Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within FOXA2 and FOXA3 transcription factor networks 31.0 1468.0 46.0 -0.957 0.017 1000.0 -1000.0 -0.089 -1000.0 Signaling events mediated by the Hedgehog family 27.0 1411.0 52.0 -0.394 0.24 1000.0 -1000.0 -0.098 -1000.0 IL23-mediated signaling events 25.0 1513.0 60.0 -0.5 0.022 1000.0 -1000.0 -0.154 -1000.0 IL4-mediated signaling events 23.0 2100.0 91.0 -0.657 0.57 1000.0 -1000.0 -0.154 -1000.0 Syndecan-1-mediated signaling events 22.0 764.0 34.0 -0.312 0.011 1000.0 -1000.0 -0.081 -1000.0 Ephrin A reverse signaling 22.0 160.0 7.0 -0.159 0.0 1000.0 -1000.0 -0.039 -1000.0 Syndecan-4-mediated signaling events 18.0 1207.0 67.0 -0.301 0.042 1000.0 -1000.0 -0.104 -1000.0 amb2 Integrin signaling 17.0 1453.0 82.0 -0.354 0.011 1000.0 -1000.0 -0.095 -1000.0 Wnt signaling 17.0 125.0 7.0 -0.135 0.009 1000.0 -1000.0 -0.067 -1000.0 Osteopontin-mediated events 16.0 642.0 38.0 -0.231 0.011 1000.0 -1000.0 -0.113 -1000.0 Glypican 1 network 16.0 774.0 48.0 -0.332 0.025 1000.0 -1000.0 -0.061 -1000.0 Endothelins 16.0 1576.0 96.0 -0.231 0.011 1000.0 -1000.0 -0.093 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 15.0 533.0 34.0 -0.122 0.011 1000.0 -1000.0 -0.082 -1000.0 p75(NTR)-mediated signaling 15.0 1943.0 125.0 -0.439 0.011 1000.0 -1000.0 -0.105 -1000.0 Glucocorticoid receptor regulatory network 15.0 1816.0 114.0 -0.698 0.299 1000.0 -1000.0 -0.085 -1000.0 Reelin signaling pathway 15.0 892.0 56.0 -0.264 0.011 1000.0 -1000.0 -0.103 -1000.0 E-cadherin signaling events 15.0 77.0 5.0 -0.142 0.011 1000.0 -1000.0 -0.055 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 15.0 1181.0 78.0 -0.196 0.103 1000.0 -1000.0 -0.08 -1000.0 IL12-mediated signaling events 14.0 1285.0 87.0 -0.328 0.113 1000.0 -1000.0 -0.132 -1000.0 Integrins in angiogenesis 14.0 1235.0 84.0 -0.339 0.022 1000.0 -1000.0 -0.113 -1000.0 Calcium signaling in the CD4+ TCR pathway 14.0 462.0 31.0 -0.398 0.011 1000.0 -1000.0 -0.128 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 14.0 987.0 68.0 -0.418 0.053 1000.0 -1000.0 -0.146 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 14.0 1058.0 74.0 -0.16 0.087 1000.0 -1000.0 -0.119 -1000.0 BMP receptor signaling 13.0 1090.0 81.0 -0.294 0.045 1000.0 -1000.0 -0.108 -1000.0 Signaling events regulated by Ret tyrosine kinase 12.0 1060.0 82.0 -0.182 0.011 1000.0 -1000.0 -0.093 -1000.0 IL27-mediated signaling events 12.0 617.0 51.0 -0.252 0.122 1000.0 -1000.0 -0.106 -1000.0 Caspase cascade in apoptosis 11.0 885.0 74.0 -0.23 0.085 1000.0 -1000.0 -0.05 -1000.0 TCR signaling in naïve CD8+ T cells 11.0 1075.0 93.0 -0.153 0.027 1000.0 -1000.0 -0.092 -1000.0 IL6-mediated signaling events 11.0 860.0 75.0 -0.246 0.049 1000.0 -1000.0 -0.096 -1000.0 Noncanonical Wnt signaling pathway 10.0 278.0 26.0 -0.163 0.011 1000.0 -1000.0 -0.103 -1000.0 Signaling mediated by p38-alpha and p38-beta 9.0 417.0 44.0 -0.231 0.011 1000.0 -1000.0 -0.056 -1000.0 LPA receptor mediated events 9.0 995.0 102.0 -0.184 0.011 