rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(6), ATM(37), BAX(2), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(6), TP53(109) 3403276 167 98 127 17 48 36 6 43 32 2 4.37e-06 <1.00e-15 <1.71e-13 2 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), FAS(2), GZMB(1), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), PARP1(1), PRF1(1), RELA(1), TNF(1), TNFSF10(1), TP53(109), TRAF1(2) 6152577 152 95 112 15 50 30 4 31 37 0 3.81e-07 <1.00e-15 <1.71e-13 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2), TP53(109) 1293032 116 94 78 10 41 17 3 25 30 0 3.70e-06 <1.00e-15 <1.71e-13 4 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(153), CASP3(1), CREB3(1), CREB5(3), DAG1(2), EPHB2(1), FOS(1), GNAQ(1), ITPKB(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3) 4369054 185 110 152 30 10 18 2 46 70 39 0.00127 1.11e-15 1.71e-13 5 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP1(1), SP3(3), TP53(109), WT1(4) 1194152 117 92 79 7 42 18 3 27 27 0 2.12e-08 2.66e-15 2.85e-13 6 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(7), NFKB1(3), RB1(16), RELA(1), TNF(1), TP53(109), USH1C(4), WT1(4) 3076498 151 95 112 25 49 26 3 41 31 1 0.00228 2.78e-15 2.85e-13 7 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(4), ATM(37), BAX(2), CASP3(1), CASP6(1), CASP9(1), PRKCA(3), STAT1(2), TLN1(2), TP53(109) 4715253 162 97 121 17 43 36 5 43 33 2 7.18e-06 3.77e-15 3.04e-13 8 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(37), BRCA1(3), CHEK1(1), CHEK2(3), MAPK8(6), MRE11A(5), NFKB1(3), RAD50(7), RBBP8(1), RELA(1), TP53(109) 5081623 180 99 138 25 50 41 7 50 30 2 0.000419 4.11e-15 3.04e-13 9 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(4), NFKB1(3), RELA(1), TP53(109) 1620736 117 93 79 10 43 18 3 27 26 0 1.33e-05 4.44e-15 3.04e-13 10 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(13), DAXX(4), PAX3(3), PML(1), RARA(1), RB1(16), SIRT1(1), SP100(1), TNF(1), TP53(109) 3084344 150 96 109 21 51 19 5 43 32 0 9.59e-05 5.11e-15 3.15e-13 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(37), CDC25C(1), CDK4(1), CHEK1(1), MYT1(5), RB1(16), TP53(109), YWHAH(2) 3123186 172 98 131 26 48 34 5 50 33 2 0.00189 3.40e-13 1.90e-11 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(4), ATM(37), BAX(2), CDK4(1), PCNA(3), RB1(16), TIMP3(1), TP53(109) 3170811 173 99 130 27 45 33 5 53 35 2 0.00232 4.33e-13 2.22e-11 13 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(2), APC(153), AXIN1(2), BTRC(4), CTNNB1(21), DLL1(4), FZD1(2), GSK3B(1), NOTCH1(1), PSEN1(1) 2934386 191 110 156 34 8 20 1 55 68 39 0.00594 7.91e-13 3.75e-11 14 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(37), ATR(10), CDC25C(1), CHEK1(1), CHEK2(3), TP53(109), YWHAH(2) 2872666 163 98 120 23 44 33 5 46 33 2 0.00506 6.33e-11 2.79e-09 15 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(153), AXIN1(2), BTRC(4), CREBBP(13), CSNK1D(1), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), PPARD(1) 4652324 200 110 163 36 9 21 2 61 68 39 0.00544 1.04e-07 4.28e-06 16 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(3), IL1R1(1), MAP2K4(4), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(6), MAPK9(3), NFATC3(2), PAPPA(6), SHC1(1), TP53(109), ZAK(4) 8338755 174 102 135 25 58 35 5 38 38 0 8.50e-05 2.06e-07 7.95e-06 17 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(37), ATR(10), BRCA1(3), CDC25C(1), CHEK1(1), CHEK2(3), EP300(14), MYT1(5), PRKDC(5), TP53(109), YWHAH(2) 6952227 190 98 151 28 52 38 6 55 37 2 0.000388 3.23e-06 0.000117 18 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(11), IGF1R(5), POLR2A(2), PRKCA(3), RB1(16), TERF1(1), TERT(2), TNKS(1), TP53(109), XRCC5(2) 4788934 152 96 113 28 49 24 3 46 30 0 0.00445 3.48e-06 0.000119 19 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(3), APC(153), ATF2(1), AXIN1(2), BMP10(2), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CHRD(2), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), NPPB(1), RFC1(5), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3) 5846437 214 111 179 37 16 30 0 61 68 39 0.00273 6.69e-06 0.000217 20 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(4), BAX(2), BCL2L11(1), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CHUK(4), DFFA(2), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF1(1), IRF3(2), IRF4(2), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF21(1), TNFSF10(1), TP53(109), TRAF1(2), TRAF3(2) 9335075 178 98 138 23 57 40 4 37 40 0 8.25e-06 9.80e-06 0.000302 21 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 28 AKT2(1), AKT3(1), APC(153), AXIN1(2), AXIN2(3), CER1(2), CTNNB1(21), DACT1(1), DKK1(1), DKK2(3), DKK3(2), DKK4(3), FSTL1(1), GSK3B(1), LRP1(4), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(1), TSHB(1) 6413427 204 111 169 36 11 27 0 60 67 39 0.00584 2.26e-05 0.000661 22 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(153), CDH1(12), CREBBP(13), EP300(14), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(2), TGFB2(4), TGFBR1(3), TGFBR2(2) 4534542 208 109 173 38 11 17 2 63 76 39 0.00717 3.37e-05 0.000943 23 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(153), AXIN1(2), CREBBP(13), CTNNB1(21), EP300(14), FZD1(2), GSK3B(1), LDB1(2), TRRAP(9) 5487282 217 110 179 41 13 24 2 66 73 39 0.00603 0.000633 0.0170 24 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(2), APC(153), CAV3(1), DAG1(2), EPHB2(1), GNAI1(2), GNAQ(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(12) 7367767 192 108 166 38 18 21 0 45 68 40 0.00976 0.00352 0.0904 25 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(4), CDKN2A(2), PIK3CA(56), PIK3R1(9), POLR1A(3), POLR1B(3), RB1(16), TP53(109) 3319067 202 101 154 37 52 36 4 76 32 2 0.00392 0.00789 0.194 26 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(37), ATR(10), BRCA1(3), BRCA2(22), CHEK1(1), CHEK2(3), FANCA(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(5), RAD17(2), RAD50(7), TP53(109) 7786683 213 99 168 31 49 54 7 63 38 2 0.000625 0.0270 0.639 27 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(9), NRG2(2), NRG3(4), PRKCA(3), PSEN1(1) 1586122 21 16 21 3 6 7 2 3 3 0 0.115 0.0302 0.689 28 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 APC(153), AXIN1(2), CTNNB1(21), FZD1(2), GJA1(4), GNAI1(2), GSK3B(1), LBP(1), MYD88(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RELA(1), TLR4(3) 4812250 259 113 215 54 17 37 1 96 67 41 0.0170 0.0617 1.000 29 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(4) 129236 4 3 4 0 3 1 0 0 0 0 0.274 0.0665 1.000 30 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(2), APAF1(4), CASP3(1), CASP9(1), DAXX(4), FAS(2), HSPB2(1), MAPKAPK2(1), TNF(1) 1838947 17 14 16 1 1 3 0 11 2 0 0.119 0.0668 1.000 31 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1) 1477777 14 13 13 3 3 5 0 2 4 0 0.453 0.0869 1.000 32 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1) 1477777 14 13 13 3 3 5 0 2 4 0 0.453 0.0869 1.000 33 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(4), GNGT1(1), PRKACA(1), PRKAR1A(5) 974544 16 14 16 3 5 4 2 3 2 0 0.245 0.0915 1.000 34 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1) 660538 9 7 9 1 5 2 0 0 2 0 0.253 0.102 1.000 35 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), COPS5(1), EP300(14), HIF1A(2), LDHA(4), NOS3(2), VHL(22) 2764303 49 31 49 9 10 11 0 21 7 0 0.111 0.110 1.000 36 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1), SUCLA2(3) 352237 4 4 4 1 0 3 0 1 0 0 0.665 0.157 1.000 37 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), SNAP25(1), STX1A(1) 555266 5 5 5 1 0 3 0 2 0 0 0.569 0.161 1.000 38 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(4), GNGT1(1), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 2508498 30 21 30 6 14 6 2 6 2 0 0.126 0.162 1.000 39 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1) 435215 5 4 6 2 2 0 0 1 2 0 0.875 0.165 1.000 40 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(1), GRIA2(6) 560749 7 6 7 2 2 3 0 2 0 0 0.491 0.175 1.000 41 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(1) 395820 3 3 3 1 1 0 0 2 0 0 0.695 0.191 1.000 42 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(8), CASP3(1), CASP8(1), CASP9(1), GZMB(1), PRF1(1) 2208499 17 14 13 2 0 2 1 9 5 0 0.306 0.193 1.000 43 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(4), GNGT1(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3) 1549522 18 14 18 3 7 4 2 3 2 0 0.161 0.209 1.000 44 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3G(1) 211832 2 2 2 0 0 0 0 1 1 0 0.788 0.222 1.000 45 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(3), ADORA3(1), LTB4R(1), P2RY1(3), P2RY2(2), P2RY6(1) 865591 15 9 15 2 7 6 0 2 0 0 0.0579 0.223 1.000 46 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 2162414 16 13 16 3 8 3 0 2 3 0 0.197 0.263 1.000 47 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPX1(1), PRKCE(2) 1274748 19 9 20 2 6 8 1 3 1 0 0.0471 0.266 1.000 48 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(1), GAD1(2), HDC(6), TPH1(2) 871833 11 8 11 2 3 6 0 1 1 0 0.286 0.283 1.000 49 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(3), MAP2K1(2), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(3) 1238125 12 8 12 3 6 1 0 4 1 0 0.406 0.289 1.000 50 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3D(1), CD3G(1), GZMB(1), HLA-A(3), ITGAL(3), ITGB2(2), PRF1(1) 1350876 14 10 14 4 2 2 1 4 4 1 0.549 0.293 1.000 51 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPHN(2) 2093736 21 11 22 1 7 9 0 4 1 0 0.0165 0.298 1.000 52 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9) 3670052 49 26 48 9 15 11 4 11 8 0 0.0645 0.339 1.000 53 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9) 3670052 49 26 48 9 15 11 4 11 8 0 0.0645 0.339 1.000 54 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAX(2), BCL2L11(1), CASP8AP2(3), CASP9(1), CES1(1) 1677948 12 13 15 2 1 6 0 2 3 0 0.533 0.357 1.000 55 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(5) 1112829 11 8 11 2 4 5 0 2 0 0 0.408 0.384 1.000 56 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK2(1), HK3(5), IMPA2(1), PGM1(2), PGM3(2), TGDS(1) 1884988 15 13 15 2 10 3 0 1 1 0 0.0784 0.411 1.000 57 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK2(1), HK3(5), PGM1(2), PGM3(2), TGDS(1) 1721912 14 12 14 2 9 3 0 1 1 0 0.109 0.420 1.000 58 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), WASL(2) 2348367 80 45 71 20 8 17 2 45 6 2 0.365 0.437 1.000 59 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS1(1) 522952 3 3 3 1 1 2 0 0 0 0 0.706 0.454 1.000 60 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(13), DFFA(2), GZMA(3), GZMB(1), PRF1(1) 1745786 22 13 20 5 5 4 3 7 3 0 0.301 0.458 1.000 61 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2) 870462 10 6 11 4 5 2 0 1 2 0 0.791 0.464 1.000 62 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), DLL1(4), FURIN(3), NOTCH1(1), PSEN1(1) 1033414 11 8 11 3 5 0 1 1 4 0 0.449 0.466 1.000 63 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2), SHMT1(1) 576879 3 3 3 1 0 1 0 0 2 0 0.909 0.466 1.000 64 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), DFFA(2) 2329837 21 11 19 1 3 9 0 3 6 0 0.0654 0.483 1.000 65 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1), HLA-DRB1(1) 334065 3 2 4 0 2 0 0 0 1 0 0.466 0.493 1.000 66 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 FOS(1), GRB2(2), IL2(1), IL2RA(3), IL2RB(1), IL2RG(1), JAK1(2), JAK3(4), LCK(1), MAP2K1(2), MAPK3(1), MAPK8(6), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3) 3921740 40 21 40 5 8 11 1 12 7 1 0.0452 0.519 1.000 67 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(4), ACTN2(4), BCAR1(1), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), VCL(1) 3009756 40 33 38 9 9 13 0 17 1 0 0.265 0.521 1.000 68 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(3), ITGB1(1), KLRC3(1), KLRC4(1), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(56), PIK3R1(9), SYK(3), VAV1(2) 3181354 83 48 74 19 7 18 1 47 7 3 0.351 0.527 1.000 69 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(3), DNMT1(8), MTNR1A(1), MTNR1B(4), PTGDR(2), PTGFR(1) 1710085 19 15 19 4 12 4 1 2 0 0 0.118 0.529 1.000 70 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), GNAS(4), PLCE1(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAP2B(1) 2354815 22 15 22 4 8 6 2 4 2 0 0.146 0.548 1.000 71 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1) 2660046 17 12 17 2 3 7 0 7 0 0 0.130 0.550 1.000 72 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1) 2660046 17 12 17 2 3 7 0 7 0 0 0.130 0.550 1.000 73 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1) 2660046 17 12 17 2 3 7 0 7 0 0 0.130 0.550 1.000 74 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 268868 3 2 3 1 0 2 0 1 0 0 0.844 0.575 1.000 75 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(3) 362688 4 2 4 0 1 1 0 2 0 0 0.382 0.576 1.000 76 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), IL2RA(3) 2098879 19 11 20 2 6 6 0 4 3 0 0.0588 0.584 1.000 77 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(1), CTH(1), GOT1(1), LDHA(4), LDHB(3) 1142110 10 6 10 2 2 4 0 3 1 0 0.438 0.584 1.000 78 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(8), ARHGEF1(2), GNA12(1), GNAQ(1), GNGT1(1), MYLK(4), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8) 3595863 34 21 31 6 8 9 0 10 7 0 0.160 0.585 1.000 79 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), CFTR(5), GNAS(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 2091976 24 15 24 5 8 7 2 4 3 0 0.183 0.592 1.000 80 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1) 623305 7 3 8 0 2 3 0 1 1 0 0.161 0.597 1.000 81 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1) 2774784 17 12 17 2 3 7 0 7 0 0 0.129 0.606 1.000 82 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), GSS(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1), TXNDC12(2) 3456004 27 20 27 5 5 9 1 9 3 0 0.214 0.607 1.000 83 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), CD3G(1), IL2(1), IL2RA(3), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3), TOB1(2) 1854560 21 10 21 3 4 6 0 7 4 0 0.152 0.612 1.000 84 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(3), F2(1), FGA(4), FGB(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2) 2387283 20 9 19 0 10 5 0 3 2 0 0.00169 0.620 1.000 85 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(14), ESR1(1), MAPK3(1) 2464988 29 18 27 7 6 5 2 9 7 0 0.354 0.624 1.000 86 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(14), NCOA1(2), NCOA2(2) 2975876 31 19 31 6 10 4 2 9 6 0 0.149 0.630 1.000 87 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), RB1(16), SP1(1), SP3(3) 1195984 22 19 21 9 5 3 0 10 4 0 0.823 0.640 1.000 88 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(1), MMP2(6), MMP9(5), RECK(2), TIMP1(1), TIMP3(1) 1278668 16 10 16 3 8 3 0 3 2 0 0.169 0.652 1.000 89 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1) 2758978 27 15 26 5 5 10 0 10 2 0 0.239 0.657 1.000 90 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(1), SDHA(2) 1113200 6 5 6 1 1 1 0 4 0 0 0.476 0.658 1.000 91 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(1), ALOX15(1), DPEP1(1), GGT1(2), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2) 2421565 12 12 12 2 6 1 0 0 5 0 0.389 0.659 1.000 92 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(1), PON1(1), PON2(1), PON3(4), RDH11(1), RDH12(1) 1430039 9 8 7 3 3 2 0 3 1 0 0.653 0.661 1.000 93 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD3G(1) 592941 3 3 3 0 1 0 0 1 1 0 0.559 0.665 1.000 94 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3G(1), FYN(2), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(9) 1485531 16 8 17 2 3 7 0 2 4 0 0.214 0.666 1.000 95 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), FUT1(3), FUT2(1), FUT9(1), GCNT2(2) 952062 9 6 9 3 4 2 0 0 3 0 0.617 0.667 1.000 96 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(4), CRY1(4), PER1(1) 1413270 12 7 12 3 1 4 0 3 3 1 0.571 0.685 1.000 97 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(6), GLI3(7), GSK3B(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), SMO(2) 2589451 29 21 29 9 6 9 0 9 5 0 0.525 0.688 1.000 98 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), PRF1(1), SCAP(3), SREBF2(1) 2931837 24 14 22 3 3 9 1 5 6 0 0.126 0.690 1.000 99 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), IL6(2), LDLR(2) 915304 5 4 5 1 4 0 0 1 0 0 0.364 0.696 1.000 100 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 296271 3 2 3 0 0 2 0 1 0 0 0.434 0.703 1.000 101 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), CYB5R3(1), GCK(3), GFPT1(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), PGM3(2) 2908884 20 13 20 2 9 5 0 4 2 0 0.0514 0.707 1.000 102 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2) 1772911 10 8 10 2 4 2 0 2 2 0 0.432 0.710 1.000 103 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BIRC3(7), CASP8(1), TNF(1) 1295256 9 6 8 2 2 4 0 1 2 0 0.447 0.719 1.000 104 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(5), CAP1(1), CDC25C(1), GNAI1(2), GNAS(4), GNGT1(1), MAPK3(1), MYT1(5), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 3282282 32 20 32 8 11 