Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
BCR signaling pathway	125.0	12465.0	99.0	-0.713	0.043	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	121.0	11067.0	91.0	-1.254	1.005	1000.0	-1000.0	-0.051	-1000.0
TCR signaling in naïve CD8+ T cells	106.0	9887.0	93.0	-0.562	0.12	1000.0	-1000.0	-0.031	-1000.0
IL23-mediated signaling events	102.0	6149.0	60.0	-0.759	0.035	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	81.0	2767.0	34.0	-0.147	0.035	1000.0	-1000.0	-0.031	-1000.0
IL12-mediated signaling events	78.0	6837.0	87.0	-0.679	0.113	1000.0	-1000.0	-0.027	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	61.0	4154.0	68.0	-0.574	0.12	1000.0	-1000.0	-0.045	-1000.0
Caspase cascade in apoptosis	59.0	4407.0	74.0	-0.162	0.125	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	55.0	939.0	17.0	-0.221	0.033	1000.0	-1000.0	-0.018	-1000.0
Calcium signaling in the CD4+ TCR pathway	55.0	1711.0	31.0	-0.346	0.035	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling events	55.0	276.0	5.0	-0.08	0.035	1000.0	-1000.0	0.019	-1000.0
IL27-mediated signaling events	52.0	2679.0	51.0	-0.263	0.172	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	51.0	2438.0	47.0	-0.095	0.076	1000.0	-1000.0	-0.027	-1000.0
Ras signaling in the CD4+ TCR pathway	51.0	880.0	17.0	-0.14	0.063	1000.0	-1000.0	-0.007	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	46.0	3440.0	74.0	-0.08	0.08	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in the nascent adherens junction	44.0	3393.0	76.0	-0.092	0.052	1000.0	-1000.0	-0.034	-1000.0
a4b1 and a4b7 Integrin signaling	41.0	207.0	5.0	-0.03	0.011	1000.0	-1000.0	0.02	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	41.0	1874.0	45.0	-0.171	0.073	1000.0	-1000.0	-0.02	-1000.0
Thromboxane A2 receptor signaling	39.0	4147.0	105.0	-0.122	0.057	1000.0	-1000.0	-0.024	-1000.0
amb2 Integrin signaling	38.0	3149.0	82.0	-0.184	0.044	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	38.0	4390.0	114.0	-0.419	0.234	1000.0	-1000.0	-0.035	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3158.0	82.0	-0.069	0.035	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by PI3K	37.0	2192.0	58.0	-0.149	0.06	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	37.0	817.0	22.0	-0.163	0.036	1000.0	-1000.0	-0.011	-1000.0
Class I PI3K signaling events	37.0	2730.0	73.0	-0.377	0.069	1000.0	-1000.0	-0.016	-1000.0
Angiopoietin receptor Tie2-mediated signaling	37.0	3328.0	88.0	-0.207	0.046	1000.0	-1000.0	-0.052	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	36.0	1366.0	37.0	-0.218	0.049	1000.0	-1000.0	-0.015	-1000.0
Endothelins	36.0	3550.0	96.0	-0.147	0.036	1000.0	-1000.0	-0.03	-1000.0
FOXA2 and FOXA3 transcription factor networks	34.0	1571.0	46.0	-0.42	0.04	1000.0	-1000.0	-0.033	-1000.0
Syndecan-1-mediated signaling events	32.0	1099.0	34.0	-0.095	0.035	1000.0	-1000.0	-0.008	-1000.0
Fc-epsilon receptor I signaling in mast cells	32.0	3152.0	97.0	-0.104	0.06	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in keratinocytes	32.0	1407.0	43.0	-0.08	0.037	1000.0	-1000.0	-0.013	-1000.0
S1P4 pathway	32.0	812.0	25.0	-0.111	0.045	1000.0	-1000.0	-0.014	-1000.0
ceramide signaling pathway	30.0	1505.0	49.0	-0.101	0.05	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	29.0	1984.0	68.0	-0.12	0.045	1000.0	-1000.0	-0.031	-1000.0
LPA receptor mediated events	28.0	2889.0	102.0	-0.072	0.045	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	28.0	1922.0	67.0	-0.172	0.046	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	26.0	2025.0	76.0	-0.083	0.107	1000.0	-1000.0	-0.007	-1000.0
Atypical NF-kappaB pathway	26.0	807.0	31.0	-0.136	0.049	1000.0	-1000.0	-0.005	-1000.0
Visual signal transduction: Cones	25.0	982.0	38.0	-0.144	0.043	1000.0	-1000.0	-0.005	-1000.0
Glypican 1 network	24.0	1179.0	48.0	-0.216	0.038	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	23.0	897.0	38.0	-0.036	0.049	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	23.0	1109.0	48.0	-0.03	0.053	1000.0	-1000.0	-0.016	-1000.0
