rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	311023	11	11	11	0	3	2	1	1	4	0	0.0397	0.000328	0.202
2	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(8), FMOD(10), KERA(1), LUM(7)	1561475	27	24	27	4	12	4	1	7	3	0	0.0696	0.403	1.000
3	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(16), AOC2(6), AOC3(15), CES1(7), ESD(1)	2594728	45	32	38	8	10	11	1	7	15	1	0.206	0.450	1.000
4	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(2), HLA-DRA(8)	632681	10	10	10	2	5	3	0	0	2	0	0.340	0.473	1.000
5	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(8), GSTZ1(3), HGD(4)	953469	15	13	14	3	4	3	0	4	4	0	0.377	0.536	1.000
6	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(1)	706305	7	7	7	1	2	2	1	1	1	0	0.308	0.659	1.000
7	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(5), GRIA2(23), JUND(2), PPP1R1B(1)	1603188	33	27	33	6	7	10	1	10	5	0	0.0641	0.722	1.000
8	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	488715	3	3	3	1	0	1	1	0	1	0	0.822	0.742	1.000
9	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(2), CD80(4), HLA-DRA(8), IL10(2), IL4(1)	1318652	17	16	17	3	9	3	0	2	3	0	0.175	0.772	1.000
10	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(2), CCR3(6), HLA-DRA(8), IL3(1)	1308153	18	16	18	4	9	6	0	2	1	0	0.154	0.778	1.000
11	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(5), LIPT1(5)	652455	10	9	8	2	2	3	0	0	5	0	0.532	0.819	1.000
12	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9)	2419403	33	24	32	6	4	8	0	14	6	1	0.158	0.856	1.000
13	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(4), CSF1(2), CSF3(2), EPO(1), IL11(3), IL3(1), IL4(1), IL7(1), IL8(2)	2220344	17	17	17	1	5	5	1	3	3	0	0.0261	0.896	1.000
14	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(5), CDK2(3), CUL1(22), E2F1(3), RB1(13), RBX1(1), SKP2(5), TFDP1(5), UBE2M(1)	3687047	58	41	56	10	11	21	2	10	14	0	0.0122	0.898	1.000
15	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(4), CD28(2), CD3E(2), CD3G(1)	992068	9	9	9	2	1	4	1	0	3	0	0.530	0.917	1.000
16	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), TFDP1(5)	2829330	53	39	51	10	13	17	2	9	12	0	0.0211	0.922	1.000
17	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(1), ALDOB(6), ALDOC(5), TPI1(1)	1682865	19	19	19	4	3	7	1	6	2	0	0.255	0.937	1.000
18	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP19(10), SRP54(6), SRP68(5), SRP72(10), SRP9(1), SRPR(12)	3233319	47	35	47	7	14	14	1	7	11	0	0.0308	0.943	1.000
19	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(9), IDI1(2), SQLE(5)	1363502	18	13	17	3	4	4	1	3	6	0	0.191	0.944	1.000
20	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(5), IL8(2), SLPI(3)	735928	10	9	9	4	3	2	0	2	3	0	0.764	0.955	1.000
21	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(26), AKT1(3), ATM(38), BAX(6), CDKN1A(3), CPB2(10), CSNK1A1(3), CSNK1D(2), FHL2(4), HIC1(6), HIF1A(7), HSPA1A(2), IGFBP3(6), MAPK8(6), MDM2(5), NFKBIB(6), NQO1(3)	8554171	136	74	124	27	31	30	5	23	42	5	0.0230	0.955	1.000
22	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(9), GBA3(2), GGT1(6), SHMT1(4), SHMT2(9)	2348712	32	29	29	7	11	4	1	4	11	1	0.212	0.962	1.000
23	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD2(3), CD34(4), CD3E(2), CD3G(1), CD58(6), CD8A(4), CSF3(2), IL3(1), IL8(2), KITLG(3)	2261536	28	22	27	6	4	9	2	4	9	0	0.172	0.966	1.000
24	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(5), CCL2(1), CSF1(2), LDLR(11), LPL(7)	2287815	26	24	26	7	10	4	1	5	5	1	0.212	0.968	1.000
25	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(4)	907276	9	9	9	2	5	0	0	2	2	0	0.459	0.974	1.000
26	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(3), GALT(1), TGDS(4), UGDH(5), UXS1(4)	1650101	17	16	17	4	6	6	1	3	1	0	0.229	0.975	1.000
27	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(6), SHMT1(4), SHMT2(9)	1767088	21	21	18	7	7	1	0	2	10	1	0.654	0.981	1.000
28	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(10)	870608	10	6	10	3	3	3	0	4	0	0	0.564	0.983	1.000
29	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(7), NR3C1(6), PPARG(4), RXRA(6), TNF(3)	2484079	29	27	27	7	7	2	4	8	8	0	0.344	0.984	1.000
30	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(2), FOS(1), FYN(10), JUN(4), MAPK14(1), THBS1(16)	3182545	36	29	35	7	10	11	1	8	5	1	0.0773	0.988	1.000
31	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), EHHADH(7), GCDH(8), HADHA(4), SDHB(4), SDS(4)	3350753	40	29	37	7	9	15	2	3	10	1	0.0439	0.989	1.000
32	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(6), HLA-DRA(8), IL1B(3), IL4(1), IL5RA(4)	1905414	23	19	23	6	9	6	0	4	4	0	0.241	0.992	1.000
33	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(2), IL12A(2), IL12B(2), IL18(1)	1274062	11	10	10	4	1	3	1	4	2	0	0.816	0.993	1.000
34	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(3), GALT(1), TGDS(4), UGDH(5), UGP2(7), UXS1(4)	2102519	24	21	22	5	8	6	1	4	5	0	0.223	0.995	1.000
35	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(9), GGPS1(1), IDI1(2), IDI2(1), SQLE(5)	1827582	20	14	19	4	4	5	1	3	7	0	0.286	0.995	1.000
36	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(5), SPCS1(3), SPCS3(2)	1319135	13	11	13	5	3	1	0	8	1	0	0.761	0.998	1.000
37	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(5), ACAT2(4), OXCT1(8)	1450639	17	16	17	7	2	8	0	3	3	1	0.859	0.998	1.000
38	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(8), CBS(6), CTH(2), MUT(6)	2096137	25	22	24	9	6	4	1	2	11	1	0.790	0.999	1.000
39	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(3), CASP9(3), CHUK(4), GH1(2), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3R1(11), PPP2CA(2), RELA(5), YWHAH(3)	5104423	52	34	51	9	8	15	3	12	13	1	0.0488	0.999	1.000
40	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), SKP2(5), TFDP1(5)	3668575	64	46	62	15	13	25	2	12	12	0	0.0421	1.000	1.000
41	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(6), ERBB4(47), NRG2(8), NRG3(17), PRKCA(5), PSEN1(3)	3865364	86	60	81	23	22	22	8	20	13	1	0.177	1.000	1.000
42	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(8), GLS2(7), GLUD1(2), GLUD2(11)	1951070	28	21	28	7	7	8	0	11	2	0	0.287	1.000	1.000
43	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(3), DFFA(4), DFFB(3), GZMB(3), HMGB2(4), TOP2A(5), TOP2B(10)	3795203	34	25	33	5	5	10	1	8	10	0	0.158	1.000	1.000
44	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(3), FOS(1), JUN(4), KEAP1(10), MAFF(1), MAPK1(3), MAPK14(1), MAPK8(6), NFE2L2(1), PRKCA(5)	3802548	35	28	35	9	10	13	2	3	6	1	0.131	1.000	1.000
45	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(2), IL1B(3), MST1(7), MST1R(14), TNF(3)	2815221	30	23	30	5	10	5	0	7	8	0	0.104	1.000	1.000
46	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), MIOX(5), UGDH(5)	3647197	55	39	47	14	10	15	0	13	17	0	0.329	1.000	1.000
47	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(4), KLK2(1), NTRK1(10), PIK3R1(11), PLCG1(19), PRKCA(5), SHC1(7), SOS1(7)	5743632	67	46	65	13	21	17	3	8	17	1	0.0384	1.000	1.000
48	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3E(2), CD3G(1), IFNG(2), IL2RA(3), IL4(1), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), TOB1(1), TOB2(5)	4545011	59	45	59	14	12	18	6	11	12	0	0.131	1.000	1.000
49	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(8), IFNAR1(8), IFNAR2(7), IFNB1(3), MAPK8(6), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(6)	4754183	61	46	61	14	15	19	1	10	14	2	0.0884	1.000	1.000
50	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(4), ACADS(4), ACAT1(5), HADHA(4)	2318194	19	15	18	5	6	5	0	2	5	1	0.319	1.000	1.000
51	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(1), AASS(7), KARS(5)	2025504	18	14	18	5	4	6	1	6	1	0	0.423	1.000	1.000
52	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(2), CCL2(1), CCR5(4), CXCR4(1), FOS(1), GNAQ(4), JUN(4), MAPK14(1), MAPK8(6), PLCG1(19), PRKCA(5), PTK2B(16), SYT1(4)	5936561	70	51	68	15	26	18	3	10	12	1	0.0255	1.000	1.000
53	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(13), SP1(6), SP3(3)	2854552	25	21	24	8	3	12	0	4	6	0	0.490	1.000	1.000
54	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), ACO2(9), FH(3), IDH1(2), IDH2(4), MDH1(3), SDHB(4), SUCLA2(4)	3823863	37	26	34	7	15	9	0	5	8	0	0.0769	1.000	1.000
55	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(31), GNA12(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8)	4333423	58	42	53	12	11	16	2	8	19	2	0.143	1.000	1.000
56	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(5), SNAP25(2), STX1A(3), VAMP2(2)	1400328	16	15	15	5	3	2	1	5	5	0	0.708	1.000	1.000
57	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(3), CASP3(2), CFL1(1), CFLAR(1), PDE6D(1)	1160480	8	7	8	4	2	4	0	1	1	0	0.791	1.000	1.000
58	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(3), CREBBP(40), DFFA(4), DFFB(3), GZMA(2), GZMB(3), HMGB2(4), PRF1(8), SET(5)	4536200	74	49	73	19	23	19	2	15	15	0	0.115	1.000	1.000
59	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3E(2), CD3G(1), CD80(4), CD86(6), CTLA4(3), GRB2(4), HLA-DRA(8), ICOS(2), ITK(6), LCK(4), PIK3R1(11), PTPN11(6)	4558122	59	46	57	13	17	15	2	10	14	1	0.156	1.000	1.000
60	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(5), HADH(3), HADHA(4), HADHB(5), HSD17B4(6), MECR(4), PPT1(6), PPT2(4)	3636190	37	24	36	8	8	15	3	4	7	0	0.0448	1.000	1.000
61	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(5), ACAT1(5), ACAT2(4), EHHADH(7), HADHA(4), HADHB(5), SDS(4)	3589460	37	24	36	9	6	16	2	3	9	1	0.170	1.000	1.000
62	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	8	CCNB1(3), CDC25A(6), CDC25B(4), CSK(7), GRB2(4), PRKCA(5), PTPRA(11), SRC(3)	3538332	43	35	43	10	14	13	0	6	10	0	0.106	1.000	1.000
63	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(2), EPO(1), FLT3(10), IGF1(4), IL11(3), IL1A(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(8)	3560367	44	33	43	10	12	11	1	12	8	0	0.136	1.000	1.000
64	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(12), PDXK(3), PDXP(1), PSAT1(5)	2075630	21	16	21	9	2	7	0	7	4	1	0.773	1.000	1.000
65	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(7), HADHA(4), SDS(4)	2082074	16	13	15	5	4	5	1	2	4	0	0.418	1.000	1.000
66	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(3), GRB2(4), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), NTRK1(10), PIK3R1(11), PLCG1(19), RPS6KA1(9), SHC1(7)	7178204	94	57	91	19	31	26	6	10	20	1	0.00860	1.000	1.000
67	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(5)	1128324	10	10	10	7	4	3	0	2	1	0	0.925	1.000	1.000
68	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	5671490	81	49	72	19	14	20	0	23	23	1	0.178	1.000	1.000
69	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(40), EP300(21), ESR1(9), MAPK1(3), MAPK3(1), PELP1(6), SRC(3)	6296008	83	54	81	19	31	22	2	13	14	1	0.0249	1.000	1.000
70	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(5), MAPK14(1), MAPK8(6), NFKB1(7), RELA(5), TNFRSF13B(5), TNFRSF13C(4), TNFRSF17(1), TNFSF13B(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6)	6232278	57	44	57	11	12	16	2	10	15	2	0.0711	1.000	1.000
71	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(5), CCND1(1), CDK2(3), CDKN1A(3), CFL1(1), E2F1(3), E2F2(4), MDM2(5), NXT1(2), PRB1(6)	3015642	33	26	32	8	8	12	1	4	7	1	0.235	1.000	1.000
72	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), INSR(14), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SLC2A4(4), SOS1(7), SRF(2)	10000033	132	71	124	29	35	32	3	19	40	3	0.0171	1.000	1.000
73	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(8), ARHGAP5(18), ARHGDIB(1), CASP1(4), CASP10(6), CASP3(2), CASP9(3), GZMB(3), JUN(4), PRF1(8)	5030725	57	41	49	12	11	10	3	11	21	1	0.313	1.000	1.000
74	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(12), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(3), APOBEC3F(2), APOBEC3G(2), APOBEC4(1)	3143328	27	20	27	6	9	6	3	5	4	0	0.241	1.000	1.000
75	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(9), NDUFS2(5), NDUFV1(5)	2969101	34	26	33	7	6	8	1	8	11	0	0.418	1.000	1.000
76	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(2), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11)	2599369	36	28	35	10	13	9	0	9	5	0	0.226	1.000	1.000
77	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCS(2), UPB1(4)	5982354	70	45	67	14	13	18	3	19	17	0	0.0217	1.000	1.000
78	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(1), COQ6(3), COQ7(3), NDUFA12(2), NDUFA13(3), NDUFB11(2)	1713010	19	17	19	8	7	5	1	3	3	0	0.773	1.000	1.000
79	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(8), ACO2(9), ACSS1(12), ACSS2(10), FH(3), IDH1(2), IDH2(4), MDH1(3), SUCLA2(4)	5715576	64	41	60	14	22	13	3	10	16	0	0.0685	1.000	1.000
80	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	8	CCNB1(3), CCNH(2), CDC25A(6), CDC25B(4), MNAT1(3), SHH(4), XPO1(7)	3272546	29	18	29	8	7	10	1	7	4	0	0.311	1.000	1.000
81	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(10), SNCA(1), SNCAIP(13), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	2761315	41	32	40	14	11	12	1	8	8	1	0.422	1.000	1.000
82	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(4), FOS(1), JUN(4), MAPK3(1), OPRK1(14), POLR2A(19), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5533905	77	54	72	19	20	24	2	15	16	0	0.0612	1.000	1.000
83	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(26), ABCB11(9), ABCB4(24), ABCC1(15), ABCC3(11), GSTP1(1)	6158288	86	59	83	22	21	20	4	18	20	3	0.120	1.000	1.000
84	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(4), PAPSS1(6), PAPSS2(5), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3)	2625444	28	23	28	7	11	10	0	3	4	0	0.289	1.000	1.000
85	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	3425297	56	35	48	19	12	13	0	11	20	0	0.726	1.000	1.000
86	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	3425297	56	35	48	19	12	13	0	11	20	0	0.726	1.000	1.000
87	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(23), CPT1A(9), LEP(2), LEPR(13), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5)	6213129	79	48	77	17	21	15	3	21	17	2	0.124	1.000	1.000
88	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(14), F2(9), F2R(3), FGA(9), FGB(4), FGG(3), PLAT(7), PLAU(7), PLG(14), SERPINB2(8), SERPINE1(3)	5760920	91	58	83	26	27	13	7	24	20	0	0.292	1.000	1.000
89	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), DIABLO(1)	5257789	49	35	43	10	13	14	0	10	12	0	0.184	1.000	1.000
90	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(43), CREBBP(40), EP300(21), MAP2K1(5), MAP3K7(10), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14)	10290478	157	88	151	34	39	43	5	26	35	9	0.0181	1.000	1.000
91	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), JUN(4), KLK2(1), MAP2K1(5), MAPK3(1), MAPK8(6), NGFR(4), PIK3R1(11), PLCG1(19), RAF1(10), SHC1(7), SOS1(7)	7265976	89	56	84	21	28	21	3	17	18	2	0.0541	1.000	1.000
92	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(16), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(6), HSD17B7(3), HSD3B1(4), HSD3B2(3)	3473806	45	37	45	14	8	14	3	13	7	0	0.300	1.000	1.000
93	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(19), PRKCA(5), PTK2B(16)	2899870	45	37	44	12	22	8	2	4	9	0	0.199	1.000	1.000
94	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(11), BMPR1A(5), BMPR1B(7), BMPR2(16)	2689015	39	33	36	10	9	8	2	4	14	2	0.469	1.000	1.000
95	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(8), GRB2(4), ILK(8), ITGB1(10), MAPK1(3), MAPK3(1), PDPK1(2), PIK3R1(11), PTK2(11), SHC1(7), SOS1(7)	6969290	75	47	70	15	20	17	4	11	21	2	0.0526	1.000	1.000
96	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(3), GLS(8), GLUD1(2), OAT(2)	2367269	19	16	19	7	5	4	0	6	4	0	0.665	1.000	1.000
97	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(5), BRAF(16), CAMP(2), CREB1(3), CREB3(7), CREB5(5), MAPK1(3), RAF1(10), SNX13(7), SRC(3), TERF2IP(5)	4797663	70	47	64	18	18	15	1	17	19	0	0.279	1.000	1.000
98	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(27), CR2(22), FCGR2B(1), HLA-DRA(8), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19)	6527237	105	65	92	29	26	32	0	23	24	0	0.183	1.000	1.000
99	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CSF1(2), CSF3(2), HLA-DRA(8), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(2), IL12B(2), IL13(2), IL1A(2), IL3(1), IL4(1), IL7(1), IL8(2), LTA(4), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3)	5328049	62	46	62	18	18	17	2	14	11	0	0.249	1.000	1.000
100	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(38), CDC25A(6), CDC25B(4), CDK2(3), CHEK1(4), MYT1(19), RB1(13), WEE1(4), YWHAH(3)	6778483	94	62	87	21	18	26	4	20	23	3	0.156	1.000	1.000
101	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), ESRRA(2), HDAC5(11), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PPARA(4), PPP3CA(10), PPP3CB(6), PPP3CC(5), SLC2A4(4), SYT1(4), YWHAH(3)	8662424	104	70	101	27	32	24	6	21	21	0	0.0712	1.000	1.000
102	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(6), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), ILVBL(5), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCDC(1), PPCS(2), UPB1(4), VNN1(4)	7431209	86	51	83	17	22	20	3	23	18	0	0.00994	1.000	1.000
103	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), CASP3(2), CASP6(1), CASP7(3), CASP9(3), EIF2S1(2), PRKCA(5), PTK2(11), PXN(4), STAT1(10), TLN1(22)	11394930	126	71	115	28	35	32	9	17	30	3	0.0405	1.000	1.000
104	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(8), ATM(38), BAX(6), BCL2(3), CCND1(1), CCNE1(5), CDK2(3), CDKN1A(3), E2F1(3), MDM2(5), PCNA(2), RB1(13), TIMP3(6)	7424035	96	59	83	22	18	25	3	17	29	4	0.263	1.000	1.000
105	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPX1(1), PRKCE(14)	3377064	74	50	73	27	18	15	8	26	7	0	0.514	1.000	1.000
106	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(4), DNAJC3(3), EIF2S1(2), EIF2S2(2), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5)	3842638	29	20	29	7	7	8	0	8	6	0	0.342	1.000	1.000
107	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), CDO1(1), CSAD(8), GAD1(7), GAD2(9), GGT1(6)	2466206	35	29	34	12	17	5	1	8	4	0	0.382	1.000	1.000
108	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(4), CHST11(4), CHST12(5), CHST13(4), PAPSS1(6), PAPSS2(5), SULT1A1(6), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3)	3956462	47	34	46	13	22	12	1	8	4	0	0.152	1.000	1.000
109	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(38), CDC25A(6), CDC25B(4), CHEK1(4), MYT1(19), WEE1(4), YWHAH(3)	5492608	78	55	72	21	18	19	3	17	18	3	0.401	1.000	1.000
110	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(4), DAB1(9), FYN(10), LRP8(5), RELN(47), VLDLR(6)	6019362	83	54	82	24	23	30	3	16	11	0	0.0869	1.000	1.000
111	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(43), AXIN1(9), CCND1(1), CD14(2), CTNNB1(22), DVL1(7), FZD1(10), GJA1(11), GNAI1(1), GSK3B(5), IRAK1(6), LBP(1), LEF1(8), LY96(4), MYD88(4), NFKB1(7), PDPK1(2), PIK3R1(11), PPP2CA(2), RELA(5), TIRAP(1), TLR4(21), TOLLIP(5), WNT1(8)	12240489	199	108	185	47	39	46	6	45	52	11	0.0304	1.000	1.000
112	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AGPS(2), CHPT1(3), ENPP2(9), ENPP6(6), PAFAH1B1(12), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4)	9818237	134	65	129	26	40	38	4	25	27	0	0.00238	1.000	1.000
113	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(6), CDKN1A(3), EPO(1), EPOR(3), GRIN1(8), HIF1A(7), JAK2(13), NFKB1(7), NFKBIA(1), RELA(5), SOD2(1)	5428608	55	37	54	14	8	17	2	10	17	1	0.285	1.000	1.000
114	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12)	2142388	40	33	38	13	18	11	1	5	5	0	0.270	1.000	1.000
115	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12)	2142388	40	33	38	13	18	11	1	5	5	0	0.270	1.000	1.000
116	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(7), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(7)	2426528	36	33	35	13	18	4	2	8	4	0	0.535	1.000	1.000
117	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(4), HBXIP(1), PTK2B(16), SHC1(7), SOS1(7), SRC(3)	3796620	41	29	41	11	13	10	0	8	10	0	0.346	1.000	1.000
118	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(3), BAK1(4), BAX(6), BCL10(2), BCL2(3), BCL2L11(1), BID(2), CASP8AP2(10), CASP9(3), CES1(7)	4675335	49	30	44	14	15	14	1	9	9	1	0.396	1.000	1.000
119	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(13), AP2A1(9), AP2M1(7), BIN1(4), CALM1(2), CALM2(2), DNM1(5), EPN1(5), EPS15(2), PICALM(2), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYNJ1(10), SYNJ2(17), SYT1(4)	9305231	103	65	95	24	27	21	3	24	28	0	0.0536	1.000	1.000
120	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(15), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF5(6), GSK3B(5), PPP1CA(2)	4952517	51	40	51	13	10	15	1	14	11	0	0.262	1.000	1.000
121	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3)	7112853	87	55	85	23	27	22	3	17	17	1	0.176	1.000	1.000
122	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(3), ALAS2(12), CPO(5), FECH(6), GATA1(3), HBB(2), HMBS(3), UROD(1), UROS(4)	3377482	43	34	43	11	10	11	3	12	7	0	0.303	1.000	1.000
123	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(4), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), GHR(6), IRS1(24), MAPK1(3), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3R1(11), PRKCA(5), RPS6KB1(5)	10790254	127	72	121	27	31	33	5	21	34	3	0.0466	1.000	1.000
124	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(11), MBTPS1(12), MBTPS2(4), SCAP(12), SREBF1(12), SREBF2(11)	5077584	64	45	61	18	22	15	1	11	14	1	0.233	1.000	1.000
125	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), EHHADH(7), HADHA(4), SDS(4)	5216751	71	39	62	24	16	18	0	13	24	0	0.627	1.000	1.000
126	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(8), CXCR4(1), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PTK2B(16), PXN(4), RAF1(10), RELA(5)	10890758	125	71	119	29	38	24	5	22	35	1	0.0354	1.000	1.000
127	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PCYT1A(9), PCYT1B(6), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6)	6030990	80	47	75	20	19	23	3	13	21	1	0.131	1.000	1.000
128	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), JUN(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(1), PLCB1(18), PRKCA(5), RAF1(10), RELA(5), TNF(3)	6678768	71	50	68	20	20	15	1	20	15	0	0.236	1.000	1.000
129	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(16), KHK(2), LCT(22), MPI(3), PGM1(3), PYGL(8), PYGM(14), TPI1(1), TREH(3)	5752710	72	52	72	21	32	18	2	8	12	0	0.161	1.000	1.000
130	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(8), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), PRF1(8), SCAP(12), SREBF1(12), SREBF2(11)	7274561	84	56	79	19	26	19	2	17	19	1	0.124	1.000	1.000
131	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), IDI1(2), LSS(9), MVD(2), NQO1(3), NQO2(3), PMVK(1), SC5DL(4), SQLE(5), VKORC1(1)	4376286	54	33	51	16	15	13	1	13	12	0	0.311	1.000	1.000
132	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(2), THTPA(2), TPK1(6)	2754764	34	26	34	10	9	11	1	5	8	0	0.327	1.000	1.000
133	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(4), GCK(4), GFPT1(4), GNE(7), GNPDA1(4), GNPDA2(6), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), PGM3(11), RENBP(2), UAP1(5)	7274408	91	59	91	24	28	27	5	16	15	0	0.0670	1.000	1.000
134	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(3), ASL(6), CPS1(22), GLS(8), GLUD1(2), GOT1(3)	3350542	44	38	44	13	14	10	2	14	4	0	0.346	1.000	1.000
135	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(6), ELK1(3), EPO(1), EPOR(3), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PLCG1(19), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14)	9231320	111	61	105	28	30	32	3	22	22	2	0.0870	1.000	1.000
136	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(5), GSS(3), IL8(2), NFKB1(7), NOX1(6), RELA(5), TNF(3), XDH(14)	4262484	46	31	46	14	7	16	2	11	10	0	0.383	1.000	1.000
137	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(1)	3747289	40	26	39	13	13	12	3	7	5	0	0.351	1.000	1.000
138	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7)	5387439	67	43	63	20	22	17	4	15	9	0	0.281	1.000	1.000
139	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(3), ALAS2(12), CPOX(2), FECH(6), HMBS(3), PPOX(5), UROD(1), UROS(4)	3258406	40	34	40	10	8	12	2	10	8	0	0.304	1.000	1.000
