Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within FOXA2 and FOXA3 transcription factor networks 13.0 607.0 46.0 -0.676 0.03 1000.0 -1000.0 -0.103 -1000.0 Signaling events regulated by Ret tyrosine kinase 10.0 867.0 82.0 -0.204 0.012 1000.0 -1000.0 -0.066 -1000.0 IL23-mediated signaling events 9.0 548.0 60.0 -0.433 0.012 1000.0 -1000.0 -0.143 -1000.0 Signaling events mediated by the Hedgehog family 8.0 425.0 52.0 -0.174 0.099 1000.0 -1000.0 -0.035 -1000.0 IL4-mediated signaling events 8.0 772.0 91.0 -0.744 0.615 1000.0 -1000.0 -0.159 -1000.0 TCGA08_retinoblastoma 7.0 61.0 8.0 -0.026 0.02 1000.0 -1000.0 -0.015 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 6.0 234.0 34.0 -0.129 0.012 1000.0 -1000.0 -0.029 -1000.0 TCR signaling in naïve CD8+ T cells 6.0 608.0 93.0 -0.15 0.091 1000.0 -1000.0 -0.067 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 6.0 453.0 68.0 -0.266 0.161 1000.0 -1000.0 -0.093 -1000.0 IL12-mediated signaling events 5.0 479.0 87.0 -0.198 0.013 1000.0 -1000.0 -0.124 -1000.0 Syndecan-1-mediated signaling events 5.0 184.0 34.0 -0.191 0.012 1000.0 -1000.0 -0.047 -1000.0 Ephrin A reverse signaling 5.0 41.0 7.0 -0.058 0.003 1000.0 -1000.0 -0.019 -1000.0 HIF-1-alpha transcription factor network 5.0 445.0 76.0 -0.253 0.026 1000.0 -1000.0 -0.14 -1000.0 p75(NTR)-mediated signaling 5.0 703.0 125.0 -0.208 0.032 1000.0 -1000.0 -0.081 -1000.0 Endothelins 5.0 508.0 96.0 -0.135 0.012 1000.0 -1000.0 -0.072 -1000.0 Signaling mediated by p38-alpha and p38-beta 5.0 225.0 44.0 -0.096 0.012 1000.0 -1000.0 -0.03 -1000.0 Effects of Botulinum toxin 5.0 143.0 26.0 -0.226 0.016 1000.0 -1000.0 -0.05 -1000.0 E-cadherin signaling events 5.0 28.0 5.0 -0.067 0.012 1000.0 -1000.0 -0.022 -1000.0 LPA4-mediated signaling events 4.0 48.0 12.0 -0.09 0.016 1000.0 -1000.0 -0.023 -1000.0 BMP receptor signaling 4.0 329.0 81.0 -0.158 0.05 1000.0 -1000.0 -0.077 -1000.0 Glypican 1 network 4.0 227.0 48.0 -0.185 0.028 1000.0 -1000.0 -0.029 -1000.0 PDGFR-alpha signaling pathway 4.0 193.0 44.0 -0.222 0.019 1000.0 -1000.0 -0.049 -1000.0 amb2 Integrin signaling 4.0 385.0 82.0 -0.159 0.017 1000.0 -1000.0 -0.064 -1000.0 Glucocorticoid receptor regulatory network 4.0 558.0 114.0 -0.416 0.275 1000.0 -1000.0 -0.053 -1000.0 Reelin signaling pathway 4.0 247.0 56.0 -0.125 0.032 1000.0 -1000.0 -0.064 -1000.0 Integrins in angiogenesis 4.0 349.0 84.0 -0.108 0.022 1000.0 -1000.0 -0.072 -1000.0 Wnt signaling 4.0 33.0 7.0 -0.065 -0.005 1000.0 -1000.0 -0.018 -1000.0 Syndecan-4-mediated signaling events 4.0 289.0 67.0 -0.121 0.018 1000.0 -1000.0 -0.056 -1000.0 Plasma membrane estrogen receptor signaling 4.0 376.0 86.0 -0.107 0.07 1000.0 -1000.0 -0.067 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 4.0 550.0 120.0 -0.16 0.114 1000.0 -1000.0 -0.057 -1000.0 Caspase cascade in apoptosis 3.0 283.0 74.0 -0.123 0.031 1000.0 -1000.0 -0.034 -1000.0 Regulation of nuclear SMAD2/3 signaling 3.0 465.0 136.0 -0.244 0.177 1000.0 -1000.0 -0.047 -1000.0 