9 2 7 3 0 0.244 0.743 1.000 105 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT5(2), FUT1(3), FUT2(1), FUT3(2) 1160693 10 7 10 3 5 2 0 1 2 0 0.673 0.744 1.000 106 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 261192 1 1 1 0 0 0 0 1 0 0 0.767 0.745 1.000 107 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(2), YWHAH(2) 1078865 10 9 12 3 0 5 0 2 3 0 0.614 0.753 1.000 108 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(2), APOBEC4(2) 1276694 9 6 9 2 3 3 0 1 2 0 0.445 0.754 1.000 109 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(37), ATR(10), CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), GSK3B(1), RB1(16), TGFB2(4), TP53(109) 5177173 188 100 146 37 50 36 5 56 39 2 0.0136 0.757 1.000 110 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(1) 642691 3 3 4 0 0 1 0 1 1 0 0.483 0.768 1.000 111 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT2(5), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(5) 2444696 19 13 19 3 9 5 0 5 0 0 0.136 0.776 1.000 112 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GSS(1), GSTA2(1), GSTA3(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1) 3090172 22 17 22 5 4 7 1 7 3 0 0.385 0.778 1.000 113 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(2) 2049382 17 10 17 4 2 6 0 4 5 0 0.552 0.780 1.000 114 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), CSF1(1), CSF3(1), IL2(1), IL6(2), IL7(1), IL8(1), IL9(1) 1066240 9 5 9 3 5 4 0 0 0 0 0.545 0.784 1.000 115 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(1), FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), RAF1(3), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1) 4587570 105 51 96 24 13 27 2 55 5 3 0.198 0.786 1.000 116 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(3), SNCAIP(2), UBE2E2(1) 1110643 9 7 9 4 3 5 0 1 0 0 0.774 0.786 1.000 117 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA7(1), PSMB3(1), PSMB8(3) 1474750 7 5 7 0 0 6 1 0 0 0 0.172 0.791 1.000 118 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(1), RAB5A(1), RAB9A(1) 716188 5 3 5 1 1 1 0 2 1 0 0.578 0.795 1.000 119 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), PIK3CA(56), PIK3R1(9), RAF1(3), SHC1(1), SOS1(5), YWHAH(2) 3114678 90 50 81 24 9 20 1 52 6 2 0.450 0.807 1.000 120 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD3G(1), CD58(1), CD8A(1), CSF3(1), IL6(2), IL8(1) 1119323 8 5 8 2 4 1 0 2 1 0 0.534 0.809 1.000 121 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB4(5), ABCC1(5), ABCC3(1) 2376859 17 10 17 4 5 6 1 4 1 0 0.282 0.816 1.000 122 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2) 6018964 116 57 107 25 17 31 3 55 7 3 0.109 0.818 1.000 123 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOC(2) 631920 3 2 3 0 2 0 0 1 0 0 0.415 0.828 1.000 124 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 FOS(1), GRB2(2), INSR(1), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SLC2A4(1), SOS1(5) 4224129 106 52 97 26 13 25 2 57 7 2 0.245 0.831 1.000 125 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(8), GOT1(1) 1348548 11 6 11 3 3 3 0 2 3 0 0.584 0.835 1.000 126 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(1), CTH(1), MUT(1) 803468 4 3 4 2 1 2 0 0 1 0 0.880 0.837 1.000 127 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACA(6), ACACB(3), OXSM(4) 2159914 13 11 12 3 3 2 0 5 3 0 0.492 0.840 1.000 128 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), GNAQ(1), ITPKB(1) 914798 4 3 4 1 0 1 0 2 1 0 0.644 0.846 1.000 129 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), SQLE(1) 493950 2 2 3 0 0 2 0 0 0 0 0.588 0.849 1.000 130 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(1), MPO(4), PRDX6(1), TPO(7) 1334550 14 11 14 4 6 5 1 1 1 0 0.492 0.849 1.000 131 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25C(1), CSK(2), GRB2(2), PRKCA(3), PTPRA(1) 1584281 9 7 9 2 3 5 0 1 0 0 0.435 0.856 1.000 132 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 IL8(1) 262118 1 1 1 0 0 1 0 0 0 0 0.769 0.857 1.000 133 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(2), KERA(2), LUM(2) 621410 7 5 7 3 3 1 0 3 0 0 0.781 0.859 1.000 134 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), LMNA(1), LMNB1(2), LMNB2(1), PRF1(1) 3280927 28 13 26 4 6 10 1 4 7 0 0.159 0.864 1.000 135 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), UGDH(1) 1382946 9 5 9 2 1 3 1 2 2 0 0.466 0.864 1.000 136 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(14), CREB3(1), CREB5(3), RAF1(3), SNX13(1), TERF2IP(1) 1904127 24 18 24 7 4 5 2 12 1 0 0.565 0.864 1.000 137 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(2), UXS1(1) 831311 5 3 6 0 0 2 0 2 1 0 0.300 0.867 1.000 138 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), SHC1(1), SOS1(5) 1484162 8 7 8 2 0 3 0 5 0 0 0.610 0.868 1.000 139 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2), SHMT1(1) 828352 3 3 3 2 0 1 0 0 2 0 0.978 0.868 1.000 140 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1) 2095465 10 7 10 1 4 4 0 2 0 0 0.189 0.879 1.000 141 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(2), C5(5), C6(3), C7(1), C8A(3), C9(1) 2144658 15 9 17 3 5 6 0 2 2 0 0.324 0.881 1.000 142 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(1), CDC42(1), CHUK(4), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RAF1(3), RALA(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1) 3166884 87 50 78 23 12 16 2 50 5 2 0.408 0.886 1.000 143 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 55 APC(153), AXIN1(2), CTNNB1(21), DVL2(1), DVL3(2), FBXW2(1), FZD1(2), FZD10(2), FZD3(3), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LDLR(2), MAPK10(4), MAPK9(3), PLAU(1), PPP2R5C(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RHOA(1), SFRP4(4), TCF7(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1) 9049837 243 111 207 55 22 42 1 64 75 39 0.0372 0.888 1.000 144 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(2), GAD1(2), GGT1(2) 950667 6 5 6 3 2 2 0 0 2 0 0.905 0.888 1.000 145 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(7), JAK3(4), MAPK3(1) 1951625 14 12 14 7 0 3 0 6 3 2 0.974 0.893 1.000 146 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), METTL2B(1), METTL6(3), PCYT1A(1), PCYT1B(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3) 2285670 14 10 14 4 5 4 0 3 2 0 0.455 0.898 1.000 147 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2) 1438828 10 6 10 7 2 1 0 2 5 0 0.966 0.901 1.000 148 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), ACADS(1), ECHS1(1), HADHA(2) 915561 9 6 9 4 3 2 0 0 4 0 0.842 0.904 1.000 149 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(2) 471862 3 1 3 2 0 2 0 0 1 0 0.892 0.906 1.000 150 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(1), CFLAR(1) 648979 3 2 3 0 0 1 0 1 1 0 0.632 0.907 1.000 151 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(13), EP300(14), NCOA3(7), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RARA(1) 3505195 45 24 43 10 11 11 2 12 9 0 0.215 0.911 1.000 152 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MAPK8(6), PLCG1(2), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1) 3652147 33 20 33 8 7 7 1 16 1 1 0.421 0.913 1.000 153 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(5) 5565557 46 24 45 9 13 17 0 14 2 0 0.122 0.914 1.000 154 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(3), FSHB(2), FSHR(3), GNAS(4), XPO1(2) 1531736 19 17 19 6 6 2 3 6 2 0 0.592 0.916 1.000 155 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ESR1(1), GREB1(5), HSPB2(1), MTA3(1), TUBA8(1) 1533189 9 7 10 2 3 3 0 2 1 0 0.430 0.916 1.000 156 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), NAGS(1), OAT(1), ODC1(3), OTC(3) 2950251 26 12 26 6 10 6 1 5 4 0 0.261 0.921 1.000 157 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(9), IL6(2), IL9(1), TGFB2(4) 1441978 17 11 16 6 3 8 0 4 2 0 0.640 0.922 1.000 158 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(153), AR(6), BRAF(14), DAG1(2), EGFR(11), GNA15(1), GNAI1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), MAPK10(4), MAPK14(1), PHKA2(4), PIK3CA(56), PIK3CD(1), PIK3R1(9), RAF1(3) 8633690 286 113 248 65 23 36 2 108 75 42 0.0607 0.922 1.000 159 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2) 950094 7 3 7 2 4 1 1 0 1 0 0.481 0.922 1.000 160 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2) 950094 7 3 7 2 4 1 1 0 1 0 0.481 0.922 1.000 161 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(2), B4GALT5(1), FUT8(1), ST3GAL1(1) 1308066 6 6 6 2 3 1 0 1 1 0 0.687 0.924 1.000 162 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), ESRRA(9), HDAC5(1), MEF2A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SLC2A4(1), YWHAH(2) 3352393 28 19 23 8 7 7 0 4 10 0 0.680 0.926 1.000 163 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), GGPS1(1), SQLE(1) 689259 3 2 4 1 0 3 0 0 0 0 0.749 0.927 1.000 164 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 FOS(1), GRB2(2), MAP2K1(2), MAPK3(1), MAPK8(6), NGFR(1), PIK3CA(56), PIK3R1(9), PLCG1(2), RAF1(3), SHC1(1), SOS1(5) 3186573 89 48 80 22 10 20 2 51 4 2 0.337 0.928 1.000 165 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(3), WASL(2) 1405901 11 4 11 1 4 2 0 3 2 0 0.143 0.930 1.000 166 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), HSD3B1(1), HSD3B2(1) 1146613 6 6 6 3 1 3 0 1 1 0 0.835 0.932 1.000 167 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 BAX(2), BFAR(1), BTK(1), CAD(3), CASP3(1), CASP8(1), CASP8AP2(3), CD7(2), DAXX(4), DEDD(1), DFFA(2), EGFR(11), EPHB2(1), IL8(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(8), SMPD1(1), TP53(109), TPX2(1) 11299725 197 99 172 34 58 44 5 53 37 0 0.000757 0.934 1.000 168 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(2), MUSK(2), PIK3CA(56), PIK3R1(9), TERT(2), YWHAH(2) 2593821 73 44 65 21 8 16 1 41 5 2 0.646 0.935 1.000 169 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(8) 1301269 10 4 10 4 1 4 0 5 0 0 0.783 0.936 1.000 170 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(2) 690278 2 2 2 0 0 2 0 0 0 0 0.625 0.940 1.000 171 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(14), CREB3(1), CREB5(3), DUSP6(1), EEF2K(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TRAF3(2) 5061440 52 28 49 12 8 17 2 21 4 0 0.243 0.942 1.000 172 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CD3G(1), CXCR3(1), ETV5(2), IL12A(1), IL12RB2(5), IL18R1(3), JAK2(7), MAP2K6(1), MAPK14(1), MAPK8(6), STAT4(3) 3194622 32 19 32 9 3 9 1 15 3 1 0.667 0.942 1.000 173 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(2), PSMD2(1), PSMD6(3) 2859624 16 7 15 1 5 7 0 3 1 0 0.0620 0.944 1.000 174 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 NR3C1(3), TNF(1) 931316 4 4 3 2 0 0 0 3 1 0 0.854 0.944 1.000 175 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), AKT3(1), GRB2(2), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(56), PIK3CD(1), SHC1(1), SOS1(5) 2563797 72 40 63 20 5 19 1 46 1 0 0.574 0.944 1.000 176 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(37), CDC25C(1), CHEK1(1), MYT1(5), YWHAH(2) 2419065 46 30 44 12 5 16 2 17 4 2 0.489 0.948 1.000 177 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), NOS1(8), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3) 4173987 41 22 41 10 18 13 0 6 3 1 0.104 0.948 1.000 178 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GCK(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PMM1(2), SORD(2) 4045688 31 18 31 6 13 10 1 6 1 0 0.0849 0.949 1.000 179 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TAL1(1), TKT(1) 3278698 20 15 20 4 8 7 0 4 1 0 0.172 0.950 1.000 180 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(14), CPEB1(3), EGFR(11), ERBB2(9), ERBB4(9), ETS1(4), ETS2(1), ETV6(1), FMN2(16), GRB2(2), KRAS(63), MAP2K1(2), MAPK3(1), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PIWIL1(4), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(3), SOS1(5), SOS2(2), SPIRE1(2), SPIRE2(2) 8263032 179 92 118 35 20 89 2 43 25 0 0.0333 0.951 1.000 181 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1) 1353865 7 4 7 3 1 2 1 2 1 0 0.790 0.951 1.000 182 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1) 1353865 7 4 7 3 1 2 1 2 1 0 0.790 0.951 1.000 183 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1) 950968 7 6 6 4 0 2 0 3 2 0 0.907 0.952 1.000 184 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2) 1753794 11 8 11 4 8 1 1 0 1 0 0.490 0.954 1.000 185 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), ST3GAL6(4) 2281431 22 13 22 5 8 4 1 5 4 0 0.325 0.955 1.000 186 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(1), CTH(1), GOT1(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), SULT1B1(1) 2143492 13 6 13 4 2 5 0 5 1 0 0.639 0.955 1.000 187 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ANKRD1(2), IFRD1(5), IL1R1(1), MYOG(1), NR4A3(2) 1772508 11 5 11 1 4 4 0 2 1 0 0.139 0.955 1.000 188 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), DFFA(2), GZMB(1), TOP2A(1), TOP2B(1) 1339637 6 5 13 2 0 3 0 2 1 0 0.767 0.956 1.000 189 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(2), JAK1(2), STAT1(2), STAT5A(2), TNF(1) 2077874 13 9 13 4 5 3 0 2 2 1 0.574 0.958 1.000 190 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(5), ABCG2(5), BCHE(4), CES1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1) 4085275 26 15 26 5 6 12 1 5 2 0 0.120 0.960 1.000 191 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 FOS(1), GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SOS1(5) 4101291 109 54 100 29 13 26 2 60 6 2 0.355 0.961 1.000 192 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK3(1), MAPK8IP3(1), PAPPA(6), RPS6KA3(3), SHC1(1), SOS1(5), SYK(3), VAV1(2), VAV2(2), VAV3(3) 5192774 38 19 38 7 8 18 0 8 4 0 0.125 0.961 1.000 193 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(2), HADHA(2) 838193 5 5 4 4 0 1 0 2 2 0 0.982 0.961 1.000 194 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(1), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(2), PTPRC(9) 2313659 21 9 25 6 3 9 0 4 5 0 0.510 0.961 1.000 195 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE3A(6) 1741854 11 4 11 2 3 5 0 2 1 0 0.343 0.962 1.000 196 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(1), ADCY9(3), AK1(1), ARF4(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(2), PLCG2(5), PRKCA(3), SEC61A1(1), TRIM23(5) 6247478 47 29 47 10 18 11 2 13 3 0 0.0910 0.962 1.000 197 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), TPO(7), TYR(3) 1534444 18 14 18 5 7 5 2 2 2 0 0.435 0.963 1.000 198 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 FOS(1), MAPK14(1), MAPK8(6), NFE2L2(3), PRKCA(3) 1386831 14 7 14 3 5 4 1 3 1 0 0.313 0.964 1.000 199 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(2), PRKCA(3) 1149145 7 7 7 3 4 2 0 1 0 0 0.741 0.965 1.000 200 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(1), ALAS2(2), CPO(1), FECH(1), GATA1(1), HBB(1), HMBS(1), UROD(1) 1425802 10 6 10 2 4 4 0 1 1 0 0.377 0.965 1.000 201 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA7(1), PSMB3(1), RPN2(1), UBE2A(1), UBE3A(6) 2276875 12 5 12 1 3 8 0 1 0 0 0.140 0.966 1.000 202 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(2), NTRK1(1), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), SHC1(1), SOS1(5) 2641891 79 47 70 21 8 18 1 47 3 2 0.521 0.966 1.000 203 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3) 1403855 9 7 9 4 3 3 0 1 2 0 0.776 0.967 1.000 204 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(1), JAK1(2), JAK2(7), STAT1(2) 1471216 14 10 14 6 2 3 0 6 1 2 0.901 0.968 1.000 205 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR1H4(2) 866845 4 2 4 1 3 0 0 1 0 0 0.507 0.968 1.000 206 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(2), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), SHC1(1) 2365858 14 9 14 4 2 3 0 4 4 1 0.680 0.968 1.000 207 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(1), HADHA(2), HADHB(1), HSD17B10(1), PPT2(1) 1461136 8 7 8 4 2 3 0 0 3 0 0.882 0.969 1.000 208 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(4), CRY1(4), CSNK1D(1), NR1D1(1), PER1(1), PER2(2), PER3(2) 2824446 18 9 18 4 3 5 0 5 4 1 0.358 0.971 1.000 209 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SCLY(1), SEPHS1(2) 4047222 27 14 27 7 5 9 0 6 7 0 0.451 0.972 1.000 210 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPPL2(1), GGH(1) 863637 2 2 2 1 1 1 0 0 0 0 0.749 0.972 1.000 211 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(1), CHN1(1), LIMK1(1), MAP3K1(3), MYLK(4), NCF2(2), PAK1(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLD1(3), PPP1R12B(5), RALBP1(2), TRIO(2), VAV1(2), WASF1(3) 5979535 103 52 94 24 14 29 2 48 8 2 0.215 0.972 1.000 212 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25C(1), MNAT1(1), XPO1(2) 1503369 4 4 4 2 1 1 0 2 0 0 0.880 0.973 1.000 213 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), ANGPTL2(1), DAG1(2), ETFA(1), ITGA9(4), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(2), PI3(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), RIPK3(1), RPS4X(2), SGCB(4) 7710805 112 56 111 26 18 26 1 52 11 4 0.177 0.974 1.000 214 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1) 