rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(7), CDKN2A(13), E2F1(3), MDM2(5), MYC(5), PIK3CA(72), PIK3R1(11), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), RB1(13), TBX2(6), TP53(142), TWIST1(2) 8710873 308 200 210 37 74 95 7 43 81 8 4.50e-12 <1.00e-15 <2.58e-13 2 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(4), DNAJC3(3), EIF2S1(2), EIF2S2(2), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), TP53(142) 4197551 171 146 115 8 45 34 2 30 54 6 9.34e-12 1.67e-15 2.58e-13 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(5), CCND1(1), CDK2(3), CDKN1A(3), CDKN2A(13), CFL1(1), E2F1(3), E2F2(4), MDM2(5), NXT1(2), PRB1(6), TP53(142) 3621793 188 157 131 12 50 39 3 27 61 8 1.02e-11 1.89e-15 2.58e-13 4 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(38), CDC25A(6), CDC25B(4), CDC25C(13), CDK2(3), CHEK1(4), MYT1(19), RB1(13), TP53(142), WEE1(4), YWHAH(3) 7559184 249 176 182 22 59 52 6 44 78 10 1.30e-09 2.55e-15 2.58e-13 5 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(38), ATR(18), CDC25C(13), CHEK1(4), CHEK2(8), TP53(142), YWHAH(3) 6857303 226 171 161 20 56 41 5 39 75 10 4.11e-07 2.78e-15 2.58e-13 6 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(5), MAX(3), MYC(5), SP1(6), SP3(3), TP53(142), WT1(3) 3032684 167 151 111 15 44 34 2 28 53 6 1.53e-09 3.00e-15 2.58e-13 7 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(8), ATM(38), BAX(6), BCL2(3), CCND1(1), CCNE1(5), CDK2(3), CDKN1A(3), E2F1(3), MDM2(5), PCNA(2), RB1(13), TIMP3(6), TP53(142) 7778948 238 174 169 23 56 51 5 39 77 10 6.10e-09 3.33e-15 2.58e-13 8 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(26), AKT1(3), ATM(38), BAX(6), CDKN1A(3), CPB2(10), CSNK1A1(3), CSNK1D(2), FHL2(4), HIC1(6), HIF1A(7), HSPA1A(2), IGFBP3(6), MAPK8(6), MDM2(5), NFKBIB(6), NQO1(3), TP53(142) 8909084 278 182 210 28 69 56 7 45 90 11 8.41e-11 3.66e-15 2.58e-13 9 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), CASP3(2), CASP6(1), CASP7(3), CASP9(3), EIF2S1(2), PRKCA(5), PTK2(11), PXN(4), STAT1(10), TLN1(22), TP53(142) 11749843 268 178 201 29 73 58 11 39 78 9 3.77e-10 3.77e-15 2.58e-13 10 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(40), DAXX(10), PAX3(11), PML(12), RARA(3), RB1(13), SIRT1(6), SP100(15), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(142) 8160663 264 173 205 32 80 60 4 39 75 6 1.93e-10 6.11e-15 3.76e-13 11 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(4), HSPA1A(2), IFNG(2), IFNGR1(6), IFNGR2(2), IKBKB(7), JAK2(13), LIN7A(9), NFKB1(7), NFKBIA(1), RB1(13), RELA(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(142), USH1C(4), WT1(3) 7791981 232 165 173 35 57 51 4 46 67 7 2.16e-06 1.68e-12 9.42e-11 12 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(7), ATM(38), BRCA1(16), CDKN1A(3), CHEK1(4), CHEK2(8), JUN(4), MAPK8(6), MDM2(5), MRE11A(5), NFKB1(7), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(5), TP53(142), TP73(5) 12784723 273 183 209 37 62 55 8 51 87 10 1.89e-06 3.52e-09 1.80e-07 13 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(4), MAP2K4(9), MAP3K1(11), MAP3K14(5), MAPK10(5), MCL1(1), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), PARP1(10), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(5), TP53(142), TRADD(2), TRAF1(3), TRAF2(4) 16043126 318 189 250 47 82 63 8 57 100 8 2.98e-08 1.94e-08 9.22e-07 14 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(3), CASP9(3), CHUK(4), GH1(2), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3CA(72), PIK3R1(11), PPP2CA(2), RELA(5), YWHAH(3) 6049760 124 80 85 11 19 61 7 21 15 1 1.98e-08 4.63e-05 0.00204 15 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(11) 311023 11 11 11 0 3 2 1 1 4 0 0.0397 0.000328 0.0135 16 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3E(2), CD3G(1), CD80(4), CD86(6), CTLA4(3), GRB2(4), HLA-DRA(8), ICOS(2), ITK(6), LCK(4), PIK3CA(72), PIK3R1(11), PTPN11(6) 5503459 131 85 91 15 28 61 6 19 16 1 9.07e-07 0.000740 0.0285 17 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(22), HLA-A(16), IL18(1), ITGB1(10), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), LAT(3), MAP2K1(5), MAPK3(1), PAK1(5), PIK3CA(72), PIK3R1(11), PTK2B(16), PTPN6(4), SYK(7), VAV1(9) 7998705 191 103 134 26 30 75 5 32 41 8 4.46e-06 0.00171 0.0619 18 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(4), KLK2(1), NTRK1(10), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), SHC1(7), SOS1(7) 6688969 139 86 99 15 32 63 7 17 19 1 5.72e-08 0.00467 0.160 19 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(3), CASP9(3), CDC42(1), CHUK(4), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3CA(72), PIK3R1(11), RAF1(10), RALBP1(8), RALGDS(14), RELA(5), RHOA(17) 8198178 167 99 121 23 35 76 6 29 20 1 1.25e-07 0.00738 0.239 20 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(8), GRB2(4), ILK(8), ITGB1(10), MAPK1(3), MAPK3(1), PDPK1(2), PIK3CA(72), PIK3R1(11), PTEN(29), PTK2(11), SHC1(7), SOS1(7) 8260099 176 93 125 21 32 67 8 26 37 6 2.60e-07 0.0163 0.502 21 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(7), ATM(38), ATR(18), CCNA1(6), CCND1(1), CCNE1(5), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), CDKN2A(13), E2F1(3), GSK3B(5), HDAC1(5), RB1(13), SKP2(5), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TP53(142) 12966099 299 185 237 51 74 66 6 53 90 10 2.38e-05 0.0181 0.515 22 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(3), GRB2(4), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), NTRK1(10), PIK3CA(72), PIK3R1(11), PLCG1(19), RPS6KA1(9), SHC1(7) 8123541 166 94 125 21 42 72 10 19 22 1 1.54e-08 0.0184 0.515 23 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(38), ATR(18), BRCA1(16), BRCA2(40), CHEK1(4), CHEK2(8), FANCA(7), FANCC(5), FANCD2(13), FANCE(7), FANCG(4), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(9), RAD51(1), RAD9A(4), TP53(142), TREX1(3) 18920649 335 185 267 45 71 72 9 66 106 11 1.87e-06 0.0370 0.991 24 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(5), GH1(2), GHR(6), IGF1(4), IGF1R(16), PIK3CA(72), PIK3R1(11), SHC1(7), SOD2(1) 5717310 127 79 88 22 21 63 6 22 14 1 0.000112 0.0854 1.000 25 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), JUN(4), KLK2(1), MAP2K1(5), MAPK3(1), MAPK8(6), NGFR(4), PIK3CA(72), PIK3R1(11), PLCG1(19), RAF1(10), SHC1(7), SOS1(7) 8211313 161 92 118 23 39 67 7 26 20 2 5.72e-07 0.135 1.000 26 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), FBXW7(28), RB1(13), TFDP1(5) 3544666 81 55 69 11 27 21 2 10 21 0 0.000399 0.157 1.000 27 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(72), PIK3R1(11), PLCB1(18), PLCG1(19), PRKCA(5), VAV1(9) 5520278 137 85 96 23 31 62 6 18 19 1 0.000101 0.160 1.000 28 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(8), AKT1(3), ANXA1(2), CALM1(2), CALM2(2), GNAS(27), GNB1(1), GNGT1(3), NFKB1(7), NOS3(10), NPPA(2), NR3C1(6), PIK3CA(72), PIK3R1(11), RELA(5), SYT1(4) 7710531 165 98 120 25 45 67 4 27 21 1 1.15e-05 0.255 1.000 29 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NFKB1(7), PIK3CA(72), PIK3R1(11), RB1(13), RELA(5), SP1(6) 8328353 149 90 106 22 24 73 5 21 25 1 6.08e-06 0.300 1.000 30 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(8), AKT3(6), BPNT1(4), GRB2(4), ILK(8), MAPK1(3), MAPK3(1), PDK1(3), PIK3CA(72), PIK3CD(11), PTEN(29), PTK2B(16), RBL2(8), SHC1(7), SOS1(7) 8761566 190 96 141 29 47 70 4 28 36 5 2.66e-05 0.312 1.000 31 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), BCL2(3), EGFR(15), IGF1R(16), MYC(5), POLR2A(19), PPP2CA(2), PRKCA(5), RB1(13), TEP1(29), TERF1(5), TERT(4), TNKS(19), TP53(142), XRCC5(10) 12118487 290 172 229 62 72 74 7 50 81 6 0.000151 0.368 1.000 32 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(8), FMOD(10), KERA(1), LUM(7) 1561475 27 24 27 4 12 4 1 7 3 0 0.0696 0.403 1.000 33 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(1), CCNE1(5), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3CA(72), PIK3R1(11), RAF1(10), RB1(13), RELA(5), TFDP1(5) 8688399 155 89 114 23 28 74 6 24 22 1 1.88e-06 0.403 1.000 34 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(15), HLA-DRA(8) 1021938 25 23 16 5 6 4 0 3 12 0 0.570 0.415 1.000 35 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(16), AOC2(6), AOC3(15), CES1(7), ESD(1) 2594728 45 32 38 8 10 11 1 7 15 1 0.206 0.450 1.000 36 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(8), GSTZ1(3), HGD(4) 953469 15 13 14 3 4 3 0 4 4 0 0.377 0.536 1.000 37 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(1) 706305 7 7 7 1 2 2 1 1 1 0 0.308 0.659 1.000 38 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), INSR(14), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PIK3CA(72), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SLC2A4(4), SOS1(7), SRF(2) 10945370 204 106 158 31 46 78 7 28 42 3 2.72e-07 0.667 1.000 39 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(43), AXIN1(9), CCND1(1), CD14(2), CTNNB1(22), DVL1(7), FZD1(10), GJA1(11), GNAI1(1), GSK3B(5), IRAK1(6), LBP(1), LEF1(8), LY96(4), MYD88(4), NFKB1(7), PDPK1(2), PIK3CA(72), PIK3R1(11), PPP2CA(2), RELA(5), TIRAP(1), TLR4(21), TOLLIP(5), WNT1(8) 13185826 271 136 219 49 50 92 10 54 54 11 4.27e-06 0.692 1.000 40 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), CASP3(2), CASP8(18), CFL1(1), CFLAR(1), PDE6D(1) 1664357 26 22 23 5 3 5 3 5 10 0 0.502 0.718 1.000 41 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(5), GRIA2(23), JUND(2), PPP1R1B(1) 1603188 33 27 33 6 7 10 1 10 5 0 0.0641 0.722 1.000 42 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 488715 3 3 3 1 0 1 1 0 1 0 0.822 0.742 1.000 43 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(38), ATR(18), BRCA1(16), CCNB1(3), CDC25A(6), CDC25B(4), CDC25C(13), CDC34(2), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), EP300(21), MDM2(5), MYT1(19), PRKDC(40), RPS6KA1(9), TP53(142), WEE1(4), YWHAH(3), YWHAQ(2) 17954435 363 194 294 67 96 84 9 67 96 11 3.80e-05 0.747 1.000 44 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD28(2), CD3E(2), CD3G(1), CD4(15) 1381325 24 22 15 5 2 5 1 3 13 0 0.736 0.747 1.000 45 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(15), CD80(4), HLA-DRA(8), IL10(2), IL4(1) 1707909 32 28 23 6 10 4 0 5 13 0 0.369 0.769 1.000 46 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(15), CD8A(4), CSF1(2), CSF3(2), EPO(1), IL11(3), IL3(1), IL4(1), IL7(1), IL8(2) 2609601 32 28 23 4 6 6 1 6 13 0 0.151 0.777 1.000 47 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(2), CCR3(6), HLA-DRA(8), IL3(1) 1308153 18 16 18 4 9 6 0 2 1 0 0.154 0.778 1.000 48 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(6), CD4(15), HLA-DRA(8), IL1B(3), IL4(1), IL5RA(4) 2294671 38 30 29 9 10 7 0 7 14 0 0.410 0.798 1.000 49 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(5), LIPT1(5) 652455 10 9 8 2 2 3 0 0 5 0 0.532 0.819 1.000 50 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9) 2419403 33 24 32 6 4 8 0 14 6 1 0.158 0.856 1.000 51 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(4), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), GHR(6), IRS1(24), MAPK1(3), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3CA(72), PIK3R1(11), PRKCA(5), PTEN(29), RPS6KB1(5) 12081063 228 110 176 33 43 83 9 36 50 7 1.93e-06 0.880 1.000 52 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(4), CD3E(2), CD3G(1), CD4(15), CD58(6), CD8A(4), CSF3(2), IL3(1), IL8(2), KITLG(3) 2650793 43 35 33 9 5 10 2 7 19 0 0.320 0.888 1.000 53 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDK2(3), CUL1(22), E2F1(3), RB1(13), RBX1(1), SKP2(5), TFDP1(5), UBE2M(1) 3687047 58 41 56 10 11 21 2 10 14 0 0.0122 0.898 1.000 54 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(8), BAD(3), BAK1(4), BAX(6), BCL2(3), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(2), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP8(18), CASP9(3), CHUK(4), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(8), IKBKB(7), IRF1(5), IRF2(17), IRF3(3), IRF4(7), IRF5(4), IRF6(5), IRF7(1), JUN(4), LTA(4), MAP2K4(9), MAP3K1(11), MAPK10(5), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), NFKBIB(6), PLEKHG5(8), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFSF10(5), TP53(142), TP73(5), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4) 24612744 431 201 360 81 111 87 15 78 130 10 2.17e-06 0.922 1.000 55 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(1), ALDOB(6), ALDOC(5), TPI1(1) 1682865 19 19 19 4 3 7 1 6 2 0 0.255 0.937 1.000 56 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP19(10), SRP54(6), SRP68(5), SRP72(10), SRP9(1), SRPR(12) 3233319 47 35 47 7 14 14 1 7 11 0 0.0308 0.943 1.000 57 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(9), IDI1(2), SQLE(5) 1363502 18 13 17 3 4 4 1 3 6 0 0.191 0.944 1.000 58 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(15), PIK3CA(72), PIK3R1(11), WASL(3) 5751838 119 76 80 23 18 65 5 16 14 1 0.00119 0.946 1.000 59 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12), XYLT2(35) 2793355 75 53 48 16 24 13 1 5 32 0 0.242 0.951 1.000 60 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12), XYLT2(35) 2793355 75 53 48 16 24 13 1 5 32 0 0.242 0.951 1.000 61 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(5), IL8(2), SLPI(3) 735928 10 9 9 4 3 2 0 2 3 0 0.764 0.955 1.000 62 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(9), GBA3(2), GGT1(6), SHMT1(4), SHMT2(9) 2348712 32 29 29 7 11 4 1 4 11 1 0.212 0.962 1.000 63 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(5), CCL2(1), CSF1(2), LDLR(11), LPL(7) 2287815 26 24 26 7 10 4 1 5 5 1 0.212 0.968 1.000 64 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT1(3), AKT2(8), AKT3(6), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CAPN1(5), CAPN2(8), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CASP9(3), CFLAR(1), CHUK(4), CSF2RB(9), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL3(1), IL3RA(5), IRAK1(6), IRAK2(7), IRAK3(6), IRAK4(3), MAP3K14(5), MYD88(4), NFKB1(7), NFKB2(7), NFKBIA(1), NTRK1(10), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(5), TP53(142), TRADD(2), TRAF2(4) 35802837 645 225 519 114 170 158 21 109 173 14 1.12e-10 0.968 1.000 65 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(4) 907276 9 9 9 2 5 0 0 2 2 0 0.459 0.974 1.000 66 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(3), GALT(1), TGDS(4), UGDH(5), UXS1(4) 1650101 17 16 17 4 6 6 1 3 1 0 0.229 0.975 1.000 67 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(22), CD3E(2), CD3G(1), GZMB(3), HLA-A(16), ICAM1(2), ITGAL(16), ITGB2(6), PRF1(8) 3754776 76 49 61 17 13 13 2 10 31 7 0.364 0.979 1.000 68 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4E(2), EIF4EBP1(2), GSK3B(5), IGF1(4), IGF1R(16), INPPL1(24), PDPK1(2), PIK3CA(72), PIK3R1(11), PPP2CA(2), PTEN(29), RPS6(1), RPS6KB1(5) 8431780 191 94 138 31 35 73 6 30 42 5 7.45e-05 0.981 1.000 69 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(6), SHMT1(4), SHMT2(9) 1767088 21 21 18 7 7 1 0 2 10 1 0.654 0.981 1.000 70 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(10) 870608 10 6 10 3 3 3 0 4 0 0 0.564 0.983 1.000 71 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(7), NR3C1(6), PPARG(4), RXRA(6), TNF(3) 2484079 29 27 27 7 7 2 4 8 8 0 0.344 0.984 1.000 72 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(1), FYN(10), JUN(4), MAPK14(1), THBS1(16) 3182545 36 29 35 7 10 11 1 8 5 1 0.0773 0.988 1.000 73 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(8), ATM(38), ATR(18), BAI1(14), BAX(6), BID(2), CASP3(2), CASP8(18), CASP9(3), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CD82(3), CDK2(3), CDK6(4), CDKN1A(3), CDKN2A(13), CHEK1(4), CHEK2(8), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(3), IGF1(4), IGFBP3(6), LRDD(6), MDM2(5), MDM4(5), PERP(3), PPM1D(9), PTEN(29), RCHY1(1), RFWD2(7), RPRM(5), RRM2(4), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(2), SESN2(2), SESN3(4), SFN(1), SIAH1(2), STEAP3(9), THBS1(16), TNFRSF10B(2), TP53(142), TP53I3(1), TP73(5), TSC2(12), ZMAT3(4) 27994530 491 214 409 100 126 109 11 91 138 16 2.93e-05 0.989 1.000 74 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), EHHADH(7), GCDH(8), HADHA(4), SDHB(4), SDS(4) 3350753 40 29 37 7 9 15 2 3 10 1 0.0439 0.989 1.000 75 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(6), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MPL(5), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), THPO(6) 12879034 227 106 180 33 49 85 10 39 42 2 2.18e-07 0.993 1.000 76 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(2), IL12A(2), IL12B(2), IL18(1) 1274062 11 10 10 4 1 3 1 4 2 0 0.816 0.993 1.000 77 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(3), CDC42(1), DLD(4), DUSP10(8), DUSP4(1), DUSP8(1), GAB1(3), GCK(4), IL1R1(4), JUN(4), MAP2K4(9), MAP2K5(1), MAP2K7(24), MAP3K1(11), MAP3K10(8), MAP3K11(10), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK10(5), MAPK7(6), MAPK8(6), MAPK9(3), MYEF2(9), NFATC3(4), NR2C2(3), PAPPA(25), SHC1(7), TP53(142), TRAF6(6), ZAK(8) 21607009 398 185 336 77 113 92 17 64 104 8 2.10e-06 0.994 1.000 78 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(3), GALT(1), TGDS(4), UGDH(5), UGP2(7), UXS1(4) 2102519 24 21 22 5 8 6 1 4 5 0 0.223 0.995 1.000 79 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(8), ARHGAP5(18), ARHGDIB(1), CASP1(4), CASP10(6), CASP3(2), CASP8(18), CASP9(3), GZMB(3), JUN(4), PRF1(8) 5534602 75 51 64 13 12 11 6 15 30 1 0.184 0.995 1.000 80 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(9), GGPS1(1), IDI1(2), IDI2(1), SQLE(5) 1827582 20 14 19 4 4 5 1 3 7 0 0.286 0.995 1.000 81 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(8), CXCR4(1), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(10), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PTK2B(16), PXN(4), RAF1(10), RELA(5) 11836095 197 105 153 31 49 70 9 31 37 1 8.50e-07 0.996 1.000 82 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(5), SPCS1(3), SPCS3(2) 1319135 13 11 13 5 3 1 0 8 1 0 0.761 0.998 1.000 83 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(5), ACAT2(4), OXCT1(8) 1450639 17 16 17 7 2 8 0 3 3 1 0.859 0.998 1.000 84 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(43), CDH1(30), CREBBP(40), EP300(21), MAP2K1(5), MAP3K7(10), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14) 11024443 187 109 178 38 41 52 7 36 42 9 0.00363 0.998 1.000 85 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(6), CDC25B(4), CDC25C(13), CSK(7), GRB2(4), PRKCA(5), PTPRA(11), SRC(3) 3964120 56 41 52 10 17 13 0 8 17 1 0.0462 0.999 1.000 86 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(8), CBS(6), CTH(2), MUT(6) 2096137 25 22 24 9 6 4 1 2 11 1 0.790 0.999 1.000 87 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(3), CREBBP(40), EP300(21), FYN(10), IL2RG(6), IL7(1), IL7R(9), JAK1(12), JAK3(13), LCK(4), NMI(1), PIK3CA(72), PIK3R1(11), PTK2B(16), STAT5A(3), STAT5B(14) 11996628 236 102 189 37 55 90 5 41 43 2 5.32e-07 0.999 1.000 88 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(2), CDC25A(6), CDC25B(4), CDC25C(13), MNAT1(3), SHH(4), XPO1(7) 3698334 42 29 38 8 10 10 1 9 11 1 0.155 0.999 1.000 89 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(3), BCR(11), CRKL(1), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), MYC(5), PIK3CA(72), PIK3R1(11), RAF1(10), SOS1(7), STAT1(10), STAT5A(3), STAT5B(14) 12062071 204 101 157 35 39 84 6 33 39 3 4.67e-06 0.999 1.000 90 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(6), CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), SKP2(5), TFDP1(5) 3668575 64 46 62 15 13 25 2 12 12 0 0.0421 1.000 1.000 91 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(16), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PIK3CA(72), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2) 10655005 206 103 160 38 46 77 7 34 39 3 3.11e-05 1.000 1.000 92 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(6), ERBB4(47), NRG2(8), NRG3(17), PRKCA(5), PSEN1(3) 3865364 86 60 81 23 22 22 8 20 13 1 0.177 1.000 1.000 93 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(8), GLS2(7), GLUD1(2), GLUD2(11) 1951070 28 21 28 7 7 8 0 11 2 0 0.287 1.000 1.000 94 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), DFFA(4), DFFB(3), GZMB(3), HMGB2(4), TOP2A(5), TOP2B(10) 3795203 34 25 33 5 5 10 1 8 10 0 0.158 1.000 1.000 95 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(3), FOS(1), JUN(4), KEAP1(10), MAFF(1), MAPK1(3), MAPK14(1), MAPK8(6), NFE2L2(1), PRKCA(5) 3802548 35 28 35 9 10 13 2 3 6 1 0.131 1.000 1.000 96 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(4), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3CA(72), PIK3R1(11), PPP2CA(2), PTEN(29), RPS6(1), RPS6KB1(5), TSC1(7), TSC2(12) 11849631 215 102 165 35 43 79 8 37 42 6 2.59e-05 1.000 1.000 97 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(2), IL1B(3), MST1(7), MST1R(14), TNF(3) 2815221 30 23 30 5 10 5 0 7 8 0 0.104 1.000 1.000 98 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CASP9(3), DFFA(4), DFFB(3), DIABLO(1) 5761666 67 44 58 11 14 15 3 14 21 0 0.0999 1.000 1.000 99 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), MIOX(5), UGDH(5) 3647197 55 39 47 14 10 15 0 13 17 0 0.329 1.000 1.000 100 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(3), GRB2(4), IGF1R(16), IRS1(24), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(72), PIK3R1(11), RAF1(10), SHC1(7), SOS1(7), YWHAH(3) 8153449 169 95 126 33 39 73 6 23 26 2 0.000191 1.000 1.000 101 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3E(2), CD3G(1), IFNG(2), IL2RA(3), IL4(1), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), TOB1(1), TOB2(5) 4545011 59 45 59 14 12 18 6 11 12 0 0.131 1.000 1.000 102 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(4), CALM1(2), CALM2(2), ELK1(3), FCER1A(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP2K4(9), MAP2K7(24), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PAK2(7), PIK3CA(72), PIK3R1(11), PLA2G4A(6), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9) 18486826 317 127 269 55 99 104 11 44 56 3 6.36e-09 1.000 1.000 103 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(1), FOSL2(8), IFNAR1(8), IFNAR2(7), IFNB1(3), MAPK8(6), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(6) 4754183 61 46 61 14 15 19 1 10 14 2 0.0884 1.000 1.000 104 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(4), ACADS(4), ACAT1(5), HADHA(4) 2318194 19 15 18 5 6 5 0 2 5 1 0.319 1.000 1.000 105 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(38), CDC25A(6), CDC25B(4), CDC25C(13), CHEK1(4), MYT1(19), WEE1(4), YWHAH(3) 5918396 91 60 81 21 21 19 3 19 25 4 0.275 1.000 1.000 106 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(1), AASS(7), KARS(5) 2025504 18 14 18 5 4 6 1 6 1 0 0.423 1.000 1.000 107 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(2), CCL2(1), CCR5(4), CXCR4(1), FOS(1), GNAQ(4), JUN(4), MAPK14(1), MAPK8(6), PLCG1(19), PRKCA(5), PTK2B(16), SYT1(4) 5936561 70 51 68 15 26 18 3 10 12 1 0.0255 1.000 1.000 108 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(13), SP1(6), SP3(3) 2854552 25 21 24 8 3 12 0 4 6 0 0.490 1.000 1.000 109 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(9), FH(3), IDH1(2), IDH2(4), MDH1(3), SDHB(4), SUCLA2(4) 3823863 37 26 34 7 15 9 0 5 8 0 0.0769 1.000 1.000 110 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(31), GNA12(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8) 4333423 58 42 53 12 11 16 2 8 19 2 0.143 1.000 1.000 111 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), GORASP1(4), MAP2K4(9), MAP2K7(24), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK5(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PIK3CA(72), PIK3CD(11), PIK3R1(11), SYT1(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6) 14404772 239 113 196 40 73 81 8 31 42 4 9.59e-08 1.000 1.000 112 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(5), SNAP25(2), STX1A(3), VAMP2(2) 1400328 16 15 15 5 3 2 1 5 5 0 0.708 1.000 1.000 113 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(3), CREBBP(40), DFFA(4), DFFB(3), GZMA(2), GZMB(3), HMGB2(4), PRF1(8), SET(5) 4536200 74 49 73 19 23 19 2 15 15 0 0.115 1.000 1.000 114 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(5), HADH(3), HADHA(4), HADHB(5), HSD17B4(6), MECR(4), PPT1(6), PPT2(4) 3636190 37 24 36 8 8 15 3 4 7 0 0.0448 1.000 1.000 115 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(5), ACAT1(5), ACAT2(4), EHHADH(7), HADHA(4), HADHB(5), SDS(4) 3589460 37 24 36 9 6 16 2 3 9 1 0.170 1.000 1.000 116 