Coregulation of Androgen receptor activity 3.0 249.0 76.0 -0.258 0.027 1000.0 -1000.0 -0.027 -1000.0 Visual signal transduction: Cones 3.0 136.0 38.0 -0.066 0.012 1000.0 -1000.0 -0.024 -1000.0 Noncanonical Wnt signaling pathway 3.0 85.0 26.0 -0.079 0.012 1000.0 -1000.0 -0.037 -1000.0 Arf6 signaling events 3.0 198.0 62.0 -0.132 0.031 1000.0 -1000.0 -0.038 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 3.0 266.0 85.0 -0.132 0.012 1000.0 -1000.0 -0.065 -1000.0 Signaling events mediated by HDAC Class III 3.0 125.0 40.0 -0.152 0.121 1000.0 -1000.0 -0.025 -1000.0 TRAIL signaling pathway 3.0 189.0 48.0 -0.061 0.012 1000.0 -1000.0 -0.054 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 3.0 192.0 52.0 -0.177 0.036 1000.0 -1000.0 -0.042 -1000.0 Retinoic acid receptors-mediated signaling 3.0 198.0 58.0 -0.166 0.025 1000.0 -1000.0 -0.064 -1000.0 Canonical Wnt signaling pathway 3.0 166.0 51.0 -0.158 0.071 1000.0 -1000.0 -0.057 -1000.0 Nongenotropic Androgen signaling 3.0 158.0 52.0 -0.073 0.012 1000.0 -1000.0 -0.039 -1000.0 IL6-mediated signaling events 3.0 293.0 75.0 -0.161 0.042 1000.0 -1000.0 -0.066 -1000.0 IL2 signaling events mediated by STAT5 3.0 74.0 22.0 -0.129 0.013 1000.0 -1000.0 -0.043 -1000.0 IGF1 pathway 3.0 202.0 57.0 -0.086 0.025 1000.0 -1000.0 -0.074 -1000.0 Angiopoietin receptor Tie2-mediated signaling 3.0 343.0 88.0 -0.125 0.018 1000.0 -1000.0 -0.083 -1000.0 Visual signal transduction: Rods 3.0 196.0 52.0 -0.101 0.015 1000.0 -1000.0 -0.062 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 3.0 282.0 78.0 -0.075 0.042 1000.0 -1000.0 -0.066 -1000.0 ErbB2/ErbB3 signaling events 2.0 183.0 65.0 -0.199 0.018 1000.0 -1000.0 -0.053 -1000.0 ErbB4 signaling events 2.0 183.0 69.0 -0.194 0.088 1000.0 -1000.0 -0.083 -1000.0 BARD1 signaling events 2.0 119.0 57.0 -0.058 0.036 1000.0 -1000.0 -0.051 -1000.0 Osteopontin-mediated events 2.0 85.0 38.0 -0.06 0.02 1000.0 -1000.0 -0.079 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 2.0 147.0 54.0 -0.125 0.023 1000.0 -1000.0 -0.073 -1000.0 JNK signaling in the CD4+ TCR pathway 2.0 44.0 17.0 -0.047 0.012 1000.0 -1000.0 -0.035 -1000.0 Thromboxane A2 receptor signaling 2.0 240.0 105.0 -0.092 0.025 1000.0 -1000.0 -0.057 -1000.0 Syndecan-2-mediated signaling events 2.0 171.0 69.0 -0.08 0.029 1000.0 -1000.0 -0.03 -1000.0 Cellular roles of Anthrax toxin 2.0 105.0 39.0 -0.091 0.012 1000.0 -1000.0 -0.02 -1000.0 Signaling events mediated by PTP1B 2.0 221.0 76.0 -0.199 0.02 1000.0 -1000.0 -0.06 -1000.0 Presenilin action in Notch and Wnt signaling 2.0 169.0 61.0 -0.158 0.032 1000.0 -1000.0 -0.061 -1000.0 Nectin adhesion pathway 2.0 175.0 63.0 -0.067 0.024 1000.0 -1000.0 -0.064 -1000.0 FAS signaling pathway (CD95) 2.0 115.0 47.0 -0.132 0.019 1000.0 -1000.0 -0.033 -1000.0 Syndecan-3-mediated signaling events 2.0 99.0 35.0 -0.134 0.032 1000.0 -1000.0 -0.035 -1000.0 IL2 signaling events mediated by PI3K 2.0 119.0 58.0 -0.063 0.027 1000.0 -1000.0 -0.077 -1000.0 Calcium signaling in