Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	106 (87%)	16	0.80353	1	0.73737	1	0.87464	1	NA	NA	0.22461	0.692	0.52664	0.992	0.22949	0.699	0.04433	0.3	0.03002	0.256	0.27672	0.769	NA	NA	NA	NA
CRIPAK	11 (9%)	111	NA	NA	NA	NA	0.64498	1	0.36144	0.881	0.16316	0.601	0.03884	0.284	0.00194	0.0546	0.0021	0.0546	0.00233	0.0559	0.00131	0.0438	0.26593	0.764	0.76004	1
TP53	90 (74%)	32	0.00033	0.014	0.01341	0.172	0.04164	0.29	0.75326	1	0.35755	0.881	0.36914	0.881	0.17942	0.622	0.080769	0.398	0.14607	0.574	0.01499	0.173	0.26506	0.764	0.29609	0.796
MUC4	25 (20%)	97	NA	NA	NA	NA	0.5162	0.983	0.062909	0.342	0.23281	0.703	0.00306	0.0682	9.9999e-06	0.000585	9.9999e-06	0.000585	9.9999e-06	0.000585	9.9999e-06	0.000585	0.48026	0.97	0.51668	0.983
TCF7L2	13 (11%)	109	0.78263	1	0.17316	0.619	0.71119	1	0.75011	1	0.65302	1	0.8868	1	0.93317	1	0.53573	0.999	0.48342	0.97	0.84481	1	0.33767	0.853	0.83316	1
FMN2	14 (11%)	108	0.27961	0.769	0.86289	1	0.03638	0.279	0.50586	0.978	0.77128	1	0.15334	0.593	0.01002	0.134	0.10827	0.483	0.03516	0.279	0.02985	0.256	0.49674	0.973	1	1
SHROOM4	7 (6%)	115	NA	NA	NA	NA	0.47207	0.969	0.55523	1	0.63781	1	0.082819	0.399	0.01476	0.173	0.00239	0.0559	0.01799	0.196	0.00201	0.0546	0.18612	0.628	0.12846	0.527
RPTN	5 (4%)	117	NA	NA	NA	NA	0.74152	1	0.85258	1	0.29939	0.801	0.15456	0.593	0.051439	0.319	0.04649	0.306	0.065749	0.354	0.069299	0.364	1	1	0.41276	0.911
NRAS	11 (9%)	111	1	1	0.88687	1	0.52152	0.988	1	1	0.36355	0.881	0.79942	1	0.55919	1	0.57332	1	0.49216	0.973	0.25407	0.748	0.88306	1	0.057019	0.325
CDH1	12 (10%)	110	NA	NA	NA	NA	0.75901	1	0.3939	0.901	1	1	0.62136	1	0.01363	0.172	0.0052299	0.0979	0.00389	0.0792	0.0092799	0.131	0.47946	0.97	0.68841	1
ARID1A	11 (9%)	111	0.36591	0.881	0.39321	0.901	0.46788	0.965	0.35422	0.881	0.86228	1	0.11043	0.488	0.81517	1	0.82862	1	0.4963	0.973	0.6034	1	0.66955	1	0.16667	0.608
RBM38	8 (7%)	114	NA	NA	NA	NA	1	1	1	1	0.10271	0.462	0.48651	0.97	0.00181	0.0546	0.0094899	0.131	0.00463	0.0903	0.0089499	0.131	0.67073	1	0.35944	0.881
SMAD2	7 (6%)	115	1	1	0.43253	0.933	0.10074	0.458	1	1	0.26898	0.768	0.12453	0.517	1	1	0.92742	1	0.86612	1	0.39083	0.901	NA	NA	NA	NA
VCX2	5 (4%)	117	NA	NA	NA	NA	0.73699	1	0.36109	0.881	0.81773	1	0.21828	0.681	0.0377	0.284	0.12358	0.517	0.04217	0.29	0.0094799	0.131	0.52787	0.992	0.32112	0.835
ERBB2	8 (7%)	114	1	1	1	1	0.38597	0.899	0.20464	0.66	0.42329	0.921	0.7663	1	0.02564	0.25	0.072239	0.367	0.648	1	0.33765	0.853	0.88411	1	0.57953	1
RBM10	5 (4%)	117	1	1	0.7841	1	0.92434	1	NA	NA	1	1	0.94176	1	0.80306	1	0.78895	1	0.64539	1	0.71064	1	NA	NA	NA	NA
PON3	4 (3%)	118	NA	NA	NA	NA	0.13833	0.553	0.81563	1	NA	NA	NA	NA	0.03487	0.279	0.070029	0.364	0.055229	0.323	0.03254	0.268	0.18666	0.628	0.6492	1
HIST2H2AC	3 (2%)	119	NA	NA	NA	NA	0.2119	0.67	0.61641	1	NA	NA	NA	NA	0.03591	0.279	0.055819	0.323	0.0013	0.0438	0.19524	0.635	0.067329	0.358	0.3738	0.888
CTNNB1	19 (16%)	103	0.052429	0.319	0.17723	0.619	0.89798	1	0.75263	1	0.9336	1	0.050929	0.319	0.02468	0.246	0.00025	0.0117	0.01646	0.183	0.00022	0.0114	1	1	0.16272	0.601