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(2), EPO(1), FLT3(10), IGF1(4), IL11(3), IL1A(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(8) 3560367 44 33 43 10 12 11 1 12 8 0 0.136 1.000 1.000 117 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(12), PDXK(3), PDXP(1), PSAT1(5) 2075630 21 16 21 9 2 7 0 7 4 1 0.773 1.000 1.000 118 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CHRNB1(4), CHRNG(4), MUSK(13), PIK3CA(72), PIK3R1(11), PTK2(11), PTK2B(16), RAPSN(4), SRC(3), TERT(4), YWHAH(3) 7022776 151 90 112 30 38 62 9 23 18 1 0.000200 1.000 1.000 119 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(7), HADHA(4), SDS(4) 2082074 16 13 15 5 4 5 1 2 4 0 0.418 1.000 1.000 120 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(5) 1128324 10 10 10 7 4 3 0 2 1 0 0.925 1.000 1.000 121 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 5671490 81 49 72 19 14 20 0 23 23 1 0.178 1.000 1.000 122 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(2), BIRC3(6), CASP8(18), FADD(1), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 3584868 47 37 44 15 8 8 4 8 18 1 0.758 1.000 1.000 123 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(40), EP300(21), ESR1(9), MAPK1(3), MAPK3(1), PELP1(6), SRC(3) 6296008 83 54 81 19 31 22 2 13 14 1 0.0249 1.000 1.000 124 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(4), MAP3K14(5), MAPK14(1), MAPK8(6), NFKB1(7), RELA(5), TNFRSF13B(5), TNFRSF13C(4), TNFRSF17(1), TNFSF13B(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6) 6232278 57 44 57 11 12 16 2 10 15 2 0.0711 1.000 1.000 125 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(12), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(3), APOBEC3F(2), APOBEC3G(2), APOBEC4(1) 3143328 27 20 27 6 9 6 3 5 4 0 0.241 1.000 1.000 126 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(9), NDUFS2(5), NDUFV1(5) 2969101 34 26 33 7 6 8 1 8 11 0 0.418 1.000 1.000 127 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(2), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11) 2599369 36 28 35 10 13 9 0 9 5 0 0.226 1.000 1.000 128 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCS(2), UPB1(4) 5982354 70 45 67 14 13 18 3 19 17 0 0.0217 1.000 1.000 129 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(5), COQ5(1), COQ6(3), COQ7(3), NDUFA12(2), NDUFA13(3), NDUFB11(2) 1713010 19 17 19 8 7 5 1 3 3 0 0.773 1.000 1.000 130 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(8), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP7(3), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(3), PRF1(8), SCAP(12), SREBF1(12), SREBF2(11) 7778438 102 64 94 20 27 20 5 21 28 1 0.0736 1.000 1.000 131 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AGPS(2), CHPT1(3), ENPP2(9), ENPP6(6), PAFAH1B1(12), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4) 9952044 138 68 130 26 40 38 4 25 31 0 0.00225 1.000 1.000 132 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(9), ACO1(8), ACO2(9), ACSS1(12), ACSS2(10), FH(3), IDH1(2), IDH2(4), MDH1(3), SUCLA2(4) 5715576 64 41 60 14 22 13 3 10 16 0 0.0685 1.000 1.000 133 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(15), CSF1(2), CSF3(2), HLA-DRA(8), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(2), IL12B(2), IL13(2), IL1A(2), IL3(1), IL4(1), IL7(1), IL8(2), LTA(4), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3) 5717306 77 56 68 21 19 18 2 17 21 0 0.351 1.000 1.000 134 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(10), SNCA(1), SNCAIP(13), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1) 2761315 41 32 40 14 11 12 1 8 8 1 0.422 1.000 1.000 135 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(4), FOS(1), JUN(4), MAPK3(1), OPRK1(14), POLR2A(19), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5533905 77 54 72 19 20 24 2 15 16 0 0.0612 1.000 1.000 136 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(26), ABCB11(9), ABCB4(24), ABCC1(15), ABCC3(11), GSTP1(1) 6158288 86 59 83 22 21 20 4 18 20 3 0.120 1.000 1.000 137 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(4), PAPSS1(6), PAPSS2(5), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3) 2625444 28 23 28 7 11 10 0 3 4 0 0.289 1.000 1.000 138 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 3425297 56 35 48 19 12 13 0 11 20 0 0.726 1.000 1.000 139 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 3425297 56 35 48 19 12 13 0 11 20 0 0.726 1.000 1.000 140 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(23), CPT1A(9), LEP(2), LEPR(13), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5) 6213129 79 48 77 17 21 15 3 21 17 2 0.124 1.000 1.000 141 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(10), F13A1(14), F2(9), F2R(3), FGA(9), FGB(4), FGG(3), PLAT(7), PLAU(7), PLG(14), SERPINB2(8), SERPINE1(3) 5760920 91 58 83 26 27 13 7 24 20 0 0.292 1.000 1.000 142 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(6), CDKN1A(3), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(3), NGFR(4), NTRK1(10), PIK3CA(72), PIK3CD(11), SHC1(7), SOS1(7) 6922327 146 89 105 31 39 64 5 26 12 0 0.000492 1.000 1.000 143 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(3), BAX(6), BCL2(3), CASP8(18), FADD(1), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), NFKB1(7), NSMAF(9), RAF1(10), RELA(5), RIPK1(2), SMPD1(8), TNFRSF1A(6), TRADD(2), TRAF2(4) 8800908 119 64 108 27 35 22 5 17 38 2 0.0676 1.000 1.000 144 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), PDGFA(2), PDGFRA(15), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3) 15006400 249 113 203 46 59 95 9 37 47 2 3.45e-06 1.000 1.000 145 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(6), F13B(16), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(6), HSD17B7(3), HSD3B1(4), HSD3B2(3) 3473806 45 37 45 14 8 14 3 13 7 0 0.300 1.000 1.000 146 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(19), PRKCA(5), PTK2B(16) 2899870 45 37 44 12 22 8 2 4 9 0 0.199 1.000 1.000 147 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(11), BMPR1A(5), BMPR1B(7), BMPR2(16) 2689015 39 33 36 10 9 8 2 4 14 2 0.469 1.000 1.000 148 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(3), GLS(8), GLUD1(2), OAT(2) 2367269 19 16 19 7 5 4 0 6 4 0 0.665 1.000 1.000 149 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(5), BRAF(16), CAMP(2), CREB1(3), CREB3(7), CREB5(5), MAPK1(3), RAF1(10), SNX13(7), SRC(3), TERF2IP(5) 4797663 70 47 64 18 18 15 1 17 19 0 0.279 1.000 1.000 150 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(18), DIAPH1(11), FYN(10), GSN(11), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), MYLK(32), PIK3CA(72), PIK3R1(11), PTK2(11), PXN(4), RAF1(10), ROCK1(18), SHC1(7), SRC(3), TLN1(22) 16023433 275 117 215 50 63 92 13 49 53 5 8.21e-06 1.000 1.000 151 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(5), ACOX3(11), FADS2(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6) 4355969 58 44 53 18 23 10 3 14 8 0 0.414 1.000 1.000 152 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(27), CR2(22), FCGR2B(1), HLA-DRA(8), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19) 6527237 105 65 92 29 26 32 0 23 24 0 0.183 1.000 1.000 153 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), IDI1(2), LSS(9), MVD(2), MVK(13), NQO1(3), NQO2(3), PMVK(1), SC5DL(4), SQLE(5), VKORC1(1) 4721949 67 38 57 16 16 14 1 16 20 0 0.196 1.000 1.000 154 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(8), DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), HMGCS1(2), IDI1(2), LSS(9), MVD(2), MVK(13), NSDHL(3), PMVK(1), SC4MOL(4), SC5DL(4), SQLE(5) 5632435 77 45 67 20 17 15 2 18 25 0 0.304 1.000 1.000 155 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(6), EIF1(1), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), ELAVL1(9), FLT1(16), FLT4(24), HIF1A(7), KDR(13), NOS3(10), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PXN(4), SHC1(7), VHL(2) 14585288 253 112 208 47 68 90 12 40 42 1 2.80e-06 1.000 1.000 156 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), ESRRA(2), HDAC5(11), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PPARA(4), PPP3CA(10), PPP3CB(6), PPP3CC(5), SLC2A4(4), SYT1(4), YWHAH(3) 8662424 104 70 101 27 32 24 6 21 21 0 0.0712 1.000 1.000 157 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(6), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), ILVBL(5), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCDC(1), PPCS(2), UPB1(4), VNN1(4) 7431209 86 51 83 17 22 20 3 23 18 0 0.00994 1.000 1.000 158 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPX1(1), PRKCE(14) 3377064 74 50 73 27 18 15 8 26 7 0 0.514 1.000 1.000 159 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(7), B3GAT2(6), B3GAT3(4), B4GALT7(5), CHPF(2), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST3(3), CHST7(7), CHSY1(6), DSE(6), UST(9), XYLT1(12), XYLT2(35) 5982856 116 62 89 27 44 24 2 12 34 0 0.0933 1.000 1.000 160 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(43), AXIN1(9), BTRC(9), CCND1(1), CREBBP(40), CSNK1A1(3), CSNK1D(2), CSNK2A1(6), CTBP1(3), CTNNB1(22), DVL1(7), FZD1(10), GSK3B(5), HDAC1(5), MAP3K7(10), MYC(5), NLK(13), PPARD(8), PPP2CA(2), TLE1(9), WIF1(2), WNT1(8) 12561754 222 106 198 53 62 44 8 33 66 9 0.0384 1.000 1.000 161 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), CDO1(1), CSAD(8), GAD1(7), GAD2(9), GGT1(6) 2466206 35 29 34 12 17 5 1 8 4 0 0.382 1.000 1.000 162 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(4), CHST11(4), CHST12(5), CHST13(4), PAPSS1(6), PAPSS2(5), SULT1A1(6), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3) 3956462 47 34 46 13 22 12 1 8 4 0 0.152 1.000 1.000 163 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(4), DAB1(9), FYN(10), LRP8(5), RELN(47), VLDLR(6) 6019362 83 54 82 24 23 30 3 16 11 0 0.0869 1.000 1.000 164 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(6), CDKN1A(3), EPO(1), EPOR(3), GRIN1(8), HIF1A(7), JAK2(13), NFKB1(7), NFKBIA(1), RELA(5), SOD2(1) 5428608 55 37 54 14 8 17 2 10 17 1 0.285 1.000 1.000 165 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(7), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(7) 2426528 36 33 35 13 18 4 2 8 4 0 0.535 1.000 1.000 166 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(4), HBXIP(1), PTK2B(16), SHC1(7), SOS1(7), SRC(3) 3796620 41 29 41 11 13 10 0 8 10 0 0.346 1.000 1.000 167 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(6), GRB2(4), INSR(14), IRS1(24), JAK2(13), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), PTPN6(4), RAF1(10), RPS6KA1(9), SHC1(7), SLC2A4(4), SOCS1(1), SOS1(7), SRF(2), STAT5A(3), STAT5B(14) 14205723 240 108 193 47 58 95 8 33 43 3 1.72e-05 1.000 1.000 168 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(8), BAD(3), BAK1(4), BAX(6), BCL10(2), BCL2(3), BCL2L11(1), BID(2), CASP8AP2(10), CASP9(3), CES1(7) 4675335 49 30 44 14 15 14 1 9 9 1 0.396 1.000 1.000 169 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(13), AP2A1(9), AP2M1(7), BIN1(4), CALM1(2), CALM2(2), DNM1(5), EPN1(5), EPS15(2), PICALM(2), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYNJ1(10), SYNJ2(17), SYT1(4) 9305231 103 65 95 24 27 21 3 24 28 0 0.0536 1.000 1.000 170 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(15), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF5(6), GSK3B(5), PPP1CA(2) 4952517 51 40 51 13 10 15 1 14 11 0 0.262 1.000 1.000 171 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3) 7112853 87 55 85 23 27 22 3 17 17 1 0.176 1.000 1.000 172 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(3), ALAS2(12), CPO(5), FECH(6), GATA1(3), HBB(2), HMBS(3), UROD(1), UROS(4) 3377482 43 34 43 11 10 11 3 12 7 0 0.303 1.000 1.000 173 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(11), MBTPS1(12), MBTPS2(4), SCAP(12), SREBF1(12), SREBF2(11) 5077584 64 45 61 18 22 15 1 11 14 1 0.233 1.000 1.000 174 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), EHHADH(7), HADHA(4), SDS(4) 5216751 71 39 62 24 16 18 0 13 24 0 0.627 1.000 1.000 175 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PCYT1A(9), PCYT1B(6), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6) 6030990 80 47 75 20 19 23 3 13 21 1 0.131 1.000 1.000 176 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), JUN(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(1), PLCB1(18), PRKCA(5), RAF1(10), RELA(5), TNF(3) 6678768 71 50 68 20 20 15 1 20 15 0 0.236 1.000 1.000 177 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(16), KHK(2), LCT(22), MPI(3), PGM1(3), PYGL(8), PYGM(14), TPI1(1), TREH(3) 5752710 72 52 72 21 32 18 2 8 12 0 0.161 1.000 1.000 178 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(43), ASAH1(4), CAMP(2), CASP3(2), CERK(6), CREB1(3), CREB3(7), CREB5(5), CXCL2(2), DAG1(13), EPHB2(12), FOS(1), GNAQ(4), ITPKA(2), ITPKB(11), JUN(4), MAP2K4(9), MAP2K7(24), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3) 12237885 192 93 187 42 58 46 3 32 44 9 0.00221 1.000 1.000 179 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4) 6451457 104 61 85 26 25 22 3 19 34 1 0.320 1.000 1.000 180 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4) 6451457 104 61 85 26 25 22 3 19 34 1 0.320 1.000 1.000 181 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4) 6451457 104 61 85 26 25 22 3 19 34 1 0.320 1.000 1.000 182 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(7), SHMT1(4) 6863402 111 64 92 27 28 24 4 19 35 1 0.215 1.000 1.000 183 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), GRB2(4), GSK3A(3), GSK3B(5), IL4R(3), IRS1(24), IRS2(6), JAK1(12), JAK3(13), MAP4K1(4), MAPK1(3), MAPK3(1), PDK1(3), PIK3CA(72), PIK3CD(11), PIK3R1(11), PPP1R13B(11), RAF1(10), SHC1(7), SOCS1(1), SOS1(7), SOS2(19), STAT6(3) 15687672 256 115 207 50 72 85 7 37 52 3 5.25e-05 1.000 1.000 184 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(2), CD3E(2), CD3G(1), ELK1(3), FOS(1), FYN(10), GRB2(4), JUN(4), LAT(3), LCK(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PIK3CA(72), PIK3R1(11), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), PTPN7(7), RAF1(10), RASA1(17), RELA(5), SHC1(7), SOS1(7), SYT1(4), VAV1(9), ZAP70(14) 20544651 334 125 285 65 97 106 10 49 69 3 7.02e-07 1.000 1.000 185 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(2), THTPA(2), TPK1(6) 2754764 34 26 34 10 9 11 1 5 8 0 0.327 1.000 1.000 186 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(7), CYB5R3(4), GCK(4), GFPT1(4), GNE(7), GNPDA1(4), GNPDA2(6), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), PGM3(11), RENBP(2), UAP1(5) 7274408 91 59 91 24 28 27 5 16 15 0 0.0670 1.000 1.000 187 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(3), ASL(6), CPS1(22), GLS(8), GLUD1(2), GOT1(3) 3350542 44 38 44 13 14 10 2 14 4 0 0.346 1.000 1.000 188 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(6), ELK1(3), EPO(1), EPOR(3), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PLCG1(19), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14) 9231320 111 61 105 28 30 32 3 22 22 2 0.0870 1.000 1.000 189 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(5), GSS(3), IL8(2), NFKB1(7), NOX1(6), RELA(5), TNF(3), XDH(14) 4262484 46 31 46 14 7 16 2 11 10 0 0.383 1.000 1.000 190 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(1) 3747289 40 26 39 13 13 12 3 7 5 0 0.351 1.000 1.000 191 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7) 5387439 67 43 63 20 22 17 4 15 9 0 0.281 1.000 1.000 192 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(3), ALAS2(12), CPOX(2), FECH(6), HMBS(3), PPOX(5), UROD(1), UROS(4) 3258406 40 34 40 10 8 12 2 10 8 0 0.304 1.000 1.000 193 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(8), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(3), LMNA(6), LMNB1(4), LMNB2(6), PRF1(8) 8276069 99 61 93 25 23 20 8 18 30 0 0.328 1.000 1.000 194 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(3), AKT2(8), AKT3(6), BAD(3), BTK(4), CDKN2A(13), DAPP1(1), GRB2(4), GSK3A(3), GSK3B(5), IARS(10), IGFBP1(9), INPP5D(4), PDK1(3), PIK3CA(72), PPP1R13B(11), PTEN(29), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SOS1(7), SOS2(19), TEC(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 15455685 267 126 217 59 56 89 7 48 60 7 0.00369 1.000 1.000 195 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6) 3390971 45 37 44 13 20 11 1 6 7 0 0.353 1.000 1.000 196 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(6), ENO1(3), GPI(5), HK1(16), PFKL(5), PGK1(4), PKLR(7), TPI1(1) 3978561 47 37 47 15 16 14 2 11 4 0 0.263 1.000 1.000 197 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(3), BCL2(3), CBL(3), CFLAR(1), CRKL(1), E2F1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), IRS1(24), JAK1(12), JAK3(13), MAPK1(3), MAPK3(1), MYC(5), NMI(1), PIK3CA(72), PIK3R1(11), PTPN6(4), RAF1(10), RPS6KB1(5), SHC1(7), SOCS1(1), SOCS3(3), SOS1(7), STAT5A(3), STAT5B(14), SYK(7) 15503837 236 104 188 49 51 92 6 37 48 2 0.000307 1.000 1.000 198 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(8), IFNAR2(7), IFNB1(3), JAK1(12), STAT1(10), STAT2(10), TYK2(8) 4649991 59 41 54 19 13 15 1 10 20 0 0.660 1.000 1.000 199 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3) 10717969 133 69 130 30 36 37 4 31 23 2 0.0194 1.000 1.000 200 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(7), GALNT2(5), GALNT3(4), GALNT4(5), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), WBSCR17(25) 6199575 83 57 80 24 33 14 5 15 15 1 0.346 1.000 1.000 201 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(16), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CNDP1(6), DDC(12), HAL(4), HARS(9), HDC(8), HNMT(2), MAOA(2), MAOB(3), PRPS1(3), PRPS2(3) 10481296 157 72 137 39 41 35 4 27 48 2 0.174 1.000 1.000 202 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), EGF(9), EGFR(15), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), PIK3CA(72), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3) 16110103 256 115 209 53 62 93 10 39 50 2 6.35e-05 1.000 1.000 203 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(5), GOSR1(2), GOSR2(2), SEC22B(1), SNAP25(2), SNAP29(1), STX10(3), STX11(7), STX12(2), STX16(8), STX17(2), STX18(2), STX19(3), STX2(6), STX3(2), STX4(4), STX5(1), STX6(7), STX7(2), STX8(5), TSNARE1(7), USE1(3), VAMP2(2), VAMP4(1), VAMP5(1), VAMP7(5), VTI1A(3), VTI1B(3), YKT6(1) 7168770 95 54 91 23 35 23 2 16 18 1 0.0940 1.000 1.000 204 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(6), ASPH(6), COPS5(3), CREB1(3), EDN1(3), EP300(21), EPO(1), HIF1A(7), JUN(4), LDHA(3), NOS3(10), P4HB(3), VHL(2) 7285971 72 46 68 19 17 17 5 13 19 1 0.238 1.000 1.000 205 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(6), PSMC3(8), PSMD1(6), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(14), PSMD6(2) 6859759 78 46 77 18 22 23 5 15 13 0 0.0755 1.000 1.000 206 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(6) 7719621 82 52 77 20 20 20 2 20 20 0 0.182 1.000 1.000 207 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(6), CYSLTR2(1), GPR109B(3), GPR161(12), GPR171(2), GPR18(2), GPR39(9), GPR45(12), GPR65(2), GPR68(3), GPR75(5), GPR81(3) 4226763 60 42 55 21 24 8 4 10 13 1 0.494 1.000 1.000 208 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), MTHFR(9), PRDX6(2), SHMT1(4), SHMT2(9), TPO(24) 4968930 81 60 78 23 28 10 4 18 19 2 0.315 1.000 1.000 209 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), CD4(15), FYN(10), HLA-DRA(8), LCK(4), PTPRC(19), ZAP70(14) 3878321 73 48 62 25 19 21 1 16 16 0 0.652 1.000 1.000 210 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(4), NFKB1(7), NFKBIA(1), PLCB1(18), PRKCA(5), RELA(5) 3539135 40 33 39 14 11 8 0 10 11 0 0.642 1.000 1.000 211 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), ARHGAP5(18), BAD(3), BCAR1(8), BCL2(3), BIRC2(3), BIRC3(6), BRAF(16), CAPN2(8), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(6), COL11A1(35), COL11A2(16), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), COMP(3), CRKL(1), CTNNB1(22), DIAPH1(11), DOCK1(17), EGF(9), EGFR(15), ELK1(3), ERBB2(15), FARP2(4), FIGF(4), FLNA(26), FLNB(32), FLNC(26), FLT1(16), FN1(31), FYN(10), GRB2(4), GRLF1(15), GSK3B(5), HGF(15), IBSP(2), IGF1(4), IGF1R(16), ILK(8), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), JUN(4), KDR(13), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), MAP2K1(5), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MET(8), MYL2(8), MYL7(1), MYL9(2), MYLK(32), MYLK2(4), MYLPF(1), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PARVA(2), PARVB(4), PARVG(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(15), PDGFRB(14), PDPK1(2), PGF(2), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PRKCA(5), PRKCG(17), PTEN(29), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF1(10), RELN(47), RHOA(17), ROCK1(18), ROCK2(12), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SPP1(4), SRC(3), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TLN1(22), TLN2(27), TNC(23), TNN(22), TNR(22), TNXB(44), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCL(6), VEGFB(1), VEGFC(9), VTN(8), VWF(28), ZYX(7) 159326112 2234 253 2084 783 685 549 77 467 424 32 0.238 1.000 1.000 212 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(13), ACVR1C(5), AKT1(3), AKT2(8), AKT3(6), ARRB1(3), ARRB2(1), ATF2(3), ATF4(2), BDNF(8), BRAF(16), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1F(11), CACNA1G(23), CACNA1H(26), CACNA1I(17), CACNA1S(18), CACNA2D1(10), CACNA2D2(9), CACNA2D3(17), CACNA2D4(9), CACNB1(4), CACNB2(15), CACNB3(2), CACNB4(6), CACNG1(6), CACNG2(2), CACNG3(5), CACNG4(3), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(3), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CHUK(4), CRKL(1), DAXX(10), DDIT3(4), DUSP1(2), DUSP10(8), DUSP14(3), DUSP16(9), DUSP2(2), DUSP3(1), DUSP4(1), DUSP5(8), DUSP6(3), DUSP8(1), DUSP9(5), ECSIT(4), EGF(9), EGFR(15), ELK1(3), ELK4(1), FAS(3), FASLG(3), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF13(12), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(3), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(7), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FLNA(26), FLNB(32), FLNC(26), FOS(1), GADD45B(1), GNA12(1), GNG12(11), GRB2(4), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), JUN(4), JUND(2), KRAS(28), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(24), MAP3K1(11), MAP3K10(8), MAP3K12(15), MAP3K13(9), MAP3K14(5), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP4K1(4), MAP4K2(7), MAP4K3(4), MAP4K4(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAPT(7), MAX(3), MEF2C(4), MKNK1(3), MKNK2(7), MOS(11), MRAS(2), MYC(5), NF1(29), NFATC2(17), NFATC4(16), NFKB1(7), NFKB2(7), NLK(13), NR4A1(4), NRAS(4), NTF3(5), NTRK1(10), NTRK2(13), PAK1(5), PAK2(7), PDGFA(2), PDGFB(4), PDGFRA(15), PDGFRB(14), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PPM1A(4), PPM1B(10), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PPP5C(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTPN5(6), PTPN7(7), PTPRR(12), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF2(14), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(8), RASGRP3(5), RASGRP4(4), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KA6(15), RRAS(1), RRAS2(3), SOS1(7), SOS2(19), SRF(2), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(22), TAOK3(11), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF1A(6), TP53(142), TRAF2(4), TRAF6(6), ZAK(8) 122390745 1885 252 1712 528 621 435 68 325 415 21 1.67e-07 1.000 1.000 213 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(43), APC2(15), AXIN1(9), AXIN2(15), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(19), CREBBP(40), CSNK1A1(3), CSNK1A1L(6), CSNK1E(8), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTBP1(3), CTBP2(8), CTNNB1(22), CTNNBIP1(1), CUL1(22), CXXC4(2), DAAM1(11), DAAM2(13), DKK1(9), DKK2(5), DKK4(3), DVL1(7), DVL2(6), DVL3(12), EP300(21), FBXW11(10), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LEF1(8), LRP5(22), LRP6(7), MAP3K7(10), MAPK10(5), MAPK8(6), MAPK9(3), MMP7(2), MYC(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKD1(10), NKD2(1), NLK(13), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PORCN(5), PPARD(8), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRICKLE1(16), PRICKLE2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PSEN1(3), RAC2(2), RAC3(4), RBX1(1), RHOA(17), ROCK1(18), ROCK2(12), RUVBL1(9), SENP2(4), SFRP1(4), SFRP2(6), SFRP4(6), SFRP5(1), SIAH1(2), SMAD2(9), SMAD3(5), SMAD4(26), SOX17(11), TBL1X(6), TBL1XR1(5), TBL1Y(1), TCF7(9), TCF7L1(5), TCF7L2(11), TP53(142), VANGL1(2), VANGL2(9), WIF1(2), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT16(15), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4) 