Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.107 0.257 -9999.0 0.0 -0.68 36.0 36.0 IHH -0.2 0.365 -9999.0 0.0 -0.837 123.0 123.0 SHH Np/Cholesterol/GAS1 -0.104 0.203 -9999.0 0.0 -0.512 98.0 98.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.103 0.202 0.508 98.0 -9999.0 0.0 98.0 SMO/beta Arrestin2 -0.094 0.24 -9999.0 0.0 -0.678 16.0 16.0 SMO -0.105 0.252 -9999.0 0.0 -0.511 126.0 126.0 AKT1 -0.026 0.123 -9999.0 0.0 -0.662 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.104 -9999.0 0.0 -0.816 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.103 0.248 -9999.0 0.0 -0.503 126.0 126.0 STIL -0.076 0.197 -9999.0 0.0 -0.604 17.0 17.0 DHH N/PTCH2 -0.106 0.239 -9999.0 0.0 -0.638 83.0 83.0 DHH N/PTCH1 -0.098 0.224 -9999.0 0.0 -0.449 130.0 130.0 PIK3CA 0.008 0.064 -9999.0 0.0 -0.816 3.0 3.0 DHH 0.007 0.074 -9999.0 0.0 -0.816 4.0 4.0 PTHLH -0.155 0.366 -9999.0 0.0 -1.161 36.0 36.0 determination of left/right symmetry -0.103 0.248 -9999.0 0.0 -0.503 126.0 126.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.152 0.359 -9999.0 0.0 -1.136 36.0 36.0 IHH N/Hhip -0.381 0.396 -9999.0 0.0 -0.731 265.0 265.0 DHH N/Hhip -0.249 0.309 -9999.0 0.0 -0.631 197.0 197.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.103 0.248 -9999.0 0.0 -0.503 126.0 126.0 pancreas development -0.313 0.401 -9999.0 0.0 -0.81 197.0 197.0 HHAT 0.012 0.037 -9999.0 0.0 -0.816 1.0 1.0 PI3K -0.004 0.048 -9999.0 0.0 -0.626 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.147 0.328 -9999.0 0.0 -0.816 97.0 97.0 somite specification -0.103 0.248 -9999.0 0.0 -0.503 126.0 126.0 SHH Np/Cholesterol/PTCH1 -0.086 0.202 -9999.0 0.0 -0.616 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.087 0.188 -9999.0 0.0 -0.509 82.0 82.0 SHH Np/Cholesterol/Megalin -0.141 0.227 -9999.0 0.0 -0.513 135.0 135.0 SHH 0.007 0.049 -9999.0 0.0 -0.626 1.0 1.0 catabolic process -0.112 0.247 -9999.0 0.0 -0.506 126.0 126.0 SMO/Vitamin D3 -0.09 0.221 -9999.0 0.0 -0.653 17.0 17.0 SHH Np/Cholesterol/Hhip -0.203 0.244 -9999.0 0.0 -0.505 197.0 197.0 LRP2 -0.209 0.367 -9999.0 0.0 -0.816 134.0 134.0 receptor-mediated endocytosis -0.197 0.233 -9999.0 0.0 -0.715 49.0 49.0 SHH Np/Cholesterol/BOC -0.014 0.073 -9999.0 0.0 -0.52 9.0 9.0 SHH Np/Cholesterol/CDO -0.155 0.232 -9999.0 0.0 -0.51 149.0 149.0 mesenchymal cell differentiation 0.201 0.242 0.501 197.0 -9999.0 0.0 197.0 mol:Vitamin D3 -0.085 0.205 -9999.0 0.0 -0.623 17.0 17.0 IHH N/PTCH2 -0.228 0.343 -9999.0 0.0 -0.66 182.0 182.0 CDON -0.232 0.379 -9999.0 0.0 -0.816 148.0 148.0 IHH N/PTCH1 -0.114 0.25 -9999.0 0.0 -0.513 126.0 126.0 Megalin/LRPAP1 -0.167 0.277 -9999.0 0.0 -0.626 134.0 134.0 PTCH2 -0.121 0.305 -9999.0 0.0 -0.816 81.0 81.0 SHH Np/Cholesterol -0.006 0.035 -9999.0 0.0 -0.507 1.0 1.0 PTCH1 -0.112 0.248 -9999.0 0.0 -0.508 126.0 126.0 HHIP -0.314 0.402 -9999.0 0.0 -0.811 197.0 197.0