Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
KIT	26 (18%)	121	0.0017	0.063	0.00012	0.0054	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573	9.9999e-06	0.000573
KRAS	19 (13%)	128	0.0063099	0.166	0.00032	0.0126	0.00308	0.102	0.00019	0.00798	9.9999e-06	0.000573	0.00181	0.0633	2e-05	0.000969	9.9999e-06	0.000573	9.9999e-06	0.000573	2e-05	0.000969
ANKLE1	12 (8%)	135	0.15352	0.828	0.28686	1	0.86881	1	0.36338	1	0.63709	1	0.87603	1	1	1	0.74016	1	0.73938	1	0.42088	1
FAM104B	7 (5%)	140	0.37679	1	0.50192	1	0.38151	1	0.61685	1	0.35256	1	0.26401	1	0.097329	0.652	0.24983	1	0.54026	1	0.5446	1
CSGALNACT2	5 (3%)	142	0.01303	0.227	0.19428	0.925	0.0087499	0.194	0.02294	0.304	0.0086499	0.194	0.01151	0.213	0.03086	0.341	0.01622	0.249	0.02467	0.305	0.077899	0.613
DDX11	8 (5%)	139	1	1	0.27936	1	0.27935	1	0.14469	0.814	0.40793	1	0.36315	1	0.13185	0.791	0.29124	1	0.6524	1	0.10114	0.67
NRAS	7 (5%)	140	0.050379	0.475	0.079789	0.621	0.097269	0.652	0.27508	1	0.01657	0.249	0.14455	0.814	0.01305	0.227	0.01792	0.258	0.069069	0.558	0.01333	0.227
PNPLA4	5 (3%)	142	0.52061	1	1	1	0.37812	1	0.61553	1	0.52153	1	0.55337	1	0.37371	1	0.44919	1	0.31844	1	0.47622	1
SERINC2	4 (3%)	143	0.46218	1	0.83423	1	0.13893	0.807	0.10322	0.67	0.81129	1	0.73836	1	1	1	0.58527	1	0.81234	1	0.84307	1
RBM10	5 (3%)	142	0.6206	1	0.27738	1	0.91997	1	0.72374	1	0.45038	1	0.70933	1	0.63361	1	0.59811	1	0.60389	1	0.55495	1
DEK	5 (3%)	142	0.03593	0.384	0.86503	1	0.62222	1	0.27518	1	0.38138	1	0.01843	0.258	0.37641	1	0.31938	1	0.4415	1	0.15728	0.84
ERC1	7 (5%)	140	0.88583	1	0.79634	1	0.60679	1	0.86513	1	1	1	0.56128	1	1	1	1	1	1	1	0.95404	1
HSF4	6 (4%)	141	0.24673	1	0.21733	0.978	0.39225	1	1	1	0.42296	1	0.14219	0.814	0.20155	0.934	0.36934	1	0.27596	1	0.28421	1
MUC6	15 (10%)	132	0.69466	1	0.62211	1	0.35071	1	0.089359	0.643	0.8338	1	0.96556	1	1	1	0.73471	1	0.77521	1	0.91749	1
FANK1	4 (3%)	143	0.38569	1	0.83452	1	0.17603	0.909	0.60103	1	0.37806	1	0.70918	1	0.45451	1	0.27842	1	0.27132	1	0.19089	0.925
MLLT3	4 (3%)	143	0.55896	1	0.83257	1	NA	NA	NA	NA	0.80963	1	0.28316	1	1	1	0.58662	1	0.46436	1	0.84165	1
RHPN2	6 (4%)	141	0.87836	1	0.24671	1	1	1	1	1	0.8803	1	0.92056	1	0.57691	1	1	1	1	1	0.85291	1
SP8	6 (4%)	141	0.089669	0.643	0.51651	1	0.03085	0.341	0.02375	0.304	0.01568	0.247	0.0067599	0.17	0.04811	0.475	0.02141	0.293	0.02412	0.304	0.083869	0.633
KRTAP1-1	3 (2%)	144	1	1	0.77437	1	NA	NA	NA	NA	0.79428	1	0.47495	1	0.77903	1	0.6144	1	0.61019	1	0.70361	1