1000.0 -1000.0 -0.114 -1000.0 IGF1 pathway 9.0 533.0 57.0 -0.122 0.018 1000.0 -1000.0 -0.112 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 9.0 1160.0 120.0 -0.328 0.26 1000.0 -1000.0 -0.099 -1000.0 HIF-1-alpha transcription factor network 8.0 614.0 76.0 -0.203 0.058 1000.0 -1000.0 -0.141 -1000.0 Arf6 signaling events 8.0 508.0 62.0 -0.24 0.011 1000.0 -1000.0 -0.077 -1000.0 Nectin adhesion pathway 8.0 520.0 63.0 -0.21 0.019 1000.0 -1000.0 -0.084 -1000.0 Nongenotropic Androgen signaling 8.0 455.0 52.0 -0.126 0.021 1000.0 -1000.0 -0.067 -1000.0 E-cadherin signaling in the nascent adherens junction 8.0 672.0 76.0 -0.143 0.011 1000.0 -1000.0 -0.097 -1000.0 BCR signaling pathway 8.0 813.0 99.0 -0.153 0.03 1000.0 -1000.0 -0.106 -1000.0 Coregulation of Androgen receptor activity 7.0 602.0 76.0 -0.583 0.023 1000.0 -1000.0 -0.061 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 7.0 415.0 54.0 -0.284 0.022 1000.0 -1000.0 -0.112 -1000.0 Presenilin action in Notch and Wnt signaling 7.0 440.0 61.0 -0.261 0.018 1000.0 -1000.0 -0.087 -1000.0 Syndecan-3-mediated signaling events 7.0 262.0 35.0 -0.146 0.011 1000.0 -1000.0 -0.073 -1000.0 EGFR-dependent Endothelin signaling events 7.0 157.0 21.0 -0.096 0.011 1000.0 -1000.0 -0.075 -1000.0 Regulation of Androgen receptor activity 7.0 499.0 70.0 -0.595 0.028 1000.0 -1000.0 -0.075 -1000.0 ErbB4 signaling events 6.0 442.0 69.0 -0.391 0.087 1000.0 -1000.0 -0.094 -1000.0 BARD1 signaling events 6.0 351.0 57.0 -0.077 0.068 1000.0 -1000.0 -0.076 -1000.0 Visual signal transduction: Cones 6.0 245.0 38.0 -0.086 0.011 1000.0 -1000.0 -0.081 -1000.0 JNK signaling in the CD4+ TCR pathway 6.0 117.0 17.0 -0.089 0.011 1000.0 -1000.0 -0.077 -1000.0 IFN-gamma pathway 6.0 445.0 68.0 -0.18 0.029 1000.0 -1000.0 -0.11 -1000.0 Ephrin B reverse signaling 6.0 299.0 48.0 -0.1 0.071 1000.0 -1000.0 -0.084 -1000.0 FAS signaling pathway (CD95) 6.0 318.0 47.0 -0.144 0.02 1000.0 -1000.0 -0.059 -1000.0 Canonical Wnt signaling pathway 6.0 332.0 51.0 -0.261 0.041 1000.0 -1000.0 -0.067 -1000.0 Effects of Botulinum toxin 6.0 175.0 26.0 -0.101 0.011 1000.0 -1000.0 -0.076 -1000.0 Ras signaling in the CD4+ TCR pathway 6.0 106.0 17.0 -0.038 0.01 1000.0 -1000.0 -0.056 -1000.0 LPA4-mediated signaling events 5.0 71.0 12.0 -0.121 0.016 1000.0 -1000.0 -0.036 -1000.0 Regulation of nuclear SMAD2/3 signaling 5.0 693.0 136.0 -0.29 0.104 1000.0 -1000.0 -0.095 -1000.0 Thromboxane A2 receptor signaling 5.0 578.0 105.0 -0.092 0.035 1000.0 -1000.0 -0.084 -1000.0 Syndecan-2-mediated signaling events 5.0 404.0 69.0 -0.146 0.036 1000.0 -1000.0 -0.074 -1000.0 a4b1 and a4b7 Integrin signaling 5.0 26.0 5.0 -0.051 -0.009 1000.0 -1000.0 -0.044 -1000.0 Signaling events mediated by PTP1B 5.0 453.0 76.0 -0.163 0.04 1000.0 -1000.0 -0.088 -1000.0 PDGFR-alpha signaling pathway 5.0 220.0 44.0 -0.203 0.025 1000.0 -1000.0 -0.075 -1000.0 Retinoic acid receptors-mediated signaling 5.0 313.0 58.0 -0.086 0.025 1000.0 -1000.0 -0.071 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 