rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(12) 306695 12 12 11 3 10 1 1 0 0 0 0.131 0.257 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(5) 219519 5 5 5 1 5 0 0 0 0 0 0.373 0.377 1.000 3 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(6), TAT(21) 1124647 33 21 32 9 24 3 2 1 3 0 0.0125 0.914 1.000 4 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(8), SNAP25(9), VAMP2(1) 1396359 23 21 21 4 16 1 0 3 3 0 0.00233 0.958 1.000 5 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 708066 5 5 4 1 3 0 0 2 0 0 0.339 0.976 1.000 6 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(2) 659766 4 3 4 0 0 2 0 1 1 0 0.334 0.983 1.000 7 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(7), CD3E(2), CD3G(1) 480032 10 7 10 4 8 0 0 0 2 0 0.405 0.993 1.000 8 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(1), ALDOB(14), ALDOC(4), TPI1(1) 1685752 24 19 21 7 17 2 0 2 3 0 0.0344 0.998 1.000 9 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(6), FOSB(6), GRIA2(43), JUND(1), PPP1R1B(2) 1573577 58 50 55 22 35 3 2 9 9 0 0.114 0.998 1.000 10 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 6 CHRM1(5), GNAQ(6), GNB1(1), PLCB1(61), TUB(10) 2651089 83 55 75 29 64 2 2 7 8 0 0.00646 0.999 1.000 11 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), SLPI(6) 734750 15 14 15 7 7 1 0 6 1 0 0.587 0.999 1.000 12 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), CASP3(3), CASP8(9), CFL1(2), CFLAR(5), PDE6D(2) 1669286 24 22 23 9 10 3 3 5 3 0 0.370 0.999 1.000 13 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RELA(4) 3497971 88 61 79 28 66 3 3 8 8 0 0.00919 1.000 1.000 14 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(19), FMOD(6), KERA(16), LUM(12) 1512551 60 45 56 25 46 5 3 3 3 0 0.0224 1.000 1.000 15 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(7), ALDH1A2(16), BCMO1(17), RDH5(2) 1670003 42 35 36 13 29 2 1 4 6 0 0.0148 1.000 1.000 16 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 7 SEC61A2(2), SRP19(3), SRP54(4), SRP68(8), SRP72(1), SRP9(1), SRPR(4) 2818836 23 22 23 5 9 0 1 6 7 0 0.201 1.000 1.000 17 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(34), GNAS(33), GNB1(1), PRKACA(3), PRKAR1A(3) 2790154 74 51 70 24 46 11 4 7 6 0 0.0123 1.000 1.000 18 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADM(5), ACADS(6), ECHS1(3), HADHA(6) 2335984 25 24 25 9 15 4 1 4 1 0 0.330 1.000 1.000 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1) 2847454 21 18 21 6 5 2 2 4 6 2 0.329 1.000 1.000 20 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(4), FUT2(4), FUT9(29), GCNT2(7), ST8SIA1(1) 2568161 48 42 45 21 31 4 4 8 1 0 0.152 1.000 1.000 21 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(4) 1438077 9 9 9 5 6 0 0 1 2 0 0.721 1.000 1.000 22 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(9), HLA-DRA(13), HLA-DRB1(5) 1006636 29 24 27 15 23 0 0 3 3 0 0.197 1.000 1.000 23 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(14), LPL(6), NR3C1(7), PPARG(12), RETN(3), RXRA(4), TNF(1) 2489206 47 40 44 17 29 7 0 6 5 0 0.0415 1.000 1.000 24 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(3), CCR3(11), CSF2(2), HLA-DRA(13), HLA-DRB1(5), IL3(3), IL5(4) 1295425 41 29 39 20 33 1 0 4 3 0 0.0602 1.000 1.000 25 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(6), MMP14(3), MMP2(9), MMP9(8), RECK(11), TIMP1(4), TIMP2(2), TIMP3(5), TIMP4(7) 3182420 55 43 53 19 29 4 3 10 9 0 0.0610 1.000 1.000 26 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), CYCS(1), GPD2(3), SDHA(4), SDHC(5), SDHD(2), UQCRC1(4) 2839542 21 18 21 7 13 1 1 4 1 1 0.268 1.000 1.000 27 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 63 48 58 21 36 7 4 9 7 0 0.0100 1.000 1.000 28 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 63 48 58 21 36 7 4 9 7 0 0.0100 1.000 1.000 29 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(2), MYC(5), SP1(5), SP3(1), WT1(10) 2678875 25 21 24 7 14 4 3 1 3 0 0.123 1.000 1.000 30 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(5), PRKCA(9), TGM2(11) 2124288 30 24 29 13 22 2 1 0 5 0 0.0628 1.000 1.000 31 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1942316 11 9 11 9 3 3 1 1 3 0 0.916 1.000 1.000 32 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(16), CCND1(2), CCNE1(4), CCNE2(6), CDK2(1), CDKN1B(2), E2F1(6), E2F2(5), E2F4(3), PRB1(14) 3315113 59 44 57 19 43 0 4 7 5 0 0.0546 1.000 1.000 33 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3), NDUFA12(1), NDUFA13(4) 1700209 16 16 15 8 12 2 1 0 1 0 0.586 1.000 1.000 34 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(19), NR0B2(6), NR1H3(5), NR1H4(14), RXRA(4) 2322057 48 35 48 18 31 7 3 5 2 0 0.0359 1.000 1.000 35 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(1), SQLE(4) 1354168 9 9 9 5 4 1 1 3 0 0 0.710 1.000 1.000 36 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6) 2409018 95 71 78 31 77 4 5 6 3 0 0.00551 1.000 1.000 37 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), MIOX(7), UGDH(1) 3615161 58 46 55 21 33 7 6 5 7 0 0.0290 1.000 1.000 38 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), TYR(11) 4128130 77 53 74 23 49 6 2 5 15 0 0.0127 1.000 1.000 39 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(2), DAG1(9), GNAQ(6), ITPKB(11) 2566827 28 24 26 12 20 0 2 2 4 0 0.164 1.000 1.000 40 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2) 2947162 28 23 28 8 15 5 1 4 3 0 0.226 1.000 1.000 41 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CCND1(2), CDK2(1), CDKN1A(3), CDKN1B(2), CFL1(2), E2F1(6), E2F2(5), MDM2(4), NXT1(2), PRB1(14) 2727321 41 35 40 16 26 3 2 4 6 0 0.145 1.000 1.000 42 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(16), GAD1(14), HDC(25), PNMT(4), TH(11), TPH1(12) 2549058 82 61 77 32 63 5 3 1 10 0 0.00163 1.000 1.000 43 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(13), IARS(10), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1) 4290028 67 51 63 20 45 6 2 7 7 0 0.0552 1.000 1.000 44 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(4), EPO(5), FLT3(38), IGF1(11), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(10), TGFB1(2), TGFB2(4), TGFB3(3) 3515566 93 63 87 34 55 6 6 14 12 0 0.0101 1.000 1.000 45 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(4), PAPSS2(5), SULT1A2(3), SULT1E1(16), SULT2A1(9), SUOX(4) 2605387 41 25 39 14 28 1 0 4 8 0 0.110 1.000 1.000 46 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHB(2), LDHC(7), MPST(2) 2934593 39 31 37 16 28 2 6 2 1 0 0.171 1.000 1.000 47 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), KARS(4) 2952936 21 19 21 8 17 0 0 2 2 0 0.449 1.000 1.000 48 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(3), CSF1(12), IL6(2), LDLR(19), LPL(6) 2287921 42 29 41 20 26 7 2 6 1 0 0.259 1.000 1.000 49 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3), YARS2(2) 3720330 69 50 66 29 44 7 2 5 11 0 0.0529 1.000 1.000 50 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT2(4), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(3) 2140316 31 25 30 17 14 6 3 3 5 0 0.291 1.000 1.000 51 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BAD(4), BCAR1(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN2(6), CAV1(1), CAV3(2), CCND1(2), CCND2(7), CCND3(2), CDC42(2), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), CRK(3), CRKL(2), CTNNB1(17), DIAPH1(10), DOCK1(17), EGF(22), EGFR(26), ELK1(3), ERBB2(10), FARP2(7), FIGF(5), FLNA(23), FLNB(45), FLNC(69), FLT1(42), FN1(28), FYN(8), GRB2(2), GSK3B(3), HGF(30), HRAS(6), IBSP(9), IGF1(11), IGF1R(15), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), JUN(1), KDR(57), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(5), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(9), PRKCG(17), PTK2(7), PXN(2), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF1(14), RELN(90), RHOA(3), ROCK1(6), ROCK2(14), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(55), TNR(84), TNXB(126), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCL(9), VEGFA(5), VEGFB(3), VTN(9), VWF(60), ZYX(8) 156127119 3586 269 3417 1597 2512 253 106 304 386 25 3.37e-08 1.000 1.000 52 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(9), ACTG1(7), CHAD(4), COL11A1(80), COL11A2(51), COL17A1(29), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), COMP(8), DES(9), DSC1(58), DSC2(46), DSC3(50), DSG1(64), DSG2(26), DSG3(68), DSG4(70), FN1(28), GJA1(10), GJA10(18), GJA3(1), GJA4(4), GJA5(11), GJA8(20), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(7), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(12), ITGB4(22), KRT1(22), KRT10(14), KRT12(11), KRT13(13), KRT14(3), KRT15(10), KRT16(10), KRT17(4), KRT18(4), KRT19(3), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(14), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(15), KRT33A(6), KRT33B(4), KRT34(12), KRT35(11), KRT36(18), KRT37(13), KRT38(10), KRT39(16), KRT4(22), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(14), KRT7(5), KRT71(18), KRT72(11), KRT73(18), KRT74(16), KRT75(16), KRT76(17), KRT77(15), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(7), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(4), NES(25), PRPH(1), RELN(90), SPP1(7), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VIM(6), VTN(9), VWF(60) 106337368 3242 260 3064 1417 2373 233 79 224 315 18 1.02e-10 1.000 1.000 53 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(19), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), C5AR1(10), CALCR(19), CALCRL(19), CCKAR(12), CCKBR(14), CGA(1), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(13), CNR2(6), CRHR1(9), CRHR2(5), CTSG(5), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2(13), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHB(9), FSHR(21), GABBR1(9), GABBR2(12), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GABRB1(16), GABRB2(26), GABRB3(25), GABRD(5), GABRE(25), GABRG2(20), GABRG3(10), GABRP(16), GABRQ(12), GABRR1(10), GALR1(5), GALR3(2), GH1(5), GH2(11), GHR(43), GHRHR(12), GHSR(11), GIPR(4), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(16), GNRHR(3), GPR156(15), GPR35(6), GPR50(19), GPR63(9), GPR83(14), GRIA1(52), GRIA2(43), GRIA3(27), GRIA4(26), GRID1(27), GRID2(60), GRIK1(30), GRIK2(31), GRIK3(35), GRIK4(16), GRIK5(12), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRIN3A(50), GRIN3B(5), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM6(32), GRM7(45), GRM8(50), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HRH4(6), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LEP(4), LEPR(31), LHB(1), LHCGR(29), LTB4R(1), LTB4R2(1), MAS1(4), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), MCHR1(4), MCHR2(21), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPBWR1(3), NPBWR2(12), NPFFR1(1), NPFFR2(15), NPY1R(29), NPY2R(13), NPY5R(25), NR3C1(7), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), P2RY1(5), P2RY10(7), P2RY13(4), P2RY14(8), P2RY2(10), P2RY4(2), P2RY6(2), P2RY8(9), PARD3(20), PRL(3), PRLHR(1), PRLR(38), PRSS1(26), PRSS3(7), PTAFR(2), PTGDR(12), PTGER2(7), PTGER3(11), PTGER4(3), PTGFR(21), PTGIR(5), PTH2R(18), RXFP1(19), RXFP2(25), SCTR(8), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SSTR5(4), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), THRA(2), THRB(18), TRHR(24), TRPV1(4), TSHB(7), TSHR(8), UTS2R(1), VIPR1(8), VIPR2(7) 92590785 2913 259 2684 1772 2002 252 102 265 277 15 3.22e-12 1.000 1.000 54 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(4), COL11A1(80), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(26), COL6A3(70), COL6A6(64), DAG1(9), FN1(28), FNDC1(44), FNDC3A(12), FNDC4(5), FNDC5(3), GP5(6), GP6(7), GP9(6), HMMR(5), HSPG2(31), IBSP(9), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(7), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), LAMA1(46), LAMA2(69), LAMA3(72), LAMA4(12), LAMA5(41), LAMB1(16), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), RELN(90), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SPP1(7), SV2A(17), SV2B(27), SV2C(22), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VTN(9), VWF(60) 95453432 2584 258 2464 1108 1866 161 80 180 278 19 9.37e-05 1.000 1.000 55 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY7(13), ADCY8(54), ADCY9(11), ADORA2A(3), ADORA2B(1), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), AGTR1(10), ATP2A1(13), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), ATP2B4(17), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BST1(2), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CCKAR(12), CCKBR(14), CD38(6), CHRM1(5), CHRM2(26), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(12), EDNRB(7), EGFR(26), ERBB2(10), ERBB3(7), ERBB4(59), F2R(8), GNA11(9), GNA14(7), GNA15(7), GNAL(2), GNAQ(6), GNAS(33), GRIN1(11), GRIN2A(107), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), GRPR(7), HRH1(15), HRH2(3), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), LHCGR(29), LTB4R2(1), MYLK(48), MYLK2(13), NOS1(77), NOS3(20), NTSR1(8), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(1), P2RX7(4), PDE1A(44), PDE1B(15), PDE1C(54), PDGFRA(32), PDGFRB(23), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTAFR(2), PTGER3(11), PTGFR(21), PTK2B(12), RYR1(114), RYR2(99), RYR3(96), SLC25A6(2), SLC8A1(35), SLC8A2(14), SLC8A3(46), SPHK1(2), SPHK2(8), TACR1(8), TACR2(9), TACR3(29), TBXA2R(5), TNNC1(2), TNNC2(5), TRHR(24), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 113096253 2866 256 2691 1775 1998 208 103 228 307 22 1.07e-05 1.000 1.000 56 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(4), ARRB2(8), ATF2(6), ATF4(9), BDNF(6), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1F(24), CACNA1G(39), CACNA1H(29), CACNA1I(41), CACNA1S(54), CACNA2D1(17), CACNA2D2(16), CACNA2D3(61), CACNA2D4(26), CACNB1(4), CACNB2(15), CACNB3(3), CACNB4(14), CACNG1(4), CACNG2(11), CACNG3(25), CACNG4(4), CACNG5(13), CACNG6(6), CACNG7(7), CACNG8(1), CASP3(3), CD14(6), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(3), DUSP1(1), DUSP10(9), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(4), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(22), EGFR(26), ELK1(3), ELK4(6), FAS(5), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FLNA(23), FLNB(45), FLNC(69), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), JUN(1), JUND(1), KRAS(7), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(10), MAX(2), MEF2C(5), MKNK1(7), MKNK2(4), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(12), NFATC4(18), NFKB1(6), NFKB2(5), NLK(5), NR4A1(4), NTF3(7), NTRK1(16), NTRK2(11), PAK1(4), PAK2(9), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PPM1A(3), PPM1B(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PPP5C(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PTPN5(13), PTPN7(4), PTPRR(30), RAC2(2), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(5), RASA2(15), RASGRF1(22), RASGRF2(24), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KA6(21), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(5), STMN1(3), TAOK1(11), TAOK2(28), TAOK3(4), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4), ZAK(8) 118737394 2269 255 2178 1338 1473 214 72 216 277 17 0.346 1.000 1.000 57 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(8), ACTN2(21), ACTN4(5), APC(27), APC2(12), ARAF(5), ARHGEF1(2), ARHGEF12(13), ARHGEF4(7), ARHGEF6(11), ARHGEF7(5), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), ARPC5(1), BAIAP2(8), BCAR1(5), BDKRB1(6), BDKRB2(10), CD14(6), CDC42(2), CFL1(2), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(2), CSK(1), CYFIP1(8), CYFIP2(27), DIAPH1(10), DIAPH2(9), DIAPH3(20), DOCK1(17), EGF(22), EGFR(26), EZR(7), F2(13), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(2), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(34), FGFR3(9), FGFR4(12), FN1(28), GIT1(6), GNA12(3), GNA13(1), GSN(8), HRAS(6), IQGAP1(10), IQGAP2(29), IQGAP3(13), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), KRAS(7), LIMK1(5), LIMK2(12), MAP2K2(5), MAPK1(4), MAPK3(3), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(24), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), MYLPF(2), NCKAP1(5), NCKAP1L(44), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PFN4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(10), PTK2(7), PXN(2), RAC2(2), RAF1(12), RDX(4), RHOA(3), ROCK1(6), ROCK2(14), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(4), TIAM1(28), TIAM2(28), VAV1(19), VAV2(5), VAV3(11), VCL(9), WAS(8), WASF1(5), WASF2(6), WASL(4) 115761986 1974 254 1898 1047 1271 155 74 240 222 12 0.00950 1.000 1.000 58 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(3), ACVR2A(5), ACVR2B(3), AMHR2(15), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(7), CCL1(3), CCL11(3), CCL14(3), CCL15(3), CCL16(2), CCL18(1), CCL2(3), CCL20(2), CCL21(2), CCL22(2), CCL23(2), CCL24(3), CCL25(2), CCL26(3), CCL27(2), CCL28(1), CCL7(6), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CD27(3), CD40(4), CD40LG(1), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(8), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), CX3CL1(5), CX3CR1(17), CXCL10(3), CXCL11(1), CXCL12(8), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(6), EDA(2), EDA2R(4), EDAR(9), EGF(22), EGFR(26), EPO(5), EPOR(1), FAS(5), FASLG(15), FLT1(42), FLT3(38), FLT3LG(1), FLT4(31), GDF5(16), GH1(5), GH2(11), GHR(43), HGF(30), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL15(4), IL15RA(6), IL17A(8), IL17B(4), IL17RA(5), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL1RAP(3), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL25(1), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), INHBA(20), INHBB(9), INHBC(13), INHBE(5), KDR(57), KIT(13), KITLG(10), LEP(4), LEPR(31), LIF(3), LIFR(39), LTA(5), LTB(3), MET(23), MPL(9), NGFR(8), OSM(5), OSMR(40), PDGFB(6), PDGFC(17), PDGFRA(32), PDGFRB(23), PF4V1(1), PLEKHO2(5), PPBP(6), PRL(3), PRLR(38), RELT(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(11), TNFRSF14(3), TNFRSF17(7), TNFRSF18(5), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFRSF4(5), TNFRSF6B(2), TNFRSF8(19), TNFRSF9(4), TNFSF10(10), TNFSF11(5), TNFSF12(1), TNFSF13B(3), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(49), TSLP(2), VEGFA(5), VEGFB(3), XCL1(1), XCL2(2), XCR1(7) 74935173 1848 253 1759 963 1283 137 49 162 215 2 0.000306 1.000 1.000 59 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(15), ABLIM1(15), ABLIM2(10), ABLIM3(8), ARHGEF12(13), CDC42(2), CDK5(6), CFL1(2), CXCL12(8), CXCR4(3), DCC(102), DPYSL2(4), DPYSL5(15), EFNA1(1), EFNA2(1), EFNA4(4), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(34), EPHA4(22), EPHA5(7), EPHA6(78), EPHA7(54), EPHA8(24), EPHB1(31), EPHB2(36), EPHB3(17), EPHB4(15), EPHB6(26), FES(8), FYN(8), GNAI1(2), GNAI3(2), GSK3B(3), HRAS(6), ITGB1(7), KRAS(7), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(50), MAPK1(4), MAPK3(3), MET(23), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NGEF(13), NRP1(24), NTN4(19), NTNG1(15), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(10), PLXNA3(17), PLXNB1(23), PLXNB2(17), PLXNB3(7), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTK2(7), RAC2(2), RASA1(5), RGS3(19), RHOA(3), RHOD(2), RND1(6), ROBO1(25), ROBO2(47), ROBO3(19), ROCK1(6), ROCK2(14), SEMA3A(15), SEMA3C(4), SEMA3D(15), SEMA3E(31), SEMA3F(12), SEMA3G(15), SEMA4A(9), SEMA4B(5), SEMA4C(13), SEMA4D(10), SEMA4F(8), SEMA4G(8), SEMA5A(17), SEMA5B(21), SEMA6A(10), SEMA6B(8), SEMA6C(9), SEMA6D(7), SEMA7A(4), SLIT1(16), SLIT2(66), SLIT3(63), SRGAP1(7), SRGAP2(9), SRGAP3(40), UNC5A(13), UNC5B(12), UNC5C(19), UNC5D(37) 82507814 1771 249 1656 918 1210 144 51 171 186 9 0.00171 1.000 1.000 60 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), ANXA6(6), ARRB1(4), ARRB2(8), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(15), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(14), CACNA1A(38), CACNA1B(40), CACNA1C(60), CACNA1D(36), CACNA1E(116), CACNA1S(54), CACNB1(4), CACNB3(3), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CASQ1(8), CASQ2(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(10), GJA4(4), GJA5(11), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(9), GNAI3(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), ITPR1(36), ITPR2(20), ITPR3(12), KCNB1(37), KCNJ3(21), KCNJ5(13), MIB1(6), NME7(5), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SLC8A3(46), USP5(8), YWHAB(1), YWHAQ(3) 78911028 1711 241 1613 1159 1167 148 72 132 183 9 0.307 1.000 1.000 61 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(4), ASH1L(37), CASK(6), CDC42(2), CGN(10), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTTN(5), EPB41(9), EPB41L1(16), EPB41L2(21), EPB41L3(7), EXOC3(6), EXOC4(12), F11R(7), GNAI1(2), GNAI3(2), HCLS1(15), HRAS(6), IGSF5(12), INADL(43), JAM2(11), JAM3(3), KRAS(7), LLGL1(5), LLGL2(16), MAGI1(38), MAGI2(24), MAGI3(12), MLLT4(17), MPDZ(13), MPP5(1), MRAS(2), MYH1(103), MYH10(14), MYH11(31), MYH13(55), MYH14(24), MYH15(64), MYH2(100), MYH3(31), MYH4(100), MYH6(40), MYH7(58), MYH7B(26), MYH8(66), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), OCLN(6), PARD3(20), PARD6A(1), PARD6B(2), PARD6G(4), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), RAB3B(1), RHOA(3), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(16), TJP2(11), TJP3(20), VAPA(2), YES1(4), ZAK(8) 81236785 1615 239 1508 1016 1086 140 45 154 180 10 0.525 1.000 1.000 62 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(5), CADM3(19), CD2(29), CD22(26), CD226(6), CD274(1), CD276(8), CD28(2), CD34(4), CD4(9), CD40(4), CD40LG(1), CD58(1), CD6(12), CD80(4), CD86(25), CD8A(2), CD8B(9), CD99(1), CDH1(6), CDH15(10), CDH2(16), CDH4(40), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(29), CNTN2(16), CNTNAP1(12), CNTNAP2(94), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(45), ITGA6(12), ITGA8(39), ITGA9(15), ITGAL(27), ITGAM(25), ITGAV(11), ITGB1(7), ITGB2(17), ITGB7(7), ITGB8(19), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(15), MPZ(5), MPZL1(2), NCAM1(18), NCAM2(11), NEGR1(9), NEO1(16), NFASC(52), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(60), NRXN2(20), NRXN3(35), OCLN(6), PDCD1(4), PDCD1LG2(3), PTPRC(36), PTPRF(35), PTPRM(8), PVR(2), PVRL1(4), PVRL2(8), PVRL3(5), SDC1(3), SDC2(2), SDC3(8), SDC4(3), SELE(33), SELL(12), SELP(38), SELPLG(11), SIGLEC1(34), SPN(5), VCAM1(17), VCAN(44) 62403116 1470 236 1385 716 998 109 54 156 148 5 3.03e-05 1.000 1.000 63 