140	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(6), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MPL(5), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), THPO(6)	11933697	155	80	146	31	38	39	6	30	40	2	0.00968	1.000	1.000
141	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(3), BAX(6), BCL2(3), FADD(1), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), NFKB1(7), NSMAF(9), RAF1(10), RELA(5), RIPK1(2), SMPD1(8), TNFRSF1A(6), TRADD(2), TRAF2(4)	8297031	101	58	93	26	34	21	2	13	29	2	0.110	1.000	1.000
142	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6)	3390971	45	37	44	13	20	11	1	6	7	0	0.353	1.000	1.000
143	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(6), ENO1(3), GPI(5), HK1(16), PFKL(5), PGK1(4), PKLR(7), TPI1(1)	3978561	47	37	47	15	16	14	2	11	4	0	0.263	1.000	1.000
144	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(8), IFNAR2(7), IFNB1(3), JAK1(12), STAT1(10), STAT2(10), TYK2(8)	4649991	59	41	54	19	13	15	1	10	20	0	0.660	1.000	1.000
145	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3)	10717969	133	69	130	30	36	37	4	31	23	2	0.0194	1.000	1.000
146	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(7), GALNT2(5), GALNT3(4), GALNT4(5), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), WBSCR17(25)	6199575	83	57	80	24	33	14	5	15	15	1	0.346	1.000	1.000
147	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(3), CASP9(3), CDC42(1), CHUK(4), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3R1(11), RAF1(10), RALBP1(8), RALGDS(14), RELA(5)	7080019	78	48	74	21	23	22	2	12	18	1	0.139	1.000	1.000
148	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(5), GOSR1(2), GOSR2(2), SEC22B(1), SNAP25(2), SNAP29(1), STX10(3), STX11(7), STX12(2), STX16(8), STX17(2), STX18(2), STX19(3), STX2(6), STX3(2), STX4(4), STX5(1), STX6(7), STX7(2), STX8(5), TSNARE1(7), USE1(3), VAMP2(2), VAMP4(1), VAMP5(1), VAMP7(5), VTI1A(3), VTI1B(3), YKT6(1)	7168770	95	54	91	23	35	23	2	16	18	1	0.0940	1.000	1.000
149	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(43), AXIN1(9), BTRC(9), CCND1(1), CREBBP(40), CSNK1A1(3), CSNK1D(2), CSNK2A1(6), CTBP1(3), CTNNB1(22), DVL1(7), FZD1(10), GSK3B(5), HDAC1(5), MAP3K7(10), MYC(5), PPARD(8), PPP2CA(2), TLE1(9), WIF1(2), WNT1(8)	12204299	209	106	193	52	61	43	6	33	57	9	0.0494	1.000	1.000
150	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(6), ASPH(6), COPS5(3), CREB1(3), EDN1(3), EP300(21), EPO(1), HIF1A(7), JUN(4), LDHA(3), NOS3(10), P4HB(3), VHL(2)	7285971	72	46	68	19	17	17	5	13	19	1	0.238	1.000	1.000
151	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(6), PSMC3(8), PSMD1(6), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(14), PSMD6(2)	6859759	78	46	77	18	22	23	5	15	13	0	0.0755	1.000	1.000
152	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(6)	7719621	82	52	77	20	20	20	2	20	20	0	0.182	1.000	1.000
153	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(6), CYSLTR2(1), GPR109B(3), GPR161(12), GPR171(2), GPR18(2), GPR39(9), GPR45(12), GPR65(2), GPR68(3), GPR75(5), GPR81(3)	4226763	60	42	55	21	24	8	4	10	13	1	0.494	1.000	1.000
154	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	IL18(1), ITGB1(10), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), LAT(3), MAP2K1(5), MAPK3(1), PAK1(5), PIK3R1(11), PTK2B(16), PTPN6(4), SYK(7), VAV1(9)	6626596	81	59	76	23	19	24	0	19	18	1	0.290	1.000	1.000
155	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(5), ACOX3(11), FADS2(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6)	4222162	54	41	52	18	23	10	3	14	4	0	0.423	1.000	1.000
156	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(8), DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), HMGCS1(2), IDI1(2), LSS(9), MVD(2), NSDHL(3), PMVK(1), SC4MOL(4), SC5DL(4), SQLE(5)	5286772	64	40	61	20	16	14	2	15	17	0	0.435	1.000	1.000
157	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(8), AKT1(3), ANXA1(2), CALM1(2), CALM2(2), GNAS(27), GNB1(1), GNGT1(3), NFKB1(7), NOS3(10), NPPA(2), NR3C1(6), PIK3R1(11), RELA(5), SYT1(4)	6765194	93	63	86	23	34	21	0	18	19	1	0.151	1.000	1.000
158	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), MTHFR(9), PRDX6(2), SHMT1(4), SHMT2(9), TPO(24)	4968930	81	60	78	23	28	10	4	18	19	2	0.315	1.000	1.000
159	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(7), SHMT1(4)	6417659	89	57	82	25	25	21	4	17	21	1	0.305	1.000	1.000
160	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4)	6005714	82	54	75	24	22	19	3	17	20	1	0.438	1.000	1.000
161	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4)	6005714	82	54	75	24	22	19	3	17	20	1	0.438	1.000	1.000
162	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(4)	6005714	82	54	75	24	22	19	3	17	20	1	0.438	1.000	1.000
163	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NFKB1(7), PIK3R1(11), RB1(13), RELA(5), SP1(6)	7383016	77	53	72	20	13	27	1	12	23	1	0.187	1.000	1.000
164	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(7), NFKBIA(1), PLCB1(18), PRKCA(5), RELA(5)	3539135	40	33	39	14	11	8	0	10	11	0	0.642	1.000	1.000
165	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), ARHGAP5(18), BAD(3), BCAR1(8), BCL2(3), BIRC2(3), BIRC3(6), BRAF(16), CAPN2(8), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(6), COL11A1(35), COL11A2(16), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), COMP(3), CRKL(1), CTNNB1(22), DIAPH1(11), DOCK1(17), EGF(9), EGFR(15), ELK1(3), ERBB2(15), FARP2(4), FIGF(4), FLNA(26), FLNB(32), FLNC(26), FLT1(16), FN1(31), FYN(10), GRB2(4), GRLF1(15), GSK3B(5), HGF(15), IBSP(2), IGF1(4), IGF1R(16), ILK(8), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), JUN(4), KDR(13), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), MAP2K1(5), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MET(8), MYL2(8), MYL7(1), MYL9(2), MYLK(32), MYLK2(4), MYLPF(1), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PARVA(2), PARVB(4), PARVG(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(15), PDGFRB(14), PDPK1(2), PGF(2), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PRKCA(5), PRKCG(17), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF1(10), RELN(47), ROCK1(18), ROCK2(12), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SPP1(4), SRC(3), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TLN1(22), TLN2(27), TNC(23), TNN(22), TNR(22), TNXB(44), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCL(6), VEGFB(1), VEGFC(9), VTN(8), VWF(28), ZYX(7)	157862481	2116	246	2016	777	672	491	73	444	408	28	0.651	1.000	1.000
166	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY7(15), ADCY8(31), ADCY9(13), ADORA2A(1), ADORA2B(1), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), ATP2A1(16), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), ATP2B4(8), AVPR1A(14), AVPR1B(3), BDKRB1(2), BDKRB2(4), BST1(3), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1F(11), CACNA1G(23), CACNA1H(26), CACNA1I(17), CACNA1S(18), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CCKAR(5), CCKBR(9), CD38(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM5(2), CHRNA7(4), CYSLTR1(6), CYSLTR2(1), DRD1(3), EDNRA(4), EGFR(15), ERBB2(15), ERBB4(47), F2R(3), GNA11(6), GNA14(4), GNA15(3), GNAL(3), GNAQ(4), GNAS(27), GRIN1(8), GRIN2A(16), GRIN2C(6), GRIN2D(6), GRM1(31), GRM5(26), GRPR(7), HRH1(5), HRH2(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), LHCGR(11), LTB4R2(4), MYLK(32), MYLK2(4), NOS1(28), NOS3(10), NTSR1(7), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), PDE1A(7), PDE1B(6), PDE1C(11), PDGFRA(15), PDGFRB(14), PHKA1(10), PHKA2(10), PHKB(7), PHKG1(2), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PPID(3), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTAFR(5), PTGER3(5), PTGFR(5), PTK2B(16), RYR1(61), RYR2(82), RYR3(69), SLC25A4(2), SLC25A5(3), SLC25A6(5), SLC8A1(15), SLC8A2(13), SLC8A3(9), SPHK1(6), SPHK2(3), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), TNNC1(3), TRHR(5), TRPC1(8), VDAC1(3), VDAC2(1), VDAC3(3)	113564038	1787	238	1706	628	669	418	76	346	267	11	0.0353	1.000	1.000
167	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(7), ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA2A(7), ADRA2B(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), C5AR1(5), CALCR(6), CALCRL(8), CCKAR(5), CCKBR(9), CGA(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CNR1(11), CRHR1(11), CRHR2(4), CTSG(3), CYSLTR1(6), CYSLTR2(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2(9), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), FSHB(1), GABBR1(15), GABBR2(11), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GABRB1(8), GABRB2(5), GABRB3(11), GABRD(7), GABRE(7), GABRG1(4), GABRG2(13), GABRG3(6), GABRP(4), GABRQ(12), GABRR1(6), GABRR2(7), GALR1(6), GALR2(10), GALR3(2), GH1(2), GH2(1), GHR(6), GHRHR(4), GHSR(9), GIPR(3), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(5), GLRA3(6), GLRB(8), GNRHR(4), GPR156(5), GPR35(4), GPR50(11), GPR63(2), GPR83(5), GRIA1(21), GRIA2(23), GRIA3(8), GRIA4(10), GRID1(24), GRID2(16), GRIK1(11), GRIK2(18), GRIK3(16), GRIK4(14), GRIK5(10), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), GRIN3A(18), GRIN3B(6), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM6(10), GRM7(20), GRM8(22), GRPR(7), GZMA(2), HCRTR1(6), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HRH4(3), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LEP(2), LEPR(13), LHB(1), LHCGR(11), LTB4R(2), LTB4R2(4), MAS1(2), MC2R(2), MC3R(9), MC4R(5), MC5R(5), MCHR1(6), MCHR2(4), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPBWR1(13), NPBWR2(8), NPFFR1(1), NPFFR2(10), NPY1R(4), NPY2R(6), NPY5R(4), NR3C1(6), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(4), P2RY14(4), P2RY2(5), P2RY4(5), P2RY6(8), P2RY8(7), PARD3(11), PPYR1(7), PRL(1), PRLHR(7), PRLR(4), PRSS1(1), PRSS3(3), PTAFR(5), PTGDR(7), PTGER2(5), PTGER3(5), PTGER4(8), PTGFR(5), PTH2R(8), RXFP1(8), RXFP2(10), SCTR(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SSTR5(4), TAAR1(4), TAAR2(3), TAAR5(6), TAAR6(7), TAAR9(1), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), THRA(6), THRB(9), TRHR(5), TRPV1(8), TSHB(3), TSHR(10), TSPO(1), UTS2R(3), VIPR1(3), VIPR2(3)	94202734	1627	226	1576	559	604	365	69	393	193	3	0.00201	1.000	1.000
168	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(6), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), APC(43), APC2(15), ARAF(12), ARHGEF1(11), ARHGEF12(14), ARHGEF4(8), ARHGEF6(13), ARHGEF7(8), ARPC1A(3), ARPC2(3), ARPC4(2), ARPC5L(1), BAIAP2(5), BCAR1(8), BDKRB1(2), BDKRB2(4), BRAF(16), CD14(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CRKL(1), CSK(7), CYFIP1(12), CYFIP2(15), DIAPH1(11), DIAPH2(7), DIAPH3(13), DOCK1(17), EGF(9), EGFR(15), EZR(6), F2(9), F2R(3), FGD1(12), FGD3(12), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF13(12), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(3), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(7), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FN1(31), GIT1(3), GNA12(1), GNA13(5), GRLF1(15), GSN(11), IQGAP1(14), IQGAP2(10), IQGAP3(13), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(13), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LIMK1(4), LIMK2(2), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(11), MRAS(2), MSN(9), MYH10(36), MYH14(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLK(32), MYLK2(4), MYLPF(1), NCKAP1(9), NCKAP1L(14), NRAS(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDGFA(2), PDGFB(4), PDGFRA(15), PDGFRB(14), PFN2(2), PFN3(3), PFN4(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R12B(15), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RDX(7), ROCK1(18), ROCK2(12), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(10), SOS1(7), SOS2(19), SSH1(9), SSH2(22), SSH3(8), TIAM1(32), TIAM2(23), TMSL3(1), VAV1(9), VAV2(12), VAV3(10), VCL(6), WAS(3), WASF1(5), WASF2(5), WASL(3)	117128946	1574	222	1505	557	529	352	55	313	301	24	0.547	1.000	1.000
169	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1B(13), ACVR1C(5), AKT1(3), AKT2(8), AKT3(6), ARRB1(3), ARRB2(1), ATF2(3), ATF4(2), BDNF(8), BRAF(16), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1F(11), CACNA1G(23), CACNA1H(26), CACNA1I(17), CACNA1S(18), CACNA2D1(10), CACNA2D2(9), CACNA2D3(17), CACNA2D4(9), CACNB1(4), CACNB2(15), CACNB3(2), CACNB4(6), CACNG1(6), CACNG2(2), CACNG3(5), CACNG4(3), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(3), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CHUK(4), CRKL(1), DAXX(10), DDIT3(4), DUSP1(2), DUSP10(8), DUSP14(3), DUSP16(9), DUSP2(2), DUSP3(1), DUSP4(1), DUSP5(8), DUSP6(3), DUSP8(1), DUSP9(5), ECSIT(4), EGF(9), EGFR(15), ELK1(3), ELK4(1), FAS(3), FASLG(3), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF13(12), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(3), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(7), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FLNA(26), FLNB(32), FLNC(26), FOS(1), GADD45B(1), GNA12(1), GRB2(4), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), JUN(4), JUND(2), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K12(15), MAP3K13(9), MAP3K14(5), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP4K1(4), MAP4K2(7), MAP4K3(4), MAP4K4(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAPT(7), MAX(3), MEF2C(4), MKNK1(3), MKNK2(7), MOS(11), MRAS(2), MYC(5), NF1(29), NFATC2(17), NFATC4(16), NFKB1(7), NFKB2(7), NR4A1(4), NRAS(4), NTF3(5), NTRK1(10), NTRK2(13), PAK1(5), PAK2(7), PDGFA(2), PDGFB(4), PDGFRA(15), PDGFRB(14), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PPM1A(4), PPM1B(10), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PPP5C(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTPN5(6), PTPN7(7), PTPRR(12), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF2(14), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(8), RASGRP3(5), RASGRP4(4), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KA6(15), RRAS(1), RRAS2(3), SOS1(7), SOS2(19), SRF(2), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(22), TAOK3(11), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF1A(6), TRAF2(4), TRAF6(6), ZAK(8)	120991946	1663	221	1588	524	569	380	64	295	340	15	0.00212	1.000	1.000
170	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(8), ACTG1(1), CHAD(6), COL11A1(35), COL11A2(16), COL17A1(9), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), COMP(3), DES(1), DSC1(2), DSC2(12), DSC3(4), DSG1(5), DSG2(6), DSG3(10), DSG4(8), FN1(31), GJA1(11), GJA10(3), GJA3(2), GJA4(4), GJA5(8), GJA8(8), GJA9(3), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(2), GJC1(3), GJC2(3), GJD2(5), GJD4(6), IBSP(2), INA(7), ITGA6(6), ITGB4(18), KRT1(6), KRT10(6), KRT12(3), KRT13(9), KRT14(2), KRT15(3), KRT16(8), KRT17(5), KRT18(2), KRT19(1), KRT2(10), KRT20(4), KRT23(11), KRT24(6), KRT25(7), KRT27(8), KRT28(10), KRT3(8), KRT31(6), KRT32(7), KRT33A(9), KRT33B(4), KRT34(6), KRT35(4), KRT36(6), KRT37(3), KRT38(4), KRT39(8), KRT4(7), KRT40(1), KRT5(3), KRT6A(9), KRT6B(3), KRT6C(7), KRT7(3), KRT71(2), KRT72(7), KRT73(15), KRT74(4), KRT75(6), KRT76(4), KRT77(2), KRT78(3), KRT79(5), KRT8(6), KRT81(3), KRT82(2), KRT83(3), KRT84(6), KRT85(3), KRT86(3), KRT9(1), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), LMNA(6), LMNB1(4), LMNB2(6), NES(12), PRPH(3), RELN(47), SPP1(4), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(23), TNN(22), TNR(22), TNXB(44), VIM(10), VTN(8), VWF(28)	107036911	1415	219	1381	588	443	330	56	330	241	15	0.995	1.000	1.000
171	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(19), ATP1B1(2), ATP1B2(3), ATP1B3(3), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(34), CACNA1E(43), CACNA1S(18), CACNB1(4), CACNB3(2), CALM1(2), CALM2(2), CALR(5), CAMK1(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), GJA1(11), GJA4(4), GJA5(8), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAZ(18), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNG7(4), GNGT1(3), GRK4(4), GRK5(1), GRK6(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNB1(12), KCNJ3(16), KCNJ5(5), MIB1(4), NME7(1), PKIA(2), PKIG(2), PLCB3(12), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RYR1(61), RYR2(82), RYR3(69), SFN(1), SLC8A1(15), SLC8A3(9), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2)	80368364	1239	214	1201	449	458	293	55	246	176	11	0.124	1.000	1.000
172	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(15), CD36(2), CD44(5), CHAD(6), COL11A1(35), COL11A2(16), COL1A1(11), COL1A2(30), COL2A1(17), COL3A1(11), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(28), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(40), COL6A6(34), DAG1(13), FN1(31), FNDC1(15), FNDC3A(8), FNDC4(2), FNDC5(2), GP5(7), GP6(3), GP9(3), HMMR(7), HSPG2(35), IBSP(2), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LAMA1(45), LAMA2(34), LAMA3(24), LAMA4(26), LAMA5(28), LAMB1(17), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), RELN(47), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SPP1(4), SV2A(13), SV2B(5), SV2C(9), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(23), TNN(22), TNR(22), TNXB(44), VTN(8), VWF(28)	96226801	1273	212	1227	501	403	276	45	300	231	18	0.935	1.000	1.000
173	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), AMOTL1(8), ASH1L(39), CASK(7), CDC42(1), CGN(13), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CSDA(5), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTTN(7), EPB41(11), EPB41L1(6), EPB41L2(9), EPB41L3(27), EXOC3(3), EXOC4(8), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), HCLS1(3), IGSF5(3), INADL(16), JAM2(2), JAM3(8), LLGL1(9), LLGL2(6), MAGI1(18), MAGI2(30), MAGI3(9), MLLT4(24), MPDZ(23), MPP5(1), MRAS(2), MYH1(20), MYH10(36), MYH11(29), MYH13(24), MYH14(18), MYH15(17), MYH2(29), MYH3(27), MYH4(22), MYH6(27), MYH7(23), MYH7B(23), MYH8(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLPF(1), NRAS(4), OCLN(6), PARD3(11), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP2R3A(9), PPP2R3B(14), PPP2R4(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), RAB13(2), RAB3B(3), RRAS(1), RRAS2(3), SPTAN1(20), SRC(3), SYMPK(7), TJAP1(2), TJP1(21), TJP2(15), TJP3(11), VAPA(3), YES1(2), ZAK(8)	82619342	1162	208	1122	367	386	271	40	265	191	9	0.0468	1.000	1.000
174	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(7), ABLIM1(12), ABLIM2(11), ABLIM3(6), ARHGEF12(14), CDC42(1), CDK5(2), CFL1(1), CFL2(1), CXCR4(1), DCC(32), DPYSL2(2), DPYSL5(10), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(4), EFNB1(1), EFNB2(3), EFNB3(7), EPHA1(13), EPHA2(25), EPHA3(22), EPHA4(17), EPHA5(28), EPHA6(27), EPHA7(6), EPHA8(13), EPHB1(23), EPHB2(12), EPHB3(12), EPHB4(9), EPHB6(14), FES(11), FYN(10), GNAI1(1), GNAI2(3), GNAI3(7), GSK3B(5), ITGB1(10), L1CAM(16), LIMK1(4), LIMK2(2), LRRC4C(5), MAPK1(3), MAPK3(1), MET(8), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NGEF(6), NRAS(4), NRP1(14), NTN1(7), NTN4(2), NTNG1(19), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PLXNA1(32), PLXNA2(26), PLXNA3(19), PLXNB1(19), PLXNB2(17), PLXNB3(12), PLXNC1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PTK2(11), RAC2(2), RAC3(4), RASA1(17), RGS3(13), RHOD(2), RND1(3), ROBO1(30), ROBO2(33), ROBO3(11), ROCK1(18), ROCK2(12), SEMA3A(15), SEMA3B(4), SEMA3C(7), SEMA3D(12), SEMA3E(12), SEMA3F(10), SEMA3G(5), SEMA4A(9), SEMA4B(9), SEMA4C(10), SEMA4D(15), SEMA4F(8), SEMA4G(4), SEMA5A(24), SEMA5B(20), SEMA6A(18), SEMA6B(5), SEMA6C(10), SEMA6D(20), SEMA7A(7), SLIT1(10), SLIT2(27), SLIT3(14), SRGAP1(12), SRGAP2(7), SRGAP3(13), UNC5A(10), UNC5B(10), UNC5C(16), UNC5D(16)	84133628	1281	207	1240	437	404	275	73	284	232	13	0.273	1.000	1.000
175	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	124	ALCAM(10), CADM3(11), CD2(3), CD22(5), CD226(2), CD274(2), CD276(6), CD28(2), CD34(4), CD40(3), CD40LG(5), CD58(6), CD6(9), CD80(4), CD86(6), CD8A(4), CD8B(1), CD99(1), CDH15(6), CDH2(18), CDH3(10), CDH4(21), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CNTN1(19), CNTN2(10), CNTNAP1(18), CNTNAP2(40), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-C(13), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-G(5), ICAM1(2), ICAM2(3), ICAM3(1), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(6), ITGA8(6), ITGA9(8), ITGAL(16), ITGAM(9), ITGAV(13), ITGB1(10), ITGB2(6), ITGB7(6), ITGB8(14), JAM2(2), JAM3(8), L1CAM(16), MAG(14), MPZ(2), MPZL1(2), NCAM1(4), NCAM2(24), NEGR1(7), NEO1(14), NFASC(18), NLGN1(16), NLGN2(10), NLGN3(13), NRCAM(11), NRXN1(43), NRXN2(28), NRXN3(28), OCLN(6), PDCD1(2), PDCD1LG2(1), PTPRC(19), PTPRF(18), PTPRM(28), PVR(3), PVRL1(1), PVRL2(5), PVRL3(6), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SELE(5), SELL(4), SELP(10), SELPLG(7), SIGLEC1(18), SPN(4), VCAM1(10), VCAN(41)	60907695	948	200	910	342	304	243	31	208	154	8	0.164	1.000	1.000
176	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(43), APC2(15), AXIN1(9), AXIN2(15), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(19), CREBBP(40), CSNK1A1(3), CSNK1A1L(6), CSNK1E(8), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTBP1(3), CTBP2(8), CTNNB1(22), CTNNBIP1(1), CUL1(22), CXXC4(2), DAAM1(11), DAAM2(13), DKK1(9), DKK2(5), DKK4(3), DVL1(7), DVL2(6), DVL3(12), EP300(21), FBXW11(10), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LEF1(8), LRP5(22), LRP6(7), MAP3K7(10), MAPK10(5), MAPK8(6), MAPK9(3), MMP7(2), MYC(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKD1(10), NKD2(1), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PORCN(5), PPARD(8), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRICKLE1(16), PRICKLE2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PSEN1(3), RAC2(2), RAC3(4), RBX1(1), ROCK1(18), ROCK2(12), RUVBL1(9), SENP2(4), SFRP1(4), SFRP2(6), SFRP4(6), SFRP5(1), SIAH1(2), SMAD2(9), SMAD3(5), SOX17(11), TBL1X(6), TBL1XR1(5), TBL1Y(1), TCF7(9), TCF7L1(5), TCF7L2(11), VANGL1(2), VANGL2(9), WIF1(2), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4)	67539649	1037	198	987	310	366	243	27	173	213	15	0.000965	1.000	1.000
177	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(6), ACTN2(23), ACTN3(4), ACTN4(11), DES(1), DMD(62), FAM48A(10), MYBPC1(7), MYBPC2(10), MYBPC3(6), MYH3(27), MYH6(27), MYH7(23), MYH8(18), MYL1(1), MYL2(8), MYL3(3), MYL9(2), MYOM1(12), NEB(63), TMOD1(4), TNNI1(2), TNNI2(6), TNNT1(5), TNNT2(2), TNNT3(2), TPM1(4), TPM3(3), TPM4(3), TTN(512), VIM(10)	58405619	880	195	862	262	225	233	50	279	77	16	0.0102	1.000	1.000
178	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(5), ACVR1B(13), ACVR2A(8), ACVR2B(5), AMHR2(4), BMP2(5), BMP7(7), BMPR1A(5), BMPR1B(7), BMPR2(16), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(2), CCL2(1), CCL20(2), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL3(1), CCL5(2), CCL7(1), CCL8(2), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CD27(2), CD40(3), CD40LG(5), CD70(2), CLCF1(2), CNTF(3), CNTFR(3), CSF1(2), CSF1R(15), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), CX3CL1(7), CX3CR1(3), CXCL10(1), CXCL16(3), CXCL2(2), CXCL9(2), CXCR3(1), CXCR4(1), CXCR6(2), EDA(1), EDA2R(3), EDAR(8), EGF(9), EGFR(15), EPO(1), EPOR(3), FAS(3), FASLG(3), FLT1(16), FLT3(10), FLT3LG(1), FLT4(24), GDF5(11), GH1(2), GH2(1), GHR(6), HGF(15), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL13(2), IL13RA1(4), IL15RA(3), IL17B(4), IL17RA(7), IL17RB(6), IL18(1), IL18R1(3), IL18RAP(2), IL19(1), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL1RAP(7), IL20(1), IL20RA(8), IL21(4), IL21R(10), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL28A(1), IL28B(5), IL28RA(2), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL8(2), IL9R(3), INHBA(12), INHBB(10), INHBC(6), INHBE(2), KDR(13), KIT(12), KITLG(3), LEP(2), LEPR(13), LIF(2), LIFR(13), LTA(4), LTBR(2), MET(8), MPL(5), NGFR(4), OSM(5), OSMR(8), PDGFB(4), PDGFC(7), PDGFRA(15), PDGFRB(14), PF4V1(1), PLEKHO2(3), PRL(1), PRLR(4), RELT(6), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(3), TNFRSF13B(5), TNFRSF13C(4), TNFRSF14(1), TNFRSF17(1), TNFRSF19(9), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFRSF4(3), TNFRSF8(4), TNFRSF9(11), TNFSF10(5), TNFSF11(4), TNFSF13B(4), TNFSF14(3), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(24), TSLP(3), VEGFB(1), VEGFC(9), XCL1(1), XCR1(4)	76037446	963	193	925	342	279	239	40	210	187	8	0.386	1.000	1.000
