Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	87.0	4037.0	46.0	-0.428	0.028	1000.0	-1000.0	-0.106	-1000.0
Signaling events mediated by the Hedgehog family	68.0	3579.0	52.0	-0.136	0.08	1000.0	-1000.0	-0.037	-1000.0
IL4-mediated signaling events	68.0	6236.0	91.0	-0.649	0.5	1000.0	-1000.0	-0.117	-1000.0
Ephrin A  reverse signaling	52.0	366.0	7.0	-0.055	-0.0	1000.0	-1000.0	-0.019	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	51.0	1742.0	34.0	-0.051	0.027	1000.0	-1000.0	-0.034	-1000.0
IL23-mediated signaling events	49.0	2992.0	60.0	-0.303	0.028	1000.0	-1000.0	-0.088	-1000.0
p75(NTR)-mediated signaling	39.0	4956.0	125.0	-0.079	0.069	1000.0	-1000.0	-0.063	-1000.0
Endothelins	35.0	3405.0	96.0	-0.103	0.057	1000.0	-1000.0	-0.051	-1000.0
Fc-epsilon receptor I signaling in mast cells	33.0	3263.0	97.0	-0.07	0.041	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	33.0	3092.0	93.0	-0.068	0.04	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	32.0	1555.0	48.0	-0.082	0.041	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	32.0	1443.0	44.0	-0.046	0.03	1000.0	-1000.0	-0.025	-1000.0
Wnt signaling	32.0	224.0	7.0	-0.049	0.02	1000.0	-1000.0	-0.012	-1000.0
Glucocorticoid receptor regulatory network	31.0	3578.0	114.0	-0.314	0.13	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	30.0	802.0	26.0	-0.055	0.027	1000.0	-1000.0	-0.04	-1000.0
HIF-1-alpha transcription factor network	30.0	2307.0	76.0	-0.125	0.035	1000.0	-1000.0	-0.077	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	30.0	2097.0	68.0	-0.137	0.047	1000.0	-1000.0	-0.066	-1000.0
TCGA08_retinoblastoma	29.0	238.0	8.0	-0.023	0.036	1000.0	-1000.0	-0.003	-1000.0
Reelin signaling pathway	28.0	1612.0	56.0	-0.041	0.067	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	28.0	2334.0	82.0	-0.049	0.028	1000.0	-1000.0	-0.061	-1000.0
BCR signaling pathway	28.0	2841.0	99.0	-0.11	0.036	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	26.0	2289.0	87.0	-0.118	0.038	1000.0	-1000.0	-0.068	-1000.0
BMP receptor signaling	26.0	2173.0	81.0	-0.084	0.049	1000.0	-1000.0	-0.034	-1000.0
Effects of Botulinum toxin	26.0	698.0	26.0	-0.067	0.027	1000.0	-1000.0	-0.016	-1000.0
Syndecan-1-mediated signaling events	25.0	866.0	34.0	-0.058	0.027	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Cones	25.0	975.0	38.0	-0.057	0.039	1000.0	-1000.0	-0.023	-1000.0
EPHB forward signaling	25.0	2174.0	85.0	-0.053	0.073	1000.0	-1000.0	-0.058	-1000.0
IGF1 pathway	25.0	1451.0	57.0	-0.043	0.053	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	24.0	932.0	38.0	-0.051	0.035	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	24.0	1300.0	54.0	-0.053	0.038	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	24.0	1177.0	48.0	-0.046	0.03	1000.0	-1000.0	-0.026	-1000.0
Canonical Wnt signaling pathway	24.0	1224.0	51.0	-0.093	0.142	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	23.0	2447.0	105.0	-0.055	0.032	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	22.0	1304.0	58.0	-0.074	0.051	1000.0	-1000.0	-0.033	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	683.0	31.0	-0.058	0.028	1000.0	-1000.0	-0.04	-1000.0
EGFR-dependent Endothelin signaling events	22.0	479.0	21.0	-0.041	0.04	1000.0	-1000.0	-0.043	-1000.0
Visual signal transduction: Rods	22.0	1193.0	52.0	-0.069	0.038	1000.0	-1000.0	-0.03	-1000.0
amb2 Integrin signaling	21.0	1752.0	82.0	-0.063	0.036	1000.0	-1000.0	-0.037	-1000.0
LPA receptor mediated events	21.0	2171.0	102.0	-0.057	0.037	1000.0	-1000.0	-0.071	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2524.0	120.0	-0.067	0.07	1000.0	-1000.0	-0.04	-1000.0
ErbB2/ErbB3 signaling events	20.0	1333.0	65.0	-0.037	0.04	1000.0	-1000.0	-0.049	-1000.0
Syndecan-4-mediated signaling events	19.0	1296.0	67.0	-0.03	0.037	1000.0	-1000.0	-0.035	-1000.0
IL27-mediated signaling events	18.0	921.0	51.0	-0.119	0.033	1000.0	-1000.0	-0.058	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	18.0	1347.0	74.0	-0.113	0.058	1000.0	-1000.0	-0.056	-1000.0