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADM(1), ARRB1(4), ARRB2(8), ATF1(5), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(15), ATP2A3(15), CACNB3(3), CALCA(4), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CNN1(9), CNN2(3), CORIN(29), CREB3(1), CRHR1(9), DGKZ(9), ETS2(8), FOS(2), GABPA(6), GABPB2(8), GBA2(2), GJA1(10), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(3), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(33), IGFBP1(3), IGFBP2(2), IGFBP3(3), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(13), NFKB1(6), NOS1(77), NOS3(20), OXTR(6), PDE4B(9), PDE4D(8), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(5), PLCG1(9), PLCG2(30), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(3), RGS3(19), RGS4(5), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RLN1(2), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SP1(5), TNXB(126), USP5(8), YWHAB(1), YWHAQ(3) 73822322 1472 233 1396 859 1017 119 53 109 167 7 0.00658 1.000 1.000 64 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(16), CCND1(2), CCND2(7), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(8), CSF2(2), CSF2RA(26), CSF2RB(25), CSF3(4), CSF3R(11), EP300(19), EPO(5), EPOR(1), GH1(5), GH2(11), GHR(43), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL13RA2(6), IL15(4), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(12), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(9), IRF9(8), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), LIF(3), LIFR(39), MPL(9), MYC(5), OSM(5), OSMR(40), PIAS1(7), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIM1(1), PRL(3), PRLR(38), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(6), SPRED2(4), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), STAM(6), STAM2(3), STAT1(5), STAT2(6), STAT3(11), STAT4(26), STAT5A(3), STAT5B(5), STAT6(9), TPO(49), TSLP(2), TYK2(9) 61933245 1194 232 1148 574 774 98 39 131 150 2 0.0210 1.000 1.000 65 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CCR9(6), CCRL2(6), CHML(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(16), CNR1(13), CNR2(6), CX3CR1(17), CXCR3(4), CXCR4(3), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(12), EDNRB(7), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(10), GPR37L1(7), GPR4(5), GPR50(19), GPR6(7), GPR63(9), GPR83(14), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11), LHCGR(29), LTB4R(1), MAS1(4), MC1R(1), MC3R(8), MC4R(1), MC5R(8), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OR10A5(10), OR11A1(6), OR12D3(9), OR1C1(14), OR1F1(9), OR1Q1(6), OR2H1(12), OR5V1(12), OR7A5(2), OR7C1(3), OR8B8(14), OXTR(6), P2RY1(5), P2RY10(7), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(10), P2RY6(2), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), RGR(8), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SUCNR1(10), TBXA2R(5), TRHR(24) 51252604 1318 228 1228 976 893 135 48 138 101 3 0.000301 1.000 1.000 66 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(27), APC2(12), AXIN1(10), AXIN2(5), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CCND1(2), CCND2(7), CCND3(2), CER1(18), CHD8(30), CREBBP(24), CSNK1A1(5), CSNK1A1L(7), CSNK1E(5), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTBP2(6), CTNNB1(17), CTNNBIP1(1), CUL1(3), DAAM1(8), DAAM2(7), DKK1(3), DKK2(19), DKK4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), FBXW11(6), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LEF1(4), LRP5(21), LRP6(14), MAP3K7(1), MAPK10(9), MAPK8(3), MAPK9(4), MMP7(4), MYC(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKD1(9), NKD2(7), NLK(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRICKLE1(11), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), PSEN1(3), RAC2(2), RHOA(3), ROCK1(6), ROCK2(14), RUVBL1(1), SENP2(9), SFRP1(4), SFRP2(9), SFRP4(6), SFRP5(1), SMAD2(5), SMAD3(4), SMAD4(2), SOX17(8), TBL1X(4), TBL1XR1(3), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(8), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6) 67919409 1012 225 969 499 642 88 44 110 122 6 0.0359 1.000 1.000 67 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADK(5), ADSL(6), ADSS(2), ADSSL1(9), AK1(1), AK2(3), AK5(11), AK7(27), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(2), GART(10), GDA(16), GMPR(2), GMPR2(2), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NPR1(17), NPR2(21), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(13), PDE11A(20), PDE1A(44), PDE1C(54), PDE2A(17), PDE3B(6), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PDE9A(13), PFAS(12), PKLR(14), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4), RRM2B(2), XDH(61) 69521955 1220 221 1159 616 833 97 54 113 121 2 0.000624 1.000 1.000 68 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 88 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(16), EGF(22), EGFR(26), GJA1(10), GJD2(5), GNA11(9), GNAI1(2), GNAI3(2), GNAQ(6), GNAS(33), GRB2(2), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), HTR2A(11), HTR2B(2), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAP2K5(5), MAP3K2(8), MAPK1(4), MAPK3(3), MAPK7(4), NPR1(17), NPR2(21), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), PRKX(3), RAF1(12), SOS1(10), SOS2(13), SRC(2), TJP1(16), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12) 54812156 1124 221 1051 619 765 88 44 103 119 5 0.00196 1.000 1.000 69 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(24), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BAD(4), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(16), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(3), EXOC7(8), FASN(26), FBP1(3), FBP2(2), FLOT1(2), FOXO1(6), G6PC(6), G6PC2(3), GCK(16), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(6), IKBKB(4), INPP5D(39), INSR(23), IRS1(5), IRS2(3), IRS4(11), KRAS(7), LIPE(10), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MKNK1(7), MKNK2(4), PCK1(28), PCK2(6), PDE3A(30), PDE3B(6), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PHKA1(26), PHKA2(9), PHKB(11), PHKG1(3), PHKG2(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PKLR(14), PPARGC1A(26), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R3A(64), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(3), PRKX(3), PTPN1(4), PTPRF(35), PYGB(3), PYGL(9), PYGM(14), RAF1(12), RAPGEF1(14), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(4), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SLC2A4(8), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(16), SOS1(10), SOS2(13), SREBF1(5), TRIP10(7), TSC1(9), TSC2(14) 66952032 1062 220 1018 536 693 94 40 109 122 4 0.0271 1.000 1.000 70 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(20), AMY2A(7), AMY2B(14), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(3), ENPP1(13), ENPP3(15), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), G6PC(6), G6PC2(3), GAA(8), GANC(6), GBA(7), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), IFIH1(10), MGAM(190), MOV10L1(25), NUDT5(1), NUDT8(2), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), RAD54B(8), RUVBL2(5), SETX(19), SI(94), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(4), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UXS1(6) 51436338 1079 218 987 476 740 85 44 83 124 3 4.75e-05 1.000 1.000 71 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(32), BDKRB1(6), BDKRB2(10), C1QA(6), C1QB(7), C1QC(10), C1R(17), C1S(20), C2(9), C3(55), C3AR1(6), C4BPA(16), C4BPB(6), C5(23), C5AR1(10), C6(72), C7(49), C8B(47), C8G(1), C9(22), CD46(1), CD55(6), CD59(1), CFB(51), CFH(51), CFI(18), CPB2(1), CR1(53), CR2(36), F10(10), F11(14), F12(1), F13A1(26), F13B(35), F2(13), F2R(8), F3(2), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), KNG1(15), MASP1(20), MASP2(11), MBL2(14), PLAT(5), PLAU(3), PLAUR(4), PLG(36), PROC(11), PROS1(17), SERPINA1(10), SERPINA5(10), SERPINC1(7), SERPIND1(5), SERPINE1(6), SERPINF2(7), SERPING1(14), TFPI(8), THBD(2), VWF(60) 37951820 1214 218 1136 522 856 79 51 110 109 9 7.13e-05 1.000 1.000 72 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(25), CD14(6), CD19(8), CD1A(14), CD1B(14), CD1C(28), CD1D(10), CD1E(29), CD2(29), CD22(26), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD44(5), CD5(8), CD55(6), CD59(1), CD7(2), CD8A(2), CD8B(9), CR1(53), CR2(36), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(26), CSF3(4), CSF3R(11), DNTT(10), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(38), FLT3LG(1), GP5(6), GP9(6), GYPA(10), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL2RA(7), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL7(5), IL7R(37), IL9R(9), ITGA1(23), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGAM(25), ITGB3(25), KIT(13), KITLG(10), MME(25), MS4A1(8), TFRC(4), THPO(10), TNF(1), TPO(49) 34627332 1003 217 931 469 697 53 36 83 129 5 0.000556 1.000 1.000 73 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(8), ACTN2(21), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(13), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), CXCL12(8), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(7), F11R(7), GNAI1(2), GNAI3(2), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), ITK(25), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(17), MMP2(9), MMP9(8), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NCF1(3), NCF2(8), NCF4(8), NOX1(13), NOX3(7), OCLN(6), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAC2(2), RAP1A(1), RAP1B(1), RAPGEF3(14), RAPGEF4(19), RASSF5(4), RHOA(3), RHOH(5), ROCK1(6), ROCK2(14), SIPA1(9), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCAM1(17), VCL(9) 52152760 903 214 862 474 591 69 30 102 106 5 0.0154 1.000 1.000 74 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 69 ARAF(5), CACNA1A(38), CRHR1(9), GNA11(9), GNA12(3), GNA13(1), GNAI1(2), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GNAZ(7), GRIA1(52), GRIA2(43), GRIA3(27), GRID2(60), GRM1(13), GRM5(17), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(6), IGF1(11), IGF1R(15), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), LYN(11), MAP2K2(5), MAPK1(4), MAPK3(3), NOS1(77), NOS3(20), NPR1(17), NPR2(21), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), PRKCA(9), PRKCG(17), PRKG1(15), PRKG2(16), RAF1(12), RYR1(114) 45089065 1179 214 1084 629 821 78 37 101 132 10 0.000145 1.000 1.000 75 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(18), ABCA10(24), ABCA12(80), ABCA13(80), ABCA2(14), ABCA3(16), ABCA4(58), ABCA5(12), ABCA6(30), ABCA7(18), ABCA8(38), ABCA9(22), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(53), ABCB6(2), ABCB7(6), ABCB8(4), ABCB9(7), ABCC1(15), ABCC10(15), ABCC11(19), ABCC12(26), ABCC2(12), ABCC3(32), ABCC4(14), ABCC5(12), ABCC6(31), ABCC8(44), ABCC9(62), ABCD1(1), ABCD2(22), ABCD3(12), ABCD4(3), ABCG1(12), ABCG2(5), ABCG4(7), ABCG5(6), ABCG8(13), CFTR(62), TAP1(2), TAP2(14) 50128219 1039 212 976 586 685 84 35 109 120 6 0.00316 1.000 1.000 76 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(4), AKT3(3), BCAR1(5), CAPN1(5), CAPN10(8), CAPN11(10), CAPN2(6), CAPN3(9), CAPN5(6), CAPN6(14), CAPN7(2), CAPN9(12), CAPNS1(3), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(8), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(7), ITGB2(17), ITGB3(25), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(17), MAPK6(8), MAPK7(4), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PDPK1(5), PIK3R2(6), PTK2(7), PXN(2), RAC2(2), RAP1B(1), RAPGEF1(14), RHO(2), ROCK1(6), ROCK2(14), SDCCAG8(3), SEPP1(13), SHC1(2), SHC3(15), SORBS1(16), SOS1(10), SRC(2), TLN1(12), TNS1(11), VASP(3), VAV2(5), VAV3(11), VCL(9), ZYX(8) 56054100 900 212 873 467 578 72 36 118 92 4 0.0675 1.000 1.000 77 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C1(3), AKR1C2(5), AKR1C3(12), AKR1C4(10), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2F1(13), CYP2S1(14), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(2), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19) 23480328 846 211 759 372 602 52 37 53 99 3 4.93e-09 1.000 1.000 78 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPP5D(39), INPPL1(16), ITPK1(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), OCRL(7), PI4KA(22), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), PRKCA(9), PRKCG(17), SYNJ1(23), SYNJ2(22) 52369739 972 210 900 455 680 52 39 82 113 6 1.18e-05 1.000 1.000 79 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(34), ADCY8(54), ARAF(5), ATF4(9), CACNA1C(60), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(19), GNAQ(6), GRIA1(52), GRIA2(43), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAPK1(4), MAPK3(3), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), RAP1A(1), RAP1B(1), RAPGEF3(14), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21) 40787458 997 210 926 579 669 85 40 95 102 6 0.112 1.000 1.000 80 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ATF4(9), CACNA1C(60), CACNA1D(36), CACNA1F(24), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDC42(2), CGA(1), EGFR(26), ELK1(3), FSHB(9), GNA11(9), GNAQ(6), GNAS(33), GNRH2(2), GNRHR(3), GRB2(2), HBEGF(1), HRAS(6), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), KRAS(7), LHB(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(3), MAPK9(4), MMP14(3), MMP2(9), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLD1(15), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCD(5), PRKX(3), PTK2B(12), RAF1(12), SOS1(10), SOS2(13), SRC(2) 53196332 1019 208 963 628 660 95 46 97 116 5 0.297 1.000 1.000 81 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ASIP(1), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CREB3(1), CREB3L1(7), CREB3L2(11), CREB3L3(13), CREB3L4(7), CREBBP(24), CTNNB1(17), DCT(4), DVL1(1), DVL2(3), DVL3(9), EDN1(9), EDNRB(7), EP300(19), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GNAI1(2), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(33), GSK3B(3), HRAS(6), KIT(13), KITLG(10), KRAS(7), LEF1(4), MAP2K2(5), MAPK1(4), MAPK3(3), MC1R(1), MITF(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), POMC(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(17), PRKX(3), RAF1(12), TCF7(1), TCF7L1(4), TCF7L2(8), TYR(11), TYRP1(9), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6) 45263851 845 208 794 446 530 81 47 88 95 4 0.00495 1.000 1.000 82 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(6), ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(8), CDC42(2), CDH1(6), CREBBP(24), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(30), CTNNA3(39), CTNNB1(17), CTNND1(9), EGFR(26), EP300(19), ERBB2(10), FARP2(7), FER(3), FGFR1(12), FYN(8), IGF1R(15), INSR(23), IQGAP1(10), LEF1(4), LMO7(30), MAP3K7(1), MAPK1(4), MAPK3(3), MET(23), MLLT4(17), NLK(5), PARD3(20), PTPN1(4), PTPN6(5), PTPRB(97), PTPRF(35), PTPRJ(9), PTPRM(8), PVRL1(4), PVRL2(8), PVRL3(5), PVRL4(10), RAC2(2), RHOA(3), SMAD2(5), SMAD3(4), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(16), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(8), TGFBR2(9), TJP1(16), VCL(9), WAS(8), WASF1(5), WASF2(6), WASF3(14), WASL(4), YES1(4) 50962794 768 203 730 386 496 67 33 80 87 5 0.225 1.000 1.000 83 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADK(5), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(11), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(15), ENTPD1(12), ENTPD2(4), FHIT(2), GART(10), GDA(16), GMPS(6), GUCY1A2(21), GUCY1A3(33), GUCY1B3(9), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), IMPDH2(3), ITPA(1), NME1(1), NPR1(17), NPR2(21), NT5E(7), NT5M(2), NUDT2(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(44), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE5A(9), PDE6B(16), PDE6C(25), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(13), PFAS(12), PKLR(14), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4) 54462095 941 202 885 486 640 77 34 92 96 2 0.00292 1.000 1.000 84 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(6), B3GNT1(3), B3GNT2(2), B3GNT6(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), CHPF(4), CHST1(11), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), FUT11(4), FUT8(8), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GANAB(6), GCNT1(6), GCNT3(8), GCNT4(3), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), NDST1(6), NDST2(2), NDST3(25), NDST4(51), OGT(9), RPN2(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GAL1(8), ST6GALNAC1(8), STT3B(5), WBSCR17(46), XYLT1(12), XYLT2(5) 46699723 760 201 730 404 487 66 35 79 93 0 0.0488 1.000 1.000 85 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(6), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), AKAP1(12), AKAP10(3), AKAP11(12), AKAP12(6), AKAP3(17), AKAP4(19), AKAP6(41), AKAP7(3), AKAP8(7), AKAP9(38), ARHGEF1(2), CALM1(1), CALM2(1), CHMP1B(1), GNA11(9), GNA12(3), GNA13(1), GNA14(7), GNA15(7), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(3), GNG10(1), GNG4(3), GNG7(2), GNGT2(5), HRAS(6), ITPR1(36), KCNJ3(21), KRAS(7), PALM2(3), PDE1A(44), PDE1B(15), PDE1C(54), PDE4A(13), PDE4B(9), PDE4C(19), PDE4D(8), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKD3(9), RHOA(3), RRAS(1), SLC9A1(5), USP5(8) 49261196 825 199 787 487 567 62 36 77 83 0 0.453 1.000 1.000 86 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(15), ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), ATM(16), ATR(22), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDC14A(6), CDC14B(3), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(14), CDC6(2), CDC7(3), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(3), DBF4(6), E2F1(6), E2F2(5), E2F3(4), EP300(19), ESPL1(19), FZR1(8), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(22), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), RBL2(6), SFN(2), SKP2(3), SMAD2(5), SMAD3(4), SMAD4(2), SMC1A(3), SMC1B(25), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 57189963 538 199 529 246 308 48 37 86 57 2 0.205 1.000 1.000 87 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(15), ACTN1(8), ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGEF6(11), ARHGEF7(5), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(36), FYN(8), GRB2(2), GRB7(9), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGB3BP(3), MAP2K4(4), MAP2K7(7), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(48), MYLK2(13), P4HB(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PKLR(14), PLCG1(9), PLCG2(30), PTK2(7), RAF1(12), RALA(1), RHO(2), ROCK1(6), ROCK2(14), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(2), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8) 50580065 813 199 773 416 521 68 29 109 84 2 0.118 1.000 1.000 88 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(5), CASP3(3), CD244(10), CD247(4), CD48(8), CSF2(2), FAS(5), FASLG(15), FCER1G(1), FCGR3A(9), FCGR3B(8), FYN(8), GRB2(2), GZMB(4), HLA-A(4), HLA-B(6), HLA-C(2), HLA-E(1), HLA-G(5), HRAS(6), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IFNG(4), IFNGR1(4), IFNGR2(4), ITGAL(27), ITGB2(17), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KLRC1(4), KLRC2(7), KLRC3(8), KLRD1(7), KLRK1(7), KRAS(7), LAT(3), LCK(17), LCP2(8), MAP2K2(5), MAPK1(4), MAPK3(3), MICA(4), MICB(7), NCR1(18), NCR3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK1(4), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRF1(14), PRKCA(9), PRKCG(17), PTK2B(12), PTPN11(10), PTPN6(5), RAC2(2), RAF1(12), SH2D1A(3), SH2D1B(5), SH3BP2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SYK(15), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFSF10(10), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(6), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 46543360 882 197 847 448 570 71 33 95 109 4 0.0572 1.000 1.000 89 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(41), CBL(10), CBLB(21), CBLC(16), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD40LG(1), CD8A(2), CD8B(9), CDC42(2), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(8), GRAP2(7), GRB2(2), HRAS(6), ICOS(3), IFNG(4), IKBKB(4), IL10(2), IL2(4), IL4(1), IL5(4), ITK(25), JUN(1), KRAS(7), LAT(3), LCK(17), LCP2(8), MALT1(8), NCK1(2), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCQ(21), PTPN6(5), PTPRC(36), RASGRP1(11), RHOA(3), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 42739556 722 197 690 348 456 59 28 85 89 5 0.0986 1.000 1.000 90 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(6), CD40(4), CD80(4), CD86(25), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(11), IFNB1(6), IKBKB(4), IKBKE(9), IL12A(4), IL12B(3), IL1B(8), IL6(2), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(10), LY96(4), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(3), TICAM1(8), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(42), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(18), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 37641714 578 196 558 291 373 41 29 71 62 2 0.0334 1.000 1.000 91 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(20), AMY2A(7), AMY2B(14), ENPP1(13), ENPP3(15), G6PC(6), GAA(8), GANAB(6), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), MGAM(190), PGM1(8), PGM3(1), PYGB(3), PYGL(9), PYGM(14), SI(94), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UXS1(6) 24148111 691 196 624 297 485 63 28 48 65 2 5.04e-05 1.000 1.000 92 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(15), ABL2(12), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BAD(4), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CBL(10), CBLB(21), CBLC(16), CDKN1A(3), CDKN1B(2), CRK(3), CRKL(2), EGF(22), EGFR(26), EIF4EBP1(1), ELK1(3), ERBB2(10), ERBB3(7), ERBB4(59), EREG(4), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(6), JUN(1), KRAS(7), MAP2K2(5), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK9(4), MYC(5), NCK1(2), NCK2(5), NRG1(23), NRG2(9), NRG3(24), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(17), PTK2(7), RAF1(12), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(5), TGFA(2) 42394150 732 193 699 363 459 64 31 88 88 2 0.175 1.000 1.000 93 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(5), ACVR2B(3), ACVRL1(12), AMHR2(15), BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BMPR1A(2), BMPR1B(4), BMPR2(7), CHRD(21), COMP(8), CREBBP(24), CUL1(3), DCN(19), E2F4(3), E2F5(3), EP300(19), FST(6), GDF5(16), GDF6(2), GDF7(1), ID1(1), ID2(2), IFNG(4), INHBA(20), INHBB(9), INHBC(13), INHBE(5), LEFTY1(9), LEFTY2(4), LTBP1(46), MAPK1(4), MAPK3(3), MYC(5), NODAL(2), NOG(2), PITX2(6), PPP2CA(1), PPP2CB(2), PPP2R1A(5), PPP2R1B(5), PPP2R2A(5), PPP2R2B(7), PPP2R2C(8), RBL1(14), RBL2(6), RHOA(3), ROCK1(6), ROCK2(14), RPS6KB1(4), RPS6KB2(2), SMAD1(5), SMAD2(5), SMAD3(4), SMAD4(2), SMAD5(2), SMAD6(7), SMAD7(1), SMAD9(12), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNF(1), ZFYVE16(7), ZFYVE9(8) 