Correlation between gene mutation status and selected clinical features
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
02 April 2015  |  analyses__2015_04_02
Maintainer Information
Citation Information
doi:10.7908/C1QN65W4
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2015): Correlation between gene mutation status and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1QN65W4
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and selected clinical features.

Summary

Testing the association between mutation status of 197 genes and 7 clinical features across 248 patients, 12 significant findings detected with Q value < 0.25.

  • PTEN mutation correlated to 'HISTOLOGICAL_TYPE' and 'RACE'.

  • PIK3R1 mutation correlated to 'HISTOLOGICAL_TYPE'.

  • TP53 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • CTCF mutation correlated to 'HISTOLOGICAL_TYPE'.

  • KRAS mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • ARID1A mutation correlated to 'HISTOLOGICAL_TYPE'.

  • CTNNB1 mutation correlated to 'YEARS_TO_BIRTH' and 'HISTOLOGICAL_TYPE'.

  • PPP2R1A mutation correlated to 'HISTOLOGICAL_TYPE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between mutation status of 197 genes and 7 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 12 significant findings detected.

Clinical
Features 		Time
to
Death 		YEARS
TO
BIRTH 		HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		COMPLETENESS
OF
RESECTION 		RACE ETHNICITY
nMutated (%) nWild-Type logrank test Wilcoxon-test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test
PTEN 161 (65%) 87 0.0155
(0.485) 		0.00753
(0.447) 		1e-05
(0.00276) 		0.0359
(0.653) 		0.0465
(0.713) 		0.00063
(0.0724) 		1
(1.00)
TP53 69 (28%) 179 0.0187
(0.528) 		5.85e-06
(0.00276) 		1e-05
(0.00276) 		0.237
(0.768) 		0.0851
(0.756) 		0.00753
(0.447) 		1
(1.00)
KRAS 53 (21%) 195 0.0846
(0.756) 		0.000544
(0.0682) 		0.00022
(0.0379) 		0.257
(0.772) 		0.458
(0.834) 		0.498
(0.854) 		0.583
(0.897)
CTNNB1 74 (30%) 174 0.757
(0.993) 		0.000515
(0.0682) 		1e-05
(0.00276) 		0.31
(0.787) 		0.493
(0.854) 		0.728
(0.988) 		1
(1.00)
PIK3R1 83 (33%) 165 0.903
(1.00) 		0.398
(0.826) 		1e-05
(0.00276) 		0.324
(0.802) 		0.954
(1.00) 		0.108
(0.756) 		0.136
(0.756)
CTCF 44 (18%) 204 0.206
(0.756) 		0.0368
(0.659) 		0.00017
(0.0335) 		1
(1.00) 		0.735
(0.993) 		0.777
(1.00) 		1
(1.00)
ARID1A 83 (33%) 165 0.00846
(0.447) 		0.00633
(0.447) 		9e-05
(0.0207) 		0.573
(0.896) 		0.265
(0.775) 		0.247
(0.772) 		1
(1.00)
PPP2R1A 27 (11%) 221 0.92
(1.00) 		0.007
(0.447) 		0.00042
(0.0644) 		0.523
(0.874) 		1
(1.00) 		0.402
(0.826) 		0.31
(0.787)
FBXW7 39 (16%) 209 0.67
(0.956) 		0.888
(1.00) 		0.00343
(0.278) 		0.856
(1.00) 		0.528
(0.878) 		0.786
(1.00) 		0.528
(0.878)
ARHGAP35 36 (15%) 212 0.671
(0.956) 		0.914
(1.00) 		0.726
(0.988) 		1
(1.00) 		0.928
(1.00) 		0.195
(0.756) 		0.457
(0.834)
PIK3CA 132 (53%) 116 0.0226
(0.566) 		0.185
(0.756) 		0.252
(0.772) 		0.689
(0.966) 		0.187
(0.756) 		0.72
(0.985) 		1
(1.00)
FGFR2 31 (12%) 217 0.569
(0.895) 		0.983
(1.00) 		0.774
(1.00) 		1
(1.00) 		0.38
(0.824) 		0.631
(0.929) 		1
(1.00)
ZFHX3 44 (18%) 204 0.52
(0.871) 		0.744
(0.993) 		0.0666
(0.756) 		0.862
(1.00) 		0.495
(0.854) 		0.1
(0.756) 		0.126
(0.756)
TCP11L2 14 (6%) 234 0.164
(0.756) 		0.988
(1.00) 		0.171
(0.756) 		1
(1.00) 		0.247
(0.772) 		0.0902
(0.756) 		0.235
(0.766)
SPOP 21 (8%) 227 0.433
(0.826) 		0.451
(0.834) 		0.842
(1.00) 		0.812
(1.00) 		0.554
(0.882) 		0.728
(0.988) 		0.31
(0.787)
RBMX 13 (5%) 235 0.594
(0.904) 		0.233
(0.766) 		0.3
(0.779) 		0.146
(0.756) 		0.134
(0.756) 		0.213
(0.756) 		1
(1.00)
SOX17 7 (3%) 241 0.453
(0.834) 		0.452
(0.834) 		0.428
(0.826) 		0.427
(0.826) 		0.686
