Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.226 0.407 -9999.0 0.0 -0.906 35.0 35.0 IHH -0.123 0.304 -9999.0 0.0 -0.726 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.053 0.165 -9999.0 0.0 -0.395 28.0 28.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.164 0.392 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.141 0.237 -9999.0 0.0 -0.5 34.0 34.0 SMO -0.145 0.246 -9999.0 0.0 -0.525 34.0 34.0 AKT1 -0.051 0.138 -9999.0 0.0 -0.69 3.0 3.0 ARRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.162 -9999.0 0.0 -0.67 8.0 8.0 ADRBK1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 STIL -0.16 0.23 0.327 1.0 -0.481 31.0 32.0 DHH N/PTCH2 0.014 0.133 -9999.0 0.0 -0.563 7.0 7.0 DHH N/PTCH1 -0.129 0.248 -9999.0 0.0 -0.443 50.0 50.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.004 0.14 -9999.0 0.0 -0.67 6.0 6.0 PTHLH -0.247 0.386 -9999.0 0.0 -0.871 35.0 35.0 determination of left/right symmetry -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 PIK3R1 0.02 0.057 -9999.0 0.0 -0.67 1.0 1.0 skeletal system development -0.244 0.381 -9999.0 0.0 -0.859 35.0 35.0 IHH N/Hhip -0.162 0.325 -9999.0 0.0 -0.614 47.0 47.0 DHH N/Hhip -0.082 0.25 -9999.0 0.0 -0.522 35.0 35.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 pancreas development -0.106 0.285 -9999.0 0.0 -0.659 31.0 31.0 HHAT 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.045 -9999.0 0.0 -0.506 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.082 -9999.0 0.0 -0.67 2.0 2.0 somite specification -0.148 0.241 -9999.0 0.0 -0.516 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.169 0.239 -9999.0 0.0 -0.413 63.0 63.0 SHH Np/Cholesterol/PTCH2 -0.057 0.166 -9999.0 0.0 -0.402 28.0 28.0 SHH Np/Cholesterol/Megalin -0.122 0.244 -9999.0 0.0 -0.445 51.0 51.0 SHH -0.08 0.196 -9999.0 0.0 -0.507 26.0 26.0 catabolic process -0.14 0.243 -9999.0 0.0 -0.446 54.0 54.0 SMO/Vitamin D3 -0.165 0.261 0.473 1.0 -0.507 35.0 36.0 SHH Np/Cholesterol/Hhip -0.126 0.246 -9999.0 0.0 -0.465 47.0 47.0 LRP2 -0.099 0.294 -9999.0 0.0 -0.67 31.0 31.0 receptor-mediated endocytosis -0.224 0.282 -9999.0 0.0 -0.674 30.0 30.0 SHH Np/Cholesterol/BOC -0.063 0.192 0.191 1.0 -0.42 32.0 33.0 SHH Np/Cholesterol/CDO -0.056 0.157 -9999.0 0.0 -0.396 26.0 26.0 mesenchymal cell differentiation 0.125 0.244 0.461 47.0 -9999.0 0.0 47.0 mol:Vitamin D3 -0.161 0.252 0.434 1.0 -0.415 63.0 64.0 IHH N/PTCH2 -0.072 0.212 -9999.0 0.0 -0.478 30.0 30.0 CDON 0.016 0.031 -9999.0 0.0 -0.342 1.0 1.0 IHH N/PTCH1 -0.127 0.258 -9999.0 0.0 -0.451 54.0 54.0 Megalin/LRPAP1 -0.062 0.228 -9999.0 0.0 -0.506 31.0 31.0 PTCH2 0.016 0.08 -9999.0 0.0 -0.67 2.0 2.0 SHH Np/Cholesterol -0.059 0.157 -9999.0 0.0 -0.401 26.0 26.0 PTCH1 -0.141 0.243 -9999.0 0.0 -0.447 54.0 54.0 HHIP -0.106 0.285 -9999.0 0.0 -0.66 31.0 31.0