rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(12) 306695 12 12 11 3 10 1 1 0 0 0 0.131 0.257 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(5) 219519 5 5 5 1 5 0 0 0 0 0 0.373 0.377 1.000 3 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(6), TAT(21) 1124647 33 21 32 9 24 3 2 1 3 0 0.0125 0.914 1.000 4 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(8), SNAP25(9), VAMP2(1) 1396359 23 21 21 4 16 1 0 3 3 0 0.00233 0.958 1.000 5 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 708066 5 5 4 1 3 0 0 2 0 0 0.339 0.976 1.000 6 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(2) 659766 4 3 4 0 0 2 0 1 1 0 0.334 0.983 1.000 7 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(7), CD3E(2), CD3G(1) 480032 10 7 10 4 8 0 0 0 2 0 0.405 0.993 1.000 8 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(1), ALDOB(14), ALDOC(4), TPI1(1) 1685752 24 19 21 7 17 2 0 2 3 0 0.0344 0.998 1.000 9 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(6), FOSB(6), GRIA2(43), JUND(1), PPP1R1B(2) 1573577 58 50 55 22 35 3 2 9 9 0 0.114 0.998 1.000 10 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 6 CHRM1(5), GNAQ(6), GNB1(1), PLCB1(61), TUB(10) 2651089 83 55 75 29 64 2 2 7 8 0 0.00646 0.999 1.000 11 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), SLPI(6) 734750 15 14 15 7 7 1 0 6 1 0 0.587 0.999 1.000 12 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), CASP3(3), CASP8(9), CFL1(2), CFLAR(5), PDE6D(2) 1669286 24 22 23 9 10 3 3 5 3 0 0.370 0.999 1.000 13 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RELA(4) 3497971 88 61 79 28 66 3 3 8 8 0 0.00919 1.000 1.000 14 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(19), FMOD(6), KERA(16), LUM(12) 1512551 60 45 56 25 46 5 3 3 3 0 0.0224 1.000 1.000 15 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(7), ALDH1A2(16), BCMO1(17), RDH5(2) 1670003 42 35 36 13 29 2 1 4 6 0 0.0148 1.000 1.000 16 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(8), SEC61A2(2), SRP19(3), SRP54(4), SRP68(8), SRP72(1), SRP9(1), SRPR(4) 3260943 31 29 26 7 17 0 1 6 7 0 0.0870 1.000 1.000 17 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(34), GNAS(33), GNB1(1), PRKACA(3), PRKAR1A(3) 2790154 74 51 70 24 46 11 4 7 6 0 0.0123 1.000 1.000 18 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADM(5), ACADS(6), ECHS1(3), HADHA(6) 2335984 25 24 25 9 15 4 1 4 1 0 0.330 1.000 1.000 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1) 2847454 21 18 21 6 5 2 2 4 6 2 0.329 1.000 1.000 20 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(4) 1438077 9 9 9 5 6 0 0 1 2 0 0.721 1.000 1.000 21 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(9), HLA-DRA(13), HLA-DRB1(5) 1006636 29 24 27 15 23 0 0 3 3 0 0.197 1.000 1.000 22 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(16), CCND1(2), CCNE1(4), CCNE2(6), CDK2(1), CDK4(8), CDKN1B(2), E2F1(6), E2F2(5), E2F4(3), PRB1(14) 3587410 67 52 61 20 44 1 4 13 5 0 0.0346 1.000 1.000 23 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(14), LPL(6), NR3C1(7), PPARG(12), RETN(3), RXRA(4), TNF(1) 2489206 47 40 44 17 29 7 0 6 5 0 0.0415 1.000 1.000 24 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(3), CCR3(11), CSF2(2), HLA-DRA(13), HLA-DRB1(5), IL3(3), IL5(4) 1295425 41 29 39 20 33 1 0 4 3 0 0.0602 1.000 1.000 25 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(6), MMP14(3), MMP2(9), MMP9(8), RECK(11), TIMP1(4), TIMP2(2), TIMP3(5), TIMP4(7) 3182420 55 43 53 19 29 4 3 10 9 0 0.0610 1.000 1.000 26 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), CYCS(1), GPD2(3), SDHA(4), SDHC(5), SDHD(2), UQCRC1(4) 2839542 21 18 21 7 13 1 1 4 1 1 0.268 1.000 1.000 27 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 63 48 58 21 36 7 4 9 7 0 0.0100 1.000 1.000 28 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 63 48 58 21 36 7 4 9 7 0 0.0100 1.000 1.000 29 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(2), MYC(5), SP1(5), SP3(1), WT1(10) 2678875 25 21 24 7 14 4 3 1 3 0 0.123 1.000 1.000 30 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(5), PRKCA(9), TGM2(11) 2124288 30 24 29 13 22 2 1 0 5 0 0.0628 1.000 1.000 31 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1942316 11 9 11 9 3 3 1 1 3 0 0.916 1.000 1.000 32 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CCND1(2), CDK2(1), CDK4(8), CDKN1A(3), CDKN1B(2), CFL1(2), E2F1(6), E2F2(5), MDM2(4), NXT1(2), PRB1(14) 2999618 49 43 44 17 27 4 2 10 6 0 0.0953 1.000 1.000 33 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3), NDUFA12(1), NDUFA13(4) 1700209 16 16 15 8 12 2 1 0 1 0 0.586 1.000 1.000 34 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(19), NR0B2(6), NR1H3(5), NR1H4(14), RXRA(4) 2322057 48 35 48 18 31 7 3 5 2 0 0.0359 1.000 1.000 35 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(1), SQLE(4) 1354168 9 9 9 5 4 1 1 3 0 0 0.710 1.000 1.000 36 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6) 2409018 95 71 78 31 77 4 5 6 3 0 0.00551 1.000 1.000 37 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), MIOX(7), UGDH(1) 3615161 58 46 55 21 33 7 6 5 7 0 0.0290 1.000 1.000 38 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), TYR(11) 4128130 77 53 74 23 49 6 2 5 15 0 0.0127 1.000 1.000 39 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(2), DAG1(9), GNAQ(6), ITPKB(11) 2566827 28 24 26 12 20 0 2 2 4 0 0.164 1.000 1.000 40 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2) 2947162 28 23 28 8 15 5 1 4 3 0 0.226 1.000 1.000 41 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(16), GAD1(14), HDC(25), PNMT(4), TH(11), TPH1(12) 2549058 82 61 77 32 63 5 3 1 10 0 0.00163 1.000 1.000 42 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(13), IARS(10), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1) 4290028 67 51 63 20 45 6 2 7 7 0 0.0552 1.000 1.000 43 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(4), EPO(5), FLT3(38), IGF1(11), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(10), TGFB1(2), TGFB2(4), TGFB3(3) 3515566 93 63 87 34 55 6 6 14 12 0 0.0101 1.000 1.000 44 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(4), PAPSS2(5), SULT1A2(3), SULT1E1(16), SULT2A1(9), SUOX(4) 2605387 41 25 39 14 28 1 0 4 8 0 0.110 1.000 1.000 45 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHB(2), LDHC(7), MPST(2) 2934593 39 31 37 16 28 2 6 2 1 0 0.171 1.000 1.000 46 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), KARS(4) 2952936 21 19 21 8 17 0 0 2 2 0 0.449 1.000 1.000 47 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(3), CSF1(12), IL6(2), LDLR(19), LPL(6) 2287921 42 29 41 20 26 7 2 6 1 0 0.259 1.000 1.000 48 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3), YARS2(2) 3720330 69 50 66 29 44 7 2 5 11 0 0.0529 1.000 1.000 49 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT2(4), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(3) 2140316 31 25 30 17 14 6 3 3 5 0 0.291 1.000 1.000 50 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BAD(4), BCAR1(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN2(6), CAV1(1), CAV3(2), CCND1(2), CCND2(7), CCND3(2), CDC42(2), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), CRK(3), CRKL(2), CTNNB1(17), DIAPH1(10), DOCK1(17), EGF(22), EGFR(26), ELK1(3), ERBB2(10), FARP2(7), FIGF(5), FLNA(23), FLNB(45), FLNC(69), FLT1(42), FN1(28), FYN(8), GRB2(2), GSK3B(3), HGF(30), HRAS(6), IBSP(9), IGF1(11), IGF1R(15), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), JUN(1), KDR(57), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), MAP2K1(18), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(5), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(9), PRKCG(17), PTK2(7), PXN(2), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF1(14), RELN(90), RHOA(3), ROCK1(6), ROCK2(14), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(55), TNR(84), TNXB(126), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCL(9), VEGFA(5), VEGFB(3), VTN(9), VWF(60), ZYX(8) 156458284 3604 269 3426 1600 2524 253 106 308 388 25 1.80e-08 1.000 1.000 51 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(19), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), C5AR1(10), CALCR(19), CALCRL(19), CCKAR(12), CCKBR(14), CGA(1), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(13), CNR2(6), CRHR1(9), CRHR2(5), CTSG(5), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2(13), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHB(9), FSHR(21), GABBR1(9), GABBR2(12), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GABRB1(16), GABRB2(26), GABRB3(25), GABRD(5), GABRE(25), GABRG1(38), GABRG2(20), GABRG3(10), GABRP(16), GABRQ(12), GABRR1(10), GALR1(5), GALR3(2), GH1(5), GH2(11), GHR(43), GHRHR(12), GHSR(11), GIPR(4), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(16), GNRHR(3), GPR156(15), GPR35(6), GPR50(19), GPR63(9), GPR83(14), GRIA1(52), GRIA2(43), GRIA3(27), GRIA4(26), GRID1(27), GRID2(60), GRIK1(30), GRIK2(31), GRIK3(35), GRIK4(16), GRIK5(12), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRIN3A(50), GRIN3B(5), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM6(32), GRM7(45), GRM8(50), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HRH4(6), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LEP(4), LEPR(31), LHB(1), LHCGR(29), LTB4R(1), LTB4R2(1), MAS1(4), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), MCHR1(4), MCHR2(21), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPBWR1(3), NPBWR2(12), NPFFR1(1), NPFFR2(15), NPY1R(29), NPY2R(13), NPY5R(25), NR3C1(7), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), P2RY1(5), P2RY10(7), P2RY13(4), P2RY14(8), P2RY2(10), P2RY4(2), P2RY6(2), P2RY8(9), PARD3(20), PRL(3), PRLHR(1), PRLR(38), PRSS1(26), PRSS3(7), PTAFR(2), PTGDR(12), PTGER2(7), PTGER3(11), PTGER4(3), PTGFR(21), PTGIR(5), PTH2R(18), RXFP1(19), RXFP2(25), SCTR(8), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SSTR5(4), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), THRA(2), THRB(18), TRHR(24), TRPV1(4), TSHB(7), TSHR(8), UTS2R(1), VIPR1(8), VIPR2(7) 92963633 2951 261 2714 1781 2032 253 102 267 281 16 5.09e-13 1.000 1.000 52 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(9), ACTG1(7), CHAD(4), COL11A1(80), COL11A2(51), COL17A1(29), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), DES(9), DSC1(58), DSC2(46), DSC3(50), DSG1(64), DSG2(26), DSG3(68), DSG4(70), FN1(28), GJA1(10), GJA10(18), GJA3(1), GJA4(4), GJA5(11), GJA8(20), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(7), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(12), ITGB4(22), KRT1(22), KRT10(14), KRT12(11), KRT13(13), KRT14(3), KRT15(10), KRT16(10), KRT17(4), KRT18(4), KRT19(3), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(14), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(15), KRT33A(6), KRT33B(4), KRT34(12), KRT35(11), KRT36(18), KRT37(13), KRT38(10), KRT39(16), KRT4(22), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(14), KRT7(5), KRT71(18), KRT72(11), KRT73(18), KRT74(16), KRT75(16), KRT76(17), KRT77(15), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(7), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(4), NES(25), PRPH(1), RELN(90), SPP1(7), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VIM(6), VTN(9), VWF(60) 106337368 3242 260 3064 1417 2373 233 79 224 315 18 1.02e-10 1.000 1.000 53 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), DAG1(9), FN1(28), FNDC1(44), FNDC3A(12), FNDC4(5), FNDC5(3), GP5(6), GP6(7), GP9(6), HMMR(5), HSPG2(31), IBSP(9), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), RELN(90), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SPP1(7), SV2A(17), SV2B(27), SV2C(22), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VTN(9), VWF(60) 95453432 2584 258 2464 1108 1866 161 80 180 278 19 9.37e-05 1.000 1.000 54 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY7(13), ADCY8(54), ADCY9(11), ADORA2A(3), ADORA2B(1), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), AGTR1(10), ATP2A1(13), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), ATP2B4(17), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BST1(2), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CCKAR(12), CCKBR(14), CD38(6), CHRM1(5), CHRM2(26), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(12), EDNRB(7), EGFR(26), ERBB2(10), ERBB3(7), ERBB4(59), F2R(8), GNA11(9), GNA14(7), GNA15(7), GNAL(2), GNAQ(6), GNAS(33), GRIN1(11), GRIN2A(107), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), GRPR(7), HRH1(15), HRH2(3), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), LHCGR(29), LTB4R2(1), MYLK(48), MYLK2(13), NOS1(77), NOS3(20), NTSR1(8), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), PDE1A(44), PDE1B(15), PDE1C(54), PDGFRA(32), PDGFRB(23), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTAFR(2), PTGER3(11), PTGFR(21), PTK2B(12), RYR1(114), RYR2(99), RYR3(96), SLC25A6(2), SLC8A1(35), SLC8A2(14), SLC8A3(46), SPHK1(2), SPHK2(8), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), TNNC1(2), TNNC2(5), TRHR(24), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 113096253 2866 256 2691 1775 1998 208 103 228 307 22 1.07e-05 1.000 1.000 55 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ABI2(2), ACTN1(8), ACTN2(21), ACTN4(5), APC(27), APC2(12), ARAF(5), ARHGEF1(2), ARHGEF12(13), ARHGEF4(7), ARHGEF6(11), ARHGEF7(5), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), ARPC5(1), BAIAP2(8), BCAR1(5), BDKRB1(6), BDKRB2(10), CD14(6), CDC42(2), CFL1(2), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(2), CSK(1), CYFIP1(8), CYFIP2(27), DIAPH1(10), DIAPH2(9), DIAPH3(20), DOCK1(17), EGF(22), EGFR(26), EZR(7), F2(13), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FN1(28), GIT1(6), GNA12(3), GNA13(1), GSN(8), HRAS(6), IQGAP1(10), IQGAP2(29), IQGAP3(13), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), KRAS(7), LIMK1(5), LIMK2(12), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(24), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), NCKAP1(5), NCKAP1L(44), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PFN4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(10), PTK2(7), PXN(2), RAC2(2), RAF1(12), RDX(4), RHOA(3), ROCK1(6), ROCK2(14), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(4), TIAM1(28), TIAM2(28), VAV1(19), VAV2(5), VAV3(11), VCL(9), WAS(8), WASF1(5), WASF2(6), WASL(4) 116093151 1992 256 1907 1050 1283 155 74 244 224 12 0.00617 1.000 1.000 56 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 243 ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(4), ARRB2(8), ATF2(6), ATF4(9), BDNF(6), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CACNA2D1(17), CACNA2D2(16), CACNA2D3(61), CACNA2D4(26), CACNB1(4), CACNB2(15), CACNB3(3), CACNB4(14), CACNG1(4), CACNG2(11), CACNG3(25), CACNG4(4), CACNG5(13), CACNG6(6), CACNG7(7), CACNG8(1), CASP3(3), CD14(6), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(3), DUSP1(1), DUSP10(9), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(4), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(22), EGFR(26), ELK1(3), ELK4(6), FAS(5), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FLNA(23), FLNB(45), FLNC(69), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), JUN(1), JUND(1), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(10), MAX(2), MEF2C(5), MKNK1(7), MKNK2(4), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(12), NFATC4(18), NFKB1(6), NFKB2(5), NLK(5), NR4A1(4), NTF3(7), NTRK1(16), NTRK2(11), PAK1(4), PAK2(9), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PPM1A(3), PPM1B(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PPP5C(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTPN5(13), PTPN7(4), PTPRR(30), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(5), RASA2(15), RASGRF1(22), RASGRF2(24), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KA6(21), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(5), STMN1(3), TAOK1(11), TAOK2(28), TAOK3(4), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4), ZAK(8) 119068559 2287 255 2187 1341 1485 214 72 220 279 17 0.292 1.000 1.000 57 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(3), ACVR2A(5), ACVR2B(3), AMHR2(15), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(7), CCL1(3), CCL11(3), CCL14(3), CCL15(3), CCL16(2), CCL18(1), CCL2(3), CCL20(2), CCL21(2), CCL22(2), CCL23(2), CCL24(3), CCL25(2), CCL26(3), CCL27(2), CCL28(1), CCL7(6), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CD27(3), CD40(4), CD40LG(1), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(8), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), CX3CL1(5), CX3CR1(17), CXCL10(3), CXCL11(1), CXCL12(8), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(6), EDA(2), EDA2R(4), EDAR(9), EGF(22), EGFR(26), EPO(5), EPOR(1), FAS(5), FASLG(15), FLT1(42), FLT3(38), FLT3LG(1), FLT4(31), GDF5(16), GH1(5), GH2(11), GHR(43), HGF(30), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL15(4), IL15RA(6), IL17A(8), IL17B(4), IL17RA(5), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL1RAP(3), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL25(1), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), INHBA(20), INHBB(9), INHBC(13), INHBE(5), KDR(57), KIT(13), KITLG(10), LEP(4), LEPR(31), LIF(3), LIFR(39), LTA(5), LTB(3), MET(23), MPL(9), NGFR(8), OSM(5), OSMR(40), PDGFB(6), PDGFC(17), PDGFRA(32), PDGFRB(23), PF4V1(1), PLEKHO2(5), PPBP(6), PRL(3), PRLR(38), RELT(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(11), TNFRSF14(3), TNFRSF17(7), TNFRSF18(5), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFRSF4(5), TNFRSF6B(2), TNFRSF8(19), TNFRSF9(4), TNFSF10(10), TNFSF11(5), TNFSF12(1), TNFSF13B(3), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(49), TSLP(2), VEGFA(5), VEGFB(3), XCL1(1), XCL2(2), XCR1(7) 74935173 1848 253 1759 963 1283 137 49 162 215 2 0.000306 1.000 1.000 58 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(15), ABLIM1(15), ABLIM2(10), ABLIM3(8), ARHGEF12(13), CDC42(2), CDK5(6), CFL1(2), CXCL12(8), CXCR4(3), DCC(102), DPYSL2(4), DPYSL5(15), EFNA1(1), EFNA2(1), EFNA4(4), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(34), EPHA4(22), EPHA5(7), EPHA6(78), EPHA7(54), EPHA8(24), EPHB1(31), EPHB2(36), EPHB3(17), EPHB4(15), EPHB6(26), FES(8), FYN(8), GNAI1(2), GNAI2(6), GNAI3(2), GSK3B(3), HRAS(6), ITGB1(7), KRAS(7), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(50), MAPK1(4), MAPK3(3), MET(23), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NGEF(13), NRP1(24), NTN4(19), NTNG1(15), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(10), PLXNA3(17), PLXNB1(23), PLXNB2(17), PLXNB3(7), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTK2(7), RAC2(2), RASA1(5), RGS3(19), RHOA(3), RHOD(2), RND1(6), ROBO1(25), ROBO2(47), ROBO3(19), ROCK1(6), ROCK2(14), SEMA3A(15), SEMA3C(4), SEMA3D(15), SEMA3E(31), SEMA3F(12), SEMA3G(15), SEMA4A(9), SEMA4B(5), SEMA4C(13), SEMA4D(10), SEMA4F(8), SEMA4G(8), SEMA5A(17), SEMA5B(21), SEMA6A(10), SEMA6B(8), SEMA6C(9), SEMA6D(7), SEMA7A(4), SLIT1(16), SLIT2(66), SLIT3(63), SRGAP1(7), SRGAP2(9), SRGAP3(40), UNC5A(13), UNC5B(12), UNC5C(19), UNC5D(37) 82813689 1777 249 1660 924 1213 146 51 172 186 9 0.00187 1.000 1.000 59 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), ANXA6(6), ARRB1(4), ARRB2(8), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1S(54), CACNB1(4), CACNB3(3), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CASQ1(8), CASQ2(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(10), GJA4(4), GJA5(11), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(9), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), ITPR1(36), ITPR2(20), ITPR3(12), KCNB1(37), KCNJ3(21), KCNJ5(13), MIB1(6), NME7(5), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SLC8A3(46), USP5(8), YWHAB(1), YWHAQ(3) 79216903 1717 241 1617 1165 1170 150 72 133 183 9 0.313 1.000 1.000 60 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(4), ASH1L(37), CASK(6), CDC42(2), CDK4(8), CGN(10), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTTN(5), EPB41(9), EPB41L1(16), EPB41L2(21), EPB41L3(7), EXOC3(6), EXOC4(12), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), HCLS1(15), HRAS(6), IGSF5(12), INADL(43), JAM2(11), JAM3(3), KRAS(7), LLGL1(5), LLGL2(16), MAGI1(38), MAGI2(24), MAGI3(12), MLLT4(17), MPDZ(13), MPP5(1), MRAS(2), MYH1(103), MYH10(14), MYH11(31), MYH13(55), MYH14(24), MYH15(64), MYH2(100), MYH3(31), MYH4(100), MYH6(40), MYH7(58), MYH7B(26), MYH8(66), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), OCLN(6), PARD3(20), PARD6A(1), PARD6B(2), PARD6G(4), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), RAB3B(1), RHOA(3), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(16), TJP2(11), TJP3(20), VAPA(2), YES1(4), ZAK(8) 81814957 1629 240 1516 1023 1090 143 45 161 180 10 0.520 1.000 1.000 61 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(5), ACTN2(21), ACTN4(5), DES(9), DMD(41), MYBPC1(29), MYBPC2(21), MYBPC3(16), MYH3(31), MYH6(40), MYH7(58), MYH8(66), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(130), TNNC2(5), TNNI2(2), TNNI3(3), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(7), TPM2(3), TPM3(2), TPM4(3), TTN(1335), VIM(6) 56716050 1910 238 1744 817 1402 131 65 165 125 22 7.84e-09 1.000 1.000 62 