E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.089 0.195 -9999.0 0.0 -0.387 107.0 107.0 KLHL20 -0.012 0.096 0.21 7.0 -0.218 23.0 30.0 CYFIP2 0.015 0.09 -9999.0 0.0 -0.417 15.0 15.0 Rac1/GDP -0.032 0.126 0.255 1.0 -0.246 75.0 76.0 ENAH -0.085 0.19 -9999.0 0.0 -0.386 99.0 99.0 AP1M1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.011 0.092 -9999.0 0.0 -0.176 66.0 66.0 ABI1/Sra1/Nap1 -0.036 0.051 -9999.0 0.0 -0.149 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.032 0.162 -9999.0 0.0 -0.25 123.0 123.0 RAPGEF1 -0.066 0.172 0.239 3.0 -0.354 88.0 91.0 CTNND1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.085 0.205 -9999.0 0.0 -0.402 106.0 106.0 CRK -0.076 0.184 -9999.0 0.0 -0.374 94.0 94.0 E-cadherin/gamma catenin/alpha catenin -0.017 0.136 -9999.0 0.0 -0.249 91.0 91.0 alphaE/beta7 Integrin 0.004 0.116 -9999.0 0.0 -0.292 48.0 48.0 IQGAP1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.03 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.088 0.197 -9999.0 0.0 -0.401 100.0 100.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.024 0.058 -9999.0 0.0 -0.134 67.0 67.0 MLLT4 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.069 -9999.0 0.0 -0.224 21.0 21.0 PI3K -0.026 0.076 -9999.0 0.0 -0.169 67.0 67.0 ARF6 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.039 0.149 -9999.0 0.0 -0.295 92.0 92.0 TIAM1 0.008 0.105 -9999.0 0.0 -0.417 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.001 0.126 -9999.0 0.0 -0.212 91.0 91.0 AKT1 -0.007 0.056 0.156 4.0 -9999.0 0.0 4.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.08 0.195 -9999.0 0.0 -0.417 92.0 92.0 RhoA/GDP -0.026 0.135 0.282 4.0 -0.247 78.0 82.0 actin cytoskeleton organization -0.006 0.075 0.172 9.0 -0.159 23.0 32.0 CDC42/GDP -0.028 0.135 0.282 4.0 -0.246 79.0 83.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.036 0.105 -9999.0 0.0 -0.213 93.0 93.0 ITGB7 -0.026 0.154 -9999.0 0.0 -0.417 49.0 49.0 RAC1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.135 -9999.0 0.0 -0.227 91.0 91.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.012 0.116 -9999.0 0.0 -0.211 91.0 91.0 mol:GDP -0.048 0.143 0.284 4.0 -0.281 79.0 83.0 CDC42/GTP/IQGAP1 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.02 0.14 0.272 3.0 -0.253 76.0 79.0 RAC1/GTP/IQGAP1 0.041 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.052 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.002 0.056 0.142 12.0 -0.106 20.0 32.0 NME1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.089 0.197 -9999.0 0.0 -0.403 99.0 99.0 regulation of cell-cell adhesion -0.018 0.075 -9999.0 0.0 -0.156 68.0 68.0 WASF2 -0.004 0.043 0.106 4.0 -0.097 6.0 10.0 Rap1/GTP -0.012 0.101 -9999.0 0.0 -0.193 67.0 67.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.021 0.16 -9999.0 0.0 -0.234 124.0 124.0 CCND1 0.001 0.066 0.161 12.0 -0.129 20.0 32.0 VAV2 -0.092 0.244 0.365 1.0 -0.661 27.0 28.0 RAP1/GDP -0.011 0.117 0.298 3.0 -0.207 76.0 79.0 adherens junction assembly -0.086 0.192 -9999.0 0.0 -0.391 99.0 99.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.029 0.147 -9999.0 0.0 -0.228 121.0 121.0 E-cadherin/beta catenin -0.069 0.144 -9999.0 0.0 -0.311 95.0 95.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.085 0.192 -9999.0 0.0 -0.388 100.0 100.0 PIK3CA 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.057 0.123 -9999.0 0.0 -0.349 27.0 27.0 E-cadherin/beta catenin/alpha catenin -0.016 0.136 -9999.0 0.0 -0.249 91.0 91.0 ITGAE 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.088 0.209 -9999.0 0.0 -0.41 106.0 106.0