Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.053 0.173 -9999.0 0.0 -0.593 36.0 36.0 IHH -0.128 0.2 -9999.0 0.0 -0.393 189.0 189.0 SHH Np/Cholesterol/GAS1 -0.146 0.13 -9999.0 0.0 -0.232 358.0 358.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.145 0.129 0.231 358.0 -9999.0 0.0 358.0 SMO/beta Arrestin2 -0.051 0.154 -9999.0 0.0 -0.415 26.0 26.0 SMO -0.059 0.161 -9999.0 0.0 -0.316 137.0 137.0 AKT1 -0.017 0.095 -9999.0 0.0 -0.473 6.0 6.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.075 -9999.0 0.0 -0.41 18.0 18.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 STIL -0.048 0.115 -9999.0 0.0 -0.343 32.0 32.0 DHH N/PTCH2 -0.024 0.106 -9999.0 0.0 -0.295 70.0 70.0 DHH N/PTCH1 -0.059 0.137 -9999.0 0.0 -0.392 38.0 38.0 PIK3CA 0.01 0.018 -9999.0 0.0 -0.41 1.0 1.0 DHH -0.024 0.115 -9999.0 0.0 -0.41 44.0 44.0 PTHLH -0.068 0.21 -9999.0 0.0 -0.648 36.0 36.0 determination of left/right symmetry -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 PIK3R1 0.007 0.04 -9999.0 0.0 -0.41 5.0 5.0 skeletal system development -0.067 0.208 -9999.0 0.0 -0.641 36.0 36.0 IHH N/Hhip -0.079 0.132 -9999.0 0.0 -0.264 157.0 157.0 DHH N/Hhip -0.024 0.099 -9999.0 0.0 -0.264 77.0 77.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 pancreas development -0.012 0.087 -9999.0 0.0 -0.342 35.0 35.0 HHAT 0.008 0.036 -9999.0 0.0 -0.41 4.0 4.0 PI3K 0.013 0.031 -9999.0 0.0 -0.28 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.257 0.203 -9999.0 0.0 -0.41 346.0 346.0 somite specification -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 SHH Np/Cholesterol/PTCH1 -0.051 0.115 -9999.0 0.0 -0.363 25.0 25.0 SHH Np/Cholesterol/PTCH2 -0.017 0.079 -9999.0 0.0 -0.179 99.0 99.0 SHH Np/Cholesterol/Megalin -0.067 0.103 -9999.0 0.0 -0.176 238.0 238.0 SHH -0.015 0.082 -9999.0 0.0 -0.223 73.0 73.0 catabolic process -0.053 0.136 -9999.0 0.0 -0.354 36.0 36.0 SMO/Vitamin D3 -0.048 0.139 -9999.0 0.0 -0.401 26.0 26.0 SHH Np/Cholesterol/Hhip -0.017 0.075 -9999.0 0.0 -0.167 104.0 104.0 LRP2 -0.11 0.162 -9999.0 0.0 -0.329 193.0 193.0 receptor-mediated endocytosis -0.074 0.136 -9999.0 0.0 -0.321 79.0 79.0 SHH Np/Cholesterol/BOC -0.012 0.073 -9999.0 0.0 -0.174 88.0 88.0 SHH Np/Cholesterol/CDO -0.029 0.096 -9999.0 0.0 -0.202 118.0 118.0 mesenchymal cell differentiation 0.017 0.074 0.166 104.0 -9999.0 0.0 104.0 mol:Vitamin D3 -0.04 0.122 -9999.0 0.0 -0.365 25.0 25.0 IHH N/PTCH2 -0.079 0.138 -9999.0 0.0 -0.277 148.0 148.0 CDON -0.035 0.131 -9999.0 0.0 -0.41 59.0 59.0 IHH N/PTCH1 -0.034 0.148 -9999.0 0.0 -0.357 36.0 36.0 Megalin/LRPAP1 -0.067 0.111 -9999.0 0.0 -0.217 193.0 193.0 PTCH2 -0.012 0.096 -9999.0 0.0 -0.41 30.0 30.0 SHH Np/Cholesterol -0.012 0.06 -9999.0 0.0 -0.165 73.0 73.0 PTCH1 -0.053 0.136 -9999.0 0.0 -0.355 36.0 36.0 HHIP -0.012 0.087 -9999.0 0.0 -0.343 35.0 35.0