179	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(3), ACTA2(6), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADM(2), ARRB1(3), ARRB2(1), ATF2(3), ATF3(1), ATF4(2), ATF5(3), ATP2A2(5), ATP2A3(6), CACNB3(2), CALCA(2), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CNN1(3), CNN2(1), CORIN(13), CREB3(7), CRHR1(11), DGKZ(8), ETS2(4), FOS(1), GABPA(2), GABPB2(3), GBA2(4), GJA1(11), GNAQ(4), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNG7(4), GNGT1(3), GRK4(4), GRK5(1), GRK6(4), GUCA2A(1), GUCA2B(1), GUCY1A3(15), IGFBP1(9), IGFBP2(5), IGFBP3(6), IGFBP4(1), IGFBP6(1), IL1B(3), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), MAFF(1), MIB1(4), MYL2(8), MYLK2(4), NFKB1(7), NOS1(28), NOS3(10), OXT(1), OXTR(7), PDE4B(5), PDE4D(4), PKIA(2), PKIG(2), PLCB3(12), PLCD1(4), PLCG1(19), PLCG2(15), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), RAMP2(2), RAMP3(3), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RLN1(3), RYR1(61), RYR2(82), RYR3(69), SFN(1), SLC8A1(15), SP1(6), TNXB(44), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2)	74207709	1043	192	1011	383	369	228	45	234	158	9	0.353	1.000	1.000
180	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCBP2(2), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CCRL1(5), CCRL2(1), CHML(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CMKLR1(4), CNR1(11), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GPR17(5), GPR173(5), GPR174(3), GPR27(5), GPR3(4), GPR35(4), GPR37(10), GPR37L1(5), GPR4(3), GPR50(11), GPR6(11), GPR63(2), GPR77(5), GPR83(5), GPR85(4), GPR87(5), GRPR(7), HCRTR1(6), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LHCGR(11), LTB4R(2), MAS1(2), MC3R(9), MC4R(5), MC5R(5), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPN1SW(1), OPN3(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OR10A5(5), OR11A1(5), OR12D3(4), OR1C1(5), OR1F1(4), OR1Q1(5), OR2H1(2), OR5V1(7), OR7C1(6), OR8B8(5), OXTR(7), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(4), P2RY14(4), P2RY2(5), P2RY6(8), PPYR1(7), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), RGR(2), RHO(7), RRH(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SUCNR1(4), TBXA2R(8), TRHR(5)	51273351	848	186	821	319	320	208	33	178	106	3	0.0693	1.000	1.000
181	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADK(4), ADSL(5), ADSS(5), ADSSL1(8), AK1(1), AK5(4), AK7(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), GART(9), GDA(4), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), IMPDH2(4), ITPA(1), NME6(3), NME7(1), NPR1(11), NPR2(8), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NUDT2(4), NUDT9(2), PAICS(1), PAPSS1(6), PAPSS2(5), PDE10A(17), PDE11A(8), PDE1A(7), PDE1C(11), PDE2A(14), PDE3B(20), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6D(1), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PDE9A(7), PFAS(9), PKLR(7), PKM2(6), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PPAT(5), PRIM1(2), PRIM2(4), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), XDH(14), ZNRD1(1)	69850220	854	181	828	296	267	218	32	180	152	5	0.384	1.000	1.000
182	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(9), EGF(9), EGFR(15), GJA1(11), GJD2(5), GNA11(6), GNAI1(1), GNAI2(3), GNAI3(7), GNAQ(4), GNAS(27), GRB2(4), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), HTR2A(6), HTR2B(5), HTR2C(6), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(11), NPR2(8), NRAS(4), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(15), PDGFRB(14), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKG1(9), PRKG2(13), PRKX(5), RAF1(10), SOS1(7), SOS2(19), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2)	56543534	852	180	828	311	287	208	34	194	124	5	0.464	1.000	1.000
183	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(8), AKT3(6), CBL(3), CBLB(3), CBLC(5), CCND1(1), CCND2(3), CCND3(2), CISH(3), CLCF1(2), CNTF(3), CNTFR(3), CREBBP(40), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), EP300(21), EPO(1), EPOR(3), GH1(2), GH2(1), GHR(6), GRB2(4), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL13(2), IL13RA1(4), IL13RA2(6), IL15RA(3), IL19(1), IL20(1), IL20RA(8), IL21(4), IL21R(10), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL28A(1), IL28B(5), IL28RA(2), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(3), IRF9(6), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), LIF(2), LIFR(13), MPL(5), MYC(5), OSM(5), OSMR(8), PIAS1(12), PIAS2(12), PIAS3(7), PIAS4(7), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIM1(2), PRL(1), PRLR(4), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(6), SOCS7(3), SOS1(7), SOS2(19), SPRED1(13), SPRED2(7), SPRY1(3), SPRY3(6), SPRY4(5), STAM(7), STAM2(5), STAT1(10), STAT2(10), STAT3(7), STAT4(6), STAT5A(3), STAT5B(14), STAT6(3), TPO(24), TSLP(3), TYK2(8)	61400168	777	174	732	241	207	195	30	162	177	6	0.150	1.000	1.000
184	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(12), BRAF(16), C7orf16(3), CACNA1A(24), CRHR1(11), GNA11(6), GNA12(1), GNA13(5), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(27), GNAZ(18), GRIA1(21), GRIA2(23), GRIA3(8), GRID2(16), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), IGF1(4), IGF1R(16), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(28), NOS3(10), NPR1(11), NPR2(8), NRAS(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PRKCA(5), PRKCG(17), PRKG1(9), PRKG2(13), RAF1(10), RYR1(61)	46960385	768	174	737	238	273	174	28	185	103	5	0.0259	1.000	1.000
185	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), AKAP1(3), AKAP10(3), AKAP11(16), AKAP12(18), AKAP3(12), AKAP4(11), AKAP5(2), AKAP6(23), AKAP7(3), AKAP8(10), AKAP9(39), ARHGEF1(11), CALM1(2), CALM2(2), CHMP1B(1), GNA11(6), GNA12(1), GNA13(5), GNA14(4), GNA15(3), GNAI2(3), GNAI3(7), GNAL(3), GNAO1(1), GNAQ(4), GNAZ(18), GNB1(1), GNB2(3), GNB3(1), GNB5(1), GNG13(2), GNG7(4), GNGT1(3), GNGT2(2), ITPR1(24), KCNJ3(16), NRAS(4), PDE1A(7), PDE1B(6), PDE1C(11), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PLCB3(12), PPP3CA(10), PPP3CC(5), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), PRKD1(20), PRKD3(5), RRAS(1), SLC9A1(10), USP5(6)	49739590	656	170	627	233	190	171	23	141	123	8	0.424	1.000	1.000
186	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACP1(5), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), ACVR1B(13), ACVR1C(5), BAIAP2(5), CDC42(1), CREBBP(40), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), EGFR(15), EP300(21), ERBB2(15), FARP2(4), FER(13), FGFR1(13), FYN(10), IGF1R(16), INSR(14), IQGAP1(14), LEF1(8), LMO7(14), MAP3K7(10), MAPK1(3), MAPK3(1), MET(8), MLLT4(24), PARD3(11), PTPN1(3), PTPN6(4), PTPRB(22), PTPRF(18), PTPRJ(27), PTPRM(28), PVRL1(1), PVRL2(5), PVRL3(6), PVRL4(7), RAC2(2), RAC3(4), SMAD2(9), SMAD3(5), SNAI1(3), SNAI2(11), SORBS1(9), SRC(3), SSX2IP(9), TCF7(9), TCF7L1(5), TCF7L2(11), TGFBR1(4), TGFBR2(14), TJP1(21), VCL(6), WAS(3), WASF1(5), WASF2(5), WASF3(13), WASL(3), YES1(2)	49675833	718	170	685	225	208	196	22	130	153	9	0.0634	1.000	1.000
187	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(23), ACACB(34), AKT1(3), AKT2(8), AKT3(6), ARAF(12), BAD(3), BRAF(16), CALM1(2), CALM2(2), CALML3(1), CBL(3), CBLB(3), CBLC(5), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(11), FASN(19), FBP1(4), FBP2(5), FLOT1(4), FLOT2(5), FOXO1(4), G6PC2(1), GCK(4), GRB2(4), GSK3B(5), GYS1(6), GYS2(6), IKBKB(7), INPP5D(4), INSR(14), IRS1(24), IRS2(6), IRS4(27), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MKNK1(3), MKNK2(7), NRAS(4), PCK1(11), PCK2(9), PDE3A(13), PDE3B(20), PDPK1(2), PFKL(5), PFKM(3), PFKP(15), PHKA1(10), PHKA2(10), PHKB(7), PHKG1(2), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PKLR(7), PKM2(6), PPARGC1A(10), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCI(8), PRKCZ(1), PRKX(5), PTPN1(3), PTPRF(18), PYGB(10), PYGL(8), PYGM(14), RAF1(10), RAPGEF1(10), RHEB(1), RPS6(1), RPS6KB1(5), RPS6KB2(4), SH2B2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(9), SOS1(7), SOS2(19), SREBF1(12), TRIP10(9), TSC1(7), TSC2(12)	66047110	855	167	812	304	282	191	25	147	201	9	0.609	1.000	1.000
188	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(7), ACTN2(23), ACTN3(4), ACTN4(11), ARHGAP5(18), BCAR1(8), CD99(1), CDC42(1), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(5), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(3), CLDN6(7), CLDN8(2), CLDN9(7), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), CXCR4(1), CYBB(8), ESAM(5), EZR(6), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), GRLF1(15), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), ITK(6), JAM2(2), JAM3(8), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(24), MMP2(6), MMP9(17), MSN(9), MYL2(8), MYL7(1), MYL9(2), MYLPF(1), NCF1(3), NCF2(4), NCF4(1), NOX1(6), NOX3(7), OCLN(6), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAC2(2), RAP1A(2), RAP1B(6), RAPGEF3(2), RAPGEF4(8), RASSF5(4), RHOH(2), ROCK1(18), ROCK2(12), SIPA1(4), THY1(1), TXK(2), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCAM1(10), VCL(6)	52183069	749	164	708	262	236	167	29	133	172	12	0.567	1.000	1.000
189	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(7), ANAPC1(12), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(3), ANAPC7(6), ATM(38), ATR(18), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC14B(4), CDC16(7), CDC20(5), CDC23(6), CDC25A(6), CDC25B(4), CDC26(1), CDC27(3), CDC6(8), CDC7(4), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), CREBBP(40), CUL1(22), DBF4(7), E2F1(3), E2F2(4), E2F3(3), EP300(21), ESPL1(15), FZR1(7), GADD45B(1), GSK3B(5), HDAC1(5), HDAC2(2), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(9), PRKDC(40), PTTG1(1), PTTG2(3), RB1(13), RBL1(11), RBL2(8), RBX1(1), SFN(1), SKP2(5), SMAD2(9), SMAD3(5), SMC1A(7), SMC1B(8), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	56189777	633	163	610	200	174	164	23	137	131	4	0.281	1.000	1.000
190	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADK(4), ADSL(5), ADSS(5), AK1(1), AK5(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), ATP1B1(2), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(2), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), GART(9), GDA(4), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), IMPDH2(4), ITPA(1), NPR1(11), NPR2(8), NT5C(1), NT5E(2), NUDT2(4), PAICS(1), PAPSS1(6), PAPSS2(5), PDE1A(7), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6B(10), PDE6C(4), PDE6G(1), PDE7B(3), PDE8A(10), PDE9A(7), PFAS(9), PKLR(7), PKM2(6), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RRM1(5), RRM2(4)	54802177	673	163	650	232	196	176	28	151	118	4	0.433	1.000	1.000
191	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(19), ADCY8(31), ARAF(12), ATF4(2), BRAF(16), CACNA1C(37), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CREBBP(40), EP300(21), GNAQ(4), GRIA1(21), GRIA2(23), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), GRM1(31), GRM5(26), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(4), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R1A(1), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF3(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15)	42454473	669	162	644	218	220	170	18	140	117	4	0.0504	1.000	1.000
192	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ATF4(2), CACNA1C(37), CACNA1D(34), CACNA1F(11), CACNA1S(18), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CDC42(1), CGA(1), EGFR(15), ELK1(3), FSHB(1), GNA11(6), GNAQ(4), GNAS(27), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(1), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), LHB(1), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(6), MAPK9(3), MMP14(6), MMP2(6), NRAS(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLD1(19), PLD2(15), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(7), PRKX(5), PTK2B(16), RAF1(10), SOS1(7), SOS2(19), SRC(3)	53966587	751	161	731	253	271	179	28	142	125	6	0.115	1.000	1.000
193	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(7), ABL2(12), AKT1(3), AKT2(8), AKT3(6), ARAF(12), BAD(3), BRAF(16), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CBL(3), CBLB(3), CBLC(5), CDKN1A(3), CRKL(1), EGF(9), EGFR(15), EIF4EBP1(2), ELK1(3), ERBB2(15), ERBB4(47), EREG(2), GAB1(3), GRB2(4), GSK3B(5), HBEGF(1), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(9), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK9(3), MYC(5), NCK1(6), NCK2(5), NRAS(4), NRG1(14), NRG2(8), NRG3(17), NRG4(2), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), RAF1(10), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SRC(3), STAT5A(3), STAT5B(14), TGFA(2)	41543809	592	160	555	191	183	138	27	112	127	5	0.227	1.000	1.000
194	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(6), BCAR1(8), CAPN1(5), CAPN10(7), CAPN11(6), CAPN2(8), CAPN3(10), CAPN5(9), CAPN6(7), CAPN7(8), CAPN9(4), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CSK(7), DOCK1(17), FYN(10), GIT2(2), GRB2(4), ILK(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(13), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAPK10(5), MAPK12(1), MAPK4(6), MAPK6(1), MAPK7(6), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PDPK1(2), PIK3R2(12), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(10), RHO(7), ROCK1(18), ROCK2(12), SDCCAG8(5), SHC1(7), SHC3(10), SORBS1(9), SOS1(7), SRC(3), TLN1(22), TNS1(27), VASP(2), VAV2(12), VAV3(10), VCL(6), ZYX(7)	57422581	677	158	651	238	219	153	29	127	137	12	0.488	1.000	1.000
195	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(13), ACVRL1(5), AKT1(3), AURKB(5), BMPR1A(5), BMPR2(16), BUB1(12), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(6), CDS2(2), CLK1(4), CLK2(11), CLK4(4), COL4A3BP(5), CSNK2A1(6), CSNK2A2(6), CSNK2B(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MAP3K10(8), MOS(11), NEK1(4), NEK3(3), OCRL(9), PAK4(8), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PIM2(3), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15), PLK3(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKCZ(1), PRKD1(20), PRKG1(9), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KB1(5), STK11(3), TGFBR1(4), VRK1(1)	47406894	627	158	593	184	180	146	25	129	140	7	0.109	1.000	1.000
196	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM2(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(2), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5D(4), INPP5E(6), INPPL1(24), ITGB1BP3(2), ITPK1(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), OCRL(9), PI4KA(15), PI4KB(5), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PRKCA(5), PRKCG(17), PTPMT1(1), SYNJ1(10), SYNJ2(17)	52075445	639	156	603	197	210	151	20	119	131	8	0.0819	1.000	1.000
197	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(15), ADCY8(31), ADCY9(13), ASIP(2), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CREB1(3), CREB3(7), CREB3L1(4), CREB3L2(4), CREB3L3(4), CREB3L4(2), CREBBP(40), CTNNB1(22), DCT(13), DVL1(7), DVL2(6), DVL3(12), EDN1(3), EP300(21), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(27), GSK3B(5), KIT(12), KITLG(3), LEF1(8), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MITF(10), NRAS(4), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), POMC(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), TCF7(9), TCF7L1(5), TCF7L2(11), TYR(9), TYRP1(4), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4)	45852713	729	156	697	259	272	180	20	133	121	3	0.116	1.000	1.000
198	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(20), BDKRB1(2), BDKRB2(4), C1QA(5), C1QB(1), C1QC(2), C1R(5), C1S(7), C2(2), C3(29), C3AR1(8), C4BPA(3), C4BPB(3), C5(11), C5AR1(5), C6(12), C7(3), C8A(5), C8B(14), C9(7), CD46(3), CD55(3), CFB(7), CFH(21), CFI(13), CPB2(10), CR1(27), CR2(22), F10(7), F11(3), F12(3), F13A1(14), F13B(16), F2(9), F2R(3), F3(1), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), KNG1(9), MASP1(1), MASP2(6), MBL2(4), PLAT(7), PLAU(7), PLAUR(4), PLG(14), PROC(3), PROS1(9), SERPINA1(7), SERPINA5(7), SERPINC1(4), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(7), TFPI(4), THBD(1), VWF(28)	38840565	533	153	499	148	140	128	25	124	114	2	0.0296	1.000	1.000
199	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(5), ACVR1B(13), ACVR1C(5), ACVR2A(8), ACVR2B(5), ACVRL1(5), AMHR2(4), BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BMPR1A(5), BMPR1B(7), BMPR2(16), CHRD(9), COMP(3), CREBBP(40), CUL1(22), DCN(8), E2F5(1), EP300(21), FST(4), GDF5(11), GDF6(15), GDF7(4), ID1(1), ID3(1), IFNG(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), LEFTY1(4), LTBP1(19), MAPK1(3), MAPK3(1), MYC(5), NOG(1), PITX2(6), PPP2CA(2), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), RBL1(11), RBL2(8), RBX1(1), ROCK1(18), ROCK2(12), RPS6KB1(5), RPS6KB2(4), SMAD1(4), SMAD2(9), SMAD3(5), SMAD5(2), SMAD6(5), SMAD7(5), SMAD9(8), SMURF1(5), SMURF2(5), SP1(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNF(3), ZFYVE16(11), ZFYVE9(8)	41763099	598	152	577	204	191	143	27	101	127	9	0.288	1.000	1.000
200	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(7), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGEF6(13), ARHGEF7(8), BCAR1(8), BRAF(16), CAV1(4), CDC42(1), CSE1L(5), DOCK1(17), EPHB2(12), FYN(10), GRB2(4), GRB7(6), GRLF1(15), ILK(8), ITGA1(8), ITGA10(9), ITGA11(12), ITGA2(10), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGB3BP(1), MAP2K4(9), MAP3K11(10), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MRAS(2), MYLK(32), MYLK2(4), P4HB(3), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PKLR(7), PLCG1(19), PLCG2(15), PTK2(11), RAF1(10), RHO(7), ROCK1(18), ROCK2(12), SHC1(7), SOS1(7), SOS2(19), SRC(3), TERF2IP(5), TLN1(22), TLN2(27), VASP(2), WAS(3), ZYX(7)	50636122	626	152	597	205	206	136	21	111	140	12	0.364	1.000	1.000
201	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(17), ABCA10(19), ABCA12(31), ABCA13(52), ABCA2(18), ABCA3(17), ABCA4(17), ABCA5(24), ABCA6(16), ABCA7(13), ABCA8(13), ABCA9(16), ABCB1(26), ABCB10(12), ABCB11(9), ABCB4(24), ABCB5(16), ABCB6(9), ABCB7(4), ABCB8(8), ABCB9(4), ABCC1(15), ABCC10(10), ABCC11(16), ABCC12(17), ABCC2(12), ABCC3(11), ABCC4(18), ABCC5(11), ABCC6(14), ABCC8(17), ABCC9(34), ABCD1(6), ABCD2(4), ABCD3(5), ABCD4(8), ABCG1(10), ABCG2(6), ABCG4(4), ABCG5(2), ABCG8(5), CFTR(14), TAP1(4), TAP2(13)	50558397	621	150	588	200	173	167	23	127	120	11	0.0882	1.000	1.000
202	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT1(3), AKT2(8), AKT3(6), BCL10(2), CARD11(20), CBL(3), CBLB(3), CBLC(5), CD247(3), CD28(2), CD3E(2), CD3G(1), CD40LG(5), CD8A(4), CD8B(1), CDC42(1), CHUK(4), CTLA4(3), FOS(1), FYN(10), GRAP2(4), GRB2(4), ICOS(2), IFNG(2), IKBKB(7), IL10(2), IL4(1), ITK(6), JUN(4), LAT(3), LCK(4), LCP2(7), MALT1(4), MAP3K14(5), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKCQ(10), PTPN6(4), PTPRC(19), RASGRP1(8), SOS1(7), SOS2(19), TEC(4), TNF(3), VAV1(9), VAV2(12), VAV3(10), ZAP70(14)	41851337	538	149	517	174	173	130	19	102	111	3	0.183	1.000	1.000
203	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	76	ABL1(7), ATM(38), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDAN1(12), CDC14B(4), CDC20(5), CDC25A(6), CDC25B(4), CDC6(8), CDC7(4), CDK2(3), CDKN1A(3), CHEK1(4), CHEK2(8), DTX4(7), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), EP300(21), ESPL1(15), GSK3B(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(11), HDAC6(7), HDAC8(3), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MPEG1(10), MPL(5), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(9), PRKDC(40), PTPRA(11), PTTG1(1), PTTG2(3), RB1(13), RBL1(11), SKP2(5), TBC1D8(9), TFDP1(5), TGFB1(3), WEE1(4)	44349286	522	148	501	165	144	133	23	114	104	4	0.256	1.000	1.000
204	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(39), ASH2L(5), C17orf79(2), CARM1(5), CTCFL(11), DOT1L(11), EED(5), EHMT1(14), EHMT2(12), EZH1(5), EZH2(6), FBXO11(11), HCFC1(17), HSF4(7), JMJD4(1), JMJD6(3), KDM6A(12), MEN1(8), MLL(36), MLL2(90), MLL3(71), MLL4(30), MLL5(20), NSD1(24), OGT(5), PAXIP1(5), PPP1CA(2), PPP1CB(1), PPP1CC(5), PRDM2(30), PRDM7(2), PRDM9(18), PRMT1(7), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), RBBP5(3), SATB1(16), SETD1A(18), SETD2(18), SETD7(2), SETDB1(18), SETDB2(10), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(5), SUV39H2(2), SUV420H1(11), SUV420H2(3), SUZ12(3), WHSC1(16), WHSC1L1(17)	50987438	696	147	640	190	180	165	20	111	187	33	0.105	1.000	1.000
205	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(3), AKT2(8), AKT3(6), BAD(3), CDC42(1), CDK2(3), CREB1(3), CREB3(7), CREB5(5), EBP(1), ERBB4(47), F2RL2(3), GAB1(3), GRB2(4), GSK3A(3), GSK3B(5), IFI27(1), IGF1(4), IGFBP1(9), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), MET(8), MYC(5), NOLC1(9), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PPP1R13B(11), PREX1(16), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SLC2A4(4), SOS1(7), SOS2(19), TSC1(7), TSC2(12), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	31657728	430	147	404	123	136	94	19	76	101	4	0.0501	1.000	1.000
206	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(12), BID(2), BRAF(16), CASP3(2), CD244(2), CD247(3), CD48(1), FAS(3), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(10), GRB2(4), GZMB(3), HCST(1), HLA-C(13), HLA-E(5), HLA-G(5), ICAM1(2), ICAM2(3), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), ITGAL(16), ITGB2(6), KIR2DL1(4), KIR2DL3(2), KIR2DL4(3), KIR3DL1(7), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), LAT(3), LCK(4), LCP2(7), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICB(3), NCR1(3), NCR2(3), NCR3(1), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NRAS(4), PAK1(5), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRF1(8), PRKCA(5), PRKCG(17), PTK2B(16), PTPN11(6), PTPN6(4), RAC2(2), RAC3(4), RAF1(10), SH2D1A(1), SH2D1B(1), SH3BP2(5), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SYK(7), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFSF10(5), TYROBP(2), ULBP1(3), ULBP3(1), VAV1(9), VAV2(12), VAV3(10), ZAP70(14)	46954797	652	146	619	197	194	155	17	129	154	3	0.0279	1.000	1.000
207	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(3), AKT2(8), AKT3(6), CCL3(1), CCL5(2), CD14(2), CD40(3), CD80(4), CD86(6), CHUK(4), CXCL10(1), CXCL9(2), FADD(1), FOS(1), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(7), IFNB1(3), IKBKB(7), IKBKE(12), IL12A(2), IL12B(2), IL1B(3), IL8(2), IRAK1(6), IRAK4(3), IRF3(3), IRF5(4), IRF7(1), JUN(4), LBP(1), LY96(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K7(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MYD88(4), NFKB1(7), NFKB2(7), NFKBIA(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), RELA(5), RIPK1(2), SPP1(4), STAT1(10), TBK1(8), TICAM1(8), TIRAP(1), TLR1(6), TLR2(2), TLR3(6), TLR4(21), TLR5(10), TLR6(3), TLR7(5), TLR8(14), TLR9(16), TNF(3), TOLLIP(5), TRAF3(4), TRAF6(6)	36746377	440	145	418	151	117	101	16	99	104	3	0.586	1.000	1.000
208	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(1), ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG6(2), ALG8(4), ALG9(2), B3GNT1(3), B3GNT2(3), B3GNT6(4), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT5(6), B4GALT7(5), C1GALT1(3), C1GALT1C1(7), CHPF(2), CHST1(14), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST2(14), CHST3(3), CHST4(6), CHST6(11), CHST7(7), CHSY1(6), DPAGT1(4), EXT1(19), EXT2(6), EXTL1(8), EXTL2(2), EXTL3(10), FUT11(3), FUT8(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL1(11), GALNTL2(10), GALNTL4(12), GALNTL5(3), GANAB(11), GCNT3(3), GCNT4(4), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), MGAT5B(5), NDST1(11), NDST2(9), NDST3(13), NDST4(12), OGT(5), RPN1(3), RPN2(6), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST6GALNAC1(4), STT3B(5), UST(9), WBSCR17(25), XYLT1(12)	46223254	615	144	588	228	204	141	20	117	126	7	0.875	1.000	1.000