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(7), CADM1(5), CADM3(19), CD2(29), CD22(26), CD226(6), CD274(1), CD276(8), CD28(2), CD34(4), CD4(9), CD40(4), CD40LG(1), CD58(1), CD6(12), CD80(4), CD8A(2), CD8B(9), CD99(1), CDH1(6), CDH15(10), CDH2(16), CDH4(40), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(29), CNTN2(16), CNTNAP1(12), CNTNAP2(94), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(45), ITGA6(12), ITGA8(39), ITGA9(15), ITGAL(27), ITGAM(25), ITGAV(11), ITGB1(7), ITGB2(17), ITGB7(7), ITGB8(19), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(15), MPZ(5), MPZL1(2), NCAM1(18), NCAM2(11), NEGR1(9), NEO1(16), NFASC(52), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(60), NRXN2(20), NRXN3(35), OCLN(6), PDCD1(4), PDCD1LG2(3), PTPRC(36), PTPRF(35), PTPRM(8), PVR(2), PVRL1(4), PVRL2(8), PVRL3(5), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SELE(33), SELL(12), SELP(38), SELPLG(11), SIGLEC1(34), SPN(5), VCAM1(17), VCAN(44) 62115124 1445 236 1363 711 981 108 54 153 144 5 7.49e-05 1.000 1.000 63 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADM(1), ARRB1(4), ARRB2(8), ATF1(5), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(15), ATP2A3(15), CACNB3(3), CALCA(4), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CNN1(9), CNN2(3), CORIN(29), CREB3(1), CRH(4), CRHR1(9), DGKZ(9), ETS2(8), FOS(2), GABPA(6), GABPB2(8), GBA2(2), GJA1(10), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(33), IGFBP1(3), IGFBP2(2), IGFBP3(3), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(13), NFKB1(6), NOS1(77), NOS3(20), OXTR(6), PDE4B(9), PDE4D(8), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(5), PLCG1(9), PLCG2(30), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RLN1(2), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SP1(5), TNXB(126), USP5(8), YWHAB(1), YWHAQ(3) 73876879 1476 234 1399 860 1020 120 53 109 167 7 0.00581 1.000 1.000 64 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(16), CCND1(2), CCND2(7), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(8), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), EP300(19), EPO(5), EPOR(1), GH1(5), GH2(11), GHR(43), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL13RA2(6), IL15(4), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), IRF9(8), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), LIF(3), LIFR(39), MPL(9), MYC(5), OSM(5), OSMR(40), PIAS1(7), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIM1(1), PRL(3), PRLR(38), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(6), SPRED2(4), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), STAM(6), STAM2(3), STAT1(5), STAT2(6), STAT3(11), STAT4(26), STAT5A(3), STAT5B(5), STAT6(9), TPO(49), TSLP(2), TYK2(9) 61933245 1194 232 1148 574 774 98 39 131 150 2 0.0210 1.000 1.000 65 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CCRL2(6), CHML(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(16), CNR1(13), CNR2(6), CX3CR1(17), CXCR3(4), CXCR4(3), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(10), GPR37L1(7), GPR4(5), GPR50(19), GPR6(7), GPR63(9), GPR83(14), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LHCGR(29), LTB4R(1), MAS1(4), MC1R(1), MC3R(8), MC4R(1), MC5R(8), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OR10A5(10), OR11A1(6), OR12D3(9), OR1C1(14), OR1F1(9), OR1Q1(6), OR2H1(12), OR5V1(12), OR7A5(2), OR7C1(3), OR8B8(14), OXTR(6), P2RY1(5), P2RY10(7), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(10), P2RY6(2), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), RGR(8), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SUCNR1(10), TBXA2R(5), TRHR(24) 51252604 1318 228 1228 976 893 135 48 138 101 3 0.000301 1.000 1.000 66 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(27), APC2(12), AXIN1(10), AXIN2(5), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CCND1(2), CCND2(7), CCND3(2), CER1(18), CHD8(30), CREBBP(24), CSNK1A1(5), CSNK1A1L(7), CSNK1E(5), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTBP2(6), CTNNB1(17), CTNNBIP1(1), CUL1(3), DAAM1(8), DAAM2(7), DKK1(3), DKK2(19), DKK4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), FBXW11(6), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LEF1(4), LRP5(21), LRP6(14), MAP3K7(1), MAPK10(9), MAPK8(3), MAPK9(4), MMP7(4), MYC(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKD1(9), NKD2(7), NLK(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRICKLE1(11), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PSEN1(3), RAC2(2), RHOA(3), ROCK1(6), ROCK2(14), RUVBL1(1), SENP2(9), SFRP1(4), SFRP2(9), SFRP4(6), SFRP5(1), SMAD2(5), SMAD3(4), SMAD4(2), SOX17(8), TBL1X(4), TBL1XR1(3), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(8), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6) 67919409 1012 225 969 499 642 88 44 110 122 6 0.0359 1.000 1.000 67 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(16), EGF(22), EGFR(26), GJA1(10), GJD2(5), GNA11(9), GNAI1(2), GNAI2(6), GNAI3(2), GNAQ(6), GNAS(33), GRB2(2), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), HTR2A(11), HTR2B(2), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K5(5), MAP3K2(8), MAPK1(4), MAPK3(3), MAPK7(4), NPR1(17), NPR2(21), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), PRKX(3), RAF1(12), SOS1(10), SOS2(13), SRC(2), TJP1(16), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12) 55449196 1148 222 1064 628 780 90 44 108 121 5 0.00113 1.000 1.000 68 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(24), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BAD(4), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(16), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(3), EXOC7(8), FASN(26), FBP1(3), FBP2(2), FLOT1(2), FOXO1(6), G6PC(6), G6PC2(3), GCK(16), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(6), IKBKB(4), INPP5D(39), INSR(23), IRS1(5), IRS2(3), IRS4(11), KRAS(7), LIPE(10), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MKNK1(7), MKNK2(4), PCK1(28), PCK2(6), PDE3A(30), PDE3B(6), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PKLR(14), PPARGC1A(26), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R3A(64), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(3), PRKX(3), PTPN1(4), PTPRF(35), PYGB(3), PYGL(9), PYGM(14), RAF1(12), RAPGEF1(14), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(4), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SLC2A4(8), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(16), SOS1(10), SOS2(13), SREBF1(5), TRIP10(7), TSC1(9), TSC2(14) 67283197 1080 222 1027 539 705 94 40 113 124 4 0.0163 1.000 1.000 69 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADK(5), ADSL(6), ADSS(2), ADSSL1(9), AK1(1), AK2(3), AK5(11), AK7(27), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(2), GART(10), GDA(16), GMPR(2), GMPR2(2), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NPR1(17), NPR2(21), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(13), PDE11A(20), PDE1A(44), PDE1C(54), PDE2A(17), PDE3B(6), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PDE9A(13), PFAS(12), PKLR(14), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4), RRM2B(2), XDH(61) 69521955 1220 221 1159 616 833 97 54 113 121 2 0.000624 1.000 1.000 70 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(20), AMY2A(7), AMY2B(14), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(3), ENPP1(13), ENPP3(15), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), G6PC(6), G6PC2(3), GAA(8), GANC(6), GBA(7), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), IFIH1(10), MGAM(190), MOV10L1(25), NUDT5(1), NUDT8(2), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), RAD54B(8), RUVBL2(5), SETX(19), SI(94), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(4), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UXS1(6) 52325225 1111 219 1015 485 768 86 44 84 126 3 1.73e-05 1.000 1.000 71 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(32), BDKRB1(6), BDKRB2(10), C1QA(6), C1QB(7), C1QC(10), C1R(17), C1S(20), C2(9), C3(55), C3AR1(6), C4BPA(16), C4BPB(6), C5(23), C5AR1(10), C6(72), C7(49), C8B(47), C8G(1), C9(22), CD46(1), CD55(6), CD59(1), CFB(51), CFH(51), CFI(18), CPB2(1), CR1(53), CR2(36), F10(10), F11(14), F12(1), F13A1(26), F13B(35), F2(13), F2R(8), F3(2), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), KNG1(15), MASP1(20), MASP2(11), MBL2(14), PLAT(5), PLAU(3), PLAUR(4), PLG(36), PROC(11), PROS1(17), SERPINA1(10), SERPINA5(10), SERPINC1(7), SERPIND1(5), SERPINE1(6), SERPINF2(7), SERPING1(14), TFPI(8), THBD(2), VWF(60) 37951820 1214 218 1136 522 856 79 51 110 109 9 7.13e-05 1.000 1.000 72 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(25), CD14(6), CD19(8), CD1A(14), CD1B(14), CD1C(28), CD1D(10), CD1E(29), CD2(29), CD22(26), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD44(5), CD5(8), CD55(6), CD59(1), CD7(2), CD8A(2), CD8B(9), CR1(53), CR2(36), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF3(4), CSF3R(11), DNTT(10), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(38), FLT3LG(1), GP5(6), GP9(6), GYPA(10), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL2RA(7), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL7(5), IL7R(37), IL9R(9), ITGA1(23), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGAM(25), ITGB3(25), KIT(13), KITLG(10), MME(25), MS4A1(8), TFRC(4), THPO(10), TNF(1), TPO(49) 34627332 1003 217 931 469 697 53 36 83 129 5 0.000556 1.000 1.000 73 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(5), CACNA1A(38), CRH(4), CRHR1(9), GNA11(9), GNA12(3), GNA13(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GNAZ(7), GRIA1(52), GRIA2(43), GRIA3(27), GRID2(60), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), IGF1(11), IGF1R(15), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), LYN(11), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), NOS1(77), NOS3(20), NPR1(17), NPR2(21), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), RAF1(12), RYR1(114) 45780662 1207 216 1100 639 839 81 37 106 134 10 6.10e-05 1.000 1.000 74 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(4), AKT3(3), BCAR1(5), CAPN1(5), CAPN10(8), CAPN11(10), CAPN2(6), CAPN3(9), CAPN5(6), CAPN6(14), CAPN7(2), CAPN9(12), CAPNS1(3), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(8), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(17), MAPK6(8), MAPK7(4), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PDPK1(5), PIK3R2(6), PTK2(7), PXN(2), RAC2(2), RAP1B(1), RAPGEF1(14), RHO(2), ROCK1(6), ROCK2(14), SDCCAG8(3), SEPP1(13), SHC1(2), SHC3(15), SORBS1(16), SOS1(10), SRC(2), TLN1(12), TNS1(11), VASP(3), VAV2(5), VAV3(11), VCL(9), ZYX(8) 56385265 918 215 882 470 590 72 36 122 94 4 0.0421 1.000 1.000 75 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(8), ACTN2(21), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), CXCL12(8), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(7), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), ITK(25), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(17), MMP2(9), MMP9(8), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NCF1(3), NCF2(8), NCF4(8), NOX1(13), NOX3(7), OCLN(6), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAC2(2), RAP1A(1), RAP1B(1), RAPGEF3(14), RAPGEF4(19), RASSF5(4), RHOA(3), RHOH(5), ROCK1(6), ROCK2(14), SIPA1(9), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCAM1(17), VCL(9) 52458635 909 214 866 480 594 71 30 103 106 5 0.0175 1.000 1.000 76 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(34), ADCY8(54), ARAF(5), ATF4(9), CACNA1C(60), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(19), GNAQ(6), GRIA1(52), GRIA2(43), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF3(14), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21) 41118623 1015 214 935 582 681 85 40 99 104 6 0.0753 1.000 1.000 77 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C1(3), AKR1C2(5), AKR1C3(12), AKR1C4(10), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2F1(13), CYP2S1(14), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(2), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19) 24369215 878 212 787 381 630 53 37 54 101 3 1.43e-09 1.000 1.000 78 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(18), ABCA10(24), ABCA12(80), ABCA13(80), ABCA2(14), ABCA3(16), ABCA4(58), ABCA5(12), ABCA6(30), ABCA7(18), ABCA8(38), ABCA9(22), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(53), ABCB6(2), ABCB7(6), ABCB8(4), ABCB9(7), ABCC1(15), ABCC10(15), ABCC11(19), ABCC12(26), ABCC2(12), ABCC3(32), ABCC4(14), ABCC5(12), ABCC6(31), ABCC8(44), ABCC9(62), ABCD1(1), ABCD2(22), ABCD3(12), ABCD4(3), ABCG1(12), ABCG2(5), ABCG4(7), ABCG5(6), ABCG8(13), CFTR(62), TAP1(2), TAP2(14) 50128219 1039 212 976 586 685 84 35 109 120 6 0.00316 1.000 1.000 79 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPP5D(39), INPPL1(16), ITPK1(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), OCRL(7), PI4KA(22), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PRKCA(9), PRKCG(17), SYNJ1(23), SYNJ2(22) 52369739 972 210 900 455 680 52 39 82 113 6 1.18e-05 1.000 1.000 80 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ASIP(1), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CREB3(1), CREB3L1(7), CREB3L2(11), CREB3L3(13), CREB3L4(7), CREBBP(24), CTNNB1(17), DCT(4), DVL1(1), DVL2(3), DVL3(9), EDN1(9), EDNRB(7), EP300(19), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GSK3B(3), HRAS(6), KIT(13), KITLG(10), KRAS(7), LEF1(4), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MC1R(1), MITF(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), POMC(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), TCF7(1), TCF7L1(4), TCF7L2(8), TYR(11), TYRP1(9), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6) 45900891 869 210 807 455 545 83 47 93 97 4 0.00280 1.000 1.000 81 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ATF4(9), CACNA1C(60), CACNA1D(36), CACNA1F(24), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDC42(2), CGA(1), EGFR(26), ELK1(3), FSHB(9), GNA11(9), GNAQ(6), GNAS(33), GNRH2(2), GNRHR(3), GRB2(2), HBEGF(1), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), KRAS(7), LHB(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK9(4), MMP14(3), MMP2(9), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLD1(15), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCD(5), PRKX(3), PTK2B(12), RAF1(12), SOS1(10), SOS2(13), SRC(2) 53527497 1037 209 972 631 672 95 46 101 118 5 0.225 1.000 1.000 82 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(6), ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(8), CDC42(2), CDH1(6), CREBBP(24), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), EGFR(26), EP300(19), ERBB2(10), FARP2(7), FER(3), FGFR1(12), FYN(8), IGF1R(15), INSR(23), IQGAP1(10), LEF1(4), LMO7(30), MAP3K7(1), MAPK1(4), MAPK3(3), MET(23), MLLT4(17), NLK(5), PARD3(20), PTPN1(4), PTPN6(5), PTPRB(97), PTPRF(35), PTPRJ(9), PTPRM(8), PVRL1(4), PVRL2(8), PVRL3(5), PVRL4(10), RAC2(2), RHOA(3), SMAD2(5), SMAD3(4), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(16), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(8), TGFBR2(9), TJP1(16), VCL(9), WAS(8), WASF1(5), WASF2(6), WASF3(14), WASL(4), YES1(4) 50962794 768 203 730 386 496 67 33 80 87 5 0.225 1.000 1.000 83 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADK(5), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(11), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), FHIT(2), GART(10), GDA(16), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NPR1(17), NPR2(21), NT5E(7), NT5M(2), NUDT2(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(44), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6B(16), PDE6C(25), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(13), PFAS(12), PKLR(14), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4) 54462095 941 202 885 486 640 77 34 92 96 2 0.00292 1.000 1.000 84 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(6), B3GNT1(3), B3GNT2(2), B3GNT6(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), CHPF(4), CHST1(11), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), FUT11(4), FUT8(8), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GANAB(6), GCNT1(6), GCNT3(8), GCNT4(3), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), NDST1(6), NDST2(2), NDST3(25), NDST4(51), OGT(9), RPN2(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GAL1(8), ST6GALNAC1(8), STT3B(5), WBSCR17(46), XYLT1(12), XYLT2(5) 46699723 760 201 730 404 487 66 35 79 93 0 0.0488 1.000 1.000 85 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(15), ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), ATM(16), ATR(22), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDC14A(6), CDC14B(3), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(14), CDC6(2), CDC7(3), CDK2(1), CDK4(8), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(3), DBF4(6), E2F1(6), E2F2(5), E2F3(4), EP300(19), ESPL1(19), FZR1(8), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(22), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), RBL2(6), SFN(2), SKP2(3), SMAD2(5), SMAD3(4), SMAD4(2), SMC1A(3), SMC1B(25), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 57462260 546 200 533 247 309 49 37 92 57 2 0.184 1.000 1.000 86 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(5), CASP3(3), CD244(10), CD247(4), CD48(8), CSF2(2), FAS(5), FASLG(15), FCER1G(1), FCGR3A(9), FCGR3B(8), FYN(8), GRB2(2), GZMB(4), HLA-A(4), HLA-B(6), HLA-C(2), HLA-E(1), HLA-G(5), HRAS(6), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), ITGAL(27), ITGB2(17), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KLRC1(4), KLRC2(7), KLRC3(8), KLRD1(7), KLRK1(7), KRAS(7), LAT(3), LCK(17), LCP2(8), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MICA(4), MICB(7), NCR1(18), NCR3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK1(4), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRF1(14), PRKCA(9), PRKCG(17), PTK2B(12), PTPN11(10), PTPN6(5), RAC2(2), RAF1(12), SH2D1A(3), SH2D1B(5), SH3BP2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SYK(15), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFSF10(10), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(6), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 46874525 900 200 856 451 582 71 33 99 111 4 0.0350 1.000 1.000 87 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), AKAP1(12), AKAP10(3), AKAP11(12), AKAP12(6), AKAP3(17), AKAP4(19), AKAP6(41), AKAP7(3), AKAP8(7), AKAP9(38), ARHGEF1(2), CALM1(1), CALM2(1), CHMP1B(1), GNA11(9), GNA12(3), GNA13(1), GNA14(7), GNA15(7), GNAI2(6), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(3), GNG10(1), GNG4(3), GNG7(2), GNGT2(5), HRAS(6), ITPR1(36), KCNJ3(21), KRAS(7), PALM2(3), PDE1A(44), PDE1B(15), PDE1C(54), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(5), USP5(8) 49567071 831 199 791 493 570 64 36 78 83 0 0.469 1.000 1.000 88 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(15), ACTN1(8), ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGEF6(11), ARHGEF7(5), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(36), FYN(8), GRB2(2), GRB7(9), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGB3BP(3), MAP2K4(4), MAP2K7(7), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(48), MYLK2(13), P4HB(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PKLR(14), PLCG1(9), PLCG2(30), PTK2(7), RAF1(12), RALA(1), RHO(2), ROCK1(6), ROCK2(14), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(2), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8) 50580065 813 199 773 416 521 68 29 109 84 2 0.118 1.000 1.000 89 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(41), CBL(10), CBLB(21), CBLC(16), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD40LG(1), CD8A(2), CD8B(9), CDC42(2), CDK4(8), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(8), GRAP2(7), GRB2(2), HRAS(6), ICOS(3), IFNG(4), IKBKB(4), IL10(2), IL2(4), IL4(1), IL5(4), ITK(25), JUN(1), KRAS(7), LAT(3), LCK(17), LCP2(8), MALT1(8), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCQ(21), PTPN6(5), PTPRC(36), RASGRP1(11), RHOA(3), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 43011853 730 198 694 349 457 60 28 91 89 5 0.0876 1.000 1.000 90 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(15), ABL2(12), AKT1(4), AKT2(8), AKT3(3), ARAF(5), AREG(8), BAD(4), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CBL(10), CBLB(21), CBLC(16), CDKN1A(3), CDKN1B(2), CRK(3), CRKL(2), EGF(22), EGFR(26), EIF4EBP1(1), ELK1(3), ERBB2(10), ERBB3(7), ERBB4(59), EREG(4), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(6), JUN(1), KRAS(7), MAP2K1(18), MAP2K2(5), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MYC(5), NCK1(2), NCK2(5), NRG1(23), NRG2(9), NRG3(24), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), RAF1(12), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(5), TGFA(2) 42912773 758 197 713 366 476 64 34 92 90 2 0.0908 1.000 1.000 91 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(6), CD40(4), CD80(4), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IKBKB(4), IKBKE(9), IL12A(4), IL12B(3), IL1B(8), IL6(2), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(10), LY96(4), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(3), TICAM1(8), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(42), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(18), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 37684887 571 197 545 289 368 40 29 72 60 2 0.0401 1.000 1.000 92 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(20), AMY2A(7), AMY2B(14), ENPP1(13), ENPP3(15), G6PC(6), GAA(8), GANAB(6), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), MGAM(190), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), SI(94), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UXS1(6) 24148111 691 196 624 297 485 63 28 48 65 2 5.04e-05 1.000 1.000 93 