Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0 epithelial cell differentiation 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.35 3.0 3.0 ENAH -0.006 0.057 0.259 13.0 -9999.0 0.0 13.0 EGFR 0.014 0.059 0.327 1.0 -0.35 13.0 14.0 EPHA2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.012 0.025 0.173 7.0 -9999.0 0.0 7.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.017 -9999.0 0.0 -0.208 1.0 1.0 AQP5 0.077 0.088 0.264 3.0 -0.373 7.0 10.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.019 0.169 3.0 -9999.0 0.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.037 0.17 7.0 -0.181 15.0 22.0 EGF 0.031 0.055 0.279 21.0 -0.35 2.0 23.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.001 0.057 -9999.0 0.0 -0.304 15.0 15.0 cortical microtubule organization 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 GO:0000145 -0.013 0.017 0.158 3.0 -0.163 1.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.024 -9999.0 0.0 -0.17 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.031 -9999.0 0.0 -0.191 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.016 0.164 3.0 -9999.0 0.0 3.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.024 0.171 6.0 -0.173 1.0 7.0 ARF6/GTP 0.047 0.033 -9999.0 0.0 -0.18 2.0 2.0 CDH1 0.019 0.024 -9999.0 0.0 -0.35 2.0 2.0 EGFR/EGFR/EGF/EGF 0.033 0.044 -9999.0 0.0 -0.179 14.0 14.0 RhoA/GDP 0.042 0.023 -9999.0 0.0 -0.163 2.0 2.0 actin cytoskeleton organization -0.014 0.022 0.159 6.0 -0.175 1.0 7.0 IGF-1R heterotetramer 0.009 0.069 -9999.0 0.0 -0.35 19.0 19.0 GIT1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.069 -9999.0 0.0 -0.35 19.0 19.0 IGF1 -0.046 0.145 -9999.0 0.0 -0.35 100.0 100.0 DIAPH1 0.018 0.096 -9999.0 0.0 -0.535 6.0 6.0 Wnt receptor signaling pathway -0.041 0.022 0.168 2.0 -9999.0 0.0 2.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.022 0.16 6.0 -0.178 1.0 7.0 EFNA1 0.02 0.02 0.303 2.0 -9999.0 0.0 2.0 LPP -0.014 0.023 0.166 6.0 -0.168 1.0 7.0 Ephrin A1/EPHA2 0.03 0.025 -9999.0 0.0 -0.162 2.0 2.0 SEC6/SEC8 -0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.016 0.037 0.172 7.0 -0.183 15.0 22.0 HGF/MET -0.003 0.088 -9999.0 0.0 -0.174 102.0 102.0 HGF -0.05 0.147 -9999.0 0.0 -0.35 104.0 104.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.025 -9999.0 0.0 -0.182 8.0 8.0 actin cable formation 0.047 0.105 0.225 107.0 -0.244 2.0 109.0 KIAA1543 -0.013 0.023 0.161 6.0 -0.166 2.0 8.0 KIFC3 -0.013 0.023 0.171 6.0 -0.173 1.0 7.0 NCK1 0.021 0.023 -9999.0 0.0 -0.35 2.0 2.0 EXOC3 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.025 0.173 7.0 -0.173 1.0 8.0 NCK1/GIT1 0.03 0.02 -9999.0 0.0 -0.246 2.0 2.0 mol:GDP 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 EXOC4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.025 0.172 7.0 -9999.0 0.0 7.0 PIP5K1C -0.013 0.019 0.171 3.0 -9999.0 0.0 3.0 LIMA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.086 0.295 19.0 -9999.0 0.0 19.0 adherens junction assembly -0.044 0.14 0.205 1.0 -0.554 31.0 32.0 IGF-1R heterotetramer/IGF1 -0.007 0.092 -9999.0 0.0 -0.184 107.0 107.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.042 0.279 4.0 -0.35 5.0 9.0 PLEKHA7 -0.013 0.025 0.172 6.0 -0.173 2.0 8.0 mol:GTP 0.042 0.03 -9999.0 0.0 -0.19 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.001 0.077 0.338 14.0 -9999.0 0.0 14.0 cortical actin cytoskeleton stabilization 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0 regulation of cell-cell adhesion -0.014 0.022 0.159 6.0 -0.175 1.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.025 -9999.0 0.0 -0.182 8.0 8.0