1601269 10 8 10 4 5 1 0 2 2 0 0.721 0.974 1.000 215 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR3(2), CCR4(1), CCR7(2), CD28(1), CXCR3(1), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), TGFB2(4) 3493036 26 13 26 5 6 10 0 7 3 0 0.137 0.975 1.000 216 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), CAMK2D(1), GNAS(4), GRB2(2), MAPK14(1), MAPK3(1), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RPS6KA5(3), SOS1(5) 4828648 100 53 91 25 17 22 3 50 6 2 0.321 0.976 1.000 217 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(13), EP300(14), FYN(2), IL2RG(1), IL7(1), IL7R(1), JAK1(2), JAK3(4), LCK(1), NMI(1), PIK3CA(56), PIK3R1(9), STAT5A(2), STAT5B(1) 4785624 108 50 97 28 14 26 3 50 12 3 0.411 0.976 1.000 218 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTR(1) 2950110 28 13 28 8 12 10 1 1 4 0 0.352 0.976 1.000 219 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(5), AASDHPPT(1), AASS(3) 1252249 10 9 10 4 0 4 0 5 1 0 0.843 0.977 1.000 220 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(2) 1320519 10 5 10 3 2 6 0 0 2 0 0.739 0.978 1.000 221 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(3), CBX3(1), CLOCK(4), CRY1(4), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(2), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(2), UGP2(2), ZFR(6) 6189521 48 17 48 8 8 17 0 16 6 1 0.0778 0.979 1.000 222 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), GNAI1(2), GNGT1(1), ITGAV(4), ITGB3(4), MAPK3(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLCB1(1), PRKCA(3), SMPD1(1), SPHK1(1) 4667032 96 56 87 27 12 24 3 46 9 2 0.495 0.979 1.000 223 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD5(2), CD7(2), IFNA1(1), IL10(1), IL12A(1), ITGAX(2), TLR2(5), TLR4(3), TLR7(3), TLR9(4) 3128816 28 10 28 6 9 11 0 5 3 0 0.164 0.980 1.000 224 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3) 2311707 11 7 11 4 4 3 0 2 2 0 0.626 0.980 1.000 225 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), SP1(1), SP3(3) 3331951 22 16 22 6 12 3 0 3 4 0 0.345 0.982 1.000 226 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), AOC3(1), CES1(1), CES7(1), DDHD1(12), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), PLA1A(2), PRDX6(1), SH3GLB1(1) 4327754 46 25 36 11 7 13 0 12 14 0 0.540 0.983 1.000 227 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(37), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F3(1), E2F6(3), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MNAT1(1), MYT1(5), NACA(5), PCNA(3), POLA2(1), POLE(4), POLE2(1), RB1(16), RBL1(3), TFDP2(1), TP53(109) 11596629 214 103 169 40 57 43 6 66 40 2 0.00239 0.984 1.000 228 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA4(1), NDUFS1(2), NDUFS2(3) 1237909 6 4 6 2 3 2 0 0 1 0 0.708 0.984 1.000 229 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(2), MAPK14(1), THBS1(2) 1238686 7 4 7 3 2 3 0 2 0 0 0.783 0.984 1.000 230 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR2(1), JAK1(2), STAT1(2), STAT2(2) 1840346 8 5 8 5 1 3 0 1 2 1 0.938 0.984 1.000 231 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1) 931278 3 3 3 2 1 2 0 0 0 0 0.829 0.985 1.000 232 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), PDE6A(2), PDE6C(2), SLC6A13(1), TF(5) 5670315 29 17 36 5 8 11 0 5 4 1 0.0884 0.985 1.000 233 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2) 2239579 21 16 21 8 8 3 0 6 2 2 0.835 0.987 1.000 234 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD3G(1), CD8A(1), ITGAL(3), ITGB2(2), PTPRC(9) 1804762 18 9 18 6 4 7 0 2 5 0 0.531 0.987 1.000 235 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(3), TGM2(2) 840874 7 4 7 2 4 3 0 0 0 0 0.392 0.988 1.000 236 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2) 1216574 6 2 6 0 0 4 0 2 0 0 0.224 0.988 1.000 237 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPN2(2), EP300(14), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3) 3880987 30 20 30 8 12 7 0 5 6 0 0.310 0.988 1.000 238 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 MAP2K3(3), MAPK14(1), NFATC1(2), NFATC2(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 1748308 18 14 18 9 7 4 1 4 2 0 0.826 0.989 1.000 239 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(1), EGFR(11), RAB5A(1), TF(5), TFRC(2) 2225766 24 16 24 9 6 7 0 9 2 0 0.747 0.989 1.000 240 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), TAT(2), TYR(3) 838749 6 4 6 4 1 2 1 1 1 0 0.923 0.989 1.000 241 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(9), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2), PRKCE(2) 3143960 26 17 24 8 6 7 0 9 4 0 0.707 0.990 1.000 242 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 13 CHST11(2), CHST12(2), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2) 1643331 10 5 10 3 3 4 0 3 0 0 0.571 0.990 1.000 243 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD3G(1), ITGAL(3), ITGB2(2), PTPRC(9) 1921983 17 8 17 6 3 7 0 2 5 0 0.600 0.991 1.000 244 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 2914484 13 8 13 3 2 6 0 3 2 0 0.409 0.991 1.000 245 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7) 1785790 12 9 12 9 1 4 0 5 0 2 0.993 0.991 1.000 246 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7) 1785790 12 9 12 9 1 4 0 5 0 2 0.993 0.991 1.000 247 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 FAU(1), MRPL13(2), RPL10A(1), RPL11(2), RPL19(1), RPL28(1), RPL6(2), RPL7(1), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS6(1) 3388037 19 12 19 4 2 6 1 8 2 0 0.432 0.991 1.000 248 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TKT(1), TKTL1(1), TKTL2(3) 3870101 23 17 23 6 8 8 1 5 1 0 0.280 0.992 1.000 249 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CYP2C19(1), CYP2C9(3), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1) 5212221 44 20 42 11 7 15 1 16 5 0 0.395 0.992 1.000 250 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(1), AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AMD1(1), AOC3(1), ARG2(1), ASL(2), ASS1(1), CPS1(8), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(3), SAT1(1), SAT2(1) 5020824 41 21 40 11 13 12 1 7 8 0 0.277 0.992 1.000 251 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(3), FYN(2), LRP8(4), RELN(12), VLDLR(2) 2430400 24 14 24 9 6 11 1 4 2 0 0.724 0.992 1.000 252 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP5(8), ARHGAP6(1), ARHGEF1(2), ARHGEF11(4), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(4), OPHN1(4), PIP5K1B(1), PPP1R12B(5), ROCK1(8), TLN1(2), VCL(1) 7880187 45 24 42 8 9 11 0 15 10 0 0.114 0.993 1.000 253 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), FOS(1), GNAI1(2), GNAQ(1), GNAS(4), GNGT1(1), MAP2K1(2), MAPK3(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RAF1(3), RPS6KA3(3) 5578735 50 30 50 12 21 10 2 11 6 0 0.134 0.993 1.000 254 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTAP(1), MTR(1), TAT(2) 3468659 32 13 32 9 12 14 1 1 4 0 0.328 0.993 1.000 255 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 137 APC(153), AXIN1(2), AXIN2(3), BTRC(4), CACYBP(1), CAMK2D(1), CER1(2), CHD8(2), CREBBP(13), CSNK1A1L(1), CTBP2(1), CTNNB1(21), CUL1(1), DAAM1(2), DAAM2(5), DKK1(1), DKK2(3), DKK4(3), DVL2(1), DVL3(2), EP300(14), FBXW11(1), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(6), MAPK9(3), MMP7(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRICKLE1(6), PRICKLE2(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PSEN1(1), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(4), SMAD2(7), SMAD3(5), SMAD4(25), TBL1X(1), TCF7(3), TCF7L1(1), TCF7L2(13), TP53(109), VANGL1(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1) 24995909 532 121 451 97 114 106 6 136 131 39 3.29e-07 0.994 1.000 256 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 679251 1 1 1 1 0 1 0 0 0 0 0.952 0.994 1.000 257 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 4588575 23 16 23 5 5 11 0 4 3 0 0.245 0.994 1.000 258 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1) 2844682 25 16 25 8 5 5 0 13 1 1 0.700 0.994 1.000 259 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(2), NR1I3(2), PTGS1(1), PTGS2(1) 921354 7 6 7 4 4 1 0 1 1 0 0.867 0.994 1.000 260 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(4), CLTA(1), CLTB(1), COPA(1), GBF1(2), GPLD1(4), KDELR2(1) 2845724 14 7 14 4 6 3 0 3 2 0 0.502 0.995 1.000 261 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 14 B3GNT2(1), B4GALT1(1), B4GALT3(2), CHST1(1), CHST2(2), CHST4(2), FUT8(1), ST3GAL1(1) 1771665 11 9 11 5 6 1 1 1 2 0 0.785 0.995 1.000 262 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2) 1336344 9 7 8 5 1 3 0 3 2 0 0.933 0.995 1.000 263 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(2), HADHA(2), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1) 2030764 11 8 10 6 1 3 0 3 4 0 0.940 0.995 1.000 264 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRB(1), CP(6), CPOX(1), EPRS(4), FECH(1), HCCS(2), HMBS(1), HMOX2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1) 4644381 27 17 27 5 5 13 0 6 3 0 0.205 0.995 1.000 265 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(2), MBTPS1(3), SCAP(3), SREBF2(1) 1836476 9 4 9 3 3 2 0 3 1 0 0.562 0.995 1.000 266 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CSNK1D(1), DRD2(2), GRM1(5), PLCB1(1), PPP3CA(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2) 2656434 22 15 22 8 10 4 1 4 3 0 0.565 0.995 1.000 267 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(5), ARHGEF1(2), F2(1), GNA12(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(56), PIK3R1(9), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8) 4353911 97 54 88 25 14 23 1 47 10 2 0.393 0.995 1.000 268 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(2), PTPRU(6), REG1A(2), STAT1(2), STAT2(2) 2115965 14 11 14 6 9 2 0 1 1 1 0.749 0.996 1.000 269 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(2), FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1) 1712522 13 8 13 5 7 1 0 3 2 0 0.657 0.996 1.000 270 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1) 4137342 38 22 36 10 6 13 0 14 5 0 0.442 0.996 1.000 271 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(6), ACACB(3), ACADM(3), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), ECHS1(1), EHHADH(2), HADHA(2), HIBCH(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1) 6985794 53 24 52 11 9 18 1 15 10 0 0.174 0.996 1.000 272 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT2(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1) 1463516 9 9 8 7 1 4 0 2 2 0 0.983 0.996 1.000 273 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(4), FOS(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TLR10(3), TLR2(5), TLR3(2), TLR4(3), TLR6(2), TLR7(3), TLR9(4) 6044138 54 21 54 14 14 21 2 13 3 1 0.265 0.996 1.000 274 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3) 1561900 9 9 9 7 1 3 0 4 1 0 0.989 0.996 1.000 275 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(2), JAK2(7), PTPRU(6), REG1A(2), STAT1(2) 1980539 21 16 21 8 10 3 0 6 0 2 0.781 0.996 1.000 276 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPP(1), ENPP3(2), TYR(3) 1697709 7 6 7 5 2 1 1 1 1 1 0.962 0.997 1.000 277 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(4), ACTN2(4), BCAR1(1), BCR(1), CAV1(1), CSK(2), FYN(2), GRB2(2), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MAPK8(6), PPP1R12B(5), RAF1(3), RAP1A(1), ROCK1(8), SHC1(1), SOS1(5), TLN1(2), VCL(1), ZYX(3) 7521569 59 27 59 10 15 19 1 17 7 0 0.0370 0.997 1.000 278 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2) 2193948 16 8 15 6 1 5 1 5 4 0 0.738 0.997 1.000 279 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ITGAL(3), ITGAM(1), ITGB2(2), SELE(2) 1603012 9 7 11 5 2 5 0 0 2 0 0.822 0.997 1.000 280 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C2(1), AKR1C3(2), AKR1C4(2), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(1), CYP3A43(3), CYP3A7(2), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2) 9548730 71 33 67 15 9 22 1 23 16 0 0.157 0.997 1.000 281 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 4 AOX1(3), PSAT1(1) 802966 4 1 4 1 0 3 0 0 1 0 0.791 0.997 1.000 282 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(3) 851050 5 5 5 3 0 1 0 3 1 0 0.925 0.997 1.000 283 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CXCR4(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RELA(1) 4430162 88 52 80 25 14 20 1 45 6 2 0.543 0.997 1.000 284 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELE(2) 2035867 15 8 15 6 1 9 0 2 3 0 0.763 0.997 1.000 285 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1) 1751734 7 5 8 3 3 2 0 2 0 0 0.755 0.997 1.000 286 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), UROD(1) 1346499 8 5 8 2 4 2 0 2 0 0 0.578 0.997 1.000 287 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD3G(1), CXCR3(1), IL12A(1), IL12RB2(5), JAK2(7), STAT4(3) 2543566 19 14 19 6 1 4 0 12 1 1 0.791 0.997 1.000 288 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MPL(4), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1), THPO(1) 5186677 106 52 97 26 15 25 1 57 5 3 0.322 0.997 1.000 289 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(1), JAK1(2), JAK2(7), JAK3(4), STAT1(2), STAT5A(2), STAT5B(1) 3050502 19 15 19 8 2 5 0 7 3 2 0.913 0.998 1.000 290 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 CBL(7), CFLAR(1), FOS(1), GRB2(2), IL2RA(3), IL2RB(1), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), MAPK3(1), NMI(1), PIK3CA(56), PIK3R1(9), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3) 5852771 108 49 99 27 15 25 1 53 11 3 0.358 0.998 1.000 291 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), GPT(1), LDHA(4), LDHB(3), MAPK14(1), NCL(2) 1499594 15 12 15 6 4 6 0 5 0 0 0.767 0.998 1.000 292 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2) 4350842 26 12 26 4 2 13 0 7 4 0 0.137 0.998 1.000 293 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(1), POLB(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLG(1), POLH(3), POLI(7), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM2(1), REV1(3), REV3L(9), RFC5(2) 7033599 52 25 50 10 12 18 0 9 12 1 0.243 0.998 1.000 294 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(4), CDK5(1), CSNK1D(1), GSK3B(1), MAPT(1) 1350858 8 6 7 4 4 1 0 3 0 0 0.809 0.998 1.000 295 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1) 3468902 24 11 26 6 7 10 0 5 2 0 0.367 0.998 1.000 296 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(1), RDH12(1) 804597 2 1 2 1 1 1 0 0 0 0 0.778 0.998 1.000 297 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(7), AR(6), ESR1(1), ESRRA(9), HNF4A(4), NPM1(1), NR0B1(1), NR1D1(1), NR1D2(3), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR3C1(3), NR4A2(3), PGR(1), PPARD(1), RARA(1), RARB(2), ROR1(4), RORC(1), RXRB(1), RXRG(1), VDR(1) 6741368 57 27 50 12 16 10 0 19 12 0 0.200 0.998 1.000 298 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IL10(1), IL12A(1), IL2(1), IL6(2), IL7(1), IL8(1), TGFB2(4), TNF(1) 2188764 17 7 18 6 5 7 0 2 3 0 0.641 0.998 1.000 299 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IL10(1), IL12A(1), IL16(4), IL2(1), IL6(2), IL8(1), IL9(1), TNF(1) 1666062 13 4 13 7 3 7 0 1 2 0 0.885 0.998 1.000 300 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 ERCC3(1), GTF2B(1), GTF2F2(1), GTF2H1(2), MNAT1(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3B(6), POLR3E(3), POLR3K(1), TAF12(1), TAF5(2), TAF6(1), TAF7(1), TAF9(1) 6077764 34 18 34 6 13 10 0 4 7 0 0.112 0.998 1.000 301 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), SHMT1(1), TPO(7) 1882215 18 13 18 7 6 6 1 2 3 0 0.698 0.998 1.000 302 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), PAK1(1), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5) 4757676 40 24 40 10 8 12 2 15 3 0 0.338 0.998 1.000 303 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2C1(1), MANBA(1) 2613226 17 11 17 6 6 3 0 4 4 0 0.677 0.999 1.000 304 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR1(1), GOSR2(1), SNAP25(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX5(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1) 2734022 16 6 16 4 5 5 0 3 3 0 0.432 0.999 1.000 305 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 ACHE(2), CHAT(1), DBH(1), GAD1(2), HDC(6), MAOA(2), PAH(2), SLC18A3(1), TPH1(2) 2204404 19 15 19 9 5 10 0 2 2 0 0.865 0.999 1.000 306 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), MTHFR(1), PRDX6(1), SHMT1(1), TPO(7) 1868579 18 13 18 6 7 6 1 2 2 0 0.595 0.999 1.000 307 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C8B(1), C9(1), MASP1(4) 4059879 29 14 31 6 9 12 0 6 2 0 0.193 0.999 1.000 308 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(2), ATP7B(2), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(2), SHMT1(1) 6710523 38 24 37 9 7 15 0 13 3 0 0.268 0.999 1.000 309 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(1), GNAQ(1), MAPK14(1), MAPK8(6), PLCG1(2), PRKCA(3) 2351619 15 10 15 5 5 4 1 4 1 0 0.633 0.999 1.000 310 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(4), CREBBP(13), DUSP1(1), EP300(14), IKBKB(2), IL1B(1), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(2), MAPK14(1), MYD88(1), NFKB1(3), NR3C1(3), RELA(1), TGFBR1(3), TGFBR2(2), TLR2(5), TNF(1) 