Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.072 -9999.0 0.0 -0.309 21.0 21.0 epithelial cell differentiation -0.016 0.076 -9999.0 0.0 -0.362 20.0 20.0 CYFIP2 -0.013 0.118 -9999.0 0.0 -0.603 17.0 17.0 ENAH 0.029 0.082 -9999.0 0.0 -0.456 6.0 6.0 EGFR -0.036 0.142 -9999.0 0.0 -0.445 46.0 46.0 EPHA2 -0.006 0.101 -9999.0 0.0 -0.652 11.0 11.0 MYO6 0.01 0.085 -9999.0 0.0 -0.357 22.0 22.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.077 -9999.0 0.0 -0.422 15.0 15.0 AQP5 -0.173 0.231 -9999.0 0.0 -0.524 131.0 131.0 CTNND1 0.009 0.031 -9999.0 0.0 -0.652 1.0 1.0 mol:PI-4-5-P2 0.013 0.076 -9999.0 0.0 -0.337 20.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.135 -9999.0 0.0 -0.336 71.0 71.0 EGF -0.142 0.235 -9999.0 0.0 -0.472 144.0 144.0 NCKAP1 0.009 0.031 -9999.0 0.0 -0.652 1.0 1.0 AQP3 -0.039 0.114 -9999.0 0.0 -0.539 17.0 17.0 cortical microtubule organization -0.016 0.076 -9999.0 0.0 -0.362 20.0 20.0 GO:0000145 0.012 0.073 -9999.0 0.0 -0.322 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.076 -9999.0 0.0 -0.366 20.0 20.0 MLLT4 0.009 0.031 -9999.0 0.0 -0.652 1.0 1.0 ARF6/GDP -0.021 0.092 -9999.0 0.0 -0.632 6.0 6.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.011 0.068 -9999.0 0.0 -0.397 13.0 13.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.019 0.079 -9999.0 0.0 -0.466 4.0 4.0 PVRL2 0.008 0.025 -9999.0 0.0 -0.373 2.0 2.0 ZYX 0.012 0.079 -9999.0 0.0 -0.342 21.0 21.0 ARF6/GTP -0.01 0.062 -9999.0 0.0 -0.364 13.0 13.0 CDH1 -0.016 0.129 -9999.0 0.0 -0.652 18.0 18.0 EGFR/EGFR/EGF/EGF -0.098 0.143 -9999.0 0.0 -0.336 95.0 95.0 RhoA/GDP -0.015 0.071 -9999.0 0.0 -0.339 20.0 20.0 actin cytoskeleton organization 0.015 0.082 -9999.0 0.0 -0.341 20.0 20.0 IGF-1R heterotetramer -0.009 0.105 -9999.0 0.0 -0.546 16.0 16.0 GIT1 0.009 0.031 -9999.0 0.0 -0.652 1.0 1.0 IGF1R -0.01 0.105 -9999.0 0.0 -0.547 16.0 16.0 IGF1 -0.088 0.21 -9999.0 0.0 -0.5 88.0 88.0 DIAPH1 -0.024 0.12 -9999.0 0.0 -0.649 16.0 16.0 Wnt receptor signaling pathway 0.016 0.076 0.362 20.0 -9999.0 0.0 20.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.092 -9999.0 0.0 -0.633 6.0 6.0 CTNNA1 0.007 0.044 -9999.0 0.0 -0.652 2.0 2.0 VCL 0.015 0.084 -9999.0 0.0 -0.35 20.0 20.0 EFNA1 0.007 0.044 -9999.0 0.0 -0.652 2.0 2.0 LPP 0.015 0.085 -9999.0 0.0 -0.353 21.0 21.0 Ephrin A1/EPHA2 -0.023 0.107 -9999.0 0.0 -0.41 26.0 26.0 SEC6/SEC8 -0.014 0.064 -9999.0 0.0 -0.586 1.0 1.0 MGAT3 -0.03 0.137 -9999.0 0.0 -0.341 71.0 71.0 HGF/MET -0.036 0.101 -9999.0 0.0 -0.337 41.0 41.0 HGF -0.028 0.146 -9999.0 0.0 -0.553 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.072 -9999.0 0.0 -0.311 21.0 21.0 actin cable formation 0.039 0.075 -9999.0 0.0 -0.379 6.0 6.0 KIAA1543 0.003 0.098 -9999.0 0.0 -0.357 29.0 29.0 KIFC3 0.01 0.082 -9999.0 0.0 -0.341 23.0 23.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.012 0.079 -9999.0 0.0 -0.351 20.0 20.0 NCK1/GIT1 0.014 0.023 -9999.0 0.0 -0.482 1.0 1.0 mol:GDP -0.016 0.076 -9999.0 0.0 -0.362 20.0 20.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.013 0.077 -9999.0 0.0 -0.343 20.0 20.0 PIP5K1C 0.013 0.077 -9999.0 0.0 -0.343 20.0 20.0 LIMA1 0.007 0.044 -9999.0 0.0 -0.652 2.0 2.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.026 0.089 -9999.0 0.0 -0.527 6.0 6.0 adherens junction assembly 0.013 0.101 -9999.0 0.0 -0.508 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.066 0.137 -9999.0 0.0 -0.38 52.0 52.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.029 -9999.0 0.0 -0.482 1.0 1.0 MET -0.002 0.073 -9999.0 0.0 -0.416 13.0 13.0 PLEKHA7 0.003 0.102 -9999.0 0.0 -0.374 29.0 29.0 mol:GTP -0.011 0.067 -9999.0 0.0 -0.394 13.0 13.0 establishment of epithelial cell apical/basal polarity 0.031 0.071 -9999.0 0.0 -0.558 1.0 1.0 cortical actin cytoskeleton stabilization 0.009 0.072 -9999.0 0.0 -0.309 21.0 21.0 regulation of cell-cell adhesion 0.015 0.082 -9999.0 0.0 -0.341 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.072 -9999.0 0.0 -0.311 21.0 21.0