Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.149 0.279 -9999.0 0.0 -0.609 97.0 97.0 IHH -0.2 0.316 -9999.0 0.0 -0.652 143.0 143.0 SHH Np/Cholesterol/GAS1 -0.12 0.209 -9999.0 0.0 -0.432 128.0 128.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.131 0.2 0.428 128.0 -9999.0 0.0 128.0 SMO/beta Arrestin2 -0.171 0.299 -9999.0 0.0 -0.639 105.0 105.0 SMO -0.186 0.318 -9999.0 0.0 -0.624 133.0 133.0 AKT1 -0.06 0.125 -9999.0 0.0 -0.346 11.0 11.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.033 0.141 -9999.0 0.0 -0.459 42.0 42.0 ADRBK1 0.007 0.04 -9999.0 0.0 -0.466 3.0 3.0 heart looping -0.182 0.309 -9999.0 0.0 -0.603 137.0 137.0 STIL -0.179 0.294 -9999.0 0.0 -0.629 107.0 107.0 DHH N/PTCH2 -0.031 0.135 -9999.0 0.0 -0.395 51.0 51.0 DHH N/PTCH1 -0.143 0.259 -9999.0 0.0 -0.561 93.0 93.0 PIK3CA 0.009 0.018 -9999.0 0.0 -0.373 1.0 1.0 DHH -0.032 0.157 -9999.0 0.0 -0.607 31.0 31.0 PTHLH -0.207 0.375 -9999.0 0.0 -0.855 95.0 95.0 determination of left/right symmetry -0.182 0.309 -9999.0 0.0 -0.603 137.0 137.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.204 0.369 -9999.0 0.0 -0.843 95.0 95.0 IHH N/Hhip -0.23 0.296 -9999.0 0.0 -0.525 201.0 201.0 DHH N/Hhip -0.128 0.221 -9999.0 0.0 -0.43 147.0 147.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.182 0.309 -9999.0 0.0 -0.603 137.0 137.0 pancreas development -0.143 0.261 -9999.0 0.0 -0.558 123.0 123.0 HHAT -0.015 0.126 -9999.0 0.0 -0.637 18.0 18.0 PI3K 0.014 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.063 0.189 -9999.0 0.0 -0.519 63.0 63.0 somite specification -0.182 0.309 -9999.0 0.0 -0.603 137.0 137.0 SHH Np/Cholesterol/PTCH1 -0.188 0.305 -9999.0 0.0 -0.652 110.0 110.0 SHH Np/Cholesterol/PTCH2 -0.091 0.185 -9999.0 0.0 -0.412 100.0 100.0 SHH Np/Cholesterol/Megalin -0.133 0.204 -9999.0 0.0 -0.417 135.0 135.0 SHH -0.108 0.225 -9999.0 0.0 -0.513 100.0 100.0 catabolic process -0.139 0.254 -9999.0 0.0 -0.505 124.0 124.0 SMO/Vitamin D3 -0.207 0.332 -9999.0 0.0 -0.693 118.0 118.0 SHH Np/Cholesterol/Hhip -0.165 0.254 -9999.0 0.0 -0.49 147.0 147.0 LRP2 -0.084 0.202 -9999.0 0.0 -0.486 86.0 86.0 receptor-mediated endocytosis -0.242 0.304 -9999.0 0.0 -0.675 122.0 122.0 SHH Np/Cholesterol/BOC -0.103 0.193 -9999.0 0.0 -0.417 108.0 108.0 SHH Np/Cholesterol/CDO -0.093 0.188 -9999.0 0.0 -0.412 105.0 105.0 mesenchymal cell differentiation 0.174 0.244 0.485 147.0 -9999.0 0.0 147.0 mol:Vitamin D3 -0.187 0.308 -9999.0 0.0 -0.655 110.0 110.0 IHH N/PTCH2 -0.133 0.213 -9999.0 0.0 -0.439 140.0 140.0 CDON -0.014 0.109 -9999.0 0.0 -0.47 23.0 23.0 IHH N/PTCH1 -0.14 0.258 -9999.0 0.0 -0.512 124.0 124.0 Megalin/LRPAP1 -0.053 0.149 -9999.0 0.0 -0.345 86.0 86.0 PTCH2 -0.011 0.094 -9999.0 0.0 -0.409 23.0 23.0 SHH Np/Cholesterol -0.095 0.174 -9999.0 0.0 -0.41 99.0 99.0 PTCH1 -0.139 0.255 -9999.0 0.0 -0.507 124.0 124.0 HHIP -0.143 0.261 -9999.0 0.0 -0.559 123.0 123.0