Regulation of p38-alpha and p38-beta	23.0	1266.0	54.0	-0.235	0.072	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	23.0	1220.0	52.0	-0.144	0.047	1000.0	-1000.0	-0.013	-1000.0
Aurora C signaling	21.0	150.0	7.0	-0.056	0.032	1000.0	-1000.0	-0.009	-1000.0
Ceramide signaling pathway	21.0	1602.0	76.0	-0.101	0.079	1000.0	-1000.0	-0.017	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1121.0	52.0	-0.176	0.079	1000.0	-1000.0	-0.016	-1000.0
Ephrin A  reverse signaling	20.0	141.0	7.0	-0.0	0.025	1000.0	-1000.0	-0.0	-1000.0
Paxillin-dependent events mediated by a4b1	20.0	721.0	36.0	-0.04	0.059	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	19.0	1211.0	62.0	-0.103	0.073	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	19.0	1483.0	75.0	-0.185	0.056	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1585.0	86.0	-0.054	0.062	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	17.0	1333.0	76.0	-0.241	0.063	1000.0	-1000.0	-0.032	-1000.0
EPO signaling pathway	17.0	982.0	55.0	-0.038	0.053	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by the Hedgehog family	16.0	852.0	52.0	-0.204	0.058	1000.0	-1000.0	-0.012	-1000.0
Integrins in angiogenesis	16.0	1407.0	84.0	-0.136	0.077	1000.0	-1000.0	-0.019	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1354.0	85.0	-0.037	0.074	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	15.0	1002.0	63.0	-0.175	0.072	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	15.0	1329.0	85.0	-0.054	0.067	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	14.0	1440.0	97.0	-0.299	0.087	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1110.0	78.0	-0.074	0.09	1000.0	-1000.0	-0.029	-1000.0
Cellular roles of Anthrax toxin	13.0	533.0	39.0	-0.122	0.042	1000.0	-1000.0	-0.013	-1000.0
p75(NTR)-mediated signaling	13.0	1673.0	125.0	-0.101	0.088	1000.0	-1000.0	-0.032	-1000.0
BMP receptor signaling	13.0	1126.0	81.0	-0.138	0.074	1000.0	-1000.0	-0.018	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1136.0	83.0	-0.097	0.066	1000.0	-1000.0	-0.013	-1000.0
LPA4-mediated signaling events	12.0	146.0	12.0	-0.047	0.01	1000.0	-1000.0	-0.009	-1000.0
Sphingosine 1-phosphate (S1P) pathway	12.0	342.0	28.0	-0.111	0.066	1000.0	-1000.0	-0.012	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1478.0	120.0	-0.075	0.084	1000.0	-1000.0	-0.036	-1000.0
Noncanonical Wnt signaling pathway	11.0	310.0	26.0	-0.001	0.052	1000.0	-1000.0	-0.017	-1000.0
Syndecan-2-mediated signaling events	11.0	826.0	69.0	-0.172	0.058	1000.0	-1000.0	-0.02	-1000.0
IL1-mediated signaling events	11.0	689.0	62.0	-0.032	0.09	1000.0	-1000.0	-0.019	-1000.0
Ephrin B reverse signaling	11.0	552.0	48.0	-0.101	0.048	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	10.0	658.0	65.0	-0.023	0.06	1000.0	-1000.0	-0.048	-1000.0
Canonical Wnt signaling pathway	10.0	521.0	51.0	-0.027	0.075	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	10.0	225.0	21.0	-0.02	0.055	1000.0	-1000.0	-0.027	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	601.0	61.0	-0.067	0.088	1000.0	-1000.0	-0.039	-1000.0
Canonical NF-kappaB pathway	8.0	312.0	39.0	-0.054	0.073	1000.0	-1000.0	-0.005	-1000.0
TCGA08_rtk_signaling	8.0	209.0	26.0	-0.04	0.082	1000.0	-1000.0	-0.021	-1000.0
TCGA08_retinoblastoma	8.0	70.0	8.0	-0.002	0.027	1000.0	-1000.0	-0.004	-1000.0
Aurora B signaling	8.0	536.0	67.0	-0.097	0.089	1000.0	-1000.0	-0.027	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	389.0	54.0	-0.078	0.064	1000.0	-1000.0	-0.013	-1000.0
mTOR signaling pathway	7.0	372.0	53.0	-0.02	0.058	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	114.0	15.0	-0.004	0.034	1000.0	-1000.0	-0.014	-1000.0
Effects of Botulinum toxin	7.0	194.0	26.0	-0.026	0.045	1000.0	-1000.0	-0.0	-1000.0
