Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.028 -9999.0 0.0 -0.192 4.0 4.0 epithelial cell differentiation 0.048 0.035 -9999.0 0.0 -0.188 4.0 4.0 CYFIP2 0.02 0.046 -9999.0 0.0 -0.353 4.0 4.0 ENAH -0.004 0.052 0.206 5.0 -0.234 1.0 6.0 EGFR 0.012 0.07 -9999.0 0.0 -0.365 9.0 9.0 EPHA2 0.023 0.031 -9999.0 0.0 -0.33 2.0 2.0 MYO6 -0.004 0.042 0.179 10.0 -9999.0 0.0 10.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.036 -9999.0 0.0 -0.207 4.0 4.0 AQP5 -0.115 0.187 -9999.0 0.0 -0.404 75.0 75.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.04 0.176 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.045 0.176 9.0 -9999.0 0.0 9.0 EGF -0.013 0.106 -9999.0 0.0 -0.302 32.0 32.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.009 0.093 -9999.0 0.0 -0.416 10.0 10.0 cortical microtubule organization 0.048 0.035 -9999.0 0.0 -0.188 4.0 4.0 GO:0000145 -0.005 0.038 0.164 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.037 -9999.0 0.0 -0.189 4.0 4.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.029 -9999.0 0.0 -0.315 1.0 1.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.039 -9999.0 0.0 -0.202 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.039 0.176 8.0 -9999.0 0.0 8.0 PVRL2 0.025 0.02 -9999.0 0.0 -0.285 1.0 1.0 ZYX -0.004 0.042 0.179 10.0 -9999.0 0.0 10.0 ARF6/GTP 0.061 0.041 -9999.0 0.0 -0.189 1.0 1.0 CDH1 0.02 0.049 -9999.0 0.0 -0.375 4.0 4.0 EGFR/EGFR/EGF/EGF 0.012 0.074 -9999.0 0.0 -0.34 1.0 1.0 RhoA/GDP 0.048 0.035 -9999.0 0.0 -0.18 3.0 3.0 actin cytoskeleton organization -0.005 0.04 0.166 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.02 0.119 -9999.0 0.0 -0.316 37.0 37.0 DIAPH1 0.009 0.147 -9999.0 0.0 -0.527 13.0 13.0 Wnt receptor signaling pathway -0.048 0.035 0.188 4.0 -9999.0 0.0 4.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.028 -9999.0 0.0 -0.299 1.0 1.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.005 0.041 0.167 10.0 -9999.0 0.0 10.0 EFNA1 0.022 0.038 -9999.0 0.0 -0.285 4.0 4.0 LPP -0.01 0.046 0.172 8.0 -0.247 2.0 10.0 Ephrin A1/EPHA2 0.037 0.044 -9999.0 0.0 -0.34 1.0 1.0 SEC6/SEC8 -0.015 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.008 0.045 0.177 9.0 -9999.0 0.0 9.0 HGF/MET 0.019 0.064 -9999.0 0.0 -0.248 1.0 1.0 HGF 0.02 0.042 -9999.0 0.0 -0.285 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.029 -9999.0 0.0 -0.193 4.0 4.0 actin cable formation 0.02 0.079 0.249 14.0 -0.345 1.0 15.0 KIAA1543 -0.004 0.04 0.167 10.0 -9999.0 0.0 10.0 KIFC3 -0.007 0.037 0.177 7.0 -9999.0 0.0 7.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.044 0.179 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.035 -9999.0 0.0 -0.188 4.0 4.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.006 0.039 0.179 8.0 -9999.0 0.0 8.0 PIP5K1C -0.005 0.041 0.177 9.0 -9999.0 0.0 9.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.002 0.067 0.309 4.0 -0.269 1.0 5.0 adherens junction assembly -0.009 0.098 0.269 2.0 -0.565 5.0 7.0 IGF-1R heterotetramer/IGF1 0.017 0.072 -9999.0 0.0 -0.294 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.019 -9999.0 0.0 -0.195 1.0 1.0 MET -0.008 0.096 -9999.0 0.0 -0.285 29.0 29.0 PLEKHA7 -0.004 0.042 0.179 10.0 -9999.0 0.0 10.0 mol:GTP 0.055 0.038 -9999.0 0.0 -0.201 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.017 0.084 0.281 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization 0.019 0.028 -9999.0 0.0 -0.192 4.0 4.0 regulation of cell-cell adhesion -0.005 0.04 0.166 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.029 -9999.0 0.0 -0.193 4.0 4.0