Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Aurora B signaling	196.0	13138.0	67.0	-0.289	0.368	1000.0	-1000.0	-0.017	-1000.0
Endothelins	130.0	12495.0	96.0	-0.396	0.161	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	122.0	855.0	7.0	-0.0	0.227	1000.0	-1000.0	-0.006	-1000.0
Signaling events regulated by Ret tyrosine kinase	107.0	8836.0	82.0	-0.145	0.038	1000.0	-1000.0	-0.036	-1000.0
Angiopoietin receptor Tie2-mediated signaling	105.0	9290.0	88.0	-0.303	0.112	1000.0	-1000.0	-0.054	-1000.0
p75(NTR)-mediated signaling	100.0	12511.0	125.0	-0.166	0.075	1000.0	-1000.0	-0.045	-1000.0
FOXM1 transcription factor network	91.0	4641.0	51.0	-0.286	0.273	1000.0	-1000.0	-0.076	-1000.0
PDGFR-alpha signaling pathway	87.0	3867.0	44.0	-0.28	0.037	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by the Hedgehog family	85.0	4440.0	52.0	-0.201	0.11	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	82.0	6302.0	76.0	-0.249	0.044	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	81.0	6823.0	84.0	-0.26	0.096	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	74.0	6367.0	85.0	-0.056	0.25	1000.0	-1000.0	-0.012	-1000.0
Reelin signaling pathway	74.0	4147.0	56.0	-0.116	0.045	1000.0	-1000.0	-0.021	-1000.0
Cellular roles of Anthrax toxin	67.0	2628.0	39.0	-0.093	0.053	1000.0	-1000.0	-0.016	-1000.0
S1P3 pathway	64.0	2728.0	42.0	-0.391	0.031	1000.0	-1000.0	-0.024	-1000.0
Nongenotropic Androgen signaling	63.0	3281.0	52.0	-0.235	0.138	1000.0	-1000.0	-0.018	-1000.0
Fc-epsilon receptor I signaling in mast cells	60.0	5872.0	97.0	-0.096	0.024	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	58.0	3491.0	60.0	-0.137	0.219	1000.0	-1000.0	-0.015	-1000.0
Effects of Botulinum toxin	57.0	1506.0	26.0	-0.102	0.114	1000.0	-1000.0	-0.01	-1000.0
Wnt signaling	56.0	398.0	7.0	-0.065	0.037	1000.0	-1000.0	0.002	-1000.0
Signaling mediated by p38-alpha and p38-beta	53.0	2348.0	44.0	-0.079	0.023	1000.0	-1000.0	-0.014	-1000.0
IGF1 pathway	53.0	3041.0	57.0	-0.076	0.035	1000.0	-1000.0	-0.032	-1000.0
Noncanonical Wnt signaling pathway	52.0	1359.0	26.0	-0.122	0.037	1000.0	-1000.0	-0.024	-1000.0
FOXA2 and FOXA3 transcription factor networks	51.0	2369.0	46.0	-0.197	0.191	1000.0	-1000.0	-0.061	-1000.0
TCGA08_p53	51.0	357.0	7.0	-0.033	0.019	1000.0	-1000.0	-0.008	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	51.0	6135.0	120.0	-0.152	0.114	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	50.0	2402.0	48.0	-0.095	0.028	1000.0	-1000.0	-0.022	-1000.0
Glypican 1 network	48.0	2325.0	48.0	-0.169	0.103	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	46.0	555.0	12.0	-0.11	0.0	1000.0	-1000.0	-0.017	-1000.0
TCGA08_retinoblastoma	46.0	369.0	8.0	-0.04	0.13	1000.0	-1000.0	-0.004	-1000.0
Thromboxane A2 receptor signaling	44.0	4687.0	105.0	-0.136	0.048	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	44.0	3043.0	68.0	-0.149	0.074	1000.0	-1000.0	-0.039	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	41.0	1419.0	34.0	-0.017	0.029	1000.0	-1000.0	-0.023	-1000.0
BMP receptor signaling	41.0	3365.0	81.0	-0.231	0.043	1000.0	-1000.0	-0.017	-1000.0
Plasma membrane estrogen receptor signaling	40.0	3478.0	86.0	-0.192	0.08	1000.0	-1000.0	-0.031	-1000.0
Syndecan-1-mediated signaling events	39.0	1333.0	34.0	-0.05	0.157	1000.0	-1000.0	-0.022	-1000.0
amb2 Integrin signaling	39.0	3200.0	82.0	-0.105	0.128	1000.0	-1000.0	-0.018	-1000.0
S1P1 pathway	39.0	1414.0	36.0	-0.152	0.022	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3063.0	78.0	-0.134	0.055	1000.0	-1000.0	-0.041	-1000.0
Ephrin A  reverse signaling	37.0	262.0	7.0	-0.027	0.012	1000.0	-1000.0	-0.011	-1000.0
EPHB forward signaling	37.0	3222.0	85.0	-0.055	0.048	1000.0	-1000.0	-0.043	-1000.0
LPA receptor mediated events	36.0	3692.0	102.0	-0.134	0.128	1000.0	-1000.0	-0.047	-1000.0