42268096 637 192 607 287 402 60 30 63 82 0 0.0335 1.000 1.000 94 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), F10(10), F11(14), F12(1), F2(13), F2R(8), F5(39), F8(49), F9(15), FGA(42), FGB(10), FGG(10), KLKB1(26), PROC(11), PROS1(17), SERPINC1(7), SERPING1(14) 18897075 671 190 622 183 500 40 19 54 53 5 0.000597 1.000 1.000 95 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(3), ACVRL1(12), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(7), BUB1(6), CDKL1(1), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MAP3K10(13), MOS(6), NEK1(7), NEK3(2), OCRL(7), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PIM2(5), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKG1(15), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(4), STK11(4), VRK1(1) 47819286 782 190 727 415 532 48 27 77 94 4 0.262 1.000 1.000 96 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(10), AGTR2(10), ATP8A1(33), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(14), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(9), CX3CR1(17), CXCR3(4), CXCR4(3), CXCR6(6), EDNRA(12), EDNRB(7), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(3), GRPR(7), LHCGR(29), MC1R(1), MC2R(5), MC3R(8), MC4R(1), MC5R(8), NMBR(8), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(6), OXTR(6), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), TACR1(8), TACR2(9), TACR3(29), TRHR(24), TSHR(8) 22324664 620 189 582 417 429 53 26 60 52 0 0.000306 1.000 1.000 97 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(1), ACMSD(13), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CAT(8), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADHA(6), KMO(8), KYNU(16), MAOA(4), MAOB(13), SDS(3), TDO2(4), TPH1(12), WARS(5), WARS2(4) 23386276 609 188 573 341 438 39 20 44 65 3 0.0342 1.000 1.000 98 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(9), BAD(4), BCL2(3), CABIN1(17), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(13), CREBBP(24), CSF2(2), CSNK2A1(2), CSNK2B(1), CTLA4(2), EGR2(5), EGR3(4), EP300(19), FCER1A(17), FCGR3A(9), FOS(2), GATA3(9), GATA4(5), GSK3A(1), GSK3B(3), HRAS(6), ICOS(3), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL13(2), IL1B(8), IL2(4), IL2RA(7), IL3(3), IL4(1), IL6(2), ITK(25), KPNA5(2), MAP2K7(7), MAPK14(5), MAPK8(3), MAPK9(4), MEF2A(3), MEF2B(3), MEF2D(6), MYF5(16), NCK2(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB2(5), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PTPRC(36), RELA(4), RPL13A(2), SFN(2), SLA(4), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(5), VAV3(11), XPO5(8) 38810128 562 184 540 312 370 40 24 49 74 5 0.572 1.000 1.000 99 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AKR1A1(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(4), DGAT1(1), DGAT2(7), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), GPAM(6), LCT(54), LIPA(5), LIPC(10), LIPF(17), LIPG(10), LPL(6), MGLL(11), PNLIP(9), PNLIPRP1(10), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10) 24538582 523 181 479 223 350 48 21 51 51 2 1.62e-05 1.000 1.000 100 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(10), AKR1D1(21), ARSD(3), ARSE(5), CARM1(7), CYP11B1(19), CYP11B2(12), CYP19A1(16), HEMK1(4), HSD11B1(14), HSD11B2(2), HSD17B12(4), HSD17B2(13), HSD17B3(5), HSD17B7(1), HSD3B1(15), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(6), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), WBSCR22(2) 20369587 581 180 522 240 395 54 21 40 69 2 3.01e-07 1.000 1.000 101 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(9), ADCY8(54), CACNA1A(38), CACNA1B(40), GNAS(33), GNAT3(5), GNB1(1), GNB3(7), GRM4(22), ITPR3(12), KCNB1(37), PDE1A(44), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), SCNN1A(12), SCNN1B(16), SCNN1G(33), TAS1R1(14), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(5), TAS2R16(10), TAS2R3(2), TAS2R38(19), TAS2R39(14), TAS2R4(4), TAS2R40(6), TAS2R41(13), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(20), TAS2R7(5), TAS2R8(5), TAS2R9(10), TRPM5(14) 24119177 598 180 559 466 402 43 28 60 62 3 0.758 1.000 1.000 102 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(4), ACTA2(5), ACTN2(21), ACTN4(5), DES(9), DMD(41), MYBPC1(29), MYBPC2(21), MYBPC3(16), MYH3(31), MYH6(40), MYH7(58), MYH8(66), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(130), TNNC2(5), TNNI2(2), TNNI3(3), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(7), TPM2(3), TPM3(2), TPM4(3), VIM(6) 26697104 575 180 543 346 371 47 19 53 82 3 0.0194 1.000 1.000 103 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPPL1(16), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(11), MINPP1(1), MIOX(7), OCRL(7), PI4KA(22), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(7), PIP5K1B(21), PIP5K1C(9), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCD3(4), PLCD4(5), PLCE1(60), PLCG1(9), PLCG2(30), PLCZ1(34), SYNJ1(23), SYNJ2(22) 31106789 577 179 543 265 396 31 28 53 66 3 0.000393 1.000 1.000 104 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(15), CARD11(41), CD19(8), CD22(26), CD72(5), CD79A(4), CD81(3), CHUK(2), CR2(36), FCGR2B(3), FOS(2), GSK3B(3), HRAS(6), IKBKB(4), INPP5D(39), JUN(1), KRAS(7), LILRB3(4), LYN(11), MALT1(8), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PTPN6(5), RAC2(2), RASGRP3(12), SYK(15), VAV1(19), VAV2(5), VAV3(11) 31376463 545 179 525 249 345 37 27 60 69 7 0.00870 1.000 1.000 105 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(15), ALG6(2), CCKBR(14), CCR2(17), CCR3(11), CCR5(10), CELSR1(31), CELSR2(26), CELSR3(32), CHRM2(26), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(12), EMR2(6), EMR3(22), F2R(8), FSHR(21), GHRHR(12), GNRHR(3), GPR116(38), GPR132(3), GPR133(16), GPR143(4), GPR17(1), GPR18(5), GPR55(6), GPR61(7), GPR84(9), GRM1(13), GRPR(7), HRH4(6), LGR6(22), LPHN2(50), LPHN3(24), LTB4R2(1), NTSR1(8), OR2M4(14), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1) 28348932 588 177 556 375 387 50 25 62 61 3 0.0585 1.000 1.000 106 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(6), ACADL(5), ACADM(5), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ANGPTL4(5), APOA1(1), APOA2(1), APOA5(5), APOC3(2), AQP7(5), CD36(6), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP27A1(4), CYP4A11(32), CYP4A22(27), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(7), FABP3(1), FABP4(2), FABP7(1), FADS2(4), GK(7), HMGCS2(18), ILK(2), LPL(6), ME1(22), MMP1(14), NR1H3(5), OLR1(6), PCK1(28), PCK2(6), PDPK1(5), PLTP(1), PPARA(8), PPARD(3), PPARG(12), RXRA(4), RXRB(4), RXRG(6), SCD(4), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(6), SLC27A5(10), SLC27A6(34), SORBS1(16), UBC(6), UCP1(5) 27471534 552 177 514 289 376 53 21 38 61 3 0.0456 1.000 1.000 107 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(4), AKT2(8), AKT3(3), BTK(15), CSF2(2), FCER1A(17), FCER1G(1), FYN(8), GAB2(4), GRB2(2), HRAS(6), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(39), KRAS(7), LAT(3), LCP2(8), LYN(11), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK9(4), MS4A2(13), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PRKCA(9), PRKCD(5), PRKCE(7), RAC2(2), RAF1(12), SOS1(10), SOS2(13), SYK(15), TNF(1), VAV1(19), VAV2(5), VAV3(11) 30045277 531 175 511 240 332 42 18 61 74 4 0.00423 1.000 1.000 108 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(15), ATM(16), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(2), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(3), CDH1(6), CDK2(1), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), EP300(19), ESPL1(19), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), HDAC8(5), MAD1L1(7), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MPEG1(6), MPL(9), PCNA(2), PLK1(4), PRKDC(22), PTPRA(9), PTTG1(1), PTTG2(5), RB1(10), RBL1(14), SKP2(3), SMAD4(2), TBC1D8(11), TFDP1(2), TGFB1(2), WEE1(2) 45841062 428 174 421 215 257 41 22 63 43 2 0.366 1.000 1.000 109 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(8), AGTR1(10), AGTR2(10), CMA1(6), COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), REN(12) 10723906 437 172 404 109 339 20 8 25 40 5 0.0512 1.000 1.000 110 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 CPEB1(14), EGFR(26), ERBB2(10), ERBB4(59), ETS1(4), ETS2(8), ETV6(10), ETV7(7), FMN2(87), GRB2(2), KRAS(7), MAPK1(4), MAPK3(3), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), PIWIL1(23), PIWIL2(13), PIWIL3(16), PIWIL4(4), RAF1(12), SOS1(10), SOS2(13), SPIRE1(3), SPIRE2(7) 21390349 467 172 450 213 324 33 14 52 43 1 0.166 1.000 1.000 111 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(5), ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), G6PC2(3), GALM(2), GAPDH(3), GAPDHS(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGAM4(1), PGK1(3), PGK2(36), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 24794019 414 170 379 200 279 29 25 40 41 0 0.00182 1.000 1.000 112 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN1(5), CAPN2(6), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CSF2RB(25), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL3(3), IL3RA(8), IRAK1(5), IRAK2(15), IRAK3(11), IRAK4(3), MYD88(4), NFKB1(6), NFKB2(5), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(5), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(10), TRAF2(2) 35079562 453 170 439 261 281 34 21 58 58 1 0.858 1.000 1.000 113 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(16), EGFR(26), EPHB2(36), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(10), PITX2(6), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), RAF1(12), RGS20(3), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(11), TERF2IP(2) 24252675 469 169 434 260 314 40 20 44 47 4 0.167 1.000 1.000 114 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(23), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(10), CD36(6), CHUK(2), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), G6PC(6), G6PC2(3), IKBKB(4), IRS1(5), IRS2(3), IRS4(11), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), MAPK10(9), MAPK8(3), MAPK9(4), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(28), PCK2(6), POMC(4), PPARA(8), PPARGC1A(26), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKCQ(21), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(8), SOCS3(1), STAT3(11), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(9) 35378840 533 168 513 305 340 49 23 52 69 0 0.581 1.000 1.000 115 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(6), CHUK(2), DAXX(10), ELK1(3), FOS(2), GRB2(2), HRAS(6), IKBKB(4), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(27), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(17), MAP4K5(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK4(17), MAPK6(8), MAPK7(4), MAPK8(3), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MKNK2(4), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(9), RAF1(12), RELA(4), RIPK1(3), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2) 39094051 461 168 450 236 273 50 23 61 53 1 0.515 1.000 1.000 116 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(7), CLK2(8), CLK3(2), COL2A1(44), CPSF1(8), CPSF2(2), CPSF3(3), CSTF1(6), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(4), DDX20(11), DHX15(5), DHX16(9), DHX38(10), DHX8(11), DHX9(11), DICER1(23), DNAJC8(2), FUS(1), GIPC1(6), LSM7(2), METTL3(3), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(2), PAPOLA(4), PHF5A(2), POLR2A(14), PPM1G(2), PRPF18(4), PRPF3(6), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(5), PTBP2(8), RBM17(1), RBM5(10), RNGTT(3), RNMT(9), RNPS1(2), SF3A1(6), SF3A2(6), SF3A3(7), SF3B1(17), SF3B2(11), SF3B4(9), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(2), SNRPF(1), SNRPN(7), SNURF(3), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(9), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6) 45295081 437 168 430 181 252 34 29 59 62 1 0.262 1.000 1.000 117 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AKR1A1(4), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), LCT(54), LIPC(10), LIPF(17), LIPG(10), LPL(6), PNLIP(9), PNLIPRP1(10), PPAP2A(1), PPAP2B(11), PPAP2C(10) 20528996 450 167 410 201 313 39 17 40 39 2 0.000233 1.000 1.000 118 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(12), CAMK4(17), CREBBP(24), CSNK1A1(5), EDN1(9), ELSPBP1(8), F2(13), FGF2(2), GATA4(5), GSK3B(3), HAND1(2), HAND2(5), HRAS(6), IGF1(11), LIF(3), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MEF2C(5), MYH2(100), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NKX2-5(1), NPPA(5), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(12), RPS6KB1(4), SYT1(23) 21336602 426 167 398 237 282 43 16 37 43 5 0.555 1.000 1.000 119 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(4), AKT2(8), AKT3(3), BAD(4), CASP9(2), CDC42(2), HRAS(6), KDR(57), KRAS(7), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(11), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NOS3(20), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R2(5), PRKCA(9), PRKCG(17), PTGS2(13), PTK2(7), PXN(2), RAC2(2), RAF1(12), SH2D2A(5), SHC2(7), SPHK1(2), SPHK2(8), SRC(2), VEGFA(5) 30042899 520 166 501 244 337 38 15 64 63 3 0.0153 1.000 1.000 120 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(12), ALOX12(6), ALOX12B(16), ALOX15(11), ALOX15B(9), ALOX5(14), CBR3(1), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP2U1(2), CYP4A11(32), CYP4A22(27), CYP4F2(17), CYP4F3(26), EPHX2(6), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), LTA4H(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 16489245 573 165 533 329 420 40 10 35 65 3 0.00627 1.000 1.000 121 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), P4HB(3), SLC23A1(6), SLC23A2(4), SLC2A1(5), SLC2A3(7) 10605285 410 164 379 87 318 18 10 24 36 4 0.000227 1.000 1.000 122 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(6), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CYP19A1(16), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), CYP2B6(23), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), PON1(15) 12424580 438 163 408 255 329 24 11 20 52 2 0.00670 1.000 1.000 123 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(4), BDKRB2(10), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(8), FLT1(42), FLT4(31), KDR(57), NOS3(20), PDE2A(17), PDE3A(30), PDE3B(6), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(15), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23) 17323211 423 163 399 237 285 36 10 42 48 2 0.211 1.000 1.000 124 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(4), AKT2(8), AKT3(3), BAD(4), CDC42(2), CDK2(1), CDKN1B(2), CREB3(1), CREB5(9), ERBB4(59), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), MET(23), MYC(5), NOLC1(7), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(10), PTK2(7), PTPN1(4), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SLC2A4(8), SOS1(10), SOS2(13), TSC1(9), TSC2(14), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 32347743 453 163 434 249 276 44 23 58 51 1 0.720 1.000 1.000 125 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(2), BTRC(4), CSNK1A1(5), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(44), GLI3(19), GSK3B(3), HHIP(27), IHH(4), LRP2(108), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), PTCH1(6), PTCH2(18), RAB23(1), SHH(3), SMO(10), STK36(17), SUFU(3), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(8), WNT9A(4), WNT9B(6), ZIC2(3) 25738464 520 161 484 260 355 47 20 50 48 0 0.0277 1.000 1.000 126 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), BCR(14), BLNK(15), BTK(15), CD19(8), CD22(26), CD81(3), CR2(36), CSK(1), DAG1(9), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(39), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), MAP4K1(12), MAPK1(4), MAPK3(3), NFATC1(18), NFATC2(12), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(36), RAF1(12), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 31460302 511 160 487 255 326 39 27 52 62 5 0.0449 1.000 1.000 127 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(7), ACTG2(6), ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), CDC42(2), CFL1(2), FLNA(23), FLNC(69), FSCN1(4), FSCN2(2), FSCN3(13), GDI1(2), GDI2(3), LIMK1(5), MYH2(100), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(6), ROCK2(14), VASP(3), WASF1(5), WASL(4) 20341404 438 160 402 236 303 46 12 39 36 2 0.0237 1.000 1.000 128 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(9), ACSL3(8), ACSL4(5), ACSL5(28), ACSL6(13), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP4A11(32), CYP4A22(27), ECHS1(3), EHHADH(6), GCDH(7), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6) 20936387 404 159 370 166 288 27 23 24 41 1 0.000107 1.000 1.000 129 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ENTPD3(9), ENTPD4(4), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT2(2), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), RRM1(3), RRM2(4), RRM2B(2), TK1(1), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UPB1(14), UPP1(1), UPP2(6), UPRT(1) 34487643 444 159 417 225 286 36 15 64 42 1 0.163 1.000 1.000 130 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(37), ASH2L(5), CARM1(7), CTCFL(21), DOT1L(12), EED(3), EHMT1(11), EHMT2(11), EZH1(10), EZH2(13), FBXO11(7), HCFC1(21), HSF4(1), JMJD4(7), JMJD6(2), KDM6A(3), MEN1(3), MLL3(2), NSD1(21), OGT(9), PAXIP1(3), PPP1CA(3), PPP1CB(5), PPP1CC(2), PRDM2(15), PRDM7(5), PRDM9(51), PRMT1(3), PRMT5(7), PRMT7(4), PRMT8(10), RBBP5(4), SATB1(22), SETD1A(27), SETD2(16), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(8), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(3), WHSC1(10), WHSC1L1(6) 50390913 447 158 433 197 283 51 13 62 38 0 0.387 1.000 1.000 131 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(16), CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG2(1), CCNH(2), CDC25A(8), CDK2(1), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), CREB3(1), CREB3L1(7), CREB3L3(13), CREB3L4(7), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MNAT1(2), MYC(5), MYT1(21), NACA(44), PCNA(2), POLA2(9), POLE(16), POLE2(2), PRIM1(3), RB1(10), RBL1(14), RPA1(3), RPA2(2), TFDP1(2), TFDP2(3), TNXB(126), WEE1(2) 32651895 434 158 425 198 289 37 18 51 37 2 0.0342 1.000 1.000 132 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3) 22350623 380 158 361 169 235 37 15 49 43 1 0.00369 1.000 1.000 133 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(5), EZR(7), FYN(8), HCLS1(15), ITGB1(7), KRT18(4), LY96(4), NCK1(2), NCK2(5), NCL(6), OCLN(6), PRKCA(9), RHOA(3), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(11), TUBB8(12), WAS(8), WASL(4), YWHAQ(3) 22350623 380 158 361 169 235 37 15 49 43 1 0.00369 1.000 1.000 134 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(5), ALAS1(2), ALAS2(6), BLVRA(2), BLVRB(1), COX10(8), COX15(4), CP(14), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UROS(1) 17058931 422 157 377 159 290 33 18 26 53 2 9.41e-06 1.000 1.000 135 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(3), ACTR3(3), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGAP1(3), ARHGAP4(4), ARHGEF11(23), BTK(15), CDC42(2), CFL1(2), GDI1(2), GDI2(3), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(12), LIMK1(5), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PITX2(6), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(6), ROCK2(14), SAG(11), WASF1(5), WASL(4) 29440830 433 157 409 213 286 35 17 55 39 1 0.0305 1.000 1.000 136 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), CARM1(7), COMT(4), DBH(16), DCT(4), DDC(16), ECH1(5), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(15), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NAT6(5), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SH3GLB1(2), TAT(21), TH(11), TPO(49), TYR(11), TYRP1(9), WBSCR22(2) 25297475 443 156 416 241 306 37 22 36 42 0 0.258 1.000 1.000 137 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(5), AKT1(4), APC(27), CAMP(2), CAV3(2), DAG1(9), DLG4(7), EPHB2(36), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(6), PTX3(1), RHO(2), RYR1(114) 19228527 335 156 323 212 223 30 16 26 38 2 0.434 1.000 1.000 138 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 20812840 354 155 323 161 240 28 20 35 31 0 0.000464 1.000 1.000 139 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHB(2), LDHC(7), PDHA1(5), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(3), PGM1(8), PGM3(1), PKLR(14), TPI1(1) 20812840 354 155 323 161 240 28 20 35 31 0 0.000464 1.000 1.000 140 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(3), CREBBP(24), CTBP2(6), DLL1(3), DLL3(7), DLL4(12), DTX1(7), DTX2(2), DTX3(5), DTX3L(6), DTX4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), HDAC1(2), HDAC2(2), HES1(2), JAG1(10), JAG2(10), LFNG(5), MAML1(9), MAML2(7), MAML3(9), MFNG(8), NCOR2(28), NCSTN(5), NOTCH1(9), NOTCH2(26), NOTCH3(27), NOTCH4(63), NUMB(4), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(3) 29318409 364 155 360 211 222 41 13 50 38 0 0.908 1.000 1.000 141 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(36), FBXW7(11), GRAP2(7), GRB2(2), ITK(25), ITPKB(11), LAT(3), LCK(17), LCP2(8), MAPK1(4), NCK1(2), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(9), PTPRC(36), RAF1(12), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), SOS1(10), SOS2(13), VAV1(19), ZAP70(8) 23625534 427 154 407 213 271 33 17 48 55 3 0.215 1.000 1.000 142 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(10), F11(14), F12(1), F13B(35), F2(13), F5(39), F7(7), F8(49), F9(15), FGA(42), FGB(10), FGG(10), LPA(59), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6), SERPINF2(7), VWF(60) 14972071 441 153 419 176 311 27 23 38 40 2 0.00519 1.000 1.000 143 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(4), AKT2(8), AKT3(3), BCR(14), BTK(15), CD19(8), DAPP1(6), FLOT1(2), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(6), PLCG2(30), PPP1R13B(9), PREX1(10), PTPRC(36), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SAG(11), SYK(15), TEC(13), VAV1(19) 22834294 338 152 317 194 217 24 18 37 40 2 0.318 1.000 1.000 144 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(5), CALR(2), CANX(1), CD4(9), CD74(8), CD8A(2), CD8B(9), CIITA(18), CTSS(7), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(7), HLA-DOB(3), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(4), HLA-G(5), HSP90AA1(3), HSP90AB1(8), HSPA5(7), IFI30(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), KIR2DL1(24), KIR2DL3(5), KIR2DL4(5), KIR3DL1(14), KIR3DL2(16), KIR3DL3(5), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LGMN(5), LTA(5), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(14), TAPBP(2) 