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(5), ACVR2B(3), ACVRL1(12), AMHR2(15), BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BMPR1A(2), BMPR1B(4), BMPR2(7), CHRD(21), COMP(8), CREBBP(24), CUL1(3), DCN(19), E2F4(3), E2F5(3), EP300(19), FST(6), GDF5(16), GDF6(2), GDF7(1), ID1(1), ID2(2), IFNG(4), INHBA(20), INHBB(9), INHBC(13), INHBE(5), LEFTY1(9), LEFTY2(4), LTBP1(46), MAPK1(4), MAPK3(3), MYC(5), NODAL(2), NOG(2), PITX2(6), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), RBL1(14), RBL2(6), RHOA(3), ROCK1(6), ROCK2(14), RPS6KB1(4), RPS6KB2(2), SMAD1(5), SMAD2(5), SMAD3(4), SMAD4(2), SMAD5(2), SMAD6(7), SMAD7(1), SMAD9(12), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNF(1), ZFYVE16(7), ZFYVE9(8) 42268096 637 192 607 287 402 60 30 63 82 0 0.0335 1.000 1.000 94 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), F10(10), F11(14), F12(1), F2(13), F2R(8), F5(39), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), PROC(11), PROS1(17), SERPINC1(7), SERPING1(14) 18897075 671 190 622 183 500 40 19 54 53 5 0.000597 1.000 1.000 95 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(3), ACVRL1(12), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(7), BUB1(6), CDKL1(1), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MAP3K10(13), MOS(6), NEK1(7), NEK3(2), OCRL(7), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PIM2(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKG1(15), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(4), STK11(4), VRK1(1) 47819286 782 190 727 415 532 48 27 77 94 4 0.262 1.000 1.000 96 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(10), AGTR2(10), ATP8A1(33), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CX3CR1(17), CXCR3(4), CXCR4(3), CXCR6(6), EDNRA(12), EDNRB(7), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(3), GRPR(7), LHCGR(29), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), NMBR(8), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), TACR1(8), TACR2(9), TACR3(29), TRHR(24), TSHR(8) 22324664 620 189 582 417 429 53 26 60 52 0 0.000306 1.000 1.000 97 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(1), ACMSD(13), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CAT(8), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADHA(6), KMO(8), KYNU(16), MAOA(4), MAOB(13), SDS(3), TDO2(4), TPH1(12), WARS(5), WARS2(4) 23386276 609 188 573 341 438 39 20 44 65 3 0.0342 1.000 1.000 98 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(9), BAD(4), BCL2(3), CABIN1(17), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(13), CREBBP(24), CSF2(2), CSNK2A1(2), CSNK2B(1), CTLA4(2), EGR2(5), EGR3(4), EP300(19), FCER1A(17), FCGR3A(9), FOS(2), GATA3(9), GATA4(5), GSK3A(1), GSK3B(3), HRAS(6), ICOS(3), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL13(2), IL1B(8), IL2(4), IL2RA(7), IL3(3), IL4(1), IL6(2), ITK(25), KPNA5(2), MAP2K7(7), MAPK14(5), MAPK8(3), MAPK9(4), MEF2A(3), MEF2B(3), MEF2D(6), MYF5(16), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB2(5), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PTPRC(36), RELA(4), RPL13A(2), SFN(2), SLA(4), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(5), VAV3(11), XPO5(8) 38810128 562 184 540 312 370 40 24 49 74 5 0.572 1.000 1.000 99 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(10), AKR1D1(21), ARSD(3), ARSE(5), CARM1(7), CYP11B1(19), CYP11B2(12), CYP19A1(16), HEMK1(4), HSD11B1(14), HSD11B2(2), HSD17B12(4), HSD17B2(13), HSD17B3(5), HSD17B7(1), HSD3B1(15), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(6), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), WBSCR22(2) 21258474 613 183 550 249 423 55 21 41 71 2 7.21e-08 1.000 1.000 100 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AKR1A1(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(4), DGAT1(1), DGAT2(7), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), GPAM(6), LCT(54), LIPA(5), LIPC(10), LIPF(17), LIPG(10), LPL(6), MGLL(11), PNLIP(9), PNLIPRP1(10), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10) 24538582 523 181 479 223 350 48 21 51 51 2 1.62e-05 1.000 1.000 101 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(9), ADCY8(54), CACNA1A(38), CACNA1B(40), GNAS(33), GNAT3(5), GNB1(1), GNB3(7), GRM4(22), ITPR3(12), KCNB1(37), PDE1A(44), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), SCNN1A(12), SCNN1B(16), SCNN1G(33), TAS1R1(14), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(5), TAS2R16(10), TAS2R3(2), TAS2R38(19), TAS2R39(14), TAS2R4(4), TAS2R40(6), TAS2R41(13), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(20), TAS2R7(5), TAS2R8(5), TAS2R9(10), TRPM5(14) 24119177 598 180 559 466 402 43 28 60 62 3 0.758 1.000 1.000 102 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPPL1(16), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(11), MINPP1(1), MIOX(7), OCRL(7), PI4KA(22), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), SYNJ1(23), SYNJ2(22) 31106789 577 179 543 265 396 31 28 53 66 3 0.000393 1.000 1.000 103 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(15), CARD11(41), CD19(8), CD22(26), CD72(5), CD79A(4), CD81(3), CHUK(2), CR2(36), FCGR2B(3), FOS(2), GSK3B(3), HRAS(6), IKBKB(4), INPP5D(39), JUN(1), KRAS(7), LILRB3(4), LYN(11), MALT1(8), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTPN6(5), RAC2(2), RASGRP3(12), SYK(15), VAV1(19), VAV2(5), VAV3(11) 31376463 545 179 525 249 345 37 27 60 69 7 0.00870 1.000 1.000 104 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(4), AKT2(8), AKT3(3), BTK(15), CSF2(2), FCER1A(17), FCER1G(1), FYN(8), GAB2(4), GRB2(2), HRAS(6), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(39), KRAS(7), LAT(3), LCP2(8), LYN(11), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MS4A2(13), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PRKCA(9), PRKCD(5), PRKCE(7), RAC2(2), RAF1(12), SOS1(10), SOS2(13), SYK(15), TNF(1), VAV1(19), VAV2(5), VAV3(11) 30376442 549 178 520 243 344 42 18 65 76 4 0.00174 1.000 1.000 105 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(15), ALG6(2), CCKBR(14), CCR2(17), CCR3(11), CCR5(10), CELSR1(31), CELSR2(26), CELSR3(32), CHRM2(26), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(12), EMR2(6), EMR3(22), F2R(8), FSHR(21), GHRHR(12), GNRHR(3), GPR116(38), GPR132(3), GPR133(16), GPR143(4), GPR17(1), GPR18(5), GPR55(6), GPR61(7), GPR84(9), GRM1(13), GRPR(7), HRH4(6), LGR6(22), LPHN2(50), LPHN3(24), LTB4R2(1), NTSR1(8), OR2M4(14), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1) 28348932 588 177 556 375 387 50 25 62 61 3 0.0585 1.000 1.000 106 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(6), ACADL(5), ACADM(5), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ANGPTL4(5), APOA1(1), APOA2(1), APOA5(5), APOC3(2), AQP7(5), CD36(6), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP27A1(4), CYP4A11(32), CYP4A22(27), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(7), FABP3(1), FABP4(2), FABP7(1), FADS2(4), GK(7), HMGCS2(18), ILK(2), LPL(6), ME1(22), MMP1(14), NR1H3(5), OLR1(6), PCK1(28), PCK2(6), PDPK1(5), PLTP(1), PPARA(8), PPARD(3), PPARG(12), RXRA(4), RXRB(4), RXRG(6), SCD(4), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(6), SLC27A5(10), SLC27A6(34), SORBS1(16), UBC(6), UCP1(5) 27471534 552 177 514 289 376 53 21 38 61 3 0.0456 1.000 1.000 107 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(15), ATM(16), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(3), CDH1(6), CDK2(1), CDK4(8), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), EP300(19), ESPL1(19), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), HDAC8(5), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MPEG1(6), MPL(9), PCNA(2), PLK1(4), PRKDC(22), PTPRA(9), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), SKP2(3), SMAD4(2), TBC1D8(11), TFDP1(2), TGFB1(2), WEE1(2) 46113359 436 176 425 216 258 42 22 69 43 2 0.333 1.000 1.000 108 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(14), EGFR(26), ERBB2(10), ERBB4(59), ETS1(4), ETS2(8), ETV6(10), ETV7(7), FMN2(87), GRB2(2), KRAS(7), MAP2K1(18), MAPK1(4), MAPK3(3), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), PIWIL1(23), PIWIL2(13), PIWIL3(16), PIWIL4(4), RAF1(12), SOS1(10), SOS2(13), SPIRE1(3), SPIRE2(7) 21721514 485 174 459 216 336 33 14 56 45 1 0.100 1.000 1.000 109 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(8), AGTR1(10), AGTR2(10), CMA1(6), COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), REN(12) 10723906 437 172 404 109 339 20 8 25 40 5 0.0512 1.000 1.000 110 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(6), CHUK(2), DAXX(10), ELK1(3), FOS(2), GRB2(2), HRAS(6), IKBKB(4), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(27), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAP4K5(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK4(17), MAPK6(8), MAPK7(4), MAPK8(3), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MKNK2(4), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(9), RAF1(12), RELA(4), RIPK1(3), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2) 39425216 479 172 459 239 285 50 23 65 55 1 0.389 1.000 1.000 111 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(12), CAMK4(17), CREBBP(24), CSNK1A1(5), EDN1(9), ELSPBP1(8), F2(13), FGF2(2), GATA4(5), GSK3B(3), HAND1(2), HAND2(5), HRAS(6), IGF1(11), LIF(3), MAP2K1(18), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MEF2C(5), MYH2(100), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKX2-5(1), NPPA(5), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(12), RPS6KB1(4), SYT1(23) 21667767 444 172 407 240 294 43 16 41 45 5 0.421 1.000 1.000 112 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(5), ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), G6PC2(3), GALM(2), GAPDH(3), GAPDHS(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGAM4(1), PGK1(3), PGK2(36), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 24794019 414 170 379 200 279 29 25 40 41 0 0.00182 1.000 1.000 113 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN1(5), CAPN2(6), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CSF2RB(25), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL3(3), IL3RA(8), IRAK1(5), IRAK2(15), IRAK3(11), IRAK4(3), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(10), TRAF2(2) 35079562 453 170 439 261 281 34 21 58 58 1 0.858 1.000 1.000 114 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(4), AKT2(8), AKT3(3), BAD(4), CASP9(2), CDC42(2), HRAS(6), KDR(57), KRAS(7), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NOS3(20), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCA(9), PRKCG(17), PTGS2(13), PTK2(7), PXN(2), RAC2(2), RAF1(12), SH2D2A(5), SHC2(7), SPHK1(2), SPHK2(8), SRC(2), VEGFA(5) 30374064 538 170 510 247 349 38 15 68 65 3 0.00697 1.000 1.000 115 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(16), EGFR(26), EPHB2(36), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(10), PITX2(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), RAF1(12), RGS20(3), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(11), TERF2IP(2) 24252675 469 169 434 260 314 40 20 44 47 4 0.167 1.000 1.000 116 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(23), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(10), CD36(6), CHUK(2), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), G6PC(6), G6PC2(3), IKBKB(4), IRS1(5), IRS2(3), IRS4(11), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), MAPK10(9), MAPK8(3), MAPK9(4), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(28), PCK2(6), POMC(4), PPARA(8), PPARGC1A(26), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKCQ(21), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(8), SOCS3(1), STAT3(11), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(9) 35378840 533 168 513 305 340 49 23 52 69 0 0.581 1.000 1.000 117 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(7), CLK2(8), CLK3(2), COL2A1(44), CPSF1(8), CPSF2(2), CPSF3(3), CSTF1(6), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(4), DDX20(11), DHX15(5), DHX16(9), DHX38(10), DHX8(11), DHX9(11), DICER1(23), DNAJC8(2), FUS(1), GIPC1(6), LSM7(2), METTL3(3), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(2), PAPOLA(4), PHF5A(2), POLR2A(14), PPM1G(2), PRPF18(4), PRPF3(6), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(5), PTBP2(8), RBM17(1), RBM5(10), RNGTT(3), RNMT(9), RNPS1(2), SF3A1(6), SF3A2(6), SF3A3(7), SF3B1(17), SF3B2(11), SF3B4(9), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(2), SNRPF(1), SNRPN(7), SNURF(3), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(9), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6) 45295081 437 168 430 181 252 34 29 59 62 1 0.262 1.000 1.000 118 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AKR1A1(4), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), LCT(54), LIPC(10), LIPF(17), LIPG(10), LPL(6), PNLIP(9), PNLIPRP1(10), PPAP2A(1), PPAP2B(11), PPAP2C(10) 20528996 450 167 410 201 313 39 17 40 39 2 0.000233 1.000 1.000 119 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(12), ALOX12(6), ALOX12B(16), ALOX15(11), ALOX15B(9), ALOX5(14), CBR3(1), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP2U1(2), CYP4A11(32), CYP4A22(27), CYP4F2(17), CYP4F3(26), EPHX2(6), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), LTA4H(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 16489245 573 165 533 329 420 40 10 35 65 3 0.00627 1.000 1.000 120 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), P4HB(3), SLC23A1(6), SLC23A2(4), SLC2A1(5), SLC2A3(7) 10605285 410 164 379 87 318 18 10 24 36 4 0.000227 1.000 1.000 121 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), PON1(15) 12424580 438 163 408 255 329 24 11 20 52 2 0.00670 1.000 1.000 122 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(4), BDKRB2(10), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(8), FLT1(42), FLT4(31), KDR(57), NOS3(20), PDE2A(17), PDE3A(30), PDE3B(6), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(15), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23) 17323211 423 163 399 237 285 36 10 42 48 2 0.211 1.000 1.000 123 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(4), AKT2(8), AKT3(3), BAD(4), CDC42(2), CDK2(1), CDKN1B(2), CREB3(1), CREB5(9), ERBB4(59), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), MET(23), MYC(5), NOLC1(7), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(10), PTK2(7), PTPN1(4), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SLC2A4(8), SOS1(10), SOS2(13), TSC1(9), TSC2(14), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 32347743 453 163 434 249 276 44 23 58 51 1 0.720 1.000 1.000 124 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(16), CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG2(1), CCNH(2), CDC25A(8), CDK2(1), CDK4(8), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CREB3(1), CREB3L1(7), CREB3L3(13), CREB3L4(7), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MNAT1(2), MYC(5), MYT1(21), NACA(44), PCNA(2), POLA2(9), POLE(16), POLE2(2), PRIM1(3), RB1(10), RBL1(14), RPA1(3), RPA2(2), TFDP1(2), TFDP2(3), TNXB(126), WEE1(2) 32924192 442 162 429 199 290 38 18 57 37 2 0.0284 1.000 1.000 125 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(2), ALAS2(6), BLVRA(2), BLVRB(1), COX10(8), COX15(4), CP(14), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UROS(1) 17947818 454 161 405 168 318 34 18 27 55 2 2.18e-06 1.000 1.000 126 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BTRC(4), CSNK1A1(5), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(44), GLI3(19), GSK3B(3), HHIP(27), IHH(4), LRP2(108), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), PTCH1(6), PTCH2(18), RAB23(1), SHH(3), SMO(10), STK36(17), SUFU(3), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6), ZIC2(3) 25738464 520 161 484 260 355 47 20 50 48 0 0.0277 1.000 1.000 127 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), BCR(14), BLNK(15), BTK(15), CD19(8), CD22(26), CD81(3), CR2(36), CSK(1), DAG1(9), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(39), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), MAP4K1(12), MAPK1(4), MAPK3(3), NFATC1(18), NFATC2(12), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(36), RAF1(12), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 31460302 511 160 487 255 326 39 27 52 62 5 0.0449 1.000 1.000 128 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(7), ACTG2(6), ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), CDC42(2), CFL1(2), FLNA(23), FLNC(69), FSCN1(4), FSCN2(2), FSCN3(13), GDI1(2), GDI2(3), LIMK1(5), MYH2(100), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(6), ROCK2(14), VASP(3), WASF1(5), WASL(4) 20341404 438 160 402 236 303 46 12 39 36 2 0.0237 1.000 1.000 129 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP4A11(32), CYP4A22(27), ECHS1(3), EHHADH(6), GCDH(7), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6) 20936387 404 159 370 166 288 27 23 24 41 1 0.000107 1.000 1.000 130 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), RRM1(3), RRM2(4), RRM2B(2), TK1(1), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UPB1(14), UPP1(1), UPP2(6), UPRT(1) 34487643 444 159 417 225 286 36 15 64 42 1 0.163 1.000 1.000 131 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(37), ASH2L(5), CARM1(7), CTCFL(21), DOT1L(12), EED(3), EHMT1(11), EHMT2(11), EZH1(10), EZH2(13), FBXO11(7), HCFC1(21), HSF4(1), JMJD4(7), JMJD6(2), KDM6A(3), MEN1(3), MLL3(2), NSD1(21), OGT(9), PAXIP1(3), PPP1CA(3), PPP1CB(5), PPP1CC(2), PRDM2(15), PRDM7(5), PRDM9(51), PRMT1(3), PRMT5(7), PRMT7(4), PRMT8(10), RBBP5(4), SATB1(22), SETD1A(27), SETD2(16), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(8), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(3), WHSC1(10), WHSC1L1(6) 50390913 447 158 433 197 283 51 13 62 38 0 0.387 1.000 1.000 132 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3) 22350623 380 158 361 169 235 37 15 49 43 1 0.00369 1.000 1.000 133 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3) 22350623 380 158 361 169 235 37 15 49 43 1 0.00369 1.000 1.000 134 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGAP1(3), ARHGAP4(4), ARHGEF11(23), BTK(15), CDC42(2), CFL1(2), GDI1(2), GDI2(3), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(12), LIMK1(5), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PITX2(6), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(6), ROCK2(14), SAG(11), WASF1(5), WASL(4) 29440830 433 157 409 213 286 35 17 55 39 1 0.0305 1.000 1.000 135 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), CARM1(7), COMT(4), DBH(16), DCT(4), DDC(16), ECH1(5), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(15), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NAT6(5), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SH3GLB1(2), TAT(21), TH(11), TPO(49), TYR(11), TYRP1(9), WBSCR22(2) 25297475 443 156 416 241 306 37 22 36 42 0 0.258 1.000 1.000 136 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(5), AKT1(4), APC(27), CAMP(2), CAV3(2), DAG1(9), DLG4(7), EPHB2(36), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(6), PTX3(1), RHO(2), RYR1(114) 19228527 335 156 323 212 223 30 16 26 38 2 0.434 1.000 1.000 137 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 20812840 354 155 323 161 240 28 20 35 31 0 0.000464 1.000 1.000 138 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 20812840 354 155 323 161 240 28 20 35 31 0 0.000464 1.000 1.000 139 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(3), CREBBP(24), CTBP2(6), DLL1(3), DLL3(7), DLL4(12), DTX1(7), DTX2(2), DTX3(5), DTX3L(6), DTX4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), HDAC1(2), HDAC2(2), HES1(2), JAG1(10), JAG2(10), LFNG(5), MAML1(9), MAML2(7), MAML3(9), MFNG(8), NCOR2(28), NCSTN(5), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), NUMB(4), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(3) 29318409 364 155 360 211 222 41 13 50 38 0 0.908 1.000 1.000 140 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B10(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), XYLB(6) 11594001 380 154 332 146 274 27 14 19 45 1 5.30e-05 1.000 1.000 141 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(36), FBXW7(11), GRAP2(7), GRB2(2), ITK(25), ITPKB(11), LAT(3), LCK(17), LCP2(8), MAPK1(4), NCK1(2), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(9), PTPRC(36), RAF1(12), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), SOS1(10), SOS2(13), VAV1(19), ZAP70(8) 23625534 427 154 407 213 271 33 17 48 55 3 0.215 1.000 1.000 142 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(10), F11(14), F12(1), F13B(35), F2(13), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), LPA(59), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6), SERPINF2(7), VWF(60) 14972071 441 153 419 176 311 27 23 38 40 2 0.00519 1.000 1.000 143 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(7), ATM(16), ATR(22), BAI1(16), BAX(5), CASP3(3), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG1(2), CCNG2(1), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(11), IGFBP3(3), MDM2(4), MDM4(2), PERP(3), PPM1D(4), RFWD2(7), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(10), SERPINE1(6), SESN1(2), SESN2(7), SESN3(1), SFN(2), STEAP3(9), THBS1(31), TNFRSF10B(5), TP53I3(3), TP73(6), TSC2(14), ZMAT3(1) 26708545 317 152 306 171 200 26 17 40 33 1 0.627 1.000 1.000 144 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(4), AKT2(8), AKT3(3), BCR(14), BTK(15), CD19(8), DAPP1(6), FLOT1(2), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(6), PLCG2(30), PPP1R13B(9), PREX1(10), PTPRC(36), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SAG(11), SYK(15), TEC(13), VAV1(19) 22834294 