Osteopontin-mediated events	35.0	1346.0	38.0	-0.089	0.097	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	35.0	878.0	25.0	-0.065	0.038	1000.0	-1000.0	-0.011	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	34.0	1878.0	54.0	-0.101	0.048	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	34.0	2970.0	85.0	-0.21	0.031	1000.0	-1000.0	-0.032	-1000.0
IL4-mediated signaling events	34.0	3122.0	91.0	-0.303	0.094	1000.0	-1000.0	-0.083	-1000.0
Arf6 signaling events	33.0	2070.0	62.0	-0.063	0.043	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	33.0	561.0	17.0	-0.091	0.023	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Rods	31.0	1638.0	52.0	-0.057	0.113	1000.0	-1000.0	-0.011	-1000.0
Glucocorticoid receptor regulatory network	29.0	3356.0	114.0	-0.15	0.206	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	29.0	1248.0	43.0	-0.164	0.075	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	29.0	920.0	31.0	-0.09	0.042	1000.0	-1000.0	-0.037	-1000.0
EGFR-dependent Endothelin signaling events	29.0	617.0	21.0	-0.082	0.048	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	28.0	1335.0	47.0	-0.05	0.038	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	27.0	468.0	17.0	-0.065	0.036	1000.0	-1000.0	-0.005	-1000.0
Glypican 2 network	27.0	108.0	4.0	0.023	0.043	1000.0	-1000.0	0.018	-1000.0
Syndecan-4-mediated signaling events	27.0	1832.0	67.0	-0.205	0.128	1000.0	-1000.0	-0.027	-1000.0
Coregulation of Androgen receptor activity	26.0	1992.0	76.0	-0.09	0.125	1000.0	-1000.0	-0.02	-1000.0
Presenilin action in Notch and Wnt signaling	26.0	1638.0	61.0	-0.089	0.083	1000.0	-1000.0	-0.031	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	26.0	1379.0	52.0	-0.055	0.047	1000.0	-1000.0	-0.017	-1000.0
TCR signaling in naïve CD8+ T cells	26.0	2496.0	93.0	-0.015	0.053	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	26.0	684.0	26.0	-0.096	0.032	1000.0	-1000.0	-0.008	-1000.0
Insulin Pathway	26.0	1983.0	74.0	-0.096	0.112	1000.0	-1000.0	-0.034	-1000.0
IL12-mediated signaling events	25.0	2184.0	87.0	-0.296	0.061	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Cones	25.0	959.0	38.0	-0.057	0.033	1000.0	-1000.0	-0.015	-1000.0
Syndecan-2-mediated signaling events	25.0	1744.0	69.0	-0.01	0.103	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	25.0	1911.0	76.0	-0.086	0.037	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3092.0	125.0	-0.056	0.044	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	774.0	33.0	-0.122	0.126	1000.0	-1000.0	-0.017	-1000.0
Regulation of Androgen receptor activity	23.0	1643.0	70.0	-0.038	0.19	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by STAT5	22.0	500.0	22.0	-0.095	0.077	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	21.0	1207.0	57.0	-0.045	0.131	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	21.0	1100.0	51.0	-0.046	0.083	1000.0	-1000.0	-0.032	-1000.0
BCR signaling pathway	21.0	2165.0	99.0	-0.035	0.058	1000.0	-1000.0	-0.051	-1000.0
EPO signaling pathway	20.0	1144.0	55.0	-0.04	0.038	1000.0	-1000.0	-0.024	-1000.0
Regulation of p38-alpha and p38-beta	20.0	1094.0	54.0	-0.135	0.054	1000.0	-1000.0	-0.043	-1000.0
IL6-mediated signaling events	20.0	1521.0	75.0	-0.088	0.09	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	19.0	1281.0	65.0	-0.096	0.052	1000.0	-1000.0	-0.031	-1000.0
mTOR signaling pathway	19.0	1012.0	53.0	-0.029	0.025	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	19.0	1335.0	68.0	-0.082	0.206	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	18.0	1248.0	68.0	-0.181	0.074	1000.0	-1000.0	-0.033	-1000.0
Rapid glucocorticoid signaling	18.0	365.0	20.0	-0.031	0.026	1000.0	-1000.0	-0.009	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2338.0	136.0	-0.088	0.138	1000.0	-1000.0	-0.027	-1000.0
Nectin adhesion pathway	17.0	1100.0	63.0	-0.04	0.054	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	17.0	1035.0	58.0	-0.018	0.05	1000.0	-1000.0	-0.022	-1000.0
ErbB2/ErbB3 signaling events	16.0	1046.0	65.0	-0.076	0.048	1000.0	-1000.0	-0.045	-1000.0
