Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	96.0	677.0	7.0	-0.049	-0.0	1000.0	-1000.0	-0.013	-1000.0
Angiopoietin receptor Tie2-mediated signaling	90.0	8003.0	88.0	-0.29	0.075	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-alpha and p38-beta	89.0	3940.0	44.0	-0.154	0.027	1000.0	-1000.0	-0.009	-1000.0
Glypican 2 network	87.0	349.0	4.0	0.031	0.061	1000.0	-1000.0	0.02	-1000.0
Endothelins	76.0	7347.0	96.0	-0.194	0.028	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	66.0	7545.0	114.0	-0.407	0.213	1000.0	-1000.0	-0.04	-1000.0
IL23-mediated signaling events	58.0	3507.0	60.0	-0.299	0.046	1000.0	-1000.0	-0.074	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	57.0	1967.0	34.0	-0.05	0.03	1000.0	-1000.0	-0.03	-1000.0
Reelin signaling pathway	53.0	3005.0	56.0	-0.095	0.07	1000.0	-1000.0	-0.022	-1000.0
EPHB forward signaling	52.0	4501.0	85.0	-0.075	0.094	1000.0	-1000.0	-0.042	-1000.0
Thromboxane A2 receptor signaling	50.0	5256.0	105.0	-0.116	0.037	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	47.0	3977.0	84.0	-0.099	0.083	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	44.0	3461.0	78.0	-0.116	0.059	1000.0	-1000.0	-0.047	-1000.0
Aurora B signaling	44.0	3011.0	67.0	-0.091	0.116	1000.0	-1000.0	-0.026	-1000.0
LPA receptor mediated events	43.0	4392.0	102.0	-0.057	0.1	1000.0	-1000.0	-0.044	-1000.0
Syndecan-1-mediated signaling events	42.0	1439.0	34.0	-0.019	0.1	1000.0	-1000.0	-0.018	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	42.0	2879.0	68.0	-0.157	0.062	1000.0	-1000.0	-0.054	-1000.0
HIF-1-alpha transcription factor network	40.0	3068.0	76.0	-0.073	0.07	1000.0	-1000.0	-0.045	-1000.0
Ephrin B reverse signaling	40.0	1926.0	48.0	-0.068	0.034	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	40.0	683.0	17.0	-0.081	0.041	1000.0	-1000.0	-0.014	-1000.0
Noncanonical Wnt signaling pathway	39.0	1016.0	26.0	-0.04	0.027	1000.0	-1000.0	-0.026	-1000.0
S1P1 pathway	38.0	1376.0	36.0	-0.192	0.026	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by the Hedgehog family	37.0	1962.0	52.0	-0.041	0.037	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	36.0	4582.0	125.0	-0.073	0.072	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	36.0	2745.0	75.0	-0.164	0.032	1000.0	-1000.0	-0.041	-1000.0
EPO signaling pathway	35.0	1938.0	55.0	-0.019	0.048	1000.0	-1000.0	-0.023	-1000.0
amb2 Integrin signaling	35.0	2876.0	82.0	-0.113	0.1	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	35.0	602.0	17.0	-0.045	0.042	1000.0	-1000.0	-0.002	-1000.0
Calcium signaling in the CD4+ TCR pathway	35.0	1103.0	31.0	-0.088	0.032	1000.0	-1000.0	-0.031	-1000.0
EGFR-dependent Endothelin signaling events	35.0	753.0	21.0	-0.029	0.045	1000.0	-1000.0	-0.028	-1000.0
Nongenotropic Androgen signaling	34.0	1800.0	52.0	-0.117	0.06	1000.0	-1000.0	-0.018	-1000.0
Osteopontin-mediated events	33.0	1278.0	38.0	-0.054	0.051	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	33.0	235.0	7.0	-0.03	0.027	1000.0	-1000.0	-0.0	-1000.0
Signaling events regulated by Ret tyrosine kinase	32.0	2628.0	82.0	-0.03	0.044	1000.0	-1000.0	-0.03	-1000.0
JNK signaling in the CD4+ TCR pathway	31.0	542.0	17.0	-0.119	0.065	1000.0	-1000.0	-0.027	-1000.0
BMP receptor signaling	31.0	2574.0	81.0	-0.079	0.067	1000.0	-1000.0	-0.02	-1000.0
Effects of Botulinum toxin	31.0	815.0	26.0	-0.027	0.05	1000.0	-1000.0	-0.013	-1000.0
S1P4 pathway	31.0	796.0	25.0	-0.045	0.048	1000.0	-1000.0	-0.014	-1000.0
Glypican 1 network	30.0	1455.0	48.0	-0.034	0.063	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	30.0	2818.0	93.0	-0.056	0.073	1000.0	-1000.0	-0.027	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	30.0	3655.0	120.0	-0.073	0.089	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	30.0	1560.0	51.0	-0.095	0.067	1000.0	-1000.0	-0.077	-1000.0
Fc-epsilon receptor I signaling in mast cells	28.0	2737.0	97.0	-0.067	0.04	1000.0	-1000.0	-0.04	-1000.0
