Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.062 -9999.0 0.0 -0.371 6.0 6.0 IHH 0.043 0.033 -9999.0 0.0 -0.159 4.0 4.0 SHH Np/Cholesterol/GAS1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.057 0.083 -9999.0 0.0 -0.336 6.0 6.0 SMO 0.027 0.07 -9999.0 0.0 -0.313 9.0 9.0 AKT1 0.032 0.08 -9999.0 0.0 -0.334 11.0 11.0 ARRB2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.027 0.069 -9999.0 0.0 -0.309 9.0 9.0 STIL 0.045 0.077 0.212 48.0 -0.247 4.0 52.0 DHH N/PTCH2 0.035 0.064 -9999.0 0.0 -0.296 12.0 12.0 DHH N/PTCH1 0.039 0.074 -9999.0 0.0 -0.258 17.0 17.0 PIK3CA 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.077 -9999.0 0.0 -0.417 11.0 11.0 PTHLH 0.026 0.099 -9999.0 0.0 -0.632 7.0 7.0 determination of left/right symmetry 0.027 0.069 -9999.0 0.0 -0.309 9.0 9.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.026 0.099 -9999.0 0.0 -0.626 7.0 7.0 IHH N/Hhip 0.04 0.024 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.025 0.059 -9999.0 0.0 -0.301 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.027 0.069 -9999.0 0.0 -0.309 9.0 9.0 pancreas development 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.03 0.026 -9999.0 0.0 -0.417 1.0 1.0 PI3K 0.049 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.031 0.025 -9999.0 0.0 -0.417 1.0 1.0 somite specification 0.027 0.069 -9999.0 0.0 -0.309 9.0 9.0 SHH Np/Cholesterol/PTCH1 0.026 0.04 -9999.0 0.0 -0.257 4.0 4.0 SHH Np/Cholesterol/PTCH2 0.023 0.019 -9999.0 0.0 -0.23 1.0 1.0 SHH Np/Cholesterol/Megalin -0.087 0.124 -9999.0 0.0 -0.229 157.0 157.0 SHH -0.01 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.034 0.062 -9999.0 0.0 -0.416 6.0 6.0 SMO/Vitamin D3 0.036 0.064 0.214 16.0 -0.267 5.0 21.0 SHH Np/Cholesterol/Hhip 0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.204 0.225 -9999.0 0.0 -0.417 193.0 193.0 receptor-mediated endocytosis -0.059 0.116 -9999.0 0.0 -0.312 20.0 20.0 SHH Np/Cholesterol/BOC 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.058 0.084 0.234 50.0 -0.259 4.0 54.0 IHH N/PTCH2 0.051 0.033 -9999.0 0.0 -0.325 1.0 1.0 CDON 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.043 0.067 -9999.0 0.0 -0.384 7.0 7.0 Megalin/LRPAP1 -0.13 0.172 -9999.0 0.0 -0.295 190.0 190.0 PTCH2 0.033 0.024 -9999.0 0.0 -0.417 1.0 1.0 SHH Np/Cholesterol 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.034 0.063 -9999.0 0.0 -0.417 6.0 6.0 HHIP 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0