Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Lissencephaly gene (LIS1) in neuronal migration and development	63.0	3405.0	54.0	-0.265	0.037	1000.0	-1000.0	-0.031	-1000.0
FOXA2 and FOXA3 transcription factor networks	51.0	2348.0	46.0	-0.635	0.03	1000.0	-1000.0	-0.151	-1000.0
Aurora C signaling	38.0	272.0	7.0	-0.411	0.036	1000.0	-1000.0	-0.014	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3128.0	82.0	-0.107	0.027	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	37.0	967.0	26.0	-0.124	0.026	1000.0	-1000.0	-0.006	-1000.0
Wnt signaling	34.0	240.0	7.0	-0.069	0.022	1000.0	-1000.0	-0.016	-1000.0
Reelin signaling pathway	33.0	1867.0	56.0	-0.102	0.055	1000.0	-1000.0	-0.036	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	31.0	1078.0	34.0	-0.059	0.027	1000.0	-1000.0	-0.032	-1000.0
IL4-mediated signaling events	31.0	2835.0	91.0	-0.718	0.583	1000.0	-1000.0	-0.195	-1000.0
Fc-epsilon receptor I signaling in mast cells	30.0	2918.0	97.0	-0.099	0.033	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	30.0	2375.0	78.0	-0.203	0.059	1000.0	-1000.0	-0.065	-1000.0
p75(NTR)-mediated signaling	29.0	3740.0	125.0	-0.135	0.069	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by the Hedgehog family	26.0	1375.0	52.0	-0.074	0.05	1000.0	-1000.0	-0.053	-1000.0
Ephrin A  reverse signaling	25.0	180.0	7.0	-0.015	0.008	1000.0	-1000.0	-0.008	-1000.0
Glypican 1 network	25.0	1234.0	48.0	-0.092	0.047	1000.0	-1000.0	-0.027	-1000.0
Canonical Wnt signaling pathway	25.0	1310.0	51.0	-0.265	0.108	1000.0	-1000.0	-0.058	-1000.0
Syndecan-2-mediated signaling events	24.0	1695.0	69.0	-0.136	0.043	1000.0	-1000.0	-0.042	-1000.0
IL23-mediated signaling events	24.0	1489.0	60.0	-0.607	0.027	1000.0	-1000.0	-0.133	-1000.0
Syndecan-1-mediated signaling events	23.0	813.0	34.0	-0.106	0.027	1000.0	-1000.0	-0.035	-1000.0
Noncanonical Wnt signaling pathway	22.0	589.0	26.0	-0.069	0.026	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1360.0	61.0	-0.264	0.069	1000.0	-1000.0	-0.05	-1000.0
BMP receptor signaling	21.0	1775.0	81.0	-0.204	0.048	1000.0	-1000.0	-0.047	-1000.0
Ephrin B reverse signaling	21.0	1030.0	48.0	-0.136	0.068	1000.0	-1000.0	-0.021	-1000.0
EPHB forward signaling	20.0	1724.0	85.0	-0.136	0.101	1000.0	-1000.0	-0.059	-1000.0
Aurora B signaling	20.0	1374.0	67.0	-0.295	0.07	1000.0	-1000.0	-0.044	-1000.0
BCR signaling pathway	19.0	1915.0	99.0	-0.265	0.034	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Cones	18.0	717.0	38.0	-0.038	0.046	1000.0	-1000.0	-0.011	-1000.0
Endothelins	18.0	1781.0	96.0	-0.206	0.027	1000.0	-1000.0	-0.066	-1000.0
TCGA08_retinoblastoma	18.0	146.0	8.0	-0.047	0.031	1000.0	-1000.0	-0.002	-1000.0
amb2 Integrin signaling	17.0	1434.0	82.0	-0.131	0.04	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	17.0	1749.0	102.0	-0.117	0.036	1000.0	-1000.0	-0.064	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	16.0	861.0	52.0	-0.117	0.054	1000.0	-1000.0	-0.048	-1000.0
Glypican 2 network	16.0	66.0	4.0	0.003	0.017	1000.0	-1000.0	0.007	-1000.0
ErbB2/ErbB3 signaling events	15.0	979.0	65.0	-0.087	0.039	1000.0	-1000.0	-0.054	-1000.0
HIF-1-alpha transcription factor network	15.0	1188.0	76.0	-0.238	0.036	1000.0	-1000.0	-0.143	-1000.0
PDGFR-alpha signaling pathway	15.0	679.0	44.0	-0.249	0.214	1000.0	-1000.0	-0.049	-1000.0
TCGA08_p53	15.0	111.0	7.0	-0.04	0.026	1000.0	-1000.0	-0.009	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1467.0	93.0	-0.105	0.054	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	14.0	43.0	3.0	-0.004	-1000.0	1000.0	-1000.0	-0.015	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1703.0	120.0	-0.086	0.071	1000.0	-1000.0	-0.048	-1000.0
Visual signal transduction: Rods	13.0	684.0	52.0	-0.039	0.035	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	12.0	748.0	62.0	-0.095	0.058	1000.0	-1000.0	-0.034	-1000.0