19638215 363 151 346 217 242 32 14 39 35 1 0.466 1.000 1.000 145 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MIOX(7), OCRL(7), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PLCB1(61), PLCB2(12), PLCB3(4), PLCB4(88), PLCD1(5), PLCG1(9), PLCG2(30) 18985076 398 151 360 174 278 20 17 34 46 3 0.00141 1.000 1.000 146 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), XYLB(6) 10705114 348 150 304 137 246 26 14 18 43 1 0.000190 1.000 1.000 147 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ACAT2(1), ACMSD(13), AFMID(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CARM1(7), CAT(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), DDC(16), ECHS1(3), EHHADH(6), GCDH(7), HAAO(3), HADH(3), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(10), KMO(8), KYNU(16), LCMT1(4), LCMT2(1), LNX1(20), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NFX1(10), OGDH(10), OGDHL(44), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(2) 25767980 436 149 414 215 290 36 19 47 42 2 0.0345 1.000 1.000 148 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(7), ATM(16), ATR(22), BAI1(16), BAX(5), CASP3(3), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG1(2), CCNG2(1), CDK2(1), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(11), IGFBP3(3), MDM2(4), MDM4(2), PERP(3), PPM1D(4), RFWD2(7), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(10), SERPINE1(6), SESN1(2), SESN2(7), SESN3(1), SFN(2), STEAP3(9), THBS1(31), TNFRSF10B(5), TP53I3(3), TP73(6), TSC2(14), ZMAT3(1) 26436248 309 149 302 170 199 25 17 34 33 1 0.665 1.000 1.000 149 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(10), ADAM17(1), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), CASP3(3), CDC42(2), CHUK(2), CSK(1), EGFR(26), F11R(7), GIT1(6), HBEGF(1), IGSF5(12), IKBKB(4), JAM2(11), JAM3(3), JUN(1), LYN(11), MAP2K4(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(3), MAPK9(4), MET(23), NFKB1(6), NFKB2(5), NFKBIA(2), NOD1(10), PAK1(4), PLCG1(9), PLCG2(30), PTPN11(10), PTPRZ1(27), RELA(4), SRC(2), TCIRG1(6), TJP1(16) 29808581 379 149 372 220 226 31 19 52 50 1 0.803 1.000 1.000 150 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAK1(2), BAX(5), BFAR(2), BTK(15), CAD(18), CASP10(10), CASP3(3), CASP8(9), CD7(2), CDK2AP1(2), CSNK1A1(5), DAXX(10), DEDD(2), DEDD2(3), DFFA(2), DIABLO(3), EGFR(26), EPHB2(36), FAF1(9), FAIM2(6), HSPB1(2), IL1A(5), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MET(23), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(17), RALBP1(3), RIPK1(3), ROCK1(6), SMPD1(3), TNFRSF6B(2), TPX2(11), TRAF2(2), TUFM(8) 30548804 376 149 364 219 227 27 19 48 54 1 0.907 1.000 1.000 151 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH4A1(6), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), GAMT(5), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(77), NOS3(20), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), P4HB(3), PYCR1(1), RARS(7), SMS(5) 18768312 349 148 330 182 223 36 17 30 42 1 0.0721 1.000 1.000 152 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(10), B4GALT1(2), B4GALT2(3), G6PC(6), G6PC2(3), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), HSD3B7(5), LALBA(8), LCT(54), MGAM(190), PFKL(3), PFKM(2), PFKP(2), PGM1(8), PGM3(1), RDH11(3), RDH12(2), RDH13(3), RDH14(1), UGP2(1) 16418433 390 148 363 221 290 31 9 34 25 1 0.0791 1.000 1.000 153 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(7), GRIN1(11), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), NOS1(77), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), SYT1(23) 10852964 354 147 331 218 258 29 9 23 33 2 0.225 1.000 1.000 154 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(3), FBP2(2), G6PC(6), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), LALBA(8), LCT(54), MGAM(190), PFKM(2), PFKP(2), PGM1(8), PGM3(1) 13840899 361 146 334 201 269 31 8 30 22 1 0.0655 1.000 1.000 155 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKI(36), DGKQ(7), DGKZ(9), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(6), GPD1(10), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), NAT6(5), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(10), PTDSS2(3), SH3GLB1(2) 27808795 388 146 366 199 247 32 17 40 49 3 0.171 1.000 1.000 156 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(27), AXIN1(10), CCND1(2), CCND2(7), CCND3(2), CSNK1E(5), CTNNB1(17), DVL1(1), DVL2(3), DVL3(9), FBXW2(2), FZD1(5), FZD10(12), FZD2(7), FZD3(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LDLR(19), MAPK10(9), MAPK9(4), MYC(5), PAFAH1B1(6), PLAU(3), PPP2R5C(4), PPP2R5E(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), RHOA(3), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6) 25283138 358 146 348 191 223 34 10 38 53 0 0.215 1.000 1.000 157 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), DUT(1), ENTPD1(12), ITPA(1), NME1(1), NT5E(7), NT5M(2), NUDT2(2), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4), RRM1(3), RRM2(4), TK1(1), TK2(1), TXNRD1(5), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(14), UPP1(1) 24451868 338 145 313 151 214 31 11 51 30 1 0.0137 1.000 1.000 158 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(55), C5(23), C6(72), C7(49), ICAM1(2), IL1A(5), IL6(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELP(38), SELPLG(11), TNF(1), VCAM1(17) 10497617 371 144 336 153 262 12 18 36 38 5 0.000448 1.000 1.000 159 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), COMT(4), DBH(16), DCT(4), DDC(16), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(15), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(21), TH(11), TPO(49), TYR(11) 13462769 357 144 332 197 258 29 15 22 33 0 0.0646 1.000 1.000 160 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPS(5), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CLC(5), CPT1B(9), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(13), DGKQ(7), DGKZ(9), ETNK1(5), GNPAT(1), GPD1(10), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(3), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB2(12), PLCG1(9), PLCG2(30), PPAP2A(1), PPAP2B(11), PPAP2C(10) 21257308 365 143 349 181 238 28 12 37 46 4 0.0138 1.000 1.000 161 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCR(14), BLNK(15), BTK(15), CD19(8), CSK(1), DAG1(9), EPHB2(36), GRB2(2), ITPKB(11), LYN(11), MAP2K2(5), MAPK1(4), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(4), PLCG2(30), PPP1R13B(9), RAF1(12), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 22173972 338 143 326 196 207 28 15 43 42 3 0.775 1.000 1.000 162 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(10), AKR1D1(21), ARSB(3), ARSD(3), ARSE(5), CYP11B1(19), CYP11B2(12), HSD11B1(14), HSD11B2(2), HSD17B2(13), HSD17B3(5), HSD3B1(15), HSD3B2(14), SRD5A1(3), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35) 11606136 346 142 311 151 233 36 15 22 38 2 0.000187 1.000 1.000 163 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(56), B3GALT4(2), CDR1(13), DGKI(36), IL6ST(11), MRPL19(1), PIGK(7), RPL10(4), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL22(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(5), RPL5(8), RPL6(1), RPL7(2), RPLP0(1), RPLP2(1), RPS11(1), RPS13(1), RPS15(1), RPS16(2), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(12), TBC1D10C(6), TSPAN9(4), UBB(1), UBC(6) 22127343 290 142 275 165 183 27 15 31 34 0 0.579 1.000 1.000 164 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 35 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), ELK1(3), FPR1(22), GNA15(7), GNB1(1), HRAS(6), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NCF1(3), NCF2(8), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(56), PLCB1(61), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), RELA(4), SYT1(23) 15711661 340 141 311 142 231 27 12 29 40 1 0.00835 1.000 1.000 165 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(10), ALOX15(11), ALOX5(14), CYP1A2(9), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), HSD3B7(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 10175182 371 141 347 207 271 19 11 19 48 3 0.0279 1.000 1.000 166 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(12), ACADL(5), ACADM(5), ACADSB(6), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), MLYCD(2), SDS(3), SMS(5), UPB1(14) 12394672 282 140 256 115 183 23 10 36 30 0 0.00188 1.000 1.000 167 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(9), DUSP4(4), DUSP8(3), GAB1(8), GCK(16), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(5), MAP2K7(7), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK10(9), MAPK7(4), MAPK8(3), MAPK9(4), MYEF2(4), NFATC3(11), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4), ZAK(8) 21081080 320 139 307 166 214 26 8 36 34 2 0.791 1.000 1.000 168 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(27), AXIN1(10), AXIN2(5), CER1(18), CSNK1A1(5), CTNNB1(17), DACT1(13), DKK1(3), DKK2(19), DKK3(4), DKK4(4), DVL1(1), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(47), MVP(13), NKD1(9), NKD2(7), PIN1(1), PSEN1(3), PTPRA(9), SENP2(9), SFRP1(4), TSHB(7), WIF1(7) 17058518 267 138 256 137 158 31 11 30 35 2 0.385 1.000 1.000 169 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(8), APOA1(1), APOA2(1), CD36(6), CPT1B(9), CREBBP(24), DUSP1(1), DUT(1), EHHADH(6), EP300(19), FABP1(6), HSD17B4(6), HSPA1A(1), JUN(1), LPL(6), MAPK1(4), MAPK3(3), ME1(22), MRPL11(2), MYC(5), NCOA1(9), NCOR1(23), NCOR2(28), NFKBIA(2), NR0B2(6), NR1H3(5), NR2F1(8), NRIP1(10), PDGFA(1), PIK3CA(10), PIK3R1(4), PPARA(8), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(5), TNF(1) 27018423 327 137 317 165 207 31 22 34 29 4 0.465 1.000 1.000 170 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(4), APC(27), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(26), GNA11(9), GNA15(7), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(4), PITX2(6), PTX3(1), RAF1(12), SRC(2) 21993923 296 137 285 176 185 24 16 34 36 1 0.690 1.000 1.000 171 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(6), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(11), MAPK1(4), MAPK3(3), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(4), PIK3R2(6), PIK3R3(2), PIK3R5(17), PRKAA1(1), PRKAA2(32), RHEB(2), RICTOR(13), RPS6(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), STK11(4), TSC1(9), TSC2(14), ULK1(11), ULK2(7), ULK3(1), VEGFA(5), VEGFB(3) 21478262 290 136 275 148 174 26 14 39 35 2 0.418 1.000 1.000 172 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(15), CALM1(1), CALM2(1), ELK1(3), FCER1A(17), FCER1G(1), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP2K4(4), MAP2K7(7), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PAK2(9), PIK3CA(10), PIK3R1(4), PLA2G4A(16), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 17975399 284 135 273 133 174 21 13 37 36 3 0.432 1.000 1.000 173 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(6), GAPDH(3), GAPDHS(3), GCK(16), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(6), LDHAL6B(6), LDHB(2), LDHC(7), MDH1(3), MDH2(4), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PFKL(3), PFKM(2), PFKP(2), PGAM2(3), PGK1(3), PGK2(36), PKLR(14), TNFAIP1(2), TPI1(1) 18119057 284 135 267 156 200 21 15 23 25 0 0.0402 1.000 1.000 174 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(66), GABBR1(9), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(13), GRM2(16), GRM3(66), GRM4(22), GRM5(17), GRM7(45), GRM8(50) 8913247 325 135 300 227 233 23 16 24 28 1 0.159 1.000 1.000 175 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(12), ACADM(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(5), SRM(1), UPB1(14) 11529012 257 135 233 110 164 22 11 32 28 0 0.00794 1.000 1.000 176 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(24), ACACB(23), ACAT2(1), ACOT12(15), ACSS1(2), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PCK2(6), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14) 19964758 291 135 278 153 191 19 19 31 30 1 0.210 1.000 1.000 177 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(16), BMPR1B(4), CCND2(7), CDKN1B(2), DAZL(5), DMC1(11), EGR1(4), ESR2(10), FSHR(21), GJA4(4), INHA(4), LHCGR(29), MLH1(7), NCOR1(23), NR5A1(10), NRIP1(10), PGR(16), PRLR(38), PTGER2(7), SMPD1(3), VDR(3), ZP2(17) 14596097 251 135 228 135 163 18 9 27 33 1 0.700 1.000 1.000 178 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(10), AKR1C4(10), AKR1D1(21), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), HSD3B7(5), LIPA(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SLC27A5(10), SOAT1(3), SOAT2(6), SRD5A1(3) 13517370 287 134 255 123 188 30 22 21 25 1 0.000725 1.000 1.000 179 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(10), AADAC(16), ABAT(12), ACADS(6), ACAT2(1), ACSM1(32), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(8), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADH(3), HADHA(6), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(4), OXCT1(4), OXCT2(5), PDHA1(5), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 17313381 306 134 294 144 208 26 18 23 31 0 0.0246 1.000 1.000 180 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(4), ATF1(5), CAMP(2), CREB3(1), CREB5(9), CREBBP(24), CRKL(2), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(27), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), NTRK1(16), OPN1LW(8), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN11(10), RPS6KA3(2), SHC1(2), SRC(2), TERF2IP(2), TH(11) 21156942 307 134 290 167 204 25 13 34 30 1 0.590 1.000 1.000 181 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C8B(47), C9(22), MASP1(20) 8278889 347 133 313 152 263 15 11 28 26 4 0.00453 1.000 1.000 182 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(7), B3GALNT1(6), B3GALT1(15), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GBGT1(4), GCNT2(7), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGX(2), PIGZ(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12), UGCG(1) 20619833 286 133 278 149 163 31 14 47 30 1 0.137 1.000 1.000 183 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(27), ATP4A(17), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(2), ATP5J(2), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), COX10(8), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA13(4), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFC2(2), NDUFS1(2), NDUFS2(3), NDUFS3(5), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(1), NDUFV2(1), NDUFV3(5), PPA1(1), PPA2(4), SDHA(4), SDHC(5), SDHD(2), TCIRG1(6), UQCRC1(4), UQCRC2(3), UQCRFS1(3) 23869939 283 132 275 141 163 26 16 45 30 3 0.186 1.000 1.000 184 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), GALNT1(4), GALNT10(8), GALNT11(4), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL4(1), GALNTL5(17), GCNT1(6), GCNT3(8), GCNT4(3), OGT(9), ST3GAL1(8), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(46) 13764968 286 132 269 132 194 15 8 33 36 0 0.0787 1.000 1.000 185 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(39), AR(10), ESR1(6), ESR2(10), ESRRA(3), HNF4A(26), NPM1(4), NR0B1(3), NR1D1(1), NR1D2(11), NR1H2(5), NR1H3(5), NR1I2(5), NR1I3(7), NR2C2(1), NR2E1(8), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(10), NR5A2(23), PGR(16), PPARA(8), PPARD(3), PPARG(12), RARA(5), RARB(9), RARG(3), ROR1(15), RORA(8), RORC(15), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3) 17788226 334 132 318 168 232 26 11 26 39 0 0.0451 1.000 1.000 186 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(7), BAD(4), BAK1(2), BAX(5), BCL2(3), BCL2L11(8), BIRC2(6), BIRC3(7), BIRC5(3), BNIP3L(1), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), GZMB(4), HELLS(6), IKBKB(4), IRF1(2), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(14), IRF7(5), JUN(1), LTA(5), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(12), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFSF10(10), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5) 24040874 296 131 291 169 189 30 16 29 31 1 0.705 1.000 1.000 187 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22), MASP1(20), MASP2(11), MBL2(14) 8493602 325 131 296 140 249 13 8 25 26 4 0.00350 1.000 1.000 188 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), AMDHD1(6), AOC2(9), AOC3(9), ASPA(3), CARM1(7), CNDP1(10), DDC(16), FTCD(4), HAL(14), HARS(8), HARS2(4), HDC(25), HEMK1(4), HNMT(3), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), PRPS1(3), PRPS2(3), UROC1(17), WBSCR22(2) 16840005 269 130 258 162 165 24 15 27 36 2 0.438 1.000 1.000 189 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(8), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CDK5(6), F2(13), FYN(8), GNA11(9), GNAI1(2), GNB1(1), GRB2(2), HRAS(6), JAK2(8), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), MAPT(10), MYLK(48), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), SYT1(23) 17336401 273 129 259 163 168 22 13 34 34 2 0.767 1.000 1.000 190 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(12), ALOX12(6), ALOX15(11), ALOX5(14), CBR3(1), CYP4F2(17), CYP4F3(26), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(12), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(4), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(49) 11883679 330 128 321 182 229 31 5 25 39 1 0.0174 1.000 1.000 191 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(10), OGDHL(44), PIPOX(7), PLOD1(6), PLOD2(7), PLOD3(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SETD1A(27), SETD7(2), SETDB1(10), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2) 24660651 310 127 299 148 202 27 16 39 25 1 0.0714 1.000 1.000 192 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(3), ACTR3(3), AKT1(4), ANGPTL2(3), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(15), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), MAPK1(4), MAPK3(3), NR1I3(7), PAK1(4), PDE3A(30), PDE3B(6), PI3(6), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(4), RIPK3(10), VASP(3) 20315694 276 127 258 129 187 23 12 24 29 1 0.0142 1.000 1.000 193 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(21), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), SOAT2(6), SRD5A1(3) 9931614 250 126 221 97 169 20 15 22 23 1 0.000181 1.000 1.000 194 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(1), DHX58(3), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), FPGS(3), GGH(4), IFIH1(10), MOV10L1(25), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4) 26610983 279 126 269 157 177 19 17 27 38 1 0.701 1.000 1.000 195 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(4), CRK(3), CRKL(2), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(30), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K2(5), MAP4K1(12), MAPK1(4), MAPK3(3), MAPK8(3), MET(23), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAF1(12), RAP1A(1), RAP1B(1), RASA1(5), SOS1(10), SRC(2), STAT3(11) 17944707 249 126 240 135 144 24 10 42 27 2 0.936 1.000 1.000 196 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(4), AKT2(8), AKT3(3), ARHGEF11(23), BCL2(3), CDC42(2), DLG4(7), GNA13(1), LPA(59), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(3), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PI3(6), PIK3CB(10), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RDX(4), ROCK1(6), ROCK2(14), SERPINA4(22), SRF(3), TBXA2R(5) 20876814 273 126 260 152 157 23 11 45 37 0 0.832 1.000 1.000 197 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCL11(3), CCR3(11), CFL1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), LIMK1(5), MAPK1(4), MAPK3(3), MYL2(9), NOX1(13), PIK3C2G(56), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2(7), RAF1(12), ROCK2(14) 10337466 265 125 238 91 182 15 7 35 26 0 0.000884 1.000 1.000 198 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ARG2(2), ASL(9), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), EPRS(13), GAMT(5), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(2), NOS1(77), NOS3(20), OAT(4), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), PRODH(2), PYCR1(1), PYCR2(1), RARS(7), RARS2(4) 15270113 270 125 256 143 181 26 11 19 31 2 0.162 1.000 1.000 199 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(7), ARRB2(8), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CLCA1(8), CLCA2(9), CLCA4(30), CNGA3(25), CNGA4(18), CNGB1(23), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(11), PDC(6), PDE1C(54), PRKACA(3), PRKACB(4), PRKACG(10), PRKG1(15), PRKG2(16), PRKX(3) 12882005 299 125 279 162 201 24 9 31 34 0 0.133 1.000 1.000 200 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(4), AKT2(8), AKT3(3), BRD4(24), CAP1(2), CBL(10), CDC42(2), F2RL2(8), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), LNPEP(11), MAPK1(4), MAPK3(3), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PTPN1(4), RAF1(12), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SERPINB6(5), SFN(2), SHC1(2), SLC2A4(8), SORBS1(16), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 24841631 273 125 266 139 151 34 15 43 29 1 0.599 1.000 1.000 201 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 32 BLNK(15), BTK(15), CALM1(1), CALM2(1), CD79A(4), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP3K1(4), MAPK14(5), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), RAF1(12), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 15779976 245 123 235 121 157 17 9 29 31 2 0.524 1.000 1.000 202 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(6), C1QB(7), C1R(17), C1S(20), C2(9), C3(55), C5(23), C6(72), C7(49), C9(22) 6873265 280 123 253 119 212 11 7 24 22 4 0.00713 1.000 1.000 203 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(7), APAF1(7), ARHGDIB(4), BAG4(3), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), GSN(8), LMNA(5), LMNB1(2), LMNB2(4), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK8(3), MDM2(4), NFKB1(6), NFKBIA(2), NUMA1(11), PAK2(9), PRKCD(5), PRKDC(22), PSEN1(3), PSEN2(2), PTK2(7), RASA1(5), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2) 29446534 256 123 250 134 123 28 16 48 38 3 0.690 1.000 1.000 204 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(24), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(4), LDHA(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(28), PDHA1(5), PDHA2(20), PDHB(1), PKLR(14) 15779632 244 123 232 119 166 17 13 25 22 1 0.119 1.000 1.000 205 