209	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(16), AMY2A(3), AMY2B(14), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(6), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENPP1(7), ENPP3(8), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), G6PC2(1), GAA(5), GANC(9), GBA(9), GBA3(2), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), IFIH1(8), LYZL1(5), MGAM(15), MOV10L1(6), PGM1(3), PGM3(11), PYGB(10), PYGL(8), PYGM(14), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SI(27), SKIV2L2(8), SMARCA2(22), SMARCA5(7), TREH(3), UGDH(5), UGP2(7), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UXS1(4)	52961020	609	143	599	188	167	165	16	132	126	3	0.168	1.000	1.000
210	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(43), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(8), CTNNB1(22), DVL1(7), DVL2(6), DVL3(12), FBXW2(3), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LDLR(11), MAPK10(5), MAPK9(3), MYC(5), PAFAH1B1(12), PLAU(7), PPP2R5C(7), PPP2R5E(5), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKCZ(1), PRKD1(20), SFRP4(6), TCF7(9), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7)	25292624	425	143	398	141	134	80	15	84	101	11	0.255	1.000	1.000
211	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(5), ALG6(2), CCKBR(9), CCR2(6), CCR3(6), CCR5(4), CELSR1(37), CELSR2(31), CELSR3(51), CHRM2(17), CHRM3(11), CIDEB(2), CXCR3(1), DRD4(3), EDNRA(4), EMR2(9), EMR3(4), F2R(3), GHRHR(4), GNRHR(4), GPR116(13), GPR132(4), GPR133(13), GPR135(8), GPR143(4), GPR17(5), GPR18(2), GPR55(7), GPR56(5), GPR61(7), GPR77(5), GPR84(2), GPR88(1), GRM1(31), GRPR(7), HRH4(3), LGR6(12), LPHN2(19), LPHN3(17), LTB4R2(4), NTSR1(7), OR2M4(5), OR8G2(5), P2RY13(4), PTGFR(5), SMO(13), SSTR2(4), TAAR5(6), TSHR(10), VN1R1(3)	27977850	444	141	432	148	145	115	22	102	56	4	0.0589	1.000	1.000
212	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(9), CD14(2), CD19(4), CD1A(10), CD1B(7), CD1C(9), CD1D(8), CD1E(7), CD2(3), CD22(5), CD33(6), CD34(4), CD36(2), CD37(3), CD38(4), CD3E(2), CD3G(1), CD44(5), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(1), CD9(1), CR1(27), CR2(22), CSF1(2), CSF1R(15), CSF2RA(9), CSF3(2), CSF3R(13), DNTT(3), EPO(1), EPOR(3), FCER2(2), FLT3(10), FLT3LG(1), GP5(7), GP9(3), GYPA(3), HLA-DRA(8), IL11(3), IL11RA(3), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL7(1), IL7R(9), IL9R(3), ITGA1(8), ITGA2(10), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(7), KIT(12), KITLG(3), MME(7), MS4A1(1), TFRC(2), THPO(6), TNF(3), TPO(24)	34601991	432	141	404	141	113	97	19	108	90	5	0.311	1.000	1.000
213	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BTRC(9), CSNK1A1(3), CSNK1A1L(6), CSNK1D(2), CSNK1E(8), CSNK1G1(6), CSNK1G2(5), CSNK1G3(8), DHH(2), FBXW11(10), GAS1(4), GLI1(20), GLI2(14), GLI3(47), GSK3B(5), HHIP(16), IHH(7), LRP2(60), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), PTCH1(23), PTCH2(10), RAB23(2), SHH(4), SMO(13), STK36(11), SUFU(5), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4), ZIC2(5)	25751704	451	138	425	137	157	95	16	87	90	6	0.0537	1.000	1.000
214	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(8), BAD(3), BCL2(3), CABIN1(15), CALM1(2), CALM2(2), CAMK2B(4), CAMK4(8), CD3E(2), CD3G(1), CD69(3), CDKN1A(3), CNR1(11), CREBBP(40), CSNK2A1(6), CSNK2B(1), CTLA4(3), EGR2(8), EGR3(6), EP300(21), FCER1A(3), FCGR3A(4), FOS(1), FOSL1(1), GATA3(17), GATA4(4), GRLF1(15), GSK3A(3), GSK3B(5), ICOS(2), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(2), IL1B(3), IL2RA(3), IL3(1), IL4(1), IL8(2), ITK(6), JUNB(3), KPNA5(6), MAPK14(1), MAPK8(6), MAPK9(3), MEF2A(2), MEF2B(5), MEF2D(7), MYF5(5), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB2(7), NFKBIB(6), NPPB(2), NUP214(22), OPRD1(2), P2RX7(1), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(5), PPP3R1(4), PTPRC(19), RELA(5), RPL13A(4), SFN(1), SLA(4), SP1(6), SP3(3), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(9), VAV2(12), VAV3(10), XPO5(4)	38827559	492	135	473	173	149	131	17	99	92	4	0.379	1.000	1.000
215	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGAP1(4), ARHGAP4(5), ARHGEF11(18), BTK(4), CDC42(1), CFL1(1), CFL2(1), GDI1(3), GDI2(4), INPPL1(24), ITPR1(24), ITPR2(30), ITPR3(36), LIMK1(4), MYLK(32), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PDK1(3), PIK3CD(11), PIK3CG(21), PIK3R1(11), PITX2(6), PPP1R13B(11), RACGAP1(7), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), SAG(4), WASF1(5), WASL(3)	28795949	384	130	356	106	127	86	17	56	89	9	0.0512	1.000	1.000
216	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(3), AKT2(8), AKT3(6), BAD(3), CASP9(3), CDC42(1), KDR(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NOS3(10), NRAS(4), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKCA(5), PRKCG(17), PTGS2(7), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), SH2D2A(7), SHC2(2), SPHK1(6), SPHK2(3), SRC(3)	29609532	397	129	378	112	137	88	14	76	80	2	0.0123	1.000	1.000
217	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(38), CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC25A(6), CDK2(3), CDKN1A(3), CDKN2D(3), CREB3(7), CREB3L1(4), CREB3L3(4), CREB3L4(2), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), GBA2(4), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MNAT1(3), MYC(5), MYT1(19), NACA(2), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(4), POLE(24), POLE2(4), PRIM1(2), RB1(13), RBL1(11), RPA1(2), RPA2(2), RPA3(2), TFDP1(5), TFDP2(4), TNXB(44), WEE1(4)	32517517	345	128	330	115	105	85	16	68	67	4	0.279	1.000	1.000
218	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), AKT1(3), AKT2(8), AKT3(6), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CAPN1(5), CAPN2(8), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CSF2RB(9), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL3(1), IL3RA(5), IRAK1(6), IRAK2(7), IRAK3(6), IRAK4(3), MAP3K14(5), MYD88(4), NFKB1(7), NFKB2(7), NFKBIA(1), NTRK1(10), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(5), TRADD(2), TRAF2(4)	33998710	413	128	384	110	120	85	12	74	114	8	0.0502	1.000	1.000
219	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(16), CPEB1(5), EGFR(15), ERBB2(15), ERBB4(47), ETS1(8), ETS2(4), ETV6(7), ETV7(5), FMN2(38), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(27), NOTCH2(25), NOTCH3(22), NOTCH4(16), PIWIL1(6), PIWIL2(8), PIWIL3(5), PIWIL4(7), RAF1(10), SOS1(7), SOS2(19), SPIRE1(7), SPIRE2(4)	22213947	336	128	313	111	103	73	12	86	58	4	0.422	1.000	1.000
220	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(3), ADCY4(9), ADCY6(14), ADCY8(31), CACNA1A(24), CACNA1B(24), GNAS(27), GNAT3(5), GNB1(1), GNB3(1), GNG13(2), GRM4(11), ITPR3(36), KCNB1(12), PDE1A(7), PLCB2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), SCNN1B(7), SCNN1G(4), TAS1R1(7), TAS1R2(10), TAS1R3(8), TAS2R1(3), TAS2R13(3), TAS2R14(5), TAS2R16(9), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(2), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(3), TAS2R9(1), TRPM5(6)	24153466	337	127	328	121	124	84	14	71	42	2	0.321	1.000	1.000
221	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(34), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADIPOQ(3), ADIPOR1(5), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(8), AKT3(6), CAMKK1(5), CAMKK2(2), CD36(2), CHUK(4), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), G6PC2(1), IKBKB(7), IRS1(24), IRS2(6), IRS4(27), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), MAPK10(5), MAPK8(6), MAPK9(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NPY(2), PCK1(11), PCK2(9), POMC(8), PPARA(4), PPARGC1A(10), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKCQ(10), PTPN11(6), RELA(5), RXRA(6), RXRB(4), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(7), STK11(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(8)	35581356	449	127	430	145	142	89	11	98	101	8	0.368	1.000	1.000
222	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(8), CLK2(11), CLK3(12), CLK4(4), COL2A1(17), CPSF1(19), CPSF2(4), CPSF3(3), CPSF4(3), CSTF1(8), CSTF2(5), CSTF2T(7), CSTF3(8), DDIT3(4), DDX1(7), DDX20(4), DHX15(10), DHX16(6), DHX38(16), DHX8(13), DHX9(7), DICER1(11), DNAJC8(4), GIPC1(4), NCBP1(5), NCBP2(3), NONO(4), NUDT21(2), NXF1(7), PABPN1(3), PAPOLA(5), PHF5A(1), POLR2A(19), PPM1G(4), PRPF18(2), PRPF3(6), PRPF4(6), PRPF4B(11), PRPF8(16), PSKH1(7), PTBP1(6), PTBP2(1), RBM17(2), RBM5(8), RNGTT(4), RNMT(9), SF3A1(3), SF3A2(2), SF3A3(3), SF3B1(7), SF3B2(17), SF3B4(5), SF4(5), SFRS12(4), SFRS14(6), SFRS16(6), SFRS4(5), SFRS5(7), SFRS6(5), SFRS7(2), SFRS8(13), SFRS9(1), SNRPA(8), SNRPA1(4), SNRPB(2), SNRPB2(2), SNRPD1(3), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(8), SPOP(3), SRPK1(3), SRPK2(8), SRRM1(12), SUPT5H(13), U2AF1(4), U2AF2(10), XRN2(14)	45433080	526	127	509	148	181	135	22	86	97	5	0.0897	1.000	1.000
223	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(3), BDKRB2(4), CALM1(2), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(5), FLT1(16), FLT4(24), KDR(13), NOS3(10), PDE2A(14), PDE3A(13), PDE3B(20), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKG1(9), PRKG2(13), RYR2(82), SLC7A1(6), SYT1(4), TNNI1(2)	17362439	284	127	275	95	85	71	9	74	45	0	0.225	1.000	1.000
224	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(3), ADAM17(6), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(2), CCL5(2), CDC42(1), CHUK(4), CSK(7), EGFR(15), F11R(2), GIT1(3), HBEGF(1), IGSF5(3), IKBKB(7), IL8(2), JAM2(2), JAM3(8), JUN(4), LYN(5), MAP2K4(9), MAP3K14(5), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(6), MAPK9(3), MET(8), NFKB1(7), NFKB2(7), NFKBIA(1), NOD1(11), PAK1(5), PLCG1(19), PLCG2(15), PTPN11(6), PTPRZ1(25), RELA(5), SRC(3), TCIRG1(7), TJP1(21)	29703045	338	124	325	117	92	78	10	81	76	1	0.608	1.000	1.000
225	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(16), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), CARM1(5), COMT(4), DBH(6), DCT(13), ECH1(1), ESCO1(7), ESCO2(8), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HEMK1(1), HGD(4), HPD(1), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), MIF(1), MYST3(28), MYST4(20), NAT6(3), PNMT(8), PNPLA3(2), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SH3GLB1(3), TAT(5), TH(3), TPO(24), TYR(9), TYRP1(4), WBSCR22(6)	25073677	350	123	325	101	97	79	9	77	82	6	0.115	1.000	1.000
226	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(3), BRAF(16), CHUK(4), CREB1(3), DAXX(10), ELK1(3), FOS(1), GRB2(4), IKBKB(7), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K11(10), MAP3K12(15), MAP3K13(9), MAP3K14(5), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP3K9(3), MAP4K1(4), MAP4K2(7), MAP4K3(4), MAP4K4(10), MAP4K5(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(6), MAPK8(6), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MKNK2(7), MYC(5), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(7), RAF1(10), RELA(5), RIPK1(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(6), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4)	40455701	430	123	417	149	129	100	20	74	103	4	0.548	1.000	1.000
227	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), BCR(11), BLNK(4), BTK(4), CD19(4), CD22(5), CD81(6), CR2(22), CSK(7), DAG1(13), FLOT1(4), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPP5D(4), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP4K1(4), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(17), NR0B2(3), PDK1(3), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PTPRC(19), RAF1(10), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9)	30816252	410	123	388	122	136	95	8	81	85	5	0.0543	1.000	1.000
228	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(8), AKT3(6), BCL10(2), BLNK(4), BTK(4), CARD11(20), CD19(4), CD22(5), CD72(2), CD79A(6), CD79B(2), CD81(6), CHUK(4), CR2(22), FCGR2B(1), FOS(1), GSK3B(5), IFITM1(1), IKBKB(7), INPP5D(4), JUN(4), LILRB3(5), LYN(5), MALT1(4), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(4), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(4), PPP3R2(4), PTPN6(4), RAC2(2), RAC3(4), RASGRP3(5), SYK(7), VAV1(9), VAV2(12), VAV3(10)	30829916	401	122	379	130	130	92	9	78	91	1	0.246	1.000	1.000
229	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3)	21655457	286	121	274	97	76	81	9	69	48	3	0.327	1.000	1.000
230	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB2C(5), TUBB3(13), TUBB4(7), TUBB4Q(4), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3)	21655457	286	121	274	97	76	81	9	69	48	3	0.327	1.000	1.000
231	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(3), AKT2(8), AKT3(6), BTK(4), FCER1A(3), FYN(10), GAB2(3), GRB2(4), IL13(2), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(7), LYN(5), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MS4A2(2), NRAS(4), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PRKCA(5), PRKCD(7), PRKCE(14), RAC2(2), RAC3(4), RAF1(10), SOS1(7), SOS2(19), SYK(7), TNF(3), VAV1(9), VAV2(12), VAV3(10)	29353214	380	118	366	116	116	94	10	77	80	3	0.141	1.000	1.000
232	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(5), CAMK1(2), CAMK1G(6), CAMK4(8), CREBBP(40), CSNK1A1(3), EDN1(3), ELSPBP1(3), F2(9), FGF2(3), FKBP1A(2), GATA4(4), GSK3B(5), HAND1(3), HAND2(2), IGF1(4), LIF(2), MAP2K1(5), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), MEF2C(4), MYH2(29), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKX2-5(4), NPPA(2), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RAF1(10), RPS6KB1(5), SYT1(4)	20830824	304	118	292	91	108	67	11	55	61	2	0.0258	1.000	1.000
233	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(6), ANKRD6(6), APC(43), AXIN1(9), AXIN2(15), CER1(2), CSNK1A1(3), CTNNB1(22), DACT1(10), DKK1(9), DKK2(5), DKK3(3), DKK4(3), DVL1(7), FSTL1(3), GSK3A(3), GSK3B(5), LRP1(47), MVP(7), NKD1(10), NKD2(1), PIN1(2), PSEN1(3), PTPRA(11), SENP2(4), SFRP1(4), TSHB(3), WIF1(2)	17297677	259	118	237	81	78	61	4	47	57	12	0.407	1.000	1.000
234	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(8), ATM(38), ATR(18), BAI1(14), BAX(6), BID(2), CASP3(2), CASP9(3), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CD82(3), CDK2(3), CDK6(4), CDKN1A(3), CHEK1(4), CHEK2(8), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(3), IGF1(4), IGFBP3(6), LRDD(6), MDM2(5), MDM4(5), PERP(3), PPM1D(9), RCHY1(1), RFWD2(7), RPRM(5), RRM2(4), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(2), SESN2(2), SESN3(4), SFN(1), SIAH1(2), STEAP3(9), THBS1(16), TNFRSF10B(2), TP53I3(1), TP73(5), TSC2(12), ZMAT3(4)	26539030	289	117	274	91	82	77	6	58	61	5	0.322	1.000	1.000
235	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(2), AGTR2(4), ATP8A1(9), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(2), EDNRA(4), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GNRHR(4), GPR77(5), GRPR(7), LHCGR(11), MC2R(2), MC3R(9), MC4R(5), MC5R(5), NMBR(4), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), PPYR1(7), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), TAC4(3), TACR1(3), TACR2(1), TACR3(15), TRHR(5), TSHR(10)	21493599	336	116	324	129	131	90	9	58	47	1	0.221	1.000	1.000
236	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(5), APC(43), ATF2(3), AXIN1(9), BMP10(4), BMP2(5), BMP4(6), BMP5(11), BMP7(7), BMPR1A(5), BMPR2(16), CHRD(9), CTNNB1(22), DVL1(7), FZD1(10), GATA4(4), GSK3B(5), MAP3K7(10), MEF2C(4), MYL2(8), NKX2-5(4), NOG(1), NPPA(2), NPPB(2), RFC1(9), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), WNT1(8)	15607883	261	115	250	76	65	62	9	47	67	11	0.224	1.000	1.000
237	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5E(6), INPPL1(24), IPMK(1), ISYNA1(4), ITGB1BP3(2), ITPK1(4), ITPKA(2), ITPKB(11), MINPP1(5), MIOX(5), OCRL(9), PI4KA(15), PI4KB(5), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(8), PTPMT1(1), SYNJ1(10), SYNJ2(17)	30553150	371	115	348	113	130	90	7	71	72	1	0.0876	1.000	1.000
238	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CHPT1(3), CRLS1(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), ESCO1(7), ESCO2(8), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(10), GPD1(7), GPD1L(3), GPD2(6), LCAT(4), LYPLA1(1), LYPLA2(2), MYST3(28), MYST4(20), NAT6(3), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(15), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(4), PTDSS2(3), SH3GLB1(3)	27922723	334	115	328	117	110	86	11	68	57	2	0.387	1.000	1.000
239	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(8), AKT3(6), ASAH1(4), BRAF(16), DAG1(13), DRD2(9), EGFR(15), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), PI3(2), PIK3CB(13), PITX2(6), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), RAF1(10), RGS20(6), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT3(7), TERF2IP(5)	25101444	355	115	339	116	121	85	11	70	63	5	0.273	1.000	1.000
240	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(3), AK3(5), CAD(18), CANT1(4), CTPS(1), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), ITPA(1), NME6(3), NME7(1), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NUDT2(4), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), TK1(1), TK2(3), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UPB1(4), UPP1(1), UPP2(7), UPRT(6), ZNRD1(1)	34589561	367	114	360	113	124	88	13	68	71	3	0.0764	1.000	1.000
241	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(8), AKT3(6), BCR(11), BTK(4), CD19(4), DAPP1(1), FLOT1(4), FLOT2(5), GAB1(3), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), NR0B2(3), PDK1(3), PHF11(4), PITX2(6), PLCG2(15), PPP1R13B(11), PREX1(16), PTPRC(19), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SAG(4), SYK(7), TEC(4), VAV1(9)	22141852	272	113	265	99	98	63	7	56	44	4	0.572	1.000	1.000
242	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AGK(6), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AKR1A1(1), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DAK(8), DGAT1(3), DGAT2(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(15), DGKQ(2), DGKZ(8), GK(3), GK2(7), GLA(3), GLB1(5), GPAM(10), LCT(22), LIPA(3), LIPC(4), LIPF(5), LIPG(4), LPL(7), MGLL(1), PNLIP(4), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4)	25140442	302	112	291	102	83	80	9	63	65	2	0.331	1.000	1.000
243	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(3), CD28(2), CSK(7), CTLA4(3), DAG1(13), EPHB2(12), GRAP2(4), GRB2(4), ITK(6), ITPKA(2), ITPKB(11), LAT(3), LCK(4), LCP2(7), MAPK1(3), NCK1(6), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PLCG1(19), PTPRC(19), RAF1(10), RASGRP1(8), RASGRP2(8), RASGRP3(5), RASGRP4(4), SOS1(7), SOS2(19), VAV1(9), ZAP70(14)	23227824	305	112	295	94	101	71	11	67	53	2	0.177	1.000	1.000
244	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(3), AKT2(8), AKT3(6), BRAF(16), CAB39(1), EIF4B(5), EIF4EBP1(2), FIGF(4), HIF1A(7), IGF1(4), MAPK1(3), MAPK3(1), PDPK1(2), PGF(2), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(12), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(7), RHEB(1), RICTOR(20), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), STK11(3), TSC1(7), TSC2(12), ULK1(16), ULK2(11), VEGFB(1), VEGFC(9)	21801263	288	111	269	86	98	58	11	50	69	2	0.275	1.000	1.000
245	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(43), AR(14), ASAH1(4), BRAF(16), CAMP(2), CCL15(2), CCL16(1), DAG1(13), EGFR(15), GNA11(6), GNA15(3), GNAI1(1), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CD(11), PIK3R1(11), PITX2(6), PTX3(2), RAF1(10), SRC(3)	21962967	315	111	299	97	101	70	14	58	59	13	0.100	1.000	1.000
246	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(7), AKT1(3), APC(43), ASAH1(4), CAMP(2), CAV3(2), DAG1(13), DLG4(3), EPHB2(12), GNAI1(1), GNAQ(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ3(16), KCNJ5(5), KCNJ9(2), MAPK1(3), PITX2(6), PTX3(2), RHO(7), RYR1(61)	19684467	286	111	278	95	104	63	9	51	46	13	0.165	1.000	1.000
247	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(7), ACTN2(23), ACTN3(4), BCAR1(8), BCR(11), CAPN1(5), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(7), FYN(10), GRB2(4), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MAPK8(6), PPP1R12B(15), PTK2(11), PXN(4), RAF1(10), RAP1A(2), ROCK1(18), SHC1(7), SOS1(7), SRC(3), TLN1(22), VCL(6), ZYX(7)	20180510	243	110	234	80	86	58	10	51	35	3	0.164	1.000	1.000
248	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(43), AXIN1(9), CREBBP(40), CTNNB1(22), DVL1(7), EP300(21), FZD1(10), GSK3B(5), HDAC1(5), LDB1(5), LEF1(8), PITX2(6), TRRAP(49), WNT1(8)	14224454	238	110	225	66	77	52	6	41	52	10	0.0606	1.000	1.000
249	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(5), APOA1(8), CD36(2), CITED2(3), CPT1B(5), CREBBP(40), DUSP1(2), DUT(2), EHHADH(7), EP300(21), HSD17B4(6), HSPA1A(2), JUN(4), LPL(7), MAPK1(3), MAPK3(1), ME1(2), MYC(5), NCOA1(17), NCOR1(26), NCOR2(30), NFKBIA(1), NR0B2(3), NR1H3(6), NR2F1(7), NRIP1(17), PDGFA(2), PIK3R1(11), PPARA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PTGS2(7), RB1(13), RELA(5), RXRA(6), SP1(6), SRA1(1), STAT5A(3), STAT5B(14), TNF(3)	26171716	343	110	330	105	89	92	9	68	82	3	0.143	1.000	1.000
250	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(3), AKT2(8), AKT3(6), BRD4(11), CAP1(5), CBL(3), CDC42(1), F2RL2(3), FLOT1(4), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), IGFBP1(9), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), LNPEP(11), MAPK1(3), MAPK3(1), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PIK3R1(11), PPYR1(7), PTPN1(3), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(4), SORBS1(9), SOS1(7), SOS2(19), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	23997415	314	110	294	92	113	68	5	49	76	3	0.119	1.000	1.000
251	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), F10(7), F11(3), F12(3), F2(9), F2R(3), F5(21), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), PROC(3), PROS1(9), SERPINC1(4), SERPING1(7)	19074452	216	108	213	69	53	56	7	62	37	1	0.226	1.000	1.000
252	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(13), AR(14), ESR1(9), ESR2(9), ESRRA(2), HNF4A(8), NR0B1(5), NR1D1(5), NR1D2(6), NR1H2(7), NR1H3(6), NR1I2(7), NR1I3(4), NR2C2(3), NR2E1(3), NR2F1(7), NR2F2(3), NR2F6(3), NR3C1(6), NR4A1(4), NR4A2(12), NR5A1(5), NR5A2(5), PGR(15), PPARA(4), PPARD(8), PPARG(4), RARA(3), RARB(7), RARG(1), ROR1(10), RORA(6), RORC(6), RXRA(6), RXRB(4), RXRG(5), THRA(6), THRB(9), VDR(2)	18034824	242	108	236	99	89	50	13	50	39	1	0.834	1.000	1.000
253	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(9), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), CDC42(1), CFL1(1), CFL2(1), FLNA(26), FLNC(26), FSCN1(5), FSCN3(11), GDI1(3), GDI2(4), LIMK1(4), MYH2(29), MYLK(32), MYLK2(4), PAK1(5), PAK2(7), PAK3(6), PAK4(8), PAK6(9), PAK7(9), PFN2(2), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), VASP(2), WASF1(5), WASL(3)	20534986	262	108	247	86	93	61	8	45	50	5	0.222	1.000	1.000
254	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(4), BAX(6), BFAR(5), BTK(4), CAD(18), CASP10(6), CASP3(2), CASP8AP2(10), CD7(5), CSNK1A1(3), DAXX(10), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(15), EPHB2(12), FADD(1), FAF1(8), FAIM2(1), IL1A(2), IL8(2), MAP2K4(9), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MET(8), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), NR0B2(3), PFN2(2), PTPN13(24), RALBP1(8), RIPK1(2), ROCK1(18), SMPD1(8), TPX2(6), TRAF2(4), TUFM(3)	30041275	322	108	309	120	92	79	8	62	76	5	0.786	1.000	1.000
255	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(16), AMY2A(3), AMY2B(14), ENPP1(7), ENPP3(8), GAA(5), GANAB(11), GBA3(2), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), MGAM(15), PGM1(3), PGM3(11), PYGB(10), PYGL(8), PYGM(14), SI(27), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4), UXS1(4)	24355756	267	108	263	87	67	80	6	57	57	0	0.299	1.000	1.000
256	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(2), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), GSN(11), LMNA(6), LMNB1(4), LMNB2(6), MAP3K1(11), MAP3K14(5), MAP3K5(5), MAPK8(6), MDM2(5), NFKB1(7), NFKBIA(1), NUMA1(25), PAK2(7), PRKCD(7), PRKDC(40), PSEN1(3), PSEN2(2), PTK2(11), RASA1(17), RB1(13), RELA(5), RIPK1(2), SPTAN1(20), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4)	28835914	302	107	294	101	87	79	15	47	71	3	0.445	1.000	1.000