ANKRD11	7 (5%)	140	0.88724	1	0.081679	0.628	0.77658	1	0.57126	1	0.25746	1	0.85117	1	0.33483	1	0.28571	1	0.27746	1	0.37926	1
SPIN2A	3 (2%)	144	0.63067	1	1	1	NA	NA	NA	NA	1	1	0.37337	1	1	1	1	1	1	1	0.89151	1
ATXN3	3 (2%)	144	0.77857	1	0.30046	1	0.21673	0.978	0.054709	0.5	0.15356	0.828	0.18022	0.916	0.48896	1	0.093159	0.643	0.093089	0.643	0.50166	1
MEF2A	3 (2%)	144	1	1	1	1	NA	NA	NA	NA	1	1	0.33019	1	1	1	1	1	1	1	0.89203	1
SSBP3	3 (2%)	144	0.77842	1	0.29799	1	NA	NA	NA	NA	0.15375	0.828	0.058219	0.509	0.48919	1	0.093949	0.643	0.092739	0.643	0.50266	1
KRTAP10-10	5 (3%)	142	1	1	0.6259	1	0.7313	1	0.53465	1	0.45096	1	0.86986	1	0.18547	0.925	0.59795	1	0.60193	1	0.61672	1
BCL11B	5 (3%)	142	0.5189	1	0.2766	1	0.65314	1	0.53397	1	0.32253	1	0.93587	1	0.52682	1	0.38242	1	0.44062	1	0.42301	1
FAM101B	4 (3%)	143	1	1	0.69031	1	1	1	1	1	1	1	0.50141	1	1	1	1	1	1	1	1	1
PSMD11	4 (3%)	143	0.067789	0.555	0.03676	0.386	0.44037	1	0.22934	1	0.19349	0.925	0.75315	1	0.3152	1	0.19515	0.925	0.36651	1	0.13431	0.798
FAM8A1	3 (2%)	144	0.49652	1	0.10829	0.689	NA	NA	NA	NA	0.24845	1	0.51795	1	0.059749	0.516	0.34187	1	0.33235	1	0.02414	0.304
SPTAN1	4 (3%)	143	0.03845	0.397	0.32331	1	NA	NA	NA	NA	0.00444	0.133	0.0094999	0.194	0.00486	0.136	0.0093899	0.194	0.01058	0.202	0.0146	0.236
CRB2	6 (4%)	141	0.5791	1	0.59427	1	0.77762	1	0.57383	1	0.66103	1	0.43948	1	0.44856	1	0.65949	1	0.65899	1	0.064849	0.545
OPLAH	4 (3%)	143	0.82425	1	0.54943	1	0.52841	1	1	1	1	1	0.30907	1	0.5596	1	0.27758	1	1	1	0.53942	1
C22ORF43	3 (2%)	144	0.37347	1	1	1	0.056269	0.506	1	1	1	1	0.73456	1	1	1	1	1	1	1	1	1
GAS2L2	3 (2%)	144	1	1	0.20073	0.934	0.85479	1	0.60096	1	1	1	0.42053	1	1	1	1	1	1	1	1	1
CDC27	6 (4%)	141	0.03355	0.364	0.775	1	0.18907	0.925	0.17909	0.916	0.16949	0.89	0.057409	0.509	0.32996	1	0.13776	0.807	0.16858	0.89	0.04885	0.475
MUC2	16 (11%)	131	0.40026	1	0.94477	1	0.2617	1	0.42503	1	0.51839	1	0.98455	1	0.50066	1	0.94427	1	0.79202	1	0.7928	1
TPTE2	5 (3%)	142	0.62217	1	0.2318	1	1	1	1	1	0.31806	1	0.63608	1	0.050549	0.475	0.38056	1	0.44282	1	0.42243	1
NAT10	4 (3%)	143	0.3875	1	1	1	0.85505	1	0.60178	1	1	1	0.25424	1	0.83243	1	1	1	1	1	0.49257	1
INTS4	3 (2%)	144	1	1	1	1	NA	NA	NA	NA	0.79622	1	0.95002	1	0.62906	1	0.61401	1	0.60773	1	0.70656	1
TTC38	4 (3%)	143	0.38367	1	0.11429	0.709	0.89111	1	0.19704	0.926	0.2871	1	0.81744	1	0.19306	0.925	0.38065	1	0.57791	1	0.25475	1
RBM3	3 (2%)	144	0.37359	1	0.77394	1	NA	NA	NA	NA	0.79561	1	0.94983	1	0.11477	0.709	0.618	1	0.60546	1	0.13099	0.791