(0.963) 		0.0642
(0.756) 		1
(1.00)
NFE2L2 15 (6%) 233 0.687
(0.964) 		0.154
(0.756) 		0.14
(0.756) 		0.587
(0.897) 		0.779
(1.00) 		0.514
(0.869) 		1
(1.00)
CCND1 14 (6%) 234 0.625
(0.926) 		0.0652
(0.756) 		0.171
(0.756) 		0.567
(0.895) 		0.304
(0.781) 		0.757
(0.993) 		0.235
(0.766)
GNPTAB 20 (8%) 228 0.149
(0.756) 		0.324
(0.802) 		0.268
(0.775) 		0.464
(0.839) 		0.648
(0.936) 		0.501
(0.854) 		0.273
(0.775)
ARID5B 29 (12%) 219 0.801
(1.00) 		0.884
(1.00) 		0.011
(0.46) 		1
(1.00) 		0.111
(0.756) 		0.00268
(0.264) 		0.411
(0.826)
DNER 18 (7%) 230 0.539
(0.882) 		0.0325
(0.633) 		0.416
(0.826) 		0.442
(0.829) 		0.645
(0.936) 		0.102
(0.756) 		0.235
(0.766)
EP300 21 (8%) 227 0.133
(0.756) 		0.0984
(0.756) 		0.0663
(0.756) 		0.637
(0.929) 		1
(1.00) 		0.551
(0.882) 		0.0442
(0.687)
MAX 11 (4%) 237 0.904
(1.00) 		0.296
(0.775) 		0.349
(0.802) 		0.752
(0.993) 		0.405
(0.826) 		0.109
(0.756) 		1
(1.00)
SGK1 15 (6%) 233 0.916
(1.00) 		0.529
(0.879) 		0.47
(0.842) 		0.16
(0.756) 		0.1
(0.756) 		0.364
(0.806) 		1
(1.00)
NRAS 9 (4%) 239 0.209
(0.756) 		0.785
(1.00) 		1
(1.00) 		0.723
(0.986) 		1
(1.00) 		0.0423
(0.687) 		0.155
(0.756)
KLHL8 12 (5%) 236 0.269
(0.775) 		0.289
(0.775) 		0.29
(0.775) 		1
(1.00) 		0.227
(0.766) 		0.466
(0.84) 		0.176
(0.756)
MORC4 20 (8%) 228 0.103
(0.756) 		0.0146
(0.481) 		0.268
(0.775) 		1
(1.00) 		1
(1.00) 		0.736
(0.993) 		0.273
(0.775)
ZNF781 10 (4%) 238 0.344
(0.802) 		0.112
(0.756) 		0.337
(0.802) 		0.501
(0.854) 		0.491
(0.854) 		0.708
(0.98) 		0.134
(0.756)
MKI67 29 (12%) 219 0.198
(0.756) 		0.499
(0.854) 		0.0109
(0.46) 		0.836
(1.00) 		0.294
(0.775) 		0.188
(0.756) 		0.395
(0.826)
ING1 13 (5%) 235 0.308
(0.787) 		0.9
(1.00) 		0.3
(0.779) 		0.146
(0.756) 		0.843
(1.00) 		0.908
(1.00) 		1
(1.00)
INTS7 8 (3%) 240 0.272
(0.775) 		0.536
(0.882) 		0.436
(0.826) 		1
(1.00) 		0.548
(0.882) 		0.178
(0.756) 		0.113
(0.756)
CCDC6 6 (2%) 242 0.559
(0.889) 		0.749
(0.993) 		0.363
(0.806) 		1
(1.00) 		1
(1.00) 		0.534
(0.882) 		1
(1.00)
EIF2S2 9 (4%) 239 0.334
(0.802) 		0.384
(0.826) 		0.458
(0.834) 		0.169
(0.756) 		0.427
(0.826) 		0.226
(0.766) 		0.155
(0.756)
RBBP6 22 (9%) 226 0.418
(0.826) 		0.988
(1.00) 		0.0427
(0.687) 		1
(1.00) 		0.514
(0.869) 		0.282
(0.775) 		1
(1.00)
SOS1 12 (5%) 236 0.252
(0.772) 		0.108
(0.756) 		0.291
(0.775) 		0.757
(0.993) 		0.843
(1.00) 		0.894
(1.00) 		1
(1.00)
NAT1 7 (3%) 241 0.686
(0.963) 		0.983
(1.00) 		0.426
(0.826) 		1
(1.00) 		0.486
(0.854) 		0.199
(0.756) 		1
(1.00)
ADNP 14 (6%) 234 0.837
(1.00) 		0.794
(1.00) 		0.172
(0.756) 		1
(1.00) 		0.648
(0.936) 		0.908
(1.00) 		0.155
(0.756)
VPS11 12 (5%) 236 0.843
(1.00) 		0.915
(1.00) 		1
(1.00) 		0.551
(0.882) 		0.845
(1.00) 		0.362
(0.805) 		1
(1.00)
L1TD1 16 (6%) 232 0.201
(0.756) 		0.348
(0.802) 		0.119
(0.756) 		0.588
(0.897) 		0.886
(1.00) 		0.336
(0.802) 		0.235
(0.766)
MARK3 11 (4%) 237 0.85
(1.00) 		0.0516
(0.736) 		0.353
(0.802) 		1
(1.00) 		0.214
(0.756) 		0.325
(0.802) 		0.134
(0.756)
CTNND1 19 (8%) 229 0.797
(1.00) 		0.411
(0.826) 		0.427
(0.826) 		0.465
(0.839) 		0.426
(0.826) 		0.497
(0.854) 		1
(1.00)
GFAP 9 (4%) 239 0.426
(0.826) 		0.0727
(0.756) 		0.456
(0.834) 		1
(1.00) 		0.28
(0.775) 		0.351
(0.802) 		0.113
(0.756)
C9ORF102 16 (6%) 232 0.167
(0.756) 		0.318
(0.799) 		0.12
(0.756) 		0.588
(0.897) 		0.68
(0.963) 		0.334
(0.802) 		0.235
(0.766)
EIF4A2 7 (3%) 241 0.378
(0.824) 		0.205
(0.756) 		0.426
(0.826) 		0.427
(0.826) 		1
(1.00) 		0.177
(0.756) 		1
(1.00)
ZNF471 15 (6%) 233 0.746
(0.993) 		0.0355
(0.653) 		0.141
(0.756) 		0.587
(0.897) 		0.38
(0.824) 		0.0615
(0.756) 		0.235
(0.766)
CDK17 14 (6%) 234 0.58
(0.897) 		0.0852
(0.756) 		0.128
(0.756) 		0.776
(1.00) 		0.287
(0.775) 		0.359
(0.805) 		0.216
(0.756)