5.0 229.0 45.0 -0.123 0.02 1000.0 -1000.0 -0.095 -1000.0 EPHB forward signaling 5.0 434.0 85.0 -0.159 0.059 1000.0 -1000.0 -0.116 -1000.0 TCGA08_retinoblastoma 5.0 47.0 8.0 -0.026 0.012 1000.0 -1000.0 -0.024 -1000.0 Visual signal transduction: Rods 5.0 289.0 52.0 -0.106 0.011 1000.0 -1000.0 -0.097 -1000.0 Signaling events mediated by PRL 5.0 176.0 34.0 -0.243 0.033 1000.0 -1000.0 -0.06 -1000.0 ErbB2/ErbB3 signaling events 4.0 274.0 65.0 -0.077 0.026 1000.0 -1000.0 -0.08 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 4.0 409.0 85.0 -0.139 0.011 1000.0 -1000.0 -0.096 -1000.0 EPO signaling pathway 4.0 237.0 55.0 -0.065 0.041 1000.0 -1000.0 -0.114 -1000.0 Fc-epsilon receptor I signaling in mast cells 4.0 475.0 97.0 -0.122 0.026 1000.0 -1000.0 -0.106 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 4.0 173.0 37.0 -0.118 0.012 1000.0 -1000.0 -0.096 -1000.0 IL1-mediated signaling events 4.0 299.0 62.0 -0.153 0.059 1000.0 -1000.0 -0.123 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 4.0 255.0 52.0 -0.104 0.019 1000.0 -1000.0 -0.069 -1000.0 IL2 signaling events mediated by PI3K 4.0 288.0 58.0 -0.105 0.029 1000.0 -1000.0 -0.094 -1000.0 Regulation of p38-alpha and p38-beta 4.0 240.0 54.0 -0.163 0.011 1000.0 -1000.0 -0.07 -1000.0 IL2 signaling events mediated by STAT5 4.0 109.0 22.0 -0.086 0.012 1000.0 -1000.0 -0.054 -1000.0 Regulation of Telomerase 4.0 456.0 102.0 -0.184 0.039 1000.0 -1000.0 -0.116 -1000.0 E-cadherin signaling in keratinocytes 4.0 212.0 43.0 -0.151 0.036 1000.0 -1000.0 -0.084 -1000.0 Cellular roles of Anthrax toxin 3.0 133.0 39.0 -0.056 0.015 1000.0 -1000.0 -0.034 -1000.0 Aurora A signaling 3.0 218.0 60.0 -0.353 0.035 1000.0 -1000.0 -0.068 -1000.0 Ceramide signaling pathway 3.0 293.0 76.0 -0.117 0.025 1000.0 -1000.0 -0.075 -1000.0 TRAIL signaling pathway 3.0 181.0 48.0 -0.035 0.024 1000.0 -1000.0 -0.074 -1000.0 HIF-2-alpha transcription factor network 3.0 132.0 43.0 -0.086 0.028 1000.0 -1000.0 -0.102 -1000.0 TCGA08_p53 3.0 23.0 7.0 -0.011 0.011 1000.0 -1000.0 -0.025 -1000.0 Plasma membrane estrogen receptor signaling 3.0 305.0 86.0 -0.117 0.046 1000.0 -1000.0 -0.09 -1000.0 Angiopoietin receptor Tie2-mediated signaling 3.0 328.0 88.0 -0.188 0.081 1000.0 -1000.0 -0.12 -1000.0 FOXM1 transcription factor network 3.0 200.0 51.0 -0.103 0.139 1000.0 -1000.0 -0.165 -1000.0 Sphingosine 1-phosphate (S1P) pathway 2.0 80.0 28.0 -0.077 0.019 1000.0 -1000.0 -0.065 -1000.0 PLK2 and PLK4 events 2.0 8.0 3.0 -0.012 0.011 1000.0 -1000.0 -0.022 -1000.0 Hedgehog signaling events mediated by Gli proteins 2.0 137.0 65.0 -0.262 0.05 1000.0 -1000.0 -0.067 -1000.0 Aurora C signaling 2.0 15.0 7.0 -0.026 0.005 1000.0 -1000.0 -0.048 -1000.0 Signaling events mediated by HDAC Class III 2.0 109.0 40.0 -0.091 0.025 1000.0 -1000.0 -0.049 -1000.0 ceramide signaling pathway 2.0 141.0 49.0 -0.059 0.028 1000.0 -1000.0 -0.047 -1000.0 FoxO family signaling 2.0 170.0 64.0 -0.157 0.093 1000.0 -1000.0 -0.079 -1000.0 Paxillin-dependent events