Insulin-mediated glucose transport	16.0	524.0	32.0	-0.085	0.206	1000.0	-1000.0	-0.015	-1000.0
Syndecan-3-mediated signaling events	16.0	585.0	35.0	-0.06	0.095	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	16.0	939.0	58.0	-0.03	0.116	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	15.0	1176.0	76.0	-0.046	0.061	1000.0	-1000.0	-0.022	-1000.0
FoxO family signaling	15.0	990.0	64.0	-0.016	0.206	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	15.0	683.0	45.0	-0.006	0.058	1000.0	-1000.0	-0.029	-1000.0
Regulation of Telomerase	15.0	1628.0	102.0	-0.241	0.087	1000.0	-1000.0	-0.027	-1000.0
IL1-mediated signaling events	14.0	897.0	62.0	-0.014	0.067	1000.0	-1000.0	-0.019	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	14.0	1185.0	83.0	-0.023	0.206	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	14.0	1427.0	97.0	-0.021	0.05	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PRL	14.0	491.0	34.0	-0.036	0.091	1000.0	-1000.0	-0.027	-1000.0
Caspase cascade in apoptosis	13.0	980.0	74.0	-0.027	0.149	1000.0	-1000.0	-0.03	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	365.0	28.0	-0.065	0.041	1000.0	-1000.0	-0.012	-1000.0
JNK signaling in the CD4+ TCR pathway	13.0	235.0	17.0	-0.044	0.056	1000.0	-1000.0	-0.023	-1000.0
ceramide signaling pathway	13.0	648.0	49.0	-0.008	0.054	1000.0	-1000.0	-0.016	-1000.0
IL23-mediated signaling events	13.0	823.0	60.0	-0.007	0.232	1000.0	-1000.0	-0.07	-1000.0
E-cadherin signaling in keratinocytes	13.0	583.0	43.0	-0.009	0.038	1000.0	-1000.0	-0.015	-1000.0
ErbB4 signaling events	12.0	885.0	69.0	-0.05	0.054	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	12.0	930.0	74.0	-0.05	0.077	1000.0	-1000.0	-0.059	-1000.0
IL27-mediated signaling events	11.0	567.0	51.0	-0.033	0.038	1000.0	-1000.0	-0.025	-1000.0
E-cadherin signaling in the nascent adherens junction	11.0	865.0	76.0	-0.029	0.056	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	10.0	394.0	39.0	-0.008	0.053	1000.0	-1000.0	-0.019	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.017	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	334.0	37.0	-0.021	0.063	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	9.0	396.0	40.0	-0.054	0.04	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class II	7.0	577.0	75.0	-0.031	0.045	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events	7.0	512.0	73.0	-0.023	0.042	1000.0	-1000.0	-0.024	-1000.0
Arf6 trafficking events	7.0	542.0	71.0	-0.157	0.04	1000.0	-1000.0	-0.028	-1000.0
p38 MAPK signaling pathway	7.0	347.0	44.0	-0.002	0.063	1000.0	-1000.0	-0.016	-1000.0
TRAIL signaling pathway	5.0	243.0	48.0	-0.01	0.05	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.011	0.025	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class I	4.0	519.0	104.0	-0.035	0.057	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	67.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.02	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	176.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	77.0	23.0	0.002	0.046	1000.0	-1000.0	-0.016	-1000.0
Arf6 downstream pathway	3.0	146.0	43.0	-0.037	0.041	1000.0	-1000.0	-0.024	-1000.0
VEGFR1 specific signals	3.0	182.0	56.0	-0.04	0.047	1000.0	-1000.0	-0.028	-1000.0
Arf1 pathway	3.0	210.0	54.0	-0.005	0.041	1000.0	-1000.0	-0.009	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	10.0	5.0	0.022	0.034	1000.0	-1000.0	0.017	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	64.0	27.0	-0.014	0.054	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	1.0	57.0	31.0	-0.011	0.027	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.019	0.038	1000.0	-1000.0	0.016	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.006	0.048	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Total	4254	255697	7203	-11.7082680564	10.3455851889	131000	-131000	-3.32434031529	-131000