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(8), GRB2(2), HRAS(6), JUN(1), LAT(3), LCK(17), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(4), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PTPN7(4), RAF1(12), RASA1(5), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(8) 19831741 265 123 256 127 162 29 10 32 29 3 0.480 1.000 1.000 206 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(3), CHUK(2), DAXX(10), EGF(22), EGFR(26), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(6), IKBKB(4), JUN(1), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(7), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), NFKB1(6), NFKBIA(2), PPP2CA(1), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(17), PRKCH(10), PRKCQ(21), RAF1(12), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 20536783 273 122 266 166 166 25 9 30 43 0 0.848 1.000 1.000 207 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), ELAVL1(1), FLT1(42), FLT4(31), HIF1A(4), HRAS(6), KDR(57), NOS3(20), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PXN(2), SHC1(2), VHL(4) 14545807 229 121 215 114 149 21 3 29 26 1 0.368 1.000 1.000 208 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(27), ATF2(6), AXIN1(10), BMP10(14), BMP2(7), BMP4(5), BMP5(33), BMP7(5), BMPR1A(2), BMPR2(7), CHRD(21), CTNNB1(17), DVL1(1), FZD1(5), GATA4(5), GSK3B(3), MAP3K7(1), MEF2C(5), MYL2(9), NKX2-5(1), NOG(2), NPPA(5), NPPB(6), RFC1(5), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), WNT1(2) 15445587 233 120 215 103 149 21 10 21 32 0 0.194 1.000 1.000 209 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(1), EGFR(26), ELK1(3), GNAS(33), GNB1(1), GRB2(2), HRAS(6), IGF1R(15), ITGB1(7), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(30), RAF1(12), RPS6KA1(11), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(11) 13708902 253 120 242 113 153 29 13 39 19 0 0.111 1.000 1.000 210 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(7), ENPP7(6), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(3), SMPD2(2), SMPD3(9), SMPD4(6), SPHK1(2), SPHK2(8), SPTLC1(2), SPTLC2(8), UGCG(1), UGT8(8) 15130294 257 120 250 166 178 17 6 30 26 0 0.840 1.000 1.000 211 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), HRH1(15), HRH2(3), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR4(14), HTR5A(19), HTR6(3), HTR7(11) 10392292 276 120 252 212 179 32 11 27 25 2 0.0806 1.000 1.000 212 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(48), NCF2(8), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLD1(15), PPP1R12B(10), RALBP1(3), RPS6KB1(4), TRIO(23), VAV1(19), WASF1(5) 14739970 221 120 210 118 138 17 9 27 28 2 0.556 1.000 1.000 213 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(19), CALCR(19), CALCRL(19), CD97(7), CRHR1(9), CRHR2(5), ELTD1(27), EMR1(35), EMR2(6), GHRHR(12), GIPR(4), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(50), LPHN3(24), SCTR(8), VIPR1(8), VIPR2(7) 11248894 298 119 277 181 213 21 9 16 39 0 0.101 1.000 1.000 214 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(12), ACAA1(6), ACAA2(1), ACADM(5), ACADS(6), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), AOX1(29), AUH(2), BCAT1(13), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HADHB(6), HIBADH(5), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), OXCT2(5), PCCA(5), PCCB(3) 18392272 237 118 227 111 154 20 14 25 24 0 0.220 1.000 1.000 215 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(3), FUCA1(3), GALNS(5), GBA(7), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NAGLU(4), NEU1(6), NEU2(19), NEU3(5), NEU4(16), SPAM1(28) 14580267 254 118 249 133 178 22 5 25 23 1 0.184 1.000 1.000 216 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(3), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(12), ARHGEF1(2), ARHGEF11(23), ARHGEF5(17), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), BAIAP2(8), CFL1(2), DIAPH1(10), GSN(8), LIMK1(5), MYL2(9), MYLK(48), OPHN1(4), PIP5K1A(7), PIP5K1B(21), PPP1R12B(10), ROCK1(6), SRC(2), TLN1(12), VCL(9) 19184854 249 118 239 123 175 14 10 25 25 0 0.0772 1.000 1.000 217 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(6), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(13), RFT1(5), RPN2(4), ST6GAL1(8), STT3B(5) 18038343 210 117 203 110 124 22 14 22 27 1 0.257 1.000 1.000 218 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(2), BLVRB(1), CP(14), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35), UROS(1) 11766354 231 117 209 104 158 20 12 15 24 2 0.0382 1.000 1.000 219 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(6), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), PPARA(8), RELA(4), TIRAP(1), TLR10(13), TLR2(15), TLR3(11), TLR4(42), TLR6(7), TLR7(17), TLR9(18), TOLLIP(1), TRAF6(4) 15464628 209 117 202 102 138 19 9 23 20 0 0.161 1.000 1.000 220 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(6), JUN(1), MAPK3(3), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RAF1(12), RPS6KA3(2), SYT1(23) 14507453 245 116 232 127 153 26 13 28 24 1 0.539 1.000 1.000 221 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(55), C5(23), C6(72), C7(49), C9(22) 4796342 221 115 195 88 165 6 6 21 19 4 0.0108 1.000 1.000 222 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 AGXT(12), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), ATP6V0C(3), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(9), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), MAOA(4), MAOB(13), PEMT(3), PISD(2), PLCB2(12), PLCG1(9), PLCG2(30), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5) 17475585 249 115 242 154 167 19 12 19 32 0 0.467 1.000 1.000 223 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(4), APC(27), AXIN1(10), CCND1(2), CD14(6), CTNNB1(17), DVL1(1), FZD1(5), GJA1(10), GNAI1(2), GSK3B(3), IRAK1(5), LBP(10), LEF1(4), LY96(4), MYD88(4), NFKB1(6), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4), TIRAP(1), TLR4(42), TOLLIP(1), WNT1(2) 12985566 190 115 181 100 115 17 11 24 21 2 0.717 1.000 1.000 224 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(7), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(14), EDN1(9), EDNRA(12), EDNRB(7), HPGD(2), HSD11B1(14), HSD11B2(2), PLA2G4A(16), PRL(3), PTGDR(12), PTGDS(4), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), PTGIS(18), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16) 8729408 222 115 213 87 151 23 6 20 21 1 4.59e-05 1.000 1.000 225 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 22 ATF2(6), BCR(14), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), LYN(11), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8IP3(9), PAPPA(59), RPS6KA1(11), RPS6KA3(2), SHC1(2), SOS1(10), SYK(15), VAV1(19), VAV2(5), VAV3(11) 13063413 214 115 205 144 146 16 4 21 25 2 0.973 1.000 1.000 226 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(5), AARS2(3), ABAT(12), ACY3(4), ADSL(6), ADSS(2), ADSSL1(9), AGXT(12), ASL(9), ASNS(9), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(9), DLAT(4), DLD(3), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(5), PDHA2(20), PDHB(1) 15732636 223 114 215 124 150 22 12 18 21 0 0.304 1.000 1.000 227 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(12), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CYP2C19(40), CYP2C9(41), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 13220609 199 113 187 118 124 21 14 18 22 0 0.791 1.000 1.000 228 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(5), AARS2(3), CARS(9), CARS2(4), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(8), HARS2(4), IARS(10), IARS2(18), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(4), SARS(5), SARS2(3), TARS(5), TARS2(8), VARS(16), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2) 23310231 227 113 215 126 133 25 9 26 32 2 0.700 1.000 1.000 229 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(4), ACTN1(8), ACTN2(21), BCAR1(5), BCR(14), CAPN1(5), CAPNS1(3), CAPNS2(1), CAV1(1), CRKL(2), CSK(1), FYN(8), GRB2(2), HRAS(6), ITGA1(23), ITGB1(7), JUN(1), MAP2K2(5), MAPK1(4), MAPK3(3), MAPK8(3), PPP1R12B(10), PTK2(7), PXN(2), RAF1(12), RAP1A(1), ROCK1(6), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(9), ZYX(8) 19573048 208 113 204 113 108 27 13 32 27 1 0.575 1.000 1.000 230 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFAT5(11), PDE6A(15), PDE6B(16), PDE6C(25), PDE6D(2), PDE6G(2), SLC6A13(31), TF(16) 15180327 230 113 215 135 158 11 6 19 36 0 0.184 1.000 1.000 231 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(25), CD2(29), CD33(21), CD5(8), CD7(2), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(25), TLR2(15), TLR4(42), TLR7(17), TLR9(18) 7912106 234 112 217 116 166 21 11 14 22 0 0.000181 1.000 1.000 232 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(5), CAPN2(6), CAPNS1(3), CAPNS2(1), CXCR3(4), EGF(22), EGFR(26), HRAS(6), ITGA1(23), ITGB1(7), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12) 13847150 219 112 210 129 143 14 10 22 30 0 0.552 1.000 1.000 233 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), UCHL1(6), UCHL3(2), UGDH(1), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16), UGT2B15(31), UGT2B4(35) 7546020 191 112 166 93 136 17 11 8 18 1 0.0536 1.000 1.000 234 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TAT(21), TPO(49) 9341657 214 112 208 146 148 22 7 12 25 0 0.531 1.000 1.000 235 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(15), DLG4(7), EPHB2(36), F2(13), F2RL1(9), F2RL2(8), F2RL3(5), JUN(1), MAP2K5(5), MAPK1(4), MAPK7(4), MAPK8(3), MYEF2(4), PLD1(15), PLD2(8), PLD3(1), PTK2(7), RAF1(12), RASAL1(18), SRC(2), TEC(13), VAV1(19) 11671726 209 112 201 142 123 23 6 31 23 3 0.959 1.000 1.000 236 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(6), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), AOX1(29), BCAT1(13), BCKDHA(1), BCKDHB(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), HIBADH(5), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), PCCA(5), PCCB(3), SDS(3) 15396124 206 112 196 97 135 16 10 22 23 0 0.234 1.000 1.000 237 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(11), ITGB3(25), MAPK1(4), MAPK3(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCB1(61), PRKCA(9), PTK2(7), SMPD1(3), SMPD2(2), SPHK1(2), SRC(2) 11555407 217 111 207 87 150 13 8 24 21 1 0.00491 1.000 1.000 238 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(12), ACACA(24), ACACB(23), ACADM(5), ACAT2(1), ACSS1(2), ACSS2(5), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SUCLG1(4), SUCLG2(3) 16979753 193 111 185 103 115 15 17 23 23 0 0.499 1.000 1.000 239 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(13), F2R(8), F2RL3(5), GNAI1(2), GNB1(1), HRAS(6), ITGA1(23), ITGB1(7), MAPK1(4), MAPK3(3), PLA2G4A(16), PLCB1(61), PRKCA(9), PTGS1(20), PTK2(7), RAF1(12), SRC(2), SYK(15), TBXAS1(16) 10041621 230 111 216 99 152 19 7 26 25 1 0.0373 1.000 1.000 240 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), AOC2(9), AOC3(9), ASPA(3), CNDP1(10), DDC(16), HAL(14), HARS(8), HDC(25), HNMT(3), MAOA(4), MAOB(13), PRPS1(3), PRPS2(3) 10368931 194 110 183 111 119 14 10 20 30 1 0.289 1.000 1.000 241 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), NAT6(5), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(21), TPO(49) 14603732 224 110 218 158 154 21 11 14 24 0 0.952 1.000 1.000 242 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(37), ACE2(6), AGT(8), AGTR1(10), AGTR2(10), ANPEP(25), CMA1(6), CPA3(23), CTSA(4), CTSG(5), ENPEP(46), LNPEP(11), MAS1(4), MME(25), NLN(5), REN(12), THOP1(6) 8991146 243 110 227 124 169 20 11 14 28 1 0.0266 1.000 1.000 243 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(7), ITGB2(17), SELE(33), SELL(12), SELP(38) 6733714 211 110 199 83 153 7 6 18 25 2 0.00690 1.000 1.000 244 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(10), IL13RA1(4), IL2RG(3), IL4(1), IL4R(18), INPP5D(39), JAK1(7), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(4), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(9), TYK2(9) 15692547 224 110 213 108 146 17 9 29 22 1 0.338 1.000 1.000 245 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(34), AKT1(4), BAD(4), BAX(5), BCL2(3), CSF2RB(25), IGF1(11), IGF1R(15), IL3(3), IL3RA(8), KIT(13), KITLG(10), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 9343573 176 109 168 103 111 19 11 16 18 1 0.521 1.000 1.000 246 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(4), BAD(4), BCL2(3), CBL(10), CFLAR(5), CRKL(2), E2F1(6), FOS(2), GRB2(2), HRAS(6), IL2RA(7), IL2RB(12), IL2RG(3), IRS1(5), JAK1(7), JAK3(11), MAPK1(4), MAPK3(3), MYC(5), NMI(4), PIK3CA(10), PIK3R1(4), PPIA(1), PTPN6(5), RAF1(12), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 15355772 178 109 173 104 100 22 11 24 20 1 0.847 1.000 1.000 247 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(10), EGF(22), EGFR(26), GRB2(2), HRAS(6), MAPK1(4), MAPK3(3), PTPRB(97), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(2), SRC(2) 10311862 228 109 212 103 152 21 6 24 25 0 0.309 1.000 1.000 248 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(16), CARM1(7), CCND1(2), CREBBP(24), EP300(19), ERCC3(6), ESR1(6), GRIP1(13), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), MEF2C(5), NCOR2(28), NR0B1(3), NRIP1(10), PELP1(14), POLR2A(14), TBP(4) 19402795 210 108 207 92 134 12 12 34 18 0 0.175 1.000 1.000 249 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(13), DIAPH1(10), FYN(8), GSN(8), HRAS(6), ITGA1(23), ITGB1(7), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PIK3CA(10), PIK3R1(4), PTK2(7), PXN(2), RAF1(12), ROCK1(6), SHC1(2), SRC(2), TLN1(12) 15559140 196 108 184 95 120 16 8 30 21 1 0.407 1.000 1.000 250 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), ADC(5), AGMAT(4), ALDH18A1(8), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(9), ASS1(8), CPS1(29), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(5), SRM(1) 12448901 174 108 168 94 96 17 10 23 28 0 0.345 1.000 1.000 251 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(7), ACTG2(6), ADCY3(3), ADCY9(11), AK1(1), ARF4(3), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(33), PDIA4(5), PLCG1(9), PLCG2(30), PRKCA(9), SEC61A1(3), SEC61A2(2), TRIM23(2) 15808781 216 108 208 128 142 12 10 24 28 0 0.443 1.000 1.000 252 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(6), CDC42(2), DAXX(10), DDIT3(3), ELK1(3), GRB2(2), HMGN1(3), HRAS(6), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MAX(2), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MKNK1(7), MYC(5), PLA2G4A(16), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(4), TGFB3(3), TRAF2(2) 15328745 186 108 181 75 115 16 7 26 22 0 0.117 1.000 1.000 253 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(53), CR2(36), FCGR2B(3), HLA-DRA(13), HLA-DRB1(5), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36) 6426148 196 107 186 78 127 15 7 15 27 5 0.0269 1.000 1.000 254 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(5), GHR(43), GRB2(2), HRAS(6), INSR(23), IRS1(5), JAK2(8), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTPN6(5), RAF1(12), RPS6KA1(11), SHC1(2), SLC2A4(8), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(5) 13808726 191 107 181 96 116 17 12 25 20 1 0.369 1.000 1.000 255 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(26), EEF1A2(10), EEF1B2(1), EEF1D(7), EEF1G(6), EEF2(3), EEF2K(6), EIF1AX(3), EIF1AY(1), EIF2AK1(4), EIF2AK2(6), EIF2AK3(13), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G3(19), EIF5(2), EIF5B(4), ETF1(2), GSPT2(9), PABPC1(5), PABPC3(8), PAIP1(9), SLC35A4(4) 18614061 187 107 186 95 107 24 13 19 24 0 0.675 1.000 1.000 256 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(12), STON1(22), TAF1(15), TAF13(1), TAF1L(57), TAF2(9), TAF4(11), TAF4B(7), TAF5L(4), TAF6(4), TAF6L(4), TAF7(3), TAF7L(12), TAF9(3), TAF9B(1), TBPL1(1), TBPL2(8) 15433182 206 106 201 90 140 14 8 25 19 0 0.280 1.000 1.000 257 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(27), ATP4B(1), ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(13), ATP7B(23), COX10(8), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1), PPA2(4), SDHA(4), SHMT1(2), UQCRC1(4), UQCRFS1(3) 16344614 198 106 196 119 116 12 18 29 21 2 0.800 1.000 1.000 258 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(27), AXIN1(10), CREBBP(24), CTNNB1(17), DVL1(1), EP300(19), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(4), PITX2(6), TRRAP(47), WNT1(2) 14184657 170 106 164 93 91 16 13 24 25 1 0.890 1.000 1.000 259 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(12), ACACA(24), ACADL(5), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), LDHA(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SDS(3), SUCLG1(4), SUCLG2(3) 14168861 177 106 169 79 112 13 12 23 17 0 0.164 1.000 1.000 260 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(4), AKT2(8), AKT3(3), BAD(4), BTK(15), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(10), IGFBP1(3), INPP5D(39), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 14749762 192 106 179 83 121 16 11 25 18 1 0.211 1.000 1.000 261 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(12), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(12), DLD(3), DMGDH(17), GAMT(5), GARS(6), GATM(6), GCAT(4), GLDC(6), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(3), PHGDH(5), PIPOX(7), PISD(2), PSAT1(4), PSPH(2), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SARDH(20), SARS(5), SARS2(3), SDS(3), SHMT1(2), SHMT2(3), TARS(5), TARS2(8) 17771881 241 105 235 150 165 18 10 15 33 0 0.553 1.000 1.000 262 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(4), BAX(5), BCL2(3), BCL2A1(2), BCL2L2(3), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(1), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKE(9), LTA(5), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(17), RIPK1(3), TFG(1), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4) 18464851 204 104 201 131 127 19 9 24 24 1 0.972 1.000 1.000 263 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(10), ABAT(12), ACADS(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(20), PDHB(1), SDS(3) 11044883 181 104 172 74 116 17 7 20 21 0 0.00967 1.000 1.000 264 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(5), CRK(3), CXCL12(8), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(6), MAPK1(4), MAPK3(3), NFKB1(6), PIK3C2G(56), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), PTK2(7), PTK2B(12), PXN(2), RAF1(12), RELA(4) 11370108 172 104 156 97 113 13 6 25 14 1 0.740 1.000 1.000 265 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CMBL(5), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), PON1(15), PON2(3), PON3(6) 7664834 202 104 191 75 145 12 6 12 26 1 3.57e-05 1.000 1.000 266 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), CAMP(2), CASP3(3), CERK(1), CREB3(1), CREB5(9), DAG1(9), EPHB2(36), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4) 12137477 163 104 158 98 106 11 8 16 21 1 0.862 1.000 1.000 267 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), ATF1(5), CDC42(2), CREB3(1), CREB5(9), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(13), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(7), MKNK2(4), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4) 14189558 177 104 170 102 113 17 3 23 21 0 0.719 1.000 1.000 268 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(26), ELK1(3), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PAK1(4), PRKCA(9), PTK2(7), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23) 13740076 191 103 181 116 119 18 10 25 18 1 0.950 1.000 1.000 269 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(13), BCAT2(1), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), ILVBL(5), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14), VNN1(7) 7364067 196 103 174 56 143 11 3 21 18 0 4.84e-06 1.000 1.000 270 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 218 102 208 104 140 22 11 21 23 1 0.114 1.000 1.000 271 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(17), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 218 102 208 104 140 22 11 21 23 1 0.114 1.000 1.000 272 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(4), AVP(1), CABIN1(17), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), HDAC5(6), IGF1(11), IGF1R(15), INSR(23), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1), NFATC1(18), NFATC2(12), PIK3CA(10), PIK3R1(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(23) 14860672 204 102 192 111 134 19 10 23 17 1 0.371 1.000 1.000 273 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), GLCE(8), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(51) 8709189 176 102 171 96 112 13 8 20 23 0 0.238 1.000 1.000 274 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(6), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ATP6V0C(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(11), GCDH(7), HADHA(6), PLOD1(6), PLOD2(7), PLOD3(5), SDS(3), SHMT1(2), SHMT2(3), TMLHE(2) 15709863 176 102 168 91 113 18 7 21 16 1 0.220 1.000 1.000 275 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(34), ARHGEF1(2), F2(13), F2R(8), F2RL3(5), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(4), PLCB1(61), PPP1R12B(10), PRKCA(9), PTK2B(12), ROCK1(6) 11017213 188 102 177 91 124 15 8 23 16 2 0.181 1.000 1.000 276 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(3), CDK2(1), CDT1(3), DIAPH2(9), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), NACA(44), PCNA(2), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(3), RFC1(5), RFC2(4), RFC3(1), RPA1(3), RPA2(2), RPA4(2), UBB(1), UBC(6) 21570075 180 101 177 112 122 13 7 25 13 0 0.889 1.000 1.000 277 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), GNAS(33), GRB2(2), HRAS(6), MAPK1(4), MAPK14(5), MAPK3(3), PIK3CA(10), PIK3R1(4), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RPS6KA1(11), RPS6KA5(7), SOS1(10) 12178266 193 100 186 107 123 20 9 19 21 1 0.703 1.000 1.000 278 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(10), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), FUK(8), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), HSD3B7(5), KHK(2), LHPP(1), MPI(2), MTMR1(6), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(6), PFKFB3(5), PFKFB4(8), PFKL(3), PFKM(2), PFKP(2), PGM2(7), PMM1(4), PMM2(3), RDH11(3), RDH12(2), RDH13(3), RDH14(1), SORD(2), TPI1(1), TSTA3(4) 15743248 172 100 167 122 109 15 14 18 16 0 0.826 1.000 1.000 279 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3) 5638748 148 100 128 47 106 10 11 11 10 0 7.06e-05 1.000 1.000 280 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL1RN(8), IL6(2), IRAK1(5), IRAK2(15), IRAK3(11), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(3), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 