69241949 1250 249 1119 314 413 287 31 212 284 23 8.97e-09 1.000 1.000 214 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY7(15), ADCY8(31), ADCY9(13), ADORA2A(1), ADORA2B(1), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), ATP2A1(16), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), ATP2B4(8), AVPR1A(14), AVPR1B(3), BDKRB1(2), BDKRB2(4), BST1(3), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1F(11), CACNA1G(23), CACNA1H(26), CACNA1I(17), CACNA1S(18), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CCKAR(5), CCKBR(9), CD38(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM5(2), CHRNA7(4), CYSLTR1(6), CYSLTR2(1), DRD1(3), EDNRA(4), EDNRB(29), EGFR(15), ERBB2(15), ERBB3(37), ERBB4(47), F2R(3), GNA11(6), GNA14(4), GNA15(3), GNAL(3), GNAQ(4), GNAS(27), GRIN1(8), GRIN2A(16), GRIN2C(6), GRIN2D(6), GRM1(31), GRM5(26), GRPR(7), HRH1(5), HRH2(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), LHCGR(11), LTB4R2(4), MYLK(32), MYLK2(4), NOS1(28), NOS3(10), NTSR1(7), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), PDE1A(7), PDE1B(6), PDE1C(11), PDGFRA(15), PDGFRB(14), PHKA1(10), PHKA2(10), PHKB(7), PHKG1(2), PHKG2(12), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PPID(3), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTAFR(5), PTGER3(5), PTGFR(5), PTK2B(16), RYR1(61), RYR2(82), RYR3(69), SLC25A4(2), SLC25A5(3), SLC25A6(5), SLC8A1(15), SLC8A2(13), SLC8A3(9), SPHK1(6), SPHK2(3), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), TNNC1(3), TRHR(5), TRPC1(8), VDAC1(3), VDAC2(1), VDAC3(3) 115508508 1865 243 1766 637 695 431 80 367 280 12 0.0116 1.000 1.000 215 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(7), ATM(38), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDAN1(12), CDC14A(18), CDC14B(4), CDC20(5), CDC25A(6), CDC25B(4), CDC25C(13), CDC6(8), CDC7(4), CDH1(30), CDK2(3), CDKN1A(3), CDKN2A(13), CHEK1(4), CHEK2(8), DTX4(7), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), EP300(21), ESPL1(15), GSK3B(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(11), HDAC6(7), HDAC8(3), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MPEG1(10), MPL(5), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(9), PRKDC(40), PTPRA(11), PTTG1(1), PTTG2(3), RB1(13), RBL1(11), SKP2(5), SMAD4(26), TBC1D8(9), TFDP1(5), TGFB1(3), TP53(142), WEE1(4) 47163803 764 242 666 175 200 177 28 158 187 14 2.04e-05 1.000 1.000 216 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(7), ANAPC1(12), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(3), ANAPC7(6), ATM(38), ATR(18), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC14A(18), CDC14B(4), CDC16(7), CDC20(5), CDC23(6), CDC25A(6), CDC25B(4), CDC25C(13), CDC26(1), CDC27(3), CDC6(8), CDC7(4), CDK2(3), CDK6(4), CDKN1A(3), CDKN2A(13), CDKN2D(3), CHEK1(4), CHEK2(8), CREBBP(40), CUL1(22), DBF4(7), E2F1(3), E2F2(4), E2F3(3), EP300(21), ESPL1(15), FZR1(7), GADD45B(1), GSK3B(5), HDAC1(5), HDAC2(2), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(9), PRKDC(40), PTTG1(1), PTTG2(3), RB1(13), RBL1(11), RBL2(8), RBX1(1), SFN(1), SKP2(5), SMAD2(9), SMAD3(5), SMAD4(26), SMC1A(7), SMC1B(8), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TP53(142), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 58270329 845 235 748 206 228 199 26 171 207 14 0.000254 1.000 1.000 217 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(6), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), APC(43), APC2(15), ARAF(12), ARHGEF1(11), ARHGEF12(14), ARHGEF4(8), ARHGEF6(13), ARHGEF7(8), ARPC1A(3), ARPC2(3), ARPC4(2), ARPC5L(1), BAIAP2(5), BCAR1(8), BDKRB1(2), BDKRB2(4), BRAF(16), CD14(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CRKL(1), CSK(7), CYFIP1(12), CYFIP2(15), DIAPH1(11), DIAPH2(7), DIAPH3(13), DOCK1(17), EGF(9), EGFR(15), EZR(6), F2(9), F2R(3), FGD1(12), FGD3(12), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF13(12), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(3), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(7), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FN1(31), GIT1(3), GNA12(1), GNA13(5), GNG12(11), GRLF1(15), GSN(11), IQGAP1(14), IQGAP2(10), IQGAP3(13), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(13), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), KRAS(28), LIMK1(4), LIMK2(2), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(11), MRAS(2), MSN(9), MYH10(36), MYH14(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLK(32), MYLK2(4), MYLPF(1), NCKAP1(9), NCKAP1L(14), NRAS(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDGFA(2), PDGFB(4), PDGFRA(15), PDGFRB(14), PFN2(2), PFN3(3), PFN4(1), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R12B(15), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RDX(7), RHOA(17), ROCK1(18), ROCK2(12), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(10), SOS1(7), SOS2(19), SSH1(9), SSH2(22), SSH3(8), TIAM1(32), TIAM2(23), TMSL3(1), VAV1(9), VAV2(12), VAV3(10), VCL(6), WAS(3), WASF1(5), WASF2(5), WASL(3) 118510238 1702 229 1561 561 541 430 59 336 312 24 0.0683 1.000 1.000 218 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(7), ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA2A(7), ADRA2B(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), C5AR1(5), CALCR(6), CALCRL(8), CCKAR(5), CCKBR(9), CGA(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CNR1(11), CRHR1(11), CRHR2(4), CTSG(3), CYSLTR1(6), CYSLTR2(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), EDNRB(29), F2(9), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), FSHB(1), FSHR(20), GABBR1(15), GABBR2(11), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GABRB1(8), GABRB2(5), GABRB3(11), GABRD(7), GABRE(7), GABRG1(4), GABRG2(13), GABRG3(6), GABRP(4), GABRQ(12), GABRR1(6), GABRR2(7), GALR1(6), GALR2(10), GALR3(2), GH1(2), GH2(1), GHR(6), GHRHR(4), GHSR(9), GIPR(3), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(5), GLRA3(6), GLRB(8), GNRHR(4), GPR156(5), GPR35(4), GPR50(11), GPR63(2), GPR83(5), GRIA1(21), GRIA2(23), GRIA3(8), GRIA4(10), GRID1(24), GRID2(16), GRIK1(11), GRIK2(18), GRIK3(16), GRIK4(14), GRIK5(10), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), GRIN3A(18), GRIN3B(6), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM6(10), GRM7(20), GRM8(22), GRPR(7), GZMA(2), HCRTR1(6), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HRH4(3), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LEP(2), LEPR(13), LHB(1), LHCGR(11), LTB4R(2), LTB4R2(4), MAS1(2), MC2R(2), MC3R(9), MC4R(5), MC5R(5), MCHR1(6), MCHR2(4), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPBWR1(13), NPBWR2(8), NPFFR1(1), NPFFR2(10), NPY1R(4), NPY2R(6), NPY5R(4), NR3C1(6), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(4), P2RY14(4), P2RY2(5), P2RY4(5), P2RY6(8), P2RY8(7), PARD3(11), PPYR1(7), PRL(1), PRLHR(7), PRLR(4), PRSS1(1), PRSS3(3), PTAFR(5), PTGDR(7), PTGER2(5), PTGER3(5), PTGER4(8), PTGFR(5), PTH2R(8), RXFP1(8), RXFP2(10), SCTR(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SSTR5(4), TAAR1(4), TAAR2(3), TAAR5(6), TAAR6(7), TAAR9(1), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), THRA(6), THRB(9), TRHR(5), TRPV1(8), TSHB(3), TSHR(10), TSPO(1), UTS2R(3), VIPR1(3), VIPR2(3) 95210782 1676 227 1617 567 614 373 72 411 202 4 0.00103 1.000 1.000 219 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(8), ACTG1(1), CHAD(6), COL11A1(35), COL11A2(16), COL17A1(9), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), COMP(3), DES(1), DSC1(2), DSC2(12), DSC3(4), DSG1(5), DSG2(6), DSG3(10), DSG4(8), FN1(31), GJA1(11), GJA10(3), GJA3(2), GJA4(4), GJA5(8), GJA8(8), GJA9(3), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(2), GJC1(3), GJC2(3), GJD2(5), GJD4(6), IBSP(2), INA(7), ITGA6(6), ITGB4(18), KRT1(6), KRT10(6), KRT12(3), KRT13(9), KRT14(2), KRT15(3), KRT16(8), KRT17(5), KRT18(2), KRT19(1), KRT2(10), KRT20(4), KRT23(11), KRT24(6), KRT25(7), KRT27(8), KRT28(10), KRT3(8), KRT31(6), KRT32(7), KRT33A(9), KRT33B(4), KRT34(6), KRT35(4), KRT36(6), KRT37(3), KRT38(4), KRT39(8), KRT4(7), KRT40(1), KRT5(3), KRT6A(9), KRT6B(3), KRT6C(7), KRT7(3), KRT71(2), KRT72(7), KRT73(15), KRT74(4), KRT75(6), KRT76(4), KRT77(2), KRT78(3), KRT79(5), KRT8(6), KRT81(3), KRT82(2), KRT83(3), KRT84(6), KRT85(3), KRT86(3), KRT9(1), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), LMNA(6), LMNB1(4), LMNB2(6), NES(12), PRPH(3), RELN(47), SPP1(4), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(23), TNN(22), TNR(22), TNXB(44), VIM(10), VTN(8), VWF(28) 107036911 1415 219 1381 588 443 330 56 330 241 15 0.995 1.000 1.000 220 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(7), ABLIM1(12), ABLIM2(11), ABLIM3(6), ARHGEF12(14), CDC42(1), CDK5(2), CFL1(1), CFL2(1), CXCR4(1), DCC(32), DPYSL2(2), DPYSL5(10), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(4), EFNB1(1), EFNB2(3), EFNB3(7), EPHA1(13), EPHA2(25), EPHA3(22), EPHA4(17), EPHA5(28), EPHA6(27), EPHA7(6), EPHA8(13), EPHB1(23), EPHB2(12), EPHB3(12), EPHB4(9), EPHB6(14), FES(11), FYN(10), GNAI1(1), GNAI2(3), GNAI3(7), GSK3B(5), ITGB1(10), KRAS(28), L1CAM(16), LIMK1(4), LIMK2(2), LRRC4C(5), MAPK1(3), MAPK3(1), MET(8), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NGEF(6), NRAS(4), NRP1(14), NTN1(7), NTN4(2), NTNG1(19), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PLXNA1(32), PLXNA2(26), PLXNA3(19), PLXNB1(19), PLXNB2(17), PLXNB3(12), PLXNC1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PTK2(11), RAC2(2), RAC3(4), RASA1(17), RGS3(13), RHOA(17), RHOD(2), RND1(3), ROBO1(30), ROBO2(33), ROBO3(11), ROCK1(18), ROCK2(12), SEMA3A(15), SEMA3B(4), SEMA3C(7), SEMA3D(12), SEMA3E(12), SEMA3F(10), SEMA3G(5), SEMA4A(9), SEMA4B(9), SEMA4C(10), SEMA4D(15), SEMA4F(8), SEMA4G(4), SEMA5A(24), SEMA5B(20), SEMA6A(18), SEMA6B(5), SEMA6C(10), SEMA6D(20), SEMA7A(7), SLIT1(10), SLIT2(27), SLIT3(14), SRGAP1(12), SRGAP2(7), SRGAP3(13), UNC5A(10), UNC5B(10), UNC5C(16), UNC5D(16) 84503994 1326 217 1259 437 405 305 73 298 232 13 0.0937 1.000 1.000 221 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), AMOTL1(8), ASH1L(39), CASK(7), CDC42(1), CGN(13), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CSDA(5), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTTN(7), EPB41(11), EPB41L1(6), EPB41L2(9), EPB41L3(27), EXOC3(3), EXOC4(8), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), HCLS1(3), IGSF5(3), INADL(16), JAM2(2), JAM3(8), KRAS(28), LLGL1(9), LLGL2(6), MAGI1(18), MAGI2(30), MAGI3(9), MLLT4(24), MPDZ(23), MPP5(1), MRAS(2), MYH1(20), MYH10(36), MYH11(29), MYH13(24), MYH14(18), MYH15(17), MYH2(29), MYH3(27), MYH4(22), MYH6(27), MYH7(23), MYH7B(23), MYH8(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLPF(1), NRAS(4), OCLN(6), PARD3(11), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP2R3A(9), PPP2R3B(14), PPP2R4(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), PTEN(29), RAB13(2), RAB3B(3), RHOA(17), RRAS(1), RRAS2(3), SPTAN1(20), SRC(3), SYMPK(7), TJAP1(2), TJP1(21), TJP2(15), TJP3(11), VAPA(3), YES1(2), ZAK(8) 83335180 1236 216 1162 371 388 305 40 285 205 13 0.00644 1.000 1.000 222 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(10), CADM1(14), CADM3(11), CD2(3), CD22(5), CD226(2), CD274(2), CD276(6), CD28(2), CD34(4), CD4(15), CD40(3), CD40LG(5), CD58(6), CD6(9), CD80(4), CD86(6), CD8A(4), CD8B(1), CD99(1), CDH1(30), CDH15(6), CDH2(18), CDH3(10), CDH4(21), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CNTN1(19), CNTN2(10), CNTNAP1(18), CNTNAP2(40), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-A(16), HLA-B(14), HLA-C(13), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(12), HLA-G(5), ICAM1(2), ICAM2(3), ICAM3(1), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(6), ITGA8(6), ITGA9(8), ITGAL(16), ITGAM(9), ITGAV(13), ITGB1(10), ITGB2(6), ITGB7(6), ITGB8(14), JAM2(2), JAM3(8), L1CAM(16), MAG(14), MPZ(2), MPZL1(2), NCAM1(4), NCAM2(24), NEGR1(7), NEO1(14), NFASC(18), NLGN1(16), NLGN2(10), NLGN3(13), NRCAM(11), NRXN1(43), NRXN2(28), NRXN3(28), OCLN(6), PDCD1(2), PDCD1LG2(1), PTPRC(19), PTPRF(18), PTPRM(28), PVR(3), PVRL1(1), PVRL2(5), PVRL3(6), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SELE(5), SELL(4), SELP(10), SELPLG(7), SIGLEC1(18), SPN(4), VCAM1(10), VCAN(41) 63361967 1049 215 990 352 316 264 36 235 189 9 0.0369 1.000 1.000 223 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(19), ATP1B1(2), ATP1B2(3), ATP1B3(3), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1S(18), CACNB1(4), CACNB3(2), CALM1(2), CALM2(2), CALR(5), CAMK1(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), GJA1(11), GJA4(4), GJA5(8), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAZ(18), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG12(11), GNG13(2), GNG7(4), GNGT1(3), GRK4(4), GRK5(1), GRK6(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNB1(12), KCNJ3(16), KCNJ5(5), MIB1(4), NME7(1), PKIA(2), PKIG(2), PLCB3(12), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RYR1(61), RYR2(82), RYR3(69), SFN(1), SLC8A1(15), SLC8A3(9), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2) 80433953 1250 214 1204 451 458 295 55 246 185 11 0.131 1.000 1.000 224 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(15), CD36(2), CD44(5), CHAD(6), COL11A1(35), COL11A2(16), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), DAG1(13), FN1(31), FNDC1(15), FNDC3A(8), FNDC4(2), FNDC5(2), GP5(7), GP6(3), GP9(3), HMMR(7), HSPG2(35), IBSP(2), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), RELN(47), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SPP1(4), SV2A(13), SV2B(5), SV2C(9), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(23), TNN(22), TNR(22), TNXB(44), VTN(8), VWF(28) 96226801 1273 212 1227 501 403 276 45 300 231 18 0.935 1.000 1.000 225 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(38), CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC25A(6), CDK2(3), CDKN1A(3), CDKN2A(13), CDKN2D(3), CREB3(7), CREB3L1(4), CREB3L3(4), CREB3L4(2), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), GBA2(4), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MNAT1(3), MYC(5), MYT1(19), NACA(2), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(4), POLE(24), POLE2(4), PRIM1(2), RB1(13), RBL1(11), RPA1(2), RPA2(2), RPA3(2), TFDP1(5), TFDP2(4), TNXB(44), TP53(142), WEE1(4) 33123668 500 209 429 119 147 112 18 91 121 11 0.000109 1.000 1.000 226 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(4), BAX(6), BFAR(5), BTK(4), CAD(18), CASP10(6), CASP3(2), CASP8(18), CASP8AP2(10), CD7(5), CSNK1A1(3), DAXX(10), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(15), EPHB2(12), FADD(1), FAF1(8), FAIM2(1), IL1A(2), IL8(2), MAP2K4(9), MAP2K7(24), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MET(8), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), NR0B2(3), PFN2(2), PTPN13(24), RALBP1(8), RIPK1(2), ROCK1(18), SMPD1(8), TP53(142), TPX2(6), TRAF2(4), TUFM(3) 31189556 506 198 433 122 144 110 13 90 138 11 0.000719 1.000 1.000 227 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(6), ACTN2(23), ACTN3(4), ACTN4(11), DES(1), DMD(62), FAM48A(10), MYBPC1(7), MYBPC2(10), MYBPC3(6), MYH3(27), MYH6(27), MYH7(23), MYH8(18), MYL1(1), MYL2(8), MYL3(3), MYL9(2), MYOM1(12), NEB(63), TMOD1(4), TNNI1(2), TNNI2(6), TNNT1(5), TNNT2(2), TNNT3(2), TPM1(4), TPM3(3), TPM4(3), TTN(512), VIM(10) 58405619 880 195 862 262 225 233 50 279 77 16 0.0102 1.000 1.000 228 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCBP2(2), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CCRL1(5), CCRL2(1), CHML(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CMKLR1(4), CNR1(11), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), EDNRB(29), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), FSHR(20), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GPR17(5), GPR173(5), GPR174(3), GPR27(5), GPR3(4), GPR35(4), GPR37(10), GPR37L1(5), GPR4(3), GPR50(11), GPR6(11), GPR63(2), GPR77(5), GPR83(5), GPR85(4), GPR87(5), GRPR(7), HCRTR1(6), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LHCGR(11), LTB4R(2), MAS1(2), MC3R(9), MC4R(5), MC5R(5), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPN1SW(1), OPN3(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OR10A5(5), OR11A1(5), OR12D3(4), OR1C1(5), OR1F1(4), OR1Q1(5), OR2H1(2), OR5V1(7), OR7C1(6), OR8B8(5), OXTR(7), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(4), P2RY14(4), P2RY2(5), P2RY6(8), PPYR1(7), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), RGR(2), RHO(7), RRH(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SUCNR1(4), TBXA2R(8), TRHR(5) 52281399 897 194 862 327 330 216 36 196 115 4 0.0376 1.000 1.000 229 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(5), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), ACVR1B(13), ACVR1C(5), BAIAP2(5), CDC42(1), CDH1(30), CREBBP(40), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), EGFR(15), EP300(21), ERBB2(15), FARP2(4), FER(13), FGFR1(13), FYN(10), IGF1R(16), INSR(14), IQGAP1(14), LEF1(8), LMO7(14), MAP3K7(10), MAPK1(3), MAPK3(1), MET(8), MLLT4(24), NLK(13), PARD3(11), PTPN1(3), PTPN6(4), PTPRB(22), PTPRF(18), PTPRJ(27), PTPRM(28), PVRL1(1), PVRL2(5), PVRL3(6), PVRL4(7), RAC2(2), RAC3(4), RHOA(17), SMAD2(9), SMAD3(5), SMAD4(26), SNAI1(3), SNAI2(11), SORBS1(9), SRC(3), SSX2IP(9), TCF7(9), TCF7L1(5), TCF7L2(11), TGFBR1(4), TGFBR2(14), TJP1(21), VCL(6), WAS(3), WASF1(5), WASF2(5), WASF3(13), WASL(3), YES1(2) 51429022 804 194 751 231 217 220 26 156 174 11 0.00581 1.000 1.000 230 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(13), ACVR2A(8), ACVR2B(5), AMHR2(4), BMP2(5), BMP7(7), BMPR1A(5), BMPR1B(7), BMPR2(16), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(2), CCL2(1), CCL20(2), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL3(1), CCL5(2), CCL7(1), CCL8(2), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CD27(2), CD40(3), CD40LG(5), CD70(2), CLCF1(2), CNTF(3), CNTFR(3), CSF1(2), CSF1R(15), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), CX3CL1(7), CX3CR1(3), CXCL10(1), CXCL16(3), CXCL2(2), CXCL9(2), CXCR3(1), CXCR4(1), CXCR6(2), EDA(1), EDA2R(3), EDAR(8), EGF(9), EGFR(15), EPO(1), EPOR(3), FAS(3), FASLG(3), FLT1(16), FLT3(10), FLT3LG(1), FLT4(24), GDF5(11), GH1(2), GH2(1), GHR(6), HGF(15), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL13(2), IL13RA1(4), IL15RA(3), IL17B(4), IL17RA(7), IL17RB(6), IL18(1), IL18R1(3), IL18RAP(2), IL19(1), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL1RAP(7), IL20(1), IL20RA(8), IL21(4), IL21R(10), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL28A(1), IL28B(5), IL28RA(2), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL8(2), IL9R(3), INHBA(12), INHBB(10), INHBC(6), INHBE(2), KDR(13), KIT(12), KITLG(3), LEP(2), LEPR(13), LIF(2), LIFR(13), LTA(4), LTBR(2), MET(8), MPL(5), NGFR(4), OSM(5), OSMR(8), PDGFB(4), PDGFC(7), PDGFRA(15), PDGFRB(14), PF4V1(1), PLEKHO2(3), PRL(1), PRLR(4), RELT(6), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(3), TNFRSF13B(5), TNFRSF13C(4), TNFRSF14(1), TNFRSF17(1), TNFRSF19(9), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFRSF4(3), TNFRSF8(4), TNFRSF9(11), TNFSF10(5), TNFSF11(4), TNFSF13B(4), TNFSF14(3), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(24), TSLP(3), VEGFB(1), VEGFC(9), XCL1(1), XCR1(4) 76037446 963 193 925 342 279 239 40 210 187 8 0.386 1.000 1.000 231 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(6), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADM(2), ARRB1(3), ARRB2(1), ATF2(3), ATF3(1), ATF4(2), ATF5(3), ATP2A2(5), ATP2A3(6), CACNB3(2), CALCA(2), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CNN1(3), CNN2(1), CORIN(13), CREB3(7), CRHR1(11), DGKZ(8), ETS2(4), FOS(1), GABPA(2), GABPB2(3), GBA2(4), GJA1(11), GNAQ(4), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG12(11), GNG13(2), GNG7(4), GNGT1(3), GRK4(4), GRK5(1), GRK6(4), GUCA2A(1), GUCA2B(1), GUCY1A3(15), IGFBP1(9), IGFBP2(5), IGFBP3(6), IGFBP4(1), IGFBP6(1), IL1B(3), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), MAFF(1), MIB1(4), MYL2(8), MYLK2(4), NFKB1(7), NOS1(28), NOS3(10), OXT(1), OXTR(7), PDE4B(5), PDE4D(4), PKIA(2), PKIG(2), PLCB3(12), PLCD1(4), PLCG1(19), PLCG2(15), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), RAMP2(2), RAMP3(3), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RLN1(3), RYR1(61), RYR2(82), RYR3(69), SFN(1), SLC8A1(15), SP1(6), TNXB(44), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2) 74273298 1054 192 1014 385 369 230 45 234 167 9 0.368 1.000 1.000 232 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(7), ABL2(12), AKT1(3), AKT2(8), AKT3(6), ARAF(12), BAD(3), BRAF(16), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CBL(3), CBLB(3), CBLC(5), CDKN1A(3), CRKL(1), EGF(9), EGFR(15), EIF4EBP1(2), ELK1(3), ERBB2(15), ERBB3(37), ERBB4(47), EREG(2), GAB1(3), GRB2(4), GSK3B(5), HBEGF(1), JUN(4), KRAS(28), MAP2K1(5), MAP2K2(3), MAP2K4(9), MAP2K7(24), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MYC(5), NCK1(6), NCK2(5), NRAS(4), NRG1(14), NRG2(8), NRG3(17), NRG4(2), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), RAF1(10), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SRC(3), STAT5A(3), STAT5B(14), TGFA(2) 44187482 753 191 646 196 222 219 32 141 134 5 3.87e-05 1.000 1.000 233 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(23), ACACB(34), AKT1(3), AKT2(8), AKT3(6), ARAF(12), BAD(3), BRAF(16), CALM1(2), CALM2(2), CALML3(1), CBL(3), CBLB(3), CBLC(5), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(11), FASN(19), FBP1(4), FBP2(5), FLOT1(4), FLOT2(5), FOXO1(4), G6PC2(1), GCK(4), GRB2(4), GSK3B(5), GYS1(6), GYS2(6), IKBKB(7), INPP5D(4), INSR(14), IRS1(24), IRS2(6), IRS4(27), KRAS(28), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MKNK1(3), MKNK2(7), NRAS(4), PCK1(11), PCK2(9), PDE3A(13), PDE3B(20), PDPK1(2), PFKL(5), PFKM(3), PFKP(15), PHKA1(10), PHKA2(10), PHKB(7), PHKG1(2), PHKG2(12), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PKLR(7), PKM2(6), PPARGC1A(10), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R3A(28), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCI(8), PRKCZ(1), PRKX(5), PTPN1(3), PTPRF(18), PYGB(10), PYGL(8), PYGM(14), RAF1(10), RAPGEF1(10), RHEB(1), RHOQ(5), RPS6(1), RPS6KB1(5), RPS6KB2(4), SH2B2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(9), SOS1(7), SOS2(19), SREBF1(12), TRIP10(9), TSC1(7), TSC2(12) 68684580 1000 191 891 311 300 270 31 174 216 9 0.0236 1.000 1.000 234 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(9), EGF(9), EGFR(15), GJA1(11), GJD2(5), GNA11(6), GNAI1(1), GNAI2(3), GNAI3(7), GNAQ(4), GNAS(27), GRB2(4), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), HTR2A(6), HTR2B(5), HTR2C(6), ITPR1(24), ITPR2(30), ITPR3(36), KRAS(28), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(11), NPR2(8), NRAS(4), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(15), PDGFRB(14), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKG1(9), PRKG2(13), PRKX(5), RAF1(10), SOS1(7), SOS2(19), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2) 56741078 880 188 834 311 287 230 34 200 124 5 0.254 1.000 1.000 235 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(8), AKT3(6), CBL(3), CBLB(3), CBLC(5), CCND1(1), CCND2(3), CCND3(2), CISH(3), CLCF1(2), CNTF(3), CNTFR(3), CREBBP(40), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), EP300(21), EPO(1), EPOR(3), GH1(2), GH2(1), GHR(6), GRB2(4), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL13(2), IL13RA1(4), IL13RA2(6), IL15RA(3), IL19(1), IL20(1), IL20RA(8), IL21(4), IL21R(10), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL28A(1), IL28B(5), IL28RA(2), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(3), IRF9(6), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), LIF(2), LIFR(13), MPL(5), MYC(5), OSM(5), OSMR(8), PIAS1(12), PIAS2(12), PIAS3(7), PIAS4(7), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIM1(2), PRL(1), PRLR(4), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(6), SOCS7(3), SOS1(7), SOS2(19), SPRED1(13), SPRED2(7), SPRY1(3), SPRY3(6), SPRY4(5), STAM(7), STAM2(5), STAT1(10), STAT2(10), STAT3(7), STAT4(6), STAT5A(3), STAT5B(14), STAT6(3), TPO(24), TSLP(3), TYK2(8) 62345505 849 186 766 243 218 241 34 171 179 6 0.00683 1.000 1.000 236 