IL4-mediated signaling events	27.0	2468.0	91.0	-0.245	0.12	1000.0	-1000.0	-0.109	-1000.0
PLK1 signaling events	27.0	2349.0	85.0	-0.026	0.081	1000.0	-1000.0	-0.032	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	27.0	1446.0	52.0	-0.046	0.068	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	26.0	1672.0	62.0	-0.037	0.043	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	26.0	2294.0	85.0	-0.121	0.034	1000.0	-1000.0	-0.028	-1000.0
IL12-mediated signaling events	25.0	2212.0	87.0	-0.174	0.065	1000.0	-1000.0	-0.049	-1000.0
FAS signaling pathway (CD95)	25.0	1188.0	47.0	-0.22	0.042	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Cones	24.0	922.0	38.0	-0.041	0.042	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	24.0	172.0	7.0	-0.0	0.067	1000.0	-1000.0	-0.009	-1000.0
Rapid glucocorticoid signaling	24.0	493.0	20.0	-0.054	0.033	1000.0	-1000.0	-0.011	-1000.0
ErbB2/ErbB3 signaling events	23.0	1546.0	65.0	-0.08	0.037	1000.0	-1000.0	-0.047	-1000.0
PDGFR-alpha signaling pathway	23.0	1013.0	44.0	-0.134	0.051	1000.0	-1000.0	-0.024	-1000.0
Plasma membrane estrogen receptor signaling	23.0	1989.0	86.0	-0.131	0.055	1000.0	-1000.0	-0.043	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	22.0	1228.0	54.0	-0.095	0.07	1000.0	-1000.0	-0.02	-1000.0
Syndecan-2-mediated signaling events	22.0	1537.0	69.0	-0.008	0.044	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by PTP1B	22.0	1684.0	76.0	-0.139	0.096	1000.0	-1000.0	-0.042	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1401.0	61.0	-0.122	0.073	1000.0	-1000.0	-0.039	-1000.0
Canonical Wnt signaling pathway	22.0	1170.0	51.0	-0.122	0.117	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	22.0	1200.0	54.0	-0.098	0.06	1000.0	-1000.0	-0.036	-1000.0
BARD1 signaling events	21.0	1205.0	57.0	-0.03	0.045	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	21.0	2721.0	125.0	-0.06	0.051	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	21.0	2135.0	99.0	-0.109	0.064	1000.0	-1000.0	-0.042	-1000.0
Visual signal transduction: Rods	21.0	1126.0	52.0	-0.041	0.058	1000.0	-1000.0	-0.019	-1000.0
S1P3 pathway	20.0	843.0	42.0	-0.028	0.04	1000.0	-1000.0	-0.032	-1000.0
Syndecan-4-mediated signaling events	19.0	1330.0	67.0	-0.049	0.098	1000.0	-1000.0	-0.029	-1000.0
IGF1 pathway	19.0	1093.0	57.0	-0.017	0.059	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	18.0	1263.0	69.0	-0.08	0.059	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	18.0	1138.0	62.0	-0.037	0.067	1000.0	-1000.0	-0.023	-1000.0
IL27-mediated signaling events	18.0	946.0	51.0	-0.347	0.077	1000.0	-1000.0	-0.04	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	18.0	1355.0	74.0	-0.142	0.052	1000.0	-1000.0	-0.044	-1000.0
Insulin Pathway	18.0	1348.0	74.0	-0.124	0.076	1000.0	-1000.0	-0.037	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	18.0	601.0	33.0	-0.066	0.061	1000.0	-1000.0	-0.01	-1000.0
Caspase cascade in apoptosis	17.0	1273.0	74.0	-0.038	0.063	1000.0	-1000.0	-0.025	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2341.0	136.0	-0.07	0.152	1000.0	-1000.0	-0.04	-1000.0
a4b1 and a4b7 Integrin signaling	17.0	88.0	5.0	0.015	0.034	1000.0	-1000.0	0.021	-1000.0
Ceramide signaling pathway	17.0	1358.0	76.0	-0.022	0.072	1000.0	-1000.0	-0.024	-1000.0
Coregulation of Androgen receptor activity	16.0	1259.0	76.0	-0.015	0.068	1000.0	-1000.0	-0.022	-1000.0
Nectin adhesion pathway	16.0	1030.0	63.0	-0.037	0.061	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	16.0	798.0	49.0	-0.0	0.038	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	16.0	690.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	16.0	118.0	7.0	-0.013	0.026	1000.0	-1000.0	-0.011	-1000.0
VEGFR1 specific signals	16.0	948.0	56.0	-0.055	0.042	1000.0	-1000.0	-0.029	-1000.0
Cellular roles of Anthrax toxin	15.0	598.0	39.0	-0.023	0.026	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	999.0	65.0	-0.222	0.065	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	15.0	908.0	60.0	-0.061	0.074	1000.0	-1000.0	-0.02	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	15.0	582.0	37.0	-0.02	0.063	1000.0	-1000.0	-0.022	-1000.0