12575253 139 100 134 78 88 12 4 15 20 0 0.581 1.000 1.000 281 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(15), ABCC2(12), ABCG2(5), BCHE(7), CES1(21), CES2(4), CYP3A4(21), CYP3A5(14), UGT1A1(11), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(10), UGT1A7(12), UGT1A8(8), UGT1A9(16) 9767425 208 100 188 90 141 17 11 17 20 2 0.00128 1.000 1.000 282 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(10), F2(13), F2R(8), F3(2), F5(39), F7(7), FGA(42), FGB(10), FGG(10), PROC(11), PROS1(17), SERPINC1(7), TFPI(8) 6998214 184 99 170 72 124 19 8 19 13 1 0.0485 1.000 1.000 283 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(12), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EARS2(2), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GFPT2(9), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSR(2), GSS(9), NADSYN1(4), NAGK(1), QARS(6) 16849083 198 99 191 112 114 24 11 28 20 1 0.611 1.000 1.000 284 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(3), CREBBP(24), EP300(19), FYN(8), IL2RG(3), IL7(5), IL7R(37), JAK1(7), JAK3(11), LCK(17), NMI(4), PIK3CA(10), PIK3R1(4), PTK2B(12), STAT5A(3), STAT5B(5) 11900062 172 99 167 86 103 20 8 23 16 2 0.470 1.000 1.000 285 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(13), COASY(6), DPYD(73), DPYS(28), ENPP1(13), ENPP3(15), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(14) 5933233 183 99 161 51 131 11 3 21 17 0 3.53e-05 1.000 1.000 286 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(7), BAK1(2), BAX(5), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(5), FASLG(15), GZMB(4), JUN(1), MAP2K4(4), MAP3K1(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), PARP1(8), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(10), TRAF1(6), TRAF2(2) 15536074 168 98 166 80 98 18 11 19 22 0 0.306 1.000 1.000 287 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(26), F2(13), F2R(8), FGA(42), FGB(10), FGG(10), PLAT(5), PLAU(3), PLG(36), SERPINB2(20), SERPINE1(6) 5693092 180 98 171 69 126 12 10 18 13 1 0.0350 1.000 1.000 288 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(16), ATR(22), BRCA1(16), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(4), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(19), MDM2(4), MYT1(21), PRKDC(22), RPS6KA1(11), WEE1(2), YWHAQ(3) 17533576 164 98 161 76 100 14 8 29 13 0 0.638 1.000 1.000 289 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME3(8), PGK1(3), PGK2(36), PKLR(14), TKT(6), TKTL1(3), TKTL2(28), TPI1(1) 8638255 170 98 157 95 124 17 5 13 10 1 0.0732 1.000 1.000 290 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PIK3CB(10), PITX2(6), PLD1(15), PLD2(8), PLD3(1), VN1R1(1) 19078956 184 98 176 124 104 16 13 28 23 0 0.868 1.000 1.000 291 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(9), CHAT(20), COMT(4), DBH(16), DDC(16), GAD1(14), GAD2(9), HDC(25), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(11), TPH1(12) 6036350 159 95 150 98 113 14 6 6 19 1 0.221 1.000 1.000 292 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(8), AZIN1(1), BTG1(5), CBX3(2), CLOCK(4), CRY1(7), CRY2(7), EIF4G2(6), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(15), NCKAP1(5), NCOA4(4), NR1D2(11), PER1(8), PER2(12), PIGF(3), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(2), SF3A3(7), SUMO3(2), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(10) 15560924 181 95 178 81 93 18 16 33 21 0 0.530 1.000 1.000 293 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), GHR(43), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(3), MKNK1(7), PABPC1(5), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PRKCA(9), RPS6KB1(4) 11724819 164 95 154 61 98 22 8 16 19 1 0.0467 1.000 1.000 294 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(3), ARSD(3), ARSE(5), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(5), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(10), SMPD1(3), SMPD2(2), SPTLC1(2), SPTLC2(8), UGCG(1) 10226157 182 95 177 111 122 15 3 22 20 0 0.773 1.000 1.000 295 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), BTRC(4), CDC20(1), CDC23(4), CDC27(14), CUL1(3), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(8), ITCH(9), SKP2(3), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(7), WWP2(9) 16992013 161 95 156 75 102 8 8 19 23 1 0.692 1.000 1.000 296 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(7), BAIAP2(8), CASP1(4), CASP3(3), CASP7(4), CASP8(9), GAPDH(3), INSR(23), ITCH(9), MAGI1(38), MAGI2(24), RERE(25), WWP1(7), WWP2(9) 10275967 173 94 168 76 115 12 7 17 21 1 0.221 1.000 1.000 297 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(34), ADRB2(4), GNAS(33), PLCE1(60), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6249260 158 94 151 80 104 17 10 14 13 0 0.297 1.000 1.000 298 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(10), PDE1A(44), PDE1B(15), PLCB1(61), PLCB2(12), PRL(3), TRH(4), VIP(5) 4695304 160 94 140 66 122 5 2 14 17 0 0.00256 1.000 1.000 299 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(7), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(3), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK5(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(10), PIK3CD(8), PIK3R1(4), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 14273666 154 94 148 104 103 11 7 19 13 1 0.880 1.000 1.000 300 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), EGF(22), EGFR(26), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 15637529 168 93 165 91 92 18 8 29 20 1 0.898 1.000 1.000 301 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(12), ACO1(8), ACO2(5), CLYBL(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), OGDHL(44), PC(14), PCK1(28), PCK2(6), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3) 12416508 175 93 167 88 115 7 7 25 21 0 0.142 1.000 1.000 302 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(4), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CFLAR(5), DAXX(10), DFFA(2), DFFB(2), FAF1(9), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), PTPN13(17), RB1(10), RIPK2(3), SPTAN1(10) 17418966 157 92 156 84 71 15 13 32 24 2 0.910 1.000 1.000 303 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGB1(7), ITGB2(17), SELE(33), SELL(12) 5121911 148 92 142 57 105 6 5 12 18 2 0.0296 1.000 1.000 304 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(34), CAP1(2), CDC25C(5), GNAI1(2), GNAS(33), GNB1(1), HRAS(6), MAPK1(4), MAPK3(3), MYT1(21), PIN1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(11), SRC(2) 8761289 156 92 150 95 105 16 8 13 14 0 0.614 1.000 1.000 305 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(13), ARHGEF1(2), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(48), PLCB1(61), PPP1R12B(10), PRKCA(9), ROCK1(6) 8853425 169 92 151 73 123 2 7 19 18 0 0.0829 1.000 1.000 306 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(6), GRB2(2), HRAS(6), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(3), PAK1(4), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(12), SHC1(2), SOS1(10), SRC(2), SYT1(23) 11620131 144 92 136 87 83 15 8 21 17 0 0.917 1.000 1.000 307 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(4), AKT2(8), AKT3(3), BAD(4), BCL2(3), GRB2(2), GSK3A(1), GSK3B(3), IL4R(18), IRS1(5), IRS2(3), JAK1(7), JAK3(11), MAP4K1(12), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(4), PPP1R13B(9), RAF1(12), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(9) 15586079 171 92 169 87 95 25 7 26 17 1 0.532 1.000 1.000 308 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(34), ADRB2(4), CFTR(62), GNAS(33), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2) 5542558 162 91 150 90 108 14 7 14 18 1 0.448 1.000 1.000 309 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BCL2(3), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CFLAR(5), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(14), LMNA(5), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(5), TNFRSF25(6), TNFSF10(10), TNFSF12(1), TRAF2(2) 14242218 138 91 136 78 77 18 10 20 13 0 0.722 1.000 1.000 310 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(8), LCT(54), NAGLU(4), SPAM1(28) 8678408 160 91 156 96 115 11 3 15 16 0 0.653 1.000 1.000 311 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(9), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(18), IL5(4), TGFB1(2), TGFB2(4), TGFB3(3) 8508318 175 91 164 95 128 12 2 14 19 0 0.0299 1.000 1.000 312 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(6), CDK5R1(1), DAB1(48), FYN(8), LRP8(3), RELN(90), VLDLR(5) 5963173 161 91 154 89 114 9 3 16 18 1 0.888 1.000 1.000 313 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(22), EPHB1(31), FYN(8), ITGA1(23), ITGB1(7), L1CAM(11), LYN(11), RAP1B(1), SELP(38) 6728695 156 90 144 78 108 8 5 18 16 1 0.300 1.000 1.000 314 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 14537831 153 90 150 72 82 17 7 30 16 1 0.582 1.000 1.000 315 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(12), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GLS(2), GLS2(3), GLUD1(2), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSS(9), NADSYN1(4), QARS(6) 14165629 175 89 168 91 101 19 10 26 18 1 0.465 1.000 1.000 316 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(4), BCL2(3), EGFR(26), IGF1R(15), MYC(5), POLR2A(14), PPP2CA(1), PRKCA(9), RB1(10), TEP1(36), TERF1(2), TERT(10), TNKS(10), XRCC5(2) 11652428 147 89 143 87 85 15 9 17 19 2 0.720 1.000 1.000 317 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 10680233 143 88 126 61 106 9 9 12 7 0 0.132 1.000 1.000 318 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GCNT1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), WBSCR17(46) 6180311 140 88 129 62 98 10 4 13 15 0 0.0629 1.000 1.000 319 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(18), NFATC2(12), NFKB1(6), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7) 11897942 152 88 145 93 97 12 8 17 18 0 0.878 1.000 1.000 320 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(22), BRCA1(16), BRCA2(24), CHEK1(2), CHEK2(2), FANCA(8), FANCC(2), FANCD2(16), FANCE(4), FANCG(7), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(6), RAD9A(6), TREX1(1) 18449843 148 87 145 74 97 7 5 18 21 0 0.862 1.000 1.000 321 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(11), AGT(8), AGTR2(10), EDN1(9), EDNRA(12), EDNRB(7), EGF(22), EGFR(26), FOS(2), HRAS(6), JUN(1), MYC(5), NFKB1(6), PLCG1(9), PRKCA(9), RELA(4) 8756081 147 87 144 77 100 10 8 13 15 1 0.278 1.000 1.000 322 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(10), CSF1R(13), EGF(22), EGFR(26), GRB2(2), MET(23), PDGFRA(32), PRKCA(9), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2) 8308320 148 87 146 91 97 9 5 18 19 0 0.890 1.000 1.000 323 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(12), CSF1R(13), DDX20(11), E2F1(6), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(6), JUN(1), NCOR2(28), RBL1(14), RBL2(6), SIN3A(11), SIN3B(8) 11072204 144 87 143 81 94 7 3 27 13 0 0.591 1.000 1.000 324 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(10), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(5), CSNK1D(3), CSNK2A1(2), CTNNB1(17), DVL1(1), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2) 12450768 133 87 130 73 66 11 12 20 24 0 0.926 1.000 1.000 325 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(20), FOS(2), HRAS(6), JUN(1), MAPK1(4), MAPK3(3), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(61), PRKCA(9), RAF1(12), RELA(4), TNF(1) 6311573 136 86 124 55 94 10 7 12 13 0 0.0139 1.000 1.000 326 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16) 8660488 160 86 157 82 116 16 2 14 11 1 0.173 1.000 1.000 327 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(2), ENPP6(14), PAFAH1B1(6), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(15), PLD2(8), PPAP2A(1), PPAP2B(11), PPAP2C(10) 9935487 168 86 162 86 104 13 5 22 22 2 0.291 1.000 1.000 328 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(1), POLR3K(1), TAF13(1), TAF6(4), TAF7(3), TAF9(3), TBP(4) 14984109 135 86 131 62 79 12 9 22 13 0 0.384 1.000 1.000 329 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(16), GRM1(13), PLCB1(61), PPP1CA(3), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6801342 147 85 138 94 108 4 6 13 15 1 0.624 1.000 1.000 330 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(3), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(4), TKT(6), TKTL1(3), TKTL2(28) 10337668 132 85 124 91 84 12 7 12 17 0 0.645 1.000 1.000 331 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(9), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(8), POLG2(7), POLH(4), POLI(2), POLK(7), POLL(10), POLM(2), POLQ(26), PRIM1(3), PRIM2(6), REV1(3), REV3L(18) 17244921 143 85 142 70 78 11 11 26 17 0 0.730 1.000 1.000 332 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(32), GSTP1(3) 6071115 159 85 147 75 106 17 5 12 18 1 0.00188 1.000 1.000 333 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), PPARA(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(23) 8558172 136 85 129 78 96 9 5 12 14 0 0.372 1.000 1.000 334 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(15), ATM(16), ATR(22), CCNA1(16), CCND1(2), CCNE1(4), CDC25A(8), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(2), DHFR(1), E2F1(6), GSK3B(3), HDAC1(2), RB1(10), SKP2(3), TFDP1(2), TGFB1(2), TGFB2(4), TGFB3(3) 11971847 127 84 126 61 72 8 11 16 18 2 0.552 1.000 1.000 335 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GPX6(19), GSR(2), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(5), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), OPLAH(13), TXNDC12(1) 8975346 165 84 155 91 106 13 7 23 16 0 0.0987 1.000 1.000 336 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(10), CHIT1(12), CMAS(2), CTBS(6), CYB5R1(1), CYB5R3(2), GFPT1(6), GFPT2(9), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), NPL(2), PGM3(1), RENBP(3), UAP1(2) 12220567 122 84 120 81 75 10 6 19 12 0 0.940 1.000 1.000 337 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(24), DUSP1(1), EP300(19), IKBKB(4), IL1B(8), MAP2K3(9), MAP2K6(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(4), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1) 12666350 125 84 124 78 74 18 5 17 11 0 0.953 1.000 1.000 338 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(5), ABAT(12), ADSL(6), ADSS(2), AGXT(12), ASL(9), ASNS(9), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(9), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), PC(14) 10723068 151 83 147 92 102 16 8 12 13 0 0.429 1.000 1.000 339 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(34), GNAS(33), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6526432 144 83 137 66 97 14 8 9 16 0 0.172 1.000 1.000 340 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 27 ATF1(5), BAD(4), CREB3(1), CREB5(9), DUSP4(4), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(7), MKNK2(4), MOS(6), NFKB1(6), RAP1A(1), RPS6KA1(11), RPS6KA2(6), RPS6KA3(2), SHC1(2), SOS1(10), SOS2(13), TRAF3(5) 11567996 121 83 119 85 81 12 4 13 11 0 0.990 1.000 1.000 341 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(4), BAG4(3), CASP2(1), CASP3(3), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MADD(18), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(3), PAK1(4), PAK2(9), PRKDC(22), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2) 16569459 133 83 131 71 64 10 13 22 20 4 0.751 1.000 1.000 342 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(10), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPHN(9), SRC(2), UBQLN1(5) 5015372 137 82 120 77 100 6 5 14 10 2 0.507 1.000 1.000 343 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(5), HLA-A(4), IL18(3), ITGB1(7), KLRC1(4), KLRC2(7), KLRC3(8), KLRC4(3), KLRD1(7), LAT(3), MAPK3(3), PAK1(4), PIK3CA(10), PIK3R1(4), PTK2B(12), PTPN6(5), SYK(15), VAV1(19) 7396024 123 82 117 84 82 7 4 11 17 2 0.979 1.000 1.000 344 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), GCK(16), GMDS(5), GMPPA(2), GMPPB(4), HK1(3), HK2(15), HK3(15), KHK(2), MPI(2), PFKFB1(4), PFKFB3(5), PFKFB4(8), PFKM(2), PFKP(2), PMM1(4), PMM2(3), SORD(2), TPI1(1) 10151370 124 81 119 96 81 13 8 10 12 0 0.829 1.000 1.000 345 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(33), GNB1(1), NFKB1(6), NOS3(20), NPPA(5), NR3C1(7), PIK3CA(10), PIK3R1(4), RELA(4), SYT1(23) 7604428 130 81 121 58 89 13 5 18 4 1 0.282 1.000 1.000 346 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(2), GLI2(44), GLI3(19), GSK3B(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(3) 7088275 117 81 114 79 80 11 5 12 9 0 0.867 1.000 1.000 347 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(37), AGT(8), AGTR1(10), AGTR2(10), BDKRB2(10), KNG1(15), NOS3(20), REN(12) 4227401 122 80 117 73 81 8 6 10 15 2 0.141 1.000 1.000 348 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(27), PGAP1(9), PIGA(2), PIGB(3), PIGC(3), PIGF(3), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(10), PIGS(1), PIGT(2), PIGU(7), PIGV(10), PIGW(1), PIGX(2), PIGZ(4) 10175297 127 80 124 56 72 9 7 27 12 0 0.0784 1.000 1.000 349 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(29), BST1(2), CD38(6), ENPP1(13), ENPP3(15), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(7), NMNAT3(11), NNMT(11), NNT(4), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(7), NT5M(2), NUDT12(5), QPRT(6) 9184446 160 80 152 72 103 11 6 18 22 0 0.130 1.000 1.000 350 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(9), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), HAL(14) 8995302 135 80 130 71 93 10 5 16 11 0 0.473 1.000 1.000 351 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(3), STAT4(26), TYK2(9) 7913073 139 80 134 65 97 8 4 12 18 0 0.226 1.000 1.000 352 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL2(4), IL2RA(7), IL2RB(12), IL2RG(3), JAK1(7), JAK3(11), JUN(1), LCK(17), MAPK3(3), MAPK8(3), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 9499189 130 80 127 70 78 13 6 19 14 0 0.551 1.000 1.000 353 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(4), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(10), PC(14), PDHA1(5), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(6), PDK4(8), PDP2(5), SDHA(4), SDHC(5), SDHD(2), SUCLG1(4), SUCLG2(3) 12129700 129 80 126 64 82 7 8 15 17 0 0.344 1.000 1.000 354 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4B(6), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), MKNK1(7), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4), TSC1(9), TSC2(14) 11458530 121 80 117 51 64 17 7 15 16 2 0.277 1.000 1.000 355 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(13), BCAT2(1), IARS(10), IARS2(18), ILVBL(5), LARS(13), LARS2(5), PDHA1(5), PDHA2(20), PDHB(1), VARS(16), VARS2(7) 8037888 114 79 105 54 76 12 3 11 12 0 0.340 1.000 1.000 356 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG3(2), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(32), ULK1(11), ULK2(7), ULK3(1) 8906155 135 79 129 72 94 8 6 15 12 0 0.423 1.000 1.000 357 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(3), CAT(8), EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49) 5044091 119 79 115 72 90 10 2 7 10 0 0.285 1.000 1.000 358 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(10), PIK3R1(4), PLCB1(61), PLCG1(9), PRKCA(9), VAV1(19) 5486267 116 79 107 59 87 5 2 9 11 2 0.332 1.000 1.000 359 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(8), ACTN2(21), CAPN1(5), CAPNS1(3), CAPNS2(1), ITGA1(23), ITGB1(7), ITGB3(25), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12) 11836369 130 79 128 68 80 12 7 14 16 1 0.0982 1.000 1.000 360 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 141 78 130 70 97 16 5 9 13 1 0.00254 1.000 1.000 361 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(19), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 141 78 130 70 97 16 5 9 13 1 0.00254 1.000 1.000 362 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2C1(7), MANBA(7), NEU1(6), NEU2(19), NEU3(5), NEU4(16) 7028228 141 78 138 70 103 13 1 13 10 1 0.230 1.000 1.000 363 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(18), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SP1(5), SP3(1), SYT1(23) 8931852 129 77 121 56 83 13 7 11 14 1 0.190 1.000 1.000 364 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(6), ALOX15(11), ALOX15B(9), ALOX5(14), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(13), PTGDS(4), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 6367246 144 76 140 82 95 13 4 15 17 0 0.0806 1.000 1.000 365 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(4), BCL2(3), BCR(14), CRKL(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(3), MYC(5), PIK3CA(10), PIK3R1(4), RAF1(12), SOS1(10), STAT1(5), STAT5A(3), STAT5B(5) 11600861 110 76 108 55 55 15 8 16 15 1 0.690 1.000 1.000 366 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTAP(5), MTFMT(2), MTR(12), SRM(1), TAT(21) 8928478 123 76 121 54 76 11 8 12 15 1 0.0657 1.000 1.000 367 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(17), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(3), CAPNS2(1), EP300(19), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(18), NFATC2(12), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SYT1(23) 10461393 131 76 124 59 84 8 9 14 16 0 0.239 1.000 1.000 368 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(4), IL1A(5), IL1R1(12), IRAK1(5), MAP3K1(4), MAP3K7(1), MYD88(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(42), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 10247356 109 76 102 67 75 7 4 12 11 0 0.814 1.000 1.000 369 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(13), CNR2(6), DNMT1(19), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), TBXA2R(5) 4758781 114 76 109 86 78 16 4 8 8 0 0.358 1.000 1.000 370 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(5), CARS(9), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(8), IARS(10), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3) 13730362 132 75 126 62 78 13 6 17 16 2 0.302 1.000 1.000 371 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(19), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(7), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), PGD(9) 7334581 131 75 124 66 79 11 7 20 14 0 0.0658 1.000 1.000 372 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(10), NAT1(2), NAT2(10), XDH(61) 3426350 116 75 107 79 91 5 6 3 11 0 0.182 1.000 1.000 373 