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), AKAP1(3), AKAP10(3), AKAP11(16), AKAP12(18), AKAP3(12), AKAP4(11), AKAP5(2), AKAP6(23), AKAP7(3), AKAP8(10), AKAP9(39), ARHGEF1(11), CALM1(2), CALM2(2), CHMP1B(1), GNA11(6), GNA12(1), GNA13(5), GNA14(4), GNA15(3), GNAI2(3), GNAI3(7), GNAL(3), GNAO1(1), GNAQ(4), GNAZ(18), GNB1(1), GNB2(3), GNB3(1), GNB5(1), GNG12(11), GNG13(2), GNG7(4), GNGT1(3), GNGT2(2), ITPR1(24), KCNJ3(16), KRAS(28), NRAS(4), PDE1A(7), PDE1B(6), PDE1C(11), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PLCB3(12), PPP3CA(10), PPP3CC(5), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), PRKD1(20), PRKD3(5), RHOA(17), RRAS(1), SLC9A1(10), USP5(6) 50175545 712 183 649 235 191 203 23 155 132 8 0.134 1.000 1.000 237 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), ARHGAP5(18), BCAR1(8), CD99(1), CDC42(1), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), CXCR4(1), CYBB(8), ESAM(5), EZR(6), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), GRLF1(15), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), ITK(6), JAM2(2), JAM3(8), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(24), MMP2(6), MMP9(17), MSN(9), MYL2(8), MYL7(1), MYL9(2), MYLPF(1), NCF1(3), NCF2(4), NCF4(1), NOX1(6), NOX3(7), OCLN(6), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAC2(2), RAP1A(2), RAP1B(6), RAPGEF3(2), RAPGEF4(8), RASSF5(4), RHOA(17), RHOH(2), ROCK1(18), ROCK2(12), SIPA1(4), THY1(1), TXK(2), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCAM1(10), VCL(6) 53301228 838 182 755 264 248 221 33 150 174 12 0.0566 1.000 1.000 238 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADK(4), ADSL(5), ADSS(5), ADSSL1(8), AK1(1), AK5(4), AK7(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), GART(9), GDA(4), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), IMPDH2(4), ITPA(1), NME6(3), NME7(1), NPR1(11), NPR2(8), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NT5M(5), NUDT2(4), NUDT9(2), PAICS(1), PAPSS1(6), PAPSS2(5), PDE10A(17), PDE11A(8), PDE1A(7), PDE1C(11), PDE2A(14), PDE3B(20), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6D(1), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PDE9A(7), PFAS(9), PKLR(7), PKM2(6), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PPAT(5), PRIM1(2), PRIM2(4), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), XDH(14), ZNRD1(1) 69999995 859 181 829 298 267 218 32 180 157 5 0.420 1.000 1.000 239 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(8), AKT3(6), BCL10(2), CARD11(20), CBL(3), CBLB(3), CBLC(5), CD247(3), CD28(2), CD3E(2), CD3G(1), CD4(15), CD40LG(5), CD8A(4), CD8B(1), CDC42(1), CHUK(4), CTLA4(3), FOS(1), FYN(10), GRAP2(4), GRB2(4), ICOS(2), IFNG(2), IKBKB(7), IL10(2), IL4(1), ITK(6), JUN(4), KRAS(28), LAT(3), LCK(4), LCP2(7), MALT1(4), MAP3K14(5), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDCD1(2), PDK1(3), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKCQ(10), PTPN6(4), PTPRC(19), RASGRP1(8), RHOA(17), SOS1(7), SOS2(19), TEC(4), TNF(3), VAV1(9), VAV2(12), VAV3(10), ZAP70(14) 43556297 670 180 576 179 186 207 23 128 123 3 0.000293 1.000 1.000 240 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(12), BRAF(16), C7orf16(3), CACNA1A(24), CRHR1(11), GNA11(6), GNA12(1), GNA13(5), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(27), GNAZ(18), GRIA1(21), GRIA2(23), GRIA3(8), GRID2(16), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), IGF1(4), IGF1R(16), ITPR1(24), ITPR2(30), ITPR3(36), KRAS(28), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(28), NOS3(10), NPR1(11), NPR2(8), NRAS(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PRKCA(5), PRKCG(17), PRKG1(9), PRKG2(13), RAF1(10), RYR1(61) 47291736 800 180 744 238 273 196 28 191 107 5 0.00539 1.000 1.000 241 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(7), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGEF6(13), ARHGEF7(8), BCAR1(8), BRAF(16), CAV1(4), CDC42(1), CDKN2A(13), CSE1L(5), DOCK1(17), EPHB2(12), FYN(10), GRB2(4), GRB7(6), GRLF1(15), ILK(8), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGB3BP(1), MAP2K4(9), MAP2K7(24), MAP3K11(10), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MRAS(2), MYLK(32), MYLK2(4), P4HB(3), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PIK3CA(72), PIK3CB(13), PKLR(7), PLCG1(19), PLCG2(15), PTEN(29), PTK2(11), RAF1(10), RHO(7), ROCK1(18), ROCK2(12), SHC1(7), SOS1(7), SOS2(19), SRC(3), TERF2IP(5), TLN1(22), TLN2(27), VASP(2), WAS(3), ZYX(7) 52467660 764 176 688 214 235 191 25 129 167 17 0.00697 1.000 1.000 242 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(2), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5D(4), INPP5E(6), INPPL1(24), ITGB1BP3(2), ITPK1(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), OCRL(9), PI4KA(15), PI4KB(5), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3C3(14), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PRKCA(5), PRKCG(17), PTEN(29), PTPMT1(1), SYNJ1(10), SYNJ2(17) 53366254 740 175 658 203 222 201 24 134 147 12 0.00131 1.000 1.000 243 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(13), ACVRL1(5), AKT1(3), AURKB(5), BMPR1A(5), BMPR2(16), BUB1(12), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(6), CDS2(2), CLK1(4), CLK2(11), CLK4(4), COL4A3BP(5), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MAP3K10(8), MOS(11), NEK1(4), NEK3(3), OCRL(9), PAK4(8), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3CA(72), PIK3CB(13), PIK3CG(21), PIM2(3), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15), PLK3(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), PRKG1(9), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KB1(5), STK11(3), TGFBR1(4), VRK1(1) 48352231 699 174 627 186 191 192 29 138 142 7 0.00253 1.000 1.000 244 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(13), ACVR1C(5), ACVR2A(8), ACVR2B(5), ACVRL1(5), AMHR2(4), BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BMPR1A(5), BMPR1B(7), BMPR2(16), CHRD(9), COMP(3), CREBBP(40), CUL1(22), DCN(8), E2F5(1), EP300(21), FST(4), GDF5(11), GDF6(15), GDF7(4), ID1(1), ID3(1), IFNG(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), LEFTY1(4), LTBP1(19), MAPK1(3), MAPK3(1), MYC(5), NOG(1), PITX2(6), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), RBL1(11), RBL2(8), RBX1(1), RHOA(17), ROCK1(18), ROCK2(12), RPS6KB1(5), RPS6KB2(4), SMAD1(4), SMAD2(9), SMAD3(5), SMAD4(26), SMAD5(2), SMAD6(5), SMAD7(5), SMAD9(8), SMURF1(5), SMURF2(5), SP1(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNF(3), ZFYVE16(11), ZFYVE9(8) 42424868 641 172 611 205 197 157 27 117 132 11 0.103 1.000 1.000 245 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ATF4(2), CACNA1C(37), CACNA1D(34), CACNA1F(11), CACNA1S(18), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CDC42(1), CGA(1), EGFR(15), ELK1(3), FSHB(1), GNA11(6), GNAQ(4), GNAS(27), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(1), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), KRAS(28), LHB(1), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP2K7(24), MAP3K1(11), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(6), MAPK9(3), MMP14(6), MMP2(6), NRAS(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLD1(19), PLD2(15), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(7), PRKX(5), PTK2B(16), RAF1(10), SOS1(7), SOS2(19), SRC(3) 54587429 807 172 761 253 284 205 28 150 134 6 0.0120 1.000 1.000 246 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(8), AKT3(6), BAD(3), CDC42(1), CDK2(3), CDKN2A(13), CREB1(3), CREB3(7), CREB5(5), EBP(1), ERBB4(47), F2RL2(3), GAB1(3), GRB2(4), GSK3A(3), GSK3B(5), IFI27(1), IGF1(4), IGFBP1(9), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), MET(8), MYC(5), NOLC1(9), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PARD3(11), PARD6A(1), PDK1(3), PIK3CA(72), PIK3CD(11), PPP1R13B(11), PREX1(16), PTEN(29), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SLC2A4(4), SOS1(7), SOS2(19), TSC1(7), TSC2(12), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 33199775 544 172 472 132 152 145 23 92 123 9 0.000205 1.000 1.000 247 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(12), BID(2), BRAF(16), CASP3(2), CD244(2), CD247(3), CD48(1), FAS(3), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(10), GRB2(4), GZMB(3), HCST(1), HLA-A(16), HLA-B(14), HLA-C(13), HLA-E(5), HLA-G(5), ICAM1(2), ICAM2(3), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), ITGAL(16), ITGB2(6), KIR2DL1(4), KIR2DL3(2), KIR2DL4(3), KIR3DL1(7), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), KRAS(28), LAT(3), LCK(4), LCP2(7), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICB(3), NCR1(3), NCR2(3), NCR3(1), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NRAS(4), PAK1(5), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRF1(8), PRKCA(5), PRKCG(17), PTK2B(16), PTPN11(6), PTPN6(4), RAC2(2), RAC3(4), RAF1(10), SH2D1A(1), SH2D1B(1), SH3BP2(5), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SYK(7), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFSF10(5), TYROBP(2), ULBP1(3), ULBP3(1), VAV1(9), VAV2(12), VAV3(10), ZAP70(14) 48704714 782 171 682 199 206 228 24 148 172 4 5.19e-06 1.000 1.000 248 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(8), AKT3(6), CASP8(18), CCL3(1), CCL5(2), CD14(2), CD40(3), CD80(4), CD86(6), CHUK(4), CXCL10(1), CXCL9(2), FADD(1), FOS(1), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IKBKB(7), IKBKE(12), IL12A(2), IL12B(2), IL1B(3), IL8(2), IRAK1(6), IRAK4(3), IRF3(3), IRF5(4), IRF7(1), JUN(4), LBP(1), LY96(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP2K7(24), MAP3K7(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MYD88(4), NFKB1(7), NFKB2(7), NFKBIA(1), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), RELA(5), RIPK1(2), SPP1(4), STAT1(10), TBK1(8), TICAM1(8), TIRAP(1), TLR1(6), TLR2(2), TLR3(6), TLR4(21), TLR5(10), TLR6(3), TLR7(5), TLR8(14), TLR9(16), TNF(3), TOLLIP(5), TRAF3(4), TRAF6(6) 38485082 554 170 490 154 142 152 23 114 120 3 0.00941 1.000 1.000 249 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(19), ADCY8(31), ARAF(12), ATF4(2), BRAF(16), CACNA1C(37), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CREBBP(40), EP300(21), GNAQ(4), GRIA1(21), GRIA2(23), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), GRM1(31), GRM5(26), ITPR1(24), ITPR2(30), ITPR3(36), KRAS(28), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(4), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R1A(1), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF3(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15) 42652017 697 169 650 218 220 192 18 146 117 4 0.0117 1.000 1.000 250 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ASIP(2), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CREB1(3), CREB3(7), CREB3L1(4), CREB3L2(4), CREB3L3(4), CREB3L4(2), CREBBP(40), CTNNB1(22), DCT(13), DVL1(7), DVL2(6), DVL3(12), EDN1(3), EDNRB(29), EP300(21), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(27), GSK3B(5), KIT(12), KITLG(3), KRAS(28), LEF1(8), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MITF(10), NRAS(4), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), POMC(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), TCF7(9), TCF7L1(5), TCF7L2(11), TYR(9), TYRP1(4), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT16(15), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4) 46773547 801 165 732 265 282 208 21 147 139 4 0.0225 1.000 1.000 251 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADK(4), ADSL(5), ADSS(5), AK1(1), AK5(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), ATP1B1(2), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(2), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), GART(9), GDA(4), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), IMPDH2(4), ITPA(1), NPR1(11), NPR2(8), NT5C(1), NT5E(2), NT5M(5), NUDT2(4), PAICS(1), PAPSS1(6), PAPSS2(5), PDE1A(7), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6B(10), PDE6C(4), PDE6G(1), PDE7B(3), PDE8A(10), PDE9A(7), PFAS(9), PKLR(7), PKM2(6), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RRM1(5), RRM2(4) 54951952 678 163 651 234 196 176 28 151 123 4 0.474 1.000 1.000 252 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(8), AKT3(6), BAD(3), CASP9(3), CDC42(1), KDR(13), KRAS(28), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NOS3(10), NRAS(4), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKCA(5), PRKCG(17), PTGS2(7), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), SH2D2A(7), SHC2(2), SPHK1(6), SPHK2(3), SRC(3) 30886220 501 158 419 114 148 156 18 91 86 2 5.78e-07 1.000 1.000 253 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(6), BCAR1(8), CAPN1(5), CAPN10(7), CAPN11(6), CAPN2(8), CAPN3(10), CAPN5(9), CAPN6(7), CAPN7(8), CAPN9(4), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CSK(7), DOCK1(17), FYN(10), GIT2(2), GRB2(4), ILK(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(13), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAPK10(5), MAPK12(1), MAPK4(6), MAPK6(1), MAPK7(6), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PDPK1(2), PIK3R2(12), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(10), RHO(7), ROCK1(18), ROCK2(12), SDCCAG8(5), SHC1(7), SHC3(10), SORBS1(9), SOS1(7), SRC(3), TLN1(22), TNS1(27), VASP(2), VAV2(12), VAV3(10), VCL(6), ZYX(7) 57422581 677 158 651 238 219 153 29 127 137 12 0.488 1.000 1.000 254 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(8), AKT3(6), BTK(4), FCER1A(3), FYN(10), GAB2(3), GRB2(4), IL13(2), IL3(1), IL4(1), INPP5D(4), KRAS(28), LAT(3), LCP2(7), LYN(5), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP2K7(24), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MS4A2(2), NRAS(4), PDK1(3), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PRKCA(5), PRKCD(7), PRKCE(14), RAC2(2), RAC3(4), RAF1(10), SOS1(7), SOS2(19), SYK(7), TNF(3), VAV1(9), VAV2(12), VAV3(10) 30919393 508 154 430 118 140 166 14 94 91 3 7.02e-06 1.000 1.000 255 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(20), BDKRB1(2), BDKRB2(4), C1QA(5), C1QB(1), C1QC(2), C1R(5), C1S(7), C2(2), C3(29), C3AR1(8), C4BPA(3), C4BPB(3), C5(11), C5AR1(5), C6(12), C7(3), C8A(5), C8B(14), C9(7), CD46(3), CD55(3), CFB(7), CFH(21), CFI(13), CPB2(10), CR1(27), CR2(22), F10(7), F11(3), F12(3), F13A1(14), F13B(16), F2(9), F2R(3), F3(1), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), KNG1(9), MASP1(1), MASP2(6), MBL2(4), PLAT(7), PLAU(7), PLAUR(4), PLG(14), PROC(3), PROS1(9), SERPINA1(7), SERPINA5(7), SERPINC1(4), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(7), TFPI(4), THBD(1), VWF(28) 38840565 533 153 499 148 140 128 25 124 114 2 0.0296 1.000 1.000 256 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(8), AKT3(6), BCL10(2), BLNK(4), BTK(4), CARD11(20), CD19(4), CD22(5), CD72(2), CD79A(6), CD79B(2), CD81(6), CHUK(4), CR2(22), FCGR2B(1), FOS(1), GSK3B(5), IFITM1(1), IKBKB(7), INPP5D(4), JUN(4), KRAS(28), LILRB3(5), LYN(5), MALT1(4), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(4), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PTPN6(4), RAC2(2), RAC3(4), RASGRP3(5), SYK(7), VAV1(9), VAV2(12), VAV3(10) 31972797 501 151 419 132 141 160 13 93 93 1 0.000401 1.000 1.000 257 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(19), ABCA12(31), ABCA13(52), ABCA2(18), ABCA3(17), ABCA4(17), ABCA5(24), ABCA6(16), ABCA7(13), ABCA8(13), ABCA9(16), ABCB1(26), ABCB10(12), ABCB11(9), ABCB4(24), ABCB5(16), ABCB6(9), ABCB7(4), ABCB8(8), ABCB9(4), ABCC1(15), ABCC10(10), ABCC11(16), ABCC12(17), ABCC2(12), ABCC3(11), ABCC4(18), ABCC5(11), ABCC6(14), ABCC8(17), ABCC9(34), ABCD1(6), ABCD2(4), ABCD3(5), ABCD4(8), ABCG1(10), ABCG2(6), ABCG4(4), ABCG5(2), ABCG8(5), CFTR(14), TAP1(4), TAP2(13) 50558397 621 150 588 200 173 167 23 127 120 11 0.0882 1.000 1.000 258 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGAP1(4), ARHGAP4(5), ARHGEF11(18), BTK(4), CDC42(1), CFL1(1), CFL2(1), GDI1(3), GDI2(4), INPPL1(24), ITPR1(24), ITPR2(30), ITPR3(36), LIMK1(4), MYLK(32), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDK1(3), PIK3CA(72), PIK3CD(11), PIK3CG(21), PIK3R1(11), PITX2(6), PPP1R13B(11), PTEN(29), RACGAP1(7), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), SAG(4), WASF1(5), WASL(3) 30086758 485 150 411 112 139 136 21 71 105 13 0.000124 1.000 1.000 259 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(43), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(8), CTNNB1(22), DVL1(7), DVL2(6), DVL3(12), FBXW2(3), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LDLR(11), MAPK10(5), MAPK9(3), MYC(5), PAFAH1B1(12), PLAU(7), PPP2R5C(7), PPP2R5E(5), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), PRKD1(20), RHOA(17), SFRP4(6), TCF7(9), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT16(15), WNT2(4), WNT2B(10), WNT3(5), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7) 25793609 457 150 418 142 137 91 15 93 110 11 0.115 1.000 1.000 260 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(5), ALG6(2), CCKBR(9), CCR2(6), CCR3(6), CCR5(4), CELSR1(37), CELSR2(31), CELSR3(51), CHRM2(17), CHRM3(11), CIDEB(2), CXCR3(1), DRD4(3), EDNRA(4), EMR2(9), EMR3(4), F2R(3), FSHR(20), GHRHR(4), GNRHR(4), GPR116(13), GPR132(4), GPR133(13), GPR135(8), GPR143(4), GPR17(5), GPR18(2), GPR55(7), GPR56(5), GPR61(7), GPR77(5), GPR84(2), GPR88(1), GRM1(31), GRPR(7), HRH4(3), LGR6(12), LPHN2(19), LPHN3(17), LTB4R2(4), NTSR1(7), OR2M4(5), OR8G2(5), P2RY13(4), PTGFR(5), SMO(13), SSTR2(4), TAAR5(6), TSHR(10), VN1R1(3) 28590771 464 148 451 151 147 120 24 113 56 4 0.0364 1.000 1.000 261 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(39), ASH2L(5), C17orf79(2), CARM1(5), CTCFL(11), DOT1L(11), EED(5), EHMT1(14), EHMT2(12), EZH1(5), EZH2(6), FBXO11(11), HCFC1(17), HSF4(7), JMJD4(1), JMJD6(3), KDM6A(12), MEN1(8), MLL(36), MLL2(90), MLL3(71), MLL4(30), MLL5(20), NSD1(24), OGT(5), PAXIP1(5), PPP1CA(2), PPP1CB(1), PPP1CC(5), PRDM2(30), PRDM7(2), PRDM9(18), PRMT1(7), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), RBBP5(3), SATB1(16), SETD1A(18), SETD2(18), SETD7(2), SETDB1(18), SETDB2(10), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(5), SUV39H2(2), SUV420H1(11), SUV420H2(3), SUZ12(3), WHSC1(16), WHSC1L1(17) 50987438 696 147 640 190 180 165 20 111 187 33 0.105 1.000 1.000 262 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(6), ALG10(11), ALG10B(8), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG6(2), ALG8(4), ALG9(2), B3GNT1(3), B3GNT2(3), B3GNT6(4), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT5(6), B4GALT7(5), C1GALT1(3), C1GALT1C1(7), CHPF(2), CHST1(14), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST2(14), CHST3(3), CHST4(6), CHST6(11), CHST7(7), CHSY1(6), DPAGT1(4), EXT1(19), EXT2(6), EXTL1(8), EXTL2(2), EXTL3(10), FUT11(3), FUT8(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL1(11), GALNTL2(10), GALNTL4(12), GALNTL5(3), GANAB(11), GCNT3(3), GCNT4(4), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), MGAT5B(5), NDST1(11), NDST2(9), NDST3(13), NDST4(12), OGT(5), RPN1(3), RPN2(6), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST6GALNAC1(4), STT3B(5), UST(9), WBSCR17(25), XYLT1(12), XYLT2(35) 47288612 658 147 605 232 211 144 20 120 156 7 0.856 1.000 1.000 263 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(16), AMY2A(3), AMY2B(14), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(6), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENPP1(7), ENPP3(8), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), G6PC2(1), GAA(5), GANC(9), GBA(9), GBA3(2), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), IFIH1(8), LYZL1(5), MGAM(15), MOV10L1(6), PGM1(3), PGM3(11), PYGB(10), PYGL(8), PYGM(14), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SI(27), SKIV2L2(8), SMARCA2(22), SMARCA5(7), TREH(3), UGDH(5), UGP2(7), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UXS1(4) 52961020 609 143 599 188 167 165 16 132 126 3 0.168 1.000 1.000 264 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(9), CD14(2), CD19(4), CD1A(10), CD1B(7), CD1C(9), CD1D(8), CD1E(7), CD2(3), CD22(5), CD33(6), CD34(4), CD36(2), CD37(3), CD38(4), CD3E(2), CD3G(1), CD4(15), CD44(5), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(1), CD9(1), CR1(27), CR2(22), CSF1(2), CSF1R(15), CSF2RA(9), CSF3(2), CSF3R(13), DNTT(3), EPO(1), EPOR(3), FCER2(2), FLT3(10), FLT3LG(1), GP5(7), GP9(3), GYPA(3), HLA-DRA(8), IL11(3), IL11RA(3), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL7(1), IL7R(9), IL9R(3), ITGA1(8), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(7), KIT(12), KITLG(3), MME(7), MS4A1(1), TFRC(2), THPO(6), TNF(3), TPO(24) 34991248 447 143 410 144 114 98 19 111 100 5 0.349 1.000 1.000 265 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CDH1(30), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), RHOA(17), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3) 22562244 333 142 314 101 79 98 11 87 55 3 0.0795 1.000 1.000 266 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CDH1(30), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), RHOA(17), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3) 22562244 333 142 314 101 79 98 11 87 55 3 0.0795 1.000 1.000 267 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), BCR(11), BLNK(4), BTK(4), CD19(4), CD22(5), CD81(6), CR2(22), CSK(7), DAG1(13), FLOT1(4), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPP5D(4), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP4K1(4), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(17), NR0B2(3), PDK1(3), PIK3CA(72), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PTPRC(19), RAF1(10), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9) 31761589 482 142 422 124 147 141 12 90 87 5 0.000262 1.000 1.000 268 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(8), AKT3(6), BRD4(11), CAP1(5), CBL(3), CDC42(1), CDKN2A(13), F2RL2(3), FLOT1(4), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), IGFBP1(9), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), LNPEP(11), MAPK1(3), MAPK3(1), PARD3(11), PARD6A(1), PDK1(3), PIK3CA(72), PIK3CD(11), PIK3R1(11), PPYR1(7), PTEN(29), PTPN1(3), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(4), SORBS1(9), SOS1(7), SOS2(19), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 25539462 428 142 362 101 129 119 9 65 98 8 0.000453 1.000 1.000 269 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(8), AKT3(6), BCR(11), BTK(4), CD19(4), CDKN2A(13), DAPP1(1), FLOT1(4), FLOT2(5), GAB1(3), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), NR0B2(3), PDK1(3), PHF11(4), PIK3CA(72), PITX2(6), PLCG2(15), PPP1R13B(11), PREX1(16), PTEN(29), PTPRC(19), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SAG(4), SYK(7), TEC(4), VAV1(9) 23683899 386 141 333 108 114 114 11 72 66 9 0.0160 1.000 1.000 270 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5E(6), INPPL1(24), IPMK(1), ISYNA1(4), ITGB1BP3(2), ITPK1(4), ITPKA(2), ITPKB(11), MINPP1(5), MIOX(5), OCRL(9), PI4KA(15), PI4KB(5), PIK3C3(14), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PTEN(29), PTPMT1(1), SYNJ1(10), SYNJ2(17) 31843959 472 140 403 119 142 140 11 86 88 5 0.000367 1.000 1.000 271 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(8), BAD(3), BCL2(3), CABIN1(15), CALM1(2), CALM2(2), CAMK2B(4), CAMK4(8), CD3E(2), CD3G(1), CD69(3), CDKN1A(3), CNR1(11), CREBBP(40), CSNK2A1(6), CSNK2B(1), CTLA4(3), EGR2(8), EGR3(6), EP300(21), FCER1A(3), FCGR3A(4), FOS(1), FOSL1(1), GATA3(17), GATA4(4), GRLF1(15), GSK3A(3), GSK3B(5), ICOS(2), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(2), IL1B(3), IL2RA(3), IL3(1), IL4(1), IL8(2), ITK(6), JUNB(3), KPNA5(6), MAP2K7(24), MAPK14(1), MAPK8(6), MAPK9(3), MEF2A(2), MEF2B(5), MEF2D(7), MYF5(5), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB2(7), NFKBIB(6), NPPB(2), NUP214(22), OPRD1(2), P2RX7(1), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(5), PPP3R1(4), PTPRC(19), RELA(5), RPL13A(4), SFN(1), SLA(4), SP1(6), SP3(3), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(9), VAV2(12), VAV3(10), XPO5(4) 39117050 516 139 496 173 162 135 17 101 97 4 0.189 1.000 1.000 272 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BTRC(9), CSNK1A1(3), CSNK1A1L(6), CSNK1D(2), CSNK1E(8), CSNK1G1(6), CSNK1G2(5), CSNK1G3(8), DHH(2), FBXW11(10), GAS1(4), GLI1(20), GLI2(14), GLI3(47), GSK3B(5), HHIP(16), IHH(7), LRP2(60), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), PTCH1(23), PTCH2(10), RAB23(2), SHH(4), SMO(13), STK36(11), SUFU(5), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT16(15), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4), ZIC2(5) 26079867 466 139 432 138 159 98 16 88 99 6 0.0423 1.000 1.000 273 