Caspase cascade in apoptosis	17.0	1262.0	74.0	-0.07	0.048	1000.0	-1000.0	-0.043	-1000.0
Arf6 signaling events	17.0	1082.0	62.0	-0.03	0.053	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	17.0	874.0	51.0	-0.026	0.049	1000.0	-1000.0	-0.133	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	17.0	1364.0	78.0	-0.06	0.031	1000.0	-1000.0	-0.067	-1000.0
ErbB4 signaling events	16.0	1157.0	69.0	-0.05	0.039	1000.0	-1000.0	-0.038	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	1009.0	61.0	-0.093	0.07	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	16.0	1013.0	63.0	-0.026	0.053	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1383.0	86.0	-0.055	0.047	1000.0	-1000.0	-0.05	-1000.0
Ceramide signaling pathway	15.0	1164.0	76.0	-0.032	0.073	1000.0	-1000.0	-0.033	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	15.0	810.0	52.0	-0.019	0.055	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	15.0	565.0	36.0	-0.057	0.027	1000.0	-1000.0	-0.027	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.011	0.011	1000.0	-1000.0	-0.015	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	244.0	17.0	-0.036	0.049	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PTP1B	14.0	1122.0	76.0	-0.054	0.034	1000.0	-1000.0	-0.028	-1000.0
Syndecan-2-mediated signaling events	13.0	942.0	69.0	-0.027	0.043	1000.0	-1000.0	-0.043	-1000.0
PLK1 signaling events	13.0	1111.0	85.0	-0.011	0.044	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	13.0	913.0	68.0	-0.033	0.044	1000.0	-1000.0	-0.052	-1000.0
IL1-mediated signaling events	13.0	843.0	62.0	-0.03	0.05	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	13.0	53.0	4.0	0.016	0.022	1000.0	-1000.0	0.013	-1000.0
PDGFR-beta signaling pathway	13.0	1287.0	97.0	-0.078	0.059	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	13.0	569.0	43.0	-0.021	0.029	1000.0	-1000.0	-0.03	-1000.0
Ras signaling in the CD4+ TCR pathway	13.0	230.0	17.0	-0.011	0.042	1000.0	-1000.0	-0.019	-1000.0
Cellular roles of Anthrax toxin	12.0	483.0	39.0	-0.02	0.027	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	12.0	835.0	65.0	-0.233	0.064	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	12.0	582.0	47.0	-0.071	0.04	1000.0	-1000.0	-0.04	-1000.0
Nongenotropic Androgen signaling	12.0	668.0	52.0	-0.018	0.041	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events	12.0	903.0	73.0	-0.035	0.038	1000.0	-1000.0	-0.044	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	965.0	85.0	-0.019	0.042	1000.0	-1000.0	-0.042	-1000.0
ceramide signaling pathway	11.0	546.0	49.0	-0.016	0.04	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	11.0	77.0	7.0	-0.01	0.027	1000.0	-1000.0	-0.012	-1000.0
IL2 signaling events mediated by PI3K	11.0	664.0	58.0	-0.084	0.039	1000.0	-1000.0	-0.041	-1000.0
Integrins in angiogenesis	11.0	953.0	84.0	-0.053	0.059	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	11.0	505.0	45.0	-0.021	0.06	1000.0	-1000.0	-0.041	-1000.0
S1P4 pathway	11.0	277.0	25.0	-0.013	0.045	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling events	11.0	56.0	5.0	0.01	0.029	1000.0	-1000.0	0.015	-1000.0
Regulation of Androgen receptor activity	11.0	797.0	70.0	-0.208	0.033	1000.0	-1000.0	-0.042	-1000.0
Aurora B signaling	11.0	770.0	67.0	-0.141	0.065	1000.0	-1000.0	-0.035	-1000.0
LPA4-mediated signaling events	10.0	130.0	12.0	-0.032	0.011	1000.0	-1000.0	-0.023	-1000.0
Coregulation of Androgen receptor activity	10.0	810.0	76.0	-0.161	0.052	1000.0	-1000.0	-0.023	-1000.0
S1P5 pathway	10.0	174.0	17.0	-0.004	0.036	1000.0	-1000.0	-0.012	-1000.0
Regulation of p38-alpha and p38-beta	10.0	560.0	54.0	-0.048	0.06	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in the nascent adherens junction	10.0	830.0	76.0	-0.023	0.048	1000.0	-1000.0	-0.054	-1000.0