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(24), CPT1A(14), LEP(4), LEPR(31), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8) 6219439 121 75 113 58 83 5 3 11 19 0 0.483 1.000 1.000 374 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKM(2), PFKP(2), PGD(9), PGLS(3), PGM1(8), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(9), TALDO1(4), TKT(6) 8709126 105 75 101 73 67 8 6 10 14 0 0.673 1.000 1.000 375 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(37), CD44(5), CSF1(12), FCGR3A(9), IL1B(8), IL6R(3), SELL(12), SPN(5), TGFB1(2), TGFB2(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3) 5536832 128 75 121 63 94 7 6 5 16 0 0.0715 1.000 1.000 376 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(18), APOA1(1), APOA4(9), APOC1(3), APOC2(1), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(4), LDLR(19), LIPC(10), LPL(6), LRP1(47), SCARB1(5), SOAT1(3) 11782522 144 75 141 85 83 20 9 16 14 2 0.418 1.000 1.000 377 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(59), NRG2(9), NRG3(24), PRKCA(9), PSEN1(3) 3808560 105 74 94 39 76 5 3 6 15 0 0.0327 1.000 1.000 378 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPX1(3), PRKCE(7) 3305458 121 74 105 62 87 8 3 13 8 2 0.255 1.000 1.000 379 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(5), GLB1(10), HEXA(5), HEXB(4), LCT(54), SLC33A1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12) 7030462 134 74 132 82 90 12 1 19 12 0 0.600 1.000 1.000 380 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(8), EPX(9), LPO(20), MPO(12), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(49) 4979106 113 74 109 72 88 9 1 7 8 0 0.398 1.000 1.000 381 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(20), AP2A1(2), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(10), EPN1(6), EPS15(4), NME1(1), PICALM(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(22), SYT1(23) 9128501 134 74 128 63 91 9 5 16 13 0 0.260 1.000 1.000 382 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(9), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(5), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(1), HAL(14) 8046098 120 74 116 66 83 7 4 16 10 0 0.597 1.000 1.000 383 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(12), SNCA(2), SNCAIP(67), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L3(1), UBE2L6(2) 2748962 104 74 93 36 79 10 3 5 7 0 0.0131 1.000 1.000 384 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TPO(49), TYR(11) 4120139 111 74 107 68 82 11 1 5 12 0 0.434 1.000 1.000 385 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4542831 126 74 116 54 85 8 4 7 20 2 0.00854 1.000 1.000 386 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4762451 133 74 122 59 89 8 4 8 22 2 0.0105 1.000 1.000 387 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(8), ACTN2(21), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(30), CTNNB1(17), PTK2(7), PXN(2), SRC(2), VCL(9) 8056585 105 73 100 61 63 8 8 12 13 1 0.408 1.000 1.000 388 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(34), FHL5(13), FSHB(9), FSHR(21), GNAS(33), XPO1(3) 4054852 113 73 104 51 77 12 6 8 10 0 0.192 1.000 1.000 389 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), INSR(23), IRS1(5), JUN(1), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SLC2A4(8), SOS1(10), SRF(3) 10585461 114 73 110 58 51 18 6 27 11 1 0.845 1.000 1.000 390 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(2), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAPK3(3), MPL(9), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), RAF1(12), RASA1(5), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), THPO(10) 12415943 128 73 125 65 69 13 8 24 12 2 0.828 1.000 1.000 391 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CD86(25), CTLA4(2), GRB2(2), HLA-DRA(13), HLA-DRB1(5), ICOS(3), IL2(4), ITK(25), LCK(17), PIK3CA(10), PIK3R1(4), PTPN11(10) 5454390 136 72 129 49 90 9 2 18 15 2 0.0616 1.000 1.000 392 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(27), ITGAM(25), ITGB2(17), SELE(33), SELL(12) 4384333 121 72 120 60 87 6 3 6 17 2 0.0738 1.000 1.000 393 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(6), GTF2A1(2), GTF2B(5), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(19), NCOR2(28), POLR2A(14), RARA(5), RXRA(4), TBP(4) 10591405 122 72 119 55 94 4 5 10 9 0 0.194 1.000 1.000 394 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(27), CDH1(6), CREBBP(24), EP300(19), MAP3K7(1), MAPK3(3), SKIL(3), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9) 10648246 101 72 101 53 52 14 7 14 14 0 0.926 1.000 1.000 395 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(6), HSPA1A(1), IFNG(4), IFNGR1(4), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(35), WT1(10) 7165911 107 72 100 42 54 10 4 13 24 2 0.113 1.000 1.000 396 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(15), ATM(16), BRCA1(16), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(3), MDM2(4), MRE11A(5), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(5), RELA(4), TP73(6) 12304033 96 71 95 48 47 12 3 19 15 0 0.904 1.000 1.000 397 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PGK1(3), PKLR(14), TKT(6), TPI1(1) 7718937 105 71 102 60 74 11 4 6 9 1 0.206 1.000 1.000 398 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GCNT2(7), ST3GAL6(4), ST8SIA1(1) 6824352 103 71 98 54 60 14 7 12 9 1 0.251 1.000 1.000 399 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IGF1(11), IGF1R(15), IRS1(5), JUN(1), MAPK3(3), MAPK8(3), PIK3CA(10), PIK3R1(4), PTPN11(10), RAF1(12), RASA1(5), SHC1(2), SOS1(10), SRF(3) 10236951 109 71 103 52 52 20 3 24 9 1 0.738 1.000 1.000 400 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(4), CAT(8), GH1(5), GHR(43), HRAS(6), IGF1(11), IGF1R(15), PIK3CA(10), PIK3R1(4), SHC1(2) 5668311 108 71 99 45 73 12 2 13 7 1 0.129 1.000 1.000 401 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(10), CD2(29), CD3D(7), CD3E(2), CD3G(1), CD4(9), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(9) 6208723 134 71 124 61 90 10 4 10 20 0 0.0639 1.000 1.000 402 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(4), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(6), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MPST(2), SDS(3), SULT1B1(11), SULT1C2(7), SULT1C4(15), SULT4A1(11) 5361463 108 70 104 34 71 5 11 8 13 0 0.00140 1.000 1.000 403 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(7), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), METTL2B(5), METTL6(2), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SCLY(3), SEPHS1(2), SEPHS2(2), WBSCR22(2) 10680917 110 70 108 61 65 13 5 15 12 0 0.427 1.000 1.000 404 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(25), FOS(2), GRB2(2), HRAS(6), IL3(3), IL3RA(8), JAK2(8), MAPK3(3), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 7164756 94 70 92 48 54 7 6 11 16 0 0.511 1.000 1.000 405 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), BAD(4), CHRNB1(4), CHRNG(3), MUSK(38), PIK3CA(10), PIK3R1(4), PTK2(7), PTK2B(12), RAPSN(1), SRC(2), TERT(10) 6942853 99 69 95 84 64 8 1 17 8 1 0.991 1.000 1.000 406 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(22), EGFR(26), MAP3K1(4), MAPK14(5), NCOR2(28), RARA(5), RXRA(4), THRA(2), THRB(18) 6988569 114 69 112 62 79 11 3 9 12 0 0.519 1.000 1.000 407 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(16), AOC2(9), AOC3(9), CES1(21), DDHD1(8), ESCO1(2), ESCO2(4), LIPA(5), NAT6(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2) 10815802 99 69 95 58 74 4 7 6 8 0 0.821 1.000 1.000 408 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(24), DAXX(10), HRAS(6), PAX3(3), PML(16), RARA(5), RB1(10), SIRT1(2), SP100(12), TNF(1), TNFRSF1A(4), TNFRSF1B(4) 7686287 97 69 97 42 42 15 7 14 17 2 0.332 1.000 1.000 409 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(4), CCND1(2), CCNE1(4), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(2), E2F1(6), HRAS(6), MAPK1(4), MAPK3(3), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(4), RAF1(12), RB1(10), RELA(4), TFDP1(2) 8140669 91 69 89 49 41 11 8 13 15 3 0.748 1.000 1.000 410 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(7), CREBBP(24), EP300(19), NCOA3(19), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(5), RXRA(4) 8838285 105 68 105 57 63 8 5 17 12 0 0.846 1.000 1.000 411 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(6), IL6(2), IL6R(3), IL6ST(11), JAK1(7), JAK2(8), JAK3(11), JUN(1), MAPK3(3), PTPN11(10), RAF1(12), SHC1(2), SOS1(10), SRF(3), STAT3(11) 9819721 109 68 107 61 48 16 5 28 12 0 0.940 1.000 1.000 412 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(25), HLA-DRA(13), HLA-DRB1(5), IFNG(4), IFNGR1(4), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(7), IL4(1), IL4R(18) 5388315 136 68 128 50 101 6 0 10 19 0 0.00577 1.000 1.000 413 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(4), APAF1(7), ATM(16), BAD(4), BAX(5), BCL2(3), CASP3(3), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(9), PTK2(7), PXN(2), STAT1(5), TLN1(12) 11283078 85 67 82 52 48 10 5 12 10 0 0.891 1.000 1.000 414 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(39), AKT1(4), ATM(16), BAX(5), CDKN1A(3), CPB2(1), CSNK1A1(5), CSNK1D(3), HIC1(2), HIF1A(4), HSPA1A(1), IGFBP3(3), MAPK8(3), MDM2(4), NFKBIB(1), NQO1(2) 8512093 96 67 86 48 57 7 3 14 14 1 0.714 1.000 1.000 415 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSR(2), GSS(9), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(61) 4206671 99 66 94 52 72 8 4 7 8 0 0.140 1.000 1.000 416 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(7), LPO(20), MPO(12), PRDX6(4), TPO(49) 3577255 101 66 97 66 78 9 1 5 8 0 0.474 1.000 1.000 417 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(4), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(11), IGF1R(15), INPPL1(16), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RPS6(1), RPS6KB1(4) 8036600 85 66 79 46 50 12 6 9 7 1 0.670 1.000 1.000 418 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(38), MAP2(22), PPP1CA(3), PPP2CA(1), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(7) 7722806 94 65 93 51 51 10 7 11 14 1 0.874 1.000 1.000 419 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(8), ACO2(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), PC(14), PCK1(28), SDHA(4), SUCLG1(4), SUCLG2(3) 8473213 91 65 86 54 61 2 6 10 12 0 0.626 1.000 1.000 420 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(27), AXIN1(10), BTRC(4), CTNNB1(17), DLL1(3), DVL1(1), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(3), WNT1(2) 9023786 85 65 84 52 41 10 7 11 16 0 0.942 1.000 1.000 421 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(4), AP2A1(2), AP2M1(3), BAD(4), BTK(15), EEA1(3), GRASP(3), GSK3A(1), GSK3B(3), LYN(11), PDPK1(5), PFKL(3), PFKM(2), PFKP(2), PLCG1(9), PRKCE(7), PRKCZ(3), RAB5A(2), RPS6KB1(4), VAV2(5) 10372921 91 65 89 67 52 10 6 7 16 0 0.867 1.000 1.000 422 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(4), BAD(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(6), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RAF1(12), RALA(1), RALBP1(3), RALGDS(11), RELA(4), RHOA(3) 7552903 82 65 80 50 44 15 3 15 4 1 0.880 1.000 1.000 423 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), BAD(4), CASP9(2), CHUK(2), GH1(5), GHR(43), NFKB1(6), NFKBIA(2), PDPK1(5), PIK3CA(10), PIK3R1(4), PPP2CA(1), RELA(4) 5968669 92 64 85 50 61 9 5 10 6 1 0.729 1.000 1.000 424 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(7), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(10), SYT1(23) 4947143 96 64 90 70 65 8 3 9 11 0 0.853 1.000 1.000 425 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(6), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(15), FLAD1(14), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), TYR(11) 6398037 101 64 97 32 65 7 5 7 17 0 0.0170 1.000 1.000 426 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1) 10017523 93 64 90 47 53 10 6 18 6 0 0.543 1.000 1.000 427 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(19), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(8) 8528020 99 64 96 63 63 11 3 11 11 0 0.692 1.000 1.000 428 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(29), CD38(6), ENPP1(13), ENPP3(15), NADSYN1(4), NMNAT1(1), NMNAT2(7), NNMT(11), NNT(4), NT5E(7), NT5M(2), QPRT(6) 6212326 105 64 98 47 65 9 5 12 14 0 0.214 1.000 1.000 429 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(5), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP4K2(7), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2) 10155954 77 64 77 46 45 10 3 8 10 1 0.710 1.000 1.000 430 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(7), CD3E(2), CD3G(1), CD4(9), FYN(8), HLA-DRA(13), HLA-DRB1(5), LCK(17), PTPRC(36), ZAP70(8) 3783076 106 64 100 41 71 8 3 9 14 1 0.0194 1.000 1.000 431 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(8), ARG1(2), ARG2(2), ASL(9), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), GAMT(5), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(5) 7380470 92 64 89 40 54 9 5 13 11 0 0.137 1.000 1.000 432 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(54), MPI(2), PGM1(8), PYGL(9), PYGM(14), TPI1(1), TREH(4) 5632350 97 63 96 73 70 7 2 11 7 0 0.753 1.000 1.000 433 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(4), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(4), RB1(10), RELA(4), SP1(5) 7916536 76 63 74 45 34 12 4 9 14 3 0.931 1.000 1.000 434 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(3), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL27(3), RPL27A(1), RPL28(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(2), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1) 9608800 81 63 81 54 43 7 7 14 10 0 0.860 1.000 1.000 435 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTR(12) 7512788 94 63 93 38 56 9 7 10 11 1 0.0419 1.000 1.000 436 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), FDXR(12), SHMT1(2) 6838473 94 63 93 51 55 4 7 13 15 0 0.341 1.000 1.000 437 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(6), BIRC3(7), CASP10(10), CASP3(3), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(4), PRF1(14), SCAP(12), SREBF1(5), SREBF2(10) 7765698 97 63 93 48 57 9 7 14 10 0 0.377 1.000 1.000 438 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(5), MAPK14(5), MAPK8(3), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2) 8161439 84 62 78 41 45 6 2 12 19 0 0.560 1.000 1.000 439 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(3), CCR5(10), CXCL12(8), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(3), PLCG1(9), PRKCA(9), PTK2B(12), SYT1(23) 5899387 96 62 89 75 64 7 5 13 7 0 0.946 1.000 1.000 440 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), IDS(9), IDUA(8), LCT(54), NAGLU(4) 6107486 109 62 107 62 81 9 0 10 9 0 0.466 1.000 1.000 441 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(24), ACACB(23), FASN(26), MCAT(2), OLAH(11), OXSM(2) 6754738 88 62 86 53 53 9 3 8 15 0 0.506 1.000 1.000 442 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(8), B3GAT2(3), B3GAT3(4), CHPF(4), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(9), DSE(20), XYLT1(12), XYLT2(5) 5811712 90 62 90 62 57 13 4 8 8 0 0.545 1.000 1.000 443 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(9), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(13), HLA-DRB1(5), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(4), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), LTA(5), PDGFA(1), TGFB1(2), TGFB2(4), TGFB3(3), TNF(1) 5614094 114 62 111 58 75 5 3 11 20 0 0.0211 1.000 1.000 444 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(24), EP300(19), LPL(6), NCOA1(9), NCOA2(13), PPARG(12), RXRA(4) 7931311 87 62 84 36 52 11 4 12 8 0 0.395 1.000 1.000 445 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(6), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10) 6493871 88 62 86 41 40 17 4 17 10 0 0.460 1.000 1.000 446 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 447 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(2), CDKN2C(1), E2F1(6), RB1(10), RBL1(14), TFDP1(2) 6353530 84 61 84 31 46 4 8 12 12 2 0.0789 1.000 1.000 448 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 449 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(5), GPR34(3), GPR39(12), GPR45(8), GPR65(14), GPR68(3), GPR75(6) 4172726 78 61 75 41 54 5 3 8 8 0 0.0139 1.000 1.000 450 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(6), COPS5(3), EDN1(9), EP300(19), EPO(5), HIF1A(4), JUN(1), LDHA(6), NOS3(20), P4HB(3), VHL(4) 7297451 89 61 86 41 57 5 5 10 12 0 0.562 1.000 1.000 451 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(11), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 5173131 81 61 75 31 47 10 4 11 9 0 0.0233 1.000 1.000 452 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(6), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 82 61 81 47 46 3 7 12 14 0 0.504 1.000 1.000 453 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(15), GPLD1(27), KDELR1(1), KDELR3(3) 6983853 81 60 79 46 41 7 3 17 13 0 0.690 1.000 1.000 454 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(4), BAX(5), BCL2(3), CASP8(9), CYCS(1), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(3), NFKB1(6), NSMAF(6), RAF1(12), RELA(4), RIPK1(3), SMPD1(3), TNFRSF1A(4), TRAF2(2) 8370323 80 60 79 45 44 9 5 11 11 0 0.796 1.000 1.000 455 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), GRB2(2), HRAS(6), MAPK1(4), MAPK3(3), MAPK7(4), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), RPS6KA1(11), SHC1(2) 8066485 92 60 89 63 55 14 5 9 8 1 0.923 1.000 1.000 456 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13) 4320806 97 60 97 46 66 7 2 6 15 1 0.0649 1.000 1.000 457 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(4), BAD(4), GRB2(2), HRAS(6), IGF1R(15), IRS1(5), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(4), RAF1(12), SHC1(2), SOS1(10) 7784376 81 60 77 42 43 13 4 13 7 1 0.721 1.000 1.000 458 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(6), BIRC3(7), CASP3(3), CASP8(9), CFLAR(5), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 11547447 84 60 83 57 47 4 9 13 11 0 0.964 1.000 1.000 459 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(35), HSD17B2(13), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(15), HSD3B2(14) 3418004 96 60 90 38 68 6 6 4 12 0 0.0211 1.000 1.000 460 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(4), CASP10(10), CASP2(1), CASP3(3), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(4), LMNA(5), LMNB1(2), LMNB2(4), PRF1(14) 8328136 93 59 92 48 51 11 7 14 10 0 0.641 1.000 1.000 461 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(2), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(6), JAK2(8), JUN(1), MAPK3(3), MAPK8(3), PLCG1(9), PTPN6(5), RAF1(12), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 8767714 82 59 81 47 39 8 7 15 13 0 0.855 1.000 1.000 462 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(4), FUT2(4), FUT9(29), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST8SIA1(1) 4586406 81 59 76 47 49 9 5 13 5 0 0.478 1.000 1.000 463 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADM(5), ACADS(6), ACADVL(1), ACSL1(9), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(2), EHHADH(6), HADHA(6), PECR(2), SCP2(4), SLC25A20(1) 7229827 74 59 70 36 47 4 3 8 12 0 0.563 1.000 1.000 464 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(2), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(6), JUN(1), KLK2(5), MAPK3(3), MAPK8(3), NGFR(8), PIK3CA(10), PIK3R1(4), PLCG1(9), RAF1(12), SHC1(2), SOS1(10) 7791466 83 59 81 44 40 12 3 18 9 1 0.841 1.000 1.000 465 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(12), RBL2(6), SHC1(2), SOS1(10) 8413700 76 59 75 49 39 9 3 19 6 0 0.961 1.000 1.000 466 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(15), E2F1(6), MDM2(4), MYC(5), PIK3CA(10), PIK3R1(4), POLR1A(13), POLR1B(9), POLR1C(1), RB1(10), TBX2(6), TWIST1(1) 7857531 84 58 82 34 48 9 3 11 10 3 0.185 1.000 1.000 467 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26) 7138206 70 58 69 38 39 9 2 13 7 0 0.556 1.000 1.000 468 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6(2), IL6R(3), JAK1(7), JAK2(8), JAK3(11), PIAS3(6), PTPRU(23), REG1A(8), SRC(2), STAT3(11) 6479384 85 58 84 55 48 10 3 10 14 0 0.772 1.000 1.000 469 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(12), CYP11A1(14), CYP11B2(12), CYP17A1(7), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 2941950 90 57 85 58 66 9 1 5 9 0 0.0645 1.000 1.000 470 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(40), CYP2C9(41) 862439 81 57 73 58 61 5 2 2 11 0 0.830 1.000 1.000 471 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(26), HADHA(6), HSD17B12(4), PECR(2), SCD(4) 6109332 78 57 78 37 48 7 4 8 11 0 0.0492 1.000 1.000 472 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(18), NFATC2(12), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5161279 88 56 84 56 57 9 3 5 14 0 0.607 1.000 1.000 473 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(7), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 6426475 77 56 75 41 46 10 1 13 7 0 0.428 1.000 1.000 474 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(2), IL22RA1(13), IL22RA2(3), JAK1(7), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), TYK2(9) 7778061 87 56 87 57 50 7 6 15 9 0 0.848 1.000 1.000 475 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(22), EGFR(26), ERBB3(7), NRG1(23), UBE2D1(1) 4414469 79 55 79 51 54 4 3 8 9 1 0.955 1.000 1.000 476 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(7), FUT1(4), FUT2(4), FUT9(29), GBGT1(4), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 4318655 75 55 70 38 45 9 3 12 6 0 0.233 1.000 1.000 477 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(7), JAK2(8), JAK3(11), PIAS1(7), PIAS3(6), PTPRU(23), REG1A(8), SOAT1(3) 5825301 77 55 76 35 47 9 2 6 13 0 0.167 1.000 1.000 478 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(22), EGFR(26), HGS(5), RAB5A(2), TF(16), TFRC(4) 5473784 78 54 78 50 52 5 5 6 10 0 0.904 1.000 1.000 479 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(7), ATM(16), BAX(5), BCL2(3), CCND1(2), CCNE1(4), CDK2(1), CDKN1A(3), E2F1(6), MDM2(4), PCNA(2), RB1(10), TIMP3(5) 7064843 68 54 67 30 28 7 4 12 15 2 0.640 1.000 1.000 480 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(4), BCAR1(5), CDKN1B(2), GRB2(2), ILK(2), ITGB1(7), MAPK1(4), MAPK3(3), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(4), PTK2(7), SHC1(2), SOS1(10) 7844630 71 54 69 41 36 10 5 15 4 1 0.927 1.000 1.000 481 