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(5), CAMK1(2), CAMK1G(6), CAMK4(8), CREBBP(40), CSNK1A1(3), EDN1(3), ELSPBP1(3), F2(9), FGF2(3), FKBP1A(2), GATA4(4), GSK3B(5), HAND1(3), HAND2(2), IGF1(4), LIF(2), MAP2K1(5), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), MEF2C(4), MYH2(29), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKX2-5(4), NPPA(2), PIK3CA(72), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RAF1(10), RPS6KB1(5), SYT1(4) 21776161 376 137 326 93 119 113 15 64 63 2 3.56e-05 1.000 1.000 274 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(16), CPEB1(5), EGFR(15), ERBB2(15), ERBB4(47), ETS1(8), ETS2(4), ETV6(7), ETV7(5), FMN2(38), GRB2(4), KRAS(28), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(27), NOTCH2(25), NOTCH3(22), NOTCH4(16), PIWIL1(6), PIWIL2(8), PIWIL3(5), PIWIL4(7), RAF1(10), SOS1(7), SOS2(19), SPIRE1(7), SPIRE2(4) 22411491 364 136 319 111 103 95 12 92 58 4 0.134 1.000 1.000 275 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(5), APOA1(8), CD36(2), CITED2(3), CPT1B(5), CREBBP(40), DUSP1(2), DUT(2), EHHADH(7), EP300(21), HSD17B4(6), HSPA1A(2), JUN(4), LPL(7), MAPK1(3), MAPK3(1), ME1(2), MYC(5), NCOA1(17), NCOR1(26), NCOR2(30), NFKBIA(1), NR0B2(3), NR1H3(6), NR2F1(7), NRIP1(17), PDGFA(2), PIK3CA(72), PIK3R1(11), PPARA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PTGS2(7), RB1(13), RELA(5), RXRA(6), SP1(6), SRA1(1), STAT5A(3), STAT5B(14), TNF(3) 27117053 415 134 364 107 100 138 13 77 84 3 0.000980 1.000 1.000 276 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(43), AR(14), ASAH1(4), BRAF(16), CAMP(2), CCL15(2), CCL16(1), DAG1(13), EGFR(15), GNA11(6), GNA15(3), GNAI1(1), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CA(72), PIK3CD(11), PIK3R1(11), PITX2(6), PTX3(2), RAF1(10), SRC(3) 22908304 387 134 333 99 112 116 18 67 61 13 0.000398 1.000 1.000 277 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(4), ATP8A1(9), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(2), EDNRA(4), EDNRB(29), FPR1(6), FSHR(20), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GNRHR(4), GPR77(5), GRPR(7), LHCGR(11), MC2R(2), MC3R(9), MC4R(5), MC5R(5), NMBR(4), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), PPYR1(7), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), TAC4(3), TACR1(3), TACR2(1), TACR3(15), TRHR(5), TSHR(10) 22501647 385 133 365 137 141 98 12 76 56 2 0.110 1.000 1.000 278 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(8), AKT3(6), BRAF(16), CAB39(1), EIF4B(5), EIF4EBP1(2), FIGF(4), HIF1A(7), IGF1(4), MAPK1(3), MAPK3(1), PDPK1(2), PGF(2), PIK3CA(72), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(7), RHEB(1), RICTOR(20), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), STK11(3), TSC1(7), TSC2(12), ULK1(16), ULK2(11), VEGFB(1), VEGFC(9) 22746600 360 131 303 88 109 104 15 59 71 2 0.00211 1.000 1.000 279 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCR(11), BLNK(4), BTK(4), CD19(4), CSK(7), DAG1(13), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PI3(2), PIK3CA(72), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), RAF1(10), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9) 22631676 340 131 290 94 99 107 9 65 58 2 0.0109 1.000 1.000 280 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), DAG1(13), DGKA(7), ETFA(1), GCA(2), ITGA9(8), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAPK1(3), MAPK3(1), NR1I3(4), PAK1(5), PDE3A(13), PDE3B(20), PI3(2), PIK3C2G(10), PIK3CA(72), PIK3CD(11), PIK3R1(11), PLDN(1), PSME1(3), RIPK3(5), RPS4X(1), SGCB(4), VASP(2) 20868046 318 129 270 76 89 108 13 58 46 4 9.33e-05 1.000 1.000 281 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(4), BRAF(16), CAMP(2), CREB1(3), CREB3(7), CREB5(5), CREBBP(40), CRKL(1), DAG1(13), EGR1(10), EGR2(8), EGR3(6), EGR4(6), ELK1(3), FRS2(4), GNAQ(4), JUN(4), MAP1B(20), MAP2K4(9), MAP2K7(24), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), NTRK1(10), OPN1LW(6), PIK3C2G(10), PIK3CA(72), PIK3CD(11), PIK3R1(11), PTPN11(6), RPS6KA3(4), SHC1(7), SRC(3), TERF2IP(5), TH(3) 22011662 379 129 326 90 115 119 8 62 73 2 2.20e-05 1.000 1.000 282 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(9), ADCY6(14), ADCY8(31), CACNA1A(24), CACNA1B(24), GNAS(27), GNAT3(5), GNB1(1), GNB3(1), GNG13(2), GRM4(11), ITPR3(36), KCNB1(12), PDE1A(7), PLCB2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), SCNN1B(7), SCNN1G(4), TAS1R1(7), TAS1R2(10), TAS1R3(8), TAS2R1(3), TAS2R10(3), TAS2R13(3), TAS2R14(5), TAS2R16(9), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(2), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(3), TAS2R9(1), TRPM5(6) 24420446 340 127 329 122 124 84 14 71 45 2 0.353 1.000 1.000 283 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(34), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADIPOQ(3), ADIPOR1(5), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(8), AKT3(6), CAMKK1(5), CAMKK2(2), CD36(2), CHUK(4), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), G6PC2(1), IKBKB(7), IRS1(24), IRS2(6), IRS4(27), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), MAPK10(5), MAPK8(6), MAPK9(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NPY(2), PCK1(11), PCK2(9), POMC(8), PPARA(4), PPARGC1A(10), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKCQ(10), PTPN11(6), RELA(5), RXRA(6), RXRB(4), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(7), STK11(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(8) 35581356 449 127 430 145 142 89 11 98 101 8 0.368 1.000 1.000 284 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(3), BRAF(16), CHUK(4), CREB1(3), DAXX(10), ELK1(3), FOS(1), GRB2(4), IKBKB(7), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(24), MAP3K1(11), MAP3K10(8), MAP3K11(10), MAP3K12(15), MAP3K13(9), MAP3K14(5), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP3K9(3), MAP4K1(4), MAP4K2(7), MAP4K3(4), MAP4K4(10), MAP4K5(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(6), MAPK8(6), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MKNK2(7), MYC(5), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(7), RAF1(10), RELA(5), RIPK1(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(6), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4) 40745192 454 127 440 149 142 104 20 76 108 4 0.316 1.000 1.000 285 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(8), CLK2(11), CLK3(12), CLK4(4), COL2A1(17), CPSF1(19), CPSF2(4), CPSF3(3), CPSF4(3), CSTF1(8), CSTF2(5), CSTF2T(7), CSTF3(8), DDIT3(4), DDX1(7), DDX20(4), DHX15(10), DHX16(6), DHX38(16), DHX8(13), DHX9(7), DICER1(11), DNAJC8(4), GIPC1(4), NCBP1(5), NCBP2(3), NONO(4), NUDT21(2), NXF1(7), PABPN1(3), PAPOLA(5), PHF5A(1), POLR2A(19), PPM1G(4), PRPF18(2), PRPF3(6), PRPF4(6), PRPF4B(11), PRPF8(16), PSKH1(7), PTBP1(6), PTBP2(1), RBM17(2), RBM5(8), RNGTT(4), RNMT(9), SF3A1(3), SF3A2(2), SF3A3(3), SF3B1(7), SF3B2(17), SF3B4(5), SF4(5), SFRS12(4), SFRS14(6), SFRS16(6), SFRS4(5), SFRS5(7), SFRS6(5), SFRS7(2), SFRS8(13), SFRS9(1), SNRPA(8), SNRPA1(4), SNRPB(2), SNRPB2(2), SNRPD1(3), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(8), SPOP(3), SRPK1(3), SRPK2(8), SRRM1(12), SUPT5H(13), U2AF1(4), U2AF2(10), XRN2(14) 45433080 526 127 509 148 181 135 22 86 97 5 0.0897 1.000 1.000 286 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(3), BDKRB2(4), CALM1(2), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(5), FLT1(16), FLT4(24), KDR(13), NOS3(10), PDE2A(14), PDE3A(13), PDE3B(20), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKG1(9), PRKG2(13), RYR2(82), SLC7A1(6), SYT1(4), TNNI1(2) 17362439 284 127 275 95 85 71 9 74 45 0 0.225 1.000 1.000 287 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(16), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), CARM1(5), COMT(4), DBH(6), DCT(13), DDC(12), ECH1(1), ESCO1(7), ESCO2(8), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HEMK1(1), HGD(4), HPD(1), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), MIF(1), MYST3(28), MYST4(20), NAT6(3), PNMT(8), PNPLA3(2), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SH3GLB1(3), TAT(5), TH(3), TPO(24), TYR(9), TYRP1(4), WBSCR22(6) 25504001 362 125 332 101 98 81 9 79 89 6 0.0895 1.000 1.000 288 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(6), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(2), CCL5(2), CDC42(1), CHUK(4), CSK(7), EGFR(15), F11R(2), GIT1(3), HBEGF(1), IGSF5(3), IKBKB(7), IL8(2), JAM2(2), JAM3(8), JUN(4), LYN(5), MAP2K4(9), MAP3K14(5), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(6), MAPK9(3), MET(8), NFKB1(7), NFKB2(7), NFKBIA(1), NOD1(11), PAK1(5), PLCG1(19), PLCG2(15), PTPN11(6), PTPRZ1(25), RELA(5), SRC(3), TCIRG1(7), TJP1(21) 30148788 360 124 335 119 95 81 10 83 90 1 0.547 1.000 1.000 289 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MIOX(5), OCRL(9), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3CA(72), PIK3CB(13), PIK3CG(21), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15) 19197485 316 124 260 75 85 102 14 59 55 1 0.00235 1.000 1.000 290 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRKL(1), DOCK1(17), ELK1(3), FOS(1), GAB1(3), GRB2(4), HGF(15), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(1), MAPK8(6), MET(8), PAK1(5), PIK3CA(72), PIK3R1(11), PTEN(29), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAF1(10), RAP1A(2), RAP1B(6), RASA1(17), SOS1(7), SRC(3), STAT3(7) 18949641 305 123 247 70 68 95 13 63 59 7 0.000667 1.000 1.000 291 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CHPT1(3), CRLS1(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), ESCO1(7), ESCO2(8), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(10), GPD1(7), GPD1L(3), GPD2(6), LCAT(4), LYPLA1(1), LYPLA2(2), MYST3(28), MYST4(20), NAT6(3), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(15), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(4), PTDSS2(3), SH3GLB1(3) 28056530 338 118 329 117 110 86 11 68 61 2 0.383 1.000 1.000 292 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(8), AKT3(6), ANKRD6(6), APC(43), AXIN1(9), AXIN2(15), CER1(2), CSNK1A1(3), CTNNB1(22), DACT1(10), DKK1(9), DKK2(5), DKK3(3), DKK4(3), DVL1(7), FSTL1(3), GSK3A(3), GSK3B(5), LRP1(47), MVP(7), NKD1(10), NKD2(1), PIN1(2), PSEN1(3), PTPRA(11), SENP2(4), SFRP1(4), TSHB(3), WIF1(2) 17297677 259 118 237 81 78 61 4 47 57 12 0.407 1.000 1.000 293 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(2), CSK(7), CTLA4(3), DAG1(13), EPHB2(12), FBXW7(28), GRAP2(4), GRB2(4), ITK(6), ITPKA(2), ITPKB(11), LAT(3), LCK(4), LCP2(7), MAPK1(3), NCK1(6), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PLCG1(19), PTPRC(19), RAF1(10), RASGRP1(8), RASGRP2(8), RASGRP3(5), RASGRP4(4), SOS1(7), SOS2(19), VAV1(9), ZAP70(14) 23943160 333 116 313 95 115 75 11 68 62 2 0.0561 1.000 1.000 294 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(43), ATF2(3), AXIN1(9), BMP10(4), BMP2(5), BMP4(6), BMP5(11), BMP7(7), BMPR1A(5), BMPR2(16), CHRD(9), CTNNB1(22), DVL1(7), FZD1(10), GATA4(4), GSK3B(5), MAP3K7(10), MEF2C(4), MYL2(8), NKX2-5(4), NOG(1), NPPA(2), NPPB(2), RFC1(9), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), WNT1(8) 15607883 261 115 250 76 65 62 9 47 67 11 0.224 1.000 1.000 295 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(8), AKT3(6), ASAH1(4), BRAF(16), DAG1(13), DRD2(9), EGFR(15), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), PI3(2), PIK3CB(13), PITX2(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), RAF1(10), RGS20(6), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT3(7), TERF2IP(5) 25101444 355 115 339 116 121 85 11 70 63 5 0.273 1.000 1.000 296 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(2), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CASP9(3), CFLAR(1), CHUK(4), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), GSN(11), LMNA(6), LMNB1(4), LMNB2(6), MAP2K7(24), MAP3K1(11), MAP3K14(5), MAP3K5(5), MAPK8(6), MDM2(5), NFKB1(7), NFKBIA(1), NUMA1(25), PAK2(7), PRKCD(7), PRKDC(40), PSEN1(3), PSEN2(2), PTK2(11), RASA1(17), RB1(13), RELA(5), RIPK1(2), SPTAN1(20), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4) 29629282 344 114 332 102 101 84 18 53 85 3 0.159 1.000 1.000 297 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), AK3(5), CAD(18), CANT1(4), CTPS(1), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), ITPA(1), NME6(3), NME7(1), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NT5M(5), NUDT2(4), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), TK1(1), TK2(3), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UPB1(4), UPP1(1), UPP2(7), UPRT(6), ZNRD1(1) 34739336 372 114 361 115 124 88 13 68 76 3 0.100 1.000 1.000 298 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(2), CDK5R1(4), CFL1(1), CHN1(3), LIMK1(4), MAP3K1(11), MYL2(8), MYLK(32), NCF2(4), PAK1(5), PDGFRA(15), PIK3CA(72), PIK3R1(11), PLD1(19), PPP1R12B(15), RALBP1(8), RPS6KB1(5), TRIO(39), VAV1(9), WASF1(5) 14997283 275 114 224 66 68 100 6 46 52 3 0.00515 1.000 1.000 299 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AGK(6), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AKR1A1(1), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DAK(8), DGAT1(3), DGAT2(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), GK(3), GK2(7), GLA(3), GLB1(5), GPAM(10), LCT(22), LIPA(3), LIPC(4), LIPF(5), LIPG(4), LPL(7), MGLL(1), PNLIP(4), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4) 25140442 302 112 291 102 83 80 9 63 65 2 0.331 1.000 1.000 300 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(7), AKT1(3), APC(43), ASAH1(4), CAMP(2), CAV3(2), DAG1(13), DLG4(3), EPHB2(12), GNAI1(1), GNAQ(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), PITX2(6), PTX3(2), RHO(7), RYR1(61) 19684467 286 111 278 95 104 63 9 51 46 13 0.165 1.000 1.000 301 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(7), ACTN2(23), ACTN3(4), BCAR1(8), BCR(11), CAPN1(5), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(7), FYN(10), GRB2(4), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MAPK8(6), PPP1R12B(15), PTK2(11), PXN(4), RAF1(10), RAP1A(2), ROCK1(18), SHC1(7), SOS1(7), SRC(3), TLN1(22), VCL(6), ZYX(7) 20180510 243 110 234 80 86 58 10 51 35 3 0.164 1.000 1.000 302 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(43), AXIN1(9), CREBBP(40), CTNNB1(22), DVL1(7), EP300(21), FZD1(10), GSK3B(5), HDAC1(5), LDB1(5), LEF1(8), PITX2(6), TRRAP(49), WNT1(8) 14224454 238 110 225 66 77 52 6 41 52 10 0.0606 1.000 1.000 303 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), AVP(3), CABIN1(15), CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), HDAC5(11), IGF1(4), IGF1R(16), INSR(14), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(7), NFATC1(13), NFATC2(17), PIK3CA(72), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYT1(4), YWHAH(3) 14924393 252 109 208 67 77 89 10 38 37 1 0.000959 1.000 1.000 304 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(19), ARHGEF1(11), F2(9), F2R(3), F2RL3(3), GNA12(1), GNA13(5), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP3K7(10), PIK3CA(72), PIK3R1(11), PLCB1(18), PPP1R12B(15), PRKCA(5), PTK2B(16), ROCK1(18) 11094789 225 109 184 53 58 85 6 38 35 3 0.00186 1.000 1.000 305 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(8), AKT3(6), CISH(3), GRB2(4), IARS(10), IL13RA1(4), IL2RG(6), IL4(1), IL4R(3), INPP5D(4), JAK1(12), JAK2(13), JAK3(13), NR0B2(3), PI3(2), PIK3CA(72), PPP1R13B(11), RPS6KB1(5), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT6(3), TYK2(8) 15829097 232 109 186 51 49 86 6 42 47 2 0.00366 1.000 1.000 306 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(22), CALR(5), CANX(3), CD4(15), CD74(1), CD8A(4), CD8B(1), CIITA(16), CREB1(3), CTSB(3), CTSL1(2), CTSS(2), HLA-A(16), HLA-B(14), HLA-C(13), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(12), HLA-G(5), HSP90AA1(11), HSP90AB1(6), HSPA5(2), IFI30(2), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(3), KIR2DS4(2), KIR3DL1(7), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), LGMN(6), LTA(4), NFYA(1), NFYC(2), PDIA3(3), PSME1(3), PSME2(1), RFX5(11), RFXANK(4), RFXAP(1), TAP1(4), TAP2(13), TAPBP(7) 19941948 300 108 265 67 43 72 21 63 91 10 0.0248 1.000 1.000 307 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), F10(7), F11(3), F12(3), F2(9), F2R(3), F5(21), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), PROC(3), PROS1(9), SERPINC1(4), SERPING1(7) 19074452 216 108 213 69 53 56 7 62 37 1 0.226 1.000 1.000 308 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(13), AR(14), ESR1(9), ESR2(9), ESRRA(2), HNF4A(8), NR0B1(5), NR1D1(5), NR1D2(6), NR1H2(7), NR1H3(6), NR1I2(7), NR1I3(4), NR2C2(3), NR2E1(3), NR2F1(7), NR2F2(3), NR2F6(3), NR3C1(6), NR4A1(4), NR4A2(12), NR5A1(5), NR5A2(5), PGR(15), PPARA(4), PPARD(8), PPARG(4), RARA(3), RARB(7), RARG(1), ROR1(10), RORA(6), RORC(6), RXRA(6), RXRB(4), RXRG(5), THRA(6), THRB(9), VDR(2) 18034824 242 108 236 99 89 50 13 50 39 1 0.834 1.000 1.000 309 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(9), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), CDC42(1), CFL1(1), CFL2(1), FLNA(26), FLNC(26), FSCN1(5), FSCN3(11), GDI1(3), GDI2(4), LIMK1(4), MYH2(29), MYLK(32), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PFN2(2), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), VASP(2), WASF1(5), WASL(3) 20534986 262 108 247 86 93 61 8 45 50 5 0.222 1.000 1.000 310 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(16), AMY2A(3), AMY2B(14), ENPP1(7), ENPP3(8), GAA(5), GANAB(11), GBA3(2), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), MGAM(15), PGM1(3), PGM3(11), PYGB(10), PYGL(8), PYGM(14), SI(27), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4), UXS1(4) 24355756 267 108 263 87 67 80 6 57 57 0 0.299 1.000 1.000 311 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(5), CAD(18), CANT1(4), CTPS(1), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ITPA(1), NT5C(1), NT5E(2), NT5M(5), NUDT2(4), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), RRM1(5), RRM2(4), TK1(1), TK2(3), TXNRD1(6), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UNG(2), UPB1(4), UPP1(1) 24588387 266 107 254 88 70 65 10 58 60 3 0.439 1.000 1.000 312 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(19), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CREB1(3), GNAS(27), GRB2(4), MAPK1(3), MAPK14(1), MAPK3(1), PIK3CA(72), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RPS6KA1(9), RPS6KA5(3), SOS1(7) 12518359 216 106 172 55 63 85 5 29 32 2 0.0102 1.000 1.000 313 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(2), ABP1(16), ACAT1(5), ACAT2(4), ACMSD(5), AFMID(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CARM1(5), CAT(5), CYP1A1(5), CYP1A2(5), CYP1B1(2), DDC(12), EHHADH(7), GCDH(8), HAAO(1), HADH(3), HADHA(4), HEMK1(1), HSD17B4(6), INMT(3), KMO(4), KYNU(11), LCMT1(1), LCMT2(11), LNX1(3), MAOA(2), MAOB(3), METTL6(3), NFX1(5), OGDH(11), OGDHL(16), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), TDO2(7), TPH1(3), TPH2(7), WARS(5), WARS2(10), WBSCR22(6) 25968564 331 105 298 99 80 83 12 53 97 6 0.305 1.000 1.000 314 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(3), CHUK(4), DAXX(10), EGF(9), EGFR(15), ETS1(8), ETS2(4), FOS(1), HOXA7(4), IKBKB(7), JUN(4), MAP2K1(5), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP2K7(24), MAP3K1(11), MAP3K14(5), MAP3K5(5), MAPK1(3), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), NFKB1(7), NFKBIA(1), PPP2CA(2), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), RAF1(10), RELA(5), RIPK1(2), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4) 21076467 255 105 246 84 89 58 7 47 51 3 0.151 1.000 1.000 315 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(16), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), COMT(4), DBH(6), DCT(13), DDC(12), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HGD(4), HPD(1), MAOA(2), MAOB(3), PNMT(8), TAT(5), TH(3), TPO(24), TYR(9) 13597567 220 105 197 62 58 47 3 53 55 4 0.198 1.000 1.000 316 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(14), GABBR1(15), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM7(20), GRM8(22) 9011198 192 104 183 76 83 30 11 45 23 0 0.536 1.000 1.000 317 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(6), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(6), QDPR(3), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SKIV2L2(8), SMARCA2(22), SMARCA5(7), SPR(2) 26941169 324 104 318 110 115 70 8 66 63 2 0.486 1.000 1.000 318 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ABP1(16), ACAT1(5), ACAT2(4), ACMSD(5), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CAT(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP4F8(2), CYP51A1(8), DDC(12), EHHADH(7), GCDH(8), HAAO(1), HADHA(4), KMO(4), KYNU(11), MAOA(2), MAOB(3), SDS(4), TDO2(7), TPH1(3), WARS(5), WARS2(10) 23632529 318 104 291 86 84 76 6 61 88 3 0.129 1.000 1.000 319 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADH(3), HADHA(4), HSD17B4(6), HSD3B7(6), NSD1(24), OGDH(11), OGDHL(16), PIPOX(3), PLOD1(7), PLOD2(13), PLOD3(16), RDH11(1), RDH12(3), RDH13(5), SETD1A(18), SETD7(2), SETDB1(18), SHMT1(4), SHMT2(9), SPCS1(3), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5) 24889355 319 103 294 92 98 75 9 53 80 4 0.123 1.000 1.000 320 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), ABO(1), B3GALNT1(3), B3GALT1(3), B3GALT2(7), B3GALT4(7), B3GALT5(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALNT1(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT6(4), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GBGT1(2), GCNT2(2), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(11), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGX(2), PIGZ(4), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8), UGCG(3) 20790706 262 103 243 90 87 50 6 47 69 3 0.747 1.000 1.000 321 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(8), BAD(3), BAX(6), BCL2(3), BCL2L2(2), BOK(1), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP8(18), CASP9(3), CD40(3), CD40LG(5), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKE(12), LTA(4), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(6), NTRK1(10), PTPN13(24), RIPK1(2), SFRS2IP(13), TFG(1), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4), TRAF6(6) 18603066 219 102 205 69 45 47 16 51 58 2 0.459 1.000 1.000 322 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(19), AKT1(3), ASAH1(4), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(13), ITGB3(7), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(15), PIK3CA(72), PIK3R1(11), PLCB1(18), PRKCA(5), PTK2(11), SMPD1(8), SMPD2(3), SPHK1(6), SRC(3) 11782104 209 102 166 57 52 88 8 27 33 1 0.00925 1.000 1.000 323 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), G6PC2(1), GALM(4), GAPDH(2), GAPDHS(4), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKL(5), PFKM(3), PFKP(15), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1) 24964559 303 102 289 106 78 90 9 68 57 1 0.425 1.000 1.000 324 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(16), AGXT(1), AGXT2(8), AKR1B10(6), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(7), GNMT(4), HSD3B7(6), MAOA(2), MAOB(3), PEMT(1), PHGDH(3), PIPOX(3), PISD(5), PSAT1(5), PSPH(2), RDH11(1), RDH12(3), RDH13(5), SARDH(13), SARS(8), SARS2(7), SDS(4), SHMT1(4), SHMT2(9), TARS(7), TARS2(7) 18301593 236 102 223 76 71 61 14 39 49 2 0.314 1.000 1.000 325 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(38), BMPR1B(7), CCND2(3), DMC1(8), EGR1(10), ESR2(9), FSHR(20), GJA4(4), INHA(5), LHCGR(11), MLH1(6), MSH5(4), NCOR1(26), NR5A1(5), NRIP1(17), PGR(15), PRLR(4), PTGER2(5), SMPD1(8), VDR(2), ZP2(9) 15014208 216 102 202 59 48 60 11 45 48 4 0.0855 1.000 1.000 326 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DGAT1(3), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), GK(3), GLA(3), GLB1(5), LCT(22), LIPC(4), LIPF(5), LIPG(4), LPL(7), PNLIP(4), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(3), PPAP2B(1), PPAP2C(4) 20656971 252 101 241 93 71 64 7 52 56 2 0.626 1.000 1.000 327 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(16), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), DDC(12), EPX(9), ESCO1(7), ESCO2(8), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MIF(1), MPO(7), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), PRDX6(2), SH3GLB1(3), TAT(5), TPO(24) 14678695 216 101 197 57 61 45 6 50 52 2 0.152 1.000 1.000 328 