Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.087 0.166 0.304 134.0 -9999.0 0.0 134.0 KIRREL 0.001 0.051 -9999.0 0.0 -0.425 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.087 0.166 -9999.0 0.0 -0.304 134.0 134.0 PLCG1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.039 0.137 -9999.0 0.0 -0.226 122.0 122.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.06 0.119 -9999.0 0.0 -0.229 119.0 119.0 FYN -0.055 0.133 0.242 20.0 -0.215 133.0 153.0 mol:Ca2+ -0.041 0.134 -9999.0 0.0 -0.224 123.0 123.0 mol:DAG -0.04 0.136 -9999.0 0.0 -0.225 123.0 123.0 NPHS2 -0.01 0.038 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.04 0.136 -9999.0 0.0 -0.225 123.0 123.0 regulation of endocytosis -0.044 0.122 -9999.0 0.0 -0.202 132.0 132.0 Nephrin/NEPH1/podocin/Cholesterol -0.054 0.131 -9999.0 0.0 -0.224 133.0 133.0 establishment of cell polarity -0.087 0.166 -9999.0 0.0 -0.304 134.0 134.0 Nephrin/NEPH1/podocin/NCK1-2 -0.028 0.138 -9999.0 0.0 -0.207 131.0 131.0 Nephrin/NEPH1/beta Arrestin2 -0.044 0.124 -9999.0 0.0 -0.204 132.0 132.0 NPHS1 -0.147 0.219 -9999.0 0.0 -0.415 145.0 145.0 Nephrin/NEPH1/podocin -0.052 0.125 -9999.0 0.0 -0.216 133.0 133.0 TJP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.04 0.137 -9999.0 0.0 -0.226 123.0 123.0 CD2AP 0.031 0.026 -9999.0 0.0 -0.417 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.042 0.14 -9999.0 0.0 -0.226 130.0 130.0 GRB2 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.055 0.126 0.246 24.0 -0.204 127.0 151.0 cytoskeleton organization -0.081 0.143 0.203 5.0 -0.285 117.0 122.0 Nephrin/NEPH1 -0.055 0.117 -9999.0 0.0 -0.207 134.0 134.0 Nephrin/NEPH1/ZO-1 -0.054 0.142 -9999.0 0.0 -0.239 133.0 133.0