257	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(5), CAD(18), CANT1(4), CTPS(1), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ITPA(1), NT5C(1), NT5E(2), NUDT2(4), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), RRM1(5), RRM2(4), TK1(1), TK2(3), TXNRD1(6), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UNG(2), UPB1(4), UPP1(1)	24438612	261	107	253	86	70	65	10	58	55	3	0.372	1.000	1.000
258	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(14), GABBR1(15), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM7(20), GRM8(22)	9011198	192	104	183	76	83	30	11	45	23	0	0.536	1.000	1.000
259	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(5), AANAT(2), ABP1(16), ACAT1(5), ACAT2(4), ACMSD(5), AFMID(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CARM1(5), CAT(5), CYP1A1(5), CYP1A2(5), CYP1B1(2), EHHADH(7), GCDH(8), HAAO(1), HADH(3), HADHA(4), HEMK1(1), HSD17B4(6), INMT(3), KMO(4), KYNU(11), LCMT1(1), LCMT2(11), LNX1(3), MAOA(2), MAOB(3), METTL6(3), NFX1(5), OGDH(11), OGDHL(16), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), TDO2(7), TPH1(3), TPH2(7), WARS(5), WARS2(10), WBSCR22(6)	25538240	319	104	291	99	79	81	12	51	90	6	0.362	1.000	1.000
260	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(6), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(6), QDPR(3), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SKIV2L2(8), SMARCA2(22), SMARCA5(7), SPR(2)	26941169	324	104	318	110	115	70	8	66	63	2	0.486	1.000	1.000
261	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCR(11), BLNK(4), BTK(4), CD19(4), CSK(7), DAG1(13), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PI3(2), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), RAF1(10), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9)	21686339	268	104	256	92	88	61	5	56	56	2	0.506	1.000	1.000
262	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADH(3), HADHA(4), HSD17B4(6), HSD3B7(6), NSD1(24), OGDH(11), OGDHL(16), PIPOX(3), PLOD1(7), PLOD2(13), PLOD3(16), RDH11(1), RDH12(3), RDH13(5), SETD1A(18), SETD7(2), SETDB1(18), SHMT1(4), SHMT2(9), SPCS1(3), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5)	24889355	319	103	294	92	98	75	9	53	80	4	0.123	1.000	1.000
263	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(1), B3GALNT1(3), B3GALT1(3), B3GALT2(7), B3GALT4(7), B3GALT5(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALNT1(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT6(4), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GBGT1(2), GCNT2(2), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(11), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGX(2), PIGZ(4), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8), UGCG(3)	20790706	262	103	243	90	87	50	6	47	69	3	0.747	1.000	1.000
264	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ABP1(16), ACAT1(5), ACAT2(4), ACMSD(5), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CAT(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP4F8(2), CYP51A1(8), EHHADH(7), GCDH(8), HAAO(1), HADHA(4), KMO(4), KYNU(11), MAOA(2), MAOB(3), SDS(4), TDO2(7), TPH1(3), WARS(5), WARS2(10)	23202205	306	103	284	86	83	74	6	59	81	3	0.166	1.000	1.000
265	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), G6PC2(1), GALM(4), GAPDH(2), GAPDHS(4), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKL(5), PFKM(3), PFKP(15), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1)	24964559	303	102	289	106	78	90	9	68	57	1	0.425	1.000	1.000
266	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(16), AGXT(1), AGXT2(8), AKR1B10(6), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(7), GNMT(4), HSD3B7(6), MAOA(2), MAOB(3), PEMT(1), PHGDH(3), PIPOX(3), PISD(5), PSAT1(5), PSPH(2), RDH11(1), RDH12(3), RDH13(5), SARDH(13), SARS(8), SARS2(7), SDS(4), SHMT1(4), SHMT2(9), TARS(7), TARS2(7)	18301593	236	102	223	76	71	61	14	39	49	2	0.314	1.000	1.000
267	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), DAG1(13), DGKA(7), ETFA(1), GCA(2), ITGA9(8), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAPK1(3), MAPK3(1), NR1I3(4), PAK1(5), PDE3A(13), PDE3B(20), PI3(2), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PLDN(1), PSME1(3), RIPK3(5), RPS4X(1), SGCB(4), VASP(2)	19922709	246	102	236	74	78	62	9	49	44	4	0.0719	1.000	1.000
268	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(4), BRAF(16), CAMP(2), CREB1(3), CREB3(7), CREB5(5), CREBBP(40), CRKL(1), DAG1(13), EGR1(10), EGR2(8), EGR3(6), EGR4(6), ELK1(3), FRS2(4), GNAQ(4), JUN(4), MAP1B(20), MAP2K4(9), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), NTRK1(10), OPN1LW(6), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PTPN11(6), RPS6KA3(4), SHC1(7), SRC(3), TERF2IP(5), TH(3)	20776834	283	102	269	88	91	69	4	51	66	2	0.102	1.000	1.000
269	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(2), CALM2(2), CD3E(2), CD3G(1), ELK1(3), FOS(1), FYN(10), GRB2(4), JUN(4), LAT(3), LCK(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PIK3R1(11), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), PTPN7(7), RAF1(10), RASA1(17), RELA(5), SHC1(7), SOS1(7), SYT1(4), VAV1(9), ZAP70(14)	19599314	262	102	251	63	86	60	6	40	67	3	0.00421	1.000	1.000
270	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(16), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), COMT(4), DBH(6), DCT(13), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HGD(4), HPD(1), MAOA(2), MAOB(3), PNMT(8), TAT(5), TH(3), TPO(24), TYR(9)	13167243	208	102	190	62	57	45	3	51	48	4	0.253	1.000	1.000
271	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DGAT1(3), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), GK(3), GLA(3), GLB1(5), LCT(22), LIPC(4), LIPF(5), LIPG(4), LPL(7), PNLIP(4), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(3), PPAP2B(1), PPAP2C(4)	20656971	252	101	241	93	71	64	7	52	56	2	0.626	1.000	1.000
272	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(6), ARHGEF11(18), BCL2(3), CDC42(1), DLG4(3), GNA13(5), LPA(16), MAP2K4(9), MAP3K1(11), MAP3K5(5), MAPK8(6), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PDK1(3), PHKA2(10), PI3(2), PIK3CB(13), PLD1(19), PLD2(15), PLD3(6), PTK2(11), RDX(7), ROCK1(18), ROCK2(12), SERPINA4(2), SRF(2), TBXA2R(8)	21046269	261	101	247	71	83	63	11	36	63	5	0.0849	1.000	1.000
273	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(16), AGMAT(2), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH4A1(4), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(3), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), GAMT(1), GATM(3), GLUD1(2), GOT1(3), GOT2(2), MAOA(2), MAOB(3), NOS1(28), NOS3(10), OAT(2), ODC1(3), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(3), PYCR1(1), RARS(5), SMS(5)	18952255	255	100	237	73	74	66	10	47	57	1	0.116	1.000	1.000
274	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(6), APH1A(1), CREBBP(40), CTBP1(3), CTBP2(8), DLL1(15), DLL3(7), DLL4(4), DTX1(14), DTX2(5), DTX3(2), DTX3L(2), DTX4(7), DVL1(7), DVL2(6), DVL3(12), EP300(21), HDAC1(5), HDAC2(2), JAG1(12), JAG2(8), MAML1(5), MAML2(7), MAML3(8), NCOR2(30), NCSTN(7), NOTCH1(27), NOTCH2(25), NOTCH3(22), NOTCH4(16), NUMB(3), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(2), PTCRA(2), RBPJ(8), RBPJL(6), RFNG(2), SNW1(5)	29602732	371	100	361	156	135	82	14	63	76	1	0.855	1.000	1.000
275	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(3), CHUK(4), DAXX(10), EGF(9), EGFR(15), ETS1(8), ETS2(4), FOS(1), HOXA7(4), IKBKB(7), JUN(4), MAP2K1(5), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP3K5(5), MAPK1(3), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), NFKB1(7), NFKBIA(1), PPP2CA(2), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), RAF1(10), RELA(5), RIPK1(2), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4)	20786976	231	100	223	84	76	54	7	45	46	3	0.411	1.000	1.000
276	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(45), B3GALT4(7), CDR1(5), DGKI(15), IL6ST(6), PIGK(3), RPL10(7), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL15(1), RPL18(1), RPL19(2), RPL22(2), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(1), RPL5(3), RPL6(2), RPL7(1), RPL7A(5), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(2), RPS11(2), RPS13(3), RPS14(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS27(1), RPS27A(2), RPS3(2), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(4), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), RPS7(1), RPS9(1), RPSA(2), SLC36A2(7), TBC1D10C(5), TSPAN9(2), UBA52(2), UBC(9)	22452226	246	100	238	77	62	68	11	50	53	2	0.520	1.000	1.000
277	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(16), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), ESCO1(7), ESCO2(8), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MIF(1), MPO(7), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), PRDX6(2), SH3GLB1(3), TAT(5), TPO(24)	14248371	204	99	190	57	60	43	6	48	45	2	0.202	1.000	1.000
278	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(23), ACACB(34), ACAT1(5), ACAT2(4), ACOT12(5), ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), LDHD(5), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PCK2(9), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7), PKM2(6)	20067838	253	99	240	86	76	67	7	50	50	3	0.460	1.000	1.000
279	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(2), ACADM(4), ACOX1(5), ACOX2(6), ACOX3(11), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADIPOQ(3), ANGPTL4(2), APOA1(8), APOA5(4), AQP7(2), CD36(2), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), CYP27A1(5), CYP4A11(2), CYP4A22(2), CYP7A1(6), CYP8B1(7), EHHADH(7), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(3), GK2(7), HMGCS2(3), ILK(8), LPL(7), ME1(2), MMP1(2), NR1H3(6), OLR1(2), PCK1(11), PCK2(9), PDPK1(2), PLTP(2), PPARA(4), PPARD(8), PPARG(4), RXRA(6), RXRB(4), RXRG(5), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(6), SLC27A4(10), SLC27A5(5), SLC27A6(8), SORBS1(9), UBC(9), UCP1(3)	28118351	302	99	291	100	107	53	20	65	54	3	0.369	1.000	1.000
280	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(4), CALM1(2), CALM2(2), ELK1(3), FCER1A(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PAK2(7), PIK3R1(11), PLA2G4A(6), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9)	17251998	221	98	212	53	75	54	7	33	49	3	0.00322	1.000	1.000
281	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(16), AGXT(1), AGXT2(8), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CPT1B(5), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(7), MAOA(2), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(19), PLCG2(15), PSPH(2), SARDH(13), SARS(8), SHMT1(4), SHMT2(9), TARS(7)	18004346	229	98	216	72	65	54	11	44	53	2	0.376	1.000	1.000
282	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(5), EEF1B2(3), EEF1D(5), EEF1G(3), EEF2(9), EEF2K(10), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(5), EIF2AK3(15), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4A1(4), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4EBP2(2), EIF4G1(23), EIF4G3(17), EIF5(6), EIF5A(5), EIF5B(21), ETF1(4), GSPT2(6), KIAA0664(16), PABPC1(2), PABPC3(10), PAIP1(1), SLC35A4(6)	18741103	232	98	215	56	64	62	8	44	51	3	0.0199	1.000	1.000
283	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(8), BAD(3), BAK1(4), BAX(6), BCL2(3), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(2), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP9(3), CHUK(4), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(8), IKBKB(7), IRF1(5), IRF3(3), IRF4(7), IRF5(4), IRF6(5), IRF7(1), JUN(4), LTA(4), MAP2K4(9), MAP3K1(11), MAPK10(5), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), NFKBIB(6), PLEKHG5(8), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFSF10(5), TP73(5), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4)	23443633	254	97	243	77	67	59	10	47	69	2	0.254	1.000	1.000
284	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(16), CARM1(5), CCND1(1), CREBBP(40), EP300(21), ERCC3(8), ESR1(9), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(11), HDAC6(7), MEF2C(4), NCOR2(30), NR0B1(5), NRIP1(17), PELP1(6), POLR2A(19), SRA1(1), TBP(3)	19723106	275	97	262	75	94	70	7	45	57	2	0.0148	1.000	1.000
285	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(18), ATP4A(17), ATP4B(4), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(2), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(6), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(2), COX15(6), COX4I1(6), COX4I2(1), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), COX8C(4), CYC1(3), LHPP(4), NDUFA1(1), NDUFA10(4), NDUFA12(2), NDUFA13(3), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(4), NDUFAB1(2), NDUFB11(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(2), NDUFC2(1), NDUFS1(9), NDUFS2(5), NDUFS3(1), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(5), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), SDHD(1), TCIRG1(7), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1)	23452838	280	97	268	100	92	69	11	57	51	0	0.634	1.000	1.000
286	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1C1(3), AKR1C2(1), AKR1C3(2), AKR1C4(6), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), CYP1A1(5), CYP1A2(5), CYP1B1(2), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2F1(4), CYP2S1(6), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(9), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), MGST1(3), MGST2(3), MGST3(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6)	24504533	253	97	243	68	58	70	4	66	54	1	0.0797	1.000	1.000
287	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAD(3), BAX(6), BCL2(3), BCL2L2(2), BOK(1), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP9(3), CD40(3), CD40LG(5), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKE(12), LTA(4), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(6), NTRK1(10), PTPN13(24), RIPK1(2), SFRS2IP(13), TFG(1), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4), TRAF6(6)	18099189	201	96	190	68	44	46	13	47	49	2	0.542	1.000	1.000
288	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CDK5(2), F2(9), FYN(10), GNA11(6), GNAI1(1), GNB1(1), GNGT1(3), GRB2(4), JAK2(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPT(7), MYLK(32), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), SYT1(4)	17859302	223	95	210	75	73	58	8	42	39	3	0.374	1.000	1.000
289	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(7), F11(3), F12(3), F13B(16), F2(9), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), LPA(16), PLAT(7), PLAU(7), PLG(14), SERPINB2(8), SERPINE1(3), SERPINF2(8), VWF(28)	15158900	207	95	199	54	56	45	9	57	39	1	0.0644	1.000	1.000
290	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(8), CDC7(4), CDK2(3), CDT1(7), DIAPH2(7), GMNN(1), MCM10(10), MCM2(14), MCM3(6), MCM4(12), MCM5(8), MCM6(8), MCM7(7), NACA(2), ORC1L(8), ORC2L(3), ORC3L(3), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), PRIM1(2), RFC1(9), RFC2(1), RFC3(3), RFC4(1), RFC5(1), RPA1(2), RPA2(2), RPA3(2), RPA4(6), RPS27A(2), UBA52(2), UBC(9)	21753848	220	95	214	63	76	43	12	39	48	2	0.142	1.000	1.000
291	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(2), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CLC(1), CPT1B(5), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), ETNK1(2), GNPAT(1), GPD1(7), GPD2(6), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(12), PAFAH2(3), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB2(8), PLCG1(19), PLCG2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4)	21257977	242	95	232	89	78	62	8	46	46	2	0.610	1.000	1.000
292	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(19), CALM1(2), CALM2(2), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(4), GNAS(27), GNB1(1), GNGT1(3), JUN(4), MAP2K1(5), MAPK3(1), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RAF1(10), RPS6KA3(4), SYT1(4)	15033057	220	95	209	69	89	52	4	35	40	0	0.0875	1.000	1.000
293	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(3), CRKL(1), DOCK1(17), ELK1(3), FOS(1), GAB1(3), GRB2(4), HGF(15), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(1), MAPK8(6), MET(8), PAK1(5), PIK3R1(11), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAF1(10), RAP1A(2), RAP1B(6), RASA1(17), SOS1(7), SRC(3), STAT3(7)	17658832	204	95	192	64	56	45	9	48	43	3	0.256	1.000	1.000
294	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), HRH1(5), HRH2(8), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10)	11062835	229	95	222	81	89	50	13	50	27	0	0.116	1.000	1.000
295	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(38), BMPR1B(7), CCND2(3), DMC1(8), EGR1(10), ESR2(9), GJA4(4), INHA(5), LHCGR(11), MLH1(6), MSH5(4), NCOR1(26), NR5A1(5), NRIP1(17), PGR(15), PRLR(4), PTGER2(5), SMPD1(8), VDR(2), ZP2(9)	14401287	196	95	183	56	46	55	9	34	48	4	0.160	1.000	1.000
296	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(10), AKT1(3), AKT2(8), AKT3(6), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PDK1(3), PHKA2(10), PIK3CB(13), PITX2(6), PLD1(19), PLD2(15), PLD3(6), VN1R1(3)	19243480	261	95	253	70	93	59	14	48	44	3	0.0210	1.000	1.000
297	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(2), ALDH4A1(4), ALDH5A1(6), CAD(18), CPS1(22), EARS2(3), EPRS(12), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GFPT2(5), GLS(8), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), GMPS(7), GNPNAT1(4), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSR(5), GSS(3), NADSYN1(8), NAGK(1), PPAT(5), QARS(5)	16949877	185	94	183	71	52	53	7	45	28	0	0.740	1.000	1.000
298	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	68	CALR(5), CANX(3), CD74(1), CD8A(4), CD8B(1), CIITA(16), CREB1(3), CTSB(3), CTSL1(2), CTSS(2), HLA-C(13), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-G(5), HSP90AA1(11), HSP90AB1(6), HSPA5(2), IFI30(2), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL1(4), KIR2DL3(2), KIR2DL4(3), KIR2DS4(2), KIR3DL1(7), KLRC1(3), KLRC2(1), KLRC3(1), KLRD1(4), LGMN(6), LTA(4), NFYA(1), NFYC(2), PDIA3(3), PSME1(3), PSME2(1), RFX5(11), RFXANK(4), RFXAP(1), TAP1(4), TAP2(13), TAPBP(7)	18471811	221	94	211	60	37	61	18	50	53	2	0.111	1.000	1.000
299	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MIOX(5), OCRL(9), PIK3C2A(14), PIK3C2B(20), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PLCB1(18), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15)	18252148	244	94	226	73	74	56	10	50	53	1	0.340	1.000	1.000
300	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(2), ALOX12(5), ALOX15(7), ALOX5(10), CBR1(1), CBR3(2), CYP4F2(6), CYP4F3(11), EPX(9), GGT1(6), LPO(9), LTA4H(5), MPO(7), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4), TPO(24)	11835282	172	94	168	51	61	29	10	43	27	2	0.128	1.000	1.000
301	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(5), ARHGAP5(18), ARHGAP6(9), ARHGEF1(11), ARHGEF11(18), ARHGEF5(5), ARPC1A(3), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(11), GSN(11), LIMK1(4), MYL2(8), MYLK(32), OPHN1(9), PIP5K1A(4), PIP5K1B(1), PPP1R12B(15), ROCK1(18), SRC(3), TLN1(22), VCL(6)	19475904	232	94	211	74	66	57	11	37	57	4	0.475	1.000	1.000
302	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(3), PFKP(15), PGK1(4), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1)	20976024	260	93	247	93	65	73	7	61	53	1	0.614	1.000	1.000
303	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(5), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(3), PFKP(15), PGK1(4), PGM1(3), PGM3(11), PKLR(7), PKM2(6), TPI1(1)	20976024	260	93	247	93	65	73	7	61	53	1	0.614	1.000	1.000
304	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(6), APC(43), AXIN1(9), BTRC(9), CTNNB1(22), DLL1(15), DVL1(7), FZD1(10), GSK3B(5), NOTCH1(27), PSEN1(3), WNT1(8)	9169493	164	93	150	52	47	28	6	28	46	9	0.422	1.000	1.000
305	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(4), CALM1(2), CALM2(2), CD79A(6), CD79B(2), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK14(1), MAPK3(1), MAPK8(6), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9)	16430692	200	92	192	56	78	48	5	32	36	1	0.0291	1.000	1.000
306	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), ATF2(3), CDC42(1), DLD(4), DUSP10(8), DUSP4(1), DUSP8(1), GAB1(3), GCK(4), IL1R1(4), JUN(4), MAP2K4(9), MAP2K5(1), MAP3K1(11), MAP3K10(8), MAP3K11(10), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK10(5), MAPK7(6), MAPK8(6), MAPK9(3), MYEF2(9), NFATC3(4), NR2C2(3), PAPPA(25), SHC1(7), TRAF6(6), ZAK(8)	20962605	232	92	227	76	62	62	15	40	51	2	0.368	1.000	1.000
307	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(38), ATR(18), BRCA1(16), CCNB1(3), CDC25A(6), CDC25B(4), CDC34(2), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), EP300(21), MDM2(5), MYT1(19), PRKDC(40), RPS6KA1(9), WEE1(4), YWHAH(3), YWHAQ(2)	17173734	208	91	199	66	55	58	7	43	41	4	0.500	1.000	1.000
308	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(2), CASP2(3), CASP3(2), CRADD(1), DFFA(4), DFFB(3), FADD(1), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MADD(17), MAP2K4(9), MAP3K1(11), MAP3K7(10), MAPK8(6), PAK1(5), PAK2(7), PRKDC(40), RB1(13), RIPK1(2), SPTAN1(20), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	16108101	192	91	189	63	54	52	10	29	44	3	0.397	1.000	1.000
309	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(18), DIAPH1(11), FYN(10), GSN(11), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), MYLK(32), PIK3R1(11), PTK2(11), PXN(4), RAF1(10), ROCK1(18), SHC1(7), SRC(3), TLN1(22)	15078096	203	90	181	48	52	46	9	40	51	5	0.0367	1.000	1.000
310	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CFLAR(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAF1(8), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MAP2K4(9), MAP3K1(11), MAP3K7(10), MAPK8(6), PAK1(5), PAK2(7), PRKDC(40), PTPN13(24), RB1(13), RIPK2(1), SPTAN1(20)	16909222	206	90	201	62	47	62	10	34	51	2	0.220	1.000	1.000
311	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(6), CALCRL(8), CD97(4), CRHR1(11), CRHR2(4), ELTD1(17), EMR1(13), EMR2(9), GHRHR(4), GIPR(3), GLP1R(1), GLP2R(8), GPR64(12), LPHN1(19), LPHN2(19), LPHN3(17), SCTR(3), VIPR1(3), VIPR2(3)	11421754	171	90	166	52	44	43	7	54	21	2	0.104	1.000	1.000
312	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(6), AKR1D1(3), ARSD(4), ARSE(5), CARM1(5), CYP11B1(12), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD11B2(3), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(1), HSD17B7(3), HSD3B1(4), HSD3B2(3), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SRD5A1(3), SRD5A2(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), WBSCR22(6)	21453585	223	90	216	70	54	70	9	40	49	1	0.169	1.000	1.000
313	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(6), EGF(9), EGFR(15), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3)	15164766	184	89	175	51	51	47	6	30	48	2	0.104	1.000	1.000
314	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), ELK1(3), FPR1(6), GNA15(3), GNB1(1), GNGT1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NCF1(3), NCF2(4), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(10), PLCB1(18), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), RELA(5), SYT1(4)	16399444	195	89	185	67	68	44	4	36	43	0	0.385	1.000	1.000
315	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACADVL(1), ACAT1(5), ACAT2(4), ACOX1(5), ACOX3(11), ACSL1(3), ACSL3(7), ACSL4(4), ACSL5(9), ACSL6(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CPT1A(9), CPT1B(5), CPT1C(7), CPT2(5), CYP4A11(2), CYP4A22(2), DCI(4), EHHADH(7), GCDH(8), HADH(3), HADHA(4), HADHB(5), HSD17B4(6), PECI(3)	21011347	231	89	216	64	52	64	7	50	56	2	0.0868	1.000	1.000
316	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(3), ACAA2(5), ACADM(4), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), AUH(7), BCAT1(5), BCAT2(6), BCKDHA(15), BCKDHB(3), DBT(5), DLD(4), EHHADH(7), HADH(3), HADHA(4), HADHB(5), HIBADH(3), HMGCS1(2), HMGCS2(3), HSD17B4(6), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), OXCT2(3), PCCA(8), PCCB(5)	18452974	213	89	197	70	46	59	4	40	61	3	0.632	1.000	1.000