338 152 317 194 217 24 18 37 40 2 0.318 1.000 1.000 145 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(5), CALR(2), CANX(1), CD4(9), CD74(8), CD8A(2), CD8B(9), CIITA(18), CTSS(7), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), HSP90AA1(3), HSP90AB1(8), HSPA5(7), IFI30(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KIR3DL3(5), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LGMN(5), LTA(5), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(14), TAPBP(2) 19638215 363 151 346 217 242 32 14 39 35 1 0.466 1.000 1.000 146 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MIOX(7), OCRL(7), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30) 18985076 398 151 360 174 278 20 17 34 46 3 0.00141 1.000 1.000 147 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCR(14), BLNK(15), BTK(15), CD19(8), CSK(1), DAG1(9), EPHB2(36), GRB2(2), ITPKB(11), LYN(11), MAP2K1(18), MAP2K2(5), MAPK1(4), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), RAF1(12), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 22505137 356 150 335 199 219 28 15 47 44 3 0.644 1.000 1.000 148 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ACAT2(1), ACMSD(13), AFMID(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CARM1(7), CAT(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADH(3), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(10), KMO(8), KYNU(16), LCMT1(4), LCMT2(1), LNX1(20), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NFX1(10), OGDH(10), OGDHL(44), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(2) 25767980 436 149 414 215 290 36 19 47 42 2 0.0345 1.000 1.000 149 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(10), ADAM17(1), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), CASP3(3), CDC42(2), CHUK(2), CSK(1), EGFR(26), F11R(7), GIT1(6), HBEGF(1), IGSF5(12), IKBKB(4), JAM2(11), JAM3(3), JUN(1), LYN(11), MAP2K4(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(3), MAPK9(4), MET(23), NFKB1(6), NFKB2(5), NFKBIA(2), NOD1(10), PAK1(4), PLCG1(9), PLCG2(30), PTPN11(10), PTPRZ1(27), RELA(4), SRC(2), TCIRG1(6), TJP1(16) 29808581 379 149 372 220 226 31 19 52 50 1 0.803 1.000 1.000 150 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAK1(2), BAX(5), BFAR(2), BTK(15), CAD(18), CASP10(10), CASP3(3), CASP8(9), CD7(2), CDK2AP1(2), CSNK1A1(5), DAXX(10), DEDD(2), DEDD2(3), DFFA(2), DIABLO(3), EGFR(26), EPHB2(36), FAF1(9), FAIM2(6), HSPB1(2), IL1A(5), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MET(23), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(17), RALBP1(3), RIPK1(3), ROCK1(6), SMPD1(3), TNFRSF6B(2), TPX2(11), TRAF2(2), TUFM(8) 30548804 376 149 364 219 227 27 19 48 54 1 0.907 1.000 1.000 151 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH4A1(6), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), GAMT(5), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(77), NOS3(20), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), P4HB(3), PYCR1(1), RARS(7), SMS(5) 18768312 349 148 330 182 223 36 17 30 42 1 0.0721 1.000 1.000 152 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), ELK1(3), FPR1(22), GNA15(7), GNB1(1), HRAS(6), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NCF1(3), NCF2(8), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(56), PLCB1(61), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), RELA(4), SYT1(23) 16042826 358 148 320 145 243 27 12 33 42 1 0.00306 1.000 1.000 153 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(10), B4GALT1(2), B4GALT2(3), G6PC(6), G6PC2(3), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), HSD3B7(5), LALBA(8), LCT(54), MGAM(190), PFKL(3), PFKM(2), PFKP(2), PGM1(8), PGM3(1), RDH11(3), RDH12(2), RDH13(3), RDH14(1), UGP2(1) 16418433 390 148 363 221 290 31 9 34 25 1 0.0791 1.000 1.000 154 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(7), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), NOS1(77), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), SYT1(23) 10852964 354 147 331 218 258 29 9 23 33 2 0.225 1.000 1.000 155 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(3), FBP2(2), G6PC(6), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), LALBA(8), LCT(54), MGAM(190), PFKM(2), PFKP(2), PGM1(8), PGM3(1) 13840899 361 146 334 201 269 31 8 30 22 1 0.0655 1.000 1.000 156 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(6), GPD1(10), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), NAT6(5), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10), PTDSS2(3), SH3GLB1(2) 27808795 388 146 366 199 247 32 17 40 49 3 0.171 1.000 1.000 157 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(27), AXIN1(10), CCND1(2), CCND2(7), CCND3(2), CSNK1E(5), CTNNB1(17), DVL1(1), DVL2(3), DVL3(9), FBXW2(2), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LDLR(19), MAPK10(9), MAPK9(4), MYC(5), PAFAH1B1(6), PLAU(3), PPP2R5C(4), PPP2R5E(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), RHOA(3), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6) 25283138 358 146 348 191 223 34 10 38 53 0 0.215 1.000 1.000 158 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ITPA(1), NME1(1), NT5E(7), NT5M(2), NUDT2(2), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), RRM1(3), RRM2(4), TK1(1), TK2(1), TXNRD1(5), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(14), UPP1(1) 24451868 338 145 313 151 214 31 11 51 30 1 0.0137 1.000 1.000 159 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(55), C5(23), C6(72), C7(49), ICAM1(2), IL1A(5), IL6(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELP(38), SELPLG(11), TNF(1), VCAM1(17) 10497617 371 144 336 153 262 12 18 36 38 5 0.000448 1.000 1.000 160 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), COMT(4), DBH(16), DCT(4), DDC(16), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(15), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(21), TH(11), TPO(49), TYR(11) 13462769 357 144 332 197 258 29 15 22 33 0 0.0646 1.000 1.000 161 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPS(5), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CLC(5), CPT1B(9), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), ETNK1(5), GNPAT(1), GPD1(10), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB2(12), PLCG1(9), PLCG2(30), PPAP2A(1), PPAP2B(11), PPAP2C(10) 21257308 365 143 349 181 238 28 12 37 46 4 0.0138 1.000 1.000 162 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(10), AKR1D1(21), ARSB(3), ARSD(3), ARSE(5), CYP11B1(19), CYP11B2(12), HSD11B1(14), HSD11B2(2), HSD17B2(13), HSD17B3(5), HSD3B1(15), HSD3B2(14), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35) 11606136 346 142 311 151 233 36 15 22 38 2 0.000187 1.000 1.000 163 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(56), B3GALT4(2), CDR1(13), DGKI(36), IL6ST(11), MRPL19(1), PIGK(7), RPL10(4), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL22(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(5), RPL5(8), RPL6(1), RPL7(2), RPLP0(1), RPLP2(1), RPS11(1), RPS13(1), RPS15(1), RPS16(2), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(12), TBC1D10C(6), TSPAN9(4), UBB(1), UBC(6) 22127343 290 142 275 165 183 27 15 31 34 0 0.579 1.000 1.000 164 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(15), CALM1(1), CALM2(1), ELK1(3), FCER1A(17), FCER1G(1), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK2(9), PIK3CA(10), PIK3R1(4), PLA2G4A(16), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 18306564 302 141 282 136 186 21 13 41 38 3 0.285 1.000 1.000 165 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(10), ALOX15(11), ALOX5(14), CYP1A2(9), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), HSD3B7(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 10175182 371 141 347 207 271 19 11 19 48 3 0.0279 1.000 1.000 166 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(12), ACADL(5), ACADM(5), ACADSB(6), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), MLYCD(2), SDS(3), SMS(5), UPB1(14) 12394672 282 140 256 115 183 23 10 36 30 0 0.00188 1.000 1.000 167 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(7), CDK4(8), CDKN1B(2), DAZL(5), DMC1(11), EGR1(4), ESR2(10), FSHR(21), GJA4(4), INHA(4), LHCGR(29), MLH1(7), NCOR1(23), NR5A1(10), NRIP1(10), PGR(16), PRLR(38), PTGER2(7), SMPD1(3), VDR(3), ZP2(17) 14868394 259 139 232 136 164 19 9 33 33 1 0.655 1.000 1.000 168 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(9), DUSP4(4), DUSP8(3), GAB1(8), GCK(16), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(5), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK10(9), MAPK7(4), MAPK8(3), MAPK9(4), MYEF2(4), NFATC3(11), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4), ZAK(8) 21081080 320 139 307 166 214 26 8 36 34 2 0.791 1.000 1.000 169 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(27), AXIN1(10), AXIN2(5), CER1(18), CSNK1A1(5), CTNNB1(17), DACT1(13), DKK1(3), DKK2(19), DKK3(4), DKK4(4), DVL1(1), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(47), MVP(13), NKD1(9), NKD2(7), PIN1(1), PSEN1(3), PTPRA(9), SENP2(9), SFRP1(4), TSHB(7), WIF1(7) 17058518 267 138 256 137 158 31 11 30 35 2 0.385 1.000 1.000 170 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(8), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDK5(6), F2(13), FYN(8), GNA11(9), GNAI1(2), GNB1(1), GRB2(2), HRAS(6), JAK2(8), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MAPT(10), MYLK(48), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), SYT1(23) 17667566 291 137 268 166 180 22 13 38 36 2 0.615 1.000 1.000 171 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(8), APOA1(1), APOA2(1), CD36(6), CPT1B(9), CREBBP(24), DUSP1(1), DUT(1), EHHADH(6), EP300(19), FABP1(6), HSD17B4(6), HSPA1A(1), JUN(1), LPL(6), MAPK1(4), MAPK3(3), ME1(22), MRPL11(2), MYC(5), NCOA1(9), NCOR1(23), NCOR2(28), NFKBIA(2), NR0B2(6), NR1H3(5), NR2F1(8), NRIP1(10), PDGFA(1), PIK3CA(10), PIK3R1(4), PPARA(8), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(5), TNF(1) 27018423 327 137 317 165 207 31 22 34 29 4 0.465 1.000 1.000 172 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(4), APC(27), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(26), GNA11(9), GNA15(7), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(4), PITX2(6), PTX3(1), RAF1(12), SRC(2) 21993923 296 137 285 176 185 24 16 34 36 1 0.690 1.000 1.000 173 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(6), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(11), MAPK1(4), MAPK3(3), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PRKAA1(1), PRKAA2(32), RHEB(2), RICTOR(13), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), STK11(4), TSC1(9), TSC2(14), ULK1(11), ULK2(7), ULK3(1), VEGFA(5), VEGFB(3) 21478262 290 136 275 148 174 26 14 39 35 2 0.418 1.000 1.000 174 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GAPDHS(3), GCK(16), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6B(6), LDHB(2), LDHC(7), MDH1(3), MDH2(4), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGK1(3), PGK2(36), PKLR(14), TNFAIP1(2), TPI1(1) 18119057 284 135 267 156 200 21 15 23 25 0 0.0402 1.000 1.000 175 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(66), GABBR1(9), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM7(45), GRM8(50) 8913247 325 135 300 227 233 23 16 24 28 1 0.159 1.000 1.000 176 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(12), ACADM(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(5), SRM(1), UPB1(14) 11529012 257 135 233 110 164 22 11 32 28 0 0.00794 1.000 1.000 177 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(24), ACACB(23), ACAT2(1), ACOT12(15), ACSS1(2), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PCK2(6), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14) 19964758 291 135 278 153 191 19 19 31 30 1 0.210 1.000 1.000 178 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(10), AKR1C4(10), AKR1D1(21), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), HSD3B7(5), LIPA(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SLC27A5(10), SOAT1(3), SOAT2(6), SRD5A1(3) 13517370 287 134 255 123 188 30 22 21 25 1 0.000725 1.000 1.000 179 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(10), AADAC(16), ABAT(12), ACADS(6), ACAT2(1), ACSM1(32), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(8), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADH(3), HADHA(6), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(4), OXCT1(4), OXCT2(5), PDHA1(5), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 17313381 306 134 294 144 208 26 18 23 31 0 0.0246 1.000 1.000 180 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(4), CRK(3), CRKL(2), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(30), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K1(18), MAP2K2(5), MAP4K1(12), MAPK1(4), MAPK3(3), MAPK8(3), MET(23), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAF1(12), RAP1A(1), RAP1B(1), RASA1(5), SOS1(10), SRC(2), STAT3(11) 18275872 267 134 249 138 156 24 10 46 29 2 0.858 1.000 1.000 181 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(4), ATF1(5), CAMP(2), CREB3(1), CREB5(9), CREBBP(24), CRKL(2), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(27), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), NTRK1(16), OPN1LW(8), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN11(10), RPS6KA3(2), SHC1(2), SRC(2), TERF2IP(2), TH(11) 21156942 307 134 290 167 204 25 13 34 30 1 0.590 1.000 1.000 182 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(3), CCR3(11), CFL1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), LIMK1(5), MAP2K1(18), MAPK1(4), MAPK3(3), MYL2(9), NOX1(13), PIK3C2G(56), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2(7), RAF1(12), ROCK2(14) 10668631 283 133 247 94 194 15 7 39 28 0 0.000227 1.000 1.000 183 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C8B(47), C9(22), MASP1(20) 8278889 347 133 313 152 263 15 11 28 26 4 0.00453 1.000 1.000 184 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(27), ATP4A(17), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), COX10(8), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA13(4), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFC2(2), NDUFS1(2), NDUFS2(3), NDUFS3(5), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(1), NDUFV2(1), NDUFV3(5), PPA1(1), PPA2(4), SDHA(4), SDHC(5), SDHD(2), TCIRG1(6), UQCRC1(4), UQCRC2(3), UQCRFS1(3) 23869939 283 132 275 141 163 26 16 45 30 3 0.186 1.000 1.000 185 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GCNT1(6), GCNT3(8), GCNT4(3), OGT(9), ST3GAL1(8), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(46) 13764968 286 132 269 132 194 15 8 33 36 0 0.0787 1.000 1.000 186 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(39), AR(10), ESR1(6), ESR2(10), ESRRA(3), HNF4A(26), NPM1(4), NR0B1(3), NR1D1(1), NR1D2(11), NR1H2(5), NR1H3(5), NR1I2(5), NR1I3(7), NR2C2(1), NR2E1(8), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(10), NR5A2(23), PGR(16), PPARA(8), PPARD(3), PPARG(12), RARA(5), RARB(9), RARG(3), ROR1(15), RORA(8), RORC(15), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3) 17788226 334 132 318 168 232 26 11 26 39 0 0.0451 1.000 1.000 187 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(15), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), MAP2K1(18), MAPK1(4), MAPK3(3), NR1I3(7), PAK1(4), PDE3A(30), PDE3B(6), PI3(6), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), RIPK3(10), VASP(3) 20646859 294 132 267 132 199 23 12 28 31 1 0.00494 1.000 1.000 188 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(8), GRB2(2), HRAS(6), JUN(1), LAT(3), LCK(17), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(4), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PTPN7(4), RAF1(12), RASA1(5), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(8) 20162906 283 132 265 130 174 29 10 36 31 3 0.323 1.000 1.000 189 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(7), BAD(4), BAK1(2), BAX(5), BCL2(3), BCL2L11(8), BIRC2(6), BIRC3(7), BIRC5(3), BNIP3L(1), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), GZMB(4), HELLS(6), IKBKB(4), IRF1(2), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(14), IRF7(5), JUN(1), LTA(5), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(12), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFSF10(10), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5) 24040874 296 131 291 169 189 30 16 29 31 1 0.705 1.000 1.000 190 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22), MASP1(20), MASP2(11), MBL2(14) 8493602 325 131 296 140 249 13 8 25 26 4 0.00350 1.000 1.000 191 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(15), BTK(15), CALM1(1), CALM2(1), CD79A(4), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP3K1(4), MAPK14(5), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 16111141 263 130 244 124 169 17 9 33 33 2 0.355 1.000 1.000 192 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), AMDHD1(6), AOC2(9), AOC3(9), ASPA(3), CARM1(7), CNDP1(10), DDC(16), FTCD(4), HAL(14), HARS(8), HARS2(4), HDC(25), HEMK1(4), HNMT(3), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), PRPS1(3), PRPS2(3), UROC1(17), WBSCR22(2) 16840005 269 130 258 162 165 24 15 27 36 2 0.438 1.000 1.000 193 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(26), ELK1(3), GNAS(33), GNB1(1), GRB2(2), HRAS(6), IGF1R(15), ITGB1(7), KLK2(5), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(30), RAF1(12), RPS6KA1(11), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(11) 14040067 271 128 251 116 165 29 13 43 21 0 0.0501 1.000 1.000 194 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(12), ALOX12(6), ALOX15(11), ALOX5(14), CBR3(1), CYP4F2(17), CYP4F3(26), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(12), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(49) 11883679 330 128 321 182 229 31 5 25 39 1 0.0174 1.000 1.000 195 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(10), OGDHL(44), PIPOX(7), PLOD1(6), PLOD2(7), PLOD3(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SETD1A(27), SETD7(2), SETDB1(10), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2) 24660651 310 127 299 148 202 27 16 39 25 1 0.0714 1.000 1.000 196 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(3), CHUK(2), DAXX(10), EGF(22), EGFR(26), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(6), IKBKB(4), JUN(1), MAP2K1(18), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), NFKB1(6), NFKBIA(2), PPP2CA(1), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), RAF1(12), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 20867948 291 127 275 169 178 25 9 34 45 0 0.725 1.000 1.000 197 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(21), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), SOAT2(6), SRD5A1(3) 9931614 250 126 221 97 169 20 15 22 23 1 0.000181 1.000 1.000 198 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(1), DHX58(3), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), FPGS(3), GGH(4), IFIH1(10), MOV10L1(25), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4) 26610983 279 126 269 157 177 19 17 27 38 1 0.701 1.000 1.000 199 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(7), B3GALNT1(6), B3GALT1(15), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), GBGT1(4), GCNT2(7), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGX(2), PIGZ(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12), UGCG(1) 20326358 257 126 252 141 143 29 12 42 30 1 0.284 1.000 1.000 200 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(4), AKT2(8), AKT3(3), ARHGEF11(23), BCL2(3), CDC42(2), DLG4(7), GNA13(1), LPA(59), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(3), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PI3(6), PIK3CB(10), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RDX(4), ROCK1(6), ROCK2(14), SERPINA4(22), SRF(3), TBXA2R(5) 20876814 273 126 260 152 157 23 11 45 37 0 0.832 1.000 1.000 201 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ARG2(2), ASL(9), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), EPRS(13), GAMT(5), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(2), NOS1(77), NOS3(20), OAT(4), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), PRODH(2), PYCR1(1), PYCR2(1), RARS(7), RARS2(4) 15270113 270 125 256 143 181 26 11 19 31 2 0.162 1.000 1.000 202 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(7), ARRB2(8), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CLCA1(8), CLCA2(9), CLCA4(30), CNGA3(25), CNGA4(18), CNGB1(23), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(11), PDC(6), PDE1C(54), PRKACA(3), PRKACB(4), PRKACG(10), PRKG1(15), PRKG2(16), PRKX(3) 12882005 299 125 279 162 201 24 9 31 34 0 0.133 1.000 1.000 203 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(4), AKT2(8), AKT3(3), BRD4(24), CAP1(2), CBL(10), CDC42(2), F2RL2(8), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), LNPEP(11), MAPK1(4), MAPK3(3), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN1(4), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SERPINB6(5), SFN(2), SHC1(2), SLC2A4(8), SORBS1(16), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 24841631 273 125 266 139 151 34 15 43 29 1 0.599 1.000 1.000 204 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), JUN(1), MAP2K1(18), MAPK3(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RAF1(12), RPS6KA3(2), SYT1(23) 14838618 263 124 241 130 165 26 13 32 26 1 0.365 1.000 1.000 205 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22) 6873265 280 123 253 119 212 11 7 24 22 4 0.00713 1.000 1.000 206 