SIN3A 21 (8%) 227 0.366
(0.807) 		0.159
(0.756) 		0.278
(0.775) 		0.812
(1.00) 		0.9
(1.00) 		0.0975
(0.756) 		1
(1.00)
ZNF485 9 (4%) 239 0.785
(1.00) 		0.361
(0.805) 		0.457
(0.834) 		0.169
(0.756) 		0.0903
(0.756) 		0.227
(0.766) 		0.176
(0.756)
RSBN1L 12 (5%) 236 0.181
(0.756) 		0.291
(0.775) 		0.752
(0.993) 		1
(1.00) 		0.195
(0.756) 		0.00331
(0.278) 		0.196
(0.756)
CUX1 23 (9%) 225 0.406
(0.826) 		0.11
(0.756) 		0.172
(0.756) 		0.365
(0.806) 		0.829
(1.00) 		0.609
(0.911) 		1
(1.00)
BCOR 30 (12%) 218 0.0583
(0.756) 		0.0735
(0.756) 		0.00843
(0.447) 		1
(1.00) 		0.379
(0.824) 		0.0295
(0.623) 		1
(1.00)
WDR45 11 (4%) 237 0.937
(1.00) 		0.551
(0.882) 		0.351
(0.802) 		0.521
(0.871) 		0.546
(0.882) 		0.0421
(0.687) 		1
(1.00)
CAB39L 8 (3%) 240 0.294
(0.775) 		0.789
(1.00) 		0.437
(0.826) 		0.268
(0.775) 		0.55
(0.882) 		0.00918
(0.452) 		1
(1.00)
TAB3 18 (7%) 230 0.128
(0.756) 		0.0402
(0.687) 		0.0862
(0.756) 		0.614
(0.914) 		0.296
(0.775) 		0.0309
(0.623) 		0.31
(0.787)
OAZ3 8 (3%) 240 0.319
(0.799) 		0.165
(0.756) 		1
(1.00) 		0.454
(0.834) 		0.547
(0.882) 		0.109
(0.756) 		0.113
(0.756)
AHCYL1 6 (2%) 242 0.426
(0.826) 		0.0311
(0.623) 		0.632
(0.929) 		1
(1.00) 		0.416
(0.826) 		0.171
(0.756) 		0.0689
(0.756)
ATM 29 (12%) 219 0.0425
(0.687) 		0.265
(0.775) 		0.0753
(0.756) 		0.534
(0.882) 		0.904
(1.00) 		0.222
(0.761) 		0.378
(0.824)
MSH4 15 (6%) 233 0.186
(0.756) 		0.155
(0.756) 		0.141
(0.756) 		1
(1.00) 		0.649
(0.936) 		0.0705
(0.756) 		0.216
(0.756)
FAM65B 16 (6%) 232 0.175
(0.756) 		0.049
(0.725) 		0.479
(0.853) 		0.792
(1.00) 		0.778
(1.00) 		0.251
(0.772) 		0.216
(0.756)
FN1 24 (10%) 224 0.383
(0.826) 		0.714
(0.983) 		0.0216
(0.551) 		1
(1.00) 		0.568
(0.895) 		0.777
(1.00) 		0.345
(0.802)
JAKMIP2 12 (5%) 236 0.724
(0.986) 		0.0301
(0.623) 		0.289
(0.775) 		1
(1.00) 		0.275
(0.775) 		0.0294
(0.623) 		0.155
(0.756)
WBP4 8 (3%) 240 0.462
(0.839) 		0.133
(0.756) 		0.436
(0.826) 		0.718
(0.983) 		1
(1.00) 		1
(1.00) 		1
(1.00)
RASA1 22 (9%) 226 0.0855
(0.756) 		0.745
(0.993) 		0.575
(0.896) 		0.493
(0.854) 		1
(1.00) 		0.0929
(0.756) 		0.0442
(0.687)
ALPK2 19 (8%) 229 0.0894
(0.756) 		0.233
(0.766) 		0.43
(0.826) 		0.315
(0.796) 		0.255
(0.772) 		0.127
(0.756) 		0.255
(0.772)
POLE 27 (11%) 221 0.611
(0.911) 		0.552
(0.882) 		0.127
(0.756) 		0.199
(0.756) 		0.457
(0.834) 		0.37
(0.812) 		0.362
(0.805)
KIF20B 21 (8%) 227 0.143
(0.756) 		0.142
(0.756) 		0.0645
(0.756) 		0.637
(0.929) 		0.913
(1.00) 		0.552
(0.882) 		0.255
(0.772)
C14ORF166B 10 (4%) 238 0.285
(0.775) 		0.903
(1.00) 		0.335
(0.802) 		0.172
(0.756) 		1
(1.00) 		0.12
(0.756) 		1
(1.00)
SLC26A8 12 (5%) 236 0.298
(0.778) 		0.0329
(0.633) 		0.287
(0.775) 		0.551
(0.882) 		0.7
(0.975) 		0.406
(0.826) 		0.196
(0.756)
ZNF334 17 (7%) 231 0.819
(1.00) 		0.00468
(0.358) 		0.809
(1.00) 		1
(1.00) 		0.68
(0.963) 		0.734
(0.992) 		0.255
(0.772)
RRAS2 4 (2%) 244 0.637
(0.929) 		0.0213
(0.551) 		1
(1.00) 		0.611
(0.911) 		0.437
(0.826) 		1
(1.00) 		1
(1.00)
PPM1N 7 (3%) 241 0.346
(0.802) 		0.981
(1.00) 		0.426
(0.826) 		1
(1.00) 		0.426
(0.826) 		0.428
(0.826) 		0.113
(0.756)
FCN1 8 (3%) 240 0.824
(1.00) 		0.627
(0.928) 		0.438
(0.826) 		0.718
(0.983) 		1
(1.00) 		0.168
(0.756) 		1
(1.00)
TIAL1 10 (4%) 238 0.322
(0.802) 		0.272
(0.775) 		0.337
(0.802) 		1
(1.00) 		0.604
(0.908) 		0.156
(0.756) 		1
(1.00)
PSMC4 11 (4%) 237 0.252
(0.772) 		0.831
(1.00) 		0.352
(0.802) 		0.521
(0.871) 		0.857
(1.00) 		0.15
(0.756) 		1
(1.00)
MFAP5 9 (4%) 239 0.358
(0.805) 		0.0104
(0.46) 		1
(1.00) 		1
(1.00) 		0.547
(0.882) 		0.569
(0.895) 		0.134
(0.756)
RAB3GAP1 16 (6%) 232 0.771
(1.00) 		0.466
(0.84) 		0.12
(0.756) 		1
(1.00) 		0.193
(0.756) 		0.186
(0.756) 		0.011
(0.46)
MSH6 17 (7%) 231 0.533
