Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.088 0.209 -9999.0 0.0 -0.616 31.0 31.0 IHH -0.152 0.313 -9999.0 0.0 -0.701 121.0 121.0 SHH Np/Cholesterol/GAS1 -0.053 0.158 -9999.0 0.0 -0.395 84.0 84.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.157 0.392 84.0 -9999.0 0.0 84.0 SMO/beta Arrestin2 -0.074 0.205 -9999.0 0.0 -0.416 111.0 111.0 SMO -0.095 0.207 -9999.0 0.0 -0.436 119.0 119.0 AKT1 -0.016 0.105 -9999.0 0.0 -0.609 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.088 -9999.0 0.0 -0.674 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.094 0.204 -9999.0 0.0 -0.427 123.0 123.0 STIL -0.065 0.159 0.267 1.0 -0.488 14.0 15.0 DHH N/PTCH2 -0.051 0.205 -9999.0 0.0 -0.51 81.0 81.0 DHH N/PTCH1 -0.076 0.188 -9999.0 0.0 -0.365 139.0 139.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.674 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.674 4.0 4.0 PTHLH -0.137 0.31 -9999.0 0.0 -1.033 33.0 33.0 determination of left/right symmetry -0.094 0.204 -9999.0 0.0 -0.427 123.0 123.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.135 0.305 -9999.0 0.0 -1.015 33.0 33.0 IHH N/Hhip -0.292 0.332 -9999.0 0.0 -0.591 260.0 260.0 DHH N/Hhip -0.172 0.266 -9999.0 0.0 -0.507 191.0 191.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.094 0.204 -9999.0 0.0 -0.427 123.0 123.0 pancreas development -0.249 0.332 -9999.0 0.0 -0.671 190.0 190.0 HHAT 0.024 0.032 -9999.0 0.0 -0.674 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.508 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.1 0.262 -9999.0 0.0 -0.631 95.0 95.0 somite specification -0.094 0.204 -9999.0 0.0 -0.427 123.0 123.0 SHH Np/Cholesterol/PTCH1 -0.07 0.159 -9999.0 0.0 -0.336 111.0 111.0 SHH Np/Cholesterol/PTCH2 -0.043 0.15 -9999.0 0.0 -0.378 80.0 80.0 SHH Np/Cholesterol/Megalin -0.081 0.179 -9999.0 0.0 -0.381 127.0 127.0 SHH -0.005 0.029 -9999.0 0.0 -0.508 1.0 1.0 catabolic process -0.093 0.202 -9999.0 0.0 -0.404 142.0 142.0 SMO/Vitamin D3 -0.075 0.183 -9999.0 0.0 -0.383 109.0 109.0 SHH Np/Cholesterol/Hhip -0.139 0.201 -9999.0 0.0 -0.391 190.0 190.0 LRP2 -0.155 0.305 -9999.0 0.0 -0.662 132.0 132.0 receptor-mediated endocytosis -0.139 0.21 -9999.0 0.0 -0.576 47.0 47.0 SHH Np/Cholesterol/BOC 0.014 0.056 -9999.0 0.0 -0.391 8.0 8.0 SHH Np/Cholesterol/CDO -0.095 0.185 -9999.0 0.0 -0.38 143.0 143.0 mesenchymal cell differentiation 0.138 0.2 0.388 190.0 -9999.0 0.0 190.0 mol:Vitamin D3 -0.064 0.167 -9999.0 0.0 -0.34 111.0 111.0 IHH N/PTCH2 -0.169 0.288 -9999.0 0.0 -0.535 178.0 178.0 CDON -0.179 0.319 -9999.0 0.0 -0.672 147.0 147.0 IHH N/PTCH1 -0.091 0.207 -9999.0 0.0 -0.409 142.0 142.0 Megalin/LRPAP1 -0.103 0.238 -9999.0 0.0 -0.497 132.0 132.0 PTCH2 -0.085 0.256 -9999.0 0.0 -0.67 80.0 80.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -0.403 1.0 1.0 PTCH1 -0.094 0.203 -9999.0 0.0 -0.405 142.0 142.0 HHIP -0.25 0.332 -9999.0 0.0 -0.672 190.0 190.0