KIAA1804	10 (8%)	112	0.51187	0.982	0.81218	1	0.02117	0.215	NA	NA	0.74461	1	0.40169	0.902	0.50871	0.98	0.46093	0.959	0.079769	0.398	0.0054699	0.0985	NA	NA	NA	NA
OXSM	4 (3%)	118	NA	NA	NA	NA	0.90746	1	0.48103	0.97	0.26523	0.764	0.30963	0.819	0.4032	0.902	0.084509	0.399	0.46708	0.965	0.38531	0.899	NA	NA	NA	NA
BCL9	5 (4%)	117	0.62704	1	0.88161	1	0.27791	0.769	NA	NA	0.30393	0.808	0.72176	1	0.61869	1	0.9431	1	0.072119	0.367	0.24532	0.727	NA	NA	NA	NA
KRAS	63 (52%)	59	0.19227	0.635	0.0068399	0.11	0.0060599	0.105	0.02666	0.255	0.93474	1	0.85123	1	0.45722	0.958	0.1582	0.597	0.8646	1	0.052509	0.319	0.68513	1	0.16203	0.601
SLC12A6	6 (5%)	116	NA	NA	NA	NA	0.45002	0.949	0.44944	0.949	1	1	0.55697	1	0.04211	0.29	0.15113	0.589	0.26562	0.764	0.32666	0.84	NA	NA	NA	NA
ZNF354C	5 (4%)	117	NA	NA	NA	NA	0.6807	1	0.29111	0.788	1	1	0.16862	0.608	0.01512	0.173	0.20638	0.662	0.24151	0.72	0.19339	0.635	0.8825	1	0.14544	0.574
GABRP	4 (3%)	118	NA	NA	NA	NA	0.67264	1	1	1	NA	NA	NA	NA	0.34442	0.862	0.27664	0.769	0.18163	0.625	0.82182	1	NA	NA	NA	NA
BRAF	12 (10%)	110	NA	NA	NA	NA	0.85403	1	0.31294	0.823	0.50191	0.978	0.12473	0.517	0.0067399	0.11	0.093499	0.433	0.057799	0.326	0.0091299	0.131	0.90643	1	0.0414	0.29
PIK3CA	37 (30%)	85	0.85645	1	0.98791	1	0.20847	0.664	0.94204	1	0.18407	0.628	0.053709	0.322	9.9999e-06	0.000585	9.9999e-06	0.000585	9.9999e-06	0.000585	9.9999e-06	0.000585	0.11367	0.493	0.2379	0.714
CEP290	6 (5%)	116	NA	NA	NA	NA	0.73613	1	0.03013	0.256	0.44858	0.949	0.58749	1	0.13697	0.553	0.42104	0.921	0.17603	0.619	0.062219	0.342	0.079989	0.398	0.53091	0.994
LIG1	4 (3%)	118	NA	NA	NA	NA	0.81951	1	0.44866	0.949	0.78118	1	0.43004	0.932	0.02784	0.256	0.12297	0.517	0.083469	0.399	0.03261	0.268	NA	NA	NA	NA
PCBP1	4 (3%)	118	NA	NA	NA	NA	0.81629	1	0.6173	1	NA	NA	NA	NA	0.40846	0.906	0.39996	0.902	0.50529	0.978	0.38201	0.899	NA	NA	NA	NA
ATP8B1	5 (4%)	117	0.49504	0.973	1	1	0.79409	1	NA	NA	1	1	0.28087	0.769	0.59077	1	0.096039	0.441	0.88593	1	0.71101	1	NA	NA	NA	NA
FLT1	8 (7%)	114	NA	NA	NA	NA	0.83688	1	0.85032	1	0.40489	0.902	0.32258	0.835	0.02884	0.256	0.22257	0.69	0.158	0.597	0.38371	0.899	0.12139	0.517	0.57804	1
OBSCN	13 (11%)	109	0.28029	0.769	0.6926	1	0.66956	1	0.48618	0.97	0.67417	1	0.33046	0.845	0.084449	0.399	0.02897	0.256	0.050629	0.319	0.13206	0.537	1	1	0.21413	0.673
VANGL1	3 (2%)	119	NA	NA	NA	NA	0.39465	0.901	NA	NA	1	1	1	1	0.055359	0.323	0.23014	0.699	0.051399	0.319	0.19394	0.635	NA	NA	NA	NA
RRP8	5 (4%)	117	NA	NA	NA	NA	0.48718	0.97	1	1	0.00336	0.0715	0.04489	0.3	0.33886	0.853	0.27404	0.769	0.00093999	0.0367	0.03876	0.284	0.36756	0.881	0.421	0.921
AGL	4 (3%)	118	NA	NA	NA	NA	0.44202	0.949	NA	NA	0.6863	1	0.45863	0.958	0.32299	0.835	0.69397	1	0.54935	1	0.82539	1	NA	NA	NA	NA
RLIM	3 (2%)	119	NA	NA	NA	NA	0.17735	0.619	0.01904	0.203	NA	NA	NA	NA	0.0199	0.207	0.01489	0.173	0.16879	0.608	0.19375	0.635	NA	NA	NA	NA
STK32B	4 (3%)	118	NA	NA	NA	NA	1	1	0.29139	0.788	NA	NA	NA	NA	0.11154	0.488	0.40134	0.902	0.061219	0.341	0.090399	0.423	NA	NA	NA	NA