(0.882) 		0.124
(0.756) 		0.492
(0.854) 		0.296
(0.775) 		0.679
(0.963) 		0.576
(0.896) 		0.216
(0.756)
BMP2K 13 (5%) 235 0.318
(0.799) 		0.904
(1.00) 		0.302
(0.779) 		0.551
(0.882) 		0.703
(0.976) 		0.732
(0.991) 		0.196
(0.756)
ZNF606 16 (6%) 232 0.196
(0.756) 		0.446
(0.834) 		0.12
(0.756) 		0.588
(0.897) 		0.515
(0.869) 		0.13
(0.756) 		0.0211
(0.551)
ZNF263 7 (3%) 241 0.364
(0.806) 		0.0566
(0.756) 		0.426
(0.826) 		1
(1.00) 		0.209
(0.756) 		0.355
(0.802) 		0.0689
(0.756)
CHEK2 13 (5%) 235 0.709
(0.98) 		0.0191
(0.528) 		0.575
(0.896) 		1
(1.00) 		0.207
(0.756) 		0.479
(0.853) 		0.176
(0.756)
MGA 26 (10%) 222 0.708
(0.98) 		0.67
(0.956) 		0.35
(0.802) 		0.392
(0.826) 		0.154
(0.756) 		0.355
(0.802) 		0.292
(0.775)
RHBDD3 4 (2%) 244 0.546
(0.882) 		0.128
(0.756) 		1
(1.00) 		0.611
(0.911) 		1
(1.00) 		1
(1.00) 		1
(1.00)
TAP1 8 (3%) 240 0.86
(1.00) 		0.942
(1.00) 		0.438
(0.826) 		1
(1.00) 		1
(1.00) 		0.404
(0.826) 		1
(1.00)
RB1 20 (8%) 228 0.333
(0.802) 		0.124
(0.756) 		0.0685
(0.756) 		0.464
(0.839) 		0.93
(1.00) 		0.0784
(0.756) 		1
(1.00)
SLC1A3 12 (5%) 236 0.768
(1.00) 		0.755
(0.993) 		1
(1.00) 		1
(1.00) 		0.656
(0.943) 		0.00814
(0.447) 		1
(1.00)
ATAD5 17 (7%) 231 0.154
(0.756) 		0.252
(0.772) 		0.49
(0.854) 		1
(1.00) 		0.793
(1.00) 		0.101
(0.756) 		1
(1.00)
ALG8 10 (4%) 238 0.292
(0.775) 		0.854
(1.00) 		0.336
(0.802) 		0.501
(0.854) 		0.549
(0.882) 		0.327
(0.802) 		0.0141
(0.481)
TIGD4 13 (5%) 235 0.218
(0.756) 		0.0517
(0.736) 		0.305
(0.781) 		0.771
(1.00) 		0.682
(0.963) 		0.48
(0.853) 		0.216
(0.756)
PARG 9 (4%) 239 0.312
(0.789) 		0.554
(0.882) 		0.459
(0.834) 		1
(1.00) 		1
(1.00) 		0.712
(0.981) 		1
(1.00)
FAT1 40 (16%) 208 0.0305
(0.623) 		0.875
(1.00) 		0.0443
(0.687) 		0.279
(0.775) 		0.802
(1.00) 		0.408
(0.826) 		0.118
(0.756)
DYM 10 (4%) 238 0.37
(0.812) 		0.732
(0.991) 		0.74
(0.993) 		0.742
(0.993) 		1
(1.00) 		0.586
(0.897) 		1
(1.00)
PSMD3 11 (4%) 237 0.253
(0.772) 		0.373
(0.816) 		0.746
(0.993) 		1
(1.00) 		1
(1.00) 		0.402
(0.826) 		1
(1.00)
PPM1D 11 (4%) 237 0.234
(0.766) 		0.351
(0.802) 		0.351
(0.802) 		0.339
(0.802) 		0.605
(0.908) 		0.254
(0.772) 		0.155
(0.756)
ZMYM2 17 (7%) 231 0.171
(0.756) 		0.0287
(0.623) 		0.102
(0.756) 		1
(1.00) 		0.56
(0.889) 		0.278
(0.775) 		1
(1.00)
INPP4B 12 (5%) 236 0.586
(0.897) 		0.178
(0.756) 		0.29
(0.775) 		0.0621
(0.756) 		0.207
(0.756) 		0.145
(0.756) 		0.196
(0.756)
USP28 10 (4%) 238 0.228
(0.766) 		0.502
(0.854) 		0.334
(0.802) 		0.501
(0.854) 		0.79
(1.00) 		0.352
(0.802) 		1
(1.00)
EMR1 13 (5%) 235 0.235
(0.766) 		0.127
(0.756) 		0.301
(0.779) 		0.551
(0.882) 		0.701
(0.975) 		0.389
(0.826) 		0.176
(0.756)
ZNF385B 7 (3%) 241 0.419
(0.826) 		0.204
(0.756) 		0.428
(0.826) 		1
(1.00) 		1
(1.00) 		0.501
(0.854) 		1
(1.00)
RAE1 11 (4%) 237 0.221
(0.761) 		0.729
(0.989) 		0.745
(0.993) 		0.339
(0.802) 		1
(1.00) 		0.321
(0.802) 		1
(1.00)
TRIM59 9 (4%) 239 0.283
(0.775) 		0.876
(1.00) 		0.454
(0.834) 		1
(1.00) 		1
(1.00) 		0.0396
(0.687) 		1
(1.00)
ZNF721 13 (5%) 235 0.263
(0.775) 		0.0494
(0.725) 		0.302
(0.779) 		0.551
(0.882) 		0.646
(0.936) 		0.187
(0.756) 		0.196
(0.756)
MCTP1 13 (5%) 235 0.238
(0.769) 		0.0153
(0.485) 		0.576
(0.896) 		0.382
(0.826) 		0.647
(0.936) 		0.482
(0.854) 		0.196
(0.756)
ZNF774 10 (4%) 238 0.36
(0.805) 		0.581
(0.897) 		0.741
(0.993) 		1
(1.00) 		0.606
(0.908) 		0.711
(0.981) 		0.134
(0.756)
FAM9A 14 (6%) 234 0.337
(0.802) 		0.836
(1.00) 		0.433
(0.826) 		0.567
(0.895) 		0.842
(1.00) 		0.683
(0.963) 		1
(1.00)
CFP 8 (3%) 240 0.0127
(0.472) 		0.932
(1.00) 		0.435
(0.826) 		1
(1.00) 		0.211
(0.756) 		0.353
(0.802) 		1
(1.00)
PER3 12 (5%) 236 0.273
(0.775) 		0.521
(0.871) 		0.287
(0.775) 		1
(1.00) 		1
(1.00) 		0.56