mediated by a4b1 2.0 72.0 36.0 -0.051 0.022 1000.0 -1000.0 -0.092 -1000.0 Atypical NF-kappaB pathway 2.0 62.0 31.0 -0.042 0.022 1000.0 -1000.0 -0.081 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 2.0 304.0 125.0 -0.101 0.066 1000.0 -1000.0 -0.126 -1000.0 TCGA08_rtk_signaling 2.0 58.0 26.0 -0.054 0.037 1000.0 -1000.0 -0.026 -1000.0 Class I PI3K signaling events 2.0 183.0 73.0 -0.163 0.026 1000.0 -1000.0 -0.092 -1000.0 Insulin Pathway 2.0 215.0 74.0 -0.068 0.034 1000.0 -1000.0 -0.102 -1000.0 S1P3 pathway 2.0 94.0 42.0 -0.077 0.035 1000.0 -1000.0 -0.068 -1000.0 Rapid glucocorticoid signaling 2.0 59.0 20.0 -0.05 0.011 1000.0 -1000.0 -0.044 -1000.0 Class IB PI3K non-lipid kinase events 2.0 6.0 3.0 -0.0 -1000.0 1000.0 -1000.0 -0.017 -1000.0 S1P4 pathway 2.0 61.0 25.0 -0.035 0.011 1000.0 -1000.0 -0.063 -1000.0 p38 MAPK signaling pathway 2.0 113.0 44.0 -0.076 0.016 1000.0 -1000.0 -0.074 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 1.0 28.0 23.0 -0.054 0.041 1000.0 -1000.0 -0.088 -1000.0 Signaling events mediated by HDAC Class II 1.0 75.0 75.0 -0.108 0.017 1000.0 -1000.0 -0.07 -1000.0 PLK1 signaling events 1.0 93.0 85.0 -0.03 0.028 1000.0 -1000.0 -0.057 -1000.0 mTOR signaling pathway 1.0 89.0 53.0 -0.022 0.024 1000.0 -1000.0 -0.074 -1000.0 Class I PI3K signaling events mediated by Akt 1.0 88.0 68.0 -0.064 0.04 1000.0 -1000.0 -0.076 -1000.0 S1P5 pathway 1.0 21.0 17.0 -0.021 0.018 1000.0 -1000.0 -0.058 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 92.0 83.0 -0.064 0.059 1000.0 -1000.0 -0.093 -1000.0 S1P1 pathway 1.0 50.0 36.0 -0.027 0.026 1000.0 -1000.0 -0.077 -1000.0 Signaling events mediated by HDAC Class I 1.0 173.0 104.0 -0.108 0.046 1000.0 -1000.0 -0.079 -1000.0 Glypican 2 network 1.0 6.0 4.0 -0.009 0.005 1000.0 -1000.0 -0.038 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 1.0 50.0 33.0 -0.066 0.029 1000.0 -1000.0 -0.069 -1000.0 PDGFR-beta signaling pathway 1.0 103.0 97.0 -0.098 0.058 1000.0 -1000.0 -0.101 -1000.0 Aurora B signaling 1.0 108.0 67.0 -0.077 0.027 1000.0 -1000.0 -0.078 -1000.0 Canonical NF-kappaB pathway 0.0 34.0 39.0 -0.059 0.078 1000.0 -1000.0 -0.093 -1000.0 Circadian rhythm pathway 0.0 12.0 22.0 -0.014 0.043 1000.0 -1000.0 -0.085 -1000.0 Arf6 downstream pathway 0.0 10.0 43.0 -0.026 0.028 1000.0 -1000.0 -0.05 -1000.0 Insulin-mediated glucose transport 0.0 25.0 32.0 -0.064 0.04 1000.0 -1000.0 -0.071 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 13.0 15.0 -0.007 0.032 1000.0 -1000.0 -0.048 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 1.0 27.0 -0.001 0.028 1000.0 -1000.0 -0.066 -1000.0 Arf6 trafficking events 0.0 27.0 71.0 -0.037 0.037 1000.0 -1000.0 -0.09 -1000.0 VEGFR1 specific signals 0.0 53.0 56.0 -0.035 0.061 1000.0 -1000.0 -0.102 -1000.0 Arf1 pathway 0.0 6.0 54.0 -0.007 0.031 1000.0 -1000.0 -0.059 -1000.0 Alternative NF-kappaB pathway 0.0 5.0 13.0 -0.005 0.011 1000.0 -1000.0 -0.077 -1000.0 Total 865 54641 7203 -21.7006571405 -994.565967229 131000 -131000 -10.8376433443 -131000