Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.004 0.063 -9999.0 0.0 -0.216 30.0 30.0 epithelial cell differentiation 0.039 0.063 -9999.0 0.0 -0.27 15.0 15.0 CYFIP2 0.014 0.078 -9999.0 0.0 -0.477 11.0 11.0 ENAH -0.019 0.075 0.246 4.0 -0.403 4.0 8.0 EGFR 0.015 0.078 -9999.0 0.0 -0.477 11.0 11.0 EPHA2 0.018 0.066 -9999.0 0.0 -0.477 8.0 8.0 MYO6 -0.018 0.066 0.192 4.0 -0.275 17.0 21.0 CTNNB1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.057 -9999.0 0.0 -0.296 11.0 11.0 AQP5 -0.113 0.216 0.255 1.0 -0.458 120.0 121.0 CTNND1 0.026 0.024 -9999.0 0.0 -0.477 1.0 1.0 mol:PI-4-5-P2 -0.017 0.059 0.191 2.0 -0.259 15.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.089 0.177 13.0 -0.248 61.0 74.0 EGF -0.016 0.16 -9999.0 0.0 -0.477 48.0 48.0 NCKAP1 0.026 0.024 -9999.0 0.0 -0.477 1.0 1.0 AQP3 -0.011 0.099 0.248 1.0 -0.471 13.0 14.0 cortical microtubule organization 0.039 0.063 -9999.0 0.0 -0.27 15.0 15.0 GO:0000145 -0.017 0.055 0.183 2.0 -0.248 15.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.044 0.065 -9999.0 0.0 -0.273 15.0 15.0 MLLT4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.062 -9999.0 0.0 -0.295 19.0 19.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.058 -9999.0 0.0 -0.3 9.0 9.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.009 0.051 0.181 2.0 -0.245 11.0 13.0 PVRL2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.017 0.06 0.189 3.0 -0.263 15.0 18.0 ARF6/GTP 0.058 0.058 -9999.0 0.0 -0.286 8.0 8.0 CDH1 0.01 0.09 -9999.0 0.0 -0.477 15.0 15.0 EGFR/EGFR/EGF/EGF 0.0 0.113 -9999.0 0.0 -0.262 61.0 61.0 RhoA/GDP 0.04 0.061 -9999.0 0.0 -0.26 14.0 14.0 actin cytoskeleton organization -0.02 0.062 0.174 4.0 -0.268 17.0 21.0 IGF-1R heterotetramer 0.016 0.074 -9999.0 0.0 -0.476 10.0 10.0 GIT1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.016 0.074 -9999.0 0.0 -0.477 10.0 10.0 IGF1 -0.012 0.145 -9999.0 0.0 -0.477 40.0 40.0 DIAPH1 -0.001 0.175 -9999.0 0.0 -0.578 23.0 23.0 Wnt receptor signaling pathway -0.039 0.063 0.27 15.0 -9999.0 0.0 15.0 RHOA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.037 0.062 -9999.0 0.0 -0.295 19.0 19.0 CTNNA1 0.025 0.025 -9999.0 0.0 -0.477 1.0 1.0 VCL -0.021 0.063 0.175 4.0 -0.274 17.0 21.0 EFNA1 0.025 0.034 -9999.0 0.0 -0.477 2.0 2.0 LPP -0.02 0.052 0.178 2.0 -0.253 14.0 16.0 Ephrin A1/EPHA2 0.027 0.084 -9999.0 0.0 -0.323 19.0 19.0 SEC6/SEC8 -0.029 0.043 -9999.0 0.0 -0.253 14.0 14.0 MGAT3 -0.043 0.09 0.178 13.0 -0.251 61.0 74.0 HGF/MET 0.019 0.083 -9999.0 0.0 -0.257 33.0 33.0 HGF 0.008 0.099 -9999.0 0.0 -0.477 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.004 0.064 -9999.0 0.0 -0.218 30.0 30.0 actin cable formation 0.01 0.097 0.278 19.0 -0.294 9.0 28.0 KIAA1543 -0.022 0.069 0.165 17.0 -0.268 23.0 40.0 KIFC3 -0.021 0.06 0.192 2.0 -0.261 18.0 20.0 NCK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.06 0.189 3.0 -0.262 15.0 18.0 NCK1/GIT1 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.039 0.063 -9999.0 0.0 -0.27 15.0 15.0 EXOC4 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.06 0.189 3.0 -0.263 15.0 18.0 PIP5K1C -0.018 0.06 0.192 2.0 -0.263 15.0 17.0 LIMA1 0.026 0.024 -9999.0 0.0 -0.477 1.0 1.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.089 0.291 6.0 -0.44 4.0 10.0 adherens junction assembly -0.027 0.103 0.252 3.0 -0.447 13.0 16.0 IGF-1R heterotetramer/IGF1 0.007 0.108 -9999.0 0.0 -0.271 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.034 -9999.0 0.0 -0.477 2.0 2.0 PLEKHA7 -0.022 0.073 0.177 17.0 -0.28 23.0 40.0 mol:GTP 0.051 0.058 -9999.0 0.0 -0.298 9.0 9.0 establishment of epithelial cell apical/basal polarity 0.007 0.1 0.311 17.0 -0.426 1.0 18.0 cortical actin cytoskeleton stabilization 0.004 0.063 -9999.0 0.0 -0.216 30.0 30.0 regulation of cell-cell adhesion -0.02 0.062 0.174 4.0 -0.268 17.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.004 0.064 -9999.0 0.0 -0.218 30.0 30.0