Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.131 -9999.0 0.0 -0.496 10.0 10.0 IHH -0.029 0.145 -9999.0 0.0 -0.39 35.0 35.0 SHH Np/Cholesterol/GAS1 -0.011 0.084 -9999.0 0.0 -0.202 42.0 42.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.084 0.201 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.021 0.135 -9999.0 0.0 -0.422 14.0 14.0 SMO -0.033 0.131 -9999.0 0.0 -0.426 16.0 16.0 AKT1 -0.022 0.137 -9999.0 0.0 -0.474 16.0 16.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.004 0.091 -9999.0 0.0 -0.358 16.0 16.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.033 0.129 -9999.0 0.0 -0.42 16.0 16.0 STIL -0.06 0.122 0.187 6.0 -0.322 28.0 34.0 DHH N/PTCH2 0.009 0.083 -9999.0 0.0 -0.21 33.0 33.0 DHH N/PTCH1 -0.01 0.11 -9999.0 0.0 -0.339 12.0 12.0 PIK3CA 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.055 -9999.0 0.0 -0.345 6.0 6.0 PTHLH -0.043 0.17 -9999.0 0.0 -0.662 12.0 12.0 determination of left/right symmetry -0.033 0.129 -9999.0 0.0 -0.42 16.0 16.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.043 0.169 -9999.0 0.0 -0.656 12.0 12.0 IHH N/Hhip -0.074 0.171 -9999.0 0.0 -0.331 76.0 76.0 DHH N/Hhip -0.042 0.136 -9999.0 0.0 -0.267 71.0 71.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.033 0.129 -9999.0 0.0 -0.42 16.0 16.0 pancreas development -0.073 0.173 -9999.0 0.0 -0.375 67.0 67.0 HHAT 0.023 0.035 -9999.0 0.0 -0.375 2.0 2.0 PI3K 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.094 -9999.0 0.0 -0.35 18.0 18.0 somite specification -0.033 0.129 -9999.0 0.0 -0.42 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.032 0.11 -9999.0 0.0 -0.321 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.018 0.084 -9999.0 0.0 -0.175 57.0 57.0 SHH Np/Cholesterol/Megalin -0.029 0.092 -9999.0 0.0 -0.179 69.0 69.0 SHH -0.018 0.088 -9999.0 0.0 -0.264 30.0 30.0 catabolic process -0.021 0.112 -9999.0 0.0 -0.391 10.0 10.0 SMO/Vitamin D3 -0.036 0.125 -9999.0 0.0 -0.386 16.0 16.0 SHH Np/Cholesterol/Hhip -0.05 0.124 -9999.0 0.0 -0.235 78.0 78.0 LRP2 -0.031 0.123 -9999.0 0.0 -0.294 48.0 48.0 receptor-mediated endocytosis -0.053 0.126 -9999.0 0.0 -0.361 22.0 22.0 SHH Np/Cholesterol/BOC -0.01 0.085 -9999.0 0.0 -0.205 41.0 41.0 SHH Np/Cholesterol/CDO -0.004 0.074 -9999.0 0.0 -0.195 34.0 34.0 mesenchymal cell differentiation 0.05 0.124 0.233 78.0 -9999.0 0.0 78.0 mol:Vitamin D3 -0.029 0.114 0.201 6.0 -0.34 15.0 21.0 IHH N/PTCH2 -0.024 0.116 -9999.0 0.0 -0.237 56.0 56.0 CDON 0.017 0.056 -9999.0 0.0 -0.323 7.0 7.0 IHH N/PTCH1 -0.014 0.116 -9999.0 0.0 -0.395 10.0 10.0 Megalin/LRPAP1 -0.004 0.091 -9999.0 0.0 -0.202 47.0 47.0 PTCH2 -0.005 0.096 -9999.0 0.0 -0.288 28.0 28.0 SHH Np/Cholesterol -0.008 0.068 -9999.0 0.0 -0.198 30.0 30.0 PTCH1 -0.021 0.112 -9999.0 0.0 -0.393 10.0 10.0 HHIP -0.073 0.173 -9999.0 0.0 -0.375 67.0 67.0