4940131 62 30 59 17 14 10 3 25 10 0 0.389 0.999 1.000 311 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(6), CPT1A(3), LEPR(6), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1) 2589141 25 15 25 8 9 6 0 8 2 0 0.658 0.999 1.000 312 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1), MASP1(4) 4137516 28 14 30 7 9 11 0 6 2 0 0.306 0.999 1.000 313 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(4), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF13B(1), TNFSF13B(1), TRAF3(2), TRAF5(2) 2362416 21 10 21 8 5 5 1 7 3 0 0.797 0.999 1.000 314 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2) 8106283 49 25 49 12 10 21 0 11 7 0 0.181 0.999 1.000 315 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), CAMKK2(1) 1953290 9 5 9 3 1 5 0 2 1 0 0.705 0.999 1.000 316 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT2(1), AKT3(1), APAF1(4), ATM(37), BAX(2), BIRC2(2), BIRC3(7), CAPN2(2), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IRAK3(2), IRAK4(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1), TP53(109) 13819297 298 104 247 56 73 70 6 99 46 4 0.000624 0.999 1.000 317 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), BDKRB2(2), CAV1(1), CHRNA1(3), FLT1(9), FLT4(2), KDR(4), NOS3(2), PDE3A(2), PDE3B(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKG1(6), PRKG2(2), RYR2(16) 6070893 63 38 69 18 13 15 1 27 7 0 0.366 0.999 1.000 318 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(7), PGM1(2), PYGL(2), PYGM(2) 2239402 13 9 13 5 8 2 0 2 1 0 0.663 0.999 1.000 319 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(1), GTF2F1(2), NCOA1(2), NCOA2(2), NCOA3(7), NCOR2(6), POLR2A(2), RARA(1) 3932288 25 16 25 8 9 8 0 4 4 0 0.649 0.999 1.000 320 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SPN(2), TGFB2(4), TNF(1), TNFRSF8(1), TNFSF8(2) 2136358 17 12 17 8 4 6 0 5 2 0 0.817 0.999 1.000 321 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), AKT3(1), GRB2(2), IARS(1), IL13RA1(1), IL2RG(1), INPP5D(2), JAK1(2), JAK2(7), JAK3(4), PI3(1), PIK3CA(56), PPP1R13B(1), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2) 6105804 93 46 84 23 8 24 1 53 5 2 0.407 1.000 1.000 322 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(1), ALAS2(2), BLVRB(1), COX15(3), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(1), HCCS(2), HMBS(1), HMOX2(2), MMAB(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UROD(1) 6952068 48 23 48 9 10 23 0 10 5 0 0.0965 1.000 1.000 323 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(2), ATF2(1), EGFR(11), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), MEF2A(2), PAK1(1), PRKCA(3), RAF1(3), SHC1(1), SOS1(5) 5740220 51 29 52 13 9 15 1 22 4 0 0.331 1.000 1.000 324 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(4), PGAP1(3), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2) 3987704 28 13 29 9 6 13 0 4 5 0 0.616 1.000 1.000 325 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1) 4032729 23 11 23 3 10 10 0 2 1 0 0.0667 1.000 1.000 326 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), CHIT1(2), CMAS(3), CYB5R1(2), CYB5R3(1), GFPT1(1), GFPT2(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NANS(1), NPL(1), PGM3(2) 4915368 30 18 30 9 13 8 1 5 3 0 0.433 1.000 1.000 327 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT2(1), AKT3(1), GRB2(2), GSK3B(1), IRS1(4), JAK1(2), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PPP1R13B(1), RAF1(3), SHC1(1), SOS1(5), SOS2(2) 5818174 97 49 88 25 12 23 1 50 8 3 0.379 1.000 1.000 328 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), SELE(2), SELP(2) 2579976 18 11 20 8 3 9 0 2 4 0 0.799 1.000 1.000 329 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2) 2251392 6 5 6 6 1 2 1 1 1 0 0.990 1.000 1.000 330 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CD8A(1), CIITA(3), CTSB(3), CTSL1(2), HLA-A(3), HLA-B(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(8), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(2), HSPA5(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KIR3DL3(1), KLRC3(1), KLRC4(1), LGMN(2), NFYA(2), RFX5(1), TAP1(2), TAP2(1), TAPBP(2) 7207172 69 33 63 21 14 21 2 13 13 6 0.641 1.000 1.000 331 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), EPX(1), ESCO1(6), ESCO2(5), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), MYST3(6), MYST4(8), PRDX6(1), SH3GLB1(1), TAT(2), TPO(7) 5795968 60 30 56 16 12 21 2 13 12 0 0.437 1.000 1.000 332 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(2), NTRK1(1), PIR(1), PSMA7(1), WASF1(3), WASF3(3), WASL(2) 2663951 19 8 19 6 6 6 0 4 3 0 0.615 1.000 1.000 333 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACSS1(1), ACSS2(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3) 2321219 11 10 11 8 1 4 0 5 1 0 0.986 1.000 1.000 334 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 GNS(3), HEXA(1), HEXB(2), LCT(7), NAGLU(1) 2363965 14 8 14 7 5 4 0 3 2 0 0.842 1.000 1.000 335 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2) 2358168 7 6 7 6 2 2 1 1 1 0 0.979 1.000 1.000 336 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), HADHA(2) 2071514 12 8 11 7 1 3 1 4 3 0 0.962 1.000 1.000 337 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), BIN1(3), DNM1(3), EPN1(1), EPS15(3), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(1) 3767637 25 14 25 8 10 8 1 3 3 0 0.470 1.000 1.000 338 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 2135219 7 4 8 3 3 3 0 1 0 0 0.718 1.000 1.000 339 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(2), MAPK3(1), MEF2A(2), NTRK1(1), PIK3CA(56), PIK3R1(9), PLCG1(2), SHC1(1) 3101538 74 46 66 22 6 15 1 46 4 2 0.704 1.000 1.000 340 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(3), AGT(2), AGTR1(2), AGTR2(2), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(3), REN(2) 3576498 30 12 30 9 9 13 0 6 2 0 0.383 1.000 1.000 341 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(2), MAP2K5(2), MAPK8(6), PLD1(3), PLD2(3), RAF1(3), RASAL1(2), TEC(2), VAV1(2) 4613190 29 13 29 8 10 9 1 8 1 0 0.410 1.000 1.000 342 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F3(1), F5(7), F7(1), FGA(4), FGB(2), PROS1(3), TFPI(3) 2794202 22 8 22 8 6 7 0 7 2 0 0.713 1.000 1.000 343 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(6), ACADL(2), ACADM(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ECHS1(1), EHHADH(2), HADHA(2), LDHA(4), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1) 5826630 46 23 45 12 10 14 1 12 9 0 0.415 1.000 1.000 344 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1) 3201897 20 13 20 9 8 3 0 5 4 0 0.826 1.000 1.000 345 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(1), ENPP3(2), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(3), NT5E(1) 2582891 14 5 14 9 3 5 0 2 4 0 0.982 1.000 1.000 346 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PIK3CB(1), PLD1(3), PLD2(3) 6926509 41 23 48 10 16 10 1 8 5 1 0.186 1.000 1.000 347 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPP(1), ENPP3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), TYR(3) 2629931 12 10 12 7 5 3 1 1 1 1 0.931 1.000 1.000 348 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP5(1), ACPP(1), ALPPL2(1), CYP3A43(3), CYP3A7(2), DHRS2(1), PON1(1), PON2(1), PON3(4) 2870024 15 11 13 6 4 5 0 4 1 1 0.716 1.000 1.000 349 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(13), EP300(14), IKBKB(2), NFKB1(3), RELA(1), TNF(1) 3810059 38 20 36 11 10 7 2 13 6 0 0.487 1.000 1.000 350 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(1), CHUK(4), GH1(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RELA(1), YWHAH(2) 2437220 77 45 68 23 10 17 1 43 4 2 0.627 1.000 1.000 351 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(1), GRB2(2), INSR(1), IRS1(4), JAK2(7), MAP2K1(2), MAPK3(1), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SLC2A4(1), SOS1(5), STAT5A(2), STAT5B(1) 5561462 101 51 92 28 15 21 1 55 6 3 0.553 1.000 1.000 352 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG5(1), BECN1(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), PIK3C3(4), PIK3R4(1), PRKAA1(1), PRKAA2(5), ULK1(2) 3471913 22 13 22 7 4 7 0 7 4 0 0.686 1.000 1.000 353 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 62 AGTR1(2), AGTR2(2), ATP8A1(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(6), FPR1(3), FSHR(3), GALR1(1), GPR77(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), NMBR(1), NPY5R(2), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR4(2), TACR3(7), TRHR(2), TSHR(4) 8287907 88 45 87 28 36 24 2 23 3 0 0.165 1.000 1.000 354 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNGT1(1), HTR2C(2), PLCB1(1), TUB(1) 1237695 6 3 6 4 1 3 0 1 1 0 0.923 1.000 1.000 355 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(1), CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PRIM2(1), RFC5(2), RRM1(1), TK2(1), TXNRD2(1), TYMS(2), UMPS(1), UPB1(2), UPP2(2), UPRT(1) 13846234 91 46 91 16 25 33 2 18 13 0 0.00980 1.000 1.000 356 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1) 1408598 7 5 7 4 2 3 0 1 1 0 0.868 1.000 1.000 357 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(1), MAN1A1(2), MGAT1(2), MGAT4A(1), MGAT4B(1), RPN2(1) 3118050 15 12 15 9 4 3 0 4 4 0 0.952 1.000 1.000 358 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(8), FYN(2), ITGB1(1), MAP2K1(2), MAPK3(1), MYLK(4), PIK3CA(56), PIK3R1(9), RAF1(3), ROCK1(8), SHC1(1), TLN1(2) 6486884 97 52 85 27 11 23 1 53 7 2 0.517 1.000 1.000 359 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTR2(1), ACTR3(1), ANGPTL2(1), CDC42(1), FLNA(7), FLNC(3), FSCN3(1), LIMK1(1), MYH2(5), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2) 7459583 59 29 59 16 22 14 0 12 11 0 0.234 1.000 1.000 360 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), PLCB1(1), PRKCA(3), RELA(1) 1430443 9 5 9 7 6 2 0 0 1 0 0.956 1.000 1.000 361 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), CYP11A1(2), EDNRA(1), EDNRB(6), PLA2G4A(3), PRL(1), PTGDR(2), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2) 3533294 22 16 21 9 9 7 0 3 3 0 0.782 1.000 1.000 362 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(6), EPHB1(5), FYN(2), ITGB1(1), L1CAM(3), SELP(2) 2562900 21 16 24 9 8 7 0 3 3 0 0.789 1.000 1.000 363 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2) 6377521 50 25 50 13 15 15 1 14 5 0 0.293 1.000 1.000 364 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(7), CSF1R(1), EGF(1), EGFR(11), GRB2(2), MET(7), PDGFRA(8), PRKCA(3), SH3GLB1(1) 3453045 41 21 41 14 9 9 1 20 2 0 0.702 1.000 1.000 365 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(7), ATP4A(3), ATP5A1(3), ATP5C1(3), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), COX15(3), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(2), TCIRG1(1), UQCRC2(2) 9583405 63 31 62 15 19 20 0 20 4 0 0.134 1.000 1.000 366 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(1), GNAI1(2), GNGT1(1), ITGB1(1), MAP2K1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(3), PTGS1(1), RAF1(3), SYK(3), TBXAS1(2) 4215517 24 15 24 9 8 5 0 5 6 0 0.753 1.000 1.000 367 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), APOA4(2), APOC1(1), APOC2(1), CETP(1), CYP7A1(1), HMGCR(1), LDLR(2), LIPC(1), LRP1(4), SCARB1(1) 4476099 20 9 20 7 10 5 1 2 2 0 0.557 1.000 1.000 368 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(2), C5(5), C6(3), C7(1), IL6(2), IL8(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(3) 4164554 35 18 37 12 12 11 0 4 8 0 0.557 1.000 1.000 369 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(2), GOT1(1), PAH(2), TAT(2) 1479656 9 6 9 4 2 5 0 0 2 0 0.754 1.000 1.000 370 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), GNAS(4), GNGT1(1), NFKB1(3), NOS3(2), NR3C1(3), PIK3CA(56), PIK3R1(9), RELA(1) 2818906 80 48 70 25 12 16 3 43 4 2 0.697 1.000 1.000 371 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(2), AGTR1(2), AGTR2(2), BDKRB2(2), KNG1(1), NOS3(2), REN(2) 1496311 15 9 15 6 4 7 0 2 2 0 0.607 1.000 1.000 372 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(1), CASP3(1), CASP8(1), INSR(1), MAGI1(4), MAGI2(7), WWP1(3), WWP2(1) 3980375 20 9 20 6 6 2 1 6 5 0 0.663 1.000 1.000 373 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2A1L(4), GTF2B(1), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(3), TAF1(6), TAF12(1), TAF1L(16), TAF2(3), TAF4(2), TAF4B(2), TAF5(2), TAF5L(1), TAF6(1), TAF7(1), TAF7L(2), TAF9(1) 6275731 52 30 50 14 14 12 1 15 10 0 0.409 1.000 1.000 374 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), ACADS(1), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), EHHADH(2), HADHA(2), SLC25A20(1) 2914240 17 9 16 8 4 5 0 5 3 0 0.883 1.000 1.000 375 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(1), GOT1(1), PAH(2), TAT(2), YARS2(1) 1537082 9 5 9 4 1 7 0 0 1 0 0.790 1.000 1.000 376 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(2), GAB2(1), GRB2(2), INPP5D(2), KRAS(63), LAT(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MS4A2(3), NRAS(11), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PRKCA(3), PRKCE(2), RAF1(3), SOS1(5), SOS2(2), SYK(3), TNF(1), VAV1(2), VAV2(2), VAV3(3) 11743786 238 97 176 51 34 103 4 76 19 2 0.0183 1.000 1.000 377 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP3A43(3), CYP3A7(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1) 4121569 26 11 26 9 12 5 1 6 2 0 0.560 1.000 1.000 378 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CDH1(12), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2) 8427999 98 45 96 26 27 26 1 33 11 0 0.219 1.000 1.000 379 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CDH1(12), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2) 8427999 98 45 96 26 27 26 1 33 11 0 0.219 1.000 1.000 380 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT2(1), ACYP1(1), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), GCDH(2), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1) 4342022 36 19 34 11 6 13 0 13 4 0 0.623 1.000 1.000 381 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(4), CALCRL(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(3), EMR1(4), EMR2(4), GLP1R(5), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(4), LPHN3(4), SCTR(1), VIPR1(1) 4487325 43 23 47 15 18 13 0 8 4 0 0.409 1.000 1.000 382 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1) 1667795 15 8 15 6 6 3 0 3 3 0 0.585 1.000 1.000 383 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(4), ATM(37), ATR(10), BAI1(2), BAX(2), CASP3(1), CASP8(1), CASP9(1), CCNB3(7), CCNE2(1), CCNG1(1), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), DDB2(1), FAS(2), GTSE1(3), IGFBP3(2), MDM4(1), PTEN(47), RFWD2(1), SERPINB5(4), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53(109), TP53I3(2), TSC2(2), ZMAT3(3) 10416759 261 104 215 60 61 65 5 86 42 2 0.0536 1.000 1.000 384 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(37), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(3), FSHR(3), MLH1(6), MSH5(1), NCOR1(5), NRIP1(1), PGR(1), PRLR(2), SMPD1(1), VDR(1), ZP2(2) 5901079 69 37 67 20 13 18 3 24 9 2 0.478 1.000 1.000 385 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(4), ACTN2(4), ITGB1(1), ITGB3(4), SPTAN1(5), TLN1(2) 4678961 22 13 22 8 8 7 1 2 4 0 0.635 1.000 1.000 386 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACOX3(2), ELOVL6(1), FADS2(2), HADHA(2) 1872007 7 7 7 6 3 3 0 0 1 0 0.957 1.000 1.000 387 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(5), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(3) 5874736 41 21 39 13 10 12 1 12 6 0 0.571 1.000 1.000 388 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), NDST1(1), NDST2(1), NDST3(4) 3392649 24 14 24 9 7 7 1 7 2 0 0.681 1.000 1.000 389 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUL(1), HAL(1) 3304266 16 7 16 6 5 6 0 3 2 0 0.701 1.000 1.000 390 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(2), GNAQ(1), GNAS(4), GNGT1(1), LIMK1(1), MAP2K1(2), MAPK3(1), PIK3C2G(2), PLCB1(1), PPP1R12B(5), PRKCA(3), RAF1(3), ROCK2(5) 4128496 32 20 33 10 8 7 2 5 10 0 0.673 1.000 1.000 391 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(4), CDC7(2), DIAPH2(4), GMNN(2), MCM10(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), NACA(5), PCNA(3), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), RFC1(5), RFC2(1), RFC5(2), RPA4(1), UBB(1), UBC(1) 8336337 52 27 49 12 11 20 0 15 6 0 0.267 1.000 1.000 392 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), CD3G(1), FOS(1), FYN(2), GRB2(2), LAT(1), LCK(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PIK3CA(56), PIK3R1(9), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), PTPN7(1), RAF1(3), RASA1(4), RELA(1), SHC1(1), SOS1(5), VAV1(2) 7953906 127 62 118 30 27 33 2 54 9 2 0.119 1.000 1.000 393 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(3), IMPDH1(1), POLB(2), POLD1(2), POLG(1), RRM1(1) 2024182 10 7 10 5 4 2 0 3 1 0 0.850 1.000 1.000 394 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), DARS(1), EPRS(4), FARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1) 5674133 27 14 27 8 4 9 1 8 5 0 0.653 1.000 1.000 395 