the CD4+ TCR pathway 2.0 87.0 31.0 -0.112 0.012 1000.0 -1000.0 -0.048 -1000.0 IL27-mediated signaling events 2.0 128.0 51.0 -0.118 0.034 1000.0 -1000.0 -0.066 -1000.0 LPA receptor mediated events 2.0 286.0 102.0 -0.079 0.023 1000.0 -1000.0 -0.069 -1000.0 E-cadherin signaling in the nascent adherens junction 2.0 178.0 76.0 -0.067 0.024 1000.0 -1000.0 -0.072 -1000.0 BCR signaling pathway 2.0 286.0 99.0 -0.155 0.013 1000.0 -1000.0 -0.072 -1000.0 EGFR-dependent Endothelin signaling events 2.0 43.0 21.0 -0.031 0.018 1000.0 -1000.0 -0.048 -1000.0 Rapid glucocorticoid signaling 2.0 42.0 20.0 -0.047 0.012 1000.0 -1000.0 -0.015 -1000.0 Class IB PI3K non-lipid kinase events 2.0 6.0 3.0 -0.005 -1000.0 1000.0 -1000.0 -0.011 -1000.0 Regulation of Androgen receptor activity 2.0 156.0 70.0 -0.294 0.025 1000.0 -1000.0 -0.046 -1000.0 Signaling events mediated by HDAC Class II 1.0 87.0 75.0 -0.107 0.029 1000.0 -1000.0 -0.035 -1000.0 Sphingosine 1-phosphate (S1P) pathway 1.0 34.0 28.0 -0.048 0.031 1000.0 -1000.0 -0.027 -1000.0 PLK2 and PLK4 events 1.0 4.0 3.0 -0.005 0.012 1000.0 -1000.0 -0.014 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 7.0 5.0 -0.005 0.012 1000.0 -1000.0 -0.018 -1000.0 Hedgehog signaling events mediated by Gli proteins 1.0 72.0 65.0 -0.234 0.045 1000.0 -1000.0 -0.058 -1000.0 Fc-epsilon receptor I signaling in mast cells 1.0 124.0 97.0 -0.062 0.024 1000.0 -1000.0 -0.069 -1000.0 Insulin-mediated glucose transport 1.0 40.0 32.0 -0.108 0.025 1000.0 -1000.0 -0.04 -1000.0 Ceramide signaling pathway 1.0 109.0 76.0 -0.091 0.019 1000.0 -1000.0 -0.035 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 52.0 37.0 -0.055 0.027 1000.0 -1000.0 -0.035 -1000.0 IL1-mediated signaling events 1.0 90.0 62.0 -0.056 0.049 1000.0 -1000.0 -0.071 -1000.0 S1P5 pathway 1.0 29.0 17.0 -0.048 0.013 1000.0 -1000.0 -0.028 -1000.0 Ephrin B reverse signaling 1.0 73.0 48.0 -0.064 0.017 1000.0 -1000.0 -0.052 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 121.0 83.0 -0.133 0.055 1000.0 -1000.0 -0.064 -1000.0 S1P1 pathway 1.0 68.0 36.0 -0.071 0.012 1000.0 -1000.0 -0.043 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 1.0 69.0 45.0 -0.091 0.024 1000.0 -1000.0 -0.074 -1000.0 EPHB forward signaling 1.0 145.0 85.0 -0.109 0.038 1000.0 -1000.0 -0.074 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 1.0 190.0 125.0 -0.064 0.042 1000.0 -1000.0 -0.077 -1000.0 TCGA08_rtk_signaling 1.0 45.0 26.0 -0.046 0.013 1000.0 -1000.0 -0.017 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 1.0 105.0 74.0 -0.132 0.035 1000.0 -1000.0 -0.075 -1000.0 Class I PI3K signaling events 1.0 100.0 73.0 -0.047 0.028 1000.0 -1000.0 -0.042 -1000.0 Regulation of Telomerase 1.0 121.0 102.0 -0.107 0.039 1000.0 -1000.0 -0.088 -1000.0 S1P3 pathway 1.0 49.0 42.0 -0.049 0.023 1000.0 -1000.0 -0.027 -1000.0 PDGFR-beta signaling pathway 1.0 110.0 97.0 -0.109 0.038 1000.0 -1000.0 -0.064 -1000.0 E-cadherin signaling in keratinocytes 1.0 74.0 43.0 -0.067 0.013 1000.0 -1000.0 -0.041 -1000.0 FOXM1 transcription factor network 1.0 53.0 51.0 -0.079 0.106 1000.0 -1000.0 -0.171 -1000.0 S1P4 pathway 1.0 40.0 25.0 -0.048 0.018 1000.0 -1000.0 -0.03 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 31.0 17.0 -0.047 0.015 1000.0 -1000.0 -0.035 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 10.0 23.0 -0.032 0.039 1000.0 -1000.0 -0.048 -1000.0 Canonical NF-kappaB pathway 0.0 29.0 39.0 -0.091 0.067 1000.0 -1000.0 -0.069 -1000.0 Circadian rhythm pathway 0.0 2.0 22.0 -0.012 0.043 1000.0 -1000.0 -0.043 -1000.0 Aurora A signaling 0.0 30.0 60.0 -0.066 0.033 1000.0 -1000.0 -0.028 -1000.0 Arf6 downstream pathway 0.0 11.0 43.0 -0.026 0.027 1000.0 -1000.0 -0.029 -1000.0 Aurora C signaling 0.0 2.0 7.0 -0.001 0.019 1000.0 -1000.0 -0.024 -1000.0 EPO signaling pathway 0.0 49.0 55.0 -0.024 0.036 1000.0 -1000.0 -0.077 -1000.0 PLK1 signaling events 0.0 7.0 85.0 -0.01 0.033 1000.0 -1000.0 -0.034 -1000.0 mTOR signaling pathway 0.0 19.0 53.0 -0.007 0.024 1000.0 -1000.0 -0.049 -1000.0 IFN-gamma pathway 0.0 49.0 68.0 -0.122 0.048 1000.0 -1000.0 -0.075 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 32.0 68.0 -0.108 0.043 1000.0 -1000.0 -0.032 -1000.0 ceramide signaling pathway 0.0 42.0 49.0 -0.09 0.018 1000.0 -1000.0 -0.042 -1000.0 HIF-2-alpha transcription factor network 0.0 26.0 43.0 -0.085 0.087 1000.0 -1000.0 -0.071 -1000.0 Signaling events mediated by HDAC Class I 0.0 97.0 104.0 -0.091 0.048 1000.0 -1000.0 -0.049 -1000.0 TCGA08_p53 0.0 4.0 7.0 -0.005 0.012 1000.0 -1000.0 -0.007 -1000.0 FoxO family signaling 0.0 37.0 64.0 -0.108 0.095 1000.0 -1000.0 -0.068 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 9.0 15.0 0.0 0.024 1000.0 -1000.0 -0.022 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 18.0 36.0 -0.031 0.031 1000.0 -1000.0 -0.057 -1000.0 Atypical NF-kappaB pathway 0.0 28.0 31.0 -0.039 0.023 1000.0 -1000.0 -0.037 -1000.0 Regulation of p38-alpha and p38-beta 0.0 48.0 54.0 -0.082 0.037 1000.0 -1000.0 -0.047 -1000.0 Glypican 2 network 0.0 3.0 4.0 0.003 0.012 1000.0 -1000.0 -0.017 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 1.0 27.0 0.0 0.028 1000.0 -1000.0 -0.042 -1000.0 Arf6 trafficking events 0.0 28.0 71.0 -0.042 0.037 1000.0 -1000.0 -0.066 -1000.0 Insulin Pathway 0.0 26.0 74.0 -0.04 0.036 1000.0 -1000.0 -0.065 -1000.0 VEGFR1 specific signals 0.0 11.0 56.0 -0.005 0.045 1000.0 -1000.0 -0.046 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 24.0 33.0 -0.075 0.036 1000.0 -1000.0 -0.03 -1000.0 Signaling events mediated by PRL 0.0 31.0 34.0 -0.099 0.026 1000.0 -1000.0 -0.031 -1000.0 p38 MAPK signaling pathway 0.0 29.0 44.0 -0.022 0.025 1000.0 -1000.0 -0.056 -1000.0 Arf1 pathway 0.0 2.0 54.0 -0.0 0.026 1000.0 -1000.0 -0.024 -1000.0 Alternative NF-kappaB pathway 0.0 4.0 13.0 0.0 0.032 1000.0 -1000.0 -0.022 -1000.0 Aurora B signaling 0.0 22.0 67.0 -0.097 0.031 1000.0 -1000.0 -0.044 -1000.0 Total 298 21174 7203 -14.7394309732 -994.921700391 131000 -131000 -6.88484974817 -131000