(0.889) 		1
(1.00)
ZRANB3 8 (3%) 240 0.257
(0.772) 		0.918
(1.00) 		1
(1.00) 		0.454
(0.834) 		1
(1.00) 		0.273
(0.775) 		1
(1.00)
OMA1 10 (4%) 238 0.35
(0.802) 		0.09
(0.756) 		0.334
(0.802) 		0.172
(0.756) 		0.547
(0.882) 		0.274
(0.775) 		0.134
(0.756)
CLDN15 5 (2%) 243 0.55
(0.882) 		0.327
(0.802) 		0.619
(0.92) 		0.661
(0.949) 		0.416
(0.826) 		0.265
(0.775) 		0.113
(0.756)
TTC39C 7 (3%) 241 0.343
(0.802) 		0.344
(0.802) 		0.428
(0.826) 		1
(1.00) 		1
(1.00) 		0.597
(0.907) 		1
(1.00)
TXNRD1 8 (3%) 240 0.296
(0.775) 		0.632
(0.929) 		0.439
(0.827) 		0.718
(0.983) 		0.361
(0.805) 		0.825
(1.00) 		1
(1.00)
MECOM 12 (5%) 236 0.198
(0.756) 		0.0117
(0.46) 		0.286
(0.775) 		1
(1.00) 		1
(1.00) 		0.811
(1.00) 		1
(1.00)
CCDC147 15 (6%) 233 0.2
(0.756) 		0.0312
(0.623) 		0.47
(0.842) 		1
(1.00) 		0.684
(0.963) 		0.28
(0.775) 		0.196
(0.756)
SACS 26 (10%) 222 0.0694
(0.756) 		0.855
(1.00) 		0.12
(0.756) 		1
(1.00) 		0.709
(0.98) 		0.0494
(0.725) 		0.00311
(0.278)
MUTED 7 (3%) 241 0.352
(0.802) 		0.748
(0.993) 		0.427
(0.826) 		1
(1.00) 		1
(1.00) 		0.0962
(0.756) 		1
(1.00)
SLC44A3 6 (2%) 242 0.469
(0.842) 		0.0571
(0.756) 		0.634
(0.929) 		1
(1.00) 		0.62
(0.92) 		0.424
(0.826) 		1
(1.00)
ZNF674 14 (6%) 234 0.162
(0.756) 		0.101
(0.756) 		0.588
(0.897) 		0.567
(0.895) 		0.532
(0.882) 		0.196
(0.756) 		1
(1.00)
CCDC144A 18 (7%) 230 0.516
(0.869) 		0.128
(0.756) 		0.661
(0.949) 		0.614
(0.914) 		0.346
(0.802) 		0.036
(0.653) 		0.255
(0.772)
OR8B8 7 (3%) 241 0.425
(0.826) 		0.0145
(0.481) 		0.429
(0.826) 		0.427
(0.826) 		0.414
(0.826) 		0.288
(0.775) 		0.113
(0.756)
LNX2 14 (6%) 234 0.215
(0.756) 		0.843
(1.00) 		0.171
(0.756) 		0.147
(0.756) 		0.875
(1.00) 		0.184
(0.756) 		0.235
(0.766)
TMEM62 9 (4%) 239 0.343
(0.802) 		0.506
(0.857) 		0.457
(0.834) 		0.723
(0.986) 		0.602
(0.908) 		0.355
(0.802) 		0.155
(0.756)
ATF7IP 17 (7%) 231 0.135
(0.756) 		0.195
(0.756) 		0.0991
(0.756) 		0.431
(0.826) 		0.887
(1.00) 		0.699
(0.975) 		0.255
(0.772)
IL20 7 (3%) 241 0.338
(0.802) 		0.169
(0.756) 		0.426
(0.826) 		0.24
(0.77) 		0.132
(0.756) 		0.0136
(0.481) 		0.0911
(0.756)
C3AR1 8 (3%) 240 0.254
(0.772) 		0.878
(1.00) 		0.438
(0.826) 		1
(1.00) 		0.605
(0.908) 		0.179
(0.756) 		0.134
(0.756)
PKD2 8 (3%) 240 0.37
(0.812) 		0.154
(0.756) 		0.436
(0.826) 		0.268
(0.775) 		0.548
(0.882) 		0.347
(0.802) 		0.134
(0.756)
BMP5 13 (5%) 235 0.174
(0.756) 		0.146
(0.756) 		0.573
(0.896) 		0.551
(0.882) 		0.649
(0.936) 		0.0436
(0.687) 		0.216
(0.756)
OR52I2 8 (3%) 240 0.999
(1.00) 		0.679
(0.963) 		0.157
(0.756) 		0.454
(0.834) 		0.788
(1.00) 		0.35
(0.802) 		1
(1.00)
C1ORF100 9 (4%) 239 0.277
(0.775) 		0.139
(0.756) 		0.454
(0.834) 		0.502
(0.854) 		0.482
(0.854) 		0.352
(0.802) 		0.0911
(0.756)
CCDC160 11 (4%) 237 0.224
(0.766) 		0.204
(0.756) 		0.354
(0.802) 		1
(1.00) 		0.843
(1.00) 		0.401
(0.826) 		1
(1.00)
NAA15 14 (6%) 234 0.587
(0.897) 		0.991
(1.00) 		0.586
(0.897) 		0.252
(0.772) 		0.874
(1.00) 		0.232
(0.766) 		0.196
(0.756)
RNF31 17 (7%) 231 0.218
(0.756) 		0.692
(0.969) 		0.807
(1.00) 		0.602
(0.908) 		0.258
(0.772) 		0.138
(0.756) 		0.216
(0.756)
NFE2L3 12 (5%) 236 0.254
(0.772) 		0.781
(1.00) 		0.216
(0.756) 		0.117
(0.756) 		0.424
(0.826) 		0.206
(0.756) 		1
(1.00)
ZKSCAN1 7 (3%) 241 0.41
(0.826) 		0.968
(1.00) 		1
(1.00) 		0.696
(0.973) 		0.742
(0.993) 		0.599
(0.907) 		1
(1.00)
CDKL1 7 (3%) 241 0.427
(0.826) 		0.0112
(0.46) 		0.427
(0.826) 		1
(1.00) 		0.427
(0.826) 		0.0747
(0.756) 		0.113
(0.756)
ERBB3 17 (7%) 231 0.185
(0.756) 		0.598
(0.907) 		0.491
(0.854) 		0.602
(0.908) 		0.292
(0.775) 		0.0904
(0.756) 		1
(1.00)
SELP 9 (4%) 239 0.983
(1.00) 		0.105
(0.756) 		0.456
(0.834) 		1
(1.00) 		0.212
(0.756) 		0.06
(0.756) 		0.134
(0.756)