Nongenotropic Androgen signaling	12.0	658.0	52.0	-0.031	0.042	1000.0	-1000.0	-0.038	-1000.0
Nectin adhesion pathway	11.0	724.0	63.0	-0.197	0.052	1000.0	-1000.0	-0.044	-1000.0
PLK1 signaling events	10.0	865.0	85.0	-0.026	0.045	1000.0	-1000.0	-0.036	-1000.0
Glucocorticoid receptor regulatory network	10.0	1218.0	114.0	-0.262	0.152	1000.0	-1000.0	-0.083	-1000.0
EGFR-dependent Endothelin signaling events	10.0	213.0	21.0	-0.028	0.039	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	10.0	1009.0	97.0	-0.062	0.071	1000.0	-1000.0	-0.05	-1000.0
LPA4-mediated signaling events	9.0	108.0	12.0	-0.055	0.007	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	9.0	348.0	38.0	-0.132	0.04	1000.0	-1000.0	-0.045	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	343.0	37.0	-0.116	0.061	1000.0	-1000.0	-0.032	-1000.0
Syndecan-3-mediated signaling events	9.0	325.0	35.0	-0.13	0.069	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	9.0	821.0	84.0	-0.134	0.06	1000.0	-1000.0	-0.037	-1000.0
Syndecan-4-mediated signaling events	9.0	642.0	67.0	-0.13	0.03	1000.0	-1000.0	-0.043	-1000.0
FOXM1 transcription factor network	9.0	484.0	51.0	-0.093	0.028	1000.0	-1000.0	-0.187	-1000.0
Regulation of Androgen receptor activity	9.0	691.0	70.0	-0.19	0.033	1000.0	-1000.0	-0.047	-1000.0
ErbB4 signaling events	8.0	592.0	69.0	-0.105	0.044	1000.0	-1000.0	-0.041	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	702.0	85.0	-0.04	0.034	1000.0	-1000.0	-0.049	-1000.0
Ceramide signaling pathway	8.0	663.0	76.0	-0.022	0.071	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	8.0	511.0	62.0	-0.051	0.054	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	8.0	410.0	49.0	0.0	0.039	1000.0	-1000.0	-0.033	-1000.0
FAS signaling pathway (CD95)	8.0	400.0	47.0	-0.09	0.04	1000.0	-1000.0	-0.042	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	262.0	31.0	-0.106	0.027	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	8.0	458.0	51.0	-0.276	0.073	1000.0	-1000.0	-0.054	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	550.0	68.0	-0.196	0.029	1000.0	-1000.0	-0.101	-1000.0
Plasma membrane estrogen receptor signaling	8.0	748.0	86.0	-0.047	0.05	1000.0	-1000.0	-0.045	-1000.0
Cellular roles of Anthrax toxin	7.0	278.0	39.0	-0.019	0.027	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	7.0	595.0	76.0	-0.078	0.034	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	7.0	476.0	68.0	-0.042	0.045	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	632.0	83.0	-0.265	0.052	1000.0	-1000.0	-0.038	-1000.0
S1P1 pathway	7.0	277.0	36.0	-0.03	0.027	1000.0	-1000.0	-0.041	-1000.0
IGF1 pathway	7.0	406.0	57.0	-0.023	0.052	1000.0	-1000.0	-0.043	-1000.0
Caspase cascade in apoptosis	6.0	465.0	74.0	-0.043	0.062	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	6.0	472.0	76.0	-0.048	0.046	1000.0	-1000.0	-0.019	-1000.0
IL12-mediated signaling events	6.0	563.0	87.0	-0.059	0.047	1000.0	-1000.0	-0.107	-1000.0
S1P5 pathway	6.0	112.0	17.0	-0.008	0.03	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	6.0	395.0	58.0	-0.05	0.052	1000.0	-1000.0	-0.053	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	482.0	74.0	-0.115	0.061	1000.0	-1000.0	-0.06	-1000.0
S1P4 pathway	6.0	155.0	25.0	-0.011	0.046	1000.0	-1000.0	-0.024	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	111.0	17.0	-0.002	0.043	1000.0	-1000.0	-0.03	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	86.0	17.0	-0.026	0.063	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	5.0	369.0	68.0	-0.056	0.038	1000.0	-1000.0	-0.058	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	76.0	15.0	-0.023	0.027	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	5.0	343.0	58.0	-0.126	0.049	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	5.0	308.0	54.0	-0.044	0.059	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	5.0	392.0	75.0	-0.187	0.043	1000.0	-1000.0	-0.084	-1000.0
