Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.187 0.283 -9999.0 0.0 -0.549 43.0 43.0 IHH -0.023 0.086 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.017 0.042 -9999.0 0.0 -0.286 2.0 2.0 LRPAP1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.017 0.042 0.284 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.082 0.174 -9999.0 0.0 -0.409 5.0 5.0 SMO -0.094 0.174 -9999.0 0.0 -0.427 5.0 5.0 AKT1 -0.022 0.105 -9999.0 0.0 -0.489 2.0 2.0 ARRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.096 -9999.0 0.0 -0.5 4.0 4.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.172 -9999.0 0.0 -0.421 5.0 5.0 STIL -0.067 0.146 0.305 1.0 -0.34 2.0 3.0 DHH N/PTCH2 0.02 0.097 -9999.0 0.0 -0.363 7.0 7.0 DHH N/PTCH1 -0.089 0.186 -9999.0 0.0 -0.307 46.0 46.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 DHH 0.013 0.096 -9999.0 0.0 -0.5 4.0 4.0 PTHLH -0.344 0.473 -9999.0 0.0 -0.919 47.0 47.0 determination of left/right symmetry -0.093 0.172 -9999.0 0.0 -0.421 5.0 5.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 skeletal system development -0.34 0.467 -9999.0 0.0 -0.907 47.0 47.0 IHH N/Hhip -0.071 0.165 -9999.0 0.0 -0.408 21.0 21.0 DHH N/Hhip -0.04 0.171 -9999.0 0.0 -0.375 24.0 24.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.172 -9999.0 0.0 -0.421 5.0 5.0 pancreas development -0.062 0.203 -9999.0 0.0 -0.499 21.0 21.0 HHAT 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.075 -9999.0 0.0 -0.509 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.084 -9999.0 0.0 -0.5 3.0 3.0 somite specification -0.093 0.172 -9999.0 0.0 -0.421 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.077 0.139 -9999.0 0.0 -0.253 42.0 42.0 SHH Np/Cholesterol/PTCH2 0.015 0.05 -9999.0 0.0 -0.286 3.0 3.0 SHH Np/Cholesterol/Megalin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.012 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.1 0.184 -9999.0 0.0 -0.324 46.0 46.0 SMO/Vitamin D3 -0.079 0.163 -9999.0 0.0 -0.318 5.0 5.0 SHH Np/Cholesterol/Hhip -0.016 0.1 -9999.0 0.0 -0.284 14.0 14.0 LRP2 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.081 0.157 -9999.0 0.0 -0.325 4.0 4.0 SHH Np/Cholesterol/BOC 0.012 0.057 -9999.0 0.0 -0.286 4.0 4.0 SHH Np/Cholesterol/CDO 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.017 0.1 0.282 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.057 0.169 0.377 4.0 -0.254 42.0 46.0 IHH N/PTCH2 -0.006 0.086 -9999.0 0.0 -0.4 3.0 3.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.096 0.188 -9999.0 0.0 -0.326 46.0 46.0 Megalin/LRPAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.018 0.084 -9999.0 0.0 -0.5 3.0 3.0 SHH Np/Cholesterol 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.1 0.185 -9999.0 0.0 -0.325 46.0 46.0 HHIP -0.062 0.203 -9999.0 0.0 -0.5 21.0 21.0