317	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(3), ARG2(2), ASL(6), ASS1(9), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), EPRS(12), GAMT(1), GATM(3), GLUD1(2), GLUD2(11), GOT1(3), GOT2(2), LAP3(2), NOS1(28), NOS3(10), OAT(2), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), PYCR1(1), PYCR2(1), PYCRL(2), RARS(5), RARS2(6)	15394352	182	89	178	52	59	46	10	41	26	0	0.0818	1.000	1.000
318	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(5), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ACSM1(5), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), BDH1(5), DDHD1(12), EHHADH(7), GAD1(7), GAD2(9), HADH(3), HADHA(4), HMGCS1(2), HMGCS2(3), HSD17B4(6), HSD3B7(6), ILVBL(5), L2HGDH(2), OXCT1(8), OXCT2(3), PDHA1(1), PDHA2(6), PDHB(4), PLA1A(2), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(5)	17394750	199	89	186	76	62	45	4	42	45	1	0.800	1.000	1.000
319	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F1(5), GTF2F2(2), GTF2H1(2), GTF2H3(2), GTF2H4(7), GTF2I(4), GTF2IRD1(13), TAF1(20), TAF10(1), TAF13(1), TAF1L(29), TAF2(13), TAF4(12), TAF4B(3), TAF5(2), TAF5L(6), TAF6(12), TAF6L(5), TAF7(7), TAF7L(7), TAF9B(4), TBPL1(2), TBPL2(7)	15449868	181	89	174	43	49	39	10	34	49	0	0.0486	1.000	1.000
320	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), PDGFA(2), PDGFRA(15), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3)	14061063	177	89	169	44	48	49	5	28	45	2	0.0270	1.000	1.000
321	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(8), AZIN1(2), CBX3(1), CLDN5(3), CLOCK(5), CRY1(3), CRY2(5), DAZAP2(6), DNAJA1(6), EIF4G2(7), ETV6(7), G0S2(2), GFRA1(9), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(4), IDI1(2), KLF9(2), MYF6(5), NCKAP1(9), NCOA4(5), NR1D2(6), PER1(4), PER2(15), PIGF(1), PPP1R3C(4), PPP2CB(3), PSMA4(4), PURA(1), SF3A3(3), SUMO3(3), TOB1(1), TUBB3(13), UCP3(3), UGP2(7), VAPA(3), ZFR(13)	15664745	180	88	176	55	51	43	9	38	38	1	0.321	1.000	1.000
322	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(16), ACY3(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CARM1(5), CNDP1(6), FTCD(5), HAL(4), HARS(9), HARS2(4), HDC(8), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), PRPS1(3), PRPS2(3), UROC1(10), WBSCR22(6)	16550436	216	88	196	58	55	53	8	38	58	4	0.109	1.000	1.000
323	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(6), C1GALT1(3), C1GALT1C1(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL1(11), GALNTL2(10), GALNTL4(12), GALNTL5(3), GCNT3(3), GCNT4(4), OGT(5), ST3GAL1(4), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(25)	13869210	188	88	179	68	64	40	8	37	38	1	0.828	1.000	1.000
324	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(12), ADRBK2(5), ARRB2(1), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CLCA1(10), CLCA2(6), CLCA4(12), CNGA3(8), CNGA4(19), CNGB1(15), GNAL(3), GUCA1A(3), GUCA1B(2), GUCA1C(4), PDC(2), PDE1C(11), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(9), PRKG2(13), PRKX(5)	13099384	178	88	170	58	58	38	5	41	35	1	0.284	1.000	1.000
325	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(43), ASAH1(4), CAMP(2), CASP3(2), CERK(6), CREB1(3), CREB3(7), CREB5(5), CXCL2(2), DAG1(13), EPHB2(12), FOS(1), GNAQ(4), ITPKA(2), ITPKB(11), JUN(4), MAP2K4(9), MAPK1(3), MAPK10(5), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3)	11948394	168	88	164	42	45	42	3	30	39	9	0.0296	1.000	1.000
326	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(6), AARS2(11), ABAT(3), ACY3(1), ADSL(5), ADSS(5), ADSSL1(8), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), ASRGL1(2), ASS1(9), CAD(18), CRAT(5), DARS(2), DARS2(3), DDO(6), DLAT(3), DLD(4), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15), PDHA1(1), PDHA2(6), PDHB(4)	16218924	171	87	168	67	62	46	1	36	26	0	0.759	1.000	1.000
327	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(6), AARS2(11), CARS(4), CARS2(5), DARS(2), DARS2(3), EARS2(3), EPRS(12), FARS2(7), FARSA(3), FARSB(1), GARS(4), HARS(9), HARS2(4), IARS(10), IARS2(9), KARS(5), LARS(5), LARS2(7), MARS(4), MARS2(2), MTFMT(1), NARS(5), QARS(5), RARS(5), RARS2(6), SARS(8), SARS2(7), TARS(7), TARS2(7), VARS(16), VARS2(12), WARS(5), WARS2(10), YARS(6), YARS2(2)	23293919	218	87	214	70	71	63	9	43	32	0	0.363	1.000	1.000
328	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(6), ARSB(2), FUCA1(1), FUCA2(2), GALNS(1), GBA(9), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(22), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NAGLU(6), NEU1(3), NEU2(6), NEU3(5), NEU4(2), SPAM1(9)	14764926	190	87	186	60	59	52	9	32	36	2	0.233	1.000	1.000
329	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(9), ADCY3(12), ADCY9(13), AK1(1), ARF1(5), ARF4(1), ARF5(1), ARL4D(1), ATP6V0A1(9), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(1), GNAS(27), PDIA4(3), PLCG1(19), PLCG2(15), PRKCA(5), SEC61A1(5), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(5)	15886250	203	87	190	70	78	37	6	42	40	0	0.556	1.000	1.000
330	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(4), ELK1(3), FOS(1), IKBKB(7), IRAK1(6), JUN(4), LY96(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP3K7(10), MAPK14(1), MAPK8(6), MYD88(4), NFKB1(7), NFKBIA(1), PPARA(4), RELA(5), TIRAP(1), TLR10(7), TLR2(2), TLR3(6), TLR4(21), TLR6(3), TLR7(5), TLR9(16), TOLLIP(5), TRAF6(6)	15655244	171	87	164	57	48	37	7	38	39	2	0.397	1.000	1.000
331	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(6), EIF1(1), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), ELAVL1(9), FLT1(16), FLT4(24), HIF1A(7), KDR(13), NOS3(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PXN(4), SHC1(7), VHL(2)	13639951	181	87	174	45	57	44	8	31	40	1	0.0234	1.000	1.000
332	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(3), CDK5(2), CDK5R1(4), CFL1(1), CHN1(3), LIMK1(4), MAP3K1(11), MYL2(8), MYLK(32), NCF2(4), PAK1(5), PDGFRA(15), PIK3R1(11), PLD1(19), PPP1R12B(15), RALBP1(8), RPS6KB1(5), TRIO(39), VAV1(9), WASF1(5)	14051946	203	86	190	64	57	54	2	37	50	3	0.519	1.000	1.000
333	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(18), CPS1(22), EPRS(12), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GLS(8), GLS2(7), GLUD1(2), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSS(3), NADSYN1(8), PPAT(5), QARS(5)	14245065	154	85	154	55	45	46	5	35	23	0	0.593	1.000	1.000
334	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(6), ALDOC(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GAPDHS(4), GCK(4), GOT1(3), GOT2(2), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MDH1(3), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PFKL(5), PFKM(3), PFKP(15), PGAM2(5), PGK1(4), PGK2(3), PKLR(7), PKM2(6), TNFAIP1(4), TPI1(1)	18230069	201	85	195	86	67	59	4	39	31	1	0.864	1.000	1.000
335	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(5), ALOX12B(10), ALOX15(7), ALOX15B(3), ALOX5(10), CBR1(1), CBR3(2), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP2U1(6), CYP4A11(2), CYP4A22(2), CYP4F2(6), CYP4F3(11), DHRS4(1), EPHX2(4), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GPX6(4), GPX7(3), LTA4H(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4)	16563665	192	85	188	52	67	46	6	45	27	1	0.0202	1.000	1.000
336	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(23), ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHB(4), LDHC(1), LDHD(5), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7), PKM2(6)	15844517	192	84	182	70	57	56	4	35	38	2	0.670	1.000	1.000
337	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(11), BLNK(4), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8IP3(13), PAPPA(25), RPS6KA1(9), RPS6KA3(4), SHC1(7), SOS1(7), SYK(7), VAV1(9), VAV2(12), VAV3(10)	13738984	158	84	153	62	51	44	3	32	27	1	0.640	1.000	1.000
338	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(7), ACTN2(23), ACTN3(4), CAPN1(5), CAPNS1(2), CAPNS2(2), ITGA1(8), ITGB1(10), ITGB3(7), PTK2(11), PXN(4), SPTAN1(20), SRC(3), TLN1(22)	12238790	131	84	126	62	57	28	8	25	13	0	0.918	1.000	1.000
339	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(16), ACADL(2), ACADM(4), ACADSB(7), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SDS(4), SMS(5), UPB1(4)	12474673	183	83	166	50	42	50	3	37	50	1	0.125	1.000	1.000
340	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(27), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14)	9488059	176	82	168	66	67	47	2	27	33	0	0.592	1.000	1.000
341	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(2), ATF2(3), CALM1(2), CALM2(2), EGFR(15), ELK1(3), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PAK1(5), PRKCA(5), PTK2(11), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4)	14383282	166	82	159	53	56	35	9	26	39	1	0.270	1.000	1.000
342	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(27), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14)	9488059	176	82	168	66	67	47	2	27	33	0	0.592	1.000	1.000
343	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(16), ACADM(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SMS(5), SRM(1), UPB1(4)	11585589	160	82	143	42	37	41	3	32	46	1	0.106	1.000	1.000
344	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(3), ALAS2(12), BLVRA(4), BLVRB(1), COX10(2), COX15(6), CP(10), CPOX(2), EARS2(3), EPRS(12), FECH(6), FTH1(4), FTMT(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), MMAB(3), PPOX(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UROD(1), UROS(4)	18014594	180	82	179	61	37	51	8	46	38	0	0.606	1.000	1.000
345	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADHA(4), PLOD1(7), PLOD2(13), PLOD3(16), SDS(4), SHMT1(4), SHMT2(9), TMLHE(5)	15854463	207	82	186	63	55	54	3	30	63	2	0.266	1.000	1.000
346	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(5), CAPN2(8), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(15), ITGA1(8), ITGB1(10), MAPK1(3), MAPK3(1), MYL2(8), MYLK(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTK2(11), PXN(4), TLN1(22)	14031620	175	82	158	66	60	39	9	29	36	2	0.637	1.000	1.000
347	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(2), DLG4(3), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(6), NOS1(28), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), SYT1(4)	10962140	155	82	151	60	55	35	5	31	29	0	0.554	1.000	1.000
348	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(6), CFL1(1), GNAQ(4), GNAS(27), GNB1(1), GNGT1(3), LIMK1(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), NOX1(6), PIK3C2G(10), PLCB1(18), PPP1R12B(15), PRKCA(5), PTK2(11), RAF1(10), ROCK2(12)	10800778	151	81	143	42	56	27	4	32	31	1	0.291	1.000	1.000
349	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(15), ELK1(3), GNAS(27), GNB1(1), GNGT1(3), GRB2(4), IGF1R(16), ITGB1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MYC(5), NGFR(4), PDGFRA(15), PPP2CA(2), PTPRR(12), RAF1(10), RPS6KA1(9), RPS6KA5(3), SHC1(7), SOS1(7), SRC(3), STAT3(7)	14218333	186	81	175	81	68	46	0	45	26	1	0.915	1.000	1.000
350	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), AVP(3), CABIN1(15), CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), HDAC5(11), IGF1(4), IGF1R(16), INSR(14), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(7), NFATC1(13), NFATC2(17), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYT1(4), YWHAH(3)	13979056	180	81	174	65	66	43	6	29	35	1	0.304	1.000	1.000
351	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(5), ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH5(3), ADH6(8), ADH7(1), ADHFE1(9), AKR1B10(6), AKR1C4(6), AKR1D1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), HSD3B7(6), LIPA(3), RDH11(1), RDH12(3), RDH13(5), SLC27A5(5), SOAT1(7), SOAT2(2), SRD5A1(3), SRD5A2(3)	13577969	182	81	170	49	40	57	9	39	36	1	0.0465	1.000	1.000
352	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(23), ACACB(34), ACADM(4), ACAT1(5), ACAT2(4), ACSS1(12), ACSS2(10), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SUCLA2(4), SUCLG1(2), SUCLG2(5)	17041403	209	81	192	58	50	55	5	44	51	4	0.185	1.000	1.000
353	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(4), ATP6AP1(6), ATP6V0A1(9), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(12), ATP7B(13), COX10(2), COX4I1(6), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(9), NDUFS2(5), NDUFV1(5), PPA2(3), SDHA(6), SDHB(4), SHMT1(4), UQCRB(1), UQCRC1(2), UQCRFS1(1)	15912824	195	81	184	64	60	46	8	38	42	1	0.494	1.000	1.000
354	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), GRB2(4), GSK3A(3), GSK3B(5), IL4R(3), IRS1(24), IRS2(6), JAK1(12), JAK3(13), MAP4K1(4), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PIK3R1(11), PPP1R13B(11), RAF1(10), SHC1(7), SOCS1(1), SOS1(7), SOS2(19), STAT6(3)	14742335	184	81	173	48	61	39	3	28	50	3	0.121	1.000	1.000
355	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(4), MAP2K4(9), MAP3K1(11), MAP3K14(5), MAPK10(5), MCL1(1), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), PARP1(10), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(5), TRADD(2), TRAF1(3), TRAF2(4)	15184336	158	80	149	45	43	36	3	31	43	2	0.185	1.000	1.000
356	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), FPGT(4), FUK(5), GMDS(2), GMPPA(6), GMPPB(6), HK1(16), HK2(10), HK3(6), HSD3B7(6), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(5), MTMR6(7), PFKFB1(6), PFKFB2(6), PFKFB3(7), PFKFB4(4), PFKL(5), PFKM(3), PFKP(15), PGM2(1), PHPT1(2), PMM1(2), PMM2(2), RDH11(1), RDH12(3), RDH13(5), SORD(2), TPI1(1), TSTA3(8)	15931702	196	80	190	59	73	56	5	28	34	0	0.0412	1.000	1.000
357	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(6), POLA2(4), POLB(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLG(8), POLG2(5), POLH(6), POLI(2), POLK(8), POLL(3), POLQ(33), PRIM1(2), PRIM2(4), REV1(8), REV3L(38), RFC5(1)	17037861	189	80	182	58	49	41	5	33	59	2	0.613	1.000	1.000
358	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(3), BRAF(16), CREB1(3), CREB3(7), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(5), EEF2K(10), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MOS(11), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), SHC1(7), SOS1(7), SOS2(19), TRAF3(4)	12642981	160	80	150	60	41	37	3	36	41	2	0.812	1.000	1.000
359	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(1), AKT1(3), AKT2(8), AKT3(6), BAD(3), BTK(4), DAPP1(1), GRB2(4), GSK3A(3), GSK3B(5), IARS(10), IGFBP1(9), INPP5D(4), PDK1(3), PPP1R13B(11), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SOS1(7), SOS2(19), TEC(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	13913638	153	80	149	50	40	38	3	32	38	2	0.600	1.000	1.000
360	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), DAG1(13), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFAT5(10), PDE6A(4), PDE6B(10), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(7), TF(15)	15339132	185	80	181	70	68	46	11	32	25	3	0.441	1.000	1.000
361	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(2), CHUK(4), EGR2(8), EGR3(6), GNAQ(4), MAP3K1(11), MYC(5), NFATC1(13), NFATC2(17), NFKB1(7), NFKBIA(1), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), SYT1(4), VIP(5), VIPR2(3)	12007552	168	80	159	48	61	35	3	32	37	0	0.0648	1.000	1.000
362	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(6), B4GALT1(2), B4GALT2(7), G6PC2(1), GAA(5), GALE(3), GALK1(4), GALK2(2), GALT(1), GANC(9), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), LALBA(1), LCT(22), MGAM(15), PFKL(5), PFKM(3), PFKP(15), PGM1(3), PGM3(11), RDH11(1), RDH12(3), RDH13(5), UGP2(7)	16536364	187	79	177	78	68	49	5	26	38	1	0.867	1.000	1.000
363	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	40	ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG5(3), ALG6(2), ALG8(4), ALG9(2), B4GALT1(2), B4GALT2(7), B4GALT3(2), DHDDS(4), DOLPP1(3), DPAGT1(4), DPM1(1), FUT8(7), GANAB(11), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), MGAT5B(5), RFT1(4), RPN1(3), RPN2(6), STT3B(5)	17751119	174	79	165	71	42	40	6	28	54	4	0.973	1.000	1.000
364	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(19), ARHGEF1(11), F2(9), F2R(3), F2RL3(3), GNA12(1), GNA13(5), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP3K7(10), PIK3R1(11), PLCB1(18), PPP1R12B(15), PRKCA(5), PTK2B(16), ROCK1(18)	10149452	153	79	150	51	47	39	2	29	33	3	0.466	1.000	1.000
365	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(8), CALM1(2), CALM2(2), CRKL(1), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(9), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(6), PAK1(5), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4)	12217945	144	79	138	38	50	32	4	24	33	1	0.0845	1.000	1.000
366	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(10), DYRK1B(12), GLI2(14), GLI3(47), GSK3B(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), SHH(4), SMO(13), SUFU(5)	7134953	141	79	134	52	51	25	5	31	27	2	0.426	1.000	1.000
367	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(3), EPHB2(12), F2(9), F2RL1(2), F2RL2(3), F2RL3(3), JUN(4), MAP2K5(1), MAPK1(3), MAPK7(6), MAPK8(6), MYEF2(9), PLD1(19), PLD2(15), PLD3(6), PTK2(11), RAF1(10), RASAL1(7), SRC(3), TEC(4), VAV1(9)	11762632	149	79	148	44	52	35	6	26	29	1	0.151	1.000	1.000
368	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(8), AKT3(6), CISH(3), GRB2(4), IARS(10), IL13RA1(4), IL2RG(6), IL4(1), IL4R(3), INPP5D(4), JAK1(12), JAK2(13), JAK3(13), NR0B2(3), PI3(2), PPP1R13B(11), RPS6KB1(5), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT6(3), TYK2(8)	14883760	160	79	152	49	38	40	2	33	45	2	0.627	1.000	1.000
369	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(38), ATR(18), BRCA1(16), BRCA2(40), CHEK1(4), CHEK2(8), FANCA(7), FANCC(5), FANCD2(13), FANCE(7), FANCG(4), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(9), RAD51(1), RAD9A(4), TREX1(3)	18565736	193	78	181	44	33	46	7	44	58	5	0.262	1.000	1.000
370	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(16), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), TAT(5), TPO(24)	8992015	137	78	125	42	38	26	5	33	33	2	0.476	1.000	1.000
371	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP4F8(2), CYP51A1(8), PON1(2)	12601131	154	77	150	52	64	31	4	26	29	0	0.310	1.000	1.000
372	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(19), EXT2(6), EXTL1(8), EXTL2(2), EXTL3(10), GLCE(5), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), NDST1(11), NDST2(9), NDST3(13), NDST4(12)	8890710	142	77	137	47	43	35	4	38	19	3	0.454	1.000	1.000
373	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(3), ARSD(4), ARSE(5), ASAH1(4), B4GALT6(4), CERK(6), DEGS1(2), DEGS2(1), ENPP7(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(22), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(3), SGMS2(3), SGPP1(2), SGPP2(1), SMPD1(8), SMPD2(3), SMPD3(10), SMPD4(5), SPHK1(6), SPHK2(3), SPTLC1(2), SPTLC2(3), UGCG(3), UGT8(5)	15329572	166	77	165	63	57	43	8	23	34	1	0.593	1.000	1.000
374	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(8), BAIAP2(5), CASP1(4), CASP3(2), CASP7(3), GAPDH(2), INSR(14), ITCH(5), MAGI1(18), MAGI2(30), RERE(28), WWP1(12), WWP2(13)	9790586	144	77	134	41	37	34	6	23	44	0	0.254	1.000	1.000
375	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(18), ARHGEF1(11), GNA12(1), GNA13(5), GNAQ(4), GNB1(1), GNGT1(3), MYL2(8), MYLK(32), PLCB1(18), PPP1R12B(15), PRKCA(5), ROCK1(18)	8871982	139	77	122	40	33	30	2	27	43	4	0.555	1.000	1.000
376	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(40), DUSP1(2), EP300(21), IKBKB(7), IL1B(3), IL8(2), MAP2K3(4), MAP2K6(1), MAP3K14(5), MAP3K7(10), MAPK11(1), MAPK14(1), MYD88(4), NFKB1(7), NFKBIA(1), NR3C1(6), RELA(5), TGFBR1(4), TGFBR2(14), TLR2(2), TNF(3)	12711671	147	77	145	42	41	37	7	29	31	2	0.155	1.000	1.000
377	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(8), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F2(2), GTF2H1(2), GTF2H4(7), ILK(8), MNAT1(3), POLR1A(15), POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3B(13), POLR3D(6), POLR3E(6), POLR3K(1), TAF13(1), TAF5(2), TAF6(12), TAF7(7), TBP(3)	15030146	160	77	157	46	57	41	3	23	35	1	0.147	1.000	1.000
378	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(23), ACTN3(4), BCAR1(8), CSK(7), CTNNA1(15), CTNNA2(19), CTNNB1(22), PTK2(11), PXN(4), SRC(3), VCL(6)	8205698	129	76	124	52	39	27	8	28	24	3	0.823	1.000	1.000
379	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(7), ATM(38), ATR(18), CCNA1(6), CCND1(1), CCNE1(5), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), GSK3B(5), HDAC1(5), RB1(13), SKP2(5), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8)	12359948	144	76	138	47	32	39	4	30	36	3	0.608	1.000	1.000
380	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(2), GHR(6), GRB2(4), INSR(14), IRS1(24), JAK2(13), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), PLCG1(19), PRKCA(5), PTPN6(4), RAF1(10), RPS6KA1(9), SHC1(7), SLC2A4(4), SOCS1(1), SOS1(7), SRF(2), STAT5A(3), STAT5B(14)	13260386	168	76	159	45	47	49	4	24	41	3	0.0740	1.000	1.000
381	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(16), ACY1(3), ADC(2), AGMAT(2), ALDH18A1(7), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(3), ARG2(2), ASL(6), ASS1(9), CPS1(22), GATM(3), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(5), SRM(1)	12641840	164	76	149	39	40	44	5	33	41	1	0.0616	1.000	1.000
382	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CDC42(1), CREB1(3), DAXX(10), DDIT3(4), ELK1(3), GRB2(4), HMGN1(2), HSPB2(1), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MYC(5), PLA2G4A(6), RIPK1(2), RPS6KA5(3), SHC1(7), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4)	15731666	159	76	155	50	44	41	7	22	43	2	0.329	1.000	1.000
383	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(15), BCKDHB(3), EHHADH(7), HADHA(4), HADHB(5), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), PCCA(8), PCCB(5), SDS(4)	15440430	195	76	179	66	37	62	3	35	55	3	0.704	1.000	1.000
384	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(39), MAP2(34), PPP1CA(2), PPP2CA(2), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8), PRKCE(14)	7793931	117	75	111	41	18	32	2	36	25	4	0.831	1.000	1.000
385	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(2), B4GALT2(7), FBP2(5), GAA(5), GALE(3), GALK1(4), GALK2(2), GALT(1), GANAB(11), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), LALBA(1), LCT(22), MGAM(15), PFKM(3), PFKP(15), PGM1(3), PGM3(11)	13947676	160	75	151	66	59	41	4	21	35	0	0.827	1.000	1.000
386	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(19), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CREB1(3), GNAS(27), GRB2(4), MAPK1(3), MAPK14(1), MAPK3(1), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RPS6KA1(9), RPS6KA5(3), SOS1(7)	11573022	144	74	138	53	52	39	1	20	30	2	0.698	1.000	1.000
387	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), ABP1(16), AOC2(6), AOC3(15), CES1(7), CES7(8), DDHD1(12), ESCO1(7), ESCO2(8), LIPA(3), MYST3(28), MYST4(20), NAT6(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(2), SH3GLB1(3)	10873015	148	74	136	39	39	37	5	30	36	1	0.201	1.000	1.000
388	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(12), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(3), ANAPC7(6), BTRC(9), CDC16(7), CDC20(5), CDC23(6), CDC26(1), CDC27(3), CUL1(22), CUL2(6), CUL3(6), FBXW11(10), FZR1(7), ITCH(5), RBX1(1), SKP2(5), SMURF1(5), SMURF2(5), TCEB1(1), UBA1(4), UBE2D3(2), UBE2E3(3), VHL(2), WWP1(12), WWP2(13)	16490181	171	74	162	42	54	48	2	29	38	0	0.0369	1.000	1.000
389	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2F1(5), HDAC3(6), NCOA1(17), NCOA2(22), NCOA3(16), NCOR2(30), POLR2A(19), RARA(3), RXRA(6), TBP(3)	10675277	148	74	144	48	44	47	4	25	28	0	0.285	1.000	1.000
390	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CDC42(1), CREB1(3), CREB3(7), CREB5(5), DUSP1(2), DUSP10(8), EEF2K(10), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K10(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK1(3), MKNK2(7), MYEF2(9), NFKB1(7), NR2C2(3), SRF(2), TRAF6(6)	14301914	156	74	154	47	37	47	10	27	35	0	0.137	1.000	1.000
391	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(7), ATM(38), BRCA1(16), CDKN1A(3), CHEK1(4), CHEK2(8), JUN(4), MAPK8(6), MDM2(5), MRE11A(5), NFKB1(7), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(5), TP73(5)	12429810	131	73	123	36	24	29	6	29	39	4	0.480	1.000	1.000