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(7), APAF1(7), ARHGDIB(4), BAG4(3), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), GSN(8), LMNA(5), LMNB1(2), LMNB2(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK8(3), MDM2(4), NFKB1(6), NFKBIA(2), NUMA1(11), PAK2(9), PRKCD(5), PRKDC(22), PSEN1(3), PSEN2(2), PTK2(7), RASA1(5), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2) 29446534 256 123 250 134 123 28 16 48 38 3 0.690 1.000 1.000 207 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(8), ACTN2(21), BCAR1(5), BCR(14), CAPN1(5), CAPNS1(3), CAPNS2(1), CAV1(1), CRKL(2), CSK(1), FYN(8), GRB2(2), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MAPK8(3), PPP1R12B(10), PTK2(7), PXN(2), RAF1(12), RAP1A(1), ROCK1(6), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(9), ZYX(8) 19904213 226 123 213 116 120 27 13 36 29 1 0.378 1.000 1.000 208 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(24), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14) 15779632 244 123 232 119 166 17 13 25 22 1 0.119 1.000 1.000 209 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(6), BCR(14), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K1(18), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8IP3(9), PAPPA(59), RPS6KA1(11), RPS6KA3(2), SHC1(2), SOS1(10), SYK(15), VAV1(19), VAV2(5), VAV3(11) 13394578 232 123 214 147 158 16 4 25 27 2 0.922 1.000 1.000 210 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), ELAVL1(1), FLT1(42), FLT4(31), HIF1A(4), HRAS(6), KDR(57), NOS3(20), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PXN(2), SHC1(2), VHL(4) 14545807 229 121 215 114 149 21 3 29 26 1 0.368 1.000 1.000 211 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(27), ATF2(6), AXIN1(10), BMP10(14), BMP2(7), BMP4(5), BMP5(33), BMP7(5), BMPR1A(2), BMPR2(7), CHRD(21), CTNNB1(17), DVL1(1), FZD1(5), GATA4(5), GSK3B(3), MAP3K7(1), MEF2C(5), MYL2(9), NKX2-5(1), NOG(2), NPPA(5), NPPB(6), RFC1(5), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), WNT1(2) 15445587 233 120 215 103 149 21 10 21 32 0 0.194 1.000 1.000 212 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(7), ENPP7(6), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(3), SMPD2(2), SMPD3(9), SMPD4(6), SPHK1(2), SPHK2(8), SPTLC1(2), SPTLC2(8), UGCG(1), UGT8(8) 15130294 257 120 250 166 178 17 6 30 26 0 0.840 1.000 1.000 213 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), HRH1(15), HRH2(3), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11) 10392292 276 120 252 212 179 32 11 27 25 2 0.0806 1.000 1.000 214 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(48), NCF2(8), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLD1(15), PPP1R12B(10), RALBP1(3), RPS6KB1(4), TRIO(23), VAV1(19), WASF1(5) 14739970 221 120 210 118 138 17 9 27 28 2 0.556 1.000 1.000 215 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(13), F2R(8), F2RL3(5), GNAI1(2), GNB1(1), HRAS(6), ITGA1(23), ITGB1(7), MAP2K1(18), MAPK1(4), MAPK3(3), PLA2G4A(16), PLCB1(61), PRKCA(9), PTGS1(20), PTK2(7), RAF1(12), SRC(2), SYK(15), TBXAS1(16) 10372786 248 120 225 102 164 19 7 30 27 1 0.0135 1.000 1.000 216 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(19), CALCR(19), CALCRL(19), CD97(7), CRHR1(9), CRHR2(5), ELTD1(27), EMR1(35), EMR2(6), GHRHR(12), GIPR(4), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(50), LPHN3(24), SCTR(8), VIPR1(8), VIPR2(7) 11248894 298 119 277 181 213 21 9 16 39 0 0.101 1.000 1.000 217 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(5), GHR(43), GRB2(2), HRAS(6), INSR(23), IRS1(5), JAK2(8), MAP2K1(18), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTPN6(5), RAF1(12), RPS6KA1(11), SHC1(2), SLC2A4(8), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(5) 14139891 209 118 190 99 128 17 12 29 22 1 0.203 1.000 1.000 218 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(12), ACAA1(6), ACAA2(1), ACADM(5), ACADS(6), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), AOX1(29), AUH(2), BCAT1(13), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HADHB(6), HIBADH(5), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), OXCT2(5), PCCA(5), PCCB(3) 18392272 237 118 227 111 154 20 14 25 24 0 0.220 1.000 1.000 219 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(3), FUCA1(3), GALNS(5), GBA(7), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NAGLU(4), NEU1(6), NEU2(19), NEU3(5), NEU4(16), SPAM1(28) 14580267 254 118 249 133 178 22 5 25 23 1 0.184 1.000 1.000 220 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(3), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(12), ARHGEF1(2), ARHGEF11(23), ARHGEF5(17), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), BAIAP2(8), CFL1(2), DIAPH1(10), GSN(8), LIMK1(5), MYL2(9), MYLK(48), OPHN1(4), PIP5K1A(7), PIP5K1B(21), PPP1R12B(10), ROCK1(6), SRC(2), TLN1(12), VCL(9) 19184854 249 118 239 123 175 14 10 25 25 0 0.0772 1.000 1.000 221 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(13), DIAPH1(10), FYN(8), GSN(8), HRAS(6), ITGA1(23), ITGB1(7), MAP2K1(18), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PIK3CA(10), PIK3R1(4), PTK2(7), PXN(2), RAF1(12), ROCK1(6), SHC1(2), SRC(2), TLN1(12) 15890305 214 117 193 98 132 16 8 34 23 1 0.237 1.000 1.000 222 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(6), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), RFT1(5), RPN2(4), ST6GAL1(8), STT3B(5) 18038343 210 117 203 110 124 22 14 22 27 1 0.257 1.000 1.000 223 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(2), BLVRB(1), CP(14), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UROS(1) 11766354 231 117 209 104 158 20 12 15 24 2 0.0382 1.000 1.000 224 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(10), EGF(22), EGFR(26), GRB2(2), HRAS(6), MAP2K1(18), MAPK1(4), MAPK3(3), PTPRB(97), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), SRC(2) 10643027 246 117 221 106 164 21 6 28 27 0 0.172 1.000 1.000 225 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(6), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), PPARA(8), RELA(4), TIRAP(1), TLR10(13), TLR2(15), TLR3(11), TLR4(42), TLR6(7), TLR7(17), TLR9(18), TOLLIP(1), TRAF6(4) 15464628 209 117 202 102 138 19 9 23 20 0 0.161 1.000 1.000 226 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(55), C5(23), C6(72), C7(49), C9(22) 4796342 221 115 195 88 165 6 6 21 19 4 0.0108 1.000 1.000 227 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 AGXT(12), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), ATP6V0C(3), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(9), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), MAOA(4), MAOB(13), PEMT(3), PISD(2), PLCB2(12), PLCG1(9), PLCG2(30), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5) 17475585 249 115 242 154 167 19 12 19 32 0 0.467 1.000 1.000 228 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(27), AXIN1(10), CCND1(2), CD14(6), CTNNB1(17), DVL1(1), FZD1(5), GJA1(10), GNAI1(2), GSK3B(3), IRAK1(5), LBP(10), LEF1(4), LY96(4), MYD88(4), NFKB1(6), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4), TIRAP(1), TLR4(42), TOLLIP(1), WNT1(2) 12985566 190 115 181 100 115 17 11 24 21 2 0.717 1.000 1.000 229 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(7), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(14), EDN1(9), EDNRA(12), EDNRB(7), HPGD(2), HSD11B1(14), HSD11B2(2), PLA2G4A(16), PRL(3), PTGDR(12), PTGDS(4), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), PTGIS(18), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16) 8729408 222 115 213 87 151 23 6 20 21 1 4.59e-05 1.000 1.000 230 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(5), CRK(3), CXCL12(8), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(6), MAP2K1(18), MAPK1(4), MAPK3(3), NFKB1(6), PIK3C2G(56), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PTK2B(12), PXN(2), RAF1(12), RELA(4) 11701273 190 114 165 100 125 13 6 29 16 1 0.542 1.000 1.000 231 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(5), AARS2(3), ABAT(12), ACY3(4), ADSL(6), ADSS(2), ADSSL1(9), AGXT(12), ASL(9), ASNS(9), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(9), DLAT(4), DLD(3), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(5), PDHA2(20), PDHB(1) 15732636 223 114 215 124 150 22 12 18 21 0 0.304 1.000 1.000 232 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(12), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CYP2C19(40), CYP2C9(41), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 13220609 199 113 187 118 124 21 14 18 22 0 0.791 1.000 1.000 233 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(5), AARS2(3), CARS(9), CARS2(4), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(8), HARS2(4), IARS(10), IARS2(18), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(4), SARS(5), SARS2(3), TARS(5), TARS2(8), VARS(16), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2) 23310231 227 113 215 126 133 25 9 26 32 2 0.700 1.000 1.000 234 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFAT5(11), PDE6A(15), PDE6B(16), PDE6C(25), PDE6D(2), PDE6G(2), SLC6A13(31), TF(16) 15180327 230 113 215 135 158 11 6 19 36 0 0.184 1.000 1.000 235 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(26), ELK1(3), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PAK1(4), PRKCA(9), PTK2(7), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23) 14071241 209 112 190 119 131 18 10 29 20 1 0.870 1.000 1.000 236 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(25), CD2(29), CD33(21), CD5(8), CD7(2), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(25), TLR2(15), TLR4(42), TLR7(17), TLR9(18) 7912106 234 112 217 116 166 21 11 14 22 0 0.000181 1.000 1.000 237 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(5), CAPN2(6), CAPNS1(3), CAPNS2(1), CXCR3(4), EGF(22), EGFR(26), HRAS(6), ITGA1(23), ITGB1(7), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12) 13847150 219 112 210 129 143 14 10 22 30 0 0.552 1.000 1.000 238 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35) 7546020 191 112 166 93 136 17 11 8 18 1 0.0536 1.000 1.000 239 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TAT(21), TPO(49) 9341657 214 112 208 146 148 22 7 12 25 0 0.531 1.000 1.000 240 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(15), DLG4(7), EPHB2(36), F2(13), F2RL1(9), F2RL2(8), F2RL3(5), JUN(1), MAP2K5(5), MAPK1(4), MAPK7(4), MAPK8(3), MYEF2(4), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RAF1(12), RASAL1(18), SRC(2), TEC(13), VAV1(19) 11671726 209 112 201 142 123 23 6 31 23 3 0.959 1.000 1.000 241 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), AOX1(29), BCAT1(13), BCKDHA(1), BCKDHB(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), HIBADH(5), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), PCCA(5), PCCB(3), SDS(3) 15396124 206 112 196 97 135 16 10 22 23 0 0.234 1.000 1.000 242 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(11), ITGB3(25), MAPK1(4), MAPK3(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCB1(61), PRKCA(9), PTK2(7), SMPD1(3), SMPD2(2), SPHK1(2), SRC(2) 11555407 217 111 207 87 150 13 8 24 21 1 0.00491 1.000 1.000 243 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(12), ACACA(24), ACACB(23), ACADM(5), ACAT2(1), ACSS1(2), ACSS2(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SUCLG1(4), SUCLG2(3) 16979753 193 111 185 103 115 15 17 23 23 0 0.499 1.000 1.000 244 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), AOC2(9), AOC3(9), ASPA(3), CNDP1(10), DDC(16), HAL(14), HARS(8), HDC(25), HNMT(3), MAOA(4), MAOB(13), PRPS1(3), PRPS2(3) 10368931 194 110 183 111 119 14 10 20 30 1 0.289 1.000 1.000 245 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), NAT6(5), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(21), TPO(49) 14603732 224 110 218 158 154 21 11 14 24 0 0.952 1.000 1.000 246 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(37), ACE2(6), AGT(8), AGTR1(10), AGTR2(10), ANPEP(25), CMA1(6), CPA3(23), CTSA(4), CTSG(5), ENPEP(46), LNPEP(11), MAS1(4), MME(25), NLN(5), REN(12), THOP1(6) 8991146 243 110 227 124 169 20 11 14 28 1 0.0266 1.000 1.000 247 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), SELE(33), SELL(12), SELP(38) 6733714 211 110 199 83 153 7 6 18 25 2 0.00690 1.000 1.000 248 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(10), IL13RA1(4), IL2RG(3), IL4(1), IL4R(18), INPP5D(39), JAK1(7), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(4), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(9), TYK2(9) 15692547 224 110 213 108 146 17 9 29 22 1 0.338 1.000 1.000 249 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(34), AKT1(4), BAD(4), BAX(5), BCL2(3), CSF2RB(25), IGF1(11), IGF1R(15), IL3(3), IL3RA(8), KIT(13), KITLG(10), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 9343573 176 109 168 103 111 19 11 16 18 1 0.521 1.000 1.000 250 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(4), BAD(4), BCL2(3), CBL(10), CFLAR(5), CRKL(2), E2F1(6), FOS(2), GRB2(2), HRAS(6), IL2RA(7), IL2RB(12), IL2RG(3), IRS1(5), JAK1(7), JAK3(11), MAPK1(4), MAPK3(3), MYC(5), NMI(4), PIK3CA(10), PIK3R1(4), PPIA(1), PTPN6(5), RAF1(12), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 15355772 178 109 173 104 100 22 11 24 20 1 0.847 1.000 1.000 251 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(16), CARM1(7), CCND1(2), CREBBP(24), EP300(19), ERCC3(6), ESR1(6), GRIP1(13), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), MEF2C(5), NCOR2(28), NR0B1(3), NRIP1(10), PELP1(14), POLR2A(14), TBP(4) 19402795 210 108 207 92 134 12 12 34 18 0 0.175 1.000 1.000 252 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), ADC(5), AGMAT(4), ALDH18A1(8), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), ASS1(8), CPS1(29), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(5), SRM(1) 12448901 174 108 168 94 96 17 10 23 28 0 0.345 1.000 1.000 253 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(7), ACTG2(6), ADCY3(3), ADCY9(11), AK1(1), ARF4(3), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(33), PDIA4(5), PLCG1(9), PLCG2(30), PRKCA(9), SEC61A1(3), SEC61A2(2), TRIM23(2) 15808781 216 108 208 128 142 12 10 24 28 0 0.443 1.000 1.000 254 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(6), CDC42(2), DAXX(10), DDIT3(3), ELK1(3), GRB2(2), HMGN1(3), HRAS(6), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MYC(5), PLA2G4A(16), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2) 15328745 186 108 181 75 115 16 7 26 22 0 0.117 1.000 1.000 255 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(53), CR2(36), FCGR2B(3), HLA-DRA(13), HLA-DRB1(5), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36) 6426148 196 107 186 78 127 15 7 15 27 5 0.0269 1.000 1.000 256 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(26), EEF1A2(10), EEF1B2(1), EEF1D(7), EEF1G(6), EEF2(3), EEF2K(6), EIF1AX(3), EIF1AY(1), EIF2AK1(4), EIF2AK2(6), EIF2AK3(13), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G3(19), EIF5(2), EIF5B(4), ETF1(2), GSPT2(9), PABPC1(5), PABPC3(8), PAIP1(9), SLC35A4(4) 18614061 187 107 186 95 107 24 13 19 24 0 0.675 1.000 1.000 257 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(12), STON1(22), TAF1(15), TAF13(1), TAF1L(57), TAF2(9), TAF4(11), TAF4B(7), TAF5L(4), TAF6(4), TAF6L(4), TAF7(3), TAF7L(12), TAF9(3), TAF9B(1), TBPL1(1), TBPL2(8) 15433182 206 106 201 90 140 14 8 25 19 0 0.280 1.000 1.000 258 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(27), ATP4B(1), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(13), ATP7B(23), COX10(8), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1), PPA2(4), SDHA(4), SHMT1(2), UQCRC1(4), UQCRFS1(3) 16344614 198 106 196 119 116 12 18 29 21 2 0.800 1.000 1.000 259 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(27), AXIN1(10), CREBBP(24), CTNNB1(17), DVL1(1), EP300(19), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(4), PITX2(6), TRRAP(47), WNT1(2) 14184657 170 106 164 93 91 16 13 24 25 1 0.890 1.000 1.000 260 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(12), ACACA(24), ACADL(5), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), LDHA(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SDS(3), SUCLG1(4), SUCLG2(3) 14168861 177 106 169 79 112 13 12 23 17 0 0.164 1.000 1.000 261 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(4), AKT2(8), AKT3(3), BAD(4), BTK(15), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(10), IGFBP1(3), INPP5D(39), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 14749762 192 106 179 83 121 16 11 25 18 1 0.211 1.000 1.000 262 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(12), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(3), PHGDH(5), PIPOX(7), PISD(2), PSAT1(4), PSPH(2), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SARDH(20), SARS(5), SARS2(3), SDS(3), SHMT1(2), SHMT2(3), TARS(5), TARS2(8) 17771881 241 105 235 150 165 18 10 15 33 0 0.553 1.000 1.000 263 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(4), BAX(5), BCL2(3), BCL2A1(2), BCL2L2(3), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(1), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKE(9), LTA(5), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(17), RIPK1(3), TFG(1), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4) 18464851 204 104 201 131 127 19 9 24 24 1 0.972 1.000 1.000 264 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(10), ABAT(12), ACADS(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(20), PDHB(1), SDS(3) 11044883 181 104 172 74 116 17 7 20 21 0 0.00967 1.000 1.000 265 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CMBL(5), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), PON1(15), PON2(3), PON3(6) 7664834 202 104 191 75 145 12 6 12 26 1 3.57e-05 1.000 1.000 266 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), CAMP(2), CASP3(3), CERK(1), CREB3(1), CREB5(9), DAG1(9), EPHB2(36), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4) 12137477 163 104 158 98 106 11 8 16 21 1 0.862 1.000 1.000 267 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), ATF1(5), CDC42(2), CREB3(1), CREB5(9), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(13), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(7), MKNK2(4), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4) 14189558 177 104 170 102 113 17 3 23 21 0 0.719 1.000 1.000 268 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(13), BCAT2(1), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), ILVBL(5), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14), VNN1(7) 7364067 196 103 174 56 143 11 3 21 18 0 4.84e-06 1.000 1.000 269 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 218 102 208 104 140 22 11 21 23 1 0.114 1.000 1.000 270 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 218 102 208 104 140 22 11 21 23 1 0.114 1.000 1.000 271 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(22), EGFR(26), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 15968694 186 102 174 94 104 18 8 33 22 1 0.769 1.000 1.000 272 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(4), AVP(1), CABIN1(17), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), HDAC5(6), IGF1(11), IGF1R(15), INSR(23), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1), NFATC1(18), NFATC2(12), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(23) 14860672 204 102 192 111 134 19 10 23 17 1 0.371 1.000 1.000 273 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), GLCE(8), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(51) 8709189 176 102 171 96 112 13 8 20 23 0 0.238 1.000 1.000 274 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ATP6V0C(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADHA(6), PLOD1(6), PLOD2(7), PLOD3(5), SDS(3), SHMT1(2), SHMT2(3), TMLHE(2) 15709863 176 102 168 91 113 18 7 21 16 1 0.220 1.000 1.000 275 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(34), ARHGEF1(2), F2(13), F2R(8), F2RL3(5), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(4), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2B(12), ROCK1(6) 11017213 188 102 177 91 124 15 8 23 16 2 0.181 1.000 1.000 276 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), PAK1(4), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23) 11951296 162 102 145 90 95 15 8 25 19 0 0.782 1.000 1.000 277 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(3), CDK2(1), CDT1(3), DIAPH2(9), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), NACA(44), PCNA(2), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(3), RFC1(5), RFC2(4), RFC3(1), RPA1(3), RPA2(2), RPA4(2), UBB(1), UBC(6) 21570075 180 101 177 112 122 13 7 25 13 0 0.889 1.000 1.000 278 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), GNAS(33), GRB2(2), HRAS(6), MAPK1(4), MAPK14(5), MAPK3(3), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RPS6KA1(11), RPS6KA5(7), SOS1(10) 12178266 193 100 186 107 123 20 9 19 21 1 0.703 1.000 1.000 279 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(12), ACO1(8), ACO2(5), CLYBL(5), CS(2), DLD(3), DLST(1), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), OGDHL(44), PC(14), PCK1(28), PCK2(6), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3) 12781489 190 100 172 91 127 7 7 27 22 0 0.0730 1.000 1.000 280 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(10), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), FUK(8), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), HSD3B7(5), KHK(2), LHPP(1), MPI(2), MTMR1(6), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(6), PFKFB3(5), PFKFB4(8), PFKL(3), PFKM(2), PFKP(2), PGM2(7), PMM1(4), PMM2(3), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SORD(2), TPI1(1), TSTA3(4) 15743248 172 100 167 122 109 15 14 18 16 