Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.075 0.202 -9999.0 0.0 -0.628 6.0 6.0 IHH -0.158 0.328 -9999.0 0.0 -0.806 52.0 52.0 SHH Np/Cholesterol/GAS1 -0.079 0.177 -9999.0 0.0 -0.485 41.0 41.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.079 0.176 0.481 41.0 -9999.0 0.0 41.0 SMO/beta Arrestin2 -0.126 0.209 -9999.0 0.0 -0.516 51.0 51.0 SMO -0.135 0.222 -9999.0 0.0 -0.546 52.0 52.0 AKT1 -0.056 0.092 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.082 -9999.0 0.0 -0.457 7.0 7.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.109 0.234 -9999.0 0.0 -0.537 52.0 52.0 STIL -0.176 0.222 -9999.0 0.0 -0.522 58.0 58.0 DHH N/PTCH2 -0.043 0.142 -9999.0 0.0 -0.621 13.0 13.0 DHH N/PTCH1 -0.124 0.203 -9999.0 0.0 -0.466 59.0 59.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.042 0.171 -9999.0 0.0 -0.677 16.0 16.0 PTHLH -0.096 0.267 -9999.0 0.0 -1.155 6.0 6.0 determination of left/right symmetry -0.109 0.234 -9999.0 0.0 -0.537 52.0 52.0 PIK3R1 -0.004 0.053 -9999.0 0.0 -0.559 2.0 2.0 skeletal system development -0.095 0.263 -9999.0 0.0 -1.131 6.0 6.0 IHH N/Hhip -0.243 0.315 -9999.0 0.0 -0.61 100.0 100.0 DHH N/Hhip -0.158 0.268 -9999.0 0.0 -0.634 59.0 59.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.109 0.234 -9999.0 0.0 -0.537 52.0 52.0 pancreas development -0.17 0.312 -9999.0 0.0 -0.684 64.0 64.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.04 -9999.0 0.0 -0.609 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.057 -9999.0 0.0 -0.479 3.0 3.0 somite specification -0.109 0.234 -9999.0 0.0 -0.537 52.0 52.0 SHH Np/Cholesterol/PTCH1 -0.156 0.219 -9999.0 0.0 -0.525 42.0 42.0 SHH Np/Cholesterol/PTCH2 -0.085 0.177 -9999.0 0.0 -0.485 41.0 41.0 SHH Np/Cholesterol/Megalin -0.304 0.297 -9999.0 0.0 -0.552 142.0 142.0 SHH -0.087 0.225 -9999.0 0.0 -0.61 40.0 40.0 catabolic process -0.087 0.209 -9999.0 0.0 -0.478 51.0 51.0 SMO/Vitamin D3 -0.164 0.233 -9999.0 0.0 -0.52 51.0 51.0 SHH Np/Cholesterol/Hhip -0.177 0.259 -9999.0 0.0 -0.541 80.0 80.0 LRP2 -0.373 0.397 -9999.0 0.0 -0.796 121.0 121.0 receptor-mediated endocytosis -0.296 0.276 -9999.0 0.0 -0.754 51.0 51.0 SHH Np/Cholesterol/BOC -0.083 0.18 -9999.0 0.0 -0.488 42.0 42.0 SHH Np/Cholesterol/CDO -0.081 0.177 -9999.0 0.0 -0.485 41.0 41.0 mesenchymal cell differentiation 0.176 0.257 0.537 80.0 -9999.0 0.0 80.0 mol:Vitamin D3 -0.133 0.236 -9999.0 0.0 -0.454 79.0 79.0 IHH N/PTCH2 -0.121 0.22 -9999.0 0.0 -0.509 59.0 59.0 CDON -0.008 0.063 -9999.0 0.0 -0.416 5.0 5.0 IHH N/PTCH1 -0.106 0.201 -9999.0 0.0 -0.485 51.0 51.0 Megalin/LRPAP1 -0.286 0.304 -9999.0 0.0 -0.609 121.0 121.0 PTCH2 -0.018 0.083 -9999.0 0.0 -0.357 13.0 13.0 SHH Np/Cholesterol -0.077 0.178 -9999.0 0.0 -0.492 40.0 40.0 PTCH1 -0.087 0.21 -9999.0 0.0 -0.48 51.0 51.0 HHIP -0.17 0.312 -9999.0 0.0 -0.685 64.0 64.0