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(24), EP300(19), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 9521393 82 54 82 39 45 10 6 13 8 0 0.483 1.000 1.000 482 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(33), GNB1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9) 4059172 74 53 70 41 52 8 3 6 5 0 0.726 1.000 1.000 483 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(2), GCK(16), GFPT1(6), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), PGM3(1), RENBP(3), UAP1(2) 7242946 79 53 76 55 51 5 2 12 9 0 0.915 1.000 1.000 484 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(5), CD3D(7), CD3E(2), CD3G(1), GZMB(4), HLA-A(4), ICAM1(2), ITGAL(27), ITGB2(17), PRF1(14) 3717659 83 53 82 38 48 8 3 5 18 1 0.0550 1.000 1.000 485 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(12), ACYP1(1), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(7), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 11127647 77 53 76 47 42 11 6 12 6 0 0.906 1.000 1.000 486 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(7), BCL2(3), CASP3(3), CASP9(2), CYCS(1), DAXX(10), FAS(5), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1) 4856088 69 53 67 37 43 7 3 7 9 0 0.461 1.000 1.000 487 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(1), GRB2(2), HRAS(6), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(4), PLCG1(9), PRKCA(9), SHC1(2), SOS1(10) 6637650 78 53 76 43 44 10 3 11 9 1 0.802 1.000 1.000 488 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), PSMA7(1), WASF1(5), WASF2(6), WASF3(14), WASL(4) 6348133 72 52 71 38 44 7 4 9 8 0 0.818 1.000 1.000 489 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT4(3), CHST1(11), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 5319249 73 52 72 49 47 15 3 4 4 0 0.551 1.000 1.000 490 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(3), CCR3(11), CD4(9), HLA-DRA(13), HLA-DRB1(5), IL1B(8), IL4(1), IL5(4), IL5RA(17), IL6(2) 2279822 73 52 67 38 55 0 1 6 11 0 0.0595 1.000 1.000 491 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CDK2(1), CHEK1(2), MYT1(21), RB1(10), WEE1(2) 6870982 69 52 67 30 39 4 3 10 11 2 0.491 1.000 1.000 492 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(4), WASL(4) 5555636 70 51 69 26 45 4 3 11 6 1 0.219 1.000 1.000 493 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(16), AMT(1), ATIC(5), DHFR(1), FTCD(4), GART(10), MTFMT(2), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 8079674 77 51 75 44 52 6 3 8 8 0 0.615 1.000 1.000 494 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1D(3), CSNK1E(5), NPAS2(6), NR1D1(1), PER1(8), PER2(12), PER3(12) 7252975 73 51 69 51 49 7 1 6 10 0 0.946 1.000 1.000 495 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(9), CHAT(20), CHKA(2), PCYT1A(3), PDHA1(5), PDHA2(20), PEMT(3), SLC18A3(2) 2931222 64 50 60 33 45 7 2 3 6 1 0.164 1.000 1.000 496 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(4), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(2), SIRT1(2), SIRT2(1), SIRT5(6), SIRT7(3), VNN2(17) 5055319 61 50 59 19 38 8 4 7 4 0 0.0392 1.000 1.000 497 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(10), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(12), JUND(1), MYOG(3), NR4A3(10), WDR1(6) 4534195 64 50 59 31 42 5 2 5 10 0 0.462 1.000 1.000 498 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(12), HDAC9(45), MEF2A(3), MEF2B(3), MEF2C(5), MEF2D(6), MYOD1(1) 3182933 80 50 70 39 64 6 2 3 5 0 0.209 1.000 1.000 499 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(24), EP300(19), ESR1(6), MAPK1(4), MAPK3(3), PELP1(14), SRC(2) 6263992 72 50 71 37 44 7 5 11 5 0 0.639 1.000 1.000 500 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(5), MAPK8(3), NFKB1(6), RELA(4), TNFRSF13B(11), TNFRSF17(7), TNFSF13B(3), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 6134800 60 50 59 26 42 6 0 8 4 0 0.239 1.000 1.000 501 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(13), ARHGDIB(4), CASP1(4), CASP10(10), CASP3(3), CASP8(9), CASP9(2), CYCS(1), GZMB(4), JUN(1), PRF1(14) 5517335 72 49 70 35 46 5 3 13 5 0 0.608 1.000 1.000 502 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(5), AFMID(2), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5716791 66 49 62 39 36 5 4 7 14 0 0.633 1.000 1.000 503 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(18), IRS1(5), JAK1(7), JAK3(11), RPS6KB1(4), SHC1(2), STAT6(9) 6294755 66 49 65 32 37 10 4 8 7 0 0.278 1.000 1.000 504 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(16), AMT(1), ATIC(5), ATP6V0C(3), DHFR(1), GART(10), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 7629387 74 49 72 37 49 6 4 8 7 0 0.337 1.000 1.000 505 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(5), ENO3(4), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3) 3561109 67 49 64 34 44 6 2 7 8 0 0.132 1.000 1.000 506 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(6), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), NGFR(8), RAF1(12) 3140623 55 48 53 29 26 8 3 9 9 0 0.353 1.000 1.000 507 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(10), DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(15), PON2(3), PON3(6), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 3856527 72 48 71 35 52 4 2 7 7 0 0.116 1.000 1.000 508 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(5), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5) 9515594 57 48 57 49 36 6 1 6 8 0 0.994 1.000 1.000 509 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(3), OPRK1(23), POLR2A(14), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5485395 70 47 69 67 51 3 4 5 7 0 0.997 1.000 1.000 510 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5458276 64 47 60 35 35 5 3 7 14 0 0.514 1.000 1.000 511 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(29), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), KITLG(10) 2619952 74 47 66 33 53 3 2 8 8 0 0.0671 1.000 1.000 512 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(7), BAK1(2), BAX(5), BCL2(3), BIK(2), BIRC2(6), BIRC3(7), CASP3(3), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(3) 5753598 58 47 57 21 29 6 7 6 10 0 0.228 1.000 1.000 513 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(6), JAK1(7), PTPRU(23), REG1A(8), STAT1(5), STAT2(6), TYK2(9) 5351023 67 47 66 37 38 8 1 8 12 0 0.347 1.000 1.000 514 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2) 5870983 58 46 56 27 38 4 2 8 6 0 0.563 1.000 1.000 515 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(14), CDO1(6), CSAD(7), GAD1(14), GAD2(9), GGT1(8) 2421221 58 46 55 36 36 8 4 5 5 0 0.626 1.000 1.000 516 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(7), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 5990805 66 46 64 34 38 8 3 11 6 0 0.467 1.000 1.000 517 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(11), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4) 5348314 53 45 52 27 24 6 6 5 12 0 0.652 1.000 1.000 518 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(7), CHST12(7), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(3), SULT1E1(16), SULT2A1(9), SULT2B1(6), SUOX(4) 3896847 78 45 75 43 57 6 0 6 9 0 0.321 1.000 1.000 519 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(2), BNIP1(4), GOSR1(2), GOSR2(3), SNAP25(9), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(2), STX3(2), STX4(1), STX5(4), STX6(2), TSNARE1(5), USE1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP7(8), VAMP8(1), VTI1A(1), VTI1B(1) 7070200 63 45 61 32 38 4 2 9 10 0 0.305 1.000 1.000 520 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(1), IL10(2), IL10RA(9), IL10RB(7), IL1A(5), IL6(2), JAK1(7), STAT1(5), STAT3(11), STAT5A(3), TNF(1) 5208279 56 45 55 36 30 4 5 8 9 0 0.663 1.000 1.000 521 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(3), ME1(22), PC(14), PDHA1(5), SLC25A11(4) 3974326 62 45 60 30 39 6 2 10 4 1 0.180 1.000 1.000 522 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(6), IFNAR1(3), IFNAR2(11), IFNB1(6), MAPK8(3), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4) 4723058 55 45 54 29 37 3 1 8 6 0 0.655 1.000 1.000 523 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(4), HMGB2(2), NME1(1), PRF1(14), SET(3) 4524146 68 45 66 27 37 6 6 11 8 0 0.224 1.000 1.000 524 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL15(4), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL9(1), LTA(5), TNF(1) 4210761 67 44 65 42 45 3 2 4 13 0 0.369 1.000 1.000 525 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(25), CKM(3), GPT(4), LDHA(6), LDHB(2), LDHC(7), MAPK14(5), NCL(6) 3838812 58 44 55 29 39 7 6 3 3 0 0.332 1.000 1.000 526 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(4), IFNGR1(4), JAK1(7), JAK2(8), PLA2G2A(2), PTPRU(23), REG1A(8), STAT1(5) 4868210 65 44 64 28 37 6 1 6 15 0 0.173 1.000 1.000 527 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), IMPA2(5), ISYNA1(1), PGM1(8), PGM3(1), TGDS(1) 4973149 66 43 64 45 46 5 2 7 6 0 0.664 1.000 1.000 528 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(19), MBTPS1(9), MBTPS2(3), SCAP(12), SREBF1(5), SREBF2(10) 5067953 60 43 57 30 40 3 3 10 4 0 0.299 1.000 1.000 529 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(9), CYP2E1(14), NR1I3(7), PTGS1(20), PTGS2(13) 2299063 63 42 61 37 47 5 0 2 9 0 0.255 1.000 1.000 530 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(4), BAK1(2), BAX(5), BCL10(3), BCL2(3), BCL2L11(8), CASP9(2), CES1(21) 4579626 55 42 52 23 39 6 3 3 4 0 0.331 1.000 1.000 531 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(12), CAPN1(5), CAPNS1(3), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(5), CSNK1D(3), GSK3B(3), MAPT(10), PPP2CA(1) 3844516 50 41 48 24 30 4 2 7 7 0 0.335 1.000 1.000 532 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), PAPSS1(4), PAPSS2(5), SCLY(3), SEPHS1(2) 5313609 55 41 55 31 33 5 4 6 7 0 0.428 1.000 1.000 533 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9) 4464580 54 41 54 27 37 2 2 7 6 0 0.489 1.000 1.000 534 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(9) 4464580 54 41 54 27 37 2 2 7 6 0 0.489 1.000 1.000 535 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(6), FOS(2), FYN(8), JUN(1), MAPK14(5), THBS1(31) 3160320 56 41 55 34 36 2 4 5 9 0 0.814 1.000 1.000 536 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 537 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 538 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(2), DHCR7(10), FDFT1(1), FDPS(3), GGCX(2), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SQLE(4), TM7SF2(5) 8219769 53 40 53 41 28 11 2 9 3 0 0.960 1.000 1.000 539 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(9), POLR2A(14), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(4), POLR2H(3), POLR2J(2), POLR2L(1), POLRMT(4) 5721949 54 40 52 25 30 6 2 12 4 0 0.381 1.000 1.000 540 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), PGM1(8), PGM3(1), TGDS(1) 4367056 60 40 58 40 42 5 2 6 5 0 0.659 1.000 1.000 541 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(7), IL4(1), TGFB1(2), TGFB2(4), TGFB3(3), TGFBR2(9), TGFBR3(9), TOB1(3), TOB2(3) 4494803 61 40 61 31 46 3 1 1 10 0 0.259 1.000 1.000 542 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4) 7697587 41 39 41 33 25 6 1 4 5 0 0.979 1.000 1.000 543 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(4), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1) 6878598 48 39 47 24 26 6 2 10 4 0 0.630 1.000 1.000 544 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(9), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL9(1) 2580061 57 39 55 37 38 2 1 6 10 0 0.374 1.000 1.000 545 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(27), GNA12(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5) 4312019 53 38 53 33 33 4 1 9 6 0 0.846 1.000 1.000 546 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(16), GOT1(6), GOT2(6), TAT(21), TYR(11) 2008554 60 38 58 31 44 5 3 2 6 0 0.302 1.000 1.000 547 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(16), CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2) 3635220 49 38 49 20 28 2 4 7 6 2 0.248 1.000 1.000 548 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(9), CPS1(29), GLS(2), GLUD1(2), GOT1(6) 3274065 50 38 47 21 33 4 2 9 2 0 0.292 1.000 1.000 549 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), DHFR(1), FPGS(3), GGH(4), SPR(4) 2730835 53 37 49 27 37 5 4 1 6 0 0.0732 1.000 1.000 550 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(22), CDC25C(5), CHEK1(2), CHEK2(2) 6462961 47 37 46 26 33 3 2 5 4 0 0.890 1.000 1.000 551 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(7), JAK2(8), JAK3(11), MAPK1(4), MAPK3(3), STAT3(11), TYK2(9) 4971829 53 37 53 42 28 6 4 8 7 0 0.966 1.000 1.000 552 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNAR2(11), IFNB1(6), JAK1(7), STAT1(5), STAT2(6), TYK2(9) 4609311 48 36 48 24 30 3 2 8 5 0 0.410 1.000 1.000 553 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(9), AOC3(9), CES1(21), ESD(3) 2570858 42 35 39 25 32 2 1 3 4 0 0.548 1.000 1.000 554 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(15), LTB4R(1), P2RY1(5), P2RY2(10), P2RY6(2) 2546495 42 35 41 34 27 6 2 4 2 1 0.291 1.000 1.000 555 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(13), EIF2AK4(16), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF5(2), GSK3B(3), PPP1CA(3) 4952542 43 34 42 20 23 4 1 9 6 0 0.633 1.000 1.000 556 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), FBXW7(11), RB1(10), TFDP1(2) 3483175 41 33 40 17 18 2 5 5 9 2 0.395 1.000 1.000 557 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(3), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(5), PPT2(1) 3623871 38 33 38 16 23 4 4 3 4 0 0.312 1.000 1.000 558 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(15), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(4), FUT2(4), FUT3(8), ST3GAL3(3), ST3GAL4(1) 3064649 39 33 37 25 25 6 2 2 4 0 0.574 1.000 1.000 559 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(4), RPN2(4), UBE2A(1), UBE3A(6) 5529517 41 33 41 22 24 5 2 7 3 0 0.664 1.000 1.000 560 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(2), ALAS2(6), CPO(5), FECH(3), GATA1(4), HBA1(1), HBB(8), HMBS(1), UROS(1) 3298723 36 32 35 20 27 2 0 2 5 0 0.382 1.000 1.000 561 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(3), PGK1(3), PKLR(14), TPI1(1) 3925043 45 32 42 28 29 4 1 5 6 0 0.322 1.000 1.000 562 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(6), GREB1(23), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(5) 4570886 50 32 49 28 35 4 4 3 4 0 0.312 1.000 1.000 563 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 BFAR(2), CAMP(2), CREB3(1), CREB5(9), MAPK1(4), RAF1(12), SNX13(5), SRC(2), TERF2IP(2) 4123067 39 32 37 29 28 3 1 4 3 0 0.935 1.000 1.000 564 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(8), CLOCK(4), CRY1(7), CRY2(7), CSNK1E(5), PER1(8) 3605154 39 31 38 23 26 5 1 3 4 0 0.801 1.000 1.000 565 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(9), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 7104319 40 31 40 27 24 3 4 6 3 0 0.950 1.000 1.000 566 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), ADSS(2), DHFR(1), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(8), PRPS2(3), RRM1(3), SRM(1) 5315371 38 31 38 36 22 2 2 5 7 0 0.995 1.000 1.000 567 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(9), CD80(4), HLA-DRA(13), HLA-DRB1(5), IL10(2), IL2(4), IL4(1) 1685448 40 30 38 22 28 0 0 6 5 1 0.230 1.000 1.000 568 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), HMGCS1(2), IDI1(1), LSS(4), MVD(1), MVK(2), NSDHL(3), PMVK(2), SQLE(4) 5613075 38 30 38 28 19 8 1 8 2 0 0.958 1.000 1.000 569 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(4), DFFA(2), DFFB(2), GZMB(4), HMGB1(1), HMGB2(2), TOP2A(11), TOP2B(9) 3787166 38 30 37 12 25 2 5 2 4 0 0.216 1.000 1.000 570 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(9), PTPRA(9), SRC(2) 3961867 40 30 39 27 28 4 1 3 4 0 0.785 1.000 1.000 571 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(6), PTK2B(12), SHC1(2), SOS1(10), SRC(2) 3758030 34 29 34 31 22 3 0 6 3 0 0.997 1.000 1.000 572 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(12), ACO1(8), ACO2(5), ACSS1(2), ACSS2(5), FH(3), IDH2(2), MDH1(3), MDH2(4) 5343862 44 29 42 32 26 0 2 7 9 0 0.893 1.000 1.000 573 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(10), PLCG1(9), PRKCA(9), PTK2B(12) 2884962 40 29 38 35 31 3 1 2 3 0 0.825 1.000 1.000 574 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(3), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 3358600 35 29 35 21 20 7 2 3 3 0 0.649 1.000 1.000 575 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(3), CSF1(12), IL1B(8), MST1(2), MST1R(10), TNF(1) 2797568 36 29 35 33 25 5 1 2 3 0 0.968 1.000 1.000 576 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDK2(1), CDKN1B(2), CUL1(3), E2F1(6), RB1(10), SKP2(3), TFDP1(2), UBE2M(1) 3665141 32 29 32 17 13 2 5 4 6 2 0.675 1.000 1.000 577 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 3515682 33 29 33 16 22 1 2 3 5 0 0.416 1.000 1.000 578 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 CDC34(4), NRF1(7), TAX1BP3(1), UBE2A(1), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(3), UBE2J1(2), UBE2L3(1), UBE2L6(2), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(6) 4280909 39 29 39 20 25 4 2 4 4 0 0.673 1.000 1.000 579 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), IDI1(1), LSS(4), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SQLE(4) 4698459 35 28 35 29 17 6 1 8 3 0 0.978 1.000 1.000 580 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), SDS(3) 3568463 32 27 31 20 21 4 1 2 4 0 0.797 1.000 1.000 581 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(4), OXCT2(5) 3051553 39 27 37 22 24 5 1 4 5 0 0.714 1.000 1.000 582 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(3), NFE2L2(4), PRKCA(9) 3783534 32 26 30 18 22 1 0 3 6 0 0.666 1.000 1.000 583 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(25), RANGAP1(3) 3635217 29 26 28 13 20 2 1 1 5 0 0.681 1.000 1.000 584 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(10), EPHX2(6), HSD3B7(5), RDH11(3), RDH12(2), RDH13(3), RDH14(1) 2057178 30 25 30 19 19 2 3 3 3 0 0.555 1.000 1.000 585 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NFS1(4), TPK1(11) 2729917 27 25 27 14 17 1 2 2 5 0 0.766 1.000 1.000 586 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(29), PDXK(2), PNPO(1), PSAT1(4) 2078451 36 25 34 23 28 1 2 4 1 0 0.761 1.000 1.000 587 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB10(2), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4) 3756764 32 25 32 13 17 4 2 7 2 0 0.446 1.000 1.000 588 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(7), APOBEC1(3), APOBEC2(5), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(3) 3153147 28 24 27 38 20 2 3 2 1 0 1.000 1.000 1.000 589 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3) 3720288 29 24 29 13 17 3 3 4 2 0 0.532 1.000 1.000 590 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST3GAL5(3), ST6GALNAC2(3), ST6GALNAC4(4), ST8SIA1(1) 2421539 23 23 23 13 14 3 2 3 1 0 0.470 1.000 1.000 591 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(4), IFNGR2(4), JAK1(7), JAK2(8), STAT1(5) 3480656 32 23 30 13 15 1 1 5 10 0 0.626 1.000 1.000 592 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), IDH2(2), MDH1(3), OGDH(10), SDHA(4) 4043724 29 23 29 24 18 0 2 6 3 0 0.953 1.000 1.000 593 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(7), HADHA(6), SDS(3) 3331751 27 22 26 13 17 4 0 3 3 0 0.430 1.000 1.000 594 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(2), ALAS2(6), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1) 3228730 25 22 25 13 17 2 1 2 3 0 0.489 1.000 1.000 595 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(3), FURIN(7), NOTCH1(9), PSEN1(3) 3928050 23 22 23 21 12 4 2 4 1 0 0.941 1.000 1.000 596 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(3), ACTR3(3), ARPC1A(1), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), WASF1(5), WASL(4) 3291311 29 22 29 12 17 4 2 4 2 0 0.420 1.000 1.000 597 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9) 1367799 31 22 30 23 22 2 0 3 4 0 0.631 1.000 1.000 598 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(8), ACO2(5), FH(3), IDH2(2), MDH1(3), MDH2(4) 3464572 25 21 23 17 14 0 2 3 6 0 0.829 1.000 1.000 599 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1) 2985660 22 21 22 13 13 1 1 6 1 0 0.865 1.000 1.000 600 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(8), BMPR1A(2), BMPR1B(4), BMPR2(7) 2683733 21 20 21 11 10 4 2 3 2 0 0.642 1.000 1.000 601 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(4), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 2066224 22 19 20 11 14 3 0 3 2 0 0.443 1.000 1.000 602 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(6), GBA(7), GGT1(8), SHMT1(2), SHMT2(3) 2292319 26 18 25 15 19 3 0 3 1 0 0.432 1.000 1.000 603 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(3), EIF2S1(1), NFKB1(6), NFKBIA(2), RELA(4) 3782875 18 18 18 9 10 3 1 2 2 0 0.595 1.000 1.000 604 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(1), HGD(15) 956700 20 17 20 19 13 3 2 0 2 0 0.932 1.000 1.000 605 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(2), CBS(7), CTH(1), MUT(5) 2158481 16 16 16 10 11 2 1 1 1 0 0.703 1.000 1.000 606 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(3), KARS(4) 1992973 15 15 15 7 13 0 0 2 0 0 0.629 1.000 1.000 607 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(2), RAB5A(2) 1797950 17 15 16 12 13 2 0 1 1 0 0.792 1.000 1.000 608 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2) 2324817 18 14 18 17 5 5 3 3 2 0 0.987 1.000 1.000 609 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(3), GGT1(8), SHMT1(2), SHMT2(3) 1737524 16 13 16 13 11 2 1 2 0 0 0.765 1.000 1.000 610 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(20) 780976 21 13 20 15 15 2 1 2 1 0 0.772 1.000 1.000 611 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4) 1253962 22 13 21 10 14 2 0 1 5 0 0.317 1.000 1.000 612 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(6) 2099109 11 11 11 11 5 0 1 0 5 0 0.979 1.000 1.000 613 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(7) 1320714 11 11 11 11 7 0 1 2 1 0 0.936 1.000 1.000 614 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4) 1813037 11 11 11 7 6 1 1 3 0 0 0.769 1.000 1.000 615 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(6) 1645771 10 10 10 10 4 0 1 0 5 0 0.973 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 909034 5 5 5 5 5 0 0 0 0 0 0.858 1.000 1.000