0 0.826 1.000 1.000 281 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3) 5638748 148 100 128 47 106 10 11 11 10 0 7.06e-05 1.000 1.000 282 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL1RN(8), IL6(2), IRAK1(5), IRAK2(15), IRAK3(11), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 12575253 139 100 134 78 88 12 4 15 20 0 0.581 1.000 1.000 283 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(15), ABCC2(12), ABCG2(5), BCHE(7), CES1(21), CES2(4), CYP3A4(21), CYP3A5(14), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16) 9767425 208 100 188 90 141 17 11 17 20 2 0.00128 1.000 1.000 284 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 14868996 171 100 159 75 94 17 7 34 18 1 0.366 1.000 1.000 285 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(10), F2(13), F2R(8), F3(2), F5(39), F7(7), FGA(42), FGB(10), FGG(10), PROC(11), PROS1(17), SERPINC1(7), TFPI(8) 6998214 184 99 170 72 124 19 8 19 13 1 0.0485 1.000 1.000 286 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(12), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EARS2(2), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GFPT2(9), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSR(2), GSS(9), NADSYN1(4), NAGK(1), QARS(6) 16849083 198 99 191 112 114 24 11 28 20 1 0.611 1.000 1.000 287 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(3), CREBBP(24), EP300(19), FYN(8), IL2RG(3), IL7(5), IL7R(37), JAK1(7), JAK3(11), LCK(17), NMI(4), PIK3CA(10), PIK3R1(4), PTK2B(12), STAT5A(3), STAT5B(5) 11900062 172 99 167 86 103 20 8 23 16 2 0.470 1.000 1.000 288 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(13), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14) 5933233 183 99 161 51 131 11 3 21 17 0 3.53e-05 1.000 1.000 289 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(7), BAK1(2), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(5), FASLG(15), GZMB(4), JUN(1), MAP2K4(4), MAP3K1(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), PARP1(8), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(10), TRAF1(6), TRAF2(2) 15536074 168 98 166 80 98 18 11 19 22 0 0.306 1.000 1.000 290 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(26), F2(13), F2R(8), FGA(42), FGB(10), FGG(10), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6) 5693092 180 98 171 69 126 12 10 18 13 1 0.0350 1.000 1.000 291 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(16), ATR(22), BRCA1(16), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(4), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(19), MDM2(4), MYT1(21), PRKDC(22), RPS6KA1(11), WEE1(2), YWHAQ(3) 17533576 164 98 161 76 100 14 8 29 13 0 0.638 1.000 1.000 292 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME3(8), PGK1(3), PGK2(36), PKLR(14), TKT(6), TKTL1(3), TKTL2(28), TPI1(1) 8638255 170 98 157 95 124 17 5 13 10 1 0.0732 1.000 1.000 293 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PIK3CB(10), PITX2(6), PLD1(15), PLD2(8), PLD3(1), VN1R1(1) 19078956 184 98 176 124 104 16 13 28 23 0 0.868 1.000 1.000 294 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(20), FOS(2), HRAS(6), JUN(1), MAP2K1(18), MAPK1(4), MAPK3(3), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RAF1(12), RELA(4), TNF(1) 6642738 154 97 133 58 106 10 7 16 15 0 0.00314 1.000 1.000 295 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(9), CHAT(20), COMT(4), DBH(16), DDC(16), GAD1(14), GAD2(9), HDC(25), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(11), TPH1(12) 6036350 159 95 150 98 113 14 6 6 19 1 0.221 1.000 1.000 296 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(8), AZIN1(1), BTG1(5), CBX3(2), CLOCK(4), CRY1(7), CRY2(7), EIF4G2(6), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(15), NCKAP1(5), NCOA4(4), NR1D2(11), PER1(8), PER2(12), PIGF(3), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(2), SF3A3(7), SUMO3(2), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(10) 15560924 181 95 178 81 93 18 16 33 21 0 0.530 1.000 1.000 297 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), GHR(43), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(3), MKNK1(7), PABPC1(5), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PRKCA(9), RPS6KB1(4) 11724819 164 95 154 61 98 22 8 16 19 1 0.0467 1.000 1.000 298 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(3), ARSD(3), ARSE(5), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SMPD1(3), SMPD2(2), SPTLC1(2), SPTLC2(8), UGCG(1) 10226157 182 95 177 111 122 15 3 22 20 0 0.773 1.000 1.000 299 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), BTRC(4), CDC20(1), CDC23(4), CDC27(14), CUL1(3), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(8), ITCH(9), SKP2(3), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(7), WWP2(9) 16992013 161 95 156 75 102 8 8 19 23 1 0.692 1.000 1.000 300 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(7), BAIAP2(8), CASP1(4), CASP3(3), CASP7(4), CASP8(9), GAPDH(3), INSR(23), ITCH(9), MAGI1(38), MAGI2(24), RERE(25), WWP1(7), WWP2(9) 10275967 173 94 168 76 115 12 7 17 21 1 0.221 1.000 1.000 301 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(5), HLA-A(4), IL18(3), ITGB1(7), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LAT(3), MAP2K1(18), MAPK3(3), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2B(12), PTPN6(5), SYK(15), VAV1(19) 7727189 141 94 126 87 94 7 4 15 19 2 0.914 1.000 1.000 302 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(34), ADRB2(4), GNAS(33), PLCE1(60), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6249260 158 94 151 80 104 17 10 14 13 0 0.297 1.000 1.000 303 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(10), PDE1A(44), PDE1B(15), PLCB1(61), PLCB2(12), PRL(3), TRH(4), VIP(5) 4695304 160 94 140 66 122 5 2 14 17 0 0.00256 1.000 1.000 304 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK5(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(10), PIK3CD(8), PIK3R1(4), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 14273666 154 94 148 104 103 11 7 19 13 1 0.880 1.000 1.000 305 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), GSR(2), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(2), OPLAH(13), TXNDC12(1) 9340327 180 93 160 94 118 13 7 25 17 0 0.0472 1.000 1.000 306 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(5), BAD(4), CREB3(1), CREB5(9), DUSP4(4), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MOS(6), NFKB1(6), RAP1A(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), SHC1(2), SOS1(10), SOS2(13), TRAF3(5) 11899161 139 93 128 88 93 12 4 17 13 0 0.952 1.000 1.000 307 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(4), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CFLAR(5), DAXX(10), DFFA(2), DFFB(2), FAF1(9), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), PTPN13(17), RB1(10), RIPK2(3), SPTAN1(10) 17418966 157 92 156 84 71 15 13 32 24 2 0.910 1.000 1.000 308 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELE(33), SELL(12) 5121911 148 92 142 57 105 6 5 12 18 2 0.0296 1.000 1.000 309 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(34), CAP1(2), CDC25C(5), GNAI1(2), GNAS(33), GNB1(1), HRAS(6), MAPK1(4), MAPK3(3), MYT1(21), PIN1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(11), SRC(2) 8761289 156 92 150 95 105 16 8 13 14 0 0.614 1.000 1.000 310 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(13), ARHGEF1(2), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(48), PLCB1(61), PPP1R12B(10), PRKCA(9), ROCK1(6) 8853425 169 92 151 73 123 2 7 19 18 0 0.0829 1.000 1.000 311 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), GRB2(2), GSK3A(1), GSK3B(3), IL4R(18), IRS1(5), IRS2(3), JAK1(7), JAK3(11), MAP4K1(12), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PPP1R13B(9), RAF1(12), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(9) 15586079 171 92 169 87 95 25 7 26 17 1 0.532 1.000 1.000 312 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(34), ADRB2(4), CFTR(62), GNAS(33), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2) 5542558 162 91 150 90 108 14 7 14 18 1 0.448 1.000 1.000 313 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BCL2(3), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(14), LMNA(5), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(5), TNFRSF25(6), TNFSF10(10), TNFSF12(1), TRAF2(2) 14242218 138 91 136 78 77 18 10 20 13 0 0.722 1.000 1.000 314 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), NAGLU(4), SPAM1(28) 8678408 160 91 156 96 115 11 3 15 16 0 0.653 1.000 1.000 315 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(9), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(18), IL5(4), TGFB1(2), TGFB2(4), TGFB3(3) 8508318 175 91 164 95 128 12 2 14 19 0 0.0299 1.000 1.000 316 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(6), CDK5R1(1), DAB1(48), FYN(8), LRP8(3), RELN(90), VLDLR(5) 5963173 161 91 154 89 114 9 3 16 18 1 0.888 1.000 1.000 317 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(22), EPHB1(31), FYN(8), ITGA1(23), ITGB1(7), L1CAM(11), LYN(11), RAP1B(1), SELP(38) 6728695 156 90 144 78 108 8 5 18 16 1 0.300 1.000 1.000 318 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(15), ATM(16), ATR(22), CCNA1(16), CCND1(2), CCNE1(4), CDC25A(8), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CDKN1B(2), DHFR(1), E2F1(6), GSK3B(3), HDAC1(2), RB1(10), SKP2(3), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3) 12244144 135 89 130 62 73 9 11 22 18 2 0.486 1.000 1.000 319 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(12), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GLS(2), GLS2(3), GLUD1(2), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSS(9), NADSYN1(4), QARS(6) 14165629 175 89 168 91 101 19 10 26 18 1 0.465 1.000 1.000 320 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL2(4), IL2RA(7), IL2RB(12), IL2RG(3), JAK1(7), JAK3(11), JUN(1), LCK(17), MAP2K1(18), MAPK3(3), MAPK8(3), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 9830354 148 89 136 73 90 13 6 23 16 0 0.313 1.000 1.000 321 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(4), BCL2(3), EGFR(26), IGF1R(15), MYC(5), POLR2A(14), PPP2CA(1), PRKCA(9), RB1(10), TEP1(36), TERF1(2), TERT(10), TNKS(10), XRCC5(2) 11652428 147 89 143 87 85 15 9 17 19 2 0.720 1.000 1.000 322 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 10680233 143 88 126 61 106 9 9 12 7 0 0.132 1.000 1.000 323 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GCNT1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), WBSCR17(46) 6180311 140 88 129 62 98 10 4 13 15 0 0.0629 1.000 1.000 324 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(18), NFATC2(12), NFKB1(6), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7) 11897942 152 88 145 93 97 12 8 17 18 0 0.878 1.000 1.000 325 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(22), BRCA1(16), BRCA2(24), CHEK1(2), CHEK2(2), FANCA(8), FANCC(2), FANCD2(16), FANCE(4), FANCG(7), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(6), RAD9A(6), TREX1(1) 18449843 148 87 145 74 97 7 5 18 21 0 0.862 1.000 1.000 326 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(11), AGT(8), AGTR2(10), EDN1(9), EDNRA(12), EDNRB(7), EGF(22), EGFR(26), FOS(2), HRAS(6), JUN(1), MYC(5), NFKB1(6), PLCG1(9), PRKCA(9), RELA(4) 8756081 147 87 144 77 100 10 8 13 15 1 0.278 1.000 1.000 327 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(10), CSF1R(13), EGF(22), EGFR(26), GRB2(2), MET(23), PDGFRA(32), PRKCA(9), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2) 8308320 148 87 146 91 97 9 5 18 19 0 0.890 1.000 1.000 328 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(12), CSF1R(13), DDX20(11), E2F1(6), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(6), JUN(1), NCOR2(28), RBL1(14), RBL2(6), SIN3A(11), SIN3B(8) 11072204 144 87 143 81 94 7 3 27 13 0 0.591 1.000 1.000 329 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(15), IDH2(2), MGST1(2), MGST2(2), MGST3(2), PGD(9) 7699562 146 87 129 69 91 11 7 22 15 0 0.0264 1.000 1.000 330 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(10), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(5), CSNK1D(3), CSNK2A1(2), CTNNB1(17), DVL1(1), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2) 12450768 133 87 130 73 66 11 12 20 24 0 0.926 1.000 1.000 331 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(4), BCL2(3), BCR(14), CRKL(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), MYC(5), PIK3CA(10), PIK3R1(4), RAF1(12), SOS1(10), STAT1(5), STAT5A(3), STAT5B(5) 11932026 128 86 117 58 67 15 8 20 17 1 0.440 1.000 1.000 332 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16) 8660488 160 86 157 82 116 16 2 14 11 1 0.173 1.000 1.000 333 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(2), ENPP6(14), PAFAH1B1(6), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PPAP2A(1), PPAP2B(11), PPAP2C(10) 9935487 168 86 162 86 104 13 5 22 22 2 0.291 1.000 1.000 334 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(1), POLR3K(1), TAF13(1), TAF6(4), TAF7(3), TAF9(3), TBP(4) 14984109 135 86 131 62 79 12 9 22 13 0 0.384 1.000 1.000 335 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(16), GRM1(13), PLCB1(61), PPP1CA(3), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6801342 147 85 138 94 108 4 6 13 15 1 0.624 1.000 1.000 336 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(3), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(4), TKT(6), TKTL1(3), TKTL2(28) 10337668 132 85 124 91 84 12 7 12 17 0 0.645 1.000 1.000 337 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(9), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(8), POLG2(7), POLH(4), POLI(2), POLK(7), POLL(10), POLM(2), POLQ(26), PRIM1(3), PRIM2(6), REV1(3), REV3L(18) 17244921 143 85 142 70 78 11 11 26 17 0 0.730 1.000 1.000 338 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(32), GSTP1(3) 6071115 159 85 147 75 106 17 5 12 18 1 0.00188 1.000 1.000 339 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PPARA(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(23) 8558172 136 85 129 78 96 9 5 12 14 0 0.372 1.000 1.000 340 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(10), CHIT1(12), CMAS(2), CTBS(6), CYB5R1(1), CYB5R3(2), GFPT1(6), GFPT2(9), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), NPL(2), PGM3(1), RENBP(3), UAP1(2) 12220567 122 84 120 81 75 10 6 19 12 0 0.940 1.000 1.000 341 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(24), DUSP1(1), EP300(19), IKBKB(4), IL1B(8), MAP2K3(9), MAP2K6(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(4), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1) 12666350 125 84 124 78 74 18 5 17 11 0 0.953 1.000 1.000 342 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(5), ABAT(12), ADSL(6), ADSS(2), AGXT(12), ASL(9), ASNS(9), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(9), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), PC(14) 10723068 151 83 147 92 102 16 8 12 13 0 0.429 1.000 1.000 343 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(34), GNAS(33), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6526432 144 83 137 66 97 14 8 9 16 0 0.172 1.000 1.000 344 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(4), BAG4(3), CASP2(1), CASP3(3), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MADD(18), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2) 16569459 133 83 131 71 64 10 13 22 20 4 0.751 1.000 1.000 345 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAPK3(3), MPL(9), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), THPO(10) 12747108 146 83 134 68 81 13 8 28 14 2 0.631 1.000 1.000 346 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(22), EGFR(26), MAP2K1(18), MAP3K1(4), MAPK14(5), NCOR2(28), RARA(5), RXRA(4), THRA(2), THRB(18) 7319734 132 82 121 65 91 11 3 13 14 0 0.282 1.000 1.000 347 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(10), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPHN(9), SRC(2), UBQLN1(5) 5015372 137 82 120 77 100 6 5 14 10 2 0.507 1.000 1.000 348 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), INSR(23), IRS1(5), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SLC2A4(8), SOS1(10), SRF(3) 10916626 132 82 119 61 63 18 6 31 13 1 0.635 1.000 1.000 349 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(27), CDH1(6), CREBBP(24), EP300(19), MAP2K1(18), MAP3K7(1), MAPK3(3), SKIL(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9) 10979411 119 82 110 56 64 14 7 18 16 0 0.791 1.000 1.000 350 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), GCK(16), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), KHK(2), MPI(2), PFKFB1(4), PFKFB3(5), PFKFB4(8), PFKM(2), PFKP(2), PMM1(4), PMM2(3), SORD(2), TPI1(1) 10151370 124 81 119 96 81 13 8 10 12 0 0.829 1.000 1.000 351 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(33), GNB1(1), NFKB1(6), NOS3(20), NPPA(5), NR3C1(7), PIK3CA(10), PIK3R1(4), RELA(4), SYT1(23) 7604428 130 81 121 58 89 13 5 18 4 1 0.282 1.000 1.000 352 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IGF1(11), IGF1R(15), IRS1(5), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3) 10568116 127 81 112 55 64 20 3 28 11 1 0.492 1.000 1.000 353 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(2), GLI2(44), GLI3(19), GSK3B(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(3) 7088275 117 81 114 79 80 11 5 12 9 0 0.867 1.000 1.000 354 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(37), AGT(8), AGTR1(10), AGTR2(10), BDKRB2(10), KNG1(15), NOS3(20), REN(12) 4227401 122 80 117 73 81 8 6 10 15 2 0.141 1.000 1.000 355 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(27), PGAP1(9), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGW(1), PIGX(2), PIGZ(4) 10175297 127 80 124 56 72 9 7 27 12 0 0.0784 1.000 1.000 356 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(29), BST1(2), CD38(6), ENPP1(13), ENPP3(15), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(7), NMNAT3(11), NNMT(11), NNT(4), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT12(5), QPRT(6) 9184446 160 80 152 72 103 11 6 18 22 0 0.130 1.000 1.000 357 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(9), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), HAL(14) 8995302 135 80 130 71 93 10 5 16 11 0 0.473 1.000 1.000 358 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(3), STAT4(26), TYK2(9) 7913073 139 80 134 65 97 8 4 12 18 0 0.226 1.000 1.000 359 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(25), FOS(2), GRB2(2), HRAS(6), IL3(3), IL3RA(8), JAK2(8), MAP2K1(18), MAPK3(3), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 7495921 112 80 101 51 66 7 6 15 18 0 0.249 1.000 1.000 360 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(4), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), PC(14), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(6), PDK4(8), PDP2(5), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3) 12129700 129 80 126 64 82 7 8 15 17 0 0.344 1.000 1.000 361 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4B(6), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), MKNK1(7), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4), TSC1(9), TSC2(14) 11458530 121 80 117 51 64 17 7 15 16 2 0.277 1.000 1.000 362 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(13), BCAT2(1), IARS(10), IARS2(18), ILVBL(5), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1), VARS(16), VARS2(7) 8037888 114 79 105 54 76 12 3 11 12 0 0.340 1.000 1.000 363 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG3(2), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(32), ULK1(11), ULK2(7), ULK3(1) 8906155 135 79 129 72 94 8 6 15 12 0 0.423 1.000 1.000 364 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(3), CAT(8), EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49) 5044091 119 79 115 72 90 10 2 7 10 0 0.285 1.000 1.000 365 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(10), PIK3R1(4), PLCB1(61), PLCG1(9), PRKCA(9), VAV1(19) 5486267 116 79 107 59 87 5 2 9 11 2 0.332 1.000 1.000 366 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(8), ACTN2(21), CAPN1(5), CAPNS1(3), CAPNS2(1), ITGA1(23), ITGB1(7), ITGB3(25), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12) 11836369 130 79 128 68 80 12 7 14 16 1 0.0982 1.000 1.000 367 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 141 78 130 70 97 16 5 9 13 1 0.00254 1.000 1.000 368 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 141 78 130 70 97 16 5 9 13 1 0.00254 1.000 1.000 369 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL6(2), IL6R(3), IL6ST(11), JAK1(7), JAK2(8), JAK3(11), JUN(1), MAP2K1(18), MAPK3(3), PTPN11(10), RAF1(12), SHC1(2), SOS1(10), SRF(3), STAT3(11) 10150886 127 78 116 64 60 16 5 32 14 0 0.799 1.000 1.000 370 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16) 7028228 141 78 138 70 103 13 1 13 10 1 0.230 1.000 1.000 371 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SP1(5), SP3(1), SYT1(23) 8931852 129 77 121 56 83 13 7 11 14 1 0.190 1.000 1.000 372 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(4), BAD(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(6), MAP2K1(18), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RAF1(12), RALA(1), RALBP1(3), RALGDS(11), RELA(4), RHOA(3) 7884068 100 77 89 53 56 15 3 19 6 1 0.654 1.000 1.000 373 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(5), CS(2), DLD(3), DLST(1), FH(3), IDH1(15), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), PC(14), PCK1(28), SDHA(4), SUCLG1(4), SUCLG2(3) 8838194 106 76 91 57 73 2 6 12 13 0 0.405 1.000 1.000 374 