Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.143 0.164 -9999.0 0.0 -0.331 111.0 111.0 epithelial cell differentiation -0.194 0.221 -9999.0 0.0 -0.448 111.0 111.0 CYFIP2 -0.093 0.255 -9999.0 0.0 -0.796 30.0 30.0 ENAH -0.079 0.158 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.006 0.057 -9999.0 0.0 -0.479 3.0 3.0 EPHA2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.184 0.21 -9999.0 0.0 -0.425 111.0 111.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.061 0.168 -9999.0 0.0 -0.526 30.0 30.0 AQP5 -0.179 0.208 -9999.0 0.0 -0.601 13.0 13.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.181 0.207 -9999.0 0.0 -0.418 111.0 111.0 regulation of calcium-dependent cell-cell adhesion -0.192 0.214 -9999.0 0.0 -0.426 116.0 116.0 EGF -0.315 0.389 -9999.0 0.0 -0.796 102.0 102.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.306 0.309 -9999.0 0.0 -0.739 65.0 65.0 cortical microtubule organization -0.194 0.221 -9999.0 0.0 -0.448 111.0 111.0 GO:0000145 -0.173 0.197 -9999.0 0.0 -0.399 111.0 111.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.196 0.224 -9999.0 0.0 -0.454 111.0 111.0 MLLT4 -0.003 0.049 -9999.0 0.0 -0.796 1.0 1.0 ARF6/GDP -0.151 0.173 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.171 0.194 -9999.0 0.0 -0.394 111.0 111.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.184 0.21 -9999.0 0.0 -0.425 111.0 111.0 ARF6/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.345 0.393 -9999.0 0.0 -0.788 113.0 113.0 EGFR/EGFR/EGF/EGF -0.344 0.317 -9999.0 0.0 -0.565 157.0 157.0 RhoA/GDP -0.182 0.208 -9999.0 0.0 -0.42 111.0 111.0 actin cytoskeleton organization -0.174 0.199 -9999.0 0.0 -0.402 111.0 111.0 IGF-1R heterotetramer -0.009 0.085 -9999.0 0.0 -0.795 3.0 3.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.009 0.085 -9999.0 0.0 -0.796 3.0 3.0 IGF1 -0.02 0.103 -9999.0 0.0 -0.44 12.0 12.0 DIAPH1 -0.102 0.248 -9999.0 0.0 -0.781 30.0 30.0 Wnt receptor signaling pathway 0.194 0.221 0.448 111.0 -9999.0 0.0 111.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.153 0.175 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.178 0.204 -9999.0 0.0 -0.412 111.0 111.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.177 0.197 -9999.0 0.0 -0.402 111.0 111.0 Ephrin A1/EPHA2 -0.176 0.201 -9999.0 0.0 -0.407 111.0 111.0 SEC6/SEC8 -0.162 0.184 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.196 0.218 -9999.0 0.0 -0.433 116.0 116.0 HGF/MET -0.201 0.22 -9999.0 0.0 -0.427 121.0 121.0 HGF -0.038 0.164 -9999.0 0.0 -0.694 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.144 0.165 -9999.0 0.0 -0.334 111.0 111.0 actin cable formation -0.075 0.162 -9999.0 0.0 -0.331 23.0 23.0 KIAA1543 -0.349 0.307 -9999.0 0.0 -0.547 164.0 164.0 KIFC3 -0.186 0.214 -9999.0 0.0 -0.429 111.0 111.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.184 0.21 -9999.0 0.0 -0.425 111.0 111.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.194 0.221 -9999.0 0.0 -0.448 111.0 111.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.184 0.21 -9999.0 0.0 -0.425 111.0 111.0 PIP5K1C -0.184 0.21 -9999.0 0.0 -0.425 111.0 111.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.133 0.153 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.301 0.304 -9999.0 0.0 -0.741 58.0 58.0 IGF-1R heterotetramer/IGF1 -0.19 0.207 -9999.0 0.0 -0.415 116.0 116.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.038 -9999.0 0.0 -0.609 1.0 1.0 MET -0.012 0.098 -9999.0 0.0 -0.796 4.0 4.0 PLEKHA7 -0.191 0.221 -9999.0 0.0 -0.437 112.0 112.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.155 0.175 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.143 0.164 -9999.0 0.0 -0.331 111.0 111.0 regulation of cell-cell adhesion -0.174 0.199 -9999.0 0.0 -0.402 111.0 111.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.144 0.165 -9999.0 0.0 -0.334 111.0 111.0