HIF-2-alpha transcription factor network	6.0	273.0	43.0	-0.164	0.168	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class I	6.0	663.0	104.0	-0.064	0.081	1000.0	-1000.0	-0.031	-1000.0
Glypican 2 network	6.0	27.0	4.0	0.025	0.036	1000.0	-1000.0	0.021	-1000.0
Insulin Pathway	6.0	455.0	74.0	-0.059	0.083	1000.0	-1000.0	-0.024	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	204.0	33.0	-0.009	0.077	1000.0	-1000.0	-0.023	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.023	-1000.0
Regulation of Androgen receptor activity	6.0	463.0	70.0	-0.057	0.055	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	5.0	362.0	69.0	-0.031	0.054	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	5.0	425.0	85.0	-0.008	0.069	1000.0	-1000.0	-0.027	-1000.0
FoxO family signaling	5.0	350.0	64.0	-0.41	0.095	1000.0	-1000.0	-0.022	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	228.0	44.0	-0.005	0.061	1000.0	-1000.0	-0.016	-1000.0
Wnt signaling	5.0	41.0	7.0	0.007	0.033	1000.0	-1000.0	0.001	-1000.0
Regulation of Telomerase	5.0	578.0	102.0	-0.112	0.077	1000.0	-1000.0	-0.023	-1000.0
VEGFR1 specific signals	5.0	282.0	56.0	-0.047	0.084	1000.0	-1000.0	-0.017	-1000.0
S1P3 pathway	5.0	213.0	42.0	-0.037	0.054	1000.0	-1000.0	-0.012	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	551.0	136.0	-0.114	0.129	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	322.0	68.0	-0.054	0.066	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	522.0	125.0	-0.075	0.087	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PRL	4.0	146.0	34.0	-0.054	0.078	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	4.0	193.0	44.0	-0.011	0.057	1000.0	-1000.0	-0.011	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	211.0	65.0	0.0	0.081	1000.0	-1000.0	-0.021	-1000.0
Arf6 downstream pathway	3.0	162.0	43.0	-0.051	0.064	1000.0	-1000.0	-0.03	-1000.0
S1P1 pathway	3.0	134.0	36.0	-0.0	0.052	1000.0	-1000.0	-0.025	-1000.0
Retinoic acid receptors-mediated signaling	3.0	213.0	58.0	-0.033	0.067	1000.0	-1000.0	-0.02	-1000.0
Syndecan-3-mediated signaling events	3.0	135.0	35.0	-0.018	0.088	1000.0	-1000.0	-0.012	-1000.0
Nongenotropic Androgen signaling	3.0	160.0	52.0	-0.041	0.057	1000.0	-1000.0	-0.015	-1000.0
IGF1 pathway	3.0	189.0	57.0	-0.025	0.085	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	3.0	206.0	54.0	-0.008	0.05	1000.0	-1000.0	-0.008	-1000.0
Coregulation of Androgen receptor activity	2.0	178.0	76.0	-0.015	0.06	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class II	2.0	150.0	75.0	-0.039	0.089	1000.0	-1000.0	-0.016	-1000.0
Aurora A signaling	2.0	124.0	60.0	-0.0	0.075	1000.0	-1000.0	-0.005	-1000.0
PDGFR-alpha signaling pathway	2.0	119.0	44.0	-0.019	0.071	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class III	2.0	102.0	40.0	-0.056	0.057	1000.0	-1000.0	-0.034	-1000.0
Reelin signaling pathway	2.0	155.0	56.0	-0.002	0.079	1000.0	-1000.0	-0.016	-1000.0
Arf6 trafficking events	2.0	206.0	71.0	-0.052	0.064	1000.0	-1000.0	-0.033	-1000.0
FOXM1 transcription factor network	2.0	121.0	51.0	0.008	0.262	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	1.0	48.0	32.0	-0.0	0.064	1000.0	-1000.0	-0.014	-1000.0
Rapid glucocorticoid signaling	1.0	36.0	20.0	-0.009	0.041	1000.0	-1000.0	-0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.007	0.069	1000.0	-1000.0	-0.008	-1000.0
BARD1 signaling events	0.0	38.0	57.0	-0.078	0.091	1000.0	-1000.0	-0.037	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.018	-1000.0	1000.0	-1000.0	-0.003	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.08	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	0.0	9.0	17.0	-0.039	0.041	1000.0	-1000.0	-0.003	-1000.0
TCGA08_p53	0.0	1.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.0	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.0	0.082	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.089	1000.0	-1000.0	0.0	-1000.0
Total	2740	171097	7203	-15.9233802763	-990.356404241	131000	-131000	-2.76169996716	-131000