TCHH	5 (3%)	142	0.51845	1	0.13123	0.791	0.073379	0.585	0.533	1	0.3788	1	0.90941	1	0.37233	1	0.32158	1	0.209	0.954	0.33103	1
ZC3H11A	3 (2%)	144	0.052649	0.488	0.77407	1	NA	NA	NA	NA	0.61755	1	0.47119	1	0.37252	1	0.7963	1	0.79385	1	0.3974	1
RAC1	4 (3%)	143	0.38388	1	0.38765	1	0.62	1	1	1	0.59046	1	0.6342	1	0.31559	1	0.48145	1	0.36634	1	0.084949	0.633
MTIF3	3 (2%)	144	1	1	0.4017	1	1	1	1	1	0.62077	1	1	1	0.37282	1	0.79701	1	0.79337	1	0.79669	1
MFF	3 (2%)	144	1	1	0.77448	1	0.61738	1	1	1	0.79656	1	0.94939	1	0.63084	1	0.61668	1	0.60804	1	0.70356	1
PABPC3	4 (3%)	143	1	1	0.46393	1	NA	NA	NA	NA	0.2844	1	0.6094	1	0.192	0.925	0.37994	1	0.57623	1	0.30545	1
CUX1	5 (3%)	142	0.73076	1	0.8634	1	0.8559	1	0.60176	1	0.72244	1	0.96152	1	0.63538	1	0.85468	1	0.85756	1	0.72012	1
PCMTD1	5 (3%)	142	0.091489	0.643	0.62528	1	0.46245	1	0.53486	1	0.38215	1	0.44743	1	0.37326	1	0.31673	1	0.20822	0.954	0.33028	1
EZH2	4 (3%)	143	0.82595	1	0.54848	1	NA	NA	NA	NA	0.37866	1	0.54439	1	0.5604	1	0.27786	1	0.27535	1	0.27862	1
HTT	3 (2%)	144	1	1	0.77447	1	NA	NA	NA	NA	0.7947	1	0.68199	1	0.62821	1	0.61825	1	0.60642	1	0.70452	1
GSX2	4 (3%)	143	0.31016	1	0.3245	1	0.32402	1	0.02734	0.315	0.69759	1	0.24263	1	0.066609	0.552	0.15059	0.828	0.81275	1	0.78782	1
AHDC1	4 (3%)	143	0.55967	1	0.0079199	0.192	0.061929	0.527	0.10827	0.689	0.00412	0.13	0.02684	0.315	0.00496	0.136	0.0095499	0.194	0.01024	0.202	0.01426	0.236
RFC3	3 (2%)	144	1	1	0.51997	1	0.52754	1	0.59923	1	0.45076	1	0.32886	1	0.77868	1	0.24356	1	1	1	0.25155	1
CHD4	4 (3%)	143	1	1	0.68965	1	1	1	0.83067	1	1	1	0.40866	1	1	1	1	1	0.57569	1	1	1
RUNX2	4 (3%)	143	1	1	0.68643	1	0.85601	1	0.6008	1	1	1	1	1	0.83168	1	1	1	1	1	0.49471	1
SP4	4 (3%)	143	0.30598	1	0.01844	0.258	NA	NA	NA	NA	0.050259	0.475	0.11153	0.703	0.25185	1	0.02736	0.315	0.0275	0.315	0.17278	0.9
DIAPH1	3 (2%)	144	1	1	0.64375	1	NA	NA	NA	NA	0.62049	1	0.81255	1	1	1	0.79434	1	0.79626	1	0.79693	1
PLEC	10 (7%)	137	0.04985	0.475	0.27183	1	0.37892	1	0.14808	0.826	0.63948	1	0.19523	0.925	0.42462	1	0.6983	1	0.33607	1	0.085409	0.633
NHS	3 (2%)	144	0.77992	1	0.77303	1	0.3182	1	1	1	0.79355	1	0.77244	1	0.62666	1	0.61758	1	0.60806	1	0.7048	1
PIK3CD	4 (3%)	143	0.24038	1	0.26493	1	NA	NA	NA	NA	0.48285	1	0.36906	1	0.1396	0.807	0.69945	1	0.68974	1	0.10212	0.67
EPAS1	5 (3%)	142	0.4465	1	0.86557	1	0.8082	1	0.82979	1	0.72357	1	0.7879	1	0.63308	1	0.8529	1	0.85781	1	0.71933	1
DLC1	3 (2%)	144	0.27631	1	1	1	0.6226	1	1	1	0.79646	1	0.95016	1	0.62872	1	0.6163	1	0.60801	1	0.7022	1