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(8), AKT3(6), ARHGEF11(18), BCL2(3), CDC42(1), DLG4(3), GNA13(5), LPA(16), MAP2K4(9), MAP3K1(11), MAP3K5(5), MAPK8(6), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PDK1(3), PHKA2(10), PI3(2), PIK3CB(13), PLD1(19), PLD2(15), PLD3(6), PTK2(11), RDX(7), ROCK1(18), ROCK2(12), SERPINA4(2), SRF(2), TBXA2R(8) 21046269 261 101 247 71 83 63 11 36 63 5 0.0849 1.000 1.000 329 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(16), AGMAT(2), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH4A1(4), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(3), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), GAMT(1), GATM(3), GLUD1(2), GOT1(3), GOT2(2), MAOA(2), MAOB(3), NOS1(28), NOS3(10), OAT(2), ODC1(3), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(3), PYCR1(1), RARS(5), SMS(5) 18952255 255 100 237 73 74 66 10 47 57 1 0.116 1.000 1.000 330 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(19), AKT1(3), BAD(3), BAX(6), BCL2(3), CSF2RB(9), IGF1(4), IGF1R(16), IL3(1), IL3RA(5), KIT(12), KITLG(3), PIK3CA(72), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), YWHAH(3) 9425285 201 100 155 54 47 84 7 32 30 1 0.00655 1.000 1.000 331 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(18), ATP4A(17), ATP4B(4), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(2), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(2), COX15(6), COX4I1(6), COX4I2(1), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), COX8C(4), CYC1(3), LHPP(4), NDUFA1(1), NDUFA10(4), NDUFA12(2), NDUFA13(3), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(4), NDUFAB1(2), NDUFB11(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(2), NDUFC2(1), NDUFS1(9), NDUFS2(5), NDUFS3(1), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(5), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), SDHD(1), TCIRG1(7), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1) 23898581 302 100 278 102 95 72 11 59 65 0 0.569 1.000 1.000 332 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(6), APH1A(1), CREBBP(40), CTBP1(3), CTBP2(8), DLL1(15), DLL3(7), DLL4(4), DTX1(14), DTX2(5), DTX3(2), DTX3L(2), DTX4(7), DVL1(7), DVL2(6), DVL3(12), EP300(21), HDAC1(5), HDAC2(2), JAG1(12), JAG2(8), MAML1(5), MAML2(7), MAML3(8), NCOR2(30), NCSTN(7), NOTCH1(27), NOTCH2(25), NOTCH3(22), NOTCH4(16), NUMB(3), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(2), PTCRA(2), RBPJ(8), RBPJL(6), RFNG(2), SNW1(5) 29602732 371 100 361 156 135 82 14 63 76 1 0.855 1.000 1.000 333 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(45), B3GALT4(7), CDR1(5), DGKI(15), IL6ST(6), PIGK(3), RPL10(7), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL15(1), RPL18(1), RPL19(2), RPL22(2), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(1), RPL5(3), RPL6(2), RPL7(1), RPL7A(5), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(2), RPS11(2), RPS13(3), RPS14(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS27(1), RPS27A(2), RPS3(2), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(4), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), RPS7(1), RPS9(1), RPSA(2), SLC36A2(7), TBC1D10C(5), TSPAN9(2), UBA52(2), UBC(9) 22452226 246 100 238 77 62 68 11 50 53 2 0.520 1.000 1.000 334 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(23), ACACB(34), ACAT1(5), ACAT2(4), ACOT12(5), ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), LDHD(5), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PCK2(9), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7), PKM2(6) 20067838 253 99 240 86 76 67 7 50 50 3 0.460 1.000 1.000 335 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(2), ACADM(4), ACOX1(5), ACOX2(6), ACOX3(11), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADIPOQ(3), ANGPTL4(2), APOA1(8), APOA5(4), AQP7(2), CD36(2), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), CYP27A1(5), CYP4A11(2), CYP4A22(2), CYP7A1(6), CYP8B1(7), EHHADH(7), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(3), GK2(7), HMGCS2(3), ILK(8), LPL(7), ME1(2), MMP1(2), NR1H3(6), OLR1(2), PCK1(11), PCK2(9), PDPK1(2), PLTP(2), PPARA(4), PPARD(8), PPARG(4), RXRA(6), RXRB(4), RXRG(5), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(6), SLC27A4(10), SLC27A5(5), SLC27A6(8), SORBS1(9), UBC(9), UCP1(3) 28118351 302 99 291 100 107 53 20 65 54 3 0.369 1.000 1.000 336 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(2), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CLC(1), CPT1B(5), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), ETNK1(2), GNPAT(1), GPD1(7), GPD2(6), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(12), PAFAH2(3), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB2(8), PLCG1(19), PLCG2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4) 21391784 246 98 233 89 78 62 8 46 50 2 0.606 1.000 1.000 337 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(16), AGXT(1), AGXT2(8), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CPT1B(5), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(7), MAOA(2), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(19), PLCG2(15), PSPH(2), SARDH(13), SARS(8), SHMT1(4), SHMT2(9), TARS(7) 18004346 229 98 216 72 65 54 11 44 53 2 0.376 1.000 1.000 338 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(5), EEF1B2(3), EEF1D(5), EEF1G(3), EEF2(9), EEF2K(10), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(5), EIF2AK3(15), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4A1(4), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4EBP2(2), EIF4G1(23), EIF4G3(17), EIF5(6), EIF5A(5), EIF5B(21), ETF1(4), GSPT2(6), KIAA0664(16), PABPC1(2), PABPC3(10), PAIP1(1), SLC35A4(6) 18741103 232 98 215 56 64 62 8 44 51 3 0.0199 1.000 1.000 339 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(16), CARM1(5), CCND1(1), CREBBP(40), EP300(21), ERCC3(8), ESR1(9), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(11), HDAC6(7), MEF2C(4), NCOR2(30), NR0B1(5), NRIP1(17), PELP1(6), POLR2A(19), SRA1(1), TBP(3) 19723106 275 97 262 75 94 70 7 45 57 2 0.0148 1.000 1.000 340 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1C1(3), AKR1C2(1), AKR1C3(2), AKR1C4(6), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), CYP1A1(5), CYP1A2(5), CYP1B1(2), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2F1(4), CYP2S1(6), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(9), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), MGST1(3), MGST2(3), MGST3(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6) 24504533 253 97 243 68 58 70 4 66 54 1 0.0797 1.000 1.000 341 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(5), ALOX15(7), ALOX5(10), CBR1(1), CBR3(2), CYP4F2(6), CYP4F3(11), EPX(9), GGT1(6), LPO(9), LTA4H(5), MPO(7), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4), TPO(24) 11969089 176 97 169 51 61 29 10 43 31 2 0.125 1.000 1.000 342 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(2), CASP2(3), CASP3(2), CASP8(18), CRADD(1), DFFA(4), DFFB(3), FADD(1), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MADD(17), MAP2K4(9), MAP3K1(11), MAP3K7(10), MAPK8(6), PAK1(5), PAK2(7), PRKDC(40), RB1(13), RIPK1(2), SPTAN1(20), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 16611978 210 96 204 64 55 53 13 33 53 3 0.321 1.000 1.000 343 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CDK5(2), F2(9), FYN(10), GNA11(6), GNAI1(1), GNB1(1), GNGT1(3), GRB2(4), JAK2(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPT(7), MYLK(32), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), SYT1(4) 17859302 223 95 210 75 73 58 8 42 39 3 0.374 1.000 1.000 344 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(7), F11(3), F12(3), F13B(16), F2(9), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), LPA(16), PLAT(7), PLAU(7), PLG(14), SERPINB2(8), SERPINE1(3), SERPINF2(8), VWF(28) 15158900 207 95 199 54 56 45 9 57 39 1 0.0644 1.000 1.000 345 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(8), CDC7(4), CDK2(3), CDT1(7), DIAPH2(7), GMNN(1), MCM10(10), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), NACA(2), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), PRIM1(2), RFC1(9), RFC2(1), RFC3(3), RFC4(1), RFC5(1), RPA1(2), RPA2(2), RPA3(2), RPA4(6), RPS27A(2), UBA52(2), UBC(9) 21753848 220 95 214 63 76 43 12 39 48 2 0.142 1.000 1.000 346 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(19), CALM1(2), CALM2(2), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(4), GNAS(27), GNB1(1), GNGT1(3), JUN(4), MAP2K1(5), MAPK3(1), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RAF1(10), RPS6KA3(4), SYT1(4) 15033057 220 95 209 69 89 52 4 35 40 0 0.0875 1.000 1.000 347 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), HRH1(5), HRH2(8), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10) 11062835 229 95 222 81 89 50 13 50 27 0 0.116 1.000 1.000 348 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(10), AKT1(3), AKT2(8), AKT3(6), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PDK1(3), PHKA2(10), PIK3CB(13), PITX2(6), PLD1(19), PLD2(15), PLD3(6), VN1R1(3) 19243480 261 95 253 70 93 59 14 48 44 3 0.0210 1.000 1.000 349 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CFLAR(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAF1(8), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MAP2K4(9), MAP3K1(11), MAP3K7(10), MAPK8(6), PAK1(5), PAK2(7), PRKDC(40), PTPN13(24), RB1(13), RIPK2(1), SPTAN1(20) 17413099 224 94 216 63 48 63 13 38 60 2 0.165 1.000 1.000 350 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(2), ALDH4A1(4), ALDH5A1(6), CAD(18), CPS1(22), EARS2(3), EPRS(12), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GFPT2(5), GLS(8), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), GMPS(7), GNPNAT1(4), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSR(5), GSS(3), NADSYN1(8), NAGK(1), PPAT(5), QARS(5) 16949877 185 94 183 71 52 53 7 45 28 0 0.740 1.000 1.000 351 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(5), ARHGAP5(18), ARHGAP6(9), ARHGEF1(11), ARHGEF11(18), ARHGEF5(5), ARPC1A(3), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(11), GSN(11), LIMK1(4), MYL2(8), MYLK(32), OPHN1(9), PIP5K1A(4), PIP5K1B(1), PPP1R12B(15), ROCK1(18), SRC(3), TLN1(22), VCL(6) 19475904 232 94 211 74 66 57 11 37 57 4 0.475 1.000 1.000 352 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(3), PFKP(15), PGK1(4), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1) 20976024 260 93 247 93 65 73 7 61 53 1 0.614 1.000 1.000 353 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(3), PFKP(15), PGK1(4), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1) 20976024 260 93 247 93 65 73 7 61 53 1 0.614 1.000 1.000 354 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(6), APC(43), AXIN1(9), BTRC(9), CTNNB1(22), DLL1(15), DVL1(7), FZD1(10), GSK3B(5), NOTCH1(27), PSEN1(3), WNT1(8) 9169493 164 93 150 52 47 28 6 28 46 9 0.422 1.000 1.000 355 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(4), CALM1(2), CALM2(2), CD79A(6), CD79B(2), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK14(1), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9) 16430692 200 92 192 56 78 48 5 32 36 1 0.0291 1.000 1.000 356 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(6), CALCRL(8), CD97(4), CRHR1(11), CRHR2(4), ELTD1(17), EMR1(13), EMR2(9), GHRHR(4), GIPR(3), GLP1R(1), GLP2R(8), GPR64(12), LPHN1(19), LPHN2(19), LPHN3(17), SCTR(3), VIPR1(3), VIPR2(3) 11421754 171 90 166 52 44 43 7 54 21 2 0.104 1.000 1.000 357 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(6), AKR1D1(3), ARSD(4), ARSE(5), CARM1(5), CYP11B1(12), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD11B2(3), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(1), HSD17B7(3), HSD3B1(4), HSD3B2(3), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SRD5A1(3), SRD5A2(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), WBSCR22(6) 21453585 223 90 216 70 54 70 9 40 49 1 0.169 1.000 1.000 358 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(16), ACY3(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CARM1(5), CNDP1(6), DDC(12), FTCD(5), HAL(4), HARS(9), HARS2(4), HDC(8), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), PRPS1(3), PRPS2(3), UROC1(10), WBSCR22(6) 16980760 228 90 203 58 56 55 8 40 65 4 0.0782 1.000 1.000 359 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), ELK1(3), FPR1(6), GNA15(3), GNB1(1), GNGT1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NCF1(3), NCF2(4), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(10), PLCB1(18), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), RELA(5), SYT1(4) 16399444 195 89 185 67 68 44 4 36 43 0 0.385 1.000 1.000 360 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACADVL(1), ACAT1(5), ACAT2(4), ACOX1(5), ACOX3(11), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), CYP4A11(2), CYP4A22(2), DCI(4), EHHADH(7), GCDH(8), HADH(3), HADHA(4), HADHB(5), HSD17B4(6), PECI(3) 21011347 231 89 216 64 52 64 7 50 56 2 0.0868 1.000 1.000 361 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(3), ACAA2(5), ACADM(4), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), AUH(7), BCAT1(5), BCAT2(6), BCKDHA(15), BCKDHB(3), DBT(5), DLD(4), EHHADH(7), HADH(3), HADHA(4), HADHB(5), HIBADH(3), HMGCS1(2), HMGCS2(3), HSD17B4(6), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), OXCT2(3), PCCA(8), PCCB(5) 18452974 213 89 197 70 46 59 4 40 61 3 0.632 1.000 1.000 362 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(3), ARG2(2), ASL(6), ASS1(9), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), EPRS(12), GAMT(1), GATM(3), GLUD1(2), GLUD2(11), GOT1(3), GOT2(2), LAP3(2), NOS1(28), NOS3(10), OAT(2), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), PYCR1(1), PYCR2(1), PYCRL(2), RARS(5), RARS2(6) 15394352 182 89 178 52 59 46 10 41 26 0 0.0818 1.000 1.000 363 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(9), AADAC(5), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ACSM1(5), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), BDH1(5), DDHD1(12), EHHADH(7), GAD1(7), GAD2(9), HADH(3), HADHA(4), HMGCS1(2), HMGCS2(3), HSD17B4(6), HSD3B7(6), ILVBL(5), L2HGDH(2), OXCT1(8), OXCT2(3), PDHA1(1), PDHA2(6), PDHB(4), PLA1A(2), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(5) 17394750 199 89 186 76 62 45 4 42 45 1 0.800 1.000 1.000 364 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F1(5), GTF2F2(2), GTF2H1(2), GTF2H3(2), GTF2H4(7), GTF2I(4), GTF2IRD1(13), TAF1(20), TAF10(1), TAF13(1), TAF1L(29), TAF2(13), TAF4(12), TAF4B(3), TAF5(2), TAF5L(6), TAF6(12), TAF6L(5), TAF7(7), TAF7L(7), TAF9B(4), TBPL1(2), TBPL2(7) 15449868 181 89 174 43 49 39 10 34 49 0 0.0486 1.000 1.000 365 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(8), AZIN1(2), CBX3(1), CLDN5(3), CLOCK(5), CRY1(3), CRY2(5), DAZAP2(6), DNAJA1(6), EIF4G2(7), ETV6(7), G0S2(2), GFRA1(9), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(4), IDI1(2), KLF9(2), MYF6(5), NCKAP1(9), NCOA4(5), NR1D2(6), PER1(4), PER2(15), PIGF(1), PPP1R3C(4), PPP2CB(3), PSMA4(4), PURA(1), SF3A3(3), SUMO3(3), TOB1(1), TUBB3(13), UCP3(3), UGP2(7), VAPA(3), ZFR(13) 15664745 180 88 176 55 51 43 9 38 38 1 0.321 1.000 1.000 366 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(4), B4GALT5(6), C1GALT1(3), C1GALT1C1(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL1(11), GALNTL2(10), GALNTL4(12), GALNTL5(3), GCNT3(3), GCNT4(4), OGT(5), ST3GAL1(4), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(25) 13869210 188 88 179 68 64 40 8 37 38 1 0.828 1.000 1.000 367 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(5), ALOX12B(10), ALOX15(7), ALOX15B(3), ALOX5(10), CBR1(1), CBR3(2), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP2U1(6), CYP4A11(2), CYP4A22(2), CYP4F2(6), CYP4F3(11), DHRS4(1), EPHX2(4), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GPX6(4), GPX7(3), LTA4H(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4) 16697472 196 88 189 52 67 46 6 45 31 1 0.0196 1.000 1.000 368 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(12), ADRBK2(5), ARRB2(1), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CLCA1(10), CLCA2(6), CLCA4(12), CNGA3(8), CNGA4(19), CNGB1(15), GNAL(3), GUCA1A(3), GUCA1B(2), GUCA1C(4), PDC(2), PDE1C(11), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(9), PRKG2(13), PRKX(5) 13099384 178 88 170 58 58 38 5 41 35 1 0.284 1.000 1.000 369 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(6), AARS2(11), ABAT(3), ACY3(1), ADSL(5), ADSS(5), ADSSL1(8), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), ASRGL1(2), ASS1(9), CAD(18), CRAT(5), DARS(2), DARS2(3), DDO(6), DLAT(3), DLD(4), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15), PDHA1(1), PDHA2(6), PDHB(4) 16218924 171 87 168 67 62 46 1 36 26 0 0.759 1.000 1.000 370 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(6), AARS2(11), CARS(4), CARS2(5), DARS(2), DARS2(3), EARS2(3), EPRS(12), FARS2(7), FARSA(3), FARSB(1), GARS(4), HARS(9), HARS2(4), IARS(10), IARS2(9), KARS(5), LARS(5), LARS2(7), MARS(4), MARS2(2), MTFMT(1), NARS(5), QARS(5), RARS(5), RARS2(6), SARS(8), SARS2(7), TARS(7), TARS2(7), VARS(16), VARS2(12), WARS(5), WARS2(10), YARS(6), YARS2(2) 23293919 218 87 214 70 71 63 9 43 32 0 0.363 1.000 1.000 371 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(6), ARSB(2), FUCA1(1), FUCA2(2), GALNS(1), GBA(9), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(22), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NAGLU(6), NEU1(3), NEU2(6), NEU3(5), NEU4(2), SPAM1(9) 14764926 190 87 186 60 59 52 9 32 36 2 0.233 1.000 1.000 372 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(9), ADCY3(12), ADCY9(13), AK1(1), ARF1(5), ARF4(1), ARF5(1), ARL4D(1), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(1), GNAS(27), PDIA4(3), PLCG1(19), PLCG2(15), PRKCA(5), SEC61A1(5), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(5) 15886250 203 87 190 70 78 37 6 42 40 0 0.556 1.000 1.000 373 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(4), ELK1(3), FOS(1), IKBKB(7), IRAK1(6), JUN(4), LY96(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP3K7(10), MAPK14(1), MAPK8(6), MYD88(4), NFKB1(7), NFKBIA(1), PPARA(4), RELA(5), TIRAP(1), TLR10(7), TLR2(2), TLR3(6), TLR4(21), TLR6(3), TLR7(5), TLR9(16), TOLLIP(5), TRAF6(6) 15655244 171 87 164 57 48 37 7 38 39 2 0.397 1.000 1.000 374 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(19), CD3E(2), CD3G(1), CD4(15), CREBBP(40), CSK(7), GNAS(27), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14) 9877316 191 85 174 69 68 48 2 30 43 0 0.644 1.000 1.000 375 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(19), CD3E(2), CD3G(1), CD4(15), CREBBP(40), CSK(7), GNAS(27), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14) 9877316 191 85 174 69 68 48 2 30 43 0 0.644 1.000 1.000 376 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(18), CPS1(22), EPRS(12), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GLS(8), GLS2(7), GLUD1(2), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSS(3), NADSYN1(8), PPAT(5), QARS(5) 14245065 154 85 154 55 45 46 5 35 23 0 0.593 1.000 1.000 377 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(6), ALDOC(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GAPDHS(4), GCK(4), GOT1(3), GOT2(2), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MDH1(3), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PFKL(5), PFKM(3), PFKP(15), PGAM2(5), PGK1(4), PGK2(3), PKLR(7), PKM2(6), TNFAIP1(4), TPI1(1) 18230069 201 85 195 86 67 59 4 39 31 1 0.864 1.000 1.000 378 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(18), ATP4B(4), ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B1(22), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(12), ATP7B(13), COX10(2), COX4I1(6), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(9), NDUFS2(5), NDUFV1(5), PPA2(3), SDHA(6), SDHB(4), SHMT1(4), UQCRB(1), UQCRC1(2), UQCRFS1(1) 16358567 217 84 194 66 63 49 8 40 56 1 0.414 1.000 1.000 379 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(23), ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHB(4), LDHC(1), LDHD(5), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7), PKM2(6) 15844517 192 84 182 70 57 56 4 35 38 2 0.670 1.000 1.000 380 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(11), BLNK(4), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8IP3(13), PAPPA(25), RPS6KA1(9), RPS6KA3(4), SHC1(7), SOS1(7), SYK(7), VAV1(9), VAV2(12), VAV3(10) 13738984 158 84 153 62 51 44 3 32 27 1 0.640 1.000 1.000 381 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(7), ACTN2(23), ACTN3(4), CAPN1(5), CAPNS1(2), CAPNS2(2), ITGA1(8), ITGB1(10), ITGB3(7), PTK2(11), PXN(4), SPTAN1(20), SRC(3), TLN1(22) 12238790 131 84 126 62 57 28 8 25 13 0 0.918 1.000 1.000 382 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(16), ACADL(2), ACADM(4), ACADSB(7), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SDS(4), SMS(5), UPB1(4) 12474673 183 83 166 50 42 50 3 37 50 1 0.125 1.000 1.000 383 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(16), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), DDC(12), EPX(9), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), TAT(5), TPO(24) 9422339 149 83 132 42 39 28 5 35 40 2 0.380 1.000 1.000 384 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(2), ATF2(3), CALM1(2), CALM2(2), EGFR(15), ELK1(3), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PAK1(5), PRKCA(5), PTK2(11), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4) 14383282 166 82 159 53 56 35 9 26 39 1 0.270 1.000 1.000 385 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(16), ACADM(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SMS(5), SRM(1), UPB1(4) 11585589 160 82 143 42 37 41 3 32 46 1 0.106 1.000 1.000 386 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(6), ALG10(11), ALG10B(8), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG5(3), ALG6(2), ALG8(4), ALG9(2), B4GALT1(2), B4GALT2(7), B4GALT3(2), DHDDS(4), DOLPP1(3), DPAGT1(4), DPM1(1), FUT8(7), GANAB(11), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), MGAT5B(5), RFT1(4), RPN1(3), RPN2(6), STT3B(5) 18165510 182 82 172 72 43 41 6 31 57 4 0.967 1.000 1.000 387 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(3), ALAS2(12), BLVRA(4), BLVRB(1), COX10(2), COX15(6), CP(10), CPOX(2), EARS2(3), EPRS(12), FECH(6), FTH1(4), FTMT(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), MMAB(3), PPOX(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UROD(1), UROS(4) 18014594 180 82 179 61 37 51 8 46 38 0 0.606 1.000 1.000 388 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(6), POLA2(4), POLB(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLG(8), POLG2(5), POLH(6), POLI(2), POLK(8), POLL(3), POLM(11), POLQ(33), PRIM1(2), PRIM2(4), REV1(8), REV3L(38), RFC5(1) 17386129 200 82 186 60 51 42 5 33 67 2 0.639 1.000 1.000 389 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), BAIAP2(5), CASP1(4), CASP3(2), CASP7(3), CASP8(18), GAPDH(2), INSR(14), ITCH(5), MAGI1(18), MAGI2(30), RERE(28), WWP1(12), WWP2(13) 10294463 162 82 149 42 38 35 9 27 53 0 0.183 1.000 1.000 390 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADHA(4), PLOD1(7), PLOD2(13), PLOD3(16), SDS(4), SHMT1(4), SHMT2(9), TMLHE(5) 15854463 207 82 186 63 55 54 3 30 63 2 0.266 1.000 1.000 391 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(5), CAPN2(8), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(15), ITGA1(8), ITGB1(10), MAPK1(3), MAPK3(1), MYL2(8), MYLK(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTK2(11), PXN(4), TLN1(22) 14031620 175 82 158 66 60 39 9 29 36 2 0.637 1.000 1.000 392 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(2), DLG4(3), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), NOS1(28), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), SYT1(4) 10962140 155 82 151 60 55 35 5 31 29 0 0.554 1.000 1.000 393 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(6), CFL1(1), GNAQ(4), GNAS(27), GNB1(1), GNGT1(3), LIMK1(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), NOX1(6), PIK3C2G(10), PLCB1(18), PPP1R12B(15), PRKCA(5), PTK2(11), RAF1(10), ROCK2(12) 10800778 151 81 143 42 56 27 4 32 31 1 0.291 1.000 1.000 394 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(15), ELK1(3), GNAS(27), GNB1(1), GNGT1(3), GRB2(4), IGF1R(16), ITGB1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MYC(5), NGFR(4), PDGFRA(15), PPP2CA(2), PTPRR(12), RAF1(10), RPS6KA1(9), RPS6KA5(3), SHC1(7), SOS1(7), SRC(3), STAT3(7) 14218333 186 81 175 81 68 46 0 45 26 1 0.915 1.000 1.000 395 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(5), ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1B10(6), AKR1C4(6), AKR1D1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), HSD3B7(6), LIPA(3), RDH11(1), RDH12(3), RDH13(5), SLC27A5(5), SOAT1(7), SOAT2(2), SRD5A1(3), SRD5A2(3) 13577969 182 81 170 49 40 57 9 39 36 1 0.0465 1.000 1.000 396 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(23), ACACB(34), ACADM(4), ACAT1(5), ACAT2(4), ACSS1(12), ACSS2(10), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SUCLA2(4), SUCLG1(2), SUCLG2(5) 17041403 209 81 192 58 50 55 5 44 51 4 0.185 1.000 1.000 397 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(12), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(3), ANAPC7(6), BTRC(9), CDC16(7), CDC20(5), CDC23(6), CDC26(1), CDC27(3), CUL1(22), CUL2(6), CUL3(6), FBXW11(10), FBXW7(28), FZR1(7), ITCH(5), RBX1(1), SKP2(5), SMURF1(5), SMURF2(5), TCEB1(1), UBA1(4), UBE2D3(2), UBE2E3(3), VHL(2), WWP1(12), WWP2(13) 17205517 199 81 180 43 68 52 2 30 47 0 0.00440 1.000 1.000 398 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), FPGT(4), FUK(5), GMDS(2), GMPPA(6), GMPPB(6), HK1(16), HK2(10), HK3(6), HSD3B7(6), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(5), MTMR6(7), PFKFB1(6), PFKFB2(6), PFKFB3(7), PFKFB4(4), PFKL(5), PFKM(3), PFKP(15), PGM2(1), PHPT1(2), PMM1(2), PMM2(2), RDH11(1), RDH12(3), RDH13(5), SORD(2), TPI1(1), TSTA3(8) 15931702 196 80 190 59 73 56 5 28 34 0 0.0412 1.000 1.000 399 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(3), BRAF(16), CREB1(3), CREB3(7), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(5), EEF2K(10), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MOS(11), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), SHC1(7), SOS1(7), SOS2(19), TRAF3(4) 12642981 160 80 150 60 41 37 3 36 41 2 0.812 1.000 1.000 400 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), DAG1(13), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFAT5(10), PDE6A(4), PDE6B(10), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(7), TF(15) 15339132 185 80 181 70 68 46 11 32 25 3 0.441 1.000 1.000 401 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(2), CHUK(4), EGR2(8), EGR3(6), GNAQ(4), MAP3K1(11), MYC(5), NFATC1(13), NFATC2(17), NFKB1(7), NFKBIA(1), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), SYT1(4), VIP(5), VIPR2(3) 12007552 168 80 159 48 61 35 3 32 37 0 0.0648 1.000 1.000 402 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(6), B4GALT1(2), B4GALT2(7), G6PC2(1), GAA(5), GALE(3), GALK1(4), GALK2(2), GALT(1), GANC(9), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), LALBA(1), LCT(22), MGAM(15), PFKL(5), PFKM(3), PFKP(15), PGM1(3), PGM3(11), RDH11(1), RDH12(3), RDH13(5), UGP2(7) 16536364 187 79 177 78 68 49 5 26 38 1 0.867 1.000 1.000 403 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(3), ANXA3(1), ANXA4(3), ANXA5(3), ANXA6(2), CYP11A1(5), EDN1(3), EDNRA(4), EDNRB(29), HSD11B1(3), HSD11B2(3), PLA2G4A(6), PRL(1), PTGDR(7), PTGDS(1), PTGER2(5), PTGER4(8), PTGFR(5), PTGIS(6), PTGS1(12), PTGS2(7), S100A6(1), SCGB1A1(2), TBXAS1(4) 8852607 126 79 118 46 34 27 8 31 25 1 0.738 1.000 1.000 404 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(8), CALM1(2), CALM2(2), CRKL(1), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), PAK1(5), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4) 12217945 144 79 138 38 50 32 4 24 33 1 0.0845 1.000 1.000 405 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(10), DYRK1B(12), GLI2(14), GLI3(47), GSK3B(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), SHH(4), SMO(13), SUFU(5) 7134953 141 79 134 52 51 25 5 31 27 2 0.426 1.000 1.000 406 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(4), DLG4(3), EPHB2(12), F2(9), F2RL1(2), F2RL2(3), F2RL3(3), JUN(4), MAP2K5(1), MAPK1(3), MAPK7(6), MAPK8(6), MYEF2(9), PLD1(19), PLD2(15), PLD3(6), PTK2(11), RAF1(10), RASAL1(7), SRC(3), TEC(4), VAV1(9) 11762632 149 79 148 44 52 35 6 26 29 1 0.151 1.000 1.000 407 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(8), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP8(18), CASP9(3), CFLAR(1), CHUK(4), DFFA(4), DFFB(3), FADD(1), GAS2(2), LMNA(6), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), SPTAN1(20), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(5), TRADD(2), TRAF2(4) 14322752 134 78 128 37 33 29 5 30 36 1 0.367 1.000 1.000 408 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP4F8(2), CYP51A1(8), PON1(2) 12601131 154 77 150 52 64 31 4 26 29 0 0.310 1.000 1.000 409 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(19), EXT2(6), EXTL1(8), EXTL2(2), EXTL3(10), GLCE(5), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), NDST1(11), NDST2(9), NDST3(13), NDST4(12) 8890710 142 77 137 47 43 35 4 38 19 3 0.454 1.000 1.000 410 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(3), ARSD(4), ARSE(5), ASAH1(4), B4GALT6(4), CERK(6), DEGS1(2), DEGS2(1), ENPP7(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(22), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(3), SGMS2(3), SGPP1(2), SGPP2(1), SMPD1(8), SMPD2(3), SMPD3(10), SMPD4(5), SPHK1(6), SPHK2(3), SPTLC1(2), SPTLC2(3), UGCG(3), UGT8(5) 15329572 166 77 165 63 57 43 8 23 34 1 0.593 1.000 1.000 411 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(18), ARHGEF1(11), GNA12(1), GNA13(5), GNAQ(4), GNB1(1), GNGT1(3), MYL2(8), MYLK(32), PLCB1(18), PPP1R12B(15), PRKCA(5), ROCK1(18) 8871982 139 77 122 40 33 30 2 27 43 4 0.555 1.000 1.000 412 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(4), CREBBP(40), DUSP1(2), EP300(21), IKBKB(7), IL1B(3), IL8(2), MAP2K3(4), MAP2K6(1), MAP3K14(5), MAP3K7(10), MAPK11(1), MAPK14(1), MYD88(4), NFKB1(7), NFKBIA(1), NR3C1(6), RELA(5), TGFBR1(4), TGFBR2(14), TLR2(2), TNF(3) 12711671 147 77 145 42 41 37 7 29 31 2 0.155 1.000 1.000 413 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(8), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F2(2), GTF2H1(2), GTF2H4(7), ILK(8), MNAT1(3), POLR1A(15), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3B(13), POLR3D(6), POLR3E(6), POLR3K(1), TAF13(1), TAF5(2), TAF6(12), TAF7(7), TBP(3) 15030146 160 77 157 46 57 41 3 23 35 1 0.147 1.000 1.000 414 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(23), ACTN3(4), BCAR1(8), CSK(7), CTNNA1(15), CTNNA2(19), CTNNB1(22), PTK2(11), PXN(4), SRC(3), VCL(6) 8205698 129 76 124 52 39 27 8 28 24 3 0.823 1.000 1.000 415 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(16), ACY1(3), ADC(2), AGMAT(2), ALDH18A1(7), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(3), ARG2(2), ASL(6), ASS1(9), CPS1(22), GATM(3), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(5), SRM(1) 12641840 164 76 149 39 40 44 5 33 41 1 0.0616 1.000 1.000 416 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(3), DAXX(10), DDIT3(4), ELK1(3), GRB2(4), HMGN1(2), HSPB2(1), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MYC(5), PLA2G4A(6), RIPK1(2), RPS6KA5(3), SHC1(7), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4) 15731666 159 76 155 50 44 41 7 22 43 2 0.329 1.000 1.000 417 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(15), BCKDHB(3), EHHADH(7), HADHA(4), HADHB(5), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), PCCA(8), PCCB(5), SDS(4) 15440430 195 76 179 66 37 62 3 35 55 3 0.704 1.000 1.000 418 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(39), MAP2(34), PPP1CA(2), PPP2CA(2), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8), PRKCE(14) 7793931 117 75 111 41 18 32 2 36 25 4 0.831 1.000 1.000 419 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(2), B4GALT2(7), FBP2(5), GAA(5), GALE(3), GALK1(4), GALK2(2), GALT(1), GANAB(11), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), LALBA(1), LCT(22), MGAM(15), PFKM(3), PFKP(15), PGM1(3), PGM3(11) 13947676 160 75 151 66 59 41 4 21 35 0 0.827 1.000 1.000 420 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(19), CAP1(5), CCNB1(3), CDC25C(13), GNAI1(1), GNAS(27), GNB1(1), GNGT1(3), MAPK1(3), MAPK3(1), MYT1(19), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RPS6KA1(9), SRC(3) 8854168 143 75 133 55 53 31 1 30 27 1 0.757 1.000 1.000 421 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), ABP1(16), AOC2(6), AOC3(15), CES1(7), CES7(8), DDHD1(12), ESCO1(7), ESCO2(8), LIPA(3), MYST3(28), MYST4(20), NAT6(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(2), SH3GLB1(3) 10873015 148 74 136 39 39 37 5 30 36 1 0.201 1.000 1.000 422 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(8), GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2F1(5), HDAC3(6), NCOA1(17), NCOA2(22), NCOA3(16), NCOR2(30), POLR2A(19), RARA(3), RXRA(6), TBP(3) 10675277 148 74 144 48 44 47 4 25 28 0 0.285 1.000 1.000 423 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(1), CREB1(3), CREB3(7), CREB5(5), DUSP1(2), DUSP10(8), EEF2K(10), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K10(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK1(3), MKNK2(7), MYEF2(9), NFKB1(7), NR2C2(3), SRF(2), TRAF6(6) 14301914 156 74 154 47 37 47 10 27 35 0 0.137 1.000 1.000 424 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(9), ACO1(8), ACO2(9), CLYBL(3), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), OGDHL(16), PC(15), PCK1(11), PCK2(9), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5) 12830038 144 73 137 46 53 32 6 19 29 5 0.296 1.000 1.000 425 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(2), BIRC2(3), BIRC3(6), CASP3(2), CASP8(18), CFLAR(1), FADD(1), JUN(4), MAP2K4(9), MAP3K3(8), MAP3K7(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), NR2C2(3), RALBP1(8), RIPK1(2), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 11686221 144 73 139 39 40 27 10 25 41 1 0.237 1.000 1.000 426 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), P4HB(3), SLC23A1(5), SLC23A2(11), SLC2A1(6), SLC2A3(8) 10760945 126 73 123 50 38 37 3 25 22 1 0.533 1.000 1.000 427 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), L2HGDH(2), OXCT1(8), PDHA1(1), PDHA2(6), PDHB(4), SDHB(4), SDS(4) 11064699 143 72 134 55 41 36 0 30 35 1 0.802 1.000 1.000 428 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(2), CDKN1A(3), GNAQ(4), MARCKS(3), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SP1(6), SP3(3), SYT1(4) 9006258 122 71 117 37 46 31 3 16 26 0 0.0992 1.000 1.000 429 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), FPGT(4), GCK(4), GMDS(2), GMPPA(6), GMPPB(6), HK1(16), HK2(10), HK3(6), KHK(2), MPI(3), PFKFB1(6), PFKFB3(7), PFKFB4(4), PFKM(3), PFKP(15), PMM1(2), PMM2(2), SORD(2), TPI1(1) 10274441 128 71 123 38 51 34 3 19 21 0 0.0707 1.000 1.000 430 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(7), CHIA(4), CHIT1(4), CMAS(7), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(4), GFPT2(5), GNE(7), GNPDA1(4), GNPDA2(6), GNPNAT1(4), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), NAGK(1), NANS(3), NPL(3), PGM3(11), PHPT1(2), RENBP(2), UAP1(5) 12309781 150 71 147 42 39 44 7 28 32 0 0.0652 1.000 1.000 431 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(3), F2RL3(3), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(18), PRKCA(5), PTGS1(12), PTK2(11), RAF1(10), SRC(3), SYK(7), TBXAS1(4) 10447613 123 71 117 50 45 24 6 29 19 0 0.716 1.000 1.000 432 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(8), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), REN(3) 10842746 114 70 112 39 31 31 4 25 22 1 0.350 1.000 1.000 433 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(4), CSNK1D(2), DRD1(3), DRD2(9), GRM1(31), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(2), PPP3CA(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6867076 115 70 110 43 38 29 1 21 26 0 0.613 1.000 1.000 434 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(17), EPHB1(23), FYN(10), ITGA1(8), ITGB1(10), L1CAM(16), LYN(5), RAP1B(6), SELP(10) 6780295 108 70 103 37 39 19 8 32 9 1 0.269 1.000 1.000 435 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CYP2C19(10), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), HADHA(4), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2) 13265815 161 70 150 44 43 45 3 31 38 1 0.126 1.000 1.000 436 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNA1(1), IFNB1(3), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL1RN(1), IRAK1(6), IRAK2(7), IRAK3(6), JUN(4), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP3K7(10), MAPK14(1), MAPK8(6), MYD88(4), NFKB1(7), NFKBIA(1), RELA(5), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3), TOLLIP(5), TRAF6(6) 12735275 141 70 138 39 41 30 5 30 32 3 0.158 1.000 1.000 437 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(29), C5(11), C6(12), C7(3), ICAM1(2), IL1A(2), IL8(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELP(10), SELPLG(7), TNF(3), VCAM1(10) 10638910 135 70 127 44 45 30 4 36 20 0 0.186 1.000 1.000 438 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(5), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1C4(6), AKR1D1(3), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), SOAT2(2), SRD5A1(3), SRD5A2(3) 9967366 144 69 135 42 30 41 5 33 34 1 0.190 1.000 1.000 439 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(4), ASNS(4), ASRGL1(2), CA1(1), CA12(1), CA13(5), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(8), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), HAL(4) 9110531 117 69 113 42 27 37 4 29 20 0 0.617 1.000 1.000 440 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG3(2), ATG5(3), ATG7(5), BECN1(7), GABARAPL1(5), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(14), PIK3R4(11), PRKAA1(6), PRKAA2(7), ULK1(16), ULK2(11) 9046370 117 69 110 30 23 23 8 32 30 1 0.222 1.000 1.000 441 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), FADD(1), IKBKB(7), IL1A(2), IL1R1(4), IRAK1(6), MAP3K1(11), MAP3K14(5), MAP3K7(10), MYD88(4), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TLR4(21), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 10426604 120 69 115 35 32 24 6 31 26 1 0.281 1.000 1.000 442 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(9), EGFR(15), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(22), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SPRY1(3), SPRY3(6), SPRY4(5), SRC(3) 10713395 120 69 115 40 32 26 3 33 26 0 0.601 1.000 1.000 443 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(5), ACAT2(4), ACOT11(6), ACYP1(1), ACYP2(3), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), FN3K(3), GCDH(8), HADHA(4), ITGB1BP3(2), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2) 11150538 132 68 127 31 36 42 5 20 27 2 0.0219 1.000 1.000 444 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(12), BST1(3), C9orf95(2), CD38(4), ENPP1(7), ENPP3(8), NADK(10), NADSYN1(8), NMNAT1(3), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(12), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NT5M(5), NUDT12(4) 9221725 105 68 96 45 24 28 5 17 30 1 0.909 1.000 1.000 445 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EDNRB(29), EGF(9), EGFR(15), FOS(1), JUN(4), MYC(5), NFKB1(7), PLCG1(19), PRKCA(5), RELA(5) 8839446 119 67 110 38 35 21 8 28 26 1 0.404 1.000 1.000 446 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(5), GPLD1(11), PGAP1(8), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(11), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGW(3), PIGX(2), PIGZ(4) 10172108 123 67 110 36 29 29 2 25 35 3 0.428 1.000 1.000 447 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(9), CS(3), DLAT(3), DLD(4), DLST(4), FH(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), PC(15), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PDK1(3), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5) 12176274 118 67 113 50 33 31 4 22 25 3 0.915 1.000 1.000 448 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(23), ACADL(2), ACADM(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SDS(4), SUCLA2(4), SUCLG1(2), SUCLG2(5) 14214282 172 67 158 50 37 55 2 33 42 3 0.343 1.000 1.000 449 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(11), CHAT(4), COMT(4), DBH(6), DDC(12), GAD1(7), GAD2(9), HDC(8), MAOA(2), PAH(5), PNMT(8), SLC18A3(13), TH(3), TPH1(3) 6174548 97 65 91 44 37 17 2 24 16 1 0.873 1.000 1.000 450 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(19), GNAS(27), GNB1(1), GNGT1(3), PPP2CA(2), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6605217 115 65 108 40 42 24 1 19 27 2 0.723 1.000 1.000 451 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(6), ALOX15(7), ALOX5(10), CYP1A2(5), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP3A4(4), CYP3A43(4), CYP3A7(4), HSD3B7(6), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G1B(4), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), RDH11(1), RDH12(3), RDH13(5) 10272939 114 65 110 35 36 34 5 21 18 0 0.201 1.000 1.000 452 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(15), CALM1(2), CALM2(2), CAPN2(8), CAPNS1(2), CAPNS2(2), EP300(21), HDAC1(5), HDAC2(2), MEF2D(7), NFATC1(13), NFATC2(17), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SYT1(4) 10479130 126 65 120 35 50 27 3 21 24 1 0.0599 1.000 1.000 453 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(9), AP2M1(7), ARF1(5), BAD(3), BTK(4), EEA1(13), GRASP(1), GSK3A(3), GSK3B(5), LYN(5), PDPK1(2), PFKL(5), PFKM(3), PFKP(15), PLCG1(19), PRKCE(14), PRKCZ(1), RAB5A(2), RPS6KB1(5), VAV2(12) 10720354 136 65 129 39 42 33 7 23 30 1 0.147 1.000 1.000 454 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(6), ABAT(3), ADSL(5), ADSS(5), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), CAD(18), CRAT(5), DARS(2), DDO(6), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15) 11174678 119 64 116 50 45 32 0 25 17 0 0.801 1.000 1.000 455 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(5), CBS(6), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(11), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), METTL6(3), PAPSS1(6), PAPSS2(5), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SCLY(2), SEPHS1(4), SEPHS2(2), WBSCR22(6) 10696394 113 64 106 43 31 26 6 17 32 1 0.650 1.000 1.000 456 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(3), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), CHST1(14), CHST2(14), CHST4(6), CHST6(11), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6) 5365973 97 64 94 33 50 18 1 12 16 0 0.348 1.000 1.000 457 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(3), CREBBP(40), EP300(21), NCOA3(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RARA(3), RXRA(6) 8872206 125 63 120 38 40 34 2 17 30 2 0.216 1.000 1.000 458 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(9), CD2(3), CD33(6), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL3(1), IL4(1), ITGAX(13), TLR2(2), TLR4(21), TLR7(5), TLR9(16) 7990479 100 63 94 47 28 21 5 34 12 0 0.935 1.000 1.000 459 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(22), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2) 8731153 110 63 107 36 36 24 4 20 25 1 0.452 1.000 1.000 460 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(22), NAGLU(6), SPAM1(9) 8767957 103 63 102 37 33 31 5 17 16 1 0.505 1.000 1.000 461 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(40), EP300(21), LPL(7), NCOA1(17), NCOA2(22), PPARG(4), RXRA(6) 7927613 117 63 113 31 36 32 5 23 20 1 0.0731 1.000 1.000 462 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(17), APOA1(8), APOA4(5), APOC2(1), APOE(2), CETP(5), CYP7A1(6), DGAT1(3), HMGCR(7), LCAT(4), LDLR(11), LIPC(4), LPL(7), LRP1(47), SCARB1(5), SOAT1(7) 11773166 139 63 129 52 51 26 10 28 20 4 0.645 1.000 1.000 463 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(6), CARS(4), DARS(2), EPRS(12), FARS2(7), GARS(4), HARS(9), IARS(10), KARS(5), LARS(5), LARS2(7), MARS(4), MARS2(2), NARS(5), QARS(5), RARS(5), SARS(8), TARS(7), WARS(5), WARS2(10), YARS(6) 13750028 128 62 125 37 39 39 4 25 21 0 0.216 1.000 1.000 464 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(7), B4GALNT1(5), GLB1(5), HEXA(2), HEXB(3), LCT(22), SLC33A1(6), ST3GAL1(4), ST3GAL2(6), ST3GAL5(3), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8) 7066627 95 62 93 40 38 16 5 18 18 0 0.852 1.000 1.000 465 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), JAK1(12), JAK3(13), JUN(4), LCK(4), MAP2K1(5), MAPK3(1), MAPK8(6), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14), SYK(7) 9999634 118 62 110 30 29 33 1 28 26 1 0.125 1.000 1.000 466 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(4), ASNS(4), CA1(1), CA12(1), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(8), GLS2(7), GLUD1(2), GLUL(5), HAL(4) 8154405 99 62 95 39 21 33 3 22 20 0 0.814 1.000 1.000 467 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(40), EP300(21), FADD(1), HDAC3(6), IKBKB(7), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 9586705 114 62 112 35 37 29 3 19 25 1 0.256 1.000 1.000 468 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNH(2), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), CDKN2A(13), CDKN2D(3), E2F1(3), RB1(13), RBL1(11), TFDP1(5) 6889984 86 61 83 31 19 28 2 17 19 1 0.604 1.000 1.000 469 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IL6R(2), IL6ST(6), JAK1(12), JAK2(13), JAK3(13), JUN(4), MAP2K1(5), MAPK3(1), PTPN11(6), RAF1(10), SHC1(7), SOS1(7), SRF(2), STAT3(7) 10248426 109 61 105 39 25 34 1 32 16 1 0.593 1.000 1.000 470 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(15), DDX20(4), E2F1(3), ETS1(8), ETS2(4), FOS(1), HDAC2(2), HDAC5(11), JUN(4), NCOR2(30), RBL1(11), RBL2(8), SIN3A(14), SIN3B(12) 11107755 129 60 125 44 35 23 5 30 36 0 0.717 1.000 1.000 471 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(3), ARSB(2), ARSD(4), ARSE(5), ASAH1(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(22), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(8), SMPD2(3), SPTLC1(2), SPTLC2(3), UGCG(3) 10372839 113 60 112 43 38 32 6 15 22 0 0.612 1.000 1.000 472 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKL(5), PFKM(3), PFKP(15), PGD(6), PGLS(2), PGM1(3), PGM3(11), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(2), RPE(5), RPIA(2), TALDO1(5), TKT(4), TKTL1(10), TKTL2(12) 10417105 130 60 124 41 33 41 6 22 28 0 0.183 1.000 1.000 473 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(15), EGF(9), EGFR(15), GRB2(4), MET(8), PDGFRA(15), PRKCA(5), SH3GLB1(3), SH3GLB2(7), SH3KBP1(15), SRC(3) 8346713 102 59 95 47 31 23 3 17 28 0 0.946 1.000 1.000 474 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(19), ADRB2(8), CFTR(14), GNAS(27), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5625929 99 59 94 40 38 23 0 19 19 0 0.862 1.000 1.000 475 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(17), IL13(2), IL4(1), JUNB(3), MAF(3), MAP2K3(4), MAPK14(1), NFATC1(13), NFATC2(17), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5203055 92 59 85 31 37 21 1 12 21 0 0.193 1.000 1.000 476 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UGDH(5), UGP2(7), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), XYLB(7) 11603295 111 59 108 28 19 33 3 30 26 0 0.162 1.000 1.000 477 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GPX6(4), GPX7(3), GSR(5), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(15), TXNDC12(1) 9412179 107 59 99 34 27 26 3 24 27 0 0.519 1.000 1.000 478 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(11), AMT(4), ATIC(6), FTCD(5), GART(9), MTFMT(1), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(4), SHMT2(9), TYMS(1) 8109297 87 59 82 30 23 18 5 15 24 2 0.391 1.000 1.000 479 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME3(4), PGK1(4), PGK2(3), PKLR(7), PKM2(6), RPE(5), RPIA(2), TKT(4), TKTL1(10), TKTL2(12), TPI1(1) 8666919 97 59 95 42 31 28 5 19 14 0 0.753 1.000 1.000 480 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), ZNRD1(1) 10075177 106 59 104 32 40 30 1 21 14 0 0.166 1.000 1.000 481 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(19), ADRB2(8), GNAS(27), PLCE1(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6367978 99 59 94 46 42 25 0 16 16 0 0.919 1.000 1.000 482 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), CHUK(4), CRADD(1), IKBKB(7), JUN(4), LTA(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP4K2(7), MAPK14(1), MAPK8(6), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 10323491 100 59 98 32 27 22 5 15 29 2 0.496 1.000 1.000 483 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(10), ACE2(8), AGT(3), AGTR1(2), AGTR2(4), ANPEP(9), CMA1(1), CPA3(1), CTSA(4), CTSG(3), ENPEP(12), LNPEP(11), MAS1(2), MME(7), NLN(6), REN(3), THOP1(4) 9073726 90 58 86 39 28 23 4 18 17 0 0.861 1.000 1.000 484 