0 0.0 -0.162 3.0 3.0 PI3K -0.019 0.019 -9999.0 0.0 -0.201 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.023 0.03 -9999.0 0.0 -0.308 4.0 4.0 E-cadherin(dimer)/Ca2+ 0.052 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.008 0.027 0.109 4.0 -0.122 1.0 5.0 PIK3R1 0.022 0.031 -9999.0 0.0 -0.308 4.0 4.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.018 0.069 0.312 11.0 -9999.0 0.0 11.0 actin cytoskeleton organization 0.015 0.043 0.196 11.0 -0.14 1.0 12.0 CDC42/GDP 0.02 0.072 0.286 16.0 -9999.0 0.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.015 0.064 0.174 3.0 -0.308 18.0 21.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.076 0.3 16.0 -9999.0 0.0 16.0 CDC42/GTP/IQGAP1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.021 0.062 0.378 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.037 0.182 11.0 -9999.0 0.0 11.0 NME1 0.03 0.022 0.174 11.0 -9999.0 0.0 11.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.008 0.084 -9999.0 0.0 -0.257 48.0 48.0 regulation of cell-cell adhesion 0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.02 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.021 0.036 0.187 11.0 -9999.0 0.0 11.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.051 -9999.0 0.0 -0.151 15.0 15.0 CCND1 0.016 0.042 0.242 8.0 -0.11 1.0 9.0 VAV2 0.006 0.088 0.327 1.0 -0.55 1.0 2.0 RAP1/GDP 0.026 0.051 0.268 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.008 0.082 -9999.0 0.0 -0.25 48.0 48.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.046 0.183 6.0 -0.15 14.0 20.0 E-cadherin/beta catenin 0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.087 -9999.0 0.0 -0.256 52.0 52.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 Rac1/GTP 0.002 0.045 -9999.0 0.0 -0.295 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.094 -9999.0 0.0 -0.265 55.0 55.0