Class I PI3K signaling events	5.0	427.0	73.0	-0.044	0.05	1000.0	-1000.0	-0.05	-1000.0
Regulation of Telomerase	5.0	552.0	102.0	-0.106	0.061	1000.0	-1000.0	-0.059	-1000.0
S1P3 pathway	5.0	211.0	42.0	-0.01	0.046	1000.0	-1000.0	-0.039	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	195.0	33.0	-0.048	0.064	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	112.0	28.0	-0.008	0.046	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	4.0	266.0	60.0	-0.035	0.052	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	210.0	44.0	-0.035	0.027	1000.0	-1000.0	-0.034	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	206.0	45.0	-0.0	0.067	1000.0	-1000.0	-0.048	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	398.0	88.0	-0.07	0.07	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by PRL	4.0	140.0	34.0	-0.042	0.039	1000.0	-1000.0	-0.037	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	4.0	182.0	44.0	-0.046	0.054	1000.0	-1000.0	-0.026	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	471.0	136.0	-0.09	0.072	1000.0	-1000.0	-0.058	-1000.0
Thromboxane A2 receptor signaling	3.0	390.0	105.0	-0.031	0.044	1000.0	-1000.0	-0.053	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	195.0	65.0	-0.048	0.062	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	3.0	214.0	55.0	0.008	0.059	1000.0	-1000.0	-0.04	-1000.0
mTOR signaling pathway	3.0	180.0	53.0	-0.032	0.038	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class III	3.0	147.0	40.0	-0.048	0.051	1000.0	-1000.0	-0.02	-1000.0
FoxO family signaling	3.0	238.0	64.0	-0.041	0.057	1000.0	-1000.0	-0.076	-1000.0
TCGA08_rtk_signaling	3.0	94.0	26.0	-0.039	0.073	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	279.0	76.0	-0.018	0.059	1000.0	-1000.0	-0.053	-1000.0
IL2 signaling events mediated by STAT5	3.0	66.0	22.0	0.005	0.038	1000.0	-1000.0	-0.047	-1000.0
Arf6 trafficking events	3.0	230.0	71.0	-0.056	0.049	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	3.0	290.0	74.0	-0.025	0.066	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling in keratinocytes	3.0	158.0	43.0	-0.028	0.043	1000.0	-1000.0	-0.04	-1000.0
Canonical NF-kappaB pathway	2.0	102.0	39.0	-0.0	0.057	1000.0	-1000.0	-0.042	-1000.0
BARD1 signaling events	2.0	116.0	57.0	-0.056	0.064	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	2.0	88.0	32.0	-0.05	0.051	1000.0	-1000.0	-0.035	-1000.0
VEGFR1 specific signals	2.0	124.0	56.0	-0.014	0.059	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	2.0	55.0	20.0	-0.008	0.033	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling events	2.0	13.0	5.0	0.02	0.042	1000.0	-1000.0	0.008	-1000.0
Signaling events mediated by HDAC Class II	1.0	111.0	75.0	-0.028	0.069	1000.0	-1000.0	-0.03	-1000.0
Circadian rhythm pathway	1.0	25.0	22.0	-0.005	0.056	1000.0	-1000.0	-0.044	-1000.0
Arf6 downstream pathway	1.0	76.0	43.0	-0.03	0.046	1000.0	-1000.0	-0.035	-1000.0
TRAIL signaling pathway	1.0	60.0	48.0	-0.0	0.056	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	1.0	54.0	43.0	-0.077	0.078	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by HDAC Class I	1.0	165.0	104.0	-0.05	0.064	1000.0	-1000.0	-0.03	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	39.0	36.0	-0.05	0.052	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	231.0	125.0	0.0	0.067	1000.0	-1000.0	-0.055	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	0.009	0.045	1000.0	-1000.0	-0.032	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.023	0.038	1000.0	-1000.0	0.008	-1000.0
Atypical NF-kappaB pathway	0.0	21.0	31.0	-0.0	0.035	1000.0	-1000.0	-0.026	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.0	0.058	1000.0	-1000.0	-0.032	-1000.0
Arf1 pathway	0.0	50.0	54.0	-0.001	0.049	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	1456	85353	7203	-12.1918562129	-992.992420861	131000	-131000	-5.70792106994	-131000