E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.195 0.233 -9999.0 0.0 -0.459 105.0 105.0 KLHL20 -0.055 0.09 0.167 1.0 -0.234 7.0 8.0 CYFIP2 -0.042 0.175 -9999.0 0.0 -0.549 27.0 27.0 Rac1/GDP -0.112 0.139 -9999.0 0.0 -0.311 58.0 58.0 ENAH -0.196 0.232 -9999.0 0.0 -0.457 106.0 106.0 AP1M1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.095 0.097 -9999.0 0.0 -0.259 2.0 2.0 ABI1/Sra1/Nap1 -0.063 0.064 -9999.0 0.0 -0.187 25.0 25.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.103 0.178 -9999.0 0.0 -0.325 96.0 96.0 RAPGEF1 -0.172 0.203 -9999.0 0.0 -0.404 98.0 98.0 CTNND1 0.019 0.001 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.203 0.238 -9999.0 0.0 -0.467 107.0 107.0 CRK -0.184 0.213 -9999.0 0.0 -0.424 107.0 107.0 E-cadherin/gamma catenin/alpha catenin -0.118 0.186 -9999.0 0.0 -0.352 96.0 96.0 alphaE/beta7 Integrin 0.027 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.029 0.027 -9999.0 0.0 -0.32 1.0 1.0 DLG1 -0.198 0.232 -9999.0 0.0 -0.457 107.0 107.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.075 0.071 -9999.0 0.0 -0.192 3.0 3.0 MLLT4 0.016 0.036 -9999.0 0.0 -0.549 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.036 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.095 0.091 -9999.0 0.0 -0.249 2.0 2.0 ARF6 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.149 0.211 -9999.0 0.0 -0.389 108.0 108.0 TIAM1 0.024 0.036 0.255 6.0 -9999.0 0.0 6.0 E-cadherin(dimer)/Ca2+ -0.098 0.167 -9999.0 0.0 -0.306 96.0 96.0 AKT1 -0.051 0.062 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.015 0.255 1.0 -9999.0 0.0 1.0 CDH1 -0.207 0.278 0.255 2.0 -0.549 101.0 103.0 RhoA/GDP -0.118 0.146 -9999.0 0.0 -0.311 65.0 65.0 actin cytoskeleton organization -0.04 0.069 0.142 2.0 -0.184 4.0 6.0 CDC42/GDP -0.117 0.144 -9999.0 0.0 -0.312 63.0 63.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.103 0.134 -9999.0 0.0 -0.257 107.0 107.0 ITGB7 0.021 0.021 0.255 2.0 -9999.0 0.0 2.0 RAC1 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.103 0.178 -9999.0 0.0 -0.325 96.0 96.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.102 0.16 -9999.0 0.0 -0.302 97.0 97.0 mol:GDP -0.135 0.165 -9999.0 0.0 -0.358 66.0 66.0 CDC42/GTP/IQGAP1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.113 0.155 -9999.0 0.0 -0.319 65.0 65.0 RAC1/GTP/IQGAP1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.026 0.052 0.218 2.0 -0.249 1.0 3.0 NME1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.196 0.23 -9999.0 0.0 -0.452 106.0 106.0 regulation of cell-cell adhesion -0.084 0.085 -9999.0 0.0 -0.228 2.0 2.0 WASF2 -0.032 0.041 -9999.0 0.0 -0.13 1.0 1.0 Rap1/GTP -0.098 0.116 -9999.0 0.0 -0.285 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.09 0.172 -9999.0 0.0 -0.31 91.0 91.0 CCND1 -0.033 0.06 0.231 1.0 -0.314 1.0 2.0 VAV2 -0.187 0.231 -9999.0 0.0 -0.621 12.0 12.0 RAP1/GDP -0.1 0.129 0.221 1.0 -0.304 11.0 12.0 adherens junction assembly -0.19 0.222 -9999.0 0.0 -0.438 106.0 106.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.096 0.161 -9999.0 0.0 -0.302 91.0 91.0 E-cadherin/beta catenin -0.153 0.188 -9999.0 0.0 -0.369 108.0 108.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.197 0.229 -9999.0 0.0 -0.449 107.0 107.0 PIK3CA 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.101 0.126 0.299 1.0 -0.358 10.0 11.0 E-cadherin/beta catenin/alpha catenin -0.12 0.187 -9999.0 0.0 -0.352 97.0 97.0 ITGAE 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.207 0.243 -9999.0 0.0 -0.478 107.0 107.0