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(12), JAK2(13), JAK3(13), SOCS3(3), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), TYK2(8) 7875134 92 58 88 31 20 26 2 22 21 1 0.648 1.000 1.000 485 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(15), ABCC2(12), ABCG2(6), BCHE(18), CES1(7), CES2(8), CYP3A4(4), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3) 9818652 94 58 92 35 21 26 2 26 18 1 0.709 1.000 1.000 486 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(4), SHMT2(9), TPO(24) 5046162 77 58 74 25 23 10 5 18 19 2 0.543 1.000 1.000 487 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(6), AKR1D1(3), ARSB(2), ARSD(4), ARSE(5), CYP11B1(12), CYP11B2(5), HSD11B1(3), HSD11B2(3), HSD17B2(2), HSD17B3(1), HSD3B1(4), HSD3B2(3), SRD5A1(3), SRD5A2(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4) 11676971 101 57 100 37 32 36 3 16 14 0 0.333 1.000 1.000 488 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(9), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), PC(15), PCK1(11), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(5) 8846734 94 57 88 31 36 21 2 14 19 2 0.360 1.000 1.000 489 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33) 7187553 91 57 85 35 27 16 3 18 26 1 0.879 1.000 1.000 490 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(7), F2(9), F2R(3), F3(1), F5(21), F7(10), FGA(9), FGB(4), FGG(3), PROC(3), PROS1(9), SERPINC1(4), TFPI(4) 7040319 87 57 87 27 26 20 4 27 10 0 0.369 1.000 1.000 491 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(6), IARS(10), IARS2(9), ILVBL(5), LARS(5), LARS2(7), PDHA1(1), PDHA2(6), PDHB(4), VARS(16), VARS2(12) 7978229 86 57 86 31 29 22 2 21 12 0 0.616 1.000 1.000 492 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR7(3), CD28(2), CD4(15), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18R1(3), IL4(1), IL4R(3), TGFB1(3), TGFB2(6), TGFB3(8) 8596921 97 57 88 37 22 21 3 24 26 1 0.817 1.000 1.000 493 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKM(3), PFKP(15), PGD(6), PGLS(2), PGM1(3), PGM3(11), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(2), RPE(5), RPIA(2), TAL1(5), TALDO1(5), TKT(4) 8776582 108 57 103 34 26 33 4 19 26 0 0.248 1.000 1.000 494 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(2), EPRS(12), FECH(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), PPOX(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4), UROD(1), UROS(4) 11715149 103 57 103 37 24 32 2 24 21 0 0.631 1.000 1.000 495 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GCNT2(2), ST3GAL6(4), ST8SIA1(7) 6941063 82 56 77 28 26 19 3 13 21 0 0.619 1.000 1.000 496 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C8B(14), C9(7), MASP1(1) 8920652 102 55 93 29 31 20 5 24 21 1 0.349 1.000 1.000 497 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(19), CREM(4), FHL5(3), FSHB(1), FSHR(20), GNAS(27), XPO1(7) 4133986 81 55 76 28 30 18 2 26 5 0 0.728 1.000 1.000 498 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(11), AMT(4), ATIC(6), GART(9), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(4), SHMT2(9), TYMS(1) 7669366 81 55 76 26 21 18 5 12 24 1 0.262 1.000 1.000 499 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME2(5), ME3(4), PGK1(4), PKLR(7), PKM2(6), RPE(5), RPIA(2), TKT(4), TPI1(1) 7747581 77 54 77 34 23 25 3 15 11 0 0.756 1.000 1.000 500 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(2), RPL10L(12), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(2), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL38(1), RPL3L(3), RPL6(2), RPL7(1), RPL8(2), RPL9(3), RPS11(2), RPS13(3), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(4), RPS6(1), RPS7(1), RPS9(1), RPSA(2) 9698067 82 54 80 27 20 28 3 15 16 0 0.566 1.000 1.000 501 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), SELE(5), SELL(4), SELP(10) 6840070 79 54 75 39 29 15 1 20 14 0 0.890 1.000 1.000 502 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), GBA3(2), LPO(9), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), TPO(24), TYR(9) 4127047 67 54 65 26 18 13 5 20 10 1 0.738 1.000 1.000 503 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(5), ARFGAP1(2), ARFGAP3(5), ARFGEF2(28), CLTA(2), CLTB(1), COPA(9), GBF1(18), GPLD1(11), KDELR1(2), KDELR2(1), KDELR3(3) 6976993 87 53 86 26 29 30 2 13 13 0 0.165 1.000 1.000 504 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15(7), ALOX15B(3), ALOX5(10), ALOX5AP(3), DPEP1(2), GGT1(6), LTA4H(5), PLA2G2A(2), PLA2G6(6), PTGDS(1), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4) 6445417 79 53 78 23 32 15 5 14 12 1 0.124 1.000 1.000 505 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), AMD1(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTAP(1), MTFMT(1), MTR(13), SRM(1), TAT(5) 8894699 93 53 90 49 28 29 2 16 18 0 0.964 1.000 1.000 506 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7), MASP1(1), MASP2(6), MBL2(4) 9135788 98 52 89 31 30 20 5 18 24 1 0.527 1.000 1.000 507 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(9), EGFR(15), ERBB3(37), NRG1(14) 4425787 75 52 65 25 29 20 4 18 4 0 0.327 1.000 1.000 508 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPHN(11), NSF(1), SRC(3), UBQLN1(5) 5132607 84 52 83 29 16 19 10 30 9 0 0.508 1.000 1.000 509 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(9), GBA3(2), LPO(9), MPO(7), PRDX6(2), TPO(24) 3585382 62 52 61 20 21 13 3 16 8 1 0.408 1.000 1.000 510 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(3), JAK1(12), JAK2(13), JAK3(13), PIAS1(12), PIAS3(7), PTPRU(22), REG1A(4), SOAT1(7) 5871529 93 52 86 30 24 24 2 16 26 1 0.725 1.000 1.000 511 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(3), IL6R(2), JAK1(12), JAK2(13), JAK3(13), PIAS3(7), PTPRU(22), REG1A(4), SRC(3), STAT3(7) 6536837 86 52 83 33 24 25 0 19 17 1 0.819 1.000 1.000 512 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(9), EGFR(15), MAP2K1(5), MAP3K1(11), MAPK14(1), NCOR2(30), RARA(3), RXRA(6), THRA(6), THRB(9) 7391765 95 51 88 41 39 20 2 15 19 0 0.830 1.000 1.000 513 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(2), RFK(1), TYR(9) 6452624 76 51 72 21 16 22 4 14 20 0 0.198 1.000 1.000 514 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1D(2), CSNK1E(8), NPAS2(11), NR1D1(5), PER1(4), PER2(15), PER3(12) 7294432 78 51 76 25 22 16 5 19 15 1 0.370 1.000 1.000 515 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), DPAGT1(4), DPM1(1), FUT8(7), MAN1A1(2), MAN1B1(6), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), RPN1(3), RPN2(6) 8554570 83 51 81 42 24 18 5 17 19 0 0.975 1.000 1.000 516 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(12), CD38(4), ENPP1(7), ENPP3(8), NADSYN1(8), NMNAT1(3), NMNAT2(1), NNMT(1), NNT(12), NT5C(1), NT5E(2), NT5M(5) 6230744 64 51 58 29 7 15 4 15 22 1 0.961 1.000 1.000 517 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(9), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(6), PLCB1(18), PLCB2(8), PRL(1), TRH(4), VIP(5) 4767984 69 51 66 26 23 14 4 17 11 0 0.692 1.000 1.000 518 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(8), IFNB1(3), JAK1(12), PTPRU(22), REG1A(4), STAT1(10), STAT2(10), TYK2(8) 5357141 77 51 72 25 24 19 1 11 22 0 0.606 1.000 1.000 519 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(4), DUSP1(2), IKBKAP(12), IKBKB(7), LTA(4), MAP3K1(11), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNFAIP3(10), TNFRSF1B(3), TRAF1(3), TRAF2(4), TRAF3(4) 9635897 87 51 84 33 28 17 3 14 24 1 0.795 1.000 1.000 520 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(5), CYP51A1(8), DHCR24(3), DHCR7(6), EBP(1), FDFT1(2), FDPS(9), GGCX(4), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(1), LSS(9), MVD(2), MVK(13), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(4), SC5DL(4), SQLE(5), TM7SF2(2), VKORC1(1) 8250863 99 50 88 27 23 22 3 21 29 1 0.358 1.000 1.000 521 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(22), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2) 7079699 75 50 75 28 23 16 3 13 19 1 0.749 1.000 1.000 522 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(11), DNMT1(13), MTNR1A(5), MTNR1B(6), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), TBXA2R(8) 4774797 73 50 71 39 30 20 4 14 5 0 0.834 1.000 1.000 523 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(3), IFNG(2), IFNGR1(6), JAK1(12), JAK2(13), PLA2G2A(2), PTPRU(22), REG1A(4), STAT1(10) 4913590 74 50 74 24 20 23 3 13 14 1 0.486 1.000 1.000 524 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(27), GNB1(1), GNGT1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5) 4145607 70 49 65 23 33 11 1 10 15 0 0.593 1.000 1.000 525 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7) 7502145 87 49 79 29 27 18 5 18 18 1 0.637 1.000 1.000 526 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(7), ARG1(3), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), ODC1(3), OTC(2), PYCR1(1), SMS(5) 7505559 76 49 76 23 25 20 3 21 7 0 0.211 1.000 1.000 527 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(22), NAGLU(6) 6152305 65 48 65 30 20 18 1 13 13 0 0.863 1.000 1.000 528 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(23), ACACB(34), FASN(19), MCAT(3), OXSM(4) 6763071 83 48 80 25 23 20 4 20 15 1 0.237 1.000 1.000 529 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), PON1(2), PON2(3), PON3(2) 7742962 82 48 78 39 30 18 1 12 20 1 0.906 1.000 1.000 530 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(9), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(13), MAP2K1(5), MAPK3(1), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14) 7591736 84 47 78 28 23 27 1 18 14 1 0.466 1.000 1.000 531 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(3), CD3E(2), CD3G(1), CD4(15), CXCR3(1), IFNG(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), JAK2(13), STAT4(6), TYK2(8) 6300210 74 47 65 32 8 22 4 16 22 2 0.970 1.000 1.000 532 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(2), CD3E(2), CD3G(1), CD4(15), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1) 4842277 67 47 55 28 14 16 1 16 20 0 0.911 1.000 1.000 533 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(9), NTRK1(10), PIR(1), PSMA7(4), WASF1(5), WASF2(5), WASF3(13), WASL(3) 6535402 71 46 67 30 25 18 2 10 15 1 0.793 1.000 1.000 534 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), IMPA2(2), ISYNA1(4), PGM1(3), PGM3(11), TGDS(4) 5006454 64 46 63 25 21 22 2 12 7 0 0.397 1.000 1.000 535 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6) 6443426 78 46 73 23 19 21 3 11 22 2 0.306 1.000 1.000 536 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(4), IL2RG(6), IL4(1), IL4R(3), IRS1(24), JAK1(12), JAK3(13), RPS6KB1(5), SHC1(7), STAT6(3) 6338702 81 46 75 24 22 20 1 9 28 1 0.612 1.000 1.000 537 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTR(13) 7458581 80 46 77 43 26 23 2 12 17 0 0.959 1.000 1.000 538 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(4), IFNG(2), IKBKB(7), IL4(1), JUN(4), MAP3K1(11), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(6), NFKB1(7), NFKBIA(1), RELA(5), TNFRSF9(11), TRAF2(4) 8291564 73 45 67 19 22 10 3 13 23 2 0.346 1.000 1.000 539 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(4), DUSP1(2), IKBKAP(12), IKBKB(7), MAP3K1(11), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), TNFAIP3(10), TRAF3(4), TRAF6(6) 7779939 74 45 71 24 24 14 2 12 22 0 0.657 1.000 1.000 540 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3E(2), CD3G(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(13), JUN(4), MAP2K6(1), MAPK14(1), MAPK8(6), STAT4(6), TYK2(8) 7995959 77 44 77 33 11 25 5 16 17 3 0.896 1.000 1.000 541 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(10), CD44(5), CSF1(2), FCGR3A(4), IL1B(3), IL6R(2), SELL(4), SPN(4), TGFB1(3), TGFB2(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 5649037 62 44 61 30 21 14 0 12 14 1 0.865 1.000 1.000 542 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(3), FUT2(1), FUT9(6), GBGT1(2), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST8SIA1(7) 4353526 51 43 49 18 25 7 1 12 6 0 0.460 1.000 1.000 543 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(7), ESR1(9), GREB1(22), HSPB2(1), MTA1(8), MTA3(2), PDZK1(2), TUBA8(5) 4688945 57 43 55 24 21 17 3 5 11 0 0.593 1.000 1.000 544 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), PGM1(3), PGM3(11), TGDS(4) 4393173 58 43 58 22 18 22 2 10 6 0 0.371 1.000 1.000 545 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(2), CD3E(2), CD3G(1), CD8A(4), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1) 4615326 56 43 53 25 14 16 2 14 10 0 0.791 1.000 1.000 546 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(5), ACOX3(11), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(4), FADS2(4), FASN(19), HADHA(4), HSD17B12(4), PECR(1), SCD(1) 6118413 66 42 60 28 24 12 5 9 16 0 0.779 1.000 1.000 547 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(4), ACADS(4), ACADVL(1), ACSL1(3), ACSL3(7), ACSL4(4), CPT1A(9), CPT2(5), DCI(4), EHHADH(7), HADHA(4), PECR(1), SCP2(5), SLC25A20(2) 7219115 62 42 60 20 19 14 5 12 12 0 0.353 1.000 1.000 548 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(13), EGF(9), EGFR(15), HGS(4), RAB5A(2), TF(15), TFRC(2) 5503496 60 41 57 28 16 12 2 16 12 2 0.916 1.000 1.000 549 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(3), FUT2(1), FUT9(6), GBGT1(2), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST8SIA1(7) 4620674 49 41 47 21 23 6 2 12 6 0 0.733 1.000 1.000 550 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(4), BLVRB(1), HMOX1(5), IL10(2), IL10RA(5), IL10RB(2), IL1A(2), JAK1(12), STAT1(10), STAT3(7), STAT5A(3), TNF(3) 5236591 56 41 56 18 11 16 1 17 11 0 0.482 1.000 1.000 551 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(6), DLL1(15), FURIN(5), NOTCH1(27), PSEN1(3) 3968173 56 41 54 28 20 10 4 11 11 0 0.826 1.000 1.000 552 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4) 7488405 63 40 63 19 16 21 1 14 11 0 0.245 1.000 1.000 553 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9) 5766212 59 40 58 20 20 20 0 11 8 0 0.337 1.000 1.000 554 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(12), JAK2(13), JAK3(13), MAPK1(3), MAPK3(1), STAT3(7), TYK2(8) 5011880 57 40 56 23 12 21 0 14 9 1 0.808 1.000 1.000 555 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3) 3982377 56 39 55 20 21 16 4 10 5 0 0.419 1.000 1.000 556 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3) 3982377 56 39 55 20 21 16 4 10 5 0 0.419 1.000 1.000 557 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELE(5), SELL(4) 5201509 60 39 56 29 22 14 1 13 10 0 0.770 1.000 1.000 558 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(6), CCNA2(1), CCND1(1), CCNE1(5), CCNE2(3), CDK2(3), CDKN2A(13), E2F1(3), E2F2(4), PRB1(6) 3847275 45 39 45 17 9 15 1 9 10 1 0.663 1.000 1.000 559 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(11), CHAT(4), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(6), PEMT(1), SLC18A3(13) 2990888 47 38 47 26 18 10 0 14 5 0 0.914 1.000 1.000 560 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CAMKK1(5), CAMKK2(2), CREB1(3), SYT1(4) 4950394 51 38 50 21 15 19 4 7 6 0 0.599 1.000 1.000 561 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(19), GNAS(27), GNB1(1), GNGT1(3), PRKACA(4), PRKAR1A(3) 2861889 57 38 54 24 28 10 0 11 8 0 0.865 1.000 1.000 562 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(8), PSMD14(1), RPN1(3), RPN2(6), UBE2A(1), UBE3A(5) 5531848 57 38 56 21 15 17 6 10 9 0 0.541 1.000 1.000 563 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(1), RANBP2(33), RANGAP1(11) 3622899 46 37 46 20 6 15 3 11 9 2 0.863 1.000 1.000 564 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(6), HLA-DRA(8), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2RA(3), IL4(1), IL4R(3) 5432805 56 37 56 23 15 13 3 12 13 0 0.739 1.000 1.000 565 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(6), HDAC9(8), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(7), YWHAH(3) 3317406 44 36 43 17 18 7 4 6 9 0 0.589 1.000 1.000 566 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(6), CTH(2), GGT1(6), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), PAPSS1(6), PAPSS2(5), SCLY(2), SEPHS1(4) 5307074 49 36 47 23 16 10 2 8 13 0 0.819 1.000 1.000 567 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(8) 4493030 48 36 48 23 10 16 2 10 9 1 0.936 1.000 1.000 568 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(8) 4493030 48 36 48 23 10 16 2 10 9 1 0.936 1.000 1.000 569 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(10), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(4), KNG1(9), NOS3(10), REN(3) 4226077 45 35 42 18 13 9 3 6 13 1 0.739 1.000 1.000 570 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), NAT1(2), NAT2(5), XDH(14) 3428046 44 35 44 16 11 14 1 13 5 0 0.570 1.000 1.000 571 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(9), AFMID(3), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1) 5751981 49 35 48 21 19 17 2 4 7 0 0.587 1.000 1.000 572 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(16), ITGAM(9), ITGB2(6), SELE(5), SELL(4) 4455983 47 35 46 30 18 10 1 8 10 0 0.985 1.000 1.000 573 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), RFK(1), TYR(9) 4164477 47 35 43 14 7 14 3 9 14 0 0.448 1.000 1.000 574 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(9), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1) 5492669 46 34 45 21 17 16 2 4 7 0 0.696 1.000 1.000 575 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(6), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), HSD3B7(6), PON1(2), PON2(3), PON3(2), RDH11(1), RDH12(3), RDH13(5) 3863797 44 34 43 21 15 12 2 9 5 1 0.866 1.000 1.000 576 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(5), ATF3(1), CYR61(1), DUSP14(3), EIF4E(2), EIF4EBP1(2), HBEGF(1), IFNG(2), IFRD1(8), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(5), WDR1(2) 4571364 48 34 45 17 17 6 5 10 10 0 0.597 1.000 1.000 577 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(9), CS(3), FH(3), IDH2(4), MDH1(3), OGDH(11), SDHA(6), SUCLA2(4) 4045241 43 34 40 17 14 10 2 4 11 2 0.763 1.000 1.000 578 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(5), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(4), CSNK1A1(3), CSNK1D(2), GSK3B(5), MAPT(7), PPP2CA(2) 3947928 43 34 42 24 15 14 0 7 6 1 0.940 1.000 1.000 579 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(5), CDO1(1), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MPST(2), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(3), SULT4A1(2) 5375393 47 33 47 21 17 15 1 8 6 0 0.775 1.000 1.000 580 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(6), MMP2(6), MMP9(17), RECK(8), TIMP2(2), TIMP3(6), TIMP4(1) 3229191 46 33 45 21 18 11 0 4 12 1 0.798 1.000 1.000 581 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL16(13), IL18(1), IL1A(2), IL3(1), IL4(1), IL8(2), LTA(4), TNF(3) 4262673 41 32 41 20 8 11 2 11 9 0 0.927 1.000 1.000 582 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(8), BCL2(3), CASP3(2), CASP9(3), DAXX(10), FAS(3), FASLG(3), HSPB2(1), IL1A(2), MAPKAPK2(1), MAPKAPK3(5), TNF(3) 4861076 47 32 46 23 16 9 0 12 9 1 0.924 1.000 1.000 583 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(5), IMPDH1(5), MTHFD2(1), POLB(4), POLD1(15), POLG(8), PRPS2(3), RRM1(5), SRM(1) 5356739 52 32 52 19 16 16 2 10 8 0 0.567 1.000 1.000 584 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(4), EGR1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(4), RAF1(10) 3504293 43 31 38 19 14 12 0 9 8 0 0.724 1.000 1.000 585 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(3), B3GALT2(7), B3GALT5(1), B3GNT5(10), FUT1(3), FUT2(1), FUT3(3), ST3GAL3(2), ST3GAL4(6) 3103013 37 31 34 15 16 5 0 4 12 0 0.852 1.000 1.000 586 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(6), IFNGR2(2), JAK1(12), JAK2(13), STAT1(10) 3519636 45 31 45 17 6 16 2 10 10 1 0.774 1.000 1.000 587 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(4), GNB1(1), GNGT1(3), HTR2C(6), PLCB1(18), TUB(5) 3071122 41 31 40 19 12 8 1 10 10 0 0.890 1.000 1.000 588 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), FPGS(4), GCH1(1), GGH(3), SPR(2) 2800342 36 30 35 17 21 4 0 6 5 0 0.585 1.000 1.000 589 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(7), HDC(8), PNMT(8), TH(3), TPH1(3) 2587177 35 30 34 17 15 7 2 6 4 1 0.815 1.000 1.000 590 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(10), LARS(5), LARS2(7), PDHA1(1), PDHA2(6), PDHB(4) 4295125 38 30 38 18 6 13 1 10 8 0 0.920 1.000 1.000 591 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(9), CKM(1), EIF4E(2), FBL(5), GPT(3), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(7) 3852606 36 29 35 15 7 9 0 12 8 0 0.907 1.000 1.000 592 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(7), HADH(3), HADHA(4), HSD17B4(6), NTAN1(5), SIRT1(6), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(3) 5090453 45 28 42 13 12 11 4 5 13 0 0.313 1.000 1.000 593 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(3), ENO3(4), FARS2(7), GOT1(3), GOT2(2), PAH(5), TAT(5), YARS(6) 3566422 38 28 38 13 12 12 0 9 5 0 0.506 1.000 1.000 594 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(4), PTGS1(12), PTGS2(7) 2297060 34 27 34 13 12 9 1 5 7 0 0.654 1.000 1.000 595 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(11), NR0B2(3), NR1H3(6), NR1H4(5), RXRA(6) 2341435 34 27 32 15 16 4 0 6 8 0 0.713 1.000 1.000 596 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(7), FARSA(3), FARSB(1), GOT1(3), GOT2(2), PAH(5), TAT(5), YARS(6), YARS2(2) 3735417 34 27 34 14 10 12 0 8 4 0 0.768 1.000 1.000 597 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(3), MDH1(3), ME1(2), PC(15), PDHA1(1), SLC25A1(2), SLC25A11(2) 3977681 37 27 36 15 13 9 2 5 8 0 0.742 1.000 1.000 598 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(6), TAX1BP3(2), UBE2A(1), UBE2D3(2), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(6), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(1), UBE3A(5) 4508860 37 27 37 16 17 10 0 4 6 0 0.571 1.000 1.000 599 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(5), CYP11B2(5), CYP17A1(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3) 2971693 34 26 34 15 11 6 5 7 5 0 0.755 1.000 1.000 600 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(5), ACAT2(4), BDH1(5), HMGCS1(2), HMGCS2(3), OXCT1(8), OXCT2(3) 3087523 30 26 30 13 8 8 1 7 5 1 0.842 1.000 1.000 601 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(12), GOT1(3), GOT2(2), TAT(5), TYR(9) 2020580 31 26 25 11 5 8 1 8 9 0 0.811 1.000 1.000 602 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(8) 2559650 30 25 30 12 16 3 1 6 3 1 0.489 1.000 1.000 603 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1E(8), PER1(4) 3629150 33 24 32 15 10 7 2 6 7 1 0.895 1.000 1.000 604 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(6), EPHX2(4), HSD3B7(6), RDH11(1), RDH12(3), RDH13(5) 2060797 25 22 24 12 8 8 1 5 3 0 0.812 1.000 1.000 605 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(4), PRKCA(5), TGM2(12) 2138229 26 22 26 10 14 3 0 5 4 0 0.533 1.000 1.000 606 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(6), CDC25B(4), CDKN1A(3), CHEK1(4), NEK1(4), WEE1(4) 2941216 25 22 25 10 5 9 0 6 5 0 0.852 1.000 1.000 607 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(3), FUT1(3), FUT2(1), FUT9(6), GCNT2(2), ST8SIA1(7) 2635353 23 21 22 10 9 3 1 8 2 0 0.731 1.000 1.000 608 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), KARS(5) 2983556 25 21 25 10 5 10 1 6 3 0 0.705 1.000 1.000 609 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(6), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), SDHD(1), UQCRC1(2) 2840593 23 19 23 11 9 6 2 4 2 0 0.725 1.000 1.000 610 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), WASF1(5), WASL(3) 3482292 24 19 24 20 6 8 1 4 5 0 0.998 1.000 1.000 611 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2) 2935234 21 17 21 11 7 8 1 2 3 0 0.859 1.000 1.000 612 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(5), BCMO1(4), RDH5(2) 1676358 17 16 17 15 6 2 0 5 4 0 0.998 1.000 1.000 613 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(3), FUT2(1), FUT3(3), FUT5(3), FUT6(4), ST3GAL3(2) 2191676 17 14 17 10 10 3 0 1 3 0 0.860 1.000 1.000 614 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(4), RAB27A(4), RAB4A(2), RAB5A(2), RAB6A(1) 1819759 16 11 16 13 5 6 0 2 3 0 0.967 1.000 1.000 615 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(3) 778402 8 7 8 6 4 3 0 1 0 0 0.917 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 218932 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000