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(1), ALOX15(1), CYP4F3(1), EPX(1), GGT1(2), LPO(1), MPO(4), PLA2G4A(3), PLA2G6(2), PRDX1(1), PRDX6(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2), TPO(7) 4577993 32 21 32 10 15 7 1 2 7 0 0.503 1.000 1.000 396 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUD2(2), GLUL(1), HAL(1) 3674511 18 9 18 8 5 8 0 3 2 0 0.820 1.000 1.000 397 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), LMNA(1), NFKB1(3), RELA(1), SPTAN1(5), TNFRSF10B(4), TNFSF10(1) 5556770 39 17 37 11 13 11 0 7 8 0 0.498 1.000 1.000 398 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), ESCO1(6), ESCO2(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), MYST3(6), MYST4(8), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SH3GLB1(1), TAT(2), TPO(7), TYR(3) 9798316 86 40 81 26 13 29 3 22 19 0 0.575 1.000 1.000 399 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), EPRS(4), GLUD2(2), GOT1(1), LAP3(1), NOS1(8), NOS3(2), OAT(1), OTC(3), P4HA1(1), P4HA3(2), RARS(2), RARS2(3) 5941862 53 23 53 16 16 19 2 8 8 0 0.422 1.000 1.000 400 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT2(1), AKT3(1), CASP9(1), CDC42(1), KDR(4), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NOS3(2), NRAS(11), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCA(3), PRKCG(5), PTGS2(1), RAF1(3), SH2D2A(1), SPHK1(1) 11380620 209 97 145 49 36 91 2 65 13 2 0.0516 1.000 1.000 401 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(1), CDC42(1), DAXX(4), DDIT3(1), GRB2(2), HSPB2(1), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), PLA2G4A(3), RPS6KA5(3), SHC1(1), STAT1(2), TGFB2(4), TGFBR1(3) 6067967 47 22 48 14 9 15 0 17 6 0 0.504 1.000 1.000 402 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PGM2(1), PMM1(2), RDH11(1), RDH12(1), SORD(2) 6198694 36 19 36 11 14 13 1 7 1 0 0.351 1.000 1.000 403 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(9), CD22(2), CD72(1), CD79B(1), CHUK(4), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), KRAS(63), LILRB3(2), MALT1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), NRAS(11), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASGRP3(1), SYK(3), VAV1(2), VAV2(2), VAV3(3) 12115613 217 97 157 52 35 103 1 64 12 2 0.0616 1.000 1.000 404 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(4), ATF4(2), BRAF(14), CACNA1C(3), CAMK2D(1), CAMK4(3), CREBBP(13), EP300(14), GNAQ(1), GRIA1(3), GRIA2(6), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), NRAS(11), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), RAP1A(1), RAPGEF3(2), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3) 16281758 229 101 178 51 43 105 4 55 20 2 0.00671 1.000 1.000 405 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), TAT(2), TPO(7), TYR(3) 5203396 49 30 45 18 6 16 3 10 14 0 0.833 1.000 1.000 406 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(1), EGFR(11), FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2) 6485980 120 58 111 30 19 30 2 60 6 3 0.275 1.000 1.000 407 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNA1(1), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(2), IRAK3(2), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TGFB2(4), TNF(1) 4886545 42 13 42 13 12 13 2 11 4 0 0.534 1.000 1.000 408 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5) 2840034 16 9 15 6 3 5 0 5 3 0 0.731 1.000 1.000 409 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), AKAP10(1), AKAP11(4), AKAP12(6), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(7), AKAP7(1), AKAP8(1), AKAP9(9), ARHGEF1(2), GNA12(1), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAZ(2), GNG3(1), GNG4(1), GNGT1(1), IL18BP(3), ITPR1(2), KRAS(63), NRAS(11), PDE1A(2), PDE1B(1), PDE1C(2), PDE4B(4), PDE4D(2), PDE7A(1), PDE7B(2), PDE8B(3), PLCB3(1), PPP3CA(2), PPP3CC(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKD3(4), RHOA(1), SLC9A1(3), USP5(1) 19382234 217 90 169 48 46 109 1 35 25 1 0.00683 1.000 1.000 410 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), LPA(2), MAP2K4(4), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(3), PLD2(3), RDX(3), ROCK1(8), ROCK2(5), SERPINA4(5) 8141239 65 27 65 19 21 22 1 13 8 0 0.485 1.000 1.000 411 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2) 3110841 13 7 13 6 4 5 0 3 1 0 0.736 1.000 1.000 412 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2) 3191546 13 7 13 6 4 5 0 3 1 0 0.741 1.000 1.000 413 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(13), CDR1(3), DGKI(4), FAU(1), IL6ST(1), PIGK(2), RPL10(1), RPL11(2), RPL19(1), RPL22(1), RPL28(1), RPL5(1), RPL6(2), RPL7(1), RPL9(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS4X(2), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), SLC36A2(3), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1) 8506880 62 35 62 15 18 17 1 17 9 0 0.328 1.000 1.000 414 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(2), EPHB2(1), GRB2(2), ITPKB(1), MAP2K1(2), MAP2K2(1), NFKB1(3), NFKB2(2), NFKBIE(1), PI3(1), PIK3CA(56), PIK3CD(1), PIK3R1(9), PLCG2(5), PPP1R13B(1), RAF1(3), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2) 8483359 116 52 107 30 22 28 1 56 7 2 0.282 1.000 1.000 415 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(2), FLOT1(1), GRB2(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(8), ITPR3(5), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PLCG2(5), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(9), RAF1(3), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2) 11754043 144 59 142 35 31 41 1 55 13 3 0.121 1.000 1.000 416 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(3), EEF1B2(2), EEF1D(3), EEF2K(1), EIF2AK2(2), EIF2AK3(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(2), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(7), PAIP1(3) 7177954 37 22 36 11 10 10 1 11 5 0 0.610 1.000 1.000 417 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), HSD17B10(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(2), SETDB1(1), SHMT1(1), SPCS1(1), SUV39H2(1), TMLHE(3) 9471424 56 24 54 17 18 16 1 12 9 0 0.469 1.000 1.000 418 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), NT5E(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), RRM1(1), TK2(1), TYMS(2), UMPS(1), UPB1(2) 9563213 56 31 55 16 13 18 2 15 8 0 0.385 1.000 1.000 419 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDH7A1(2), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PGM1(2), PGM3(2), PKLR(1) 9647469 71 32 67 23 21 19 2 17 12 0 0.508 1.000 1.000 420 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT2(1), AKT3(1), CARD11(9), CBL(7), CBLB(3), CD28(1), CD3D(1), CD3G(1), CD8A(1), CDC42(1), CDK4(1), CHUK(4), CTLA4(1), FOS(1), FYN(2), GRAP2(4), GRB2(2), IKBKB(2), IL10(1), IL2(1), ITK(5), KRAS(63), LAT(1), LCK(1), LCP2(1), MALT1(1), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), NRAS(11), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCQ(1), PTPRC(9), RASGRP1(1), RHOA(1), SOS1(5), SOS2(2), TEC(2), TNF(1), VAV1(2), VAV2(2), VAV3(3) 16681566 270 99 210 61 50 120 1 81 16 2 0.0230 1.000 1.000 421 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1) 8214854 63 32 59 22 21 14 2 15 11 0 0.630 1.000 1.000 422 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1) 8214854 63 32 59 22 21 14 2 15 11 0 0.630 1.000 1.000 423 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ENPP3(2), G6PC(1), GANAB(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), PGM1(2), PGM3(2), PYGL(2), PYGM(2), SI(4), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1) 9780094 52 28 51 16 15 14 0 14 9 0 0.513 1.000 1.000 424 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH4A1(1), AMD1(1), AOC3(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), GOT1(1), MAOA(2), MAOB(3), NOS1(8), NOS3(2), OAT(1), ODC1(3), OTC(3), P4HA1(1), P4HA3(2), RARS(2) 7366444 63 26 62 21 22 18 3 9 11 0 0.465 1.000 1.000 425 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1(3), ACVR1B(3), ACVR1C(2), ACVR2A(2), ACVR2B(2), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BMPR1B(1), BMPR2(3), CHRD(2), CREBBP(13), CUL1(1), DCN(2), EP300(14), FST(1), GDF5(2), GDF6(1), INHBA(4), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(3), RBL2(2), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RPS6KB2(2), SMAD2(7), SMAD3(5), SMAD4(25), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(1), TGFB2(4), TGFBR1(3), TGFBR2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNF(1), ZFYVE16(3), ZFYVE9(5) 16466505 175 72 169 39 47 48 2 48 29 1 0.0340 1.000 1.000 426 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), EP400(4), ERCC3(1), GGH(1), IFIH1(2), MOV10L1(7), RAD54B(2), RUVBL2(2), SETX(10), SKIV2L2(2), SMARCA2(3), SMARCA5(5) 10438511 61 25 61 18 17 17 1 13 13 0 0.452 1.000 1.000 427 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(3), ACOX2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), CYP7A1(1), CYP8B1(1), EHHADH(2), FABP2(1), FABP7(1), FADS2(2), GK2(3), HMGCS2(1), ME1(3), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(4), UBC(1) 11056050 57 25 56 18 23 17 1 11 5 0 0.407 1.000 1.000 428 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(2), AGT(2), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(3), CREBBP(13), F2(1), FKBP1A(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(2), MAPK14(1), MAPK3(1), MAPK8(6), MYH2(5), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PIK3CA(56), PIK3R1(9), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAF1(3) 8175581 135 61 124 37 26 31 4 60 12 2 0.332 1.000 1.000 429 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 241 ACVR1B(3), ACVR1C(2), AKT2(1), AKT3(1), ATF2(1), ATF4(2), BDNF(1), BRAF(14), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CACNA2D1(3), CACNA2D3(3), CACNA2D4(1), CACNB2(2), CACNB3(1), CACNB4(1), CACNG2(1), CACNG3(4), CACNG5(1), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(4), DAXX(4), DDIT3(1), DUSP1(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(2), ECSIT(1), EGF(1), EGFR(11), ELK4(1), FAS(2), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FLNA(7), FLNB(4), FLNC(3), FOS(1), GNA12(1), GRB2(2), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MAPT(1), MKNK1(2), MKNK2(1), MOS(2), NF1(20), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(11), NTRK1(1), NTRK2(2), PAK1(1), PAK2(1), PDGFB(1), PDGFRA(8), PDGFRB(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPM1A(1), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PPP5C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTPN5(1), PTPN7(1), PTPRR(5), RAF1(3), RAP1A(1), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KA6(3), RRAS2(3), SOS1(5), SOS2(2), STK4(1), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), TP53(109), ZAK(4) 44570908 559 119 493 132 153 168 13 151 71 3 0.000183 1.000 1.000 430 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(4), ACTN2(4), ACTN4(1), APC(153), ARHGEF1(2), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARHGEF7(2), ARPC2(1), ARPC5L(2), BAIAP2(1), BCAR1(1), BDKRB1(1), BDKRB2(2), BRAF(14), CDC42(1), CHRM2(4), CHRM3(2), CHRM5(1), CSK(2), CYFIP1(1), DIAPH2(4), DIAPH3(2), DOCK1(2), EGF(1), EGFR(11), F2(1), FGD1(3), FGD3(1), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FN1(6), GIT1(1), GNA12(1), GRLF1(1), IQGAP1(7), IQGAP2(7), IQGAP3(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), KRAS(63), LIMK1(1), LIMK2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MOS(2), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(3), MYLK(4), MYLK2(1), NCKAP1(2), NCKAP1L(4), NRAS(11), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFRA(8), PDGFRB(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIP5K1B(1), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), RAF1(3), RDX(3), RHOA(1), ROCK1(8), ROCK2(5), RRAS2(3), SLC9A1(3), SOS1(5), SOS2(2), SSH1(2), SSH3(1), TIAM1(8), TIAM2(2), VAV1(2), VAV2(2), VAV3(3), VCL(1), WASF1(3), WASL(2) 45247219 618 119 527 162 90 190 9 166 122 41 0.0608 1.000 1.000 431 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(37), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDAN1(2), CDC14A(4), CDC14B(1), CDC25C(1), CDC6(4), CDC7(2), CDH1(12), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), E2F3(1), E2F6(3), EP300(14), ESPL1(1), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MPEG1(2), MPL(4), PCNA(3), PLK1(4), PRKDC(5), PTPRA(1), RB1(16), RBL1(3), SMAD4(25), TP53(109) 18428924 297 107 250 69 77 64 6 101 47 2 0.0325 1.000 1.000 432 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(4), ANAPC1(1), ANAPC4(4), ANAPC5(1), ATM(37), ATR(10), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC25C(1), CDC27(5), CDC6(4), CDC7(2), CDK4(1), CDKN1B(2), CDKN2A(2), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(1), DBF4(3), E2F3(1), EP300(14), ESPL1(1), FZR1(1), GSK3B(1), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), PCNA(3), PLK1(4), PRKDC(5), RB1(16), RBL1(3), RBL2(2), RBX1(1), SMAD2(7), SMAD3(5), SMAD4(25), SMC1B(3), TGFB2(4), TP53(109), YWHAH(2) 22813359 336 107 287 86 81 81 8 106 58 2 0.149 1.000 1.000 433 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(4), ABLIM1(3), ABLIM3(2), ARHGEF12(2), CDC42(1), CDK5(1), CXCR4(1), DCC(6), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(2), EPHA1(4), EPHA3(9), EPHA4(6), EPHA5(8), EPHA6(3), EPHA7(7), EPHA8(3), EPHB1(5), EPHB2(1), EPHB4(4), EPHB6(3), FES(1), FYN(2), GNAI1(2), GSK3B(1), ITGB1(1), KRAS(63), L1CAM(3), LIMK1(1), LIMK2(2), LRRC4C(3), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NGEF(2), NRAS(11), NRP1(1), NTN1(1), NTN4(3), NTNG1(3), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLXNA1(2), PLXNA2(5), PLXNA3(2), PLXNB1(2), PLXNB3(3), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASA1(4), RGS3(3), RHOA(1), ROBO1(2), ROBO2(6), ROBO3(2), ROCK1(8), ROCK2(5), SEMA3A(4), SEMA3C(1), SEMA3D(7), SEMA3E(5), SEMA3F(1), SEMA3G(2), SEMA4A(1), SEMA4B(2), SEMA4D(1), SEMA4F(5), SEMA4G(2), SEMA5A(2), SEMA5B(4), SEMA6A(1), SEMA6B(2), SEMA6C(2), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(4), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(3), UNC5B(2), UNC5C(4), UNC5D(1) 30085477 333 106 290 78 98 129 3 68 35 0 0.00264 1.000 1.000 434 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(3), AKT2(1), AKT3(1), BRAF(14), CAMK2D(1), CBL(7), CBLB(3), CDKN1B(2), EGF(1), EGFR(11), ERBB2(9), ERBB3(4), ERBB4(9), GRB2(2), GSK3B(1), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), NCK1(1), NCK2(1), NRAS(11), NRG1(7), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), RAF1(3), RPS6KB2(2), SHC1(1), SOS1(5), SOS2(2), STAT5A(2), STAT5B(1) 17211535 304 104 235 75 48 120 4 107 23 2 0.0823 1.000 1.000 435 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ASH1L(13), CASK(2), CDC42(1), CDK4(1), CGN(3), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CTTN(1), EPB41L1(1), EPB41L3(4), EXOC4(3), GNAI1(2), HCLS1(1), IGSF5(2), INADL(3), KRAS(63), LLGL1(1), LLGL2(2), MAGI1(4), MAGI2(7), MAGI3(2), MLLT4(4), MPDZ(3), MPP5(1), MYH1(9), MYH10(2), MYH11(9), MYH13(2), MYH14(3), MYH15(6), MYH2(5), MYH3(7), MYH4(2), MYH6(7), MYH7(4), MYH7B(4), MYH8(5), MYH9(3), MYL9(3), NRAS(11), PARD3(2), PARD6A(1), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PTEN(47), RHOA(1), RRAS2(3), SPTAN1(5), TJAP1(2), TJP1(4), TJP3(1), YES1(1), ZAK(4) 31647271 347 104 297 107 72 148 2 91 33 1 0.512 1.000 1.000 436 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 BRAF(14), CASP3(1), FAS(2), FCGR3A(1), FYN(2), GRB2(2), GZMB(1), HLA-A(3), HLA-B(3), HLA-G(1), ICAM2(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KLRC3(1), KLRK1(1), KRAS(63), LAT(1), LCK(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MICB(3), NCR1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NRAS(11), PAK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRF1(1), PRKCA(3), PRKCG(5), PTPN11(10), RAF1(3), SH3BP2(1), SHC1(1), SOS1(5), SOS2(2), SYK(3), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP3(1), VAV1(2), VAV2(2), VAV3(3) 18581787 285 104 218 79 45 116 4 95 21 4 0.229 1.000 1.000 437 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRB1(2), CSNK1D(1), DRD2(2), EGF(1), EGFR(11), GJA1(4), GJD2(1), GNAI1(2), GNAQ(1), GNAS(4), GRB2(2), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(5), HTR2C(2), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR1(2), NPR2(2), NRAS(11), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), SOS1(5), SOS2(2), TJP1(4), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1) 21453459 271 101 224 63 61 122 6 60 20 2 0.00275 1.000 1.000 438 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 125 ACACA(6), ACACB(3), AKT2(1), AKT3(1), BRAF(14), CBL(7), CBLB(3), EXOC7(1), FBP2(1), FLOT1(1), G6PC(1), G6PC2(1), GCK(3), GRB2(2), GSK3B(1), GYS1(1), GYS2(4), IKBKB(2), INPP5D(2), INSR(1), IRS1(4), IRS4(6), KRAS(63), LIPE(2), MAP2K1(2), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MKNK1(2), MKNK2(1), NRAS(11), PCK1(3), PDE3A(2), PDE3B(2), PFKM(3), PFKP(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PKLR(1), PPP1CB(1), PPP1CC(1), PPP1R3A(7), PPP1R3C(2), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCI(1), PRKCZ(1), PTPN1(1), PTPRF(2), PYGL(2), PYGM(2), RAF1(3), RHEB(1), RPS6(1), RPS6KB2(2), SHC1(1), SLC2A4(1), SOCS2(2), SOCS4(1), SORBS1(4), SOS1(5), SOS2(2), TRIP10(1), TSC1(1), TSC2(2) 