392	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(8), ACO2(9), CLYBL(3), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), OGDHL(16), PC(15), PCK1(11), PCK2(9), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5)	12830038	144	73	137	46	53	32	6	19	29	5	0.296	1.000	1.000
393	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(40), DAXX(10), PAX3(11), PML(12), RARA(3), RB1(13), SIRT1(6), SP100(15), TNF(3), TNFRSF1A(6), TNFRSF1B(3)	7805750	122	73	119	31	42	34	2	17	27	0	0.0344	1.000	1.000
394	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), P4HB(3), SLC23A1(5), SLC23A2(11), SLC2A1(6), SLC2A3(8)	10760945	126	73	123	50	38	37	3	25	22	1	0.533	1.000	1.000
395	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), L2HGDH(2), OXCT1(8), PDHA1(1), PDHA2(6), PDHB(4), SDHB(4), SDS(4)	11064699	143	72	134	55	41	36	0	30	35	1	0.802	1.000	1.000
396	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(19), AKT1(3), ASAH1(4), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(13), ITGB3(7), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(15), PIK3R1(11), PLCB1(18), PRKCA(5), PTK2(11), SMPD1(8), SMPD2(3), SPHK1(6), SRC(3)	10836767	137	72	132	55	41	42	4	18	31	1	0.715	1.000	1.000
397	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCL2(3), BCR(11), CRKL(1), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAP2K4(9), MAP3K1(11), MAPK3(1), MAPK8(6), MYC(5), PIK3R1(11), RAF1(10), SOS1(7), STAT1(10), STAT5A(3), STAT5B(14)	11116734	132	72	123	33	28	38	2	24	37	3	0.0727	1.000	1.000
398	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(3), CREBBP(40), EP300(21), FYN(10), IL2RG(6), IL7(1), IL7R(9), JAK1(12), JAK3(13), LCK(4), NMI(1), PIK3R1(11), PTK2B(16), STAT5A(3), STAT5B(14)	11051291	164	72	155	35	44	44	1	32	41	2	0.0144	1.000	1.000
399	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), GORASP1(4), MAP2K4(9), MAPK1(3), MAPK10(5), MAPK11(1), MAPK12(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK5(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), PIK3CD(11), PIK3R1(11), SYT1(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6)	13169944	143	72	139	38	49	31	4	20	35	4	0.0628	1.000	1.000
400	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(2), CDKN1A(3), GNAQ(4), MARCKS(3), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SP1(6), SP3(3), SYT1(4)	9006258	122	71	117	37	46	31	3	16	26	0	0.0992	1.000	1.000
401	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(8), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), DFFA(4), DFFB(3), FADD(1), GAS2(2), LMNA(6), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), SPTAN1(20), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(5), TRADD(2), TRAF2(4)	13818875	116	71	113	36	32	28	2	26	27	1	0.472	1.000	1.000
402	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), FPGT(4), GCK(4), GMDS(2), GMPPA(6), GMPPB(6), HK1(16), HK2(10), HK3(6), KHK(2), MPI(3), PFKFB1(6), PFKFB3(7), PFKFB4(4), PFKM(3), PFKP(15), PMM1(2), PMM2(2), SORD(2), TPI1(1)	10274441	128	71	123	38	51	34	3	19	21	0	0.0707	1.000	1.000
403	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(7), CHIA(4), CHIT1(4), CMAS(7), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(4), GFPT2(5), GNE(7), GNPDA1(4), GNPDA2(6), GNPNAT1(4), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), NAGK(1), NANS(3), NPL(3), PGM3(11), PHPT1(2), RENBP(2), UAP1(5)	12309781	150	71	147	42	39	44	7	28	32	0	0.0652	1.000	1.000
404	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(3), BCL2(3), CBL(3), CFLAR(1), CRKL(1), E2F1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), IRS1(24), JAK1(12), JAK3(13), MAPK1(3), MAPK3(1), MYC(5), NMI(1), PIK3R1(11), PTPN6(4), RAF1(10), RPS6KB1(5), SHC1(7), SOCS1(1), SOCS3(3), SOS1(7), STAT5A(3), STAT5B(14), SYK(7)	14558500	164	71	154	47	40	46	2	28	46	2	0.296	1.000	1.000
405	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(3), ADCY1(19), CAP1(5), CCNB1(3), GNAI1(1), GNAS(27), GNB1(1), GNGT1(3), MAPK1(3), MAPK3(1), MYT1(19), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RPS6KA1(9), SRC(3)	8428380	130	71	124	55	50	31	1	28	20	0	0.832	1.000	1.000
406	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(3), F2RL3(3), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(18), PRKCA(5), PTGS1(12), PTK2(11), RAF1(10), SRC(3), SYK(7), TBXAS1(4)	10447613	123	71	117	50	45	24	6	29	19	0	0.716	1.000	1.000
407	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(8), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), REN(3)	10842746	114	70	112	39	31	31	4	25	22	1	0.350	1.000	1.000
408	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(4), CSNK1D(2), DRD1(3), DRD2(9), GRM1(31), PLCB1(18), PPP1CA(2), PPP1R1B(1), PPP2CA(2), PPP3CA(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6867076	115	70	110	43	38	29	1	21	26	0	0.613	1.000	1.000
409	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(17), EPHB1(23), FYN(10), ITGA1(8), ITGB1(10), L1CAM(16), LYN(5), RAP1B(6), SELP(10)	6780295	108	70	103	37	39	19	8	32	9	1	0.269	1.000	1.000
410	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CYP2C19(10), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), HADHA(4), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2)	13265815	161	70	150	44	43	45	3	31	38	1	0.126	1.000	1.000
411	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(16), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(6), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2)	9709668	134	70	126	36	35	31	3	25	37	3	0.148	1.000	1.000
412	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IFNB1(3), IKBKB(7), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL1RN(1), IRAK1(6), IRAK2(7), IRAK3(6), JUN(4), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP3K7(10), MAPK14(1), MAPK8(6), MYD88(4), NFKB1(7), NFKBIA(1), RELA(5), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3), TOLLIP(5), TRAF6(6)	12735275	141	70	138	39	41	30	5	30	32	3	0.158	1.000	1.000
413	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(29), C5(11), C6(12), C7(3), ICAM1(2), IL1A(2), IL8(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELP(10), SELPLG(7), TNF(3), VCAM1(10)	10638910	135	70	127	44	45	30	4	36	20	0	0.186	1.000	1.000
414	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(5), ADH1A(4), ADH1B(4), ADH1C(5), ADH4(2), ADH6(8), ADH7(1), ADHFE1(9), AKR1C4(6), AKR1D1(3), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), SOAT2(2), SRD5A1(3), SRD5A2(3)	9967366	144	69	135	42	30	41	5	33	34	1	0.190	1.000	1.000
415	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ABP1(16), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CNDP1(6), HAL(4), HARS(9), HDC(8), HNMT(2), MAOA(2), MAOB(3), PRPS1(3), PRPS2(3)	10050972	145	69	130	39	40	33	4	25	41	2	0.240	1.000	1.000
416	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(4), ASRGL1(2), CA1(1), CA12(1), CA13(5), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(8), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), HAL(4)	9110531	117	69	113	42	27	37	4	29	20	0	0.617	1.000	1.000
417	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG3(2), ATG5(3), ATG7(5), BECN1(7), GABARAPL1(5), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA17(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(14), PIK3R4(11), PRKAA1(6), PRKAA2(7), ULK1(16), ULK2(11)	9046370	117	69	110	30	23	23	8	32	30	1	0.222	1.000	1.000
418	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), FADD(1), IKBKB(7), IL1A(2), IL1R1(4), IRAK1(6), MAP3K1(11), MAP3K14(5), MAP3K7(10), MYD88(4), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TLR4(21), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	10426604	120	69	115	35	32	24	6	31	26	1	0.281	1.000	1.000
419	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(9), EGFR(15), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(22), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SPRY1(3), SPRY3(6), SPRY4(5), SRC(3)	10713395	120	69	115	40	32	26	3	33	26	0	0.601	1.000	1.000
420	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), BCL2(3), EGFR(15), IGF1R(16), MYC(5), POLR2A(19), PPP2CA(2), PRKCA(5), RB1(13), TEP1(29), TERF1(5), TERT(4), TNKS(19), XRCC5(10)	11763574	148	69	143	61	34	48	5	28	33	0	0.808	1.000	1.000
421	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(5), ACAT2(4), ACOT11(6), ACYP1(1), ACYP2(3), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), FN3K(3), GCDH(8), HADHA(4), ITGB1BP3(2), MYST3(28), MYST4(20), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2)	11150538	132	68	127	31	36	42	5	20	27	2	0.0219	1.000	1.000
422	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(4), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3R1(11), PPP2CA(2), RPS6(1), RPS6KB1(5), TSC1(7), TSC2(12)	10558822	114	68	110	29	31	29	4	22	26	2	0.188	1.000	1.000
423	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(19), AKT1(3), BAD(3), BAX(6), BCL2(3), CSF2RB(9), IGF1(4), IGF1R(16), IL3(1), IL3RA(5), KIT(12), KITLG(3), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), YWHAH(3)	8479948	129	67	121	52	36	38	3	23	28	1	0.703	1.000	1.000
424	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(5), GPLD1(11), PGAP1(8), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(11), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGW(3), PIGX(2), PIGZ(4)	10172108	123	67	110	36	29	29	2	25	35	3	0.428	1.000	1.000
425	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(9), CS(3), DLAT(3), DLD(4), DLST(4), FH(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), PC(15), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PDK1(3), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5)	12176274	118	67	113	50	33	31	4	22	25	3	0.915	1.000	1.000
426	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(23), ACADL(2), ACADM(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(6), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SDS(4), SUCLA2(4), SUCLG1(2), SUCLG2(5)	14214282	172	67	158	50	37	55	2	33	42	3	0.343	1.000	1.000
427	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(2), BIRC2(3), BIRC3(6), CASP3(2), CFLAR(1), FADD(1), JUN(4), MAP2K4(9), MAP3K3(8), MAP3K7(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(5), NFKBIL2(13), NR2C2(3), RALBP1(8), RIPK1(2), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	11182344	126	67	124	38	39	26	7	21	32	1	0.321	1.000	1.000
428	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(19), GNAS(27), GNB1(1), GNGT1(3), PPP2CA(2), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6605217	115	65	108	40	42	24	1	19	27	2	0.723	1.000	1.000
429	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(12), BST1(3), C9orf95(2), CD38(4), ENPP1(7), ENPP3(8), NADK(10), NADSYN1(8), NMNAT1(3), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(12), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5C3(1), NT5E(2), NUDT12(4)	9071950	100	65	95	43	24	28	5	17	25	1	0.863	1.000	1.000
430	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(15), CALM1(2), CALM2(2), CAPN2(8), CAPNS1(2), CAPNS2(2), EP300(21), HDAC1(5), HDAC2(2), MEF2D(7), NFATC1(13), NFATC2(17), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SYT1(4)	10479130	126	65	120	35	50	27	3	21	24	1	0.0599	1.000	1.000
431	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(9), AP2M1(7), ARF1(5), BAD(3), BTK(4), EEA1(13), GRASP(1), GSK3A(3), GSK3B(5), LYN(5), PDPK1(2), PFKL(5), PFKM(3), PFKP(15), PLCG1(19), PRKCE(14), PRKCZ(1), RAB5A(2), RPS6KB1(5), VAV2(12)	10720354	136	65	129	39	42	33	7	23	30	1	0.147	1.000	1.000
432	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(6), ABAT(3), ADSL(5), ADSS(5), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), CAD(18), CRAT(5), DARS(2), DDO(6), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15)	11174678	119	64	116	50	45	32	0	25	17	0	0.801	1.000	1.000
433	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(5), CBS(6), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(11), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), METTL6(3), PAPSS1(6), PAPSS2(5), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SCLY(2), SEPHS1(4), SEPHS2(2), WBSCR22(6)	10696394	113	64	106	43	31	26	6	17	32	1	0.650	1.000	1.000
434	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(3), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), CHST1(14), CHST2(14), CHST4(6), CHST6(11), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6)	5365973	97	64	94	33	50	18	1	12	16	0	0.348	1.000	1.000
435	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(2), ANXA2(3), ANXA3(1), ANXA4(3), ANXA5(3), ANXA6(2), CYP11A1(5), EDN1(3), EDNRA(4), HSD11B1(3), HSD11B2(3), PLA2G4A(6), PRL(1), PTGDR(7), PTGDS(1), PTGER2(5), PTGER4(8), PTGFR(5), PTGIS(6), PTGS1(12), PTGS2(7), S100A6(1), SCGB1A1(2), TBXAS1(4)	8457480	97	64	96	41	26	24	7	24	16	0	0.852	1.000	1.000
436	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(3), CREBBP(40), EP300(21), NCOA3(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RARA(3), RXRA(6)	8872206	125	63	120	38	40	34	2	17	30	2	0.216	1.000	1.000
437	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(9), CD2(3), CD33(6), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL3(1), IL4(1), ITGAX(13), TLR2(2), TLR4(21), TLR7(5), TLR9(16)	7990479	100	63	94	47	28	21	5	34	12	0	0.935	1.000	1.000
438	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(22), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2)	8731153	110	63	107	36	36	24	4	20	25	1	0.452	1.000	1.000
439	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(22), NAGLU(6), SPAM1(9)	8767957	103	63	102	37	33	31	5	17	16	1	0.505	1.000	1.000
440	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(40), EP300(21), LPL(7), NCOA1(17), NCOA2(22), PPARG(4), RXRA(6)	7927613	117	63	113	31	36	32	5	23	20	1	0.0731	1.000	1.000
441	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(17), APOA1(8), APOA4(5), APOC2(1), APOE(2), CETP(5), CYP7A1(6), DGAT1(3), HMGCR(7), LCAT(4), LDLR(11), LIPC(4), LPL(7), LRP1(47), SCARB1(5), SOAT1(7)	11773166	139	63	129	52	51	26	10	28	20	4	0.645	1.000	1.000
442	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(6), CARS(4), DARS(2), EPRS(12), FARS2(7), GARS(4), HARS(9), IARS(10), KARS(5), LARS(5), LARS2(7), MARS(4), MARS2(2), NARS(5), QARS(5), RARS(5), SARS(8), TARS(7), WARS(5), WARS2(10), YARS(6)	13750028	128	62	125	37	39	39	4	25	21	0	0.216	1.000	1.000
443	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	AKR1B10(6), ALOX15(7), ALOX5(10), CYP1A2(5), CYP2C18(1), CYP2C19(10), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP3A4(4), CYP3A43(4), CYP3A7(4), HSD3B7(6), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), RDH11(1), RDH12(3), RDH13(5)	10139132	110	62	109	35	36	34	5	21	14	0	0.206	1.000	1.000
444	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(7), B4GALNT1(5), GLB1(5), HEXA(2), HEXB(3), LCT(22), SLC33A1(6), ST3GAL1(4), ST3GAL2(6), ST3GAL5(3), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8)	7066627	95	62	93	40	38	16	5	18	18	0	0.852	1.000	1.000
445	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), JAK1(12), JAK3(13), JUN(4), LCK(4), MAP2K1(5), MAPK3(1), MAPK8(6), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14), SYK(7)	9999634	118	62	110	30	29	33	1	28	26	1	0.125	1.000	1.000
446	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(4), CA1(1), CA12(1), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(8), GLS2(7), GLUD1(2), GLUL(5), HAL(4)	8154405	99	62	95	39	21	33	3	22	20	0	0.814	1.000	1.000
447	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(40), EP300(21), FADD(1), HDAC3(6), IKBKB(7), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	9586705	114	62	112	35	37	29	3	19	25	1	0.256	1.000	1.000
448	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(11), CHAT(4), COMT(4), DBH(6), GAD1(7), GAD2(9), HDC(8), MAOA(2), PAH(5), PNMT(8), SLC18A3(13), TH(3), TPH1(3)	5744224	85	61	84	44	36	15	2	22	9	1	0.921	1.000	1.000
449	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(6), ELK1(3), FOS(1), GRB2(4), IL6R(2), IL6ST(6), JAK1(12), JAK2(13), JAK3(13), JUN(4), MAP2K1(5), MAPK3(1), PTPN11(6), RAF1(10), SHC1(7), SOS1(7), SRF(2), STAT3(7)	10248426	109	61	105	39	25	34	1	32	16	1	0.593	1.000	1.000
450	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(15), DDX20(4), E2F1(3), ETS1(8), ETS2(4), FOS(1), HDAC2(2), HDAC5(11), JUN(4), NCOR2(30), RBL1(11), RBL2(8), SIN3A(14), SIN3B(12)	11107755	129	60	125	44	35	23	5	30	36	0	0.717	1.000	1.000
451	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(3), ARSB(2), ARSD(4), ARSE(5), ASAH1(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(22), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(8), SMPD2(3), SPTLC1(2), SPTLC2(3), UGCG(3)	10372839	113	60	112	43	38	32	6	15	22	0	0.612	1.000	1.000
452	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKL(5), PFKM(3), PFKP(15), PGD(6), PGLS(2), PGM1(3), PGM3(11), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(2), RPE(5), RPIA(2), TALDO1(5), TKT(4), TKTL1(10), TKTL2(12)	10417105	130	60	124	41	33	41	6	22	28	0	0.183	1.000	1.000
453	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(15), EGF(9), EGFR(15), GRB2(4), MET(8), PDGFRA(15), PRKCA(5), SH3GLB1(3), SH3GLB2(7), SH3KBP1(15), SRC(3)	8346713	102	59	95	47	31	23	3	17	28	0	0.946	1.000	1.000
454	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(19), ADRB2(8), CFTR(14), GNAS(27), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5625929	99	59	94	40	38	23	0	19	19	0	0.862	1.000	1.000
455	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(17), IL13(2), IL4(1), JUNB(3), MAF(3), MAP2K3(4), MAPK14(1), NFATC1(13), NFATC2(17), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5203055	92	59	85	31	37	21	1	12	21	0	0.193	1.000	1.000
456	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UGDH(5), UGP2(7), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(13), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), XYLB(7)	11603295	111	59	108	28	19	33	3	30	26	0	0.162	1.000	1.000
457	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX1(1), GPX2(3), GPX3(2), GPX5(2), GPX6(4), GPX7(3), GSR(5), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(15), TXNDC12(1)	9412179	107	59	99	34	27	26	3	24	27	0	0.519	1.000	1.000
458	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(11), AMT(4), ATIC(6), FTCD(5), GART(9), MTFMT(1), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(4), SHMT2(9), TYMS(1)	8109297	87	59	82	30	23	18	5	15	24	2	0.391	1.000	1.000
459	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME3(4), PGK1(4), PGK2(3), PKLR(7), PKM2(6), RPE(5), RPIA(2), TKT(4), TKTL1(10), TKTL2(12), TPI1(1)	8666919	97	59	95	42	31	28	5	19	14	0	0.753	1.000	1.000
460	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), ZNRD1(1)	10075177	106	59	104	32	40	30	1	21	14	0	0.166	1.000	1.000
461	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(19), ADRB2(8), GNAS(27), PLCE1(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6367978	99	59	94	46	42	25	0	16	16	0	0.919	1.000	1.000
462	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), CHUK(4), CRADD(1), IKBKB(7), JUN(4), LTA(4), MAP2K3(4), MAP2K4(9), MAP2K6(1), MAP3K1(11), MAP3K14(5), MAP4K2(7), MAPK14(1), MAPK8(6), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	10323491	100	59	98	32	27	22	5	15	29	2	0.496	1.000	1.000
463	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(10), ACE2(8), AGT(3), AGTR1(2), AGTR2(4), ANPEP(9), CMA1(1), CPA3(1), CTSA(4), CTSG(3), ENPEP(12), LNPEP(11), MAS1(2), MME(7), NLN(6), REN(3), THOP1(4)	9073726	90	58	86	39	28	23	4	18	17	0	0.861	1.000	1.000
464	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(12), JAK2(13), JAK3(13), SOCS3(3), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), TYK2(8)	7875134	92	58	88	31	20	26	2	22	21	1	0.648	1.000	1.000
465	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(15), ABCC2(12), ABCG2(6), BCHE(18), CES1(7), CES2(8), CYP3A4(4), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3)	9818652	94	58	92	35	21	26	2	26	18	1	0.709	1.000	1.000
466	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(4), SHMT2(9), TPO(24)	5046162	77	58	74	25	23	10	5	18	19	2	0.543	1.000	1.000
467	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(6), AKR1D1(3), ARSB(2), ARSD(4), ARSE(5), CYP11B1(12), CYP11B2(5), HSD11B1(3), HSD11B2(3), HSD17B2(2), HSD17B3(1), HSD3B1(4), HSD3B2(3), SRD5A1(3), SRD5A2(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4)	11676971	101	57	100	37	32	36	3	16	14	0	0.333	1.000	1.000
468	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), ACO2(9), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), PC(15), PCK1(11), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(5)	8846734	94	57	88	31	36	21	2	14	19	2	0.360	1.000	1.000
469	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(33)	7187553	91	57	85	35	27	16	3	18	26	1	0.879	1.000	1.000
470	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(7), F2(9), F2R(3), F3(1), F5(21), F7(10), FGA(9), FGB(4), FGG(3), PROC(3), PROS1(9), SERPINC1(4), TFPI(4)	7040319	87	57	87	27	26	20	4	27	10	0	0.369	1.000	1.000
471	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(6), IARS(10), IARS2(9), ILVBL(5), LARS(5), LARS2(7), PDHA1(1), PDHA2(6), PDHB(4), VARS(16), VARS2(12)	7978229	86	57	86	31	29	22	2	21	12	0	0.616	1.000	1.000
472	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKM(3), PFKP(15), PGD(6), PGLS(2), PGM1(3), PGM3(11), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(2), RPE(5), RPIA(2), TAL1(5), TALDO1(5), TKT(4)	8776582	108	57	103	34	26	33	4	19	26	0	0.248	1.000	1.000
473	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(2), EPRS(12), FECH(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), PPOX(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4), UROD(1), UROS(4)	11715149	103	57	103	37	24	32	2	24	21	0	0.631	1.000	1.000
474	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GCNT2(2), ST3GAL6(4), ST8SIA1(7)	6941063	82	56	77	28	26	19	3	13	21	0	0.619	1.000	1.000
475	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(3), CHRNB1(4), CHRNG(4), MUSK(13), PIK3R1(11), PTK2(11), PTK2B(16), RAPSN(4), SRC(3), TERT(4), YWHAH(3)	6077439	79	55	78	28	27	16	5	14	16	1	0.528	1.000	1.000
476	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C8B(14), C9(7), MASP1(1)	8920652	102	55	93	29	31	20	5	24	21	1	0.349	1.000	1.000
477	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(11), AMT(4), ATIC(6), GART(9), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(4), SHMT2(9), TYMS(1)	7669366	81	55	76	26	21	18	5	12	24	1	0.262	1.000	1.000
478	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(6), ALDOC(5), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME2(5), ME3(4), PGK1(4), PKLR(7), PKM2(6), RPE(5), RPIA(2), TKT(4), TPI1(1)	7747581	77	54	77	34	23	25	3	15	11	0	0.756	1.000	1.000
479	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), BAD(3), GRB2(4), IGF1R(16), IRS1(24), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), RAF1(10), SHC1(7), SOS1(7), YWHAH(3)	7208112	97	54	92	31	28	27	2	14	24	2	0.417	1.000	1.000
480	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), SELE(5), SELL(4), SELP(10)	6840070	79	54	75	39	29	15	1	20	14	0	0.890	1.000	1.000
481	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), GBA3(2), LPO(9), MPO(7), PRDX1(2), PRDX2(2), PRDX5(1), PRDX6(2), TPO(24), TYR(9)	4127047	67	54	65	26	18	13	5	20	10	1	0.738	1.000	1.000
482	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(4), HSPA1A(2), IFNG(2), IFNGR1(6), IFNGR2(2), IKBKB(7), JAK2(13), LIN7A(9), NFKB1(7), NFKBIA(1), RB1(13), RELA(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), USH1C(4), WT1(3)	7437068	90	54	87	34	19	25	2	24	19	1	0.731	1.000	1.000
483	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(5), ARFGAP1(2), ARFGAP3(5), ARFGEF2(28), CLTA(2), CLTB(1), COPA(9), GBF1(18), GPLD1(11), KDELR1(2), KDELR2(1), KDELR3(3)	6976993	87	53	86	26	29	30	2	13	13	0	0.165	1.000	1.000
484	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(8), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), LMNA(6), LMNB1(4), LMNB2(6), PRF1(8)	7772192	81	53	78	24	22	19	5	14	21	0	0.449	1.000	1.000
485	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15(7), ALOX15B(3), ALOX5(10), ALOX5AP(3), DPEP1(2), GGT1(6), LTA4H(5), PLA2G2A(2), PLA2G6(6), PTGDS(1), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(4)	6445417	79	53	78	23	32	15	5	14	12	1	0.124	1.000	1.000