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(6), ALOX15(11), ALOX15B(9), ALOX5(14), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(13), PTGDS(4), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 6367246 144 76 140 82 95 13 4 15 17 0 0.0806 1.000 1.000 375 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTAP(5), MTFMT(2), MTR(12), SRM(1), TAT(21) 8928478 123 76 121 54 76 11 8 12 15 1 0.0657 1.000 1.000 376 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(17), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(3), CAPNS2(1), EP300(19), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(18), NFATC2(12), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SYT1(23) 10461393 131 76 124 59 84 8 9 14 16 0 0.239 1.000 1.000 377 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(4), IL1A(5), IL1R1(12), IRAK1(5), MAP3K1(4), MAP3K7(1), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(42), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 10247356 109 76 102 67 75 7 4 12 11 0 0.814 1.000 1.000 378 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(13), CNR2(6), DNMT1(19), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), TBXA2R(5) 4758781 114 76 109 86 78 16 4 8 8 0 0.358 1.000 1.000 379 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(5), CARS(9), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(8), IARS(10), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3) 13730362 132 75 126 62 78 13 6 17 16 2 0.302 1.000 1.000 380 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(4), MAP2K1(18), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RB1(10), RELA(4), SP1(5) 8247701 94 75 83 48 46 12 4 13 16 3 0.763 1.000 1.000 381 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), NAT1(2), NAT2(10), XDH(61) 3426350 116 75 107 79 91 5 6 3 11 0 0.182 1.000 1.000 382 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(24), CPT1A(14), LEP(4), LEPR(31), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8) 6219439 121 75 113 58 83 5 3 11 19 0 0.483 1.000 1.000 383 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(9), TALDO1(4), TKT(6) 8709126 105 75 101 73 67 8 6 10 14 0 0.673 1.000 1.000 384 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(37), CD44(5), CSF1(12), FCGR3A(9), IL1B(8), IL6R(3), SELL(12), SPN(5), TGFB1(2), TGFB2(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3) 5536832 128 75 121 63 94 7 6 5 16 0 0.0715 1.000 1.000 385 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(6), MAP2K1(18), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10) 6825036 106 75 95 44 52 17 4 21 12 0 0.200 1.000 1.000 386 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(18), APOA1(1), APOA4(9), APOC1(3), APOC2(1), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(4), LDLR(19), LIPC(10), LPL(6), LRP1(47), SCARB1(5), SOAT1(3) 11782522 144 75 141 85 83 20 9 16 14 2 0.418 1.000 1.000 387 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(59), NRG2(9), NRG3(24), PRKCA(9), PSEN1(3) 3808560 105 74 94 39 76 5 3 6 15 0 0.0327 1.000 1.000 388 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPX1(3), PRKCE(7) 3305458 121 74 105 62 87 8 3 13 8 2 0.255 1.000 1.000 389 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(5), GLB1(10), HEXA(5), HEXB(4), LCT(54), SLC33A1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12) 7030462 134 74 132 82 90 12 1 19 12 0 0.600 1.000 1.000 390 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(8), EPX(9), LPO(20), MPO(12), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49) 4979106 113 74 109 72 88 9 1 7 8 0 0.398 1.000 1.000 391 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(20), AP2A1(2), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(10), EPN1(6), EPS15(4), NME1(1), PICALM(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(22), SYT1(23) 9128501 134 74 128 63 91 9 5 16 13 0 0.260 1.000 1.000 392 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(9), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(1), HAL(14) 8046098 120 74 116 66 83 7 4 16 10 0 0.597 1.000 1.000 393 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(12), SNCA(2), SNCAIP(67), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L3(1), UBE2L6(2) 2748962 104 74 93 36 79 10 3 5 7 0 0.0131 1.000 1.000 394 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TPO(49), TYR(11) 4120139 111 74 107 68 82 11 1 5 12 0 0.434 1.000 1.000 395 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4542831 126 74 116 54 85 8 4 7 20 2 0.00854 1.000 1.000 396 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4762451 133 74 122 59 89 8 4 8 22 2 0.0105 1.000 1.000 397 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(8), ACTN2(21), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(30), CTNNB1(17), PTK2(7), PXN(2), SRC(2), VCL(9) 8056585 105 73 100 61 63 8 8 12 13 1 0.408 1.000 1.000 398 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(34), FHL5(13), FSHB(9), FSHR(21), GNAS(33), XPO1(3) 4054852 113 73 104 51 77 12 6 8 10 0 0.192 1.000 1.000 399 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(4), CCND1(2), CCNE1(4), CDK2(1), CDK4(8), CDK6(2), CDKN1A(3), CDKN1B(2), E2F1(6), HRAS(6), MAPK1(4), MAPK3(3), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(4), RAF1(12), RB1(10), RELA(4), TFDP1(2) 8412966 99 73 93 50 42 12 8 19 15 3 0.678 1.000 1.000 400 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(4), BAD(4), GRB2(2), HRAS(6), IGF1R(15), IRS1(5), MAP2K1(18), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), RAF1(12), SHC1(2), SOS1(10) 8115541 99 72 86 45 55 13 4 17 9 1 0.436 1.000 1.000 401 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(27), ITGAM(25), ITGB2(17), SELE(33), SELL(12) 4384333 121 72 120 60 87 6 3 6 17 2 0.0738 1.000 1.000 402 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(6), GTF2A1(2), GTF2B(5), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(19), NCOR2(28), POLR2A(14), RARA(5), RXRA(4), TBP(4) 10591405 122 72 119 55 94 4 5 10 9 0 0.194 1.000 1.000 403 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(6), HSPA1A(1), IFNG(4), IFNGR1(4), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(35), WT1(10) 7165911 107 72 100 42 54 10 4 13 24 2 0.113 1.000 1.000 404 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(15), ATM(16), BRCA1(16), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(3), MDM2(4), MRE11A(5), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(5), RELA(4), TP73(6) 12304033 96 71 95 48 47 12 3 19 15 0 0.904 1.000 1.000 405 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PGK1(3), PKLR(14), TKT(6), TPI1(1) 7718937 105 71 102 60 74 11 4 6 9 1 0.206 1.000 1.000 406 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(4), CAT(8), GH1(5), GHR(43), HRAS(6), IGF1(11), IGF1R(15), PIK3CA(10), PIK3R1(4), SHC1(2) 5668311 108 71 99 45 73 12 2 13 7 1 0.129 1.000 1.000 407 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(10), CD2(29), CD3D(7), CD3E(2), CD3G(1), CD4(9), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(9) 6208723 134 71 124 61 90 10 4 10 20 0 0.0639 1.000 1.000 408 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(4), BAX(5), BCL2(3), CASP8(9), CYCS(1), MAP2K1(18), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFKB1(6), NSMAF(6), RAF1(12), RELA(4), RIPK1(3), SMPD1(3), TNFRSF1A(4), TRAF2(2) 8701488 98 70 88 48 56 9 5 15 13 0 0.529 1.000 1.000 409 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K1(18), MAPK3(3), MAPK8(3), PLCG1(9), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 9098879 100 70 90 50 51 8 7 19 15 0 0.600 1.000 1.000 410 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(4), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MPST(2), SDS(3), SULT1B1(11), SULT1C2(7), SULT1C4(15), SULT4A1(11) 5361463 108 70 104 34 71 5 11 8 13 0 0.00140 1.000 1.000 411 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(7), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), METTL2B(5), METTL6(2), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SCLY(3), SEPHS1(2), SEPHS2(2), WBSCR22(2) 10680917 110 70 108 61 65 13 5 15 12 0 0.427 1.000 1.000 412 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), KLK2(5), MAP2K1(18), MAPK3(3), MAPK8(3), NGFR(8), PIK3CA(10), PIK3R1(4), PLCG1(9), RAF1(12), SHC1(2), SOS1(10) 8122631 101 70 90 47 52 12 3 22 11 1 0.591 1.000 1.000 413 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), BAD(4), CHRNB1(4), CHRNG(3), MUSK(38), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), RAPSN(1), SRC(2), TERT(10) 6942853 99 69 95 84 64 8 1 17 8 1 0.991 1.000 1.000 414 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(16), AOC2(9), AOC3(9), CES1(21), DDHD1(8), ESCO1(2), ESCO2(4), LIPA(5), NAT6(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2) 10815802 99 69 95 58 74 4 7 6 8 0 0.821 1.000 1.000 415 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(24), DAXX(10), HRAS(6), PAX3(3), PML(16), RARA(5), RB1(10), SIRT1(2), SP100(12), TNF(1), TNFRSF1A(4), TNFRSF1B(4) 7686287 97 69 97 42 42 15 7 14 17 2 0.332 1.000 1.000 416 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(7), CREBBP(24), EP300(19), NCOA3(19), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(5), RXRA(4) 8838285 105 68 105 57 63 8 5 17 12 0 0.846 1.000 1.000 417 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK2(1), CDK4(8), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), E2F1(6), RB1(10), RBL1(14), TFDP1(2) 6625827 92 67 88 32 47 5 8 18 12 2 0.0560 1.000 1.000 418 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(4), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), CASP3(3), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(9), PTK2(7), PXN(2), STAT1(5), TLN1(12) 11283078 85 67 82 52 48 10 5 12 10 0 0.891 1.000 1.000 419 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(39), AKT1(4), ATM(16), BAX(5), CDKN1A(3), CPB2(1), CSNK1A1(5), CSNK1D(3), HIC1(2), HIF1A(4), HSPA1A(1), IGFBP3(3), MAPK8(3), MDM2(4), NFKBIB(1), NQO1(2) 8512093 96 67 86 48 57 7 3 14 14 1 0.714 1.000 1.000 420 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSR(2), GSS(9), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(61) 4206671 99 66 94 52 72 8 4 7 8 0 0.140 1.000 1.000 421 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(7), LPO(20), MPO(12), PRDX6(4), TPO(49) 3577255 101 66 97 66 78 9 1 5 8 0 0.474 1.000 1.000 422 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(4), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(11), IGF1R(15), INPPL1(16), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4) 8036600 85 66 79 46 50 12 6 9 7 1 0.670 1.000 1.000 423 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(38), MAP2(22), PPP1CA(3), PPP2CA(1), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(7) 7722806 94 65 93 51 51 10 7 11 14 1 0.874 1.000 1.000 424 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(27), AXIN1(10), BTRC(4), CTNNB1(17), DLL1(3), DVL1(1), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(3), WNT1(2) 9023786 85 65 84 52 41 10 7 11 16 0 0.942 1.000 1.000 425 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(4), AP2A1(2), AP2M1(3), BAD(4), BTK(15), EEA1(3), GRASP(3), GSK3A(1), GSK3B(3), LYN(11), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PLCG1(9), PRKCE(7), PRKCZ(3), RAB5A(2), RPS6KB1(4), VAV2(5) 10372921 91 65 89 67 52 10 6 7 16 0 0.867 1.000 1.000 426 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), BAD(4), CASP9(2), CHUK(2), GH1(5), GHR(43), NFKB1(6), NFKBIA(2), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4) 5968669 92 64 85 50 61 9 5 10 6 1 0.729 1.000 1.000 427 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(10), SYT1(23) 4947143 96 64 90 70 65 8 3 9 11 0 0.853 1.000 1.000 428 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CTLA4(2), GRB2(2), HLA-DRA(13), HLA-DRB1(5), ICOS(3), IL2(4), ITK(25), LCK(17), PIK3CA(10), PIK3R1(4), PTPN11(10) 5166398 111 64 107 44 73 8 2 15 11 2 0.185 1.000 1.000 429 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), TYR(11) 6398037 101 64 97 32 65 7 5 7 17 0 0.0170 1.000 1.000 430 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1) 10017523 93 64 90 47 53 10 6 18 6 0 0.543 1.000 1.000 431 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(19), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(8) 8528020 99 64 96 63 63 11 3 11 11 0 0.692 1.000 1.000 432 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(29), CD38(6), ENPP1(13), ENPP3(15), NADSYN1(4), NMNAT1(1), NMNAT2(7), NNMT(11), NNT(4), NT5E(7), NT5M(2), QPRT(6) 6212326 105 64 98 47 65 9 5 12 14 0 0.214 1.000 1.000 433 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(5), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP4K2(7), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2) 10155954 77 64 77 46 45 10 3 8 10 1 0.710 1.000 1.000 434 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(7), CD3E(2), CD3G(1), CD4(9), FYN(8), HLA-DRA(13), HLA-DRB1(5), LCK(17), PTPRC(36), ZAP70(8) 3783076 106 64 100 41 71 8 3 9 14 1 0.0194 1.000 1.000 435 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(8), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), GAMT(5), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(5) 7380470 92 64 89 40 54 9 5 13 11 0 0.137 1.000 1.000 436 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(54), MPI(2), PGM1(8), PYGL(9), PYGM(14), TPI1(1), TREH(4) 5632350 97 63 96 73 70 7 2 11 7 0 0.753 1.000 1.000 437 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(3), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(2), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1) 9608800 81 63 81 54 43 7 7 14 10 0 0.860 1.000 1.000 438 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTR(12) 7512788 94 63 93 38 56 9 7 10 11 1 0.0419 1.000 1.000 439 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), FDXR(12), SHMT1(2) 6838473 94 63 93 51 55 4 7 13 15 0 0.341 1.000 1.000 440 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(4), PRF1(14), SCAP(12), SREBF1(5), SREBF2(10) 7765698 97 63 93 48 57 9 7 14 10 0 0.377 1.000 1.000 441 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(5), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2) 8161439 84 62 78 41 45 6 2 12 19 0 0.560 1.000 1.000 442 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(3), CCR5(10), CXCL12(8), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(3), PLCG1(9), PRKCA(9), PTK2B(12), SYT1(23) 5899387 96 62 89 75 64 7 5 13 7 0 0.946 1.000 1.000 443 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), IDS(9), IDUA(8), LCT(54), NAGLU(4) 6107486 109 62 107 62 81 9 0 10 9 0 0.466 1.000 1.000 444 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(24), ACACB(23), FASN(26), MCAT(2), OLAH(11), OXSM(2) 6754738 88 62 86 53 53 9 3 8 15 0 0.506 1.000 1.000 445 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(8), B3GAT2(3), B3GAT3(4), CHPF(4), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(9), DSE(20), XYLT1(12), XYLT2(5) 5811712 90 62 90 62 57 13 4 8 8 0 0.545 1.000 1.000 446 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(9), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(13), HLA-DRB1(5), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(4), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), LTA(5), PDGFA(1), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1) 5614094 114 62 111 58 75 5 3 11 20 0 0.0211 1.000 1.000 447 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(24), EP300(19), LPL(6), NCOA1(9), NCOA2(13), PPARG(12), RXRA(4) 7931311 87 62 84 36 52 11 4 12 8 0 0.395 1.000 1.000 448 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 449 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 450 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(5), GPR34(3), GPR39(12), GPR45(8), GPR65(14), GPR68(3), GPR75(6) 4172726 78 61 75 41 54 5 3 8 8 0 0.0139 1.000 1.000 451 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(6), COPS5(3), EDN1(9), EP300(19), EPO(5), HIF1A(4), JUN(1), LDHA(6), NOS3(20), P4HB(3), VHL(4) 7297451 89 61 86 41 57 5 5 10 12 0 0.562 1.000 1.000 452 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 5173131 81 61 75 31 47 10 4 11 9 0 0.0233 1.000 1.000 453 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(7), ATM(16), BAX(5), BCL2(3), CCND1(2), CCNE1(4), CDK2(1), CDK4(8), CDKN1A(3), E2F1(6), MDM2(4), PCNA(2), RB1(10), TIMP3(5) 7337140 76 61 71 31 29 8 4 18 15 2 0.550 1.000 1.000 454 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 455 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(15), GPLD1(27), KDELR1(1), KDELR3(3) 6983853 81 60 79 46 41 7 3 17 13 0 0.690 1.000 1.000 456 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), GRB2(2), HRAS(6), MAPK1(4), MAPK3(3), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), RPS6KA1(11), SHC1(2) 8066485 92 60 89 63 55 14 5 9 8 1 0.923 1.000 1.000 457 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13) 4320806 97 60 97 46 66 7 2 6 15 1 0.0649 1.000 1.000 458 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(6), BIRC3(7), CASP3(3), CASP8(9), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 11547447 84 60 83 57 47 4 9 13 11 0 0.964 1.000 1.000 459 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(35), HSD17B2(13), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(15), HSD3B2(14) 3418004 96 60 90 38 68 6 6 4 12 0 0.0211 1.000 1.000 460 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(4), LMNA(5), LMNB1(2), LMNB2(4), PRF1(14) 8328136 93 59 92 48 51 11 7 14 10 0 0.641 1.000 1.000 461 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(6), KLK2(5), MAP2K1(18), MAP2K2(5), MAPK1(4), MAPK3(3), NGFR(8), RAF1(12) 3471788 73 59 62 32 38 8 3 13 11 0 0.0907 1.000 1.000 462 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADM(5), ACADS(6), ACADVL(1), ACSL1(9), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(2), EHHADH(6), HADHA(6), PECR(2), SCP2(4), SLC25A20(1) 7229827 74 59 70 36 47 4 3 8 12 0 0.563 1.000 1.000 463 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CDK2(1), CDK4(8), CHEK1(2), MYT1(21), RB1(10), WEE1(2) 7143279 77 59 71 31 40 5 3 16 11 2 0.405 1.000 1.000 464 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(12), RBL2(6), SHC1(2), SOS1(10) 8413700 76 59 75 49 39 9 3 19 6 0 0.961 1.000 1.000 465 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(15), E2F1(6), MDM2(4), MYC(5), PIK3CA(10), PIK3R1(4), POLR1A(13), POLR1B(9), POLR1C(1), RB1(10), TBX2(6), TWIST1(1) 7857531 84 58 82 34 48 9 3 11 10 3 0.185 1.000 1.000 466 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26) 7138206 70 58 69 38 39 9 2 13 7 0 0.556 1.000 1.000 467 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6(2), IL6R(3), JAK1(7), JAK2(8), JAK3(11), PIAS3(6), PTPRU(23), REG1A(8), SRC(2), STAT3(11) 6479384 85 58 84 55 48 10 3 10 14 0 0.772 1.000 1.000 468 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(12), CYP11A1(14), CYP11B2(12), CYP17A1(7), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 2941950 90 57 85 58 66 9 1 5 9 0 0.0645 1.000 1.000 469 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(40), CYP2C9(41) 862439 81 57 73 58 61 5 2 2 11 0 0.830 1.000 1.000 470 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(26), HADHA(6), HSD17B12(4), PECR(2), SCD(4) 6109332 78 57 78 37 48 7 4 8 11 0 0.0492 1.000 1.000 471 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(2), HLA-DRA(13), HLA-DRB1(5), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(7), IL4(1), IL4R(18) 5100323 111 57 106 45 84 5 0 7 15 0 0.0308 1.000 1.000 472 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(18), NFATC2(12), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5161279 88 56 84 56 57 9 3 5 14 0 0.607 1.000 1.000 473 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(7), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 6426475 77 56 75 41 46 10 1 13 7 0 0.428 1.000 1.000 474 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(2), IL22RA1(13), IL22RA2(3), JAK1(7), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), TYK2(9) 7778061 87 56 87 57 50 7 6 15 9 0 0.848 1.000 1.000 475 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(22), EGFR(26), ERBB3(7), NRG1(23), UBE2D1(1) 4414469 79 55 79 51 54 4 3 8 9 1 0.955 1.000 1.000 476 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(7), JAK2(8), JAK3(11), PIAS1(7), PIAS3(6), PTPRU(23), REG1A(8), SOAT1(3) 5825301 77 55 76 35 47 9 2 6 13 0 0.167 1.000 1.000 477 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(22), EGFR(26), HGS(5), RAB5A(2), TF(16), TFRC(4) 5473784 78 54 78 50 52 5 5 6 10 0 0.904 1.000 1.000 478 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), GCNT2(7), ST3GAL6(4), ST8SIA1(1) 6530877 74 54 72 46 40 12 5 7 9 1 0.600 1.000 1.000 479 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(4), BCAR1(5), CDKN1B(2), GRB2(2), ILK(2), ITGB1(7), MAPK1(4), MAPK3(3), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PTK2(7), SHC1(2), SOS1(10) 7844630 71 54 69 41 36 10 5 15 4 1 0.927 1.000 1.000 480 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(24), EP300(19), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 9521393 82 54 82 39 45 10 6 13 8 0 0.483 1.000 1.000 481 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(33), GNB1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9) 4059172 74 53 70 41 52 8 3 6 5 0 0.726 1.000 1.000 482 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(2), GCK(16), GFPT1(6), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), PGM3(1), RENBP(3), UAP1(2) 7242946 79 53 76 55 51 5 2 12 9 0 0.915 1.000 1.000 483 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(5), CD3D(7), CD3E(2), CD3G(1), GZMB(4), HLA-A(4), ICAM1(2), ITGAL(27), ITGB2(17), PRF1(14) 3717659 83 53 82 38 48 8 3 5 