25285499 332 101 266 83 64 127 5 106 28 2 0.0328 1.000 1.000 439 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF4(2), CACNA1C(3), CACNA1D(1), CACNA1F(2), CACNA1S(5), CAMK2D(1), CDC42(1), CGA(1), EGFR(11), FSHB(2), GNAQ(1), GNAS(4), GNRH2(1), GRB2(2), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MMP14(1), MMP2(6), NRAS(11), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(3), PLD2(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), RAF1(3), SOS1(5), SOS2(2) 20784766 234 99 188 61 53 101 6 47 26 1 0.0375 1.000 1.000 440 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), CAMK2D(1), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(21), DCT(5), DVL2(1), DVL3(2), EDNRB(6), EP300(14), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GNAI1(2), GNAQ(1), GNAS(4), GSK3B(1), KIT(22), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), MITF(5), NRAS(11), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), TCF7(3), TCF7L1(1), TCF7L2(13), TYR(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1) 17158129 275 99 213 72 49 120 6 73 27 0 0.0475 1.000 1.000 441 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 165 ADCY1(5), ADCY2(7), ADCY3(1), ADCY7(3), ADCY8(4), ADCY9(3), ADORA2A(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), ATP2B4(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CAMK2D(1), CAMK4(3), CCKAR(3), CCKBR(4), CD38(1), CHRM2(4), CHRM3(2), CHRM5(1), CHRNA7(1), CYSLTR2(2), EDNRA(1), EDNRB(6), EGFR(11), ERBB2(9), ERBB3(4), ERBB4(9), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAS(4), GRIN2A(7), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), HRH2(1), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDE1C(2), PDGFRA(8), PDGFRB(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTGER3(1), PTGFR(1), RYR1(12), RYR2(16), RYR3(2), SLC25A5(2), SLC8A1(2), SLC8A2(2), SLC8A3(4), SPHK1(1), TACR3(7), TRHR(2), TRPC1(2) 41573159 346 98 387 118 126 96 9 82 31 2 0.293 1.000 1.000 442 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(14), CACNA1A(1), CRHR1(2), GNA12(1), GNAI1(2), GNAQ(1), GNAS(4), GNAZ(2), GRIA1(3), GRIA2(6), GRIA3(4), GRID2(3), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(5), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(2), NPR2(2), NRAS(11), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), RYR1(12) 17997623 238 97 195 59 53 109 6 54 15 1 0.0192 1.000 1.000 443 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 191 ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(8), BCAR1(1), BIRC2(2), BIRC3(7), BRAF(14), CAPN2(2), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), CTNNB1(21), DOCK1(2), EGF(1), EGFR(11), ERBB2(9), FARP2(1), FIGF(2), FLNA(7), FLNB(4), FLNC(3), FLT1(9), FN1(6), FYN(2), GRB2(2), GRLF1(1), GSK3B(1), HGF(4), IGF1R(5), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), KDR(4), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), MAP2K1(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MET(7), MYL9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(5), PTEN(47), RAF1(3), RAP1A(1), RELN(12), RHOA(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TLN1(2), TLN2(4), TNC(3), TNN(3), TNR(3), VAV1(2), VAV2(2), VAV3(3), VCL(1), VEGFC(4), VTN(3), VWF(6), ZYX(3) 59405753 587 96 574 223 148 171 10 199 57 2 0.946 1.000 1.000 444 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 223 ADCYAP1R1(1), ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRA2B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(2), CCKAR(3), CCKBR(4), CGA(1), CHRM2(4), CHRM3(2), CHRM5(1), CNR1(3), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2(1), F2RL1(1), F2RL2(2), FPR1(3), FSHB(2), FSHR(3), GABBR1(4), GABBR2(8), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GABRB1(1), GABRB2(3), GABRB3(5), GABRE(2), GABRG1(4), GABRG2(5), GABRG3(1), GABRP(4), GABRQ(3), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(3), GPR83(1), GRIA1(3), GRIA2(6), GRIA3(4), GRIA4(10), GRID1(2), GRID2(3), GRIK2(6), GRIK3(5), GRIK4(1), GRIK5(1), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM6(3), GRM7(6), GRM8(2), GZMA(3), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LEPR(6), LTB4R(1), MAS1(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPBWR1(2), NPFFR2(1), NPY5R(2), NR3C1(3), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(3), P2RY14(2), P2RY2(2), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PRSS1(1), PTGDR(2), PTGER3(1), PTGFR(1), PTH2R(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(1), SSTR2(2), SSTR4(2), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(3), TAAR8(1), TACR3(7), TRHR(2), TRPV1(2), TSHB(1), TSHR(4), VIPR1(1) 35342127 383 91 380 134 143 119 7 81 32 1 0.181 1.000 1.000 445 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 105 ACTN1(4), ACTN2(4), ACTN4(1), ARHGAP5(8), BCAR1(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CXCR4(1), CYBB(2), GNAI1(2), GRLF1(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), ITK(5), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(6), MMP9(5), MSN(3), MYL9(3), NCF2(2), NCF4(1), NOX3(3), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), PTPN11(10), RAP1A(1), RAPGEF3(2), RHOA(1), RHOH(1), ROCK1(8), ROCK2(5), SIPA1(1), TXK(2), VAV1(2), VAV2(2), VAV3(3), VCAM1(3), VCL(1) 19986595 242 85 233 77 56 71 1 94 18 2 0.630 1.000 1.000 446 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), ATP1A4(3), ATP1B2(2), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1S(5), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(4), CHRM3(2), CHRM5(1), GJA1(4), GJB3(1), GJB4(1), GNAQ(1), GNAZ(2), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNB1(3), KCNJ5(1), MIB1(5), MYCBP(1), NME7(3), PKIA(2), PLCB3(1), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RYR1(12), RYR2(16), RYR3(2), SLC8A1(2), SLC8A3(4), USP5(1), YWHAH(2) 29231321 214 80 258 75 78 68 1 38 28 1 0.371 1.000 1.000 447 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN1(4), ACTN2(4), ACTN4(1), ACVR1B(3), ACVR1C(2), BAIAP2(1), CDC42(1), CDH1(12), CREBBP(13), CTNNA1(2), CTNNA2(5), CTNNB1(21), EGFR(11), EP300(14), ERBB2(9), FARP2(1), FER(3), FGFR1(2), FYN(2), IGF1R(5), INSR(1), IQGAP1(7), LMO7(2), MAP3K7(2), MAPK3(1), MET(7), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(2), PTPRF(2), PTPRJ(3), PTPRM(10), PVRL1(2), PVRL2(1), PVRL3(1), PVRL4(1), RHOA(1), SMAD2(7), SMAD3(5), SMAD4(25), SNAI1(1), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L1(1), TCF7L2(13), TGFBR1(3), TGFBR2(2), TJP1(4), VCL(1), WASF1(3), WASF3(3), WASL(2), YES1(1) 19960771 246 79 234 65 58 71 2 80 34 1 0.143 1.000 1.000 448 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 CHAD(1), COL11A1(9), COL11A2(2), COL17A1(3), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DES(1), DSC1(2), DSC2(1), DSC3(1), DSG1(4), DSG2(1), DSG4(5), FN1(6), GJA1(4), GJA10(5), GJA3(1), GJA8(3), GJA9(1), GJB3(1), GJB4(1), GJB7(1), GJC1(1), GJC3(1), GJD2(1), INA(1), ITGA6(2), ITGB4(2), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT17(1), KRT2(1), KRT20(1), KRT24(3), KRT27(1), KRT3(3), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT4(8), KRT5(1), KRT6A(1), KRT6C(1), KRT7(2), KRT73(4), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT81(1), KRT82(2), KRT83(1), KRT84(4), KRT85(3), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), LMNA(1), LMNB1(2), LMNB2(1), NES(2), PRPH(1), RELN(12), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VIM(2), VTN(3), VWF(6) 39636747 275 78 273 132 107 85 3 43 37 0 0.998 1.000 1.000 449 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CDS1(2), CDS2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), IMPA2(1), INPP1(1), INPP4B(3), INPP5D(2), INPPL1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), OCRL(5), PI4KA(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PRKCA(3), PRKCG(5), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1) 19949920 236 77 233 78 47 67 4 96 19 3 0.820 1.000 1.000 450 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ACTA1(2), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF1(1), ATF2(1), ATF4(2), ATP2A2(1), ATP2A3(2), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(2), DGKZ(1), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GJA1(4), GNAQ(1), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), GSTO1(1), GUCY1A3(8), IGFBP3(2), IL1B(1), IL6(2), ITPR1(2), ITPR2(8), ITPR3(5), MIB1(5), MYL4(1), MYLK2(1), NFKB1(3), NOS1(8), NOS3(2), OXTR(1), PDE4B(4), PDE4D(2), PKIA(2), PLCB3(1), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(12), RYR2(16), RYR3(2), SLC8A1(2), SP1(1), USP5(1), YWHAH(2) 26207793 205 77 232 62 71 71 2 32 28 1 0.115 1.000 1.000 451 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(3), ACVR1B(3), ACVRL1(1), BMPR2(3), BUB1(3), CDKL1(3), CDS1(2), CDS2(1), CLK1(2), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKG1(6), RAF1(3), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), TGFBR1(3), VRK1(1) 18404608 193 76 185 60 41 53 1 78 20 0 0.707 1.000 1.000 452 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 ALCAM(1), CADM1(3), CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD6(1), CD80(2), CD8A(1), CDH1(12), CDH15(1), CDH2(7), CDH3(2), CDH4(5), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(6), CTLA4(1), GLG1(2), HLA-A(3), HLA-B(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(8), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), ICAM2(1), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(4), ITGA9(4), ITGAL(3), ITGAM(1), ITGAV(4), ITGB1(1), ITGB2(2), ITGB7(3), ITGB8(3), L1CAM(3), MAG(2), NCAM1(2), NCAM2(8), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(4), NRXN1(5), NRXN2(3), NRXN3(2), PTPRC(9), PTPRF(2), PTPRM(10), PVR(1), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(2), SDC2(1), SDC3(2), SELE(2), SELP(2), SELPLG(3), SIGLEC1(2), SPN(2), VCAM1(3), VCAN(14) 23640540 230 74 228 73 66 72 4 45 39 4 0.398 1.000 1.000 453 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 77 ABL1(4), ACTN1(4), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(3), ARHGEF7(2), BCAR1(1), BRAF(14), CAV1(1), CDC42(1), CDKN2A(2), DOCK1(2), EPHB2(1), FYN(2), GRB2(2), GRLF1(1), ITGA10(4), ITGA2(1), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGB3BP(2), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PKLR(1), PLCG1(2), PLCG2(5), PTEN(47), RAF1(3), RALA(1), RHO(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1), TLN1(2), TLN2(4), ZYX(3) 19965070 258 73 251 100 45 75 6 106 26 0 0.983 1.000 1.000 454 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 154 ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(4), CHRM2(4), CHRM3(2), CHRM5(1), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2RL1(1), F2RL2(2), FPR1(3), FSHR(3), GALR1(1), GPR17(1), GPR174(2), GPR37(3), GPR4(1), GPR6(1), GPR63(3), GPR77(1), GPR83(1), GPR85(1), GPR87(1), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LTB4R(1), MAS1(1), MC3R(1), MC4R(1), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPY5R(2), NTSR2(1), OPN3(1), OPRK1(2), OPRL1(1), OPRM1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(2), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(3), P2RY12(1), P2RY14(2), P2RY2(2), P2RY6(1), PPYR1(3), PTGDR(2), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(2), SSTR4(2), SUCNR1(3), TRHR(2) 18913775 208 72 208 63 75 75 3 43 12 0 0.0161 1.000 1.000 455 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 144 AKT2(1), AKT3(1), CBL(7), CBLB(3), CREBBP(13), CSF3(1), CSF3R(1), EP300(14), GH1(1), GH2(2), GRB2(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL13RA2(2), IL19(1), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK2(7), JAK3(4), LEPR(6), LIFR(6), MPL(4), OSMR(2), PIAS2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIM1(1), PRL(1), PRLR(2), PTPN11(10), SOCS2(2), SOCS4(1), SOCS5(2), SOS1(5), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT1(2), STAT2(2), STAT4(3), STAT5A(2), STAT5B(1), TPO(7) 23975102 248 72 237 88 43 74 5 92 30 4 0.930 1.000 1.000 456 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 83 CD44(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DAG1(2), FN1(6), FNDC1(7), FNDC3A(2), GP5(1), GP6(2), HMMR(2), HSPG2(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), RELN(12), SDC1(2), SDC2(1), SDC3(2), SV2A(2), SV2B(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VTN(3), VWF(6) 35452440 239 71 250 107 83 73 6 46 31 0 0.974 1.000 1.000 457 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT2(1), AKT3(1), CASP8(1), CD40(1), CD80(2), CHUK(4), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(2), IL8(1), IRAK4(2), IRF3(2), LBP(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), RELA(1), STAT1(2), TBK1(1), TLR1(3), TLR2(5), TLR3(2), TLR4(3), TLR5(2), TLR6(2), TLR7(3), TLR8(9), TLR9(4), TNF(1), TRAF3(2) 14660027 187 70 178 53 38 55 4 70 17 3 0.331 1.000 1.000 458 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 240 ACVR1(3), ACVR1B(3), ACVR2A(2), ACVR2B(2), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL11(1), CCL18(1), CCL22(1), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR3(1), CXCR4(1), EDA(3), EDAR(2), EGF(1), EGFR(11), FAS(2), FLT1(9), FLT3(9), FLT4(2), GDF5(2), GH1(1), GH2(2), HGF(4), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(3), IL18RAP(2), IL19(1), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(4), INHBC(1), INHBE(1), KDR(4), KIT(22), LEPR(6), LIFR(6), LTBR(1), MET(7), MPL(4), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(2), TNFRSF13B(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(1), TNFSF13B(1), TNFSF14(1), TNFSF4(2), TNFSF8(2), TPO(7), VEGFC(4), XCL2(1), XCR1(1) 29424144 266 69 261 86 56 84 4 84 37 1 0.557 1.000 1.000 459 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTN2(4), ACTN4(1), DES(1), DMD(13), FAM48A(4), MYBPC1(3), MYBPC3(1), MYH3(7), MYH6(7), MYH7(4), MYH8(5), MYL1(1), MYL4(1), MYL9(3), MYOM1(8), NEB(8), TMOD1(1), TNNI3(1), TPM2(1), TPM3(1), TPM4(1), TTN(155), VIM(2) 17925243 235 69 246 59 62 93 1 63 15 1 0.0784 1.000 1.000 460 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB5(3), EBP(1), ERBB4(9), F2RL2(2), GRB2(2), GSK3B(1), IFI27(4), INPPL1(2), IRS1(4), IRS4(6), MET(7), NOLC1(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PPP1R13B(1), PREX1(5), PTEN(47), PTPN1(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SLC2A4(1), SOS1(5), SOS2(2), TSC1(1), TSC2(2), YWHAH(2) 12425943 198 66 186 74 28 60 2 87 21 0 0.961 1.000 1.000 461 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADSS(3), AK1(1), AK5(3), AK7(1), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), GDA(1), GMPR(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE10A(7), PDE11A(3), PDE1A(2), PDE1C(2), PDE3B(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE7A(1), PDE7B(2), PDE8B(3), PDE9A(1), PFAS(1), PKLR(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PPAT(3), PRIM2(1), PRPS1(1), PRPS1L1(1), PRUNE(1), RFC5(2), RRM1(1) 27551646 183 65 185 48 60 67 2 29 25 0 0.0586 1.000 1.000 462 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), DOCK1(2), FOS(1), GRB2(2), HGF(4), ITGB1(1), MAP2K1(2), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(6), MET(7), PAK1(1), PIK3CA(56), PIK3R1(9), PTEN(47), PTPN11(10), RAF1(3), RAP1A(1), RASA1(4), SOS1(5) 7478938 166 63 158 56 16 46 3 88 11 2 0.880 1.000 1.000 463 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF11(4), BTK(1), CDC42(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(5), LIMK1(1), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3CG(5), PIK3R1(9), PPP1R13B(1), PTEN(47), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2) 11359638 188 63 185 58 32 50 1 79 23 3 0.717 1.000 1.000 464 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 ATF1(1), BRAF(14), CREB3(1), CREB5(3), CREBBP(13), DAG1(2), EGR1(3), EGR2(2), FRS2(2), GNAQ(1), MAP1B(13), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), NTRK1(1), OPN1LW(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PTPN11(10), RPS6KA3(3), SHC1(1), TERF2IP(1) 7928297 162 63 149 51 27 43 6 68 16 2 0.536 1.000 1.000 465 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CPT1B(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(14), MAPK3(1), ME1(3), NCOA1(2), NCOR1(5), NCOR2(6), NR2F1(1), NRIP1(1), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PTGS2(1), RB1(16), RELA(1), SP1(1), SRA1(1), STAT5A(2), STAT5B(1), TNF(1) 10401284 152 62 137 45 33 26 3 68 20 2 0.510 1.000 1.000 466 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT2(1), AKT3(1), BRD4(1), CAP1(1), CBL(7), CDC42(1), CDKN2A(2), F2RL2(2), FLOT1(1), GRB2(2), GSK3B(1), INPPL1(2), IRS1(4), IRS4(6), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PPYR1(3), PTEN(47), PTPN1(1), RAF1(3), RPS6KA2(3), RPS6KA3(3), SERPINB6(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(2), YWHAH(2) 9592622 183 62 173 62 30 47 1 88 15 2 0.833 1.000 1.000 467 