Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.064 0.176 -9999.0 0.0 -0.573 29.0 29.0 IHH -0.104 0.237 -9999.0 0.0 -0.496 117.0 117.0 SHH Np/Cholesterol/GAS1 -0.053 0.14 -9999.0 0.0 -0.293 108.0 108.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.139 0.291 108.0 -9999.0 0.0 108.0 SMO/beta Arrestin2 -0.106 0.227 -9999.0 0.0 -0.461 95.0 95.0 SMO -0.121 0.228 -9999.0 0.0 -0.464 107.0 107.0 AKT1 -0.057 0.152 -9999.0 0.0 -0.519 27.0 27.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.086 -9999.0 0.0 -0.477 13.0 13.0 ADRBK1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.118 0.224 -9999.0 0.0 -0.457 107.0 107.0 STIL -0.106 0.192 -9999.0 0.0 -0.468 71.0 71.0 DHH N/PTCH2 0.019 0.092 -9999.0 0.0 -0.345 27.0 27.0 DHH N/PTCH1 -0.066 0.178 -9999.0 0.0 -0.315 134.0 134.0 PIK3CA 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.0 0.115 -9999.0 0.0 -0.477 25.0 25.0 PTHLH -0.103 0.248 -9999.0 0.0 -0.827 32.0 32.0 determination of left/right symmetry -0.118 0.224 -9999.0 0.0 -0.457 107.0 107.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.102 0.246 -9999.0 0.0 -0.817 32.0 32.0 IHH N/Hhip -0.104 0.227 -9999.0 0.0 -0.408 149.0 149.0 DHH N/Hhip -0.043 0.168 -9999.0 0.0 -0.358 98.0 98.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.118 0.224 -9999.0 0.0 -0.457 107.0 107.0 pancreas development -0.054 0.191 -9999.0 0.0 -0.476 77.0 77.0 HHAT 0.009 0.093 -9999.0 0.0 -0.477 16.0 16.0 PI3K 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.128 -9999.0 0.0 -0.477 31.0 31.0 somite specification -0.118 0.224 -9999.0 0.0 -0.457 107.0 107.0 SHH Np/Cholesterol/PTCH1 -0.1 0.197 -9999.0 0.0 -0.377 123.0 123.0 SHH Np/Cholesterol/PTCH2 -0.038 0.129 -9999.0 0.0 -0.29 88.0 88.0 SHH Np/Cholesterol/Megalin -0.056 0.144 -9999.0 0.0 -0.291 115.0 115.0 SHH -0.078 0.145 -9999.0 0.0 -0.369 86.0 86.0 catabolic process -0.07 0.171 -9999.0 0.0 -0.322 128.0 128.0 SMO/Vitamin D3 -0.121 0.225 -9999.0 0.0 -0.481 98.0 98.0 SHH Np/Cholesterol/Hhip -0.081 0.179 -9999.0 0.0 -0.343 130.0 130.0 LRP2 -0.006 0.137 -9999.0 0.0 -0.477 35.0 35.0 receptor-mediated endocytosis -0.136 0.228 -9999.0 0.0 -0.521 88.0 88.0 SHH Np/Cholesterol/BOC -0.04 0.133 -9999.0 0.0 -0.298 88.0 88.0 SHH Np/Cholesterol/CDO -0.039 0.13 -9999.0 0.0 -0.292 89.0 89.0 mesenchymal cell differentiation 0.08 0.178 0.34 130.0 -9999.0 0.0 130.0 mol:Vitamin D3 -0.096 0.202 0.232 1.0 -0.448 82.0 83.0 IHH N/PTCH2 -0.046 0.155 -9999.0 0.0 -0.31 113.0 113.0 CDON 0.021 0.059 -9999.0 0.0 -0.477 6.0 6.0 IHH N/PTCH1 -0.062 0.177 -9999.0 0.0 -0.325 128.0 128.0 Megalin/LRPAP1 0.013 0.104 -9999.0 0.0 -0.346 34.0 34.0 PTCH2 0.028 0.035 -9999.0 0.0 -0.477 2.0 2.0 SHH Np/Cholesterol -0.044 0.121 -9999.0 0.0 -0.284 87.0 87.0 PTCH1 -0.071 0.171 -9999.0 0.0 -0.323 127.0 127.0 HHIP -0.054 0.191 -9999.0 0.0 -0.477 77.0 77.0