18 1 0.0550 1.000 1.000 484 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(12), ACYP1(1), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(7), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 11127647 77 53 76 47 42 11 6 12 6 0 0.906 1.000 1.000 485 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(7), BCL2(3), CASP3(3), CASP9(2), CYCS(1), DAXX(10), FAS(5), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1) 4856088 69 53 67 37 43 7 3 7 9 0 0.461 1.000 1.000 486 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(1), GRB2(2), HRAS(6), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), SHC1(2), SOS1(10) 6637650 78 53 76 43 44 10 3 11 9 1 0.802 1.000 1.000 487 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), PSMA7(1), WASF1(5), WASF2(6), WASF3(14), WASL(4) 6348133 72 52 71 38 44 7 4 9 8 0 0.818 1.000 1.000 488 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), CHST1(11), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 5319249 73 52 72 49 47 15 3 4 4 0 0.551 1.000 1.000 489 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(3), CCR3(11), CD4(9), HLA-DRA(13), HLA-DRB1(5), IL1B(8), IL4(1), IL5(4), IL5RA(17), IL6(2) 2279822 73 52 67 38 55 0 1 6 11 0 0.0595 1.000 1.000 490 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), WASL(4) 5555636 70 51 69 26 45 4 3 11 6 1 0.219 1.000 1.000 491 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(16), AMT(1), ATIC(5), DHFR(1), FTCD(4), GART(10), MTFMT(2), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 8079674 77 51 75 44 52 6 3 8 8 0 0.615 1.000 1.000 492 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1D(3), CSNK1E(5), NPAS2(6), NR1D1(1), PER1(8), PER2(12), PER3(12) 7252975 73 51 69 51 49 7 1 6 10 0 0.946 1.000 1.000 493 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(9), CHAT(20), CHKA(2), PCYT1A(3), PDHA1(5), PDHA2(20), PEMT(3), SLC18A3(2) 2931222 64 50 60 33 45 7 2 3 6 1 0.164 1.000 1.000 494 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(4), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(2), SIRT1(2), SIRT2(1), SIRT5(6), SIRT7(3), VNN2(17) 5055319 61 50 59 19 38 8 4 7 4 0 0.0392 1.000 1.000 495 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(10), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(12), JUND(1), MYOG(3), NR4A3(10), WDR1(6) 4534195 64 50 59 31 42 5 2 5 10 0 0.462 1.000 1.000 496 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(12), HDAC9(45), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1) 3182933 80 50 70 39 64 6 2 3 5 0 0.209 1.000 1.000 497 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(24), EP300(19), ESR1(6), MAPK1(4), MAPK3(3), PELP1(14), SRC(2) 6263992 72 50 71 37 44 7 5 11 5 0 0.639 1.000 1.000 498 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(5), MAPK8(3), NFKB1(6), RELA(4), TNFRSF13B(11), TNFRSF17(7), TNFSF13B(3), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 6134800 60 50 59 26 42 6 0 8 4 0 0.239 1.000 1.000 499 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(13), ARHGDIB(4), CASP1(4), CASP10(10), CASP3(3), CASP8(9), CASP9(2), CYCS(1), GZMB(4), JUN(1), PRF1(14) 5517335 72 49 70 35 46 5 3 13 5 0 0.608 1.000 1.000 500 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(5), AFMID(2), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5716791 66 49 62 39 36 5 4 7 14 0 0.633 1.000 1.000 501 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(18), IRS1(5), JAK1(7), JAK3(11), RPS6KB1(4), SHC1(2), STAT6(9) 6294755 66 49 65 32 37 10 4 8 7 0 0.278 1.000 1.000 502 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(16), AMT(1), ATIC(5), ATP6V0C(3), DHFR(1), GART(10), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 7629387 74 49 72 37 49 6 4 8 7 0 0.337 1.000 1.000 503 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(5), ENO3(4), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3) 3561109 67 49 64 34 44 6 2 7 8 0 0.132 1.000 1.000 504 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(10), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(15), PON2(3), PON3(6), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 3856527 72 48 71 35 52 4 2 7 7 0 0.116 1.000 1.000 505 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(5), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5) 9515594 57 48 57 49 36 6 1 6 8 0 0.994 1.000 1.000 506 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(3), OPRK1(23), POLR2A(14), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5485395 70 47 69 67 51 3 4 5 7 0 0.997 1.000 1.000 507 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5458276 64 47 60 35 35 5 3 7 14 0 0.514 1.000 1.000 508 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(29), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), KITLG(10) 2619952 74 47 66 33 53 3 2 8 8 0 0.0671 1.000 1.000 509 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(7), BAK1(2), BAX(5), BCL2(3), BIK(2), BIRC2(6), BIRC3(7), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(3) 5753598 58 47 57 21 29 6 7 6 10 0 0.228 1.000 1.000 510 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(6), JAK1(7), PTPRU(23), REG1A(8), STAT1(5), STAT2(6), TYK2(9) 5351023 67 47 66 37 38 8 1 8 12 0 0.347 1.000 1.000 511 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2) 5870983 58 46 56 27 38 4 2 8 6 0 0.563 1.000 1.000 512 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(14), CDO1(6), CSAD(7), GAD1(14), GAD2(9), GGT1(8) 2421221 58 46 55 36 36 8 4 5 5 0 0.626 1.000 1.000 513 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(7), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 5990805 66 46 64 34 38 8 3 11 6 0 0.467 1.000 1.000 514 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(11), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4) 5348314 53 45 52 27 24 6 6 5 12 0 0.652 1.000 1.000 515 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(7), CHST12(7), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(3), SULT1E1(16), SULT2A1(9), SULT2B1(6), SUOX(4) 3896847 78 45 75 43 57 6 0 6 9 0 0.321 1.000 1.000 516 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(2), BNIP1(4), GOSR1(2), GOSR2(3), SNAP25(9), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(2), STX3(2), STX4(1), STX5(4), STX6(2), TSNARE1(5), USE1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP7(8), VAMP8(1), VTI1A(1), VTI1B(1) 7070200 63 45 61 32 38 4 2 9 10 0 0.305 1.000 1.000 517 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(1), IL10(2), IL10RA(9), IL10RB(7), IL1A(5), IL6(2), JAK1(7), STAT1(5), STAT3(11), STAT5A(3), TNF(1) 5208279 56 45 55 36 30 4 5 8 9 0 0.663 1.000 1.000 518 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(3), ME1(22), PC(14), PDHA1(5), SLC25A11(4) 3974326 62 45 60 30 39 6 2 10 4 1 0.180 1.000 1.000 519 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(6), IFNAR1(3), IFNAR2(11), IFNB1(6), MAPK8(3), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4) 4723058 55 45 54 29 37 3 1 8 6 0 0.655 1.000 1.000 520 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(4), HMGB2(2), NME1(1), PRF1(14), SET(3) 4524146 68 45 66 27 37 6 6 11 8 0 0.224 1.000 1.000 521 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL15(4), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL9(1), LTA(5), TNF(1) 4210761 67 44 65 42 45 3 2 4 13 0 0.369 1.000 1.000 522 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(25), CKM(3), GPT(4), LDHA(6), LDHB(2), LDHC(7), MAPK14(5), NCL(6) 3838812 58 44 55 29 39 7 6 3 3 0 0.332 1.000 1.000 523 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(4), IFNGR1(4), JAK1(7), JAK2(8), PLA2G2A(2), PTPRU(23), REG1A(8), STAT1(5) 4868210 65 44 64 28 37 6 1 6 15 0 0.173 1.000 1.000 524 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), IMPA2(5), ISYNA1(1), PGM1(8), PGM3(1), TGDS(1) 4973149 66 43 64 45 46 5 2 7 6 0 0.664 1.000 1.000 525 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(19), MBTPS1(9), MBTPS2(3), SCAP(12), SREBF1(5), SREBF2(10) 5067953 60 43 57 30 40 3 3 10 4 0 0.299 1.000 1.000 526 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(9), CYP2E1(14), NR1I3(7), PTGS1(20), PTGS2(13) 2299063 63 42 61 37 47 5 0 2 9 0 0.255 1.000 1.000 527 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(4), BAK1(2), BAX(5), BCL10(3), BCL2(3), BCL2L11(8), CASP9(2), CES1(21) 4579626 55 42 52 23 39 6 3 3 4 0 0.331 1.000 1.000 528 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(4), FUT2(4), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST8SIA1(1) 4292931 52 41 50 39 29 7 3 8 5 0 0.867 1.000 1.000 529 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(12), ACO1(8), ACO2(5), ACSS1(2), ACSS2(5), FH(3), IDH1(15), IDH2(2), MDH1(3), MDH2(4) 5708843 59 41 47 35 38 0 2 9 10 0 0.653 1.000 1.000 530 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(12), CAPN1(5), CAPNS1(3), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(5), CSNK1D(3), GSK3B(3), MAPT(10), PPP2CA(1) 3844516 50 41 48 24 30 4 2 7 7 0 0.335 1.000 1.000 531 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), PAPSS1(4), PAPSS2(5), SCLY(3), SEPHS1(2) 5313609 55 41 55 31 33 5 4 6 7 0 0.428 1.000 1.000 532 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9) 4464580 54 41 54 27 37 2 2 7 6 0 0.489 1.000 1.000 533 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9) 4464580 54 41 54 27 37 2 2 7 6 0 0.489 1.000 1.000 534 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(6), FOS(2), FYN(8), JUN(1), MAPK14(5), THBS1(31) 3160320 56 41 55 34 36 2 4 5 9 0 0.814 1.000 1.000 535 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 536 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 537 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(2), DHCR7(10), FDFT1(1), FDPS(3), GGCX(2), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SQLE(4), TM7SF2(5) 8219769 53 40 53 41 28 11 2 9 3 0 0.960 1.000 1.000 538 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4) 5721949 54 40 52 25 30 6 2 12 4 0 0.381 1.000 1.000 539 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), PGM1(8), PGM3(1), TGDS(1) 4367056 60 40 58 40 42 5 2 6 5 0 0.659 1.000 1.000 540 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(7), IL4(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), TOB1(3), TOB2(3) 4494803 61 40 61 31 46 3 1 1 10 0 0.259 1.000 1.000 541 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4) 7697587 41 39 41 33 25 6 1 4 5 0 0.979 1.000 1.000 542 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(4), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1) 6878598 48 39 47 24 26 6 2 10 4 0 0.630 1.000 1.000 543 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(9), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL9(1) 2580061 57 39 55 37 38 2 1 6 10 0 0.374 1.000 1.000 544 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(27), GNA12(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5) 4312019 53 38 53 33 33 4 1 9 6 0 0.846 1.000 1.000 545 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(16), GOT1(6), GOT2(6), TAT(21), TYR(11) 2008554 60 38 58 31 44 5 3 2 6 0 0.302 1.000 1.000 546 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(16), CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2) 3635220 49 38 49 20 28 2 4 7 6 2 0.248 1.000 1.000 547 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(9), CPS1(29), GLS(2), GLUD1(2), GOT1(6) 3274065 50 38 47 21 33 4 2 9 2 0 0.292 1.000 1.000 548 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), DHFR(1), FPGS(3), GGH(4), SPR(4) 2730835 53 37 49 27 37 5 4 1 6 0 0.0732 1.000 1.000 549 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(7), FUT1(4), FUT2(4), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 4025180 46 37 44 30 25 7 1 7 6 0 0.672 1.000 1.000 550 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(22), CDC25C(5), CHEK1(2), CHEK2(2) 6462961 47 37 46 26 33 3 2 5 4 0 0.890 1.000 1.000 551 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(7), JAK2(8), JAK3(11), MAPK1(4), MAPK3(3), STAT3(11), TYK2(9) 4971829 53 37 53 42 28 6 4 8 7 0 0.966 1.000 1.000 552 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNAR2(11), IFNB1(6), JAK1(7), STAT1(5), STAT2(6), TYK2(9) 4609311 48 36 48 24 30 3 2 8 5 0 0.410 1.000 1.000 553 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(9), AOC3(9), CES1(21), ESD(3) 2570858 42 35 39 25 32 2 1 3 4 0 0.548 1.000 1.000 554 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), LTB4R(1), P2RY1(5), P2RY2(10), P2RY6(2) 2546495 42 35 41 34 27 6 2 4 2 1 0.291 1.000 1.000 555 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(13), EIF2AK4(16), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF5(2), GSK3B(3), PPP1CA(3) 4952542 43 34 42 20 23 4 1 9 6 0 0.633 1.000 1.000 556 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(5), FH(3), IDH1(15), IDH2(2), MDH1(3), MDH2(4) 3829553 40 34 28 20 26 0 2 5 7 0 0.460 1.000 1.000 557 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(7), TAX1BP3(1), UBE2A(1), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(3), UBE2J1(2), UBE2J2(8), UBE2L3(1), UBE2L6(2), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(6) 4513798 47 34 45 23 33 4 2 4 4 0 0.550 1.000 1.000 558 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), FBXW7(11), RB1(10), TFDP1(2) 3483175 41 33 40 17 18 2 5 5 9 2 0.395 1.000 1.000 559 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(3), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(5), PPT2(1) 3623871 38 33 38 16 23 4 4 3 4 0 0.312 1.000 1.000 560 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(15), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(4), FUT2(4), FUT3(8), ST3GAL3(3), ST3GAL4(1) 3064649 39 33 37 25 25 6 2 2 4 0 0.574 1.000 1.000 561 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(4), RPN2(4), UBE2A(1), UBE3A(6) 5529517 41 33 41 22 24 5 2 7 3 0 0.664 1.000 1.000 562 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(2), ALAS2(6), CPO(5), FECH(3), GATA1(4), HBA1(1), HBB(8), HMBS(1), UROS(1) 3298723 36 32 35 20 27 2 0 2 5 0 0.382 1.000 1.000 563 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(3), PGK1(3), PKLR(14), TPI1(1) 3925043 45 32 42 28 29 4 1 5 6 0 0.322 1.000 1.000 564 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(6), GREB1(23), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(5) 4570886 50 32 49 28 35 4 4 3 4 0 0.312 1.000 1.000 565 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 BFAR(2), CAMP(2), CREB3(1), CREB5(9), MAPK1(4), RAF1(12), SNX13(5), SRC(2), TERF2IP(2) 4123067 39 32 37 29 28 3 1 4 3 0 0.935 1.000 1.000 566 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1E(5), PER1(8) 3605154 39 31 38 23 26 5 1 3 4 0 0.801 1.000 1.000 567 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 7104319 40 31 40 27 24 3 4 6 3 0 0.950 1.000 1.000 568 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), ADSS(2), DHFR(1), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(8), PRPS2(3), RRM1(3), SRM(1) 5315371 38 31 38 36 22 2 2 5 7 0 0.995 1.000 1.000 569 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(9), CD80(4), HLA-DRA(13), HLA-DRB1(5), IL10(2), IL2(4), IL4(1) 1685448 40 30 38 22 28 0 0 6 5 1 0.230 1.000 1.000 570 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), HMGCS1(2), IDI1(1), LSS(4), MVD(1), MVK(2), NSDHL(3), PMVK(2), SQLE(4) 5613075 38 30 38 28 19 8 1 8 2 0 0.958 1.000 1.000 571 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(4), DFFA(2), DFFB(2), GZMB(4), HMGB1(1), HMGB2(2), TOP2A(11), TOP2B(9) 3787166 38 30 37 12 25 2 5 2 4 0 0.216 1.000 1.000 572 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(9), PTPRA(9), SRC(2) 3961867 40 30 39 27 28 4 1 3 4 0 0.785 1.000 1.000 573 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(6), PTK2B(12), SHC1(2), SOS1(10), SRC(2) 3758030 34 29 34 31 22 3 0 6 3 0 0.997 1.000 1.000 574 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(10), PLCG1(9), PRKCA(9), PTK2B(12) 2884962 40 29 38 35 31 3 1 2 3 0 0.825 1.000 1.000 575 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 3358600 35 29 35 21 20 7 2 3 3 0 0.649 1.000 1.000 576 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(3), CSF1(12), IL1B(8), MST1(2), MST1R(10), TNF(1) 2797568 36 29 35 33 25 5 1 2 3 0 0.968 1.000 1.000 577 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDK2(1), CDKN1B(2), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2), UBE2M(1) 3665141 32 29 32 17 13 2 5 4 6 2 0.675 1.000 1.000 578 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 3515682 33 29 33 16 22 1 2 3 5 0 0.416 1.000 1.000 579 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), IDI1(1), LSS(4), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SQLE(4) 4698459 35 28 35 29 17 6 1 8 3 0 0.978 1.000 1.000 580 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), SDS(3) 3568463 32 27 31 20 21 4 1 2 4 0 0.797 1.000 1.000 581 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(4), OXCT2(5) 3051553 39 27 37 22 24 5 1 4 5 0 0.714 1.000 1.000 582 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(3), NFE2L2(4), PRKCA(9) 3783534 32 26 30 18 22 1 0 3 6 0 0.666 1.000 1.000 583 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(25), RANGAP1(3) 3635217 29 26 28 13 20 2 1 1 5 0 0.681 1.000 1.000 584 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(10), EPHX2(6), HSD3B7(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 2057178 30 25 30 19 19 2 3 3 3 0 0.555 1.000 1.000 585 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NFS1(4), TPK1(11) 2729917 27 25 27 14 17 1 2 2 5 0 0.766 1.000 1.000 586 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(29), PDXK(2), PNPO(1), PSAT1(4) 2078451 36 25 34 23 28 1 2 4 1 0 0.761 1.000 1.000 587 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB10(2), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4) 3756764 32 25 32 13 17 4 2 7 2 0 0.446 1.000 1.000 588 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(7), APOBEC1(3), APOBEC2(5), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(3) 3153147 28 24 27 38 20 2 3 2 1 0 1.000 1.000 1.000 589 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3) 3720288 29 24 29 13 17 3 3 4 2 0 0.532 1.000 1.000 590 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST3GAL5(3), ST6GALNAC2(3), ST6GALNAC4(4), ST8SIA1(1) 2421539 23 23 23 13 14 3 2 3 1 0 0.470 1.000 1.000 591 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(4), IFNGR2(4), JAK1(7), JAK2(8), STAT1(5) 3480656 32 23 30 13 15 1 1 5 10 0 0.626 1.000 1.000 592 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), IDH2(2), MDH1(3), OGDH(10), SDHA(4) 4043724 29 23 29 24 18 0 2 6 3 0 0.953 1.000 1.000 593 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(7), HADHA(6), SDS(3) 3331751 27 22 26 13 17 4 0 3 3 0 0.430 1.000 1.000 594 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(2), ALAS2(6), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1) 3228730 25 22 25 13 17 2 1 2 3 0 0.489 1.000 1.000 595 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(3), FURIN(7), NOTCH1(9), PSEN1(3) 3928050 23 22 23 21 12 4 2 4 1 0 0.941 1.000 1.000 596 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), WASF1(5), WASL(4) 3291311 29 22 29 12 17 4 2 4 2 0 0.420 1.000 1.000 597 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9) 1367799 31 22 30 23 22 2 0 3 4 0 0.631 1.000 1.000 598 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1) 2985660 22 21 22 13 13 1 1 6 1 0 0.865 1.000 1.000 599 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(8), BMPR1A(2), BMPR1B(4), BMPR2(7) 2683733 21 20 21 11 10 4 2 3 2 0 0.642 1.000 1.000 600 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(4), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 2066224 22 19 20 11 14 3 0 3 2 0 0.443 1.000 1.000 601 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(6), GBA(7), GGT1(8), SHMT1(2), SHMT2(3) 2292319 26 18 25 15 19 3 0 3 1 0 0.432 1.000 1.000 602 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(3), EIF2S1(1), NFKB1(6), NFKBIA(2), RELA(4) 3782875 18 18 18 9 10 3 1 2 2 0 0.595 1.000 1.000 603 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(3), FUT1(4), FUT2(4), GCNT2(7), ST8SIA1(1) 2274686 19 17 19 13 11 2 2 3 1 0 0.738 1.000 1.000 604 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(1), HGD(15) 956700 20 17 20 19 13 3 2 0 2 0 0.932 1.000 1.000 605 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(2), CBS(7), CTH(1), MUT(5) 2158481 16 16 16 10 11 2 1 1 1 0 0.703 1.000 1.000 606 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(3), KARS(4) 1992973 15 15 15 7 13 0 0 2 0 0 0.629 1.000 1.000 607 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(2), RAB5A(2) 1797950 17 15 16 12 13 2 0 1 1 0 0.792 1.000 1.000 608 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2) 2324817 18 14 18 17 5 5 3 3 2 0 0.987 1.000 1.000 609 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(3), GGT1(8), SHMT1(2), SHMT2(3) 1737524 16 13 16 13 11 2 1 2 0 0 0.765 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(20) 780976 21 13 20 15 15 2 1 2 1 0 0.772 1.000 1.000 611 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4) 1253962 22 13 21 10 14 2 0 1 5 0 0.317 1.000 1.000 612 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(6) 2099109 11 11 11 11 5 0 1 0 5 0 0.979 1.000 1.000 613 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(7) 1320714 11 11 11 11 7 0 1 2 1 0 0.936 1.000 1.000 614 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4) 1813037 11 11 11 7 6 1 1 3 0 0 0.769 1.000 1.000 615 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(6) 1645771 10 10 10 10 4 0 1 0 5 0 0.973 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 909034 5 5 5 5 5 0 0 0 0 0 0.858 1.000 1.000