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), AKT3(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), ITPR1(2), ITPR2(8), ITPR3(5), PDK1(2), PIK3CA(56), PLCG2(5), PPP1R13B(1), PREX1(5), PTEN(47), PTPRC(9), RPS6KA2(3), RPS6KA3(3), SYK(3), TEC(2), VAV1(2) 8962103 160 60 157 57 22 49 1 74 13 1 0.929 1.000 1.000 468 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA2(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MINPP1(2), OCRL(5), PI4KA(5), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1) 11988992 163 59 152 61 17 50 4 81 11 0 0.976 1.000 1.000 469 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), FOS(1), GRB2(2), MAP2K1(2), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PAK2(1), PIK3CA(56), PIK3R1(9), PLA2G4A(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2) 7152162 120 58 111 33 23 29 2 53 11 2 0.369 1.000 1.000 470 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), FLT1(9), FLT4(2), HIF1A(2), KDR(4), NOS3(2), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), SHC1(1), VHL(22) 5533853 116 58 105 32 17 23 2 66 6 2 0.442 1.000 1.000 471 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(2), EIF4G1(2), EIF4G3(3), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PRKCA(3), PTEN(47) 4742134 131 57 121 48 13 34 2 71 9 2 0.945 1.000 1.000 472 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(1), EIF2S3(1), GSK3B(1), IGF1R(5), INPPL1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), RPS6(1) 3343747 124 57 114 44 7 35 1 71 8 2 0.946 1.000 1.000 473 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), AKT3(1), BTK(1), CDKN2A(2), GRB2(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(56), PPP1R13B(1), PTEN(47), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TEC(2), YWHAH(2) 5980212 135 57 125 52 12 40 1 75 7 0 0.971 1.000 1.000 474 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5) 7276040 105 56 96 30 14 28 1 54 8 0 0.659 1.000 1.000 475 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(2), EIF4B(1), EIF4G1(2), EIF4G3(3), FKBP1A(1), MKNK1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), RPS6(1), TSC1(1), TSC2(2) 4552652 128 56 118 46 12 35 2 69 8 2 0.926 1.000 1.000 476 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), CDKN1B(2), GRB2(2), ITGB1(1), MAPK3(1), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), SHC1(1), SOS1(5) 3178714 126 56 116 43 7 35 1 71 10 2 0.915 1.000 1.000 477 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT2(1), AKT3(1), BRAF(14), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PRKAA1(1), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), TSC1(1), TSC2(2), ULK1(2), VEGFC(4) 8399760 130 55 118 39 22 30 2 62 12 2 0.601 1.000 1.000 478 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(5), BAX(2), IGF1R(5), KIT(22), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), YWHAH(2) 3537259 111 54 101 36 16 23 1 61 8 2 0.778 1.000 1.000 479 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RB1(16), RELA(1), SP1(1) 3376975 98 54 88 33 13 19 2 54 8 2 0.804 1.000 1.000 480 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), AKT3(1), GRB2(2), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PTEN(47), RBL2(2), SHC1(1), SOS1(5) 3391843 119 54 109 44 7 35 1 70 6 0 0.963 1.000 1.000 481 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(1), GORASP1(2), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIE(1), PIK3CA(56), PIK3CD(1), PIK3R1(9), TRAF3(2), TRAF5(2) 4832772 105 54 96 31 18 24 2 48 11 2 0.547 1.000 1.000 482 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(5), INSR(1), MAP2K6(1), MAPK14(1), MEF2A(2), NFATC1(2), NFATC2(2), PIK3CA(56), PIK3R1(9), PPP3CA(2), PPP3CB(1), PPP3CC(2), YWHAH(2) 5371698 93 53 85 31 13 23 1 46 8 2 0.767 1.000 1.000 483 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT3(1), BCAR1(1), CAPN2(2), CAPN3(1), CAPN5(3), CAPN6(2), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(2), GIT2(1), GRB2(2), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), RHO(1), ROCK1(8), ROCK2(5), SDCCAG8(2), SEPP1(1), SHC1(1), SORBS1(4), SOS1(5), TLN1(2), TNS1(5), VAV2(2), VAV3(3), VCL(1), ZYX(3) 21777796 142 52 146 52 36 49 7 27 23 0 0.755 1.000 1.000 484 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(1), BRAF(14), CHUK(4), DAXX(4), FOS(1), GRB2(2), IKBKB(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK6(1), MAPK8(6), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(3), RELA(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KB2(2), SHC1(1), SP1(1), STAT1(2), TGFB2(4), TGFBR1(3) 15253500 130 52 130 38 23 36 4 49 18 0 0.416 1.000 1.000 485 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(56), PIK3R1(9), RAF1(3), RB1(16), RELA(1) 3416602 93 52 83 32 15 15 1 51 9 2 0.832 1.000 1.000 486 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(13), ASH2L(1), CTCFL(1), DOT1L(1), EHMT1(2), EHMT2(3), EZH1(1), EZH2(2), FBXO11(1), HCFC1(2), HSF4(1), JMJD4(1), JMJD6(1), KDM6A(1), MEN1(6), MLL(8), MLL2(8), MLL3(13), MLL4(5), MLL5(6), NSD1(4), OGT(2), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(10), PRMT7(1), PRMT8(3), SATB1(1), SETD1A(1), SETD2(8), SETD7(2), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(4), SUV39H2(1), SUV420H1(4), SUZ12(1), WHSC1(3) 19090018 138 51 136 34 37 38 1 37 24 1 0.254 1.000 1.000 487 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 103 A4GNT(2), ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), CHST1(1), CHST11(2), CHST12(2), CHST2(2), CHST3(1), CHST4(2), DPAGT1(2), EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), NDST1(1), NDST2(1), NDST3(4), OGT(2), RPN2(1), ST3GAL1(1), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(5), XYLT1(2) 17682677 118 51 117 47 38 34 2 35 9 0 0.869 1.000 1.000 488 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(7), CD28(1), CD3D(1), CSK(2), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(1), FBXW7(37), GRAP2(4), GRB2(2), ITK(5), ITPKB(1), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), NFKBIE(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLCG1(2), PTPRC(9), RAF1(3), RASGRP1(1), RASGRP2(2), RASGRP3(1), SOS1(5), SOS2(2), VAV1(2) 8931815 114 51 115 32 34 32 1 32 14 1 0.360 1.000 1.000 489 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 CABIN1(2), CAMK4(3), CD3G(1), CD69(2), CNR1(3), CREBBP(13), CTLA4(1), EGR2(2), EP300(14), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(1), GSK3B(1), IFNA1(1), IL10(1), IL1B(1), IL2(1), IL2RA(3), IL6(2), IL8(1), ITK(5), MAP2K7(2), MAPK14(1), MAPK8(6), MAPK9(3), MEF2A(2), MYF5(2), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIE(1), NPPB(1), NUP214(4), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPRC(9), RELA(1), SP1(1), SP3(3), TNF(1), TRPV6(6), VAV1(2), VAV2(2), VAV3(3) 14442763 127 50 130 39 42 34 3 30 18 0 0.313 1.000 1.000 490 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(3), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD22(2), CD33(1), CD38(1), CD3D(1), CD3G(1), CD44(1), CD5(2), CD55(1), CD7(2), CD8A(1), CR1(1), CR2(2), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), DNTT(2), FLT3(9), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(3), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGAM(1), ITGB3(4), KIT(22), MME(4), TFRC(2), THPO(1), TNF(1), TPO(7) 13368362 120 50 124 35 33 38 3 34 12 0 0.287 1.000 1.000 491 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM17(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(4), CSK(2), EGFR(11), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK8(6), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG1(2), PLCG2(5), PTPN11(10), PTPRZ1(6), RELA(1), TCIRG1(1), TJP1(4) 11942493 111 50 111 33 25 33 2 41 9 1 0.441 1.000 1.000 492 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADSS(3), AK1(1), AK5(3), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), ATP5A1(3), ATP5C1(3), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), GDA(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NPR1(2), NPR2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE1A(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE6C(2), PDE7B(2), PDE9A(1), PFAS(1), PKLR(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), PPAT(3), PRPS1(1), PRPS1L1(1), PRUNE(1), RRM1(1) 21182558 138 50 139 42 45 45 2 27 19 0 0.338 1.000 1.000 493 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC4(4), ANAPC5(1), BTRC(4), CDC16(1), CDC27(5), CUL1(1), CUL2(1), FBXW11(1), FBXW7(37), FZR1(1), RBX1(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(2), UBE2C(1), UBE2D3(1), UBE2E2(1), VHL(22), WWP1(3), WWP2(1) 7007949 93 49 88 34 20 23 1 33 15 1 0.888 1.000 1.000 494 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(1), CD3G(1), CD80(2), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(5), LCK(1), PIK3CA(56), PIK3R1(9), PTPN11(10) 2160321 92 48 84 27 12 23 1 48 6 2 0.694 1.000 1.000 495 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 CAT(1), GH1(1), IGF1R(5), PIK3CA(56), PIK3R1(9), SHC1(1) 2200607 73 47 64 25 6 16 1 45 3 2 0.846 1.000 1.000 496 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(56), PIK3R1(9), PLCB1(1), PLCG1(2), PRKCA(3), VAV1(2) 2250716 73 47 64 22 8 18 1 41 3 2 0.754 1.000 1.000 497 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(5), ABCA12(16), ABCA13(2), ABCA2(1), ABCA3(2), ABCA4(4), ABCA5(3), ABCA6(7), ABCA7(1), ABCA8(9), ABCA9(7), ABCB1(6), ABCB10(1), ABCB4(5), ABCB5(5), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(2), ABCC1(5), ABCC10(2), ABCC11(3), ABCC12(5), ABCC2(5), ABCC3(1), ABCC5(2), ABCC6(4), ABCC8(4), ABCC9(4), ABCD2(3), ABCG1(1), ABCG2(5), CFTR(5), TAP1(2), TAP2(1) 18979757 137 44 154 45 34 51 3 29 19 1 0.376 1.000 1.000 498 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(3), BDKRB1(1), BDKRB2(2), C1S(3), C2(4), C3(2), C3AR1(2), C4B(2), C4BPA(6), C5(5), C5AR1(1), C6(3), C7(1), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(7), CPB2(1), CR1(1), CR2(2), F13A1(3), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), KNG1(1), MASP1(4), PLAT(1), PLAU(1), PLAUR(2), PLG(4), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(6) 15592644 121 44 128 32 32 46 2 30 11 0 0.145 1.000 1.000 499 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), ENPP3(2), EP400(4), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), IFIH1(2), MOV10L1(7), PGM1(2), PGM3(2), PYGL(2), PYGM(2), RAD54B(2), RUVBL2(2), SETX(10), SI(4), SKIV2L2(2), SMARCA2(3), SMARCA5(5), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UXS1(1) 20952945 125 43 124 35 31 38 1 31 24 0 0.327 1.000 1.000 500 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 53 BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BTRC(4), CSNK1A1L(1), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(7), GSK3B(1), HHIP(1), LRP2(16), PRKACA(1), PRKACB(1), PRKACG(1), PTCH1(13), PTCH2(2), RAB23(1), SMO(2), STK36(4), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1) 9338760 84 43 84 34 23 29 0 20 12 0 0.835 1.000 1.000 501 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(1), CCKBR(4), CCR3(2), CELSR1(1), CELSR2(2), CELSR3(1), CHRM2(4), CHRM3(2), CXCR3(1), EDNRA(1), EMR2(4), EMR3(1), FSHR(3), GPR116(5), GPR133(1), GPR17(1), GPR18(2), GPR56(1), GPR61(3), GPR77(1), GPR84(3), GRM1(5), LGR6(1), LPHN2(4), LPHN3(4), OR2M4(2), PTGFR(1), SMO(2), SSTR2(2), TAAR5(2), TSHR(4) 9904822 71 41 75 34 23 19 3 21 5 0 0.945 1.000 1.000 502 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), CRADD(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NUMA1(5), PAK2(1), PRKDC(5), PSEN1(1), RASA1(4), RB1(16), RELA(1), SPTAN1(5), TNF(1), TRAF1(2) 11009050 90 41 91 28 28 21 1 28 12 0 0.625 1.000 1.000 503 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 67 ACACB(3), ACSL3(1), ACSL5(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CAMKK2(1), CHUK(4), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(4), IRS4(6), JAK1(2), JAK2(7), JAK3(4), LEPR(6), MAPK10(4), MAPK8(6), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIE(1), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(10), RELA(1), RXRB(1), RXRG(1), SLC2A1(2), SLC2A4(1), TNF(1) 13465728 107 40 107 37 26 35 2 31 11 2 0.684 1.000 1.000 504 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(4), DAXX(4), EGF(1), EGFR(11), ETS1(4), ETS2(1), FOS(1), HOXA7(1), IKBKB(2), MAP2K1(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), NFKB1(3), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), RAF1(3), RELA(1), SP1(1), TNF(1) 8145568 77 40 76 28 24 17 2 29 5 0 0.706 1.000 1.000 505 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 ADAM17(2), CREBBP(13), CTBP2(1), DLL1(4), DLL3(1), DLL4(2), DTX2(2), DTX3(1), DTX3L(1), DVL2(1), DVL3(2), EP300(14), JAG1(1), LFNG(1), MAML1(2), MAML2(1), NCOR2(6), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PSEN1(1), PTCRA(1), RBPJ(5), SNW1(1) 9674111 79 39 75 30 21 20 3 17 18 0 0.818 1.000 1.000 506 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), AKT3(1), BRAF(14), DAG1(2), DRD2(2), EGFR(11), EPHB2(1), GRB2(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), PI3(1), PIK3CB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), RAF1(3), RGS20(1), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1) 9550400 73 38 77 24 20 15 1 31 5 1 0.640 1.000 1.000 507 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(1), FBXW7(37), RB1(16) 1497171 54 37 48 23 13 7 1 20 12 1 0.938 1.000 1.000 508 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 62 ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CHPT1(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), ESCO1(6), ESCO2(5), ETNK2(1), GNPAT(2), GPAM(1), GPD1L(1), GPD2(1), MYST3(6), MYST4(8), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3), PTDSS1(3), SH3GLB1(1) 10799817 84 37 85 29 30 25 1 20 8 0 0.605 1.000 1.000 509 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(1), ADCY8(4), CACNA1A(1), CACNA1B(4), GNAS(4), GNG3(1), ITPR3(5), KCNB1(3), PDE1A(2), PLCB2(1), PRKACA(1), PRKACB(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(4), TAS2R14(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R5(2), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2) 8584233 55 34 66 30 20 10 2 15 8 0 0.989 1.000 1.000 510 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ACAT2(1), ACMSD(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), KMO(3), KYNU(1), MAOA(2), MAOB(3), TDO2(3), TPH1(2), WARS(1), WARS2(1) 9329079 67 34 66 28 16 24 1 17 9 0 0.919 1.000 1.000 511 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(1), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HSD17B10(1), INMT(1), KMO(3), KYNU(1), LNX1(5), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), NFX1(3), OGDH(1), OGDHL(4), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), TDO2(3), TPH1(2), TPH2(3), WARS(1), WARS2(1) 10203360 72 32 71 27 16 29 1 14 12 0 0.769 1.000 1.000 512 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP3(1), CASP6(1), CASP8(1), CFLAR(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), PTPN13(3), RB1(16), SPTAN1(5) 6424618 60 31 72 18 13 14 1 22 10 0 0.648 1.000 1.000 513 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(2), CAMK2D(1), CDK5(1), F2(1), FYN(2), GNAI1(2), GNGT1(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(6), MAPT(1), MYLK(4), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), STAT1(2), STAT5A(2) 7164918 55 30 55 22 13 16 1 23 1 1 0.881 1.000 1.000 514 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDH7A1(2), AOC3(1), ASPA(2), HAL(1), HARS2(2), HDC(6), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3) 6522554 47 30 44 18 13 14 2 7 11 0 0.775 1.000 1.000 515 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), DAK(1), DGAT2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(7), LIPC(1), LIPF(2), MGLL(1), PNLIP(4), PNLIPRP2(1) 9610237 64 30 66 28 20 19 2 15 8 0 0.878 1.000 1.000 516 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 FOS(1), GRB2(2), IL6(2), IL6R(1), IL6ST(1), JAK1(2), JAK2(7), JAK3(4), MAP2K1(2), MAPK3(1), PTPN11(10), RAF1(3), SHC1(1), SOS1(5) 4017938 42 30 42 15 7 10 0 20 3 2 0.847 1.000 1.000 517 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 CASP3(1), CASP8(1), CRADD(1), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), RB1(16), SPTAN1(5), TNF(1) 6147349 57 30 60 22 16 12 1 19 9 0 0.879 1.000 1.000 518 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CREBBP(13), EP300(14), ERCC3(1), ESR1(1), GRIP1(3), GTF2A1(1), GTF2F1(2), HDAC5(1), HDAC6(2), NCOR2(6), NR0B1(1), NRIP1(1), POLR2A(2), SRA1(1) 7620193 52 29 48 19 11 15 3 14 9 0 0.767 1.000 1.000 519 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CLC(1), CPT1B(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), GNPAT(2), GPD2(1), LGALS13(1), PAFAH2(1), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G4A(3), PLA2G6(2), PLCB2(1), PLCG1(2), PLCG2(5) 7982003 51 29 53 29 26 9 0 11 5 0 0.988 1.000 1.000 520 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CPT1B(1), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PISD(3), PLCB2(1), PLCG1(2), PLCG2(5), PSPH(1), SARDH(2), SARS(1), SHMT1(1), TARS(3) 6968155 51 28 51 21 23 13 0 10 5 0 0.793 1.000 1.000 521 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(11), GNAS(4), GNGT1(1), GRB2(2), IGF1R(5), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(8), PTPRR(5), RAF1(3), RPS6KA5(3), SHC1(1), SOS1(5) 