Angiopoietin receptor Tie2-mediated signaling	10.0	946.0	88.0	-0.036	0.037	1000.0	-1000.0	-0.076	-1000.0
EPO signaling pathway	9.0	532.0	55.0	-0.001	0.061	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events mediated by Akt	9.0	625.0	68.0	-0.029	0.046	1000.0	-1000.0	-0.031	-1000.0
Syndecan-3-mediated signaling events	9.0	346.0	35.0	-0.027	0.069	1000.0	-1000.0	-0.023	-1000.0
IL6-mediated signaling events	9.0	696.0	75.0	-0.043	0.05	1000.0	-1000.0	-0.059	-1000.0
mTOR signaling pathway	8.0	471.0	53.0	-0.03	0.04	1000.0	-1000.0	-0.036	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	296.0	37.0	-0.023	0.057	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	133.0	15.0	-0.016	0.026	1000.0	-1000.0	-0.032	-1000.0
S1P3 pathway	8.0	353.0	42.0	-0.016	0.042	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1034.0	136.0	-0.176	0.07	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	7.0	311.0	43.0	-0.09	0.092	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	615.0	83.0	-0.052	0.052	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by STAT5	7.0	157.0	22.0	-0.011	0.03	1000.0	-1000.0	-0.041	-1000.0
Regulation of Telomerase	7.0	800.0	102.0	-0.062	0.061	1000.0	-1000.0	-0.043	-1000.0
Insulin Pathway	7.0	519.0	74.0	-0.036	0.064	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PRL	7.0	269.0	34.0	-0.065	0.04	1000.0	-1000.0	-0.038	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	185.0	28.0	-0.016	0.048	1000.0	-1000.0	-0.021	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	32.0	5.0	0.019	0.033	1000.0	-1000.0	0.014	-1000.0
Arf6 downstream pathway	6.0	274.0	43.0	-0.023	0.046	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class III	6.0	246.0	40.0	-0.05	0.051	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	223.0	33.0	-0.018	0.064	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	5.0	333.0	64.0	-0.039	0.049	1000.0	-1000.0	-0.06	-1000.0
Paxillin-dependent events mediated by a4b1	5.0	187.0	36.0	-0.044	0.051	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	748.0	125.0	-0.022	0.057	1000.0	-1000.0	-0.048	-1000.0
TCGA08_rtk_signaling	5.0	152.0	26.0	-0.045	0.08	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.017	-1000.0	1000.0	-1000.0	-0.024	-1000.0
Aurora A signaling	4.0	243.0	60.0	-0.017	0.053	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	4.0	30.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.01	-1000.0
p38 MAPK signaling pathway	4.0	181.0	44.0	-0.016	0.058	1000.0	-1000.0	-0.032	-1000.0
BARD1 signaling events	3.0	196.0	57.0	-0.049	0.062	1000.0	-1000.0	-0.043	-1000.0
Insulin-mediated glucose transport	3.0	109.0	32.0	-0.016	0.051	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	3.0	171.0	44.0	-0.029	0.066	1000.0	-1000.0	-0.044	-1000.0
TRAIL signaling pathway	3.0	164.0	48.0	-0.012	0.051	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	3.0	393.0	104.0	-0.052	0.066	1000.0	-1000.0	-0.032	-1000.0
Arf6 trafficking events	3.0	263.0	71.0	-0.044	0.049	1000.0	-1000.0	-0.023	-1000.0
VEGFR1 specific signals	3.0	197.0	56.0	-0.022	0.053	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	3.0	60.0	20.0	-0.008	0.034	1000.0	-1000.0	-0.014	-1000.0
Canonical NF-kappaB pathway	2.0	115.0	39.0	-0.01	0.057	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	2.0	187.0	75.0	-0.027	0.07	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	2.0	58.0	22.0	-0.005	0.052	1000.0	-1000.0	-0.039	-1000.0
Atypical NF-kappaB pathway	2.0	79.0	31.0	-0.012	0.033	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	36.0	23.0	0.006	0.045	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	1.0	67.0	54.0	-0.007	0.039	1000.0	-1000.0	-0.015	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	23.0	27.0	-0.015	0.059	1000.0	-1000.0	-0.03	-1000.0
Alternative NF-kappaB pathway	0.0	8.0	13.0	-0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	2139	129112	7203	-7.79557925579	-993.428976809	131000	-131000	-4.93060098015	-131000