TCGA08_rtk_signaling	15.0	392.0	26.0	-0.013	0.048	1000.0	-1000.0	-0.003	-1000.0
Class I PI3K signaling events	15.0	1103.0	73.0	-0.042	0.063	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	15.0	127.0	8.0	-0.01	0.058	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by PRL	15.0	531.0	34.0	-0.037	0.046	1000.0	-1000.0	-0.034	-1000.0
Regulation of Androgen receptor activity	15.0	1068.0	70.0	-0.078	0.042	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	14.0	406.0	28.0	-0.026	0.052	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	14.0	754.0	53.0	-0.139	0.05	1000.0	-1000.0	-0.028	-1000.0
Retinoic acid receptors-mediated signaling	14.0	842.0	58.0	-0.042	0.049	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	14.0	840.0	58.0	-0.037	0.07	1000.0	-1000.0	-0.027	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	636.0	46.0	-0.056	0.044	1000.0	-1000.0	-0.079	-1000.0
IL2 signaling events mediated by STAT5	13.0	294.0	22.0	-0.014	0.048	1000.0	-1000.0	-0.029	-1000.0
LPA4-mediated signaling events	11.0	134.0	12.0	-0.03	0.021	1000.0	-1000.0	-0.018	-1000.0
IFN-gamma pathway	11.0	797.0	68.0	-0.023	0.073	1000.0	-1000.0	-0.039	-1000.0
PDGFR-beta signaling pathway	11.0	1075.0	97.0	-0.101	0.07	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	10.0	420.0	40.0	-0.068	0.05	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	10.0	904.0	83.0	-0.047	0.049	1000.0	-1000.0	-0.017	-1000.0
Syndecan-3-mediated signaling events	10.0	350.0	35.0	-0.022	0.072	1000.0	-1000.0	-0.014	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	492.0	45.0	-0.0	0.063	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in keratinocytes	10.0	458.0	43.0	-0.016	0.046	1000.0	-1000.0	-0.014	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	324.0	36.0	-0.046	0.048	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	721.0	76.0	-0.019	0.056	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events mediated by Akt	8.0	552.0	68.0	-0.033	0.05	1000.0	-1000.0	-0.02	-1000.0
FoxO family signaling	8.0	536.0	64.0	-0.021	0.06	1000.0	-1000.0	-0.049	-1000.0
p38 MAPK signaling pathway	8.0	369.0	44.0	-0.03	0.069	1000.0	-1000.0	-0.012	-1000.0
Canonical NF-kappaB pathway	7.0	290.0	39.0	-0.004	0.056	1000.0	-1000.0	-0.019	-1000.0
Atypical NF-kappaB pathway	7.0	232.0	31.0	-0.01	0.031	1000.0	-1000.0	-0.021	-1000.0
Regulation of Telomerase	7.0	813.0	102.0	-0.025	0.058	1000.0	-1000.0	-0.038	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	85.0	15.0	-0.017	0.029	1000.0	-1000.0	-0.024	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.028	0.028	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class II	4.0	318.0	75.0	-0.028	0.065	1000.0	-1000.0	-0.023	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	-0.013	0.027	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	4.0	99.0	22.0	-0.007	0.04	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	4.0	219.0	48.0	-0.011	0.049	1000.0	-1000.0	-0.021	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	86.0	23.0	0.008	0.053	1000.0	-1000.0	-0.021	-1000.0
Insulin-mediated glucose transport	3.0	127.0	32.0	-0.013	0.046	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class I	3.0	329.0	104.0	-0.052	0.064	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	2.0	179.0	71.0	-0.046	0.05	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	2.0	127.0	54.0	-0.006	0.048	1000.0	-1000.0	-0.011	-1000.0
Arf6 downstream pathway	1.0	67.0	43.0	-0.053	0.054	1000.0	-1000.0	-0.032	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.011	0.059	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.046	1000.0	-1000.0	0.021	-1000.0
Alternative NF-kappaB pathway	0.0	9.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Total	3194	188001	7203	-8.95888545809	7.56425198932	131000	-131000	-3.64308638906	-131000