5569512 57 27 57 20 10 14 3 26 3 1 0.776 1.000 1.000 522 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(3), CSTF3(2), DDIT3(1), DDX1(1), DDX20(1), DHX15(2), DHX16(2), DHX38(2), DHX8(2), DHX9(1), DICER1(2), LSM2(1), METTL3(1), NCBP1(4), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF18(1), PRPF4(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(3), RNMT(1), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(1), SRPK2(3), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(2), XRN2(2) 17832165 74 27 75 21 23 25 1 15 10 0 0.582 1.000 1.000 523 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(4), AGT(2), AGTR2(2), EDNRA(1), EDNRB(6), EGF(1), EGFR(11), FOS(1), NFKB1(3), PLCG1(2), PRKCA(3), RELA(1) 3534464 37 26 36 16 14 9 0 12 2 0 0.855 1.000 1.000 524 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AGPAT1(1), AGPAT4(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), LCT(7), LIPC(1), LIPF(2), PNLIP(4), PNLIPRP2(1) 7826478 49 26 51 24 15 12 2 13 7 0 0.932 1.000 1.000 525 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PIPOX(1), PISD(3), PSAT1(1), PSPH(1), RDH11(1), RDH12(1), SARDH(2), SARS(1), SHMT1(1), TARS(3), TARS2(1) 7207978 47 25 47 19 21 15 0 7 4 0 0.738 1.000 1.000 526 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(6), ACACB(3), ACAT2(1), ACOT12(3), ACSS1(1), ACSS2(1), ACYP1(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 7956504 57 25 57 20 14 20 2 15 6 0 0.608 1.000 1.000 527 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ACADS(1), ACAT2(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BDH1(1), DDHD1(12), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), HMGCS2(1), HSD17B10(1), ILVBL(1), PDHA1(1), PDHA2(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1) 6978773 49 25 39 21 13 12 2 6 16 0 0.958 1.000 1.000 528 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(4), BAX(2), BCL2A1(3), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CD40(1), CRADD(1), DAXX(4), DFFA(2), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(3), NTRK1(1), PTPN13(3), TNF(1), TRAF1(2), TRAF3(2) 7052170 43 24 50 17 7 11 0 17 8 0 0.899 1.000 1.000 529 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(6), ACAT2(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 6186345 47 24 47 21 14 14 2 12 5 0 0.881 1.000 1.000 530 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(2), FPR1(3), GNA15(1), GNGT1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NCF2(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), RELA(1) 6240943 46 23 47 16 17 13 1 9 6 0 0.595 1.000 1.000 531 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GANAB(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2) 5168450 33 23 33 13 16 9 0 7 1 0 0.632 1.000 1.000 532 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), AOC3(1), ASPA(2), HAL(1), HDC(6), MAOA(2), MAOB(3), PRPS1(1) 4183750 31 23 28 15 6 9 2 5 9 0 0.958 1.000 1.000 533 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1) 7509822 43 23 42 15 12 14 1 7 9 0 0.716 1.000 1.000 534 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), PRDX1(1), PRDX6(1), TAT(2), TPO(7) 3662048 35 23 32 13 8 11 2 3 11 0 0.780 1.000 1.000 535 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 ATF1(1), CDC42(1), CREB3(1), CREB5(3), DUSP1(1), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K10(1), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), NFKB1(3) 5509015 38 23 38 15 10 14 2 8 4 0 0.779 1.000 1.000 536 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), UPB1(2) 4986301 34 22 33 18 7 9 2 9 7 0 0.961 1.000 1.000 537 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GOT1(1), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6B(1), LDHB(3), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PKLR(1) 6980960 46 22 46 22 20 14 0 8 4 0 0.837 1.000 1.000 538 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(4), GPRC5B(1), GPRC5C(1), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM7(6), GRM8(2) 3319060 33 22 33 15 12 11 1 6 3 0 0.715 1.000 1.000 539 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2), RDH11(1), RDH12(1), UGP2(2) 6091803 37 22 37 13 16 12 0 8 1 0 0.492 1.000 1.000 540 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), DCI(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HADHB(1), HSD17B10(1) 8270032 48 22 46 21 10 16 2 11 9 0 0.891 1.000 1.000 541 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX15(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP4A11(1), CYP4F3(1), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2) 6555387 37 22 37 13 16 5 2 6 7 1 0.691 1.000 1.000 542 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), AOX1(3), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HMGCL(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1) 6229713 40 22 39 15 11 13 1 7 8 0 0.787 1.000 1.000 543 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(2), F2(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), LPA(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2), VWF(6) 6046167 42 21 42 20 13 15 1 9 4 0 0.927 1.000 1.000 544 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HIBCH(1), UPB1(2) 4594991 34 21 33 17 6 10 2 9 7 0 0.943 1.000 1.000 545 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), CHRM2(4), CHRM3(2), CHRM5(1), DRD2(2), DRD3(1), DRD5(4), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1) 4011219 43 21 43 17 16 16 1 6 4 0 0.433 1.000 1.000 546 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(7), EGF(1), EGFR(11), GRB2(2), MAP2K1(2), MAPK3(1), PTPRB(2), RAF1(3), RASA1(4), SHC1(1), SOS1(5), SPRY1(1) 3933965 40 21 40 14 9 8 0 21 2 0 0.735 1.000 1.000 547 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 ABO(2), B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2), ST3GAL1(1), ST3GAL6(4), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3) 7658470 54 20 55 22 16 19 1 10 8 0 0.855 1.000 1.000 548 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), F2(1), F5(7), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), PROS1(3), SERPING1(2) 7822247 44 20 44 17 11 17 1 10 5 0 0.775 1.000 1.000 549 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN2(2), CXCR3(1), EGF(1), EGFR(11), ITGB1(1), MAPK3(1), MYLK(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), TLN1(2) 5566718 35 20 35 17 9 9 0 13 4 0 0.949 1.000 1.000 550 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP4K2(1), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TANK(3), TNF(1) 3935858 35 19 35 12 10 12 2 10 1 0 0.620 1.000 1.000 551 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), RB1(16), RBL1(3) 2691378 26 18 25 14 6 2 0 12 6 0 0.961 1.000 1.000 552 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), EGFR(11), ERBB3(4), NRG1(7) 1818440 23 18 23 10 5 4 0 12 2 0 0.919 1.000 1.000 553 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), PON1(1) 4786977 33 18 33 11 13 6 0 10 3 1 0.580 1.000 1.000 554 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), CLYBL(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), OGDH(1), OGDHL(4), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1) 5075671 30 18 30 14 7 10 0 10 3 0 0.913 1.000 1.000 555 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), CYP7A1(1), HADHB(1), RDH11(1), RDH12(1), SLC27A5(2) 5301152 31 18 30 13 6 10 1 8 6 0 0.829 1.000 1.000 556 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(2), CUL1(1), NEDD8(1), RB1(16), RBX1(1) 1501449 21 18 20 13 5 1 0 9 6 0 0.983 1.000 1.000 557 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), IL6R(1), JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2) 2571607 24 18 24 10 11 3 0 6 2 2 0.865 1.000 1.000 558 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CFLAR(1), MAP2K4(4), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIE(1), RALBP1(2), TNF(1), TNFAIP3(3) 4296206 32 18 30 12 10 10 1 7 4 0 0.721 1.000 1.000 559 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(4), EGR2(2), GNAQ(1), MAP3K1(3), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1) 4523469 35 18 35 13 16 9 0 6 4 0 0.657 1.000 1.000 560 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1) 3477598 24 17 24 12 5 9 0 7 3 0 0.935 1.000 1.000 561 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(1), DDX20(1), ETS1(4), ETS2(1), ETV3(1), FOS(1), HDAC5(1), NCOR2(6), RBL1(3), RBL2(2), SIN3A(8), SIN3B(1) 4222434 31 17 29 11 9 9 0 9 4 0 0.719 1.000 1.000 562 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1) 6723086 30 17 30 14 7 10 2 6 5 0 0.915 1.000 1.000 563 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(2), DHDDS(2), DPAGT1(2), FUT8(1), GANAB(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), RPN2(1), STT3B(2) 6822655 36 17 36 17 10 10 1 10 5 0 0.920 1.000 1.000 564 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(2), FUCA1(2), FUCA2(1), GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1), NAGLU(1), SPAM1(4) 5375280 35 17 34 15 13 9 0 8 5 0 0.819 1.000 1.000 565 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(3), DLD(1), DLST(1), FH(1), IDH2(1), IDH3A(3), OGDH(1), PC(4), PDHA1(1), PDHA2(3), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(2), SUCLA2(3), SUCLG1(1) 4826227 32 17 32 16 9 11 0 9 3 0 0.944 1.000 1.000 566 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), EGFR(11), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(1) 2773802 25 16 23 12 5 6 0 11 3 0 0.970 1.000 1.000 567 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(10), DPYS(2), ENPP3(2), ILVBL(1), PANK3(1), PPCS(2), UPB1(2), VNN1(2) 2819921 23 16 23 12 4 10 1 4 4 0 0.951 1.000 1.000 568 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(4), FARS2(2), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(3), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1) 9102115 39 16 39 15 8 16 1 9 5 0 0.864 1.000 1.000 569 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), CYP7A1(1), HADHB(1) 3931589 22 15 21 12 3 6 1 7 5 0 0.957 1.000 1.000 570 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAX(2), CASP8(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFKB1(3), NSMAF(3), RAF1(3), RELA(1), SMPD1(1) 3442960 30 15 30 11 8 11 1 6 4 0 0.736 1.000 1.000 571 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DARS2(1), DLAT(3), DLD(1), GAD1(2), GOT1(1), GPT(1), NARS(1), NARS2(3), PC(4), PDHA1(1), PDHA2(3) 6299155 36 15 36 22 15 11 1 6 3 0 0.988 1.000 1.000 572 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(3), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(3), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKG1(6), PRKG2(2) 5325391 32 15 32 16 8 14 0 7 3 0 0.908 1.000 1.000 573 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CUL1(1), RB1(16) 1535334 19 15 18 14 3 1 0 10 5 0 0.995 1.000 1.000 574 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), PDHA1(1), PDHA2(3) 4452904 23 14 22 16 7 6 2 5 3 0 0.990 1.000 1.000 575 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1) 5652219 27 14 27 10 7 8 1 6 5 0 0.766 1.000 1.000 576 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3) 3994212 27 14 27 11 13 8 1 3 2 0 0.724 1.000 1.000 577 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), SLC23A1(1), SLC23A2(1), SLC2A1(2), SLC2A3(1) 4470623 19 14 19 12 7 7 0 2 3 0 0.956 1.000 1.000 578 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR1(2), AGTR2(2), COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), REN(2) 4548161 25 13 25 13 7 12 0 3 3 0 0.941 1.000 1.000 579 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), NAGLU(1), SPAM1(4) 3306781 25 13 24 10 9 8 0 6 2 0 0.726 1.000 1.000 580 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(7), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SMPD1(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGT8(2) 5317967 24 13 24 14 10 5 0 6 2 1 0.947 1.000 1.000 581 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), BST1(1), CD38(1), ENPP3(2), NADK(3), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1) 3774751 23 13 23 10 8 5 0 4 6 0 0.869 1.000 1.000 582 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(10), DPYS(2), ENPP3(2), PANK3(1), PPCS(2), UPB1(2) 2239649 20 13 20 10 4 7 1 4 4 0 0.930 1.000 1.000 583 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TANK(3), TNFAIP3(3), TRAF1(2), TRAF3(2) 3802175 24 13 24 12 8 8 0 7 1 0 0.906 1.000 1.000 584 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), CAD(3), CRAT(1), DARS(1), GAD1(2), GOT1(1), GPT(1), NARS(1), PC(4) 4326302 23 12 23 15 9 8 1 3 2 0 0.980 1.000 1.000 585 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TNFAIP3(3), TRAF3(2) 3123517 19 12 19 10 4 8 0 6 1 0 0.946 1.000 1.000 586 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PGK2(1), PKLR(1), TKT(1), TKTL1(1), TKTL2(3) 3379409 16 12 16 15 9 3 1 2 1 0 0.994 1.000 1.000 587 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXA(1), HEXB(2), LCT(7), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3) 2799392 20 11 20 11 8 6 0 5 1 0 0.903 1.000 1.000 588 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(1), CHUK(4), IKBKB(2), IL2(1), MAP3K1(3), MAP3K5(2), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF9(1) 3296986 25 10 25 10 5 12 1 7 0 0 0.816 1.000 1.000 589 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), MAP2K1(2), MAPK3(1), NFKB1(3), PLCB1(1), PRKCA(3), RAF1(3), RELA(1), TNF(1) 2578201 19 10 19 10 9 3 0 5 2 0 0.871 1.000 1.000 590 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), IKBKB(2), IL1R1(1), MAP3K1(3), MAP3K7(2), MYD88(1), NFKB1(3), RELA(1), TLR4(3), TNF(1), TNFAIP3(3) 3965191 24 10 24 10 6 8 0 9 1 0 0.831 1.000 1.000 591 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 BTK(1), EEA1(4), GSK3B(1), PFKM(3), PFKP(1), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), VAV2(2) 4056732 18 10 18 12 5 9 0 3 1 0 0.972 1.000 1.000 592 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(1), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(1) 1117529 11 9 11 7 4 3 0 4 0 0 0.914 1.000 1.000 593 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 GAL3ST1(2), LCT(7), SMPD1(1), SPTLC1(1) 3716848 11 9 11 10 5 2 0 3 1 0 0.989 1.000 1.000 594 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PKLR(1), TKT(1) 3007264 11 8 11 12 8 1 0 1 1 0 0.995 1.000 1.000 595 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(1), OGDH(1), SDHA(2), SUCLA2(3) 1619800 8 8 8 6 0 5 0 3 0 0 0.979 1.000 1.000 596 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), HIF1A(2), JAK2(7), NFKB1(3), RELA(1) 2135638 14 7 14 10 5 1 0 5 2 1 0.989 1.000 1.000 597 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT3(1), CHST11(2), CHST12(2), CHST3(1), DSE(1), UST(2), XYLT1(2) 2070476 11 7 11 9 6 2 0 3 0 0 0.975 1.000 1.000 598 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 EBP(1), FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 3173163 12 6 13 8 6 5 0 1 0 0 0.938 1.000 1.000 599 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), ILVBL(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3) 2843530 8 6 8 7 3 2 0 3 0 0 0.982 1.000 1.000 600 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ME1(3), PC(4), PDHA1(1) 1480805 8 6 8 5 6 2 0 0 0 0 0.861 1.000 1.000 601 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), PDE1A(2), PDE1B(1), PLCB1(1), PLCB2(1), PRL(1), TRH(1) 1881264 8 6 8 5 1 5 0 2 0 0 0.926 1.000 1.000 602 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2B5(1), EIF2S3(1), GSK3B(1) 1959086 6 5 6 3 0 3 0 3 0 0 0.876 1.000 1.000 603 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), IL8(1), NFKB1(3), RELA(1), TNF(1) 1720608 8 5 8 6 4 1 1 2 0 0 0.953 1.000 1.000 604 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF11A(1) 1830014 14 5 14 8 6 5 1 2 0 0 0.918 1.000 1.000 605 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3) 1742691 7 5 7 4 3 1 0 3 0 0 0.871 1.000 1.000 606 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), HMGCL(1), HMGCS2(1) 1276821 4 4 4 3 3 1 0 0 0 0 0.899 1.000 1.000 607 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1), CES1(1), ESD(1) 1005707 3 3 3 6 0 2 0 1 0 0 0.998 1.000 1.000 608 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1), TNF(1) 875299 3 3 3 4 2 0 0 1 0 0 0.990 1.000 1.000 609 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 GPI(1), PKLR(1) 1459705 2 2 2 4 1 0 0 1 0 0 0.991 1.000 1.000 610 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(2) 753381 2 2 2 3 0 2 0 0 0 0 0.990 1.000 1.000 611 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(3) 1063548 4 2 4 3 1 1 0 2 0 0 0.951 1.000 1.000 612 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(1) 602223 2 2 2 2 1 1 0 0 0 0 0.943 1.000 1.000 613 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), OAT(1) 889382 2 1 2 2 1 0 0 1 0 0 0.952 1.000 1.000 614 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1), IL2(1) 521899 2 1 2 2 0 2 0 0 0 0 0.969 1.000 1.000 615 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CHEK1(1) 1129050 1 1 1 3 0 0 0 1 0 0 0.997 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 92179 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000