486	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTAP(1), MTFMT(1), MTR(13), SRM(1), TAT(5)	8894699	93	53	90	49	28	29	2	16	18	0	0.964	1.000	1.000
487	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7), MASP1(1), MASP2(6), MBL2(4)	9135788	98	52	89	31	30	20	5	18	24	1	0.527	1.000	1.000
488	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPHN(11), NSF(1), SRC(3), UBQLN1(5)	5132607	84	52	83	29	16	19	10	30	9	0	0.508	1.000	1.000
489	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(9), GBA3(2), LPO(9), MPO(7), PRDX6(2), TPO(24)	3585382	62	52	61	20	21	13	3	16	8	1	0.408	1.000	1.000
490	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4E(2), EIF4EBP1(2), GSK3B(5), IGF1(4), IGF1R(16), INPPL1(24), PDPK1(2), PIK3R1(11), PPP2CA(2), RPS6(1), RPS6KB1(5)	7140971	90	52	83	25	23	23	2	15	26	1	0.384	1.000	1.000
491	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(3), JAK1(12), JAK2(13), JAK3(13), PIAS1(12), PIAS3(7), PTPRU(22), REG1A(4), SOAT1(7)	5871529	93	52	86	30	24	24	2	16	26	1	0.725	1.000	1.000
492	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(3), IL6R(2), JAK1(12), JAK2(13), JAK3(13), PIAS3(7), PTPRU(22), REG1A(4), SRC(3), STAT3(7)	6536837	86	52	83	33	24	25	0	19	17	1	0.819	1.000	1.000
493	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(9), EGFR(15), MAP2K1(5), MAP3K1(11), MAPK14(1), NCOR2(30), RARA(3), RXRA(6), THRA(6), THRB(9)	7391765	95	51	88	41	39	20	2	15	19	0	0.830	1.000	1.000
494	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(2), RFK(1), TYR(9)	6452624	76	51	72	21	16	22	4	14	20	0	0.198	1.000	1.000
495	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1D(2), CSNK1E(8), NPAS2(11), NR1D1(5), PER1(4), PER2(15), PER3(12)	7294432	78	51	76	25	22	16	5	19	15	1	0.370	1.000	1.000
496	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), DPAGT1(4), DPM1(1), FUT8(7), MAN1A1(2), MAN1B1(6), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(11), RPN1(3), RPN2(6)	8554570	83	51	81	42	24	18	5	17	19	0	0.975	1.000	1.000
497	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(9), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(6), PLCB1(18), PLCB2(8), PRL(1), TRH(4), VIP(5)	4767984	69	51	66	26	23	14	4	17	11	0	0.692	1.000	1.000
498	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(8), AKT3(6), BPNT1(4), GRB2(4), ILK(8), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PTK2B(16), RBL2(8), SHC1(7), SOS1(7)	7470757	89	51	86	23	35	20	0	13	20	1	0.272	1.000	1.000
499	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(8), AKT3(6), CDKN1A(3), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(3), NGFR(4), NTRK1(10), PIK3CD(11), SHC1(7), SOS1(7)	5976990	74	51	71	29	28	18	1	17	10	0	0.636	1.000	1.000
500	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(8), IFNB1(3), JAK1(12), PTPRU(22), REG1A(4), STAT1(10), STAT2(10), TYK2(8)	5357141	77	51	72	25	24	19	1	11	22	0	0.606	1.000	1.000
501	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), DUSP1(2), IKBKAP(12), IKBKB(7), LTA(4), MAP3K1(11), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNFAIP3(10), TNFRSF1B(3), TRAF1(3), TRAF2(4), TRAF3(4)	9635897	87	51	84	33	28	17	3	14	24	1	0.795	1.000	1.000
502	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EGF(9), EGFR(15), FOS(1), JUN(4), MYC(5), NFKB1(7), PLCG1(19), PRKCA(5), RELA(5)	8444319	90	50	88	33	27	18	7	21	17	0	0.557	1.000	1.000
503	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNH(2), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), E2F1(3), RB1(13), RBL1(11), TFDP1(5)	6638746	73	50	70	28	15	27	2	16	13	0	0.611	1.000	1.000
504	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(22), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2)	7079699	75	50	75	28	23	16	3	13	19	1	0.749	1.000	1.000
505	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(11), DNMT1(13), MTNR1A(5), MTNR1B(6), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), TBXA2R(8)	4774797	73	50	71	39	30	20	4	14	5	0	0.834	1.000	1.000
506	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(3), IFNG(2), IFNGR1(6), JAK1(12), JAK2(13), PLA2G2A(2), PTPRU(22), REG1A(4), STAT1(10)	4913590	74	50	74	24	20	23	3	13	14	1	0.486	1.000	1.000
507	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(27), GNB1(1), GNGT1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5)	4145607	70	49	65	23	33	11	1	10	15	0	0.593	1.000	1.000
508	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(7), E2F1(3), MDM2(5), MYC(5), PIK3R1(11), POLR1A(15), POLR1B(7), POLR1C(3), POLR1D(4), RB1(13), TBX2(6), TWIST1(2)	7159385	81	49	77	31	21	22	1	11	25	1	0.713	1.000	1.000
509	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(2), C3(29), C5(11), C6(12), C7(3), C8A(5), C9(7)	7502145	87	49	79	29	27	18	5	18	18	1	0.637	1.000	1.000
510	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCND1(1), CCNE1(5), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3R1(11), RAF1(10), RB1(13), RELA(5), TFDP1(5)	7743062	83	49	80	21	17	28	2	15	20	1	0.113	1.000	1.000
511	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(7), ARG1(3), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), ODC1(3), OTC(2), PYCR1(1), SMS(5)	7505559	76	49	76	23	25	20	3	21	7	0	0.211	1.000	1.000
512	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(22), NAGLU(6)	6152305	65	48	65	30	20	18	1	13	13	0	0.863	1.000	1.000
513	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(23), ACACB(34), FASN(19), MCAT(3), OXSM(4)	6763071	83	48	80	25	23	20	4	20	15	1	0.237	1.000	1.000
514	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), PON1(2), PON2(3), PON3(2)	7742962	82	48	78	39	30	18	1	12	20	1	0.906	1.000	1.000
515	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(7), B3GAT2(6), B3GAT3(4), B4GALT7(5), CHPF(2), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST3(3), CHST7(7), CHSY1(6), DSE(6), UST(9), XYLT1(12)	5331889	81	48	79	24	38	22	2	12	7	0	0.100	1.000	1.000
516	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR7(3), CD28(2), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18R1(3), IL4(1), IL4R(3), TGFB1(3), TGFB2(6), TGFB3(8)	8207664	82	48	82	34	21	20	3	21	16	1	0.763	1.000	1.000
517	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(1), RPL10A(2), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(2), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL38(1), RPL3L(3), RPL6(2), RPL7(1), RPL8(2), RPL9(3), RPS11(2), RPS13(3), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(4), RPS6(1), RPS7(1), RPS9(1), RPSA(2)	9510507	70	47	68	27	17	25	2	10	16	0	0.803	1.000	1.000
518	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(9), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(13), MAP2K1(5), MAPK3(1), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14)	7591736	84	47	78	28	23	27	1	18	14	1	0.466	1.000	1.000
519	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(9), NTRK1(10), PIR(1), PSMA7(4), WASF1(5), WASF2(5), WASF3(13), WASL(3)	6535402	71	46	67	30	25	18	2	10	15	1	0.793	1.000	1.000
520	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), IMPA2(2), ISYNA1(4), PGM1(3), PGM3(11), TGDS(4)	5006454	64	46	63	25	21	22	2	12	7	0	0.397	1.000	1.000
521	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6)	6443426	78	46	73	23	19	21	3	11	22	2	0.306	1.000	1.000
522	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(4), IL2RG(6), IL4(1), IL4R(3), IRS1(24), JAK1(12), JAK3(13), RPS6KB1(5), SHC1(7), STAT6(3)	6338702	81	46	75	24	22	20	1	9	28	1	0.612	1.000	1.000
523	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTR(13)	7458581	80	46	77	43	26	23	2	12	17	0	0.959	1.000	1.000
524	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	12	AOX1(12), CD38(4), ENPP1(7), ENPP3(8), NADSYN1(8), NMNAT1(3), NMNAT2(1), NNMT(1), NNT(12), NT5C(1), NT5E(2)	6080969	59	46	57	27	7	15	4	15	17	1	0.928	1.000	1.000
525	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(11), PLCB1(18), PLCG1(19), PRKCA(5), VAV1(9)	4574941	65	46	62	21	20	16	2	9	17	1	0.521	1.000	1.000
526	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(38), ATR(18), CHEK1(4), CHEK2(8), YWHAH(3)	6076602	71	46	66	19	15	15	3	15	20	3	0.702	1.000	1.000
527	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), CHUK(4), IFNG(2), IKBKB(7), IL4(1), JUN(4), MAP3K1(11), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(6), NFKB1(7), NFKBIA(1), RELA(5), TNFRSF9(11), TRAF2(4)	8291564	73	45	67	19	22	10	3	13	23	2	0.346	1.000	1.000
528	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), DUSP1(2), IKBKAP(12), IKBKB(7), MAP3K1(11), MAP3K14(5), NFKB1(7), NFKBIA(1), RELA(5), TNFAIP3(10), TRAF3(4), TRAF6(6)	7779939	74	45	71	24	24	14	2	12	22	0	0.657	1.000	1.000
529	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(5), CYP51A1(8), DHCR24(3), DHCR7(6), EBP(1), FDFT1(2), FDPS(9), GGCX(4), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(1), LSS(9), MVD(2), NQO1(3), NSDHL(3), PMVK(1), SC4MOL(4), SC5DL(4), SQLE(5), TM7SF2(2), VKORC1(1)	7905200	86	45	82	27	22	21	3	18	21	1	0.475	1.000	1.000
530	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3E(2), CD3G(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(13), JUN(4), MAP2K6(1), MAPK14(1), MAPK8(6), STAT4(6), TYK2(8)	7995959	77	44	77	33	11	25	5	16	17	3	0.896	1.000	1.000
531	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(10), CD44(5), CSF1(2), FCGR3A(4), IL1B(3), IL6R(2), SELL(4), SPN(4), TGFB1(3), TGFB2(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3)	5649037	62	44	61	30	21	14	0	12	14	1	0.865	1.000	1.000
532	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(3), FUT2(1), FUT9(6), GBGT1(2), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST8SIA1(7)	4353526	51	43	49	18	25	7	1	12	6	0	0.460	1.000	1.000
533	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(7), ESR1(9), GREB1(22), HSPB2(1), MTA1(8), MTA3(2), PDZK1(2), TUBA8(5)	4688945	57	43	55	24	21	17	3	5	11	0	0.593	1.000	1.000
534	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), PGM1(3), PGM3(11), TGDS(4)	4393173	58	43	58	22	18	22	2	10	6	0	0.371	1.000	1.000
535	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3E(2), CD3G(1), CD8A(4), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1)	4615326	56	43	53	25	14	16	2	14	10	0	0.791	1.000	1.000
536	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(5), ACOX3(11), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(4), FADS2(4), FASN(19), HADHA(4), HSD17B12(4), PECR(1), SCD(1)	6118413	66	42	60	28	24	12	5	9	16	0	0.779	1.000	1.000
537	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(4), ACADS(4), ACADVL(1), ACSL1(3), ACSL3(7), ACSL4(4), CPT1A(9), CPT2(5), DCI(4), EHHADH(7), HADHA(4), PECR(1), SCP2(5), SLC25A20(2)	7219115	62	42	60	20	19	14	5	12	12	0	0.353	1.000	1.000
538	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(2), CD3G(1), FYN(10), HLA-DRA(8), LCK(4), PTPRC(19), ZAP70(14)	3489064	58	42	56	22	18	20	1	13	6	0	0.566	1.000	1.000
539	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(13), EGF(9), EGFR(15), HGS(4), RAB5A(2), TF(15), TFRC(2)	5503496	60	41	57	28	16	12	2	16	12	2	0.916	1.000	1.000
540	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(3), FUT2(1), FUT9(6), GBGT1(2), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST8SIA1(7)	4620674	49	41	47	21	23	6	2	12	6	0	0.733	1.000	1.000
541	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), HMOX1(5), IL10(2), IL10RA(5), IL10RB(2), IL1A(2), JAK1(12), STAT1(10), STAT3(7), STAT5A(3), TNF(3)	5236591	56	41	56	18	11	16	1	17	11	0	0.482	1.000	1.000
542	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(6), DLL1(15), FURIN(5), NOTCH1(27), PSEN1(3)	3968173	56	41	54	28	20	10	4	11	11	0	0.826	1.000	1.000
543	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(7), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(7), UGT1A6(1), UGT1A7(1), UGT1A9(3), UGT2B15(3), UGT2B4(4)	7488405	63	40	63	19	16	21	1	14	11	0	0.245	1.000	1.000
544	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(7), POLR2A(19), POLR2B(11), POLR2C(3), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9)	5766212	59	40	58	20	20	20	0	11	8	0	0.337	1.000	1.000
545	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(12), JAK2(13), JAK3(13), MAPK1(3), MAPK3(1), STAT3(7), TYK2(8)	5011880	57	40	56	23	12	21	0	14	9	1	0.808	1.000	1.000
546	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(3), CD28(2), CD3E(2), CD3G(1), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1)	4453020	52	40	49	25	13	15	1	13	10	0	0.876	1.000	1.000
547	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3)	3982377	56	39	55	20	21	16	4	10	5	0	0.419	1.000	1.000
548	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(19), CREM(4), FHL5(3), FSHB(1), GNAS(27), XPO1(7)	3521065	61	39	57	25	28	13	0	15	5	0	0.896	1.000	1.000
549	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3)	3982377	56	39	55	20	21	16	4	10	5	0	0.419	1.000	1.000
550	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELE(5), SELL(4)	5201509	60	39	56	29	22	14	1	13	10	0	0.770	1.000	1.000
551	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(11), CHAT(4), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(6), PEMT(1), SLC18A3(13)	2990888	47	38	47	26	18	10	0	14	5	0	0.914	1.000	1.000
552	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(2), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(2), CAMK2G(8), CAMK4(8), CAMKK1(5), CAMKK2(2), CREB1(3), SYT1(4)	4950394	51	38	50	21	15	19	4	7	6	0	0.599	1.000	1.000
553	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(19), GNAS(27), GNB1(1), GNGT1(3), PRKACA(4), PRKAR1A(3)	2861889	57	38	54	24	28	10	0	11	8	0	0.865	1.000	1.000
554	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(5), GH1(2), GHR(6), IGF1(4), IGF1R(16), PIK3R1(11), SHC1(7), SOD2(1)	4771973	55	38	54	20	10	17	2	13	12	1	0.640	1.000	1.000
555	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(8), PSMD14(1), RPN1(3), RPN2(6), UBE2A(1), UBE3A(5)	5531848	57	38	56	21	15	17	6	10	9	0	0.541	1.000	1.000
556	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(1), RANBP2(33), RANGAP1(11)	3622899	46	37	46	20	6	15	3	11	9	2	0.863	1.000	1.000
557	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(6), HLA-DRA(8), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2RA(3), IL4(1), IL4R(3)	5432805	56	37	56	23	15	13	3	12	13	0	0.739	1.000	1.000
558	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(6), HDAC9(8), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(7), YWHAH(3)	3317406	44	36	43	17	18	7	4	6	9	0	0.589	1.000	1.000
559	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(4), CD2(3), CD3E(2), CD3G(1), CXCR3(1), IFNG(2), IL12A(2), IL12B(2), IL12RB1(4), IL12RB2(11), JAK2(13), STAT4(6), TYK2(8)	5910953	59	36	59	29	7	21	4	13	12	2	0.957	1.000	1.000
560	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(6), CTH(2), GGT1(6), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), PAPSS1(6), PAPSS2(5), SCLY(2), SEPHS1(4)	5307074	49	36	47	23	16	10	2	8	13	0	0.819	1.000	1.000
561	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(8)	4493030	48	36	48	23	10	16	2	10	9	1	0.936	1.000	1.000
562	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(8)	4493030	48	36	48	23	10	16	2	10	9	1	0.936	1.000	1.000
563	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(4), KNG1(9), NOS3(10), REN(3)	4226077	45	35	42	18	13	9	3	6	13	1	0.739	1.000	1.000
564	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), NAT1(2), NAT2(5), XDH(14)	3428046	44	35	44	16	11	14	1	13	5	0	0.570	1.000	1.000
565	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(9), AFMID(3), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1)	5751981	49	35	48	21	19	17	2	4	7	0	0.587	1.000	1.000
566	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(16), ITGAM(9), ITGB2(6), SELE(5), SELL(4)	4455983	47	35	46	30	18	10	1	8	10	0	0.985	1.000	1.000
567	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), RFK(1), TYR(9)	4164477	47	35	43	14	7	14	3	9	14	0	0.448	1.000	1.000
568	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(9), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1)	5492669	46	34	45	21	17	16	2	4	7	0	0.696	1.000	1.000
569	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(6), DHRS1(2), DHRS2(1), DHRS3(2), DHRS7(6), DHRSX(5), HSD3B7(6), PON1(2), PON2(3), PON3(2), RDH11(1), RDH12(3), RDH13(5)	3863797	44	34	43	21	15	12	2	9	5	1	0.866	1.000	1.000
570	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(5), ATF3(1), CYR61(1), DUSP14(3), EIF4E(2), EIF4EBP1(2), HBEGF(1), IFNG(2), IFRD1(8), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(5), WDR1(2)	4571364	48	34	45	17	17	6	5	10	10	0	0.597	1.000	1.000
571	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(9), CS(3), FH(3), IDH2(4), MDH1(3), OGDH(11), SDHA(6), SUCLA2(4)	4045241	43	34	40	17	14	10	2	4	11	2	0.763	1.000	1.000
572	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(5), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(4), CSNK1A1(3), CSNK1D(2), GSK3B(5), MAPT(7), PPP2CA(2)	3947928	43	34	42	24	15	14	0	7	6	1	0.940	1.000	1.000
573	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3E(2), CD3G(1), GZMB(3), ICAM1(2), ITGAL(16), ITGB2(6), PRF1(8)	3328004	38	33	37	16	13	8	1	6	10	0	0.694	1.000	1.000
574	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(9), EGFR(15), NRG1(14)	3214486	38	33	37	22	14	11	3	6	4	0	0.918	1.000	1.000
575	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(5), CDO1(1), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MPST(2), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(3), SULT4A1(2)	5375393	47	33	47	21	17	15	1	8	6	0	0.775	1.000	1.000
576	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(6), MMP2(6), MMP9(17), RECK(8), TIMP2(2), TIMP3(6), TIMP4(1)	3229191	46	33	45	21	18	11	0	4	12	1	0.798	1.000	1.000
577	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL16(13), IL18(1), IL1A(2), IL3(1), IL4(1), IL8(2), LTA(4), TNF(3)	4262673	41	32	41	20	8	11	2	11	9	0	0.927	1.000	1.000
578	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(8), BCL2(3), CASP3(2), CASP9(3), DAXX(10), FAS(3), FASLG(3), HSPB2(1), IL1A(2), MAPKAPK2(1), MAPKAPK3(5), TNF(3)	4861076	47	32	46	23	16	9	0	12	9	1	0.924	1.000	1.000
579	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(5), IMPDH1(5), MTHFD2(1), POLB(4), POLD1(15), POLG(8), PRPS2(3), RRM1(5), SRM(1)	5356739	52	32	52	19	16	16	2	10	8	0	0.567	1.000	1.000
580	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(15), PIK3R1(11), WASL(3)	4806501	47	31	46	21	7	19	1	7	12	1	0.881	1.000	1.000
581	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(4), EGR1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(4), RAF1(10)	3504293	43	31	38	19	14	12	0	9	8	0	0.724	1.000	1.000
582	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(3), B3GALT2(7), B3GALT5(1), B3GNT5(10), FUT1(3), FUT2(1), FUT3(3), ST3GAL3(2), ST3GAL4(6)	3103013	37	31	34	15	16	5	0	4	12	0	0.852	1.000	1.000
583	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(6), IFNGR2(2), JAK1(12), JAK2(13), STAT1(10)	3519636	45	31	45	17	6	16	2	10	10	1	0.774	1.000	1.000
584	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(4), GNB1(1), GNGT1(3), HTR2C(6), PLCB1(18), TUB(5)	3071122	41	31	40	19	12	8	1	10	10	0	0.890	1.000	1.000
585	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), FPGS(4), GCH1(1), GGH(3), SPR(2)	2800342	36	30	35	17	21	4	0	6	5	0	0.585	1.000	1.000
586	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(7), HDC(8), PNMT(8), TH(3), TPH1(3)	2587177	35	30	34	17	15	7	2	6	4	1	0.815	1.000	1.000
587	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(10), LARS(5), LARS2(7), PDHA1(1), PDHA2(6), PDHB(4)	4295125	38	30	38	18	6	13	1	10	8	0	0.920	1.000	1.000
588	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(6), CCNA2(1), CCND1(1), CCNE1(5), CCNE2(3), CDK2(3), E2F1(3), E2F2(4), PRB1(6)	3596037	32	29	32	14	5	14	1	8	4	0	0.697	1.000	1.000
589	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(9), CKM(1), EIF4E(2), FBL(5), GPT(3), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(7)	3852606	36	29	35	15	7	9	0	12	8	0	0.907	1.000	1.000
590	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(7), HADH(3), HADHA(4), HSD17B4(6), NTAN1(5), SIRT1(6), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(3)	5090453	45	28	42	13	12	11	4	5	13	0	0.313	1.000	1.000
591	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(4), FARS2(7), GOT1(3), GOT2(2), PAH(5), TAT(5), YARS(6)	3566422	38	28	38	13	12	12	0	9	5	0	0.506	1.000	1.000
592	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(4), PTGS1(12), PTGS2(7)	2297060	34	27	34	13	12	9	1	5	7	0	0.654	1.000	1.000
593	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(11), NR0B2(3), NR1H3(6), NR1H4(5), RXRA(6)	2341435	34	27	32	15	16	4	0	6	8	0	0.713	1.000	1.000
594	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(3), FARSB(1), GOT1(3), GOT2(2), PAH(5), TAT(5), YARS(6), YARS2(2)	3735417	34	27	34	14	10	12	0	8	4	0	0.768	1.000	1.000
595	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(3), MDH1(3), ME1(2), PC(15), PDHA1(1), SLC25A1(2), SLC25A11(2)	3977681	37	27	36	15	13	9	2	5	8	0	0.742	1.000	1.000
596	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(6), TAX1BP3(2), UBE2A(1), UBE2D3(2), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(6), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(1), UBE3A(5)	4508860	37	27	37	16	17	10	0	4	6	0	0.571	1.000	1.000
597	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(5), CYP11B2(5), CYP17A1(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(3)	2971693	34	26	34	15	11	6	5	7	5	0	0.755	1.000	1.000
598	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(5), ACAT2(4), BDH1(5), HMGCS1(2), HMGCS2(3), OXCT1(8), OXCT2(3)	3087523	30	26	30	13	8	8	1	7	5	1	0.842	1.000	1.000
599	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(8)	2559650	30	25	30	12	16	3	1	6	3	1	0.489	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1E(8), PER1(4)	3629150	33	24	32	15	10	7	2	6	7	1	0.895	1.000	1.000
601	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(2), BIRC3(6), FADD(1), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	3080991	29	24	29	14	7	7	1	4	9	1	0.899	1.000	1.000
602	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(3), MYC(5), SP1(6), SP3(3), WT1(3)	2677771	25	23	25	14	6	8	0	6	5	0	0.895	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(6), EPHX2(4), HSD3B7(6), RDH11(1), RDH12(3), RDH13(5)	2060797	25	22	24	12	8	8	1	5	3	0	0.812	1.000	1.000
604	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(4), PRKCA(5), TGM2(12)	2138229	26	22	26	10	14	3	0	5	4	0	0.533	1.000	1.000
605	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(6), CDC25B(4), CDKN1A(3), CHEK1(4), NEK1(4), WEE1(4)	2941216	25	22	25	10	5	9	0	6	5	0	0.852	1.000	1.000
606	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(3), FUT1(3), FUT2(1), FUT9(6), GCNT2(2), ST8SIA1(7)	2635353	23	21	22	10	9	3	1	8	2	0	0.731	1.000	1.000
607	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), KARS(5)	2983556	25	21	25	10	5	10	1	6	3	0	0.705	1.000	1.000
608	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(6), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), SDHD(1), UQCRC1(2)	2840593	23	19	23	11	9	6	2	4	2	0	0.725	1.000	1.000
609	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), WASF1(5), WASL(3)	3482292	24	19	24	20	6	8	1	4	5	0	0.998	1.000	1.000
610	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	4	GOT1(3), GOT2(2), TAT(5), TYR(9)	1590256	19	18	18	11	4	6	1	6	2	0	0.931	1.000	1.000
611	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2)	2935234	21	17	21	11	7	8	1	2	3	0	0.859	1.000	1.000
612	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(6), ALDH1A2(5), BCMO1(4), RDH5(2)	1676358	17	16	17	15	6	2	0	5	4	0	0.998	1.000	1.000
613	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(3), FUT2(1), FUT3(3), FUT5(3), FUT6(4), ST3GAL3(2)	2191676	17	14	17	10	10	3	0	1	3	0	0.860	1.000	1.000
614	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(4), RAB27A(4), RAB4A(2), RAB5A(2), RAB6A(1)	1819759	16	11	16	13	5	6	0	2	3	0	0.967	1.000	1.000
615	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(3)	778402	8	7	8	6	4	3	0	1	0	0	0.917	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		218932	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000