PPIG 16 (6%) 232 0.256
(0.772) 		0.0726
(0.756) 		0.119
(0.756) 		0.187
(0.756) 		0.913
(1.00) 		0.931
(1.00) 		0.235
(0.766)
GPRASP1 21 (8%) 227 0.144
(0.756) 		0.17
(0.756) 		0.275
(0.775) 		0.812
(1.00) 		0.643
(0.936) 		0.675
(0.96) 		0.273
(0.775)
REV3L 20 (8%) 228 0.121
(0.756) 		0.503
(0.854) 		0.0683
(0.756) 		0.464
(0.839) 		1
(1.00) 		0.152
(0.756) 		0.273
(0.775)
CTNNA1 13 (5%) 235 0.203
(0.756) 		0.428
(0.826) 		0.573
(0.896) 		0.771
(1.00) 		0.416
(0.826) 		0.0306
(0.623) 		1
(1.00)
MRPL47 6 (2%) 242 0.487
(0.854) 		0.92
(1.00) 		1
(1.00) 		0.421
(0.826) 		0.481
(0.854) 		1
(1.00) 		0.0911
(0.756)
DEPDC1B 11 (4%) 237 0.992
(1.00) 		0.592
(0.902) 		0.745
(0.993) 		0.521
(0.871) 		0.193
(0.756) 		0.049
(0.725) 		1
(1.00)
CASP8 17 (7%) 231 0.561
(0.889) 		0.748
(0.993) 		0.489
(0.854) 		1
(1.00) 		0.545
(0.882) 		0.028
(0.623) 		0.0295
(0.623)
CACNB4 10 (4%) 238 0.353
(0.802) 		0.19
(0.756) 		0.336
(0.802) 		0.501
(0.854) 		0.492
(0.854) 		0.112
(0.756) 		1
(1.00)
BHLHB9 8 (3%) 240 0.388
(0.826) 		0.398
(0.826) 		0.436
(0.826) 		1
(1.00) 		0.743
(0.993) 		0.404
(0.826) 		1
(1.00)
C22ORF25 6 (2%) 242 0.495
(0.854) 		0.984
(1.00) 		0.636
(0.929) 		0.0201
(0.544) 		0.675
(0.96) 		0.0689
(0.756)
GALNT7 11 (4%) 237 0.684
(0.963) 		0.435
(0.826) 		0.744
(0.993) 		0.103
(0.756) 		0.0243
(0.588) 		0.0167
(0.5) 		0.176
(0.756)
LGMN 7 (3%) 241 0.0572
(0.756) 		0.987
(1.00) 		0.427
(0.826) 		0.24
(0.77) 		0.288
(0.775) 		1
(1.00) 		1
(1.00)
EPS8 12 (5%) 236 0.927
(1.00) 		0.124
(0.756) 		0.751
(0.993) 		1
(1.00) 		0.702
(0.975) 		0.403
(0.826) 		0.196
(0.756)
TGOLN2 3 (1%) 245 0.575
(0.896) 		0.0514
(0.736) 		1
(1.00) 		0.553
(0.882) 		1
(1.00) 		1
(1.00) 		1
(1.00)
TPX2 6 (2%) 242 0.567
(0.895) 		0.0114
(0.46) 		0.635
(0.929) 		1
(1.00) 		0.141
(0.756) 		0.672
(0.957) 		0.0689
(0.756)
C14ORF118 15 (6%) 233 0.237
(0.768) 		0.0161
(0.492) 		0.141
(0.756) 		0.587
(0.897) 		0.872
(1.00) 		0.502
(0.854) 		0.196
(0.756)
SLC34A3 6 (2%) 242 0.445
(0.834) 		0.108
(0.756) 		0.633
(0.929) 		0.421
(0.826) 		1
(1.00) 		0.233
(0.766) 		1
(1.00)
ZNF662 13 (5%) 235 0.221
(0.761) 		0.493
(0.854) 		0.574
(0.896) 		0.771
(1.00) 		0.645
(0.936) 		0.278
(0.775) 		0.176
(0.756)
ZDBF2 18 (7%) 230 0.159
(0.756) 		0.186
(0.756) 		0.0856
(0.756) 		0.311
(0.787) 		0.763
(0.999) 		0.725
(0.987) 		0.255
(0.772)
SFRP4 8 (3%) 240 0.317
(0.799) 		0.124
(0.756) 		0.437
(0.826) 		1
(1.00) 		0.428
(0.826) 		0.346
(0.802) 		0.113
(0.756)
CCDC146 14 (6%) 234 0.217
(0.756) 		0.033
(0.633) 		0.173
(0.756) 		0.391
(0.826) 		0.646
(0.936) 		0.229
(0.766) 		0.196
(0.756)
C7ORF60 10 (4%) 238 0.302
(0.779) 		0.172
(0.756) 		0.337
(0.802) 		0.322
(0.802) 		0.605
(0.908) 		1
(1.00) 		0.155
(0.756)
ZNF649 14 (6%) 234 0.233
(0.766) 		0.185
(0.756) 		0.173
(0.756) 		0.776
(1.00) 		0.875
(1.00) 		0.909
(1.00) 		0.196
(0.756)
RASSF9 9 (4%) 239 0.264
(0.775) 		0.0134
(0.481) 		0.458
(0.834) 		0.723
(0.986) 		0.603
(0.908) 		0.167
(0.756) 		0.134
(0.756)
NIPA2 8 (3%) 240 0.35
(0.802) 		0.986
(1.00) 		1
(1.00) 		0.718
(0.983) 		1
(1.00) 		0.0338
(0.638) 		1
(1.00)
FILIP1 16 (6%) 232 0.149
(0.756) 		0.596
(0.906) 		0.48
(0.853) 		0.187
(0.756) 		0.682
(0.963) 		0.802
(1.00) 		0.176
(0.756)
PHKA2 16 (6%) 232 0.152
(0.756) 		0.538
(0.882) 		0.479
(0.853) 		0.792
(1.00) 		0.795
(1.00) 		0.0806
(0.756) 		1
(1.00)
COBLL1 15 (6%) 233 0.207
(0.756) 		0.979
(1.00) 		0.139
(0.756) 		0.587
(0.897) 		0.372
(0.814) 		0.503
(0.854) 		0.216
(0.756)
AGPAT9 8 (3%) 240 0.295
(0.775) 		0.63
(0.929) 		0.435
(0.826) 		0.0535
(0.752) 		0.278
(0.775) 		0.176
(0.756) 		0.134
(0.756)
NOP56 11 (4%) 237 0.248
(0.772) 		0.137
(0.756) 		0.352
(0.802) 		0.752
(0.993) 		0.829
(1.00) 		0.398
(0.826) 		1
(1.00)
RBL2 12 (5%) 236 0.766
(1.00) 		0.211
(0.756) 		0.287
(0.775) 		1
(1.00) 		0.193
(0.756) 		0.152
(0.756) 		0.196
(0.756)
ABCC6 12 (5%) 236 0.476
(0.852) 		0.545
(0.882) 		0.0583
(0.756) 		0.117
(0.756) 		0.287
(0.775) 		0.876
(1.00) 		0.176
(0.756)
CCDC104 10 (4%) 238 0.284
(0.775) 		0.0971
(0.756) 		0.337
(0.802) 		0.501
(0.854) 		1
(1.00) 		0.585
(0.897) 		1
(1.00)
MLL2 33 (13%) 215 0.0883
(0.756) 		0.55
(0.882) 		0.146
(0.756) 		1
(1.00) 		0.867
(1.00) 		0.092
(0.756) 		0.442
(0.829)
SSH2 12 (5%) 236 0.239
(0.769) 		0.208
(0.756) 		0.753
(0.993) 		0.757
(0.993) 		0.686
(0.963) 		0.00772
(0.447) 		0.0174
(0.511)
ZNF709 12 (5%) 236 0.206
(0.756) 		0.246
(0.772) 		0.287
(0.775) 		1
(1.00) 		0.705
(0.978) 		0.15
(0.756) 		0.155
(0.756)
BRDT 14 (6%) 234 0.213
(0.756) 		0.0842
(0.756) 		0.171
(0.756) 		0.391
(0.826) 		0.648
(0.936) 		0.185
(0.756) 		0.196
(0.756)
SH3BGRL 6 (2%) 242 0.391
(0.826) 		0.26
(0.775) 		0.634
(0.929) 		0.668
(0.956) 		1
(1.00) 		0.029
(0.623) 		1
(1.00)
MLH3 17 (7%) 231 0.668
(0.956) 		0.00875
(0.447) 		0.491
(0.854) 		1
(1.00) 		0.257
(0.772) 		0.174
(0.756) 		0.255
(0.772)
CCDC150 12 (5%) 236 0.273
(0.775) 		0.931
(1.00) 		0.756
(0.993) 		1
(1.00) 		0.858
(1.00) 		0.894
(1.00) 		1
(1.00)
NT5C3 7 (3%) 241 0.321
(0.802) 		0.506
(0.857) 		0.425
(0.826) 		0.696
(0.973) 		0.549
(0.882) 		0.128
(0.756) 		0.113
(0.756)
APAF1 13 (5%) 235 0.635
(0.929) 		0.44
(0.827) 		0.301
(0.779) 		0.551
(0.882) 		0.206
(0.756) 		0.158
(0.756) 		0.176
(0.756)
KANK4 11 (4%) 237 0.902
(1.00) 		0.043
(0.687) 		0.744
(0.993) 		0.521
(0.871) 		1
(1.00) 		0.516
(0.869) 		1
(1.00)
NRIP1 13 (5%) 235 0.244
(0.772) 		0.117
(0.756) 		0.576
(0.896) 		1
(1.00) 		0.422
(0.826) 		0.36
(0.805) 		1
(1.00)
GTF2H1 8 (3%) 240 0.351
(0.802) 		0.946
(1.00) 		0.435
(0.826) 		0.718
(0.983) 		0.548
(0.882) 		0.5
(0.854) 		0.134
(0.756)
ASXL2 14 (6%) 234 0.208
(0.756) 		0.381
(0.824) 		0.584
(0.897) 		1
(1.00) 		0.221
(0.761) 		0.524
(0.874) 		0.176
(0.756)
ZNF611 12 (5%) 236 0.913
(1.00) 		0.244
(0.772) 		0.291
(0.775) 		1
(1.00) 		0.205
(0.756) 		0.206
(0.756) 		0.196
(0.756)
SUN3 6 (2%) 242 0.426
(0.826) 		0.0127
(0.472) 		0.633
(0.929) 		1
(1.00) 		0.416
(0.826) 		0.202
(0.756) 		0.00244
(0.259)
ZNF195 11 (4%) 237 0.283
(0.775) 		0.023
(0.566) 		0.355
(0.802) 		0.752
(0.993) 		0.656
(0.943) 		0.119
(0.756) 		0.176
(0.756)
EXOSC9 10 (4%) 238 0.288
(0.775) 		0.78
(1.00) 		0.334
(0.802) 		1
(1.00) 		0.603
(0.908) 		0.412
(0.826) 		0.155
(0.756)
MFN2 9 (4%) 239 0.402
(0.826) 		0.357
(0.804) 		0.454
(0.834) 		0.502
(0.854) 		1
(1.00) 		0.483
(0.854) 		0.134
(0.756)
LIMA1 8 (3%) 240 0.407
(0.826) 		0.888
(1.00) 		0.437
(0.826) 		0.718
(0.983) 		1
(1.00) 		0.662
(0.949) 		1
(1.00)
PTPN12 10 (4%) 238 0.907
(1.00) 		0.829
(1.00) 		0.337
(0.802) 		0.501
(0.854) 		0.606
(0.908) 		0.232
(0.766) 		0.155
(0.756)
MTF2 9 (4%) 239 0.369
(0.812) 		0.0734
(0.756) 		0.456
(0.834) 		1
(1.00) 		1
(1.00) 		0.191
(0.756) 		1
(1.00)
MLL4 30 (12%) 218 0.0597
(0.756) 		0.245
(0.772) 		0.0425
(0.687) 		0.839
(1.00) 		0.651
(0.939) 		0.295
(0.775) 		0.427
(0.826)
C1ORF101 12 (5%) 236 0.258
(0.772) 		0.0191
(0.528) 		0.287
(0.775) 		1
(1.00) 		0.742
(0.993) 		0.149
(0.756) 		0.196
(0.756)
MBOAT2 7 (3%) 241 0.394
(0.826) 		0.0885
(0.756) 		1
(1.00) 		1
(1.00) 		1
(1.00) 		0.291
(0.775) 		1
(1.00)
CHD4 35 (14%) 213 0.428
(0.826) 		0.425
(0.826) 		0.453
(0.834) 		0.45
(0.834) 		1
(1.00) 		0.736
(0.993) 		1
(1.00)
SESN3 13 (5%) 235 0.219
(0.758) 		0.468
(0.842) 		0.304
(0.781) 		0.771
(1.00) 		0.7
(0.975) 		0.896
(1.00) 		0.196
(0.756)
'PTEN MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S1.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PTEN MUTATED 159 1 1
PTEN WILD-TYPE 41 3 43

Figure S1.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'PTEN MUTATION STATUS' versus 'RACE'

P value = 0.00063 (Fisher's exact test), Q value = 0.072

Table S2.  Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

nPatients AMERICAN INDIAN OR ALASKA NATIVE ASIAN BLACK OR AFRICAN AMERICAN NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER WHITE
ALL 3 13 25 7 193
PTEN MUTATED 3 10 7 4 133
PTEN WILD-TYPE 0 3 18 3 60

Figure S2.  Get High-res Image Gene #1: 'PTEN MUTATION STATUS' versus Clinical Feature #6: 'RACE'

'PIK3R1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S3.  Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PIK3R1 MUTATED 80 1 2
PIK3R1 WILD-TYPE 120 3 42

Figure S3.  Get High-res Image Gene #2: 'PIK3R1 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'TP53 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 5.85e-06 (Wilcoxon-test), Q value = 0.0028

Table S4.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
TP53 MUTATED 69 67.9 (9.4)
TP53 WILD-TYPE 179 61.3 (11.2)

Figure S4.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'TP53 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S5.  Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
TP53 MUTATED 27 3 39
TP53 WILD-TYPE 173 1 5

Figure S5.  Get High-res Image Gene #3: 'TP53 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'CTCF MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00017 (Fisher's exact test), Q value = 0.033

Table S6.  Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTCF MUTATED 44 0 0
CTCF WILD-TYPE 156 4 44

Figure S6.  Get High-res Image Gene #4: 'CTCF MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'KRAS MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000544 (Wilcoxon-test), Q value = 0.068

Table S7.  Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
KRAS MUTATED 53 58.8 (8.7)
KRAS WILD-TYPE 195 64.3 (11.4)

Figure S7.  Get High-res Image Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'KRAS MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00022 (Fisher's exact test), Q value = 0.038

Table S8.  Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
KRAS MUTATED 52 0 1
KRAS WILD-TYPE 148 4 43

Figure S8.  Get High-res Image Gene #6: 'KRAS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'ARID1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 9e-05 (Fisher's exact test), Q value = 0.021

Table S9.  Gene #9: 'ARID1A MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
ARID1A MUTATED 78 1 4
ARID1A WILD-TYPE 122 3 40

Figure S9.  Get High-res Image Gene #9: 'ARID1A MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'CTNNB1 MUTATION STATUS' versus 'YEARS_TO_BIRTH'

P value = 0.000515 (Wilcoxon-test), Q value = 0.068

Table S10.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

nPatients Mean (Std.Dev)
ALL 248 63.1 (11.1)
CTNNB1 MUTATED 74 59.6 (11.6)
CTNNB1 WILD-TYPE 174 64.6 (10.6)

Figure S10.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #2: 'YEARS_TO_BIRTH'

'CTNNB1 MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 1e-05 (Fisher's exact test), Q value = 0.0028

Table S11.  Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
CTNNB1 MUTATED 74 0 0
CTNNB1 WILD-TYPE 126 4 44

Figure S11.  Get High-res Image Gene #10: 'CTNNB1 MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

'PPP2R1A MUTATION STATUS' versus 'HISTOLOGICAL_TYPE'

P value = 0.00042 (Fisher's exact test), Q value = 0.064

Table S12.  Gene #43: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 200 4 44
PPP2R1A MUTATED 14 1 12
PPP2R1A WILD-TYPE 186 3 32

Figure S12.  Get High-res Image Gene #43: 'PPP2R1A MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL_TYPE'

Methods & Data
Input

  • Mutation data file = sample_sig_gene_table.txt from Mutsig_2CV pipeline

  • Processed Mutation data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_Correlate_Genomic_Events_Preprocess/UCEC-TP/15165175/transformed.cor.cli.txt

  • Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/UCEC-TP/15094079/UCEC-TP.merged_data.txt

  • Number of patients